Clostridium butyricum (DSM 10702, ATCC 19398, IAM 14194)

Name: Clostridium butyricum (DSM 10702, ATCC 19398, IAM 14194)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 2563

Type strain

Strain Designation Rowett

Culture col. no. DSM 10702 ATCC 19398 IAM 14194 IFO 13949 JCM 1391 16 more

NCBI tax ID(s) 1316931 1492

Special Collections DSMZ CCUG JCM KCTC CIP Pig DSMZ

History <- ATCC; ATCC 19398 <- NCTC; NCTC 7423 <- J.W. Howie; Rowett ATCC 19398 <-- NCTC 7423 <-- J. W. Howie strain Rowett.

Links

Clostridium butyricum Rowett is an anaerobe bacterium that was isolated from intestine of pig.

anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 92601

LMG 5588,ATCC 19398,CCUG 4217,CECT 361,DSM 552,IFO 13949,JCM 1391,LMG 1217,NCDO 1713,NCIB 7423,NCTC 7423,NCIMB 7423,CIP 103309,VKM B-1773,IAM 14194,KCTC 1786,KCTC 1871,ATCC 16398,LMD 89.156,CCRC 11665,HAMBI 482,NCFB 1713,VTT E-91426,NBRC 13949,NCCB 89156,BCRC 11665,NCAIM B.02000,VTT E-97426,VTT E-991415,CIP 109397,VTT E-911415,DSM 10702

@ref 20215

Last LPSN update 2026-02-09 11:18:18

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Clostridiaceae

Genus Clostridium

Species Clostridium butyricum

Full scientific name Clostridium butyricum Prazmowski 1880 (Approved Lists 1980)

BacDive ID	Other strains from **Clostridium butyricum** (8)	Type strain
2560	C. butyricum 4P1, DSM 2477
2561	C. butyricum DSM 2478, MMP 3
2562	C. butyricum DP1, DSM 6566
23852	C. butyricum AKR102a, DSM 25047
147908	C. butyricum CCUG 34471
152779	C. butyricum CCUG 47601
165627	C. butyricum JCM 7834, IAM 19001
169215	C. butyricum Cla-TS-114, S114, M9-Schm-H4-B, DSM 107392

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
4045	CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)	Medium recipe at MediaDive	Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water
33296	MEDIUM 20 - for Anaerobic bacteria		Agar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)
4045	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)	Medium recipe at MediaDive	Name: PYG MEDIUM (MODIFIED) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
4045	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base

Culture temp

@ref	Growth	Type	Temperature (°C)
4045	positive	growth	37
33296	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
4045	anaerobe
125439	facultative anaerobe	99.8

Spore formation

@ref	Spore formation	Confidence
125439		92.8

Metabolite production

@ref	Metabolite	Production
67770	butyricin 7423

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Suidae (Pig,Swine)
#Host Body-Site	#Gastrointestinal tract	-

Isolation

@ref	Sample type
4045	intestine of pig
67770	Intestine of swine

Taxonmaps

69479

Global distribution of 16S sequence AB595129 (>99% sequence identity) for Clostridium butyricum subclade from Microbeatlas

Aquatic Samples	19472
Soil Samples	17569
Animal Samples	103476
Plant Samples	3000
Total Samples	143517

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
4045	2	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1413179v1 assembly for Clostridium butyricum DSM 10702	complete	GCA_014131795	1492.204	8007355725	1492	96.54
66792	ASM674206v1 assembly for Clostridium butyricum NBRC 13949	complete	GCA_006742065	1492.171	8113800840	1492	96.54
66792	ASM799289v1 assembly for Clostridium butyricum NBRC 13949	contig	GCA_007992895	1492.174	8119575012	1492	58.08
67770	Clostridium butyricum DSM 10702 Genome sequencing assembly for Clostridium butyricum DSM 10702	contig	GCA_000409755	1316931.3	2554235109	1316931	35.98

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Clostridium butyricum gene for 16S rRNA, partial sequence, strain: ATCC 19398	AB075768	1451	1492
20218	Clostridium butyricum gene for 16S ribosomal RNA, partial sequence, strain: JCM 1391	AB595129	1474	1492
20218	Clostridium butyricum strain ATCC19398 16S ribosomal RNA gene, partial sequence	AF396963	371	1492
20218	Clostridium butyricum 16S ribosomal RNA	M59085	1516	1492
4045	Clostridium butyricum partial 16S rRNA gene, strain VPI3266	AJ458420	1425	1492
124043	Clostridium butyricum strain VTT E-97426 16S ribosomal RNA gene, partial sequence.	KU321268	1436	1492

GC content

@ref	GC-content (mol%)	Method
4045	28	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Clostridium butyricum NBRC 13949
NCBI: GCA_006742065

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	92.80	no
125439	motility	BacteriaNetⓘ	yes	88.60	no
125439	gram_stain	BacteriaNetⓘ	positive	86.60	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	99.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Clostridium butyricum DSM 10702
NCBI: GCA_014131795.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	58.56	no
125438	anaerobic	anaerobicⓘ	yes	86.88	yes
125438	aerobic	aerobicⓘ	no	95.59	yes
125438	spore-forming	spore-formingⓘ	yes	75.48	no
125438	thermophilic	thermophileⓘ	no	95.57	yes
125438	flagellated	motile2+ⓘ	yes	75.96	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Harnessing native-cryptic plasmids for stable overexpression of heterologous genes in Clostridium butyricum DSM 10702 for industrial and medical applications.	Zhang Y, Cong Y, Bailey TS, Dubois LJ, Theys J, Lambin P.	Microbiol Res	10.1016/j.micres.2024.127889	2024
Genetics	Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters	Anderson O, Chong J, Thomas G.	Microb Genom		2025
	Clostridium butyricum Bacteremia Associated with Probiotic Use, Japan.	Sada RM, Matsuo H, Motooka D, Kutsuna S, Hamaguchi S, Yamamoto G, Ueda A.	Emerg Infect Dis	10.3201/eid3004.231633	2024
	Flavonoid-converting capabilities of Clostridium butyricum.	Braune A.	Appl Microbiol Biotechnol	10.1007/s00253-025-13434-0	2025
	In vitro investigations on interference of selected probiotic candidates with Campylobacter jejuni adhesion and invasion of primary chicken derived cecal and Caco-2 cells.	Willer T, Han Z, Pielsticker C, Rautenschlein S.	Gut Pathog	10.1186/s13099-024-00623-x	2024
	Biological Routes for Biohydrogen Production: A Clean and Carbon-Free Fuel.	Cha M, Park MS, Kim SJ.	Biotechnol J	10.1002/biot.70074	2025
	Nonsterile Process for Biohydrogen Production: Recent Updates, Challenges, and Opportunities.	Patel SKS, Gupta RK, Karuppanan KK, Padhi DK, Ranganathan S, Paramanantham P, Lee JK.	Indian J Microbiol	10.1007/s12088-024-01319-1	2024
Genetics	Profiling of the intestinal community of Clostridia: taxonomy and evolutionary analysis.	Candeliere F, Musmeci E, Amaretti A, Sola L, Raimondi S, Rossi M.	Microbiome Res Rep	10.20517/mrr.2022.19	2023
	Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia	Sayavedra L, Yasir M, Goldson A, Brion A, Le Gall G, Moreno-Gonzalez M, Altera A, Paxhia M, Warren M, Savva G, Turner A, Beraza N, Narbad A.	Nat Commun		2025
	A universal and wide-range cytosine base editor via domain-inlaid and fidelity-optimized CRISPR-FrCas9.	Hu L, Han J, Wang HD, Cheng ZH, Lv CC, Liu DF, Yu HQ.	Nat Commun	10.1038/s41467-025-56655-7	2025
	Clades, classifications, and claims: evolution of organisms and their nomenclature in life science patents.	Jacobs NT.	J Law Biosci	10.1093/jlb/lsaf026	2025
	Leuconostoc lactis strain APC 3969 produces a new variant of cyclic bacteriocin leucocyclicin Q and displays potent anti-Clostridium perfringens activity.	de Farias FM, Soria MC, O'Connor PM, Huang X, Buttimer C, Kamilari E, Deliephan A, Hill D, Fursenko O, Wiese J, Draper L, Stanton C, Hill C, Ross RP.	Sci Rep	10.1038/s41598-025-89450-x	2025
	Gut microbiota composition before infection determines the Salmonella super- and low-shedder phenotypes in chicken.	Kempf F, Menanteau P, Rychlik I, Kubasova T, Trotereau J, Virlogeux-Payant I, Schaeffer S, Schouler C, Drumo R, Guitton E, Velge P.	Microb Biotechnol	10.1111/1751-7915.13621	2020
	Refined control of CRISPR-Cas9 gene editing in Clostridium sporogenes: the creation of recombinant strains for therapeutic applications.	Kubiak AM, Claessen L, Zhang Y, Khazaie K, Bailey TS.	Front Immunol	10.3389/fimmu.2023.1241632	2023
Metabolism	Clostridium butyricum maximizes growth while minimizing enzyme usage and ATP production: metabolic flux distribution of a strain cultured in glycerol.	Serrano-Bermudez LM, Gonzalez Barrios AF, Maranas CD, Montoya D.	BMC Syst Biol	10.1186/s12918-017-0434-0	2017
Enzymology	Structural diversity and substrate preferences of three tannase enzymes encoded by the anaerobic bacterium Clostridium butyricum.	Ristinmaa AS, Coleman T, Cesar L, Langborg Weinmann A, Mazurkewich S, Branden G, Hasani M, Larsbrink J.	J Biol Chem	10.1016/j.jbc.2022.101758	2022
Metabolism	Fermentative hydrogen production using pretreated microalgal biomass as feedstock.	Wang J, Yin Y.	Microb Cell Fact	10.1186/s12934-018-0871-5	2018
Pathogenicity	Orally administered Odoribacter laneus improves glucose control and inflammatory profile in obese mice by depleting circulating succinate.	Huber-Ruano I, Calvo E, Mayneris-Perxachs J, Rodriguez-Pena MM, Ceperuelo-Mallafre V, Cedo L, Nunez-Roa C, Miro-Blanch J, Arnoriaga-Rodriguez M, Balvay A, Maudet C, Garcia-Roves P, Yanes O, Rabot S, Grimaud GM, De Prisco A, Amoruso A, Fernandez-Real JM, Vendrell J, Fernandez-Veledo S.	Microbiome	10.1186/s40168-022-01306-y	2022
Pathogenicity	Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.	Ring C, Klopfleisch R, Dahlke K, Basic M, Bleich A, Blaut M.	Gut Microbes	10.1080/19490976.2018.1511663	2019
Metabolism	Short-Chain Cello-oligosaccharides: Intensification and Scale-up of Their Enzymatic Production and Selective Growth Promotion among Probiotic Bacteria.	Zhong C, Ukowitz C, Domig KJ, Nidetzky B.	J Agric Food Chem	10.1021/acs.jafc.0c02660	2020
Metabolism	Gene expression in the chicken caecum is dependent on microbiota composition.	Volf J, Polansky O, Sekelova Z, Velge P, Schouler C, Kaspers B, Rychlik I.	Vet Res	10.1186/s13567-017-0493-7	2017
Metabolism	Clostridium ramosum regulates enterochromaffin cell development and serotonin release.	Mandic AD, Woting A, Jaenicke T, Sander A, Sabrowski W, Rolle-Kampcyk U, von Bergen M, Blaut M.	Sci Rep	10.1038/s41598-018-38018-z	2019
	Association of germ-free mice with a simplified human intestinal microbiota results in a shortened intestine.	Slezak K, Krupova Z, Rabot S, Loh G, Levenez F, Descamps A, Lepage P, Dore J, Bellier S, Blaut M.	Gut Microbes	10.4161/gmic.28203	2014
Metabolism	Both pH and carbon flux influence the level of rubredoxin in Clostridium butyricum.	Guedon E, Gerard P, Charpentier B, Branlant C, Petitdemange H.	Curr Microbiol	10.1007/s002840010334	2001
Enzymology	Comprehensive Laboratory Evaluation of a Specific Lateral Flow Assay for the Presumptive Identification of Francisella tularensis in Suspicious White Powders and Aerosol Samples.	Pillai SP, DePalma L, Prentice KW, Ramage JG, Chapman C, Sarwar J, Parameswaran N, Petersen J, Yockey B, Young J, Singh A, Pillai CA, Manickam G, Thirunavkkarasu N, Avila JR, Sharma S, Morse SA, Venkateswaran K, Anderson K, Hodge DR.	Health Secur	10.1089/hs.2019.0151	2020
Genetics	Genomic Characterization of Sulphite Reducing Bacteria Isolated From the Dairy Production Chain.	Doyle CJ, O'Toole PW, Cotter PD.	Front Microbiol	10.3389/fmicb.2018.01507	2018
Metabolism	Effect of glucose on glycerol metabolism by Clostridium butyricum DSM 5431.	Abbad-Andaloussi S, Amine J, Gerard P, Petitdemange H.	J Appl Microbiol	10.1046/j.1365-2672.1998.00374.x	1998
Enzymology	Comprehensive Laboratory Evaluation of a Lateral Flow Assay for the Detection of Yersinia pestis.	Prentice KW, DePalma L, Ramage JG, Sarwar J, Parameswaran N, Petersen J, Yockey B, Young J, Joshi M, Thirunavvukarasu N, Singh A, Chapman C, Avila JR, Pillai CA, Manickam G, Sharma SK, Morse SA, Venkateswaran KV, Anderson K, Hodge DR, Pillai SP.	Health Secur	10.1089/hs.2019.0094	2019
Metabolism	Comparison of the energetic efficiencies of hydrogen and oxychemicals formation in Klebsiella pneumoniae and Clostridium butyricum during anaerobic growth on glycerol.	Solomon BO, Zeng AP, Biebl H, Schlieker H, Posten C, Deckwer WD.	J Biotechnol	10.1016/0168-1656(94)00148-6	1995
Metabolism	Clostridium ramosum promotes high-fat diet-induced obesity in gnotobiotic mouse models.	Woting A, Pfeiffer N, Loh G, Klaus S, Blaut M.	mBio	10.1128/mbio.01530-14	2014
	Developing standards for the microbiome field.	Amos GCA, Logan A, Anwar S, Fritzsche M, Mate R, Bleazard T, Rijpkema S.	Microbiome	10.1186/s40168-020-00856-3	2020
Metabolism	The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro.	Krause JL, Schape SS, Schattenberg F, Muller S, Ackermann G, Rolle-Kampczyk UE, Jehmlich N, Pierzchalski A, von Bergen M, Herberth G.	Front Microbiol	10.3389/fmicb.2020.00755	2020
	Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice.	Ganesh BP, Klopfleisch R, Loh G, Blaut M.	PLoS One	10.1371/journal.pone.0074963	2013
Enzymology	Comprehensive Laboratory Evaluation of a Highly Specific Lateral Flow Assay for the Presumptive Identification of Bacillus anthracis Spores in Suspicious White Powders and Environmental Samples.	Ramage JG, Prentice KW, DePalma L, Venkateswaran KS, Chivukula S, Chapman C, Bell M, Datta S, Singh A, Hoffmaster A, Sarwar J, Parameswaran N, Joshi M, Thirunavkkarasu N, Krishnan V, Morse S, Avila JR, Sharma S, Estacio PL, Stanker L, Hodge DR, Pillai SP.	Health Secur	10.1089/hs.2016.0041	2016
	Isolation and Characterization of Clostridium butyricum DSM 5431 Mutants with Increased Resistance to 1,3-Propanediol and Altered Production of Acids.	Abbad-Andaloussi S, Manginot-Durr C, Amine J, Petitdemange E, Petitdemange H.	Appl Environ Microbiol	10.1128/aem.61.12.4413-4417.1995	1995
Pathogenicity	The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut.	Elzinga J, van der Oost J, de Vos WM, Smidt H.	Microbiol Mol Biol Rev	10.1128/mmbr.00054-18	2019
	Alleviation of high fat diet-induced obesity by oligofructose in gnotobiotic mice is independent of presence of Bifidobacterium longum.	Woting A, Pfeiffer N, Hanske L, Loh G, Klaus S, Blaut M.	Mol Nutr Food Res	10.1002/mnfr.201500249	2015
	Microfluidic Fabrication of Hyaluronic Acid-Cysteine-Modified Chitosan Microspheres for CD44-Targeted Probiotic Delivery in Colitis Treatment.	Qiao F, Luo Y, Lei P, Wang S, Duan Z, Cui H, Liu T, Yi H, De Souza C, Xuan G, Mao X, Ma Z, Zhang L, Lin K.	ACS Appl Mater Interfaces	10.1021/acsami.5c10456	2025
	Dissolving microneedles enabled delivery of Oxaliplatin- sodium butyrate loaded outer membrane vesicles against rectal cancer.	Jian C, Zhanbo Q, Yinhang W, Yating X, Bo H, Yingchen W, Jing Z, Zefeng W, Zheng W, Xiang Y, Shuwen H.	J Transl Med	10.1186/s12967-025-06921-5	2025
	Oral Clostridium butyricum on mice endometritis through uterine microbiome and metabolic alternations	Hagihara M, Ariyoshi T, Eguchi S, Oka K, Takahashi M, Kato H, Shibata Y, Umemura T, Mori T, Miyazaki N, Hirai J, Asai N, Mori N, Mikamo H.	Front Microbiol		2024
Enzymology	In situ identifying sennoside A-reducing bacteria guilds in human gut microbiota via enzymatic activity visualization.	Zhai C, Liu X, Liu Z, Ma H, Li H, Gong Y, Li X, Wang Y, Zhang N, Zhang H, Luo G, Wang Y, Gao X.	Gut Microbes	10.1080/19490976.2025.2560598	2025
	Combination of probiotics enhancing butyrogenesis in colonic microbiota model of patients with ulcerative colitis.	Inokuma K, Sasaki D, Shintani T, Inoue J, Oyama K, Noda Y, Maeda T, Yamada R, Matsuki Y, Kodama Y, Kondo A.	Appl Microbiol Biotechnol	10.1007/s00253-025-13424-2	2025
	Impact of Clostridium butyricum HADIG-CB003 dietary supplementation on the gut microbiota of Kunming mice.	Pang Y, Xu X, Li D, Ge Y, Liang J, Xiong X, Wen S, Li X, Wang Y, Li X, Tan G, Lin Y.	Appl Microbiol Biotechnol	10.1007/s00253-025-13546-7	2025
	Characterisation of anhydro-sialic acid transporters from mucosa-associated bacteria.	Wu Y, Bell A, Thomas GH, Bolam DN, Sargent F, Juge N, Palmer T, Severi E.	Microbiology (Reading)	10.1099/mic.0.001448	2024
	Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120.	Hagihara M, Yamashita M, Ariyoshi T, Minemura A, Yoshida C, Higashi S, Oka K, Takahashi M, Ota A, Maenaka A, Iwasaki K, Hirai J, Shibata Y, Umemura T, Mori T, Kato H, Asai N, Mikamo H.	iScience	10.1016/j.isci.2025.113502	2025
	Evaluation of the Effect of Probiotic Supplementation on Intestinal Barrier Integrity and Epithelial Damage in Colitis Disease: A Systematic Review.	Sivri D, Seref B, Sare Bulut M, Gezmen Karadag M.	Nutr Rev	10.1093/nutrit/nuae180	2025
	Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy.	Kvakova M, Kamlarova A, Stofilova J, Benetinova V, Bertkova I.	World J Gastroenterol	10.3748/wjg.v28.i27.3370	2022
	Evaluation of probiotic growth stimulation using prebiotic ingredients to optimize compounds for in ovo delivery.	Akhavan N, Hrynkiewicz K, Thiem D, Randazzo C, Walsh AM, Guinan KJ, O'Sullivan JT, Stadnicka K.	Front Microbiol	10.3389/fmicb.2023.1242027	2023
	Targeting the gut microbiota: a new strategy for colorectal cancer treatment.	Hu Y, Zhou P, Deng K, Zhou Y, Hu K.	J Transl Med	10.1186/s12967-024-05671-0	2024
	Clostridium butyricum inhibits epithelial-mesenchymal transition of intestinal carcinogenesis through downregulating METTL3.	Zhang K, Dong Y, Li M, Zhang W, Ding Y, Wang X, Chen D, Liu T, Wang B, Cao H, Zhong W.	Cancer Sci	10.1111/cas.15839	2023
Enzymology	Clostridium butyricum Prazmowski can degrade and utilize resistant starch via a set of synergistically acting enzymes.	Pickens TL, Cockburn DW.	mSphere	10.1128/msphere.00566-23	2024
	Clostridium butyricum and Clostridium tyrobutyricum: angel or devil for necrotizing enterocolitis?	Tao R, Zong G, Pan Y, Li H, Cheng P, Deng R, Chen W, Wang A, Xia S, Tang W, Lu Y, Wei Z.	mSystems	10.1128/msystems.00732-23	2023
	The protective effects of dietary Clostridium butyricum supplementation on hepatic ischemia reperfusion injury in rats.	Yang X, Yu H, Wei J, Wei Q, Huang H, Chen J, Li J, Yu S.	Acta Cir Bras	10.1590/acb370904	2022
	Fermenting kale (Brassica oleracea L.) enhances its functional food properties by increasing accessibility of key phytochemicals and reducing antinutritional factors.	Subedi U, Raychaudhuri S, Fan S, Ogedengbe O, Obanda DN.	Food Sci Nutr	10.1002/fsn3.4195	2024
Pathogenicity	Protective Effect of Clostridium butyricum on Escherichia coli-Induced Endometritis in Mice via Ameliorating Endometrial Barrier and Inhibiting Inflammatory Response.	Wang K, Wang K, Wang J, Yu F, Ye C.	Microbiol Spectr	10.1128/spectrum.03286-22	2022
	Epigenetic programming mediates abnormal gut microbiota and disease susceptibility in offspring with prenatal dexamethasone exposure.	Lu X, Chen B, Xu D, Hu W, Wang X, Dai Y, Wang Q, Peng Y, Chen K, Zhao D, Wang H.	Cell Rep Med	10.1016/j.xcrm.2024.101398	2024
	The Encapsulation Strategies for Targeted Delivery of Probiotics in Preventing and Treating Colorectal Cancer: A Review.	Zhong H, Jiang J, Hussain M, Zhang H, Chen L, Guan R.	Adv Sci (Weinh)	10.1002/advs.202500304	2025
	Effect of Clostridium butyricum and Butyrate on Intestinal Barrier Functions: Study of a Rat Model of Severe Acute Pancreatitis With Intra-Abdominal Hypertension.	Zhao HB, Jia L, Yan QQ, Deng Q, Wei B.	Front Physiol	10.3389/fphys.2020.561061	2020
	Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation.	Zhao H, Zhou Y, Xu J, Zhang Y, Wang H, Zhao C, Huang H, Yang J, Huang C, Li Y, Wang L, Nie Y.	J Transl Med	10.1186/s12967-024-05122-w	2024
Phylogeny	Maternal sucralose intake alters gut microbiota of offspring and exacerbates hepatic steatosis in adulthood.	Dai X, Guo Z, Chen D, Li L, Song X, Liu T, Jin G, Li Y, Liu Y, Ajiguli A, Yang C, Wang B, Cao H.	Gut Microbes	10.1080/19490976.2020.1738187	2020
	In Situ Bioorthogonal Conjugation of Delivered Bacteria with Gut Inhabitants for Enhancing Probiotics Colonization.	Song WF, Yao WQ, Chen QW, Zheng D, Han ZY, Zhang XZ.	ACS Cent Sci	10.1021/acscentsci.2c00533	2022
	Probiotics Improve Eating Disorders in Mandarin Fish (Siniperca chuatsi) Induced by a Pellet Feed Diet via Stimulating Immunity and Regulating Gut Microbiota.	Chen X, Yi H, Liu S, Zhang Y, Su Y, Liu X, Bi S, Lai H, Zeng Z, Li G.	Microorganisms	10.3390/microorganisms9061288	2021
Pathogenicity	Alterations of gut microbiome accelerate multiple myeloma progression by increasing the relative abundances of nitrogen-recycling bacteria.	Jian X, Zhu Y, Ouyang J, Wang Y, Lei Q, Xia J, Guan Y, Zhang J, Guo J, He Y, Wang J, Li J, Lin J, Su M, Li G, Wu M, Qiu L, Xiang J, Xie L, Jia W, Zhou W, Zhou W.	Microbiome	10.1186/s40168-020-00854-5	2020
	Microbiota Manipulation by Probiotics Administration as Emerging Tool in Cancer Prevention and Therapy.	Panebianco C, Latiano T, Pazienza V.	Front Oncol	10.3389/fonc.2020.00679	2020
	Probiotics: A Promising Candidate for Management of Colorectal Cancer.	Tripathy A, Dash J, Kancharla S, Kolli P, Mahajan D, Senapati S, Jena MK.	Cancers (Basel)	10.3390/cancers13133178	2021
	Identification of novel linear megaplasmids carrying a ß-lactamase gene in neurotoxigenic Clostridium butyricum type E strains.	Franciosa G, Scalfaro C, Di Bonito P, Vitale M, Aureli P.	PLoS One	10.1371/journal.pone.0021706	2011
Metabolism	Butyrate-producing human gut symbiont, Clostridium butyricum, and its role in health and disease.	Stoeva MK, Garcia-So J, Justice N, Myers J, Tyagi S, Nemchek M, McMurdie PJ, Kolterman O, Eid J.	Gut Microbes	10.1080/19490976.2021.1907272	2021
Metabolism	Enterobacteriaceae Growth Promotion by Intestinal Acylcarnitines, a Biomarker of Dysbiosis in Inflammatory Bowel Disease.	Lemons JMS, Conrad M, Tanes C, Chen J, Friedman ES, Roggiani M, Curry D, Chau L, Hecht AL, Harling L, Vales J, Kachelries KE, Baldassano RN, Goulian M, Bittinger K, Master SR, Liu L, Wu GD.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2023.09.005	2024
Metabolism	Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation.	Wlodarska M, Luo C, Kolde R, d'Hennezel E, Annand JW, Heim CE, Krastel P, Schmitt EK, Omar AS, Creasey EA, Garner AL, Mohammadi S, O'Connell DJ, Abubucker S, Arthur TD, Franzosa EA, Huttenhower C, Murphy LO, Haiser HJ, Vlamakis H, Porter JA, Xavier RJ.	Cell Host Microbe	10.1016/j.chom.2017.06.007	2017
	Ginsenoside Rg3 enriches SCFA-producing commensal bacteria to confer protection against enteric viral infection via the cGAS-STING-type I IFN axis.	Wang G, Liu J, Zhang Y, Xie J, Chen S, Shi Y, Shi F, Zhu SJ.	ISME J	10.1038/s41396-023-01541-7	2023
	GS-2: A Novel Broad-Spectrum Agent for Environmental Microbial Control.	Mayfosh AJ, Day ZI, Unsworth NB, Liu CQ, Gupta R, Haynes S, Abraham R, Abraham S, Shaw ZL, Walia S, Elbourne A, Hulett MD, Rau TF.	Biomolecules	10.3390/biom12091293	2022
Metabolism	The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome.	Markowiak-Kopec P, Slizewska K.	Nutrients	10.3390/nu12041107	2020
	Role of Gut Microbiota and Probiotics in Colorectal Cancer: Onset and Progression.	Torres-Maravilla E, Boucard AS, Mohseni AH, Taghinezhad-S S, Cortes-Perez NG, Bermudez-Humaran LG.	Microorganisms	10.3390/microorganisms9051021	2021
	A Sensitive and Accurate Recombinase Polymerase Amplification Assay for Detection of the Primary Bacterial Pathogens Causing Bovine Respiratory Disease.	Conrad CC, Daher RK, Stanford K, Amoako KK, Boissinot M, Bergeron MG, Alexander T, Cook S, Ralston B, Zaheer R, Niu YD, McAllister T.	Front Vet Sci	10.3389/fvets.2020.00208	2020
	The Intestinal Microbiome Primes Host Innate Immunity against Enteric Virus Systemic Infection through Type I Interferon.	Yang XL, Wang G, Xie JY, Li H, Chen SX, Liu W, Zhu SJ.	mBio	10.1128/mbio.00366-21	2021
	Transfer of neurotoxigenicity from Clostridium butyricum to a nontoxigenic Clostridium botulinum type E-like strain.	Zhou Y, Sugiyama H, Johnson EA.	Appl Environ Microbiol	10.1128/aem.59.11.3825-3831.1993	1993
Biotechnology	Multiplex PCR for detection of botulinum neurotoxin-producing clostridia in clinical, food, and environmental samples.	De Medici D, Anniballi F, Wyatt GM, Lindstrom M, Messelhausser U, Aldus CF, Delibato E, Korkeala H, Peck MW, Fenicia L.	Appl Environ Microbiol	10.1128/aem.00805-09	2009
	Bacteria and Bacterial Components as Natural Bio-Nanocarriers for Drug and Gene Delivery Systems in Cancer Therapy.	Zong R, Ruan H, Liu C, Fan S, Li J.	Pharmaceutics	10.3390/pharmaceutics15102490	2023
Enzymology	SYBR green real-time PCR method to detect Clostridium botulinum type A.	Fenicia L, Anniballi F, De Medici D, Delibato E, Aureli P.	Appl Environ Microbiol	10.1128/aem.02234-06	2007
	Genetic confirmation of identities of neurotoxigenic Clostridium baratii and Clostridium butyricum implicated as agents of infant botulism.	Suen JC, Hatheway CL, Steigerwalt AG, Brenner DJ.	J Clin Microbiol	10.1128/jcm.26.10.2191-2192.1988	1988
	Comparison of toxins of Clostridium butyricum and Clostridium botulinum type E.	Gimenez JA, Sugiyama H.	Infect Immun	10.1128/iai.56.4.926-929.1988	1988
	Cloning, nucleotide sequence, and expression of the gene encoding the bacteriocin boticin B from Clostridium botulinum strain 213B.	Dineen SS, Bradshaw M, Johnson EA.	Appl Environ Microbiol	10.1128/aem.66.12.5480-5483.2000	2000
Phylogeny	Novel endophytic nitrogen-fixing clostridia from the grass Miscanthus sinensis as revealed by terminal restriction fragment length polymorphism analysis.	Miyamoto T, Kawahara M, Minamisawa K.	Appl Environ Microbiol	10.1128/aem.70.11.6580-6586.2004	2004
Pathogenicity	Effects of solvents and alcohols on the polar lipid composition of Clostridium butyricum under conditions of controlled lipid chain composition.	MacDonald DL, Goldfine H.	Appl Environ Microbiol	10.1128/aem.57.12.3517-3521.1991	1991
Phylogeny	Development of a combined selection and enrichment PCR procedure for Clostridium botulinum Types B, E, and F and its use to determine prevalence in fecal samples from slaughtered pigs.	Dahlenborg M, Borch E, Radstrom P.	Appl Environ Microbiol	10.1128/aem.67.10.4781-4788.2001	2001
Enzymology	First case of type E wound botulism diagnosed using real-time PCR.	Artin I, Bjorkman P, Cronqvist J, Radstrom P, Holst E.	J Clin Microbiol	10.1128/jcm.01192-07	2007
Metabolism	Biosynthesis of phospholipids in Clostridium butyricum: kinetics of synthesis of plasmalogens and the glycerol acetal of ethanolamine plasmalogen.	Koga Y, Goldfine H.	J Bacteriol	10.1128/jb.159.2.597-604.1984	1984
Metabolism	Nonspecific phospholipase C of Listeria monocytogenes: activity on phospholipids in Triton X-100-mixed micelles and in biological membranes.	Goldfine H, Johnston NC, Knob C.	J Bacteriol	10.1128/jb.175.14.4298-4306.1993	1993
Metabolism	2-keto-3-deoxygluconate, an intermediate in the fermentation of gluconate by clostridia.	Bender R, Andreesen JR, Gottschalk G.	J Bacteriol	10.1128/jb.107.2.570-573.1971	1971
Phylogeny	Electrophoretic study of Clostridium species.	Cato EP, Hash DE, Holdeman LV, Moore WE.	J Clin Microbiol	10.1128/jcm.15.4.688-702.1982	1982
	Liquid chromatographic procedure for fermentation product analysis in the identification of anaerobic bacteria.	Ehrlich GG, Goerlitz DF, Bourell JH, Eisen GV, Godsy EM.	Appl Environ Microbiol	10.1128/aem.42.5.878-885.1981	1981
Enzymology	Identification of Clostridium botulinum, Clostridium argentinense, and related organisms by cellular fatty acid analysis.	Ghanem FM, Ridpath AC, Moore WE, Moore LV.	J Clin Microbiol	10.1128/jcm.29.6.1114-1124.1991	1991
Cultivation	Comparison of media in the Anaerobe-Tek and Presumpto plate systems and evaluation of the Anaerobe-Tek system for identification of commonly encountered anaerobes.	Lombard GL, Whaley DN, Dowell VR.	J Clin Microbiol	10.1128/jcm.16.6.1066-1072.1982	1982
Metabolism	Genetic analysis of type E botulinum toxin-producing Clostridium butyricum strains.	Wang X, Maegawa T, Karasawa T, Kozaki S, Tsukamoto K, Gyobu Y, Yamakawa K, Oguma K, Sakaguchi Y, Nakamura S.	Appl Environ Microbiol	10.1128/aem.66.11.4992-4997.2000	2000
	Isolation and Evaluation of Potential Use of Prebiotics-Utilizing Butyrate-Producing Bacteria in Nibea coibor.	Li Z, Tran NT, Zhang M, Li Z, Yang W, Wang S, Hu Z, Li S.	Aquac Nutr	10.1155/anu/4679037	2025
Metabolism	Reactivation of latent HIV-1 by a wide variety of butyric acid-producing bacteria.	Imai K, Yamada K, Tamura M, Ochiai K, Okamoto T.	Cell Mol Life Sci	10.1007/s00018-012-0936-2	2012
	Enhancement of Vaccine-Induced T-Cell Responses by Probiotics in Calves.	Ikehata M, Okagawa T, Nakamura H, Maekawa N, Suzuki Y, Murata S, Ohashi K, Konnai S.	Vaccines (Basel)	10.3390/vaccines13111120	2025
	Effect of retrogradation, pancreatin digestion and amylose/amylopectin ratio on the fermentation of starch by Clostridium butyricum (NCIMB 7423)	Reid CA, Hillman K, Henderson C.	J Sci Food Agric	10.1002/(sici)1097-0010(199802)76:2<221::aid-jsfa935>3.0.co;2-o	1998
Phylogeny	Characterization of bacterial communities in feces from healthy elderly volunteers and hospitalized elderly patients by using real-time PCR and effects of antibiotic treatment on the fecal microbiota.	Bartosch S, Fite A, Macfarlane GT, McMurdo ME.	Appl Environ Microbiol	10.1128/aem.70.6.3575-3581.2004	2004
Metabolism	Genomic sequence and characterization of the virulent bacteriophage phiCTP1 from Clostridium tyrobutyricum and heterologous expression of its endolysin.	Mayer MJ, Payne J, Gasson MJ, Narbad A.	Appl Environ Microbiol	10.1128/aem.00989-10	2010
Enzymology	Genomic sequence of bacteriophage ATCC 8074-B1 and activity of its endolysin and engineered variants against Clostridium sporogenes.	Mayer MJ, Gasson MJ, Narbad A.	Appl Environ Microbiol	10.1128/aem.07884-11	2012
Enzymology	Rapid affinity immunochromatography column-based tests for sensitive detection of Clostridium botulinum neurotoxins and Escherichia coli O157.	Brunt J, Webb MD, Peck MW.	Appl Environ Microbiol	10.1128/aem.03059-09	2010
	Synthetic microbial consortia for the treatment of Clostridioides difficile infection in mice model.	Liu J, Zhu W, Lessing DJ, Chu W.	Microb Biotechnol	10.1111/1751-7915.14333	2023
	Targeting Gut Microbial Biofilms-A Key to Hinder Colon Carcinogenesis?	Chew SS, Tan LT, Law JW, Pusparajah P, Goh BH, Ab Mutalib NS, Lee LH.	Cancers (Basel)	10.3390/cancers12082272	2020
	Growth Limiting pH, Water Activity, and Temperature for Neurotoxigenic Strains of Clostridium butyricum.	Ghoddusi HB, Sherburn RE, Aboaba OO.	ISRN Microbiol	10.1155/2013/731430	2013
Metabolism	The stereoisomers of alpha epsilon-diaminopimelic acid. II. Their distribution in the bacterial order Actinomycetales and in certain Eubacteriales.	HOARE DS, WORK E.	Biochem J	10.1042/bj0650441	1957
Metabolism	The stereoisomers of alpha epsilon-diaminopimelic acid. III. Properties and distribution of diaminopimelic acid racemase, an enzyme causing interconversion of the LL and meso isomers.	ANTIA M, HOARE DS, WORK E.	Biochem J	10.1042/bj0650448	1957
Genetics	Functional and Genomic Insights into Clostridium butyricum MCC0233: Probiotic Features and Safety Assessment.	Pisu V, Dhanorkar A, Shetty D, Wagh S, Dagar SS, Kapse N, Dhakephalkar PK.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10842-6	2025
	Integrative Dynamic Proteomics and Acyl-Proteomics Analyses in Clostridium butyricum.	Li G, Yang Q, Liu X, Tang Y, Tian N, Wang D, Zhu X, Ren B, Tu Z, Chen Y, Huang J, Tan M, Xu JY.	J Proteome Res	10.1021/acs.jproteome.5c00492	2025
	Pectin/arabinoxylan dietary polysaccharide microcapsule encapsulated with Clostridium butyricum for targeted delivery in colitis treatment	Wang W, Tu F, Yang Z, Gu M, Wang Y, Gao Z, Jiang L.	Carbohydrate polymers.		2025
	Ameliorative effects of Clostridium butyricum metabolites on growth, oxidative stress, and intestinal health in bullfrogs fed high soybean meal diets	Wu X, Fu S, Hu Y, Zhu B, Yang M, Dai J.	Aquac Int		2025
	Clostridium Butyricum and Bifidobacterium Supplementation Ameliorates Gut Dysbiosis and Cognitive-Anxiety Behaviors in Preterm Mice.	Qin D, Li H, Zang X, Yang S, Song L, Chen M, Xu G, Zhang S.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10836-4	2025
	Clostridium butyricum metabolites mitigate inflammatory responses in Ctenopharyngodon idella post-overwintering and enhance resistance to Aeromonas hydrophila.	Wang S, Hu Y, Cai M, Shi Y, Yue Y, Zhong L, Fu G.	Fish Shellfish Immunol	10.1016/j.fsi.2025.110967	2026
	Probiotic Prophylaxis With Clostridium butyricum for Postoperative Infections Following Lung Resection: A Propensity Score-Weighted Analysis.	Murakami J, Tanaka T, Shimokawa M, Yoshimine S, Yamamoto N, Kurazumi H, Hamano K.	Ann Thorac Surg	10.1016/j.athoracsur.2025.09.015	2025
	Clostridium butyricum attenuates radiation-induced bone loss through gut microbiota and immune regulation in mice.	Lv J, Chen H, Ni Y, Zhang Y, Huang X.	Microbiol Res	10.1016/j.micres.2025.128352	2026
	Expression and characterization of a Clostridium Butyricum esterase from pit cellar of Chinese liquor and its potential in flavor ester synthesis.	Wang C, Lamu GR, Wang X, Wen X, Li L.	Arch Microbiol	10.1007/s00203-025-04433-w	2025
	Clostridium butyricum Restores Intestinal Barrier Integrity via the IL-22/Reg3 Pathway Following Traumatic Brain Injury in Mice.	Liu M, Pang Y, Xu L, Ji T, Yang J, Huang D, Cheng M, Chen M, Huang B, Xu S, Zhao K, Zhang J, Yokomizo T, Zhong C.	J Neurotrauma	10.1177/08977151251367404	2025
	Effect of active and heat-killed Clostridium butyricum on in vitro gas production, ruminal fermentation, and microbiota varying with pH levels.	Zhang X, Zhang Z, Zhu H, Hu G, Xin H, Liu J, Lin X, Xie X, Jiao P.	Anim Biosci	10.5713/ab.24.0913	2025
Genetics	Fish-Derived Clostridium butyricum LZK-08: Genomic Insights and Probiotic Evaluation in Largemouth Bass.	Liu Z, Guo J, Su Q, Feng S, Zhang X, Zhang Y, Yang G, Chang X, Meng X.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10721-0	2025
Genetics	Comparative genomics of Clostridium butyricum reveals a conserved genome architecture and novel virulence-related gene clusters.	Anderson OH, Chong JPJ, Thomas GH.	Microb Genom	10.1099/mgen.0.001477	2025
	Untangling metabolic interactions of a nongrowing, hydrogen producing synthetic coculture through a multispecies metabolic flux analysis.	Morales-Mendivelso DF, Garcia-Pena EI, Aranda-Barradas JS, Gonzalez-Garcia RA, Salgado-Manjarrez E.	Bioresour Technol	10.1016/j.biortech.2025.133275	2026
Transcriptome	Mechanism of CaCO3 efficiently promoting hydrogen production by Clostridium butyricum BJ-10.	Huang T, Zhao R, Lin Y, Zhu L, Zhang Q, Qin J, Zhu L, Tian Y, Liu H, Wang C, Guan G.	J Appl Microbiol	10.1093/jambio/lxaf206	2025
	Effects of Clostridium butyricum on Growth Performance, Health Status, and Metabolic Response of Pre-Weaning Angus Calves.	Wang J, Yu X, Zhang Y, Yang Y, Sun Y, Zhang Y.	Animals (Basel)	10.3390/ani15162332	2025
	Tumor-resident probiotic Clostridium butyricum improves aPD-1 efficacy in colorectal cancer models by inhibiting IL-6-mediated immunosuppression.	Xie M, Yuan K, Zhang Y, Zhang Y, Zhang R, Gao J, Wei W, Jiang L, Li T, Ding Y, Wang L, Lin Y, Wong CC, Yu J.	Cancer Cell	10.1016/j.ccell.2025.07.012	2025
	Parishin A reduces hepatic encephalopathy via gut microbiota increasing the activity of intestinal EAAT3 to reduce blood ammonia.	Lu JY, Zuo HT, Feng R, Chen YL, Ye ML, Xu H, Hu JC, Song JY, Zhao Y, Wang JY, Jin JY, Yuan TF, Wang WX, Zhao YF, Tu YM, Wei LY, Li MY, Cong B, Jiang JD, Wang Y.	Pharmacol Res	10.1016/j.phrs.2025.108030	2025
	Effect of fermentation products of butyricum and fulvic acid in enhancing growth, antioxidant capacity, and physiological condition of large yellow croaker (Larimichthys crocea) under high temperature	Huang C, Zhu T, Lv H, Li W, Yin X, Chu Z, Park J, Hur J, Gao Y.	Aquac Int		2025
	Pectin/arabinoxylan dietary polysaccharide microcapsule encapsulated with Clostridium butyricum for targeted delivery in colitis treatment.	Wang W, Tu F, Yang Z, Gu M, Wang Y, Gao Z, Jiang L.	Carbohydr Polym	10.1016/j.carbpol.2025.123971	2025
	Effect of Clostridium butyricum and antibiotics using simultaneous simple suspension in mice with Clostridioides difficile infection.	Kato H, Hagihara M, Shiraishi C, Asai Y, Mikamo H, Iwamoto T.	Exp Mol Pathol	10.1016/j.yexmp.2025.104979	2025
	Clostridium butyricum Promotes Bone Remodeling by Activating Inflammatory Genes in Mice.	Jia Y, Xu L, Ju Z, Song M, Zhou Y, Li B, Wang F, Lin H, Sun S, Li H.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10659-3	2025
	Automated Microchannel Resistance Readout of Immunorecognition via Programmable Nuclease Mediation for On-Site Biosensing.	Lu P, Zhan C, Feng Y, Li C, Pan L, Zheng W, Chen Y.	Anal Chem	10.1021/acs.analchem.5c05142	2025
	The Time Reliable Effect of Probiotic Clostridium butyricum on the Growth of Spotted Sea Bass (Lateolabrax maculatus).	Deng Y, Xu L, Yang K, Lin Z, Zang S, Jiang K, Li W, Ibrahim NA, Ma H, Cheng C, Feng J.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10652-w	2025
Phylogeny	Optimization of fermentation conditions for enhanced hydrogen production by newly isolated Clostridium butyricum ZYZCB strain.	Gu P, Zhou Y, Wang D, Tian Y, Wang Y, Su H.	J Appl Microbiol	10.1093/jambio/lxaf096	2025
	Clostridium butyricum protects the ileal barrier in mice by regulating the farnesoid X receptor signaling pathway.	Wang H, Hou L, Chen X, Gui L, Jiang W, Tang W.	Int J Biochem Cell Biol	10.1016/j.biocel.2025.106798	2025
	Clostridium butyricum Regulates the Inflammatory and Immunoregulatory Pathway Through NFKB1 in Colorectal Cancer Treatment.	Zhou K, Yu Y, Li W, Zhu M.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10547-w	2025
	Clostridium butyricum: a promising approach to enhancing intestinal health in poultry.	Tang X, Zeng Y, Li M.	Front Vet Sci	10.3389/fvets.2025.1544519	2025
	Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and Bifidobacterium longum W11.	Bertuccioli A, Sisti D, Lazzerini N, Palazzi CM, Zonzini GB, Ragazzini M, Belli A.	Front Med (Lausanne)	10.3389/fmed.2025.1604319	2025
	EFFECTS OF CLOSTRIDIUM BUTYRICUM SUPPLEMENTATION ON FECAL MICROBIOTA AND METABOLITES IN CAPTIVE RED KANGAROO (MACROPUS RUFUS).	Yoshimoto Y, Ichinohe N, Liu H, Nagata N, Inoue R, Yamamoto Y, Nagaoka K.	J Zoo Wildl Med	10.1638/2024-0079	2025
Pathogenicity	Microbial dynamics in a swine wastewater treatment plant and prediction of potential hosts of antibiotic resistance genes.	Pereira AR, de Moraes LAG, Rosse I, de Aquino SF, Silva SQ.	Int J Hyg Environ Health	10.1016/j.ijheh.2025.114698	2025
	Combination therapy with levofloxacin and the probiotic Clostridium butyricum MIYAIRI 588 enhances immune checkpoint inhibitor efficacy.	Tajima K, Hosonuma M, Funayama E, Isobe J, Baba Y, Murayama M, Narikawa Y, Toyoda H, Tsurui T, Maruyama Y, Sasaki A, Amari Y, Yamazaki Y, Nakashima R, Shida M, Sasaki A, Sambe T, Wada S, Tsuji M, Kiuchi Y, Kobayashi S, Kuramasu A, Tsunoda T, Mori M, Koyanagi K, Yoshimura K.	Int J Cancer	10.1002/ijc.35472	2025
	Impact of Clostridium butyricum on growth performance, ruminal fermentation, bacterial communities, and immune responses of goats fed milk replacer with varying fat levels	Zhang Z, Ding W, Zhu H, Zuo Y, Hu G, Liu J, Xin H, Lin X, Xie X, Jiao P.	Anim Feed Sci Technol		2025
	A neonate with meningitis caused by probiotic-related Clostridium butyricum.	Jiang Y, Yang J, Liu Y, Liu Y, Zhou W, Yang B, Hu B, Wu H.	Int J Infect Dis	10.1016/j.ijid.2025.107900	2025
	Oral Administrations of Short-Chain Fatty Acids or Probiotics Extend the Survival Times and Mitigate the Neuropathological Damages in the Scrapie-Infected Hamsters.	Wang Y, Liang DL, Cao RD, A R, Zeng JF, Xu B, Li JZ, Zhang WW, Gao LP, Xiao K, Dong XP, Shi Q.	Mol Neurobiol	10.1007/s12035-025-05386-3	2025
	Engineered Clostridium butyricum-pMTL007-GLP-1 Delays Neurodegeneration in Prnp-SNCA*A53T Transgenic Mice Model by Suppressing Astrocyte Senescence.	Liao B, Ding L, Chen W, Yue M, Wang Y, Hong D, Chen T, Fang X.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10638-8	2025
	Clostridium butyricum and its metabolites regulate macrophage polarization through miR-146a to antagonize gouty arthritis.	Song S, Shi K, Fan M, Wen X, Li J, Guo Y, Lou Y, Chen F, Wang J, Huang L, Wen C, Shao T.	J Adv Res	10.1016/j.jare.2025.05.036	2025
	Gut microbiota biomarkers enable stratified nutritional approaches for functional constipation subtypes in children with comorbidities.	Huang C, Wang C, Wu B, Kong W, Wan L, Wu H, Huang Y, Wang X, Zeng Y, Liu H.	Nutrition	10.1016/j.nut.2025.112949	2026
	Clostridium butyricum-induced balance in colonic retinol metabolism and short-chain fatty acid levels inhibit IgA-related mucosal immunity and relieve colitis developments.	Xu J, Xu H, Li J, Huang W, Li Y, Guo X, Zhu M, Peng Y, Zhou Y, Nie Y.	Microbiol Res	10.1016/j.micres.2025.128203	2025
	Safety of Clostridium butyricum TO-A as a novel food pursuant to Regulation (EU) 2015/2283.	EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Camara M, Castenmiller J, De Henauw S, Jos A, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Aguilera-Gomez M, Cubadda F, Frenzel T, Heinonen M, Knutsen HK, Neuhauser-Berthold M, Poulsen M, Prieto Maradona M, Schlatter JR, Siskos A, van Loveren H, Ackerl R, Kagkli DM, Hirsch-Ernst KI.	EFSA J	10.2903/j.efsa.2025.9371	2025
	Comparative effectiveness and safety of probiotics with psychotropic potential in mental health benefits in irritable bowel syndrome: a systematic review and network meta-analysis.	Rokkas T, Ekmektzoglou K, Tsanou E, Bricca L, Menni AE, Golfakis P, Kotzampassi K.	Eur J Gastroenterol Hepatol	10.1097/meg.0000000000003062	2025
	Probiotics reduce the severity of DSS-induced colitis in aged mice by enhancing intestinal barrier function and modulating gut microbiota.	Liu AL, Lv H, Wang HY, Yang H, Li Y, Jia YF, Qian JM.	Geroscience	10.1007/s11357-025-01900-6	2025
	Xique-xique fruits (Pilosocereus gounellei) modulate the gut microbiota: an in vitro study by the simulator of human microbial ecosystem (SHIME®).	de Araujo FF, de Paulo Farias D, Huyan Z, Ranpatabendi T, Villasante J, Pastore GM, Sawaya ACHF, Fogliano V.	Food Chem	10.1016/j.foodchem.2025.146411	2025
	Efficacy and safety of N-acetylcysteine vs. probiotics in in-vivo biofilm prevention on ureteral stents: a prospective randomized controlled pilot in vivo study.	Singh I, Agrawal H, Maurya S, Tanwar H, Gupta S, Singh NP.	Int Urol Nephrol	10.1007/s11255-025-04713-w	2025
	Clostridium butyricum ameliorates post-gastrectomy insulin resistance by regulating the mTORC1 signaling pathway through the gut-liver axis.	He Z, Xiong H, Cai Y, Chen W, Shi M, Liu L, Wu K, Deng X, Deng X, Chen T.	Microbiol Res	10.1016/j.micres.2025.128154	2025
	Clostridium Butyricum miyairi bacteriocin treatment for Clostridioides difficile infections with clinical isolates: Insights from in vitro, ex vivo, and mouse model studies.	Lee CC, Tu YC, Wu HT, Ko WC, Liu HC, Tsai PJ, Chang HN, Huang IH, Hung YP.	J Glob Antimicrob Resist	10.1016/j.jgar.2025.03.007	2025
	Recent progress of Clostridium butyricum in fish culture: Maintenance of intestinal homeostasis, improvement of disease resistance, activation of immune signaling pathways, and positive effects on fish	Cai K, Chen J, Zhang Z, Ye Y, Sang S, Luo X, Wang Y, Shan K, Ou C, Jia Ll.	Aquaculture		2025
	Analysis of long Non-Coding RNA and mRNA expression in Clostridium butyricum-Induced apoptosis in SW480 colon cancer cells.	Yang X, Wei L.	Gene	10.1016/j.gene.2024.149208	2025
	Synbiotic Supplementation Mitigates Antibiotic-Associated Diarrhea by Enhancing Gut Microbiota Composition and Intestinal Barrier Function in a Canine Model.	Shen H, Zhao Y, Zhang S, Xu J, Tong J, Yao H, Zhang H.	Probiotics Antimicrob Proteins	10.1007/s12602-025-10584-5	2025
Proteome	A rapid genome-proteome approach to identify rate-limiting steps in the butyrate production pathway in probiotic Clostridium butyricum, CBM588.	Wood L, Omorotionmwan BB, Blanchard AM, Dowle A, Tooth D, Bailey TS, Griffin R.	Anaerobe	10.1016/j.anaerobe.2025.102940	2025
	Preventive effect of Clostridium butyricum MIYAIRI against pouchitis in children with ulcerative colitis.	Koike Y, Higashi K, Sato Y, Yamashita S, Nagano Y, Shimura T, Kitajima T, Matsushita K, Okugawa Y, Okita Y, Inoue M, Uchida K, Toiyama Y.	Surg Today	10.1007/s00595-024-02984-x	2025
	Antibodies against Clostridium butyricum in the children of mothers at risk for gestational diabetes.	Peterson C, Tagoma A, Alnek K, Barenson A, Vorobjova T, Talja I, Janson H, Kirss A, Koljalg S, Sinkkonen A, Roslund MI, Uibo R, HEDIMED Investigator Group, HEDIMED Investigator group.	Immunol Med	10.1080/25785826.2025.2504021	2025
	Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg.	Zhao J, Wu L, Zhang R, Yuan M, Huang J, Jia X, Mao X.	Immunobiology	10.1016/j.imbio.2024.152857	2025
Pathogenicity	Orally-administrable supramolecular probiotic capsules enable cooperative colon-targeted inflammation inhibition for ameliorating ulcerative colitis.	Wang T, Chen J, Shu C, Shen X, Fu Y, Li M, Luo Z.	Acta Biomater	10.1016/j.actbio.2025.01.049	2025
	Management of symptomatic uncomplicated diverticular disease (SUDD) of the colon with Clostridium butyricum CBM588 versus rifaximin: a retrospective cross-sectional study.	Urgesi R, Pagnini C, De Angelis F, Khan A, Pallotta L, Fanello G, Antypas P, Di Paolo MC, Villotti G, Bertuccioli A, Sisti D, Di Pierro F, Zerbinati N, Graziani MG.	Int J Colorectal Dis	10.1007/s00384-025-05005-6	2025
Biotechnology	Multiplexed food-borne pathogen detection using an argonaute-mediated digital sensor based on a magnetic-bead-assisted imaging transcoding system.	Wang Z, Cheng X, Ma A, Jiang F, Chen Y.	Nat Food	10.1038/s43016-024-01082-y	2025
	Multiplexed Pathogenic Bacteria Detection via a Two-Dimensional Encoded Fluorescent Microsphere System.	Wang M, Li L, Wei L, Han Y, Chen Y.	Nano Lett	10.1021/acs.nanolett.4c05471	2025
	Enhancing the Immunogenicity of Nivolumab plus Ipilimumab with Live Bacterial Supplementation in Metastatic Renal Cell Carcinoma.	Zarrabi KK, Vaishampayan U, Barata PC.	Eur Urol Focus	10.1016/j.euf.2025.01.003	2024
	Innovative strategies for the rapid restoration of intestinal function in patients undergoing abdominal surgery: use of probiotics. Pilot study of 15 patients.	Radice E, Potapov O, Shabat G, Martello E, Meineri G, Risso P, DI Pierro F, Olandese F.	Minerva Gastroenterol (Torino)	10.23736/s2724-5985.24.03701-x	2025
	Effects of Clostridium butyricum and inulin supplementation on intestinal microbial composition in high-fat diet fed mice.	Liu J, Zhang S, Weng H.	Food Funct	10.1039/d4fo02963a	2024
Pathogenicity	Micropore Resistance Counting Platform for Multiplexed and Ultrasensitive Detection of Mycotoxins and Biomarkers.	Li L, Wang M, Dong Y, Yu D, Chen Y.	ACS Nano	10.1021/acsnano.4c12394	2025
	Hypoglycemic effect of C. butyricum-pMTL007-GLP-1 engineered probiotics on type 2 diabetes mellitus.	Zhou D, Li S, Hu G, Wang Y, Qi Z, Xu X, Wei J, Liu Q, Chen T.	Gut Microbes	10.1080/19490976.2024.2447814	2025
	Gut Microbiota in Immuno-Oncology: A Practical Guide for Medical Oncologists With a Focus on Antibiotics Stewardship.	Elkrief A, Routy B, Derosa L, Bolte L, Wargo JA, McQuade JL, Zitvogel L.	Am Soc Clin Oncol Educ Book	10.1200/edbk-25-472902	2025
	New insight into Clostridium butyricum-ferroferric oxide hybrid system in exogenous carbon dioxide-assisted anaerobic fermentation for acetate and butyrate production.	Li P, Lin Z, Li C, Luo Q, Weng S, Zeng Y, Lan Z, Wang W, Zhang Y.	Bioresour Technol	10.1016/j.biortech.2024.131576	2024
	Vine shoots pre-treatment strategies for improved hydrogen production and metabolites redistribution in Clostridium butyricum	Silva Rabelo CAB, Vidal AM, Casanova-Gonzalez R, Romero-Garcia JM, Varesche MBA, Romero I, Castro E.	Industrial crops and products.		2024
	Health-promoting effects of Clostridium butyricum GKB7 on the gastrointestinal tract in murine models.	Tsai YS, Chen CC, Lee LY, Lin SW, Chen YL, Chen CC.	Biochem Biophys Rep	10.1016/j.bbrep.2025.102145	2025
Pathogenicity	Liujunzi Decoction Regulated Intestinal Flora Homeostasis to Relieve Lung-Gut Axis Inflammation in Asthma Flora Disorder Mice: Possibly Related to GATA3/ILC2.	Xu WT, Wang Q, Wu XY, Huang JH, Wang J.	Chin J Integr Med	10.1007/s11655-025-3929-3	2025
Genetics	Probiotics-related Clostridium butyricum bacteraemia after COVID-19, confirmed by whole-genome sequencing.	Kawamoto Y, Suzuki M, Iwata M, Uehara Y.	BMJ Case Rep	10.1136/bcr-2024-261578	2024
	Western diet-based NutriCol medium: A high-pectin, low-inulin culture medium promoted gut microbiota stability and diversity in PolyFermS and M-ARCOL continuous in vitro models	Esmail GA, Uriot O, Mottawea W, Denis S, Sultan S, Njoku EN, Chiba M, Tosh S, Blanquet-Diot S, Hammami R.	Food Research International.		2025
	Dietary Clostridium butyricum metabolites mitigated the disturbances in growth, immune response and gut health status of Ctenopharyngodon idella subjected to high cottonseed and rapeseed meal diet.	Wang S, Cai M, Wang Y, Zhong L, Hu Y, Fu G.	Fish Shellfish Immunol	10.1016/j.fsi.2024.109934	2024
	Clinical Applications of Microbiome in Renal Cell Carcinoma.	Elyas S, Barata P, Vaishampayan U.	Eur Urol Focus	10.1016/j.euf.2024.12.006	2024
Phylogeny	Investigating transmission patterns among preterm neonates during an outbreak of necrotizing enterocolitis related to Clostridium butyricum using whole-genome sequencing.	Sartor C, Mikrat Y, Grandvuillemin I, Caputo A, Ligi I, Chanteloup A, Penant G, Jardot P, Romain F, Levasseur A, Boubred F, La Scola B, Cassir N.	J Hosp Infect	10.1016/j.jhin.2024.07.009	2024
	Exploring sustainable biohydrogen production from dried food waste: Optimization strategies and environmental implications.	Pandey AK, Park KD, Morya R, Joo HH, Kim SH.	J Environ Manage	10.1016/j.jenvman.2025.124195	2025
	Harnessing the Engineered Probiotic-Nanosystem to Remodulate Tumor Extracellular Matrix and Regulate Tumor-Colonizing Bacteria for Improving Pancreatic Cancer Chemo-Immunotherapy.	Yao WQ, Song WF, Deng XC, Lin YT, Meng R, Wang JW, Chen WH, Zhang XZ.	Small	10.1002/smll.202406837	2025
	Redesigned Guide DNA Enhanced Clostridium butyricum Argonaute Activity for Amplification-Free and Multiplexed Detection of Pathogens.	He Y, Wang S, Wen J, Feng N, Ma R, Zhang H, Chen G, Chu X, Chen Y.	Nano Lett	10.1021/acs.nanolett.4c02723	2024
	Insight into furfural-tolerant and hydrogen-producing microbial consortia: Mechanism of furfural tolerance and hydrogen production.	Luo LL, Zhu MJ.	Bioresour Technol	10.1016/j.biortech.2024.131141	2024
	Clostridium butyricum upregulates GPR109A/AMPK/PGC-1alpha and ameliorates acute pancreatitis-associated intestinal barrier injury in mice.	Deng G, Wen B, Jia L, Liu J, Yan Q.	Arch Microbiol	10.1007/s00203-024-04001-8	2024
	Supplemental illite or in combination with probiotics improves performance and intestinal health in broiler chickens challenged with Salmonella typhimurium.	Kim H, Lee J, Kim S, Kim B, Chang S, Song D, Park S, Jeon K, Cho J.	J Anim Sci Technol	10.5187/jast.2024.e71	2025
	Hyaluronic Acid-Nanocoated Bacteria Generate an Anti-Inflammatory Tissue-Repair Effect in Impaired Gut and Extraintestinal Organs.	Deng B, Lin S, Wang Y, Zhang M, Shen Y, Zhou P, Shen A, Wang L, Ding F, Liu J.	Adv Mater	10.1002/adma.202412783	2025
	Clostridium butyricum Supplementation Reduces Diarrhea in Preweaning Calves by Modulating Fecal Short-Chain Fatty Acids and Gut Microbiota.	Gao P, Pang S, Wang Q, Tang Y, Li Q, Zhang W, Nie C, Ma X, Niu J.	Microorganisms	10.3390/microorganisms13091993	2025
	Survival and Morphological Changes of Clostridium butyricum Spores Co-Exposed to Antibiotics and Simulated Gastrointestinal Fluids: Implications for Antibiotic Stewardship.	Yang YM, Zhang MY, Wu YY, Zhang L, Zhang YX.	Microorganisms	10.3390/microorganisms13061347	2025
Genetics	Pangenome analyses of Clostridium butyricum provide insights into its genetic characteristics and industrial application.	Yang Y, Shao Y, Pei C, Liu Y, Zhang M, Zhu X, Li J, Feng L, Li G, Li K, Liang Y, Li Y.	Genomics	10.1016/j.ygeno.2024.110855	2024
Metabolism	Isolation and Identification of Human Gut Bacteria Capable of Converting Curcumin to Its Hydrogenated Metabolites.	Luo M, Wong S, Thanuphol P, Du H, Han Y, Lin M, Guo X, Bechtel TD, Gibbons JG, Xiao H.	J Agric Food Chem	10.1021/acs.jafc.4c03828	2024
	Clostridium butyricum GKB7 increase Physical Performance and Improve Biochemistry Profile on Mice with Inherently Low Aerobic Capacity.	Lee MC, Chen CY, Hsu YJ, Lin SW, Tsai YS, Chen YL, Chen CC, Huang CC.	Int J Med Sci	10.7150/ijms.118805	2025
	Synergistic effect of inulin hydrogels on multi-strain probiotics for prevention of ionizing radiation-induced injury.	Du S, Sun R, Wang M, Fang Y, Wu Y, Yuan B, Jin Y.	Int J Biol Macromol	10.1016/j.ijbiomac.2024.138497	2025
	An Amplification-Free Digital Assay Based on Primer Exchange Reaction-Mediated Botryoidal-Like Fluorescent Polystyrene Dots to Detect Multiple Pathogenic Bacteria.	Wang Z, Ma A, Chen Y.	ACS Nano	10.1021/acsnano.4c09069	2024
Pathogenicity	Live and Dead Clostridium butyricum GKB7 Diminish Osteoarthritis Pain and Progression in Preclinical Animal Model.	Chen LC, Lin YY, Tsai YS, Chen CC, Chang TC, Chen HT, Hsu CJ, Tang CH.	Environ Toxicol	10.1002/tox.24367	2024
	Dietary supplementation of Clostridium butyricum and rumen protected fat alters immune responses, rumen fermentation, and bacterial communities of goats	Jiao P, Wang Z, Zhang X, Lu X, Sun Q, Zhao H, Xin H, Yang W, Lv X, Xie X, Hou Y.	Anim Feed Sci Technol		2024
Cultivation	Western diet-based NutriCol medium: A high-pectin, low-inulin culture medium promoted gut microbiota stability and diversity in PolyFermS and M-ARCOL continuous in vitro models.	Esmail GA, Uriot O, Mottawea W, Denis S, Sultan S, Njoku EN, Chiba M, Tosh S, Blanquet-Diot S, Hammami R.	Food Res Int	10.1016/j.foodres.2025.115993	2025
	The Role of Short-Chain Fatty Acids, Particularly Butyrate, in Oncological Immunotherapy with Checkpoint Inhibitors: The Effectiveness of Complementary Treatment with Clostridium butyricum 588.	Cazzaniga M, Cardinali M, Di Pierro F, Zonzini GB, Palazzi CM, Gregoretti A, Zerbinati N, Guasti L, Matera MR, Cavecchia I, Bertuccioli A.	Microorganisms	10.3390/microorganisms12061235	2024
Phylogeny	Full-length 16S rRNA gene amplicon analysis of gut microbiota in pigs fed with different diets in growing and finishing stages.	Wang HS, Shih SY, Huang YL, Chang CC, Tsai H.	Anim Biotechnol	10.1080/10495398.2024.2414299	2024
Phylogeny	Exploring the effect of Clostridium butyricum on lung injury associated with acute pancreatitis in mice by combined 16S rRNA and metabolomics analysis.	Liu J, Wen B, Huang Y, Deng G, Yan Q, Jia L.	Anaerobe	10.1016/j.anaerobe.2024.102854	2024
	Oxymatrine and Gut Microbiota Modulation: A Potential Therapeutic Strategy for Bone Cancer Pain Management.	Liu Z, Chen H, Ning X, Li J, Pan L.	J Pain	10.1016/j.jpain.2024.104588	2024
	Oral Clostridium butyricum on mice endometritis through uterine microbiome and metabolic alternations.	Hagihara M, Ariyoshi T, Eguchi S, Oka K, Takahashi M, Kato H, Shibata Y, Umemura T, Mori T, Miyazaki N, Hirai J, Asai N, Mori N, Mikamo H.	Front Microbiol	10.3389/fmicb.2024.1351899	2024
	Effect of acidification pretreatment on two-phase anaerobic digestion of acidified food waste.	Wang X, Ming X, Chen M, Han X, Li X, Zhang D.	Waste Manag	10.1016/j.wasman.2024.09.022	2024
	Comprehensive field investigation of a large botulism outbreak, Saudi Arabia, 2024.	Zuayr SNA, Kamel SA, Almutairi AS, AlAsseri YA, Alfaifi M, Alyahya B, Deeb MA, Albogami HA, Alrougi HM, Saqah RM, Alahmad AM, Almutairi AEH, Abd-Ellatif EE.	J Infect Public Health	10.1016/j.jiph.2025.102702	2025
	Clostridium butyricum CGMCC 0313.1 improves clinical outcomes of metabolic syndrome in schizophrenic patients.	Song L, Zhang Z, Zheng W, Wang Y, Zhang Y.	Am J Transl Res	10.62347/dnil9369	2025
Transcriptome	Bacillus coagulans and Clostridium butyricum synergistically alleviate depression in a chronic unpredictable mild stress mouse model through altering gut microbiota and prefrontal cortex gene expression.	Xu J, Zhou L, Chen Z, Wang Y, Xu F, Kuang Q, Zhang Y, Zheng H.	Front Pharmacol	10.3389/fphar.2024.1393874	2024
	The anti-obesity effects of Clostridium butyricum B-3 and its impact on gut microbiota.	Meng Y, Bai L-J, Meng J, Ding C-H, Xi J.	Appl Environ Microbiol	10.1128/aem.01152-25	2025
	Bound Polyphenols of Oat Bran Released by Gut Microbiota Mitigate High Fat Diet-Induced Oxidative Stress and Strengthen the Gut Barrier via the Colonic ROS/Akt/Nrf2 Pathway.	Zhang Y, Bai B, Huang K, Li S, Cao H, Guan X.	J Agric Food Chem	10.1021/acs.jafc.4c01666	2024
	Physiological and biochemical characteristics of the carbon ion beam irradiation-generated mutant strain Clostridium butyricum FZM 240 in vitro and in vivo.	Wang YJ, Zhou X, Zhang MM, Liu MH, Ding N, Wu QF, Lei CR, Dong ZY, Ren JL, Zhao JR, Jia CL, Liu J, Zhou B, Lu D.	Enzyme Microb Technol	10.1016/j.enzmictec.2024.110447	2024
Pathogenicity	The Potential of Clostridium butyricum to Preserve Gut Health, and to Mitigate Non-AIDS Comorbidities in People Living with HIV.	Yang Q, Zaongo SD, Zhu L, Yan J, Yang J, Ouyang J.	Probiotics Antimicrob Proteins	10.1007/s12602-024-10227-1	2024
	Evaluation of individual and combined effect of lactic acid-consuming bacteria on mesophilic hydrogen production from lactic acid effluent from food waste treatment.	Villanueva-Galindo E, Perez-Rangel M, Moreno-Andrade I.	Bioresour Technol	10.1016/j.biortech.2024.131224	2024
	Preliminary Multi-Omics Insights into Green Alternatives to Antibiotics: Effects of Pulsatilla chinensis, Acer truncatum, and Clostridium butyricum on Gut Health and Metabolic Regulation in Chickens.	Sun L, Wang Z, Qin S, Liang C, Zhao A, He K.	Animals (Basel)	10.3390/ani15091262	2025
	The antioxidant strain Lactiplantibacillus plantarum AS21 and Clostridium butyricum ameliorate DSS-induced colitis in mice by remodeling the assembly of intestinal microbiota and improving gut functions.	Li W, Zhang Y, Chen M, Guo X, Ding Z.	Food Funct	10.1039/d3fo05337g	2024
Pathogenicity	Novel mechanism of Clostridium butyricum alleviated coprophagy prevention-induced intestinal inflammation in rabbit.	Li Z, He H, Chen M, Ni M, Guo C, Wan Z, Zhou J, Wang Z, Wang Y, Cai H, Li M, Sun H, Xu H.	Int Immunopharmacol	10.1016/j.intimp.2024.111773	2024
	Kinetics-based development of two-stage continuous fermentation of 1,3-propanediol from crude glycerol by Clostridium butyricum.	Wang XL, Sun YQ, Pan DT, Xiu ZL.	Biotechnol Biofuels Bioprod	10.1186/s13068-024-02486-5	2024
	Butyrate modulates gut microbiota and anti-inflammatory response in attenuating cisplatin-induced kidney injury.	Chen WJ, Chen YT, Ko JL, Chen JY, Zheng JY, Liao JW, Ou CC.	Biomed Pharmacother	10.1016/j.biopha.2024.117689	2024
	Supplementation of Clostridium butyricum LV1 lyophilised powder to cottonseed protein concentrate basal diets improves growth, intestinal microbiota, and immunity of Litopenaeus vannamei	Wang Q, Fan D, Hu Y, Liu H, Tan B, Xie S.	Aquaculture		2024
	Enhancing and monitoring spore production in Clostridium butyricum using pH-based regulation strategy and a robust soft sensor based on back-propagation neural networks.	Xu F, Zhang W, Wang Y, Tian X, Chu J.	Biotechnol Bioeng	10.1002/bit.28597	2024
	A machine vision-assisted Argonaute-mediated fluorescence biosensor for the detection of viable Salmonella in food without convoluted DNA extraction and amplification procedures.	Zhao J, Han M, Ma A, Jiang F, Chen R, Dong Y, Wang X, Ruan S, Chen Y.	J Hazard Mater	10.1016/j.jhazmat.2024.133648	2024
	Excessive Existence of Positively Charged Amino Acids Caused Off-Target Recognition in the Seed Region of Clostridium butyricum Argonaute.	Ma W, Lyu W, Zhu L.	Int J Mol Sci	10.3390/ijms26104738	2025
	Probiotic Clostridium butyricum ameliorates cognitive impairment in obesity via the microbiota-gut-brain axis.	Zheng M, Ye H, Yang X, Shen L, Dang X, Liu X, Gong Y, Wu Q, Wang L, Ge X, Fang X, Hou B, Zhang P, Tang R, Zheng K, Huang XF, Yu Y.	Brain Behav Immun	10.1016/j.bbi.2023.11.016	2024
	Clostridium butyricum Alleviates DEHP Plasticizer-Induced Learning and Memory Impairment in Mice via Gut-Brain Axis.	Wang J, Qiu F, Zhang Z, Liu Y, Zhou Q, Dai S, Xiang S, Wei C.	J Agric Food Chem	10.1021/acs.jafc.3c03533	2023
	Influence of Dietary Probiotic and Alpha-Monolaurin on Performance, Egg Quality, Blood Constituents, and Egg Fatty Acids' Profile in Laying Hens.	Saleh AA, Galosi L, Metwally M, Ragab M, Hamza M, Shukry M, Khairy M, Alzawqari MH, Azzam MM, Alagawany M.	Probiotics Antimicrob Proteins	10.1007/s12602-024-10260-0	2024
Genetics	Clostridium butyricum and carbohydrate active enzymes contribute to the reduced fat deposition in pigs.	Ma L, Tao S, Song T, Lyu W, Li Y, Wang W, Shen Q, Ni Y, Zhu J, Zhao J, Yang H, Xiao Y.	Imeta	10.1002/imt2.160	2024
	Dietary inclusion of Clostridium butyricum cultures alleviated impacts of high-carbohydrate diets in largemouth bass (Micropterus salmoides).	Tao J, Gong Y, Chen S, Li W, Xie R, Zhang H, Chen N, Huang X, Li S.	Br J Nutr	10.1017/s0007114523002842	2024
Genetics	Dynamic flux balance analysis of 1,3-propanediol production by clostridium butyricum fermentation.	Pan DT, Wang P, Wang XL, Sun YQ, Xiu ZL.	Biotechnol Prog	10.1002/btpr.3411	2024
Pathogenicity	Clostridium butyricum Ameliorates Atherosclerosis by Regulating Host Linoleic Acid Metabolism.	Yin C, Fan P, Mou X, Zhao W.	Microorganisms	10.3390/microorganisms13061220	2025
	The Probiotic Strain Clostridium butyricum TO-A Produces Butyrate by Utilizing Lactate and Acetate.	Honda S, Eguchi H, Okino Y, Wang DS.	Int J Mol Sci	10.3390/ijms26072951	2025
	Probiotic-related Clostridium butyricum bacteremia: a case report and literature review.	Ishikawa K, Hasegawa R, Shibutani K, Mikami Y, Kawai F, Matsuo T, Uehara Y, Mori N.	Anaerobe	10.1016/j.anaerobe.2023.102770	2023
	Advances in understanding the role of gut microbiota in fat deposition and lipid metabolism.	Zhong Y, Lei Y, Jiang S, Chen D, Wang X, Wang K, Liao T, Liao R, Gan M, Niu L, Zhao Y, Chen L, Zhou X, Wang Y, Zhu L, Shen L.	J Anim Sci Biotechnol	10.1186/s40104-025-01284-9	2025
	Sensing of DNA modifications by pAgo proteins in vitro.	Beskrovnaia M, Agapov A, Makasheva K, Zharkov DO, Esyunina D, Kulbachinskiy A.	Biochimie	10.1016/j.biochi.2023.12.006	2024
	The effectiveness of probiotics as an adjunct therapy in patients under mechanical ventilation: an umbrella systematic review and meta-analysis.	Anvarifard P, Anbari M, Ghalichi F, Ghoreishi Z, Zarezadeh M.	Food Funct	10.1039/d3fo04653b	2024
	Complete genome sequence of Clostridium butyricum DKU-11, isolated from healthy infant feces.	Mo S.	Microbiol Resour Announc	10.1128/mra.00037-24	2024
	Irritable Bowel Syndrome with Diarrhea (IBS-D): Effects of Clostridium butyricum CBM588 Probiotic on Gastrointestinal Symptoms, Quality of Life, and Gut Microbiota in a Prospective Real-Life Interventional Study.	Di Pierro F, Ficuccilli F, Tessieri L, Menasci F, Pasquale C, Khan A, Rabbani F, Memon NM, Cazzaniga M, Bertuccioli A, Matera M, Cavecchia I, Recchia M, Palazzi CM, Tanda ML, Zerbinati N.	Microorganisms	10.3390/microorganisms13051139	2025
	The Microbiota-gut-brain axis in vascular cognitive impairment: unraveling the mysterious link and therapeutic prospects.	Liu T, Li Y, Xiong X, Lai X, Xu X.	Front Immunol	10.3389/fimmu.2025.1648800	2025
Metabolism	Effects of Clostridium butyricum on Physiological Parameters and Gut Microbiota in Newborn Hanwoo Calves.	Kim MJ, Kim YL, Lee SH, Shin JS, Kim SK, Kim SA, Jo IG, Jo GH, Han SJ, Bae KD, Ban EJ, Park BK.	Animals (Basel)	10.3390/ani15192785	2025
	Supplemental Clostridium butyricum modulates skeletal muscle development and meat quality by shaping the gut microbiota of lambs	Dou L, Liu C, Chen X, Yang Z, Hu G, Zhang M, Sun L, Su L, Zhao L, Jin Y.	Meat Science.		2023
Pathogenicity	Clostridium Butyricum 337279 shapes the gut microbiota to attenuate metabolic disorder in diet-induced obese mice.	Zhang X, Li Z, Cao J, Sun H, Niu W.	Front Microbiol	10.3389/fmicb.2025.1580847	2025
	Hyperspectral imaging through vacuum packaging for monitoring cheese biochemical transformation caused by Clostridium metabolism	Reis MM, Dixit Y, Carr A, Tu C, Palevich F, Gupta T, Reis MG.	Food Research International.		2024
	Clostridium butyricum MIYAIRI 588 alleviates periodontal bone loss in mice with diabetes mellitus.	Zhang Y, Lu M, Zhang Y, Yuan X, Zhou M, Xu X, Zhang T, Song J.	Ann N Y Acad Sci	10.1111/nyas.15058	2023
	Effects of rumen-protected or unprotected Clostridium butyricum on growth performance, rumen fermentation, immunity and antioxidation in fattening goats.	Zhang C, Han J, Wang H.	PLoS One	10.1371/journal.pone.0330512	2025
	Effect of Clostridium butyricum on the formation of primary choledocholithiasis based on intestinal microbiome and metabolome analysis.	Li G, Yu T, Du H, Zhang L, Liu X, Hou S.	J Appl Microbiol	10.1093/jambio/lxad170	2023
Genetics	Diversity within the species Clostridium butyricum: pan-genome, phylogeny, prophage, carbohydrate utilization, and antibiotic resistance.	Pei Z, Liu Y, Yi Z, Liao J, Wang H, Zhang H, Chen W, Lu W.	J Appl Microbiol	10.1093/jambio/lxad127	2023
	The Effect of Clostridium butyricum-Derived Lipoteichoic Acid on Lipopolysaccharide-Stimulated Porcine Intestinal Epithelial Cells.	Chen Q, Ma L, Wen Y, Lyu W, Yu M, Yang H, Xiao Y.	Vet Med Sci	10.1002/vms3.70157	2025
Phylogeny	Microbiota in patients with cefuroxime resistance and anal fistula revealed by 16S ribosomal DNA.	Ling YT, Yao F, Li SJ, Cao CX, Chen ZW, Qiu M, Li BZ, Hu BW, Zhong SY, Hu GL, Li JH.	World J Gastrointest Surg	10.4240/wjgs.v17.i1.100790	2025
	Clostridium butyricum ameliorates indomethacin-induced enteropathy by promoting MUC2 secretion via suppressing the Notch pathway.	Zhu L, Luo Y, Liu Y, Sun S, Yuan J, Zhang L, Zhong W, Ma S, Yu Z, Zhou J, Chen X, Zhao J.	Front Microbiol	10.3389/fmicb.2025.1509876	2025
	Effects of probiotics in children with acute gastroenteritis: A systematic review and meta-analysis focusing on probiotics utilized in Japan.	Higuchi T, Furuichi M, Maeda N, Tsugawa T, Ito K.	J Infect Chemother	10.1016/j.jiac.2023.11.005	2024
	Paeonol alleviates ulcerative colitis in mice by increasing short-chain fatty acids derived from Clostridium butyricum.	Zhao M, Xie X, Xu B, Chen Y, Cai Y, Chen K, Guan X, Ni C, Luo X, Zhou L.	Phytomedicine	10.1016/j.phymed.2023.155056	2023
	A Study on the Differences in Rumen Microbiota-Liver Gluconeogenesis-Mitochondrial Interaction Between Tibetan Sheep and Hu Sheep in the Qinghai-Tibet Plateau.	Chen Q, Sha Y, Liu X, Gao M, Chen X, Yang W, Huang W, Wang J, He Y, Gao X, He Y.	Animals (Basel)	10.3390/ani15111603	2025
	Preparation of valine-curcumin conjugate and its in vitro antibacterial and antitumor activity and in vivo biological effects on American eels (Anguilla rostrata).	Ni J, Zhang Y, Zhai S, Xiong H, Ming Y, Ma Y.	Fish Shellfish Immunol	10.1016/j.fsi.2024.109615	2024
	Impact of supplementing Limosilactobacillus fermentum MN-LF23 on the eradication of Helicobacter pylori with 14-day standard quadruple therapy: a randomized, double-blind, placebo-controlled trial.	Zhao Y, Niu X, Zhang Y, Zhao L, Zhang L, He J, Zhang Q, Mao Y, Wang F, Zhao X, Wang R.	Nutr J	10.1186/s12937-025-01124-6	2025
	Tryptophan-producing bacteria to mitigate osteoporosis and intestinal dysfunction	Tian B, Wang H, Zhang Y, Lv J, Li D, Zhou C, Xu J, Ni Y, Wu B, Zhang M, Dai H, Xu F, Bai J, Wang C, Zhou X.	Bioact Mater		2025
	Clostridium butyricum and its metabolite butyrate promote ferroptosis susceptibility in pancreatic ductal adenocarcinoma.	Yang X, Zhang Z, Shen X, Xu J, Weng Y, Wang W, Xue J.	Cell Oncol (Dordr)	10.1007/s13402-023-00831-8	2023
	Clostridium butyricum, a future star in sepsis treatment.	Zhao J, Jiang L, He W, Han D, Yang X, Wu L, Zhong H.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1484371	2024
	An innovative permeable reactive bio-barrier to remediate trichloroethene-contaminated groundwater: A field study.	Lu CW, Lo KH, Wang SC, Kao CM, Chen SC.	Sci Total Environ	10.1016/j.scitotenv.2024.170885	2024
	Maximizing biohydrogen production from watermelon peels using Clostridium butyricum NE133: a statistical optimization approach with Plackett-Burman and Box-Behnken designs.	Elerakey N, Rasmey AM, Mohammed YM, Aboseidah AA, Hawary H.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02652-3	2025
	Efficacy of Clostridium butyricum Supplementation Combined with Phototherapy for Neonatal Hyperbilirubinemia: A Systematic Review and Meta-Analysis.	Kim EJ, Go HY, Sung HK.	Microorganisms	10.3390/microorganisms13071441	2025
	Anti-Inflammatory Effect of Clostridium butyricum-Derived Extracellular Vesicles in Ulcerative Colitis: Impact on Host microRNAs Expressions and Gut Microbiome Profiles.	Ma L, Lyu W, Song Y, Chen K, Lv L, Yang H, Wang W, Xiao Y.	Mol Nutr Food Res	10.1002/mnfr.202200884	2023
	Optimization of the Dark Fermentation Technique for Hydrogen Production through Supplementation with Ascorbic Acid and/or l-Cysteine by Clostridium butyricum CCDBC 11.	Pistekova H, Dusankova M, Sopik T, Klaban J, Dostalkova J, Moucka R, Sedlarik V.	J Agric Food Chem	10.1021/acs.jafc.5c03194	2025
	Clostridium butyricum: a promising approach to enhancing intestinal health in poultry	Tang X, Zeng Y, Li M.	Front Vet Sci		2025
	Application of Clostridium butyricum, Rummeliibacillus suwonensis, and Issatchenkia orientalis for Nongxiangxing baijiu fermentation: Improves the microbial communities and flavor of upper fermented grain	Guan T, Wu X, Hou R, Tian L, Huang Q, Zhao F, Liu Y, Jiao S, Xiang S, Zhang J, Li D, Luo J, Jin Z, He Z.	Food Res Int		2023
	Microbial Conversion of Glycerol Into 1,3-Propanediol by Fermentation: Review of Fundamentals and Operational Strategies.	Perez-Bernal MF, Moscoviz R, Wang X, Bernet N, Trably E.	Microb Biotechnol	10.1111/1751-7915.70265	2025
	Structure, antioxidant properties, and protective effects on DNA damage of exopolysaccharides from Clostridium butyricum.	Cai G, Geng Y, Liu Y, Yang S, Li X, Sun H, Lu J.	J Food Sci	10.1111/1750-3841.16609	2023
	Incorporation of Azadirachta indica kernel in the diet of guinea pigs: effects on digestibility and caecal health.	Djoumessi Tobou GF, Kenfack LBM, Miegoue E, Fokom DW, Kuitche HM, Kesnel ZDD, Tendonkeng F, Clerge T, Hornick JL.	Trop Anim Health Prod	10.1007/s11250-025-04476-7	2025
	Single Strain vs Multiple Strain Probiotics: The Clinician's Choice.	Kesavelu D, Yadav Krishnamurty A, A P.	Cureus	10.7759/cureus.86353	2025
	Supplemental Clostridium butyricum modulates skeletal muscle development and meat quality by shaping the gut microbiota of lambs.	Dou L, Liu C, Chen X, Yang Z, Hu G, Zhang M, Sun L, Su L, Zhao L, Jin Y.	Meat Sci	10.1016/j.meatsci.2023.109235	2023
	In vitro batch fermentation of (un)saturated homogalacturonan oligosaccharides.	Zwolschen JW, Vos AP, Ariens RMC, Schols HA.	Carbohydr Polym	10.1016/j.carbpol.2024.121789	2024
	Mesophilic Argonaute-Mediated Polydisperse Droplet Biosensor for Amplification-Free, One-Pot, and Multiplexed Nucleic Acid Detection Using Deep Learning.	Wang Z, Feng N, Zhou Y, Cheng X, Zhou C, Ma A, Wang Q, Li Y, Chen Y.	Anal Chem	10.1021/acs.analchem.3c04426	2024
	Effect of Clostridium butyricum on intestinal microbiota and resistance to Vibrio alginolyticus of Penaeus vannamei.	Wang C, Li PF, Hu DG, Wang H.	Fish Shellfish Immunol	10.1016/j.fsi.2023.108790	2023
	[Effects of Peroxisome Proliferator-Activated Receptor gamma on Modulating Angiopoietin-Like Protein 4 Synthesis in Caco-2 Cells Exposed to Clostridium butyricum].	Zhao X, Huang HS, Shi SR.	Mol Biol (Mosk)	10.31857/s0026898423030217, edn: cibngm	2023
	Probiotics and Immunostimulant modulate intestinal flora diversity in Reeves' Turtle (Mauremys reevesii) and effects of Clostridium butyricum on its spleen transcriptome.	Luo M, Feng G, Chen M, Ke H.	Fish Shellfish Immunol	10.1016/j.fsi.2023.108908	2023
	Gut health management in livestock: roles of probiotics, prebiotics, and synbiotics in growth, immunity, and microbiota modulation.	Chowdhury MR, Hassan M, Shimosato T.	Vet Res Commun	10.1007/s11259-025-10927-1	2025
	The butyrate derived from probiotic Clostridium butyricum exhibits an inhibitory effect on multiple myeloma through cell death induction.	Konishi H, Saito T, Takahashi S, Tanaka H, Okuda K, Akutsu H, Dokoshi T, Sakatani A, Takahashi K, Ando K, Kashima S, Ueno N, Moriichi K, Ogawa N, Fujiya M.	Sci Rep	10.1038/s41598-025-97038-8	2025
	Assessing the impact of probiotics on immunotherapy effectiveness and antibiotic-mediated resistance in cancer: a systematic review and meta-analysis.	Zhao S, Lu Z, Zhao F, Tang S, Zhang L, Feng C.	Front Immunol	10.3389/fimmu.2025.1538969	2025
	Therapeutic effect of Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. leaves on ischemic stroke via the microbiota-gut-brain axis.	Wang R, Sun Y, Wang M, Li H, Liu S, Liu Z.	Phytother Res	10.1002/ptr.7947	2023
	Application of Clostridium butyricum, Rummeliibacillus suwonensis, and Issatchenkia orientalis for Nongxiangxing baijiu fermentation: Improves the microbial communities and flavor of upper fermented grain.	Guan T, Wu X, Hou R, Tian L, Huang Q, Zhao F, Liu Y, Jiao S, Xiang S, Zhang J, Li D, Luo J, Jin Z, He Z.	Food Res Int	10.1016/j.foodres.2023.112885	2023
	High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study.	Castaneda-Monsalve V, Frohlich LF, Haange SB, Homsi MN, Rolle-Kampczyk U, Fu Q, von Bergen M, Jehmlich N.	Front Microbiol	10.3389/fmicb.2024.1349367	2024
Pathogenicity	Clostridium butyricum enhances cognitive function in APP/PS1 mice by modulating neuropathology and regulating acetic acid levels in the gut microbiota.	Shiqing Y, Xinjie L, Xiaotong Z, Jiayan C, Jiahai L, Xiaodong C, Yongliang L, Xiang L.	Microbiol Spectr	10.1128/spectrum.00178-25	2025
	Targeted probiotic therapy in irritable bowel syndrome: a clinical evaluation on Clostridium butyricum CBM588 and Bifidobacterium longum W11	Bertuccioli A, Sisti D, Lazzerini N, Palazzi C, Zonzini G, Ragazzini M, Belli A.	Front Med (Lausanne)		2025
Genetics	The isolation, identification, whole-genome sequencing of Clostridium butyricum LV1 and its effects on growth performance, immune response, and disease-resistance of Litopenaeus vannamei.	Wang Q, Li W, Liu H, Tan B, Dong X, Chi S, Yang Q, Zhang S, Fan D, Hu Y.	Microbiol Res	10.1016/j.micres.2023.127384	2023
	Insight into three water additives: Revealing the protective effects on survival and stress response under cold stress for Pacific white shrimp Litopenaeus vannamei.	Fan L, Liao G, Wang Z, Liu H, Cheng K, Hu J, Yang Y, Zhou Z.	Fish Shellfish Immunol	10.1016/j.fsi.2023.108845	2023
	Effect of probiotics on immune cells in young Japanese Black calves responding to vaccination against bacterial respiratory diseases.	Takeda S, Ohtsuka H, Kosenda K.	J Vet Res	10.2478/jvetres-2025-0013	2025
	The relationship between Clostridium butyricum and colorectal cancer.	Liu H, Xu X, Liang J, Wang J, Li Y.	J Cancer Res Ther	10.4103/jcrt.jcrt_1565_21	2022
	Evaluation of Streptococcus faecalis, Clostridium butyricum, Bacillus mesentericus, Lactobacillus sporogenes, Saccharomyces Boulardi multistrain probiotic formulation in acute gastroenteritis: a real-world observational study (MAESTRO).	Patel BD, Kulkarni G, Chowdhuri S, Arya A, John KM, Doshi ASP, Nair R, Korukonda K.	BMC Nutr	10.1186/s40795-025-01127-w	2025
	Effects of Dietary Clostridium butyricum on Growth and Intestinal Mucosal Barrier Functions of Juvenile Channel Catfish (Ictalurus punctatus).	Guo Z, Qian Y, Peng X, Qin C, Ren H, Du J, Huang C, Pan M, Ou W.	Microorganisms	10.3390/microorganisms13051061	2025
	Intranasal administration of Clostridium butyricum and its derived extracellular vesicles alleviate LPS-induced acute lung injury.	Liu L, Zheng C, Xu Z, Wang Z, Zhong Y, He Z, Zhang W, Zhang Y.	Microbiol Spectr	10.1128/spectrum.02108-24	2024
	Temporal changes in computed tomography findings of a persimmon bezoar: A case report.	Iwamuro M, Yoshikawa T, Kamio T, Hirata S, Matsueda K, Kametaka D, Otsuka M.	World J Clin Cases	10.12998/wjcc.v13.i18.103426	2025
	Influence of Gut Microbiota-Derived Butyrate on Intestinal Uric Acid Excretion and Hyperuricemia Regulation by Cichorium intybus L.	Yang Y, Wang Y, Huang J, Xu Y, Yin X, Lin Z, Zhang B.	Int J Mol Sci	10.3390/ijms26136413	2025
Pathogenicity	Orm2 Deficiency Aggravates High-Fat Diet-Induced Obesity through Gut Microbial Dysbiosis and Intestinal Inflammation.	Li L, Chen J, Sun H, Niu Q, Zhao Y, Yang X, Sun Q.	Mol Nutr Food Res	10.1002/mnfr.202300236	2024
	The bidirectional regulatory effects of bacteria on blood vessels in the tumor microenvironment.	Peng W, Huang X, Pu Y, Zhang Y, Luo Y, Feng M, Li X.	Discov Oncol	10.1007/s12672-025-03874-5	2025
	Effects of fishmeal substitution by alpha-galactosidase hydrolytic soybean meal (EhSBM) on growth, antioxidant capacity, inflammatory responses and intestinal health of turbot juveniles (Scophthalmus maximus L.)	Dan Z, Zhang W, Zheng J, Gong Y, Mai K, Ai Q.	Aquaculture		2024
	Application of nanoparticles to increase biological hydrogen production: the difference in metabolic pathways in batch and continuous reactors.	Moura AGL, Rabelo CABS, Silva EL, Varesche MBA.	Environ Technol	10.1080/09593330.2023.2208274	2024
	Prevention of Recurrent Spontaneous Preterm Delivery Using Probiotics (Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis; PPP Trial): Protocol for a Prospective, Single-Arm, Nonblinded, Multicenter Trial.	Yoneda S, Kobayashi T, Kikuchi K, Iwamoto S, Teramoto T, Chujo D, Otsuki K, Nakai A, Saito S.	JMIR Res Protoc	10.2196/59928	2024
	Mesophilic Argonaute-Based Single Polystyrene Sphere Aptamer Fluorescence Platform for the Multiplexed and Ultrasensitive Detection of Non-Nucleic Acid Targets.	Lu Y, Wen J, Wang C, Wang M, Jiang F, Miao L, Xu M, Li Y, Chen X, Chen Y.	Small	10.1002/smll.202308424	2024
	Performance and mechanism of different pretreatment methods for inoculated sludge in biohydrogen production.	Cheng WX, Wang LL, Xu Y, Li SJ, Wang Q, Chen RP, Yu L.	Bioresour Technol	10.1016/j.biortech.2023.129234	2023
Pathogenicity	Clostridium butyricum alleviates weaned stress of piglets by improving intestinal immune function and gut microbiota.	Wu J, Wang J, Lin Z, Liu C, Zhang Y, Zhang S, Zhou M, Zhao J, Liu H, Ma X.	Food Chem	10.1016/j.foodchem.2022.135014	2023
Genetics	Butyrate Producers in Very Low Birth Weight Infants with Neither Culture-Proven Sepsis nor Necrotizing Enterocolitis.	Thatrimontrichai A, Praditaukrit M, Maneenil G, Dissaneevate S, Singkhamanan K, Surachat K.	Nutrients	10.3390/nu17081329	2025
	Fecal microbiota changes in people with cystic fibrosis after 6 months of elexacaftor/tezacaftor/ivacaftor: Findings from the promise study.	Duong JT, Hayden HS, Verster AJ, Pope CE, Miller C, Kelsi Penewit, Salipante SJ, Rowe SM, Solomon GM, Nichols D, Kelly A, Schwarzenberg SJ, Freedman SD, Hoffman LR.	J Cyst Fibros	10.1016/j.jcf.2025.05.006	2025
	Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder.	Liu S, Xi H, Xue X, Sun X, Huang H, Fu D, Mi Y, He Y, Yang P, Tang Y, Zheng P.	Cell Biosci	10.1186/s13578-024-01278-6	2024
	Correlation of hindgut microbiome and fermentation properties with a history of gas and/or impaction colic in Japanese draft horses.	Yano R, Moriyama T, Arai H, Scheftgen AJ, Suen G, Nishida T, Handa M, Fukuma N.	J Equine Sci	10.1294/jes.36.93	2025
	Dietary Clostridium butyricum and 25-Hydroxyvitamin D₃ modulate bone metabolism of broilers through the gut-brain axis.	Cao G, Yu Y, Wang H, Yang H, Tao F, Yang S, Liu J, Li Z, Yang C.	Poult Sci	10.1016/j.psj.2024.103966	2024
	Restoration of gut dysbiosis through Clostridium butyricum and magnesium possibly balance blood glucose levels: an experimental study.	Tayyib HMU, Ali A, Jabeen S, Habib-Ur-Rehman, Kamran H, Bajaber MA, Usman M, Zhang X.	BMC Microbiol	10.1186/s12866-024-03218-3	2024
	Metagenomic analysis of rats with diarrhea treated with mixed probiotics: response to consecutive and alternate-hour supplementation.	Wang A, Cui X, Shi C.	Transl Pediatr	10.21037/tp-24-129	2024
Phylogeny	Feeding Broiler Chicks with Bacillus subtilis, Clostridium butyricum, and Enterococcus faecalis Mixture Improves Growth Performance and Regulates Cecal Microbiota.	Dang X, Zou Q, Xu Y, Cui Y, Li X, Xiao Y, Wang T, Li D.	Probiotics Antimicrob Proteins	10.1007/s12602-022-10029-3	2024
	Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway.	Li X, Hua D, Wu D, Hong W, Kang Y, Tang L, Yang Q, Wang X, Li B, Li R, Chen Z, Cui G.	Cancer Med	10.1002/cam4.70987	2025
	Maternal Clostridium butyricum supplementation during late gestation and lactation enhances gut bacterial communities, milk quality, and reduces piglet diarrhea.	Nuntapaitoon M, Chatthanathon P, Palasuk M, Wilantho A, Ruampatana J, Tongsima S, Settachaimongkon S, Somboonna N.	Comput Struct Biotechnol J	10.1016/j.csbj.2025.06.040	2025
	Comparison of safety, efficacy and serum immune indexes of Clostridium butyricum Enterococcus triple viable vs Bifidobacterium triple viable in the treatment of bronchial asthma in children.	Zhang C, Wu QB.	Pak J Pharm Sci		2022
	Cross-feeding-based rational design of a probiotic combination of Bacterides xylanisolvens and Clostridium butyricum therapy for metabolic diseases.	Qiao S, Wang T, Sun J, Han J, Dai H, Du M, Yang L, Guo CJ, Liu C, Liu SJ, Liu H.	Gut Microbes	10.1080/19490976.2025.2489765	2025
Pathogenicity	Improvement of chronic GVHD after oral treatment with Clostridium butyricum (Miya BM).	Kaya H, Okumura H, Ishizawa S.	Anaerobe	10.1016/j.anaerobe.2022.102612	2022
	Protease or Clostridium butyricum addition to a low-protein diet improves broiler growth performance.	Wang T, Ling H, Zhang W, Zhou Y, Li Y, Hu Y, Peng N, Zhao S.	Appl Microbiol Biotechnol	10.1007/s00253-022-12264-8	2022
	Effect of Clostridium butyricum on High-Fat Diet-Induced Intestinal Inflammation and Production of Short-Chain Fatty Acids.	Choi Y, Choi SI, Kim N, Nam RH, Jang JY, Na HY, Shin CM, Lee DH, Min H, Kim YR, Seok YJ.	Dig Dis Sci	10.1007/s10620-023-07835-2	2023
	Effects of a novel synbiotics-enzyme complex as a replacement for antibiotics on growth performance, slaughter and meat characteristics, immune organ index, and intestinal morphology of broilers.	Zhao Z, Liswaniso S, Qin N, Cao S, Wu X, Ma C, Yan C, Xu R, Sun X.	Front Vet Sci	10.3389/fvets.2024.1468847	2024
	Consolidated bioprocessing for butyric acid production from raw cassava starch by a newly isolated Clostridium butyricum SCUT620	Fu H, Yue Z, Feng J, Bao T, Yang ST, Cai Y, Wang J.	Industrial crops and products.	10.1016/j.indcrop.2022.115446	2022
	Effect of bioaugmentation using Clostridium butyricum on the start-up and the performance of continuous biohydrogen production.	Sim YB, Yang J, Kim SM, Joo HH, Jung JH, Kim DH, Kim SH.	Bioresour Technol	10.1016/j.biortech.2022.128181	2022
	Mathematical modeling of biohydrogen production via dark fermentation of fruit peel wastes by Clostridium butyricum NE95.	Elerakey N, Rasmey AM, Aboseidah AA, Hawary H.	BMC Biotechnol	10.1186/s12896-024-00925-7	2024
	Improving tolerance and 1,3-propanediol production of Clostridium butyricum using physical mutagenesis, adaptive evolution and genome shuffling.	Yun J, Zabed HM, Zhang Y, Zhang G, Zhao M, Qi X.	Bioresour Technol	10.1016/j.biortech.2022.127967	2022
	Gut-Microbiota-Derived Metabolites and Probiotic Strategies in Colorectal Cancer: Implications for Disease Modulation and Precision Therapy	Yang Y, Chang S, Hung C, Shen M, Lai C, Huang C.	Nutrients		2025
	The Isolation, Identification, and Whole-Genome Sequencing of a Potential Probiotic, Clostridium butyricum YF1, Isolated from the Intestine of the Ricefield Eel (Monopterus albus).	Feng Y, Zhang J, Zhou L, Jin J, Yue H, Ye H, Fu P, Huang L, Ruan R, Li C.	Animals (Basel)	10.3390/ani15040511	2025
	Oral microbiome and risk of lung cancer: results from a two-sample mendelian randomization analysis.	Wang C, Hu B, Liang Q, Jiang H, Yuan L, Li S.	Transl Lung Cancer Res	10.21037/tlcr-2024-1163	2025
Metabolism	Hyperspectral imaging through vacuum packaging for monitoring cheese biochemical transformation caused by Clostridium metabolism.	Reis MM, Dixit Y, Carr A, Tu C, Palevich F, Gupta T, Reis MG.	Food Res Int	10.1016/j.foodres.2023.112866	2023
	Multiplex-PCR Detection of Clostridium tyrobutyricum, Clostridium butyricum, and Clostridium sporogenes in Raw Milk for Cheesemaking.	Floris I, Martucci F, Romano A, Marello G, Ligotti C, Bianchi DM.	Life (Basel)	10.3390/life14091093	2024
	Perioperative administration of CBM588 in colorectal cancer radical surgery: A single-center, randomized controlled trial.	Yang Y, Guo Y, Ding Y, Li J, Liang L, Shi D, Li X, Ma Y.	Cell Rep Med	10.1016/j.xcrm.2025.102234	2025
	Effects of Clostridium butyricum on Production Performance and Bone Development of Laying Hens.	Huang J, Cui L, Lin H, Song M, Sun S.	Vet Sci	10.3390/vetsci11040160	2024
	Butyrogenic effect of galactosyl and mannosyl carbohydrates and their regulation on piglet intestinal microbiota.	Cao L, Liu Z, Yu Y, Liang Q, Wei X, Sun H, Fang Y, Zhu C, Kong Q, Fu X, Mou H.	Appl Microbiol Biotechnol	10.1007/s00253-023-12436-0	2023
	Clostridium butyricum MIYAIRI 588 contributes to the maintenance of intestinal microbiota diversity early after haematopoietic cell transplantation.	Fukushima K, Kudo H, Oka K, Hayashi A, Onizuka M, Kusakabe S, Hino A, Takahashi M, Takeda K, Mori M, Ando K, Hosen N.	Bone Marrow Transplant	10.1038/s41409-024-02250-1	2024
	Hypothesized mechanism of amelioration of colitis by Clostridium butyricum as a hydrogen-producing bacterium.	Ichiakwa Y, Sato B, Hirano SI, Takefuji Y, Takefuji Y, Satoh F.	Med Gas Res	10.4103/2045-9912.390251	2024
	Role of intestinal SCFAs homeostasis in the hepatoprotective effect of Clostridium butyricum in T2DM.	Yan M, Pan D, Chen L, Pang J, Shao Y, Cheng Q, Liu Y, Yin Z, Jiang Z, Sha P, Huang Y, Fan Y, Qian S, Wang T, Lu Q, Yang T.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00824-5	2025
	Uncovering the mechanism of Clostridium butyricum CBX 2021 to improve pig health based on in vivo and in vitro studies.	Liu X, Qiu X, Yang Y, Wang J, Wang Q, Liu J, Huang J, Yang F, Liu Z, Qi R.	Front Microbiol	10.3389/fmicb.2024.1394332	2024
	Amelioration of ammonia-induced intestinal oxidative stress by dietary Clostridium butyricum in giant freshwater prawn (Macrobrachium rosenbergii).	Sun C, Tadese DA, Wangari MR, Zhou Q, Zheng X, Liu B, Tamiru M, Dagne A, Janssens GPJ, Zhao Y.	Fish Shellfish Immunol	10.1016/j.fsi.2022.11.007	2022
	Whole cell of pure Clostridium butyricum CBT-1 from anaerobic bioreactor effectively hydrolyzes agro-food waste into biohydrogen.	Shah TA, Zhihe L, Zhiyu L, Zhang A, Lu D, Fang W, Xuan H.	Environ Sci Pollut Res Int	10.1007/s11356-022-22443-9	2023
Genetics	Emerging Pathogens in Planetary Health and Lessons from Comparative Genome Analyses of Three Clostridia Species.	Tanwar AS, Shruptha P, Jnana A, Brand A, Ballal M, Satyamoorthy K, Murali TS.	OMICS	10.1089/omi.2023.0034	2023
	Role of Clostridium butyricum, Bacillus subtilis, and algae-sourced beta-1,3 glucan on health in grass turtle.	Luo M, Feng G, Ke H.	Fish Shellfish Immunol	10.1016/j.fsi.2022.09.034	2022
	Parity influences on the infant gut microbiome development: a longitudinal cohort study.	Prasad R, Angelova A, Subramanian P, Namasivayam S, Chen Q, Banks K, Levy S, Maxwell GL, Hourigan SK.	Gut Microbes	10.1080/19490976.2025.2557980	2025
Metabolism	Effects of compatibility of Clostridium butyricum and Bacillus subtilis on growth performance, lipid metabolism, antioxidant status and cecal microflora of broilers during the starter phase.	Zhao X, Zhuang J, Zhang F, Li H, Yu J, Wang C, Lv T, Li Q, Zhang J.	Anim Biosci	10.5713/ab.24.0132	2024
	The Relationship Between the Modulation of Intestinal Microbiota and the Response to Immunotherapy in Patients with Cancer.	Rados L, Golcic M, Mikolasevic I.	Biomedicines	10.3390/biomedicines13010096	2025
	Metatranscriptomic Analysis Reveals the Coexpression of Hydrogen-Producing and Homoacetogenesis Genes in Dark Fermentative Reactors Operated at High Substrate Loads.	Montoya-Rosales JJ, Ontiveros-Valencia A, Esquivel-Hernandez DA, Etchebehere C, Celis LB, Razo-Flores E.	Environ Sci Technol	10.1021/acs.est.3c02066	2023
	Effects of dietary probiotic (Clostridium butyricum I9, C. butyricum G15, or Paraclostridium bifermentans X13) on growth, digestive enzyme activities, immunity, and intestinal microbiota of Pacific white shrimp (Penaeus vannamei).	Yang W, Liang H, Chen R, Du Z, Deng T, Zheng Y, Song Y, Duan Y, Lin J, Bakky MAH, Tran NT, Zhang M, Li S.	Front Microbiol	10.3389/fmicb.2024.1479446	2024
	Association between Nutrition Protocol with Clostridium butyricum MIYAIRI 588 and Reduced Incidence of Clostridioides difficile Infection in Critically Ill Patients: A Single-Center, Before-and-After Study.	Sato T, Kudo D, Kushimoto S.	Surg Infect (Larchmt)	10.1089/sur.2022.030	2022
Metabolism	The Effect of Clostridium butyricum on Gut Microbial Changes and Functional Profiles of Metabolism in High-fat Diet-fed Rats Depending on Age and Sex.	Choi SI, Kim N, Choi Y, Nam RH, Jang JY, Cho SY.	J Neurogastroenterol Motil	10.5056/jnm23096	2024
	Analysis of the formation mechanism and regulation pathway of oat silage off-flavor based on microbial-metabolite interaction network.	Jiajie Z, Xiaochen D, Junfeng H, Mingjiu W, Gentu G.	BMC Microbiol	10.1186/s12866-025-04166-2	2025
	A case report of severe diarrhea due to cytomegalovirus infection after living donor liver transplantation: successful treatment with butyrate-producing bacteria, immunosuppressive adjustments, and anti-cytomegalovirus therapy.	Usui M, Tsuzuki N, Murai M, Ito A, Futamura A.	Fujita Med J	10.20407/fmj.2024-032	2025
	Clostridium butyricum, a butyrate-producing potential probiotic, alleviates experimental colitis through epidermal growth factor receptor activation.	Wu J, Zhou B, Pang X, Song X, Gu Y, Xie R, Liu T, Xu X, Wang B, Cao H.	Food Funct	10.1039/d2fo00478j	2022
Pathogenicity	The Gut Microbiome and Its Impact on Mood and Decision-Making: A Mechanistic and Therapeutic Review.	Diotaiuti P, Misiti F, Marotta G, Falese L, Calabro GE, Mancone S.	Nutrients	10.3390/nu17213350	2025
	Probiotic Roles of Clostridium butyricum in Piglets: Considering Aspects of Intestinal Barrier Function.	Tang X.	Animals (Basel)	10.3390/ani14071069	2024
	Clostridium butyricum Prevents Diarrhea Incidence in Weaned Piglets Induced by Escherichia coli K88 through Rectal Bacteria-Host Metabolic Cross-Talk.	Liang J, Wang S, Kou S, Chen C, Zhang W, Nie C.	Animals (Basel)	10.3390/ani14162287	2024
	Clostridium butyricum Inhibits Fat Deposition via Increasing the Frequency of Adipose Tissue-Resident Regulatory T Cells.	Li H, Jia Y, Weng D, Ju Z, Zhao Y, Liu S, Liu Y, Song M, Cui L, Sun S, Lin H.	Mol Nutr Food Res	10.1002/mnfr.202100884	2022
	Acceleration of lactate-utilizing pathway for enhancing biohydrogen production by magnetite supplementation in Clostridium butyricum.	Kim DH, Yoon JJ, Kim SH, Park JH.	Bioresour Technol	10.1016/j.biortech.2022.127448	2022
	Interaction mechanism and intervention strategy between metabolic dysfunction-associated steatotic liver disease and intestinal microbiota.	Yang W, Jin Q, Xiao D, Li X, Huang D.	Front Microbiol	10.3389/fmicb.2025.1597995	2025
	Berberine hydrochloride alleviates chronic prostatitis/chronic pelvic pain syndrome by modifying gut microbiome signaling.	Tian YQ, Ren X, Wang J, Li X, Yin YS, Guo ZH, Qin ZL, Zeng XY.	Asian J Androl	10.4103/aja202427	2024
	Management of a pregnant woman with a large cervical polyp and moderate genital bleeding in the first trimester.	Saitsu Y, Yoneda S, Fukuta K.	BMJ Case Rep	10.1136/bcr-2023-258163	2024
	Are pro- and/or synbiotics beneficial in Helicobacter pylori eradication therapy in children? A narrative review.	Daelemans S, Deseck V, Levy EI, Vandenplas Y.	Eur J Pediatr	10.1007/s00431-022-04523-7	2022
	The impact of Helicobacter pylori infection and eradication therapies on gut microbiota: a systematic review of microbial dysbiosis and its implications in gastric carcinogenesis.	Albush A, Yassine F, Abbas H, Hanna A, Saba E, Bilen M.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1592977	2025
	Schizochytrium Supplementation in Compound Feed: Effects on Growth, Metamorphosis, Intermediate Metabolism, and Intestinal Health of Bullfrogs (Lithobates catesbeianus).	Ding H, He Y, Song Y, Liang J, Li W, Xu C, Yang H.	Antioxidants (Basel)	10.3390/antiox14101208	2025
	Effects of Clostridium butyricum Capsules Combined with Rosuvastatin on Intestinal Flora, Lipid Metabolism, Liver Function and Inflammation in NAFLD Patients.	Zhu W, Yan M, Cao H, Zhou J, Xu Z.	Cell Mol Biol (Noisy-le-grand)	10.14715/cmb/2022.68.2.10	2022
	Efficacy of a feed additive consisting of Bacillus subtilis FERM BP-07462, Enterococcus lactis FERM BP-10867 and Clostridium butyricum FERM BP-10866 (BIO-THREE®) for chickens for fattening and reared for laying, turkeys for fattening and reared for breeding, and all avian species for rearing/fattening or reared for laying/breeding (TOA BIOPHARMA Co., Ltd.).	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Durjava M, Dusemund B, Kouba M, Lopez-Alonso M, Puente SL, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Villa RE, Woutersen R, Dierick N, Anguita M, Innocenti ML, Ortuno J, Tarres-Call J, Firmino JP.	EFSA J	10.2903/j.efsa.2023.8343	2023
	Clostridium butyricum isolated from giant panda can attenuate dextran sodium sulfate-induced colitis in mice.	Yu S, Xie J, Guo Q, Yan X, Wang Y, Leng T, Li L, Zhou J, Zhang W, Su X.	Front Microbiol	10.3389/fmicb.2024.1361945	2024
	Development of a new multiplex quantitative real-time polymerase chain reaction method for Clostridium butyricum, Clostridium sporogenes and Clostridium tyrobutyricum detection in cheese	Sahiner A, Caliskan S, Halat E.	Lebensm Wiss Technol		2022
Phylogeny	Microbial community dynamics of a sequentially fed anaerobic digester treating solid organic waste.	Lee H, Fitamo TM, Nesbo CL, Guilford NGH, Kanger K, Yang MI, Edwards EA.	FEMS Microbiol Ecol	10.1093/femsec/fiad017	2023
	Gut microbiota dynamics and fecal SCFAs after colonoscopy: accelerating microbiome stabilization by Clostridium butyricum.	Chen Z, Yu L, Liu J, Kong J, Deng X, Guo X, Shan J, Zhou D, Li W, Lin Y, Huang W, Zeng W, Shi X, Bai Y, Fan H.	J Transl Med	10.1186/s12967-024-05031-y	2024
	Long-term dechlorination of cis-DCE to ethene with co-immobilized Dehalococcoides mccartyi BAV1 and Clostridium butyricum in silica gel system.	Lu CW, Kao CM, Le NN, Lin CC, Chen SC.	J Hazard Mater	10.1016/j.jhazmat.2022.128355	2022
	Effects of Dietary Supplementation with Three Different Probiotics on Growth Performance, Antioxidant Capacity, and Intestinal Microbiota in Grass Carp (Ctenopharyngodon idella).	Zhu W, Yi Y, Zou Z, Li H, Liang T, Shi Q, Liu L, Su J.	Microorganisms	10.3390/microorganisms13061222	2025
	Akkermansia muciniphila: a microbial guardian against oxidative stress-gut microbiota crosstalk and clinical prospects.	Ye WY, Cai Y.	J Transl Med	10.1186/s12967-025-07149-z	2025
	Mitigation of antibiotic resistome in swine manure by black soldier fly larval conversion combined with composting.	Zhao Z, Yu C, Yang C, Gao B, Jimenez N, Wang C, Li F, Ao Y, Zheng L, Huang F, Tomberlin JK, Ren Z, Yu Z, Zhang J, Cai M.	Sci Total Environ	10.1016/j.scitotenv.2023.163065	2023
	Probiotic Spore-Based Oral Drug Delivery System for Enhancing Pancreatic Cancer Chemotherapy by Gut-Pancreas-Axis-Guided Delivery.	Han ZY, Chen QW, Fu ZJ, Cheng SX, Zhang XZ.	Nano Lett	10.1021/acs.nanolett.2c03131	2022
	Strains producing different short-chain fatty acids alleviate DSS-induced ulcerative colitis by regulating intestinal microecology.	Yang S, Shang J, Liu L, Tang Z, Meng X.	Food Funct	10.1039/d2fo01577c	2022
Enzymology	Functional and Structural Roles of the Dimer Interface in the Activity and Stability of Clostridium butyricum 1,3-Propanediol Oxidoreductase.	Parvez A, Ravikumar Y, Bisht R, Yun J, Wang Y, Chandrika SP, Zabed HM, Qi X.	ACS Synth Biol	10.1021/acssynbio.1c00555	2022
	Cleanup chlorinated ethene-polluted groundwater using an innovative immobilized Clostridium butyricum column scheme: A pilot-scale study.	Lo KH, Lu CW, Chien CC, Sheu YT, Lin WH, Chen SC, Kao CM.	J Environ Manage	10.1016/j.jenvman.2022.114836	2022
	The Potential Role of Probiotics, Especially Butyrate Producers, in the Management of Gastrointestinal Mucositis Induced by Oncologic Chemo-Radiotherapy.	Cazzaniga M, Cardinali M, Di Pierro F, Zonzini GB, Palazzi CM, Gregoretti A, Zerbinati N, Guasti L, Bertuccioli A.	Int J Mol Sci	10.3390/ijms25042306	2024
	The Role of Short-Chain Fatty Acids, Particularly Butyrate, in Oncological Immunotherapy with Checkpoint Inhibitors: The Effectiveness of Complementary Treatment with Clostridium butyricum 588	Cazzaniga M, Cardinali M, Di Pierro F, Zonzini G, Palazzi C, Gregoretti A, Zerbinati N, Guasti L, Matera M, Cavecchia I, Bertuccioli A.	Microorganisms		2024
	Abemaciclib-associated acute interstitial nephritis successfully treated with glucocorticoids: a case report and literature review.	Kumano M, Maeoka Y, Teragawa Y, Yanagidani H, Yoshida M, Takahashi A, Masaki T.	BMC Nephrol	10.1186/s12882-025-04442-3	2025
	Effects of the Clostridium butyricum on growth performance, antioxidant capacity, immunity and disease resistance of Litopenaeus Vannamei fed with cottonseed protein concentrate (CPC) replacement of fishmeal in diet.	Li W, Pan L, Liu H, Tan B, Dong X, Yang Q, Chi S, Zhang S, Xie R.	Fish Shellfish Immunol	10.1016/j.fsi.2022.05.030	2022
	Probiotics including Clostridium butyricum, Enterococcus faecium, and Bacillus subtilis may prevent recurrent spontaneous preterm delivery.	Arai EN, Yoneda S, Yoneda N, Ito M, Tsuda S, Shiozaki A, Nohira T, Hyodo H, Kumazawa K, Suzuki T, Nagasaki S, Makino S, Saito S.	J Obstet Gynaecol Res	10.1111/jog.15166	2022
	Bacteriophages, Antibiotics and Probiotics: Exploring the Microbial Battlefield of Colorectal Cancer	Volovat C, Cosovanu M, Ostafe M, Augustin I, Volovat C, Georgescu B, Volovat S.	Int J Mol Sci		2025
	Clostridium butyricum-fermented Chinese herbal medicine enhances the immunity by modulating the intestinal microflora of largemouth bass (Micropterus salmoides)	Meng X, Cai H, Li H, You F, Jiang A, Hu W, Li K, Zhang X, Zhang Y, Chang X, Yang G, Zhou Z.	Aquaculture		2022
	Ethanol-Induced Dysbiosis and Systemic Impact: A Meta-Analytical Synthesis of Human and Animal Research.	Alexandrescu L, Tofolean IT, Tofolean DE, Nicoara AD, Twakor AN, Rusu E, Preotesoiu I, Dumitru E, Dumitru A, Tocia C, Herlo A, Alexandrescu DM, Popescu I, Cimpineanu B.	Microorganisms	10.3390/microorganisms13092000	2025
	The Protective Effects of Lactobacillus reuteri Combined With Clostridium butyricum Miyairi 588 on Intestinal Barrier Function, Water Transport, and Oxidative Stress in a Rat Model of 5FU-Induced Diarrhea.	Tang SC, Chuang WC, Liao JM, Tsai YH, Chen LC, Liao JW, Ko JL, Ou CC.	Food Sci Nutr	10.1002/fsn3.70318	2025
	A medical and molecular approach to kefir as a therapeutic agent of human microbiota.	Yegin Z, Sudagidan M.	Int J Vitam Nutr Res	10.1024/0300-9831/a000765	2024
Phylogeny	Preliminary study on the potential impact of probiotic combination therapy on Helicobacter pylori infection in children using 16S gene sequencing and untargeted metabolomics approach.	Yan Y, Dong L, Xu J, Zhang Z, Jia P, Zhang J, Chen W, Gao W.	Front Microbiol	10.3389/fmicb.2024.1487978	2024
	Microbial signatures in metastatic cancer.	Bautista J, Fuentes-Yepez MP, Adatty-Molina J, Lopez-Cortes A.	Front Med (Lausanne)	10.3389/fmed.2025.1654792	2025
	Efficacy of probiotics as adjuvant therapy in bronchial asthma: a systematic review and meta-analysis.	Balan D, Baral T, Manu MK, Mohapatra AK, Miraj SS.	Allergy Asthma Clin Immunol	10.1186/s13223-024-00922-7	2024
	Clostridium butyricum Strain CCFM1299 Reduces Obesity via Increasing Energy Expenditure and Modulating Host Bile Acid Metabolism.	Liao J, Liu Y, Yao Y, Zhang J, Wang H, Zhao J, Chen W, Lu W.	Nutrients	10.3390/nu15204339	2023
	Solid-State Fermentation of Wheat Bran with Clostridium butyricum: Impact on Microstructure, Nutrient Release, Antioxidant Capacity, and Alleviation of Ulcerative Colitis in Mice.	Zhang H, Zhang M, Zheng X, Xu X, Zheng J, Hu Y, Mei Y, Liu Y, Liang Y.	Antioxidants (Basel)	10.3390/antiox13101259	2024
	Impact of Acid Suppressants on the Development of Clostridioides difficile Infection and Possible Preventive Effects of Probiotic Formulations.	Shiraishi C, Kato H, Iwamoto T.	Infect Drug Resist	10.2147/idr.s543864	2025
	Effects of supplementation with freeze-dried Clostridium butyricum powder after replacement of fishmeal with cottonseed protein concentrate on growth performance, immune response, and intestinal microbiota of Litopenaeus vannamei.	Wang Q, Fan D, Hu Y, Liu H, Tan B, Xie S, Chen Q.	BMC Vet Res	10.1186/s12917-024-04372-6	2024
	Effect of the Combination of Clostridium butyricum and Mycelium of Phellinus igniarius on Intestinal Microbiota and Serum Metabolites in DSS-Induced Colitis.	Zhao R, Zhang Q, Huang T, Tian Y, Guan G, Lin Y.	Nutrients	10.3390/nu16010153	2024
	Evaluation of paraprobiotic applicability of Clostridium butyricum CBG01 in improving the growth performance, immune responses and disease resistance in Pacific white shrimp, Penaeus vannamei	Luo K, Tian X, Wang B, Wei C, Wang L, Zhang S, Liu Y, Li T, Dong S.	Aquaculture	10.1016/j.aquaculture.2021.737041	2021
Metabolism	Isolation and characterization of a newly identified Clostridium butyricum strain SCUT343-4 for 1,3-propanediol production.	Lan Y, Feng J, Guo X, Fu H, Wang J.	Bioprocess Biosyst Eng	10.1007/s00449-021-02610-x	2021
	The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8⁺ T cells in mice.	Hua D, Yang Q, Li X, Zhou X, Kang Y, Zhao Y, Wu D, Zhang Z, Li B, Wang X, Qi X, Chen Z, Cui G, Hong W.	mSystems	10.1128/msystems.01567-24	2025
Pathogenicity	Supplementation of Clostridium butyricum Alleviates Vascular Inflammation in Diabetic Mice.	Zhou T, Qiu S, Zhang L, Li Y, Zhang J, Shen D, Zhao P, Yuan L, Zhao L, Duan Y, Xing C.	Diabetes Metab J	10.4093/dmj.2023.0109	2024
	The Mixture of Saccharomyces cerevisiae and Clostridium butyricum Could Promote Rumen Fermentation and Improve the Growth Performance of Goats in Hot Summer.	Cai L, Li M, Zhou S, Xu Q.	Metabolites	10.3390/metabo13010104	2023
	New evidence for the protective effect of gut microbiota regulation of ferroptosis-related proteins against osteoporosis.	Guo Z, Di J, Qin Y, Wang X, Tian Z, Long Y, Wang Y, Xiang C.	World J Microbiol Biotechnol	10.1007/s11274-025-04590-6	2025
	Clostridium butyricum Ameliorates the Effect of Coprophagy Prevention on Hepatic Lipid Synthesis in Rabbits via the Gut-Liver Axis.	Li Z, Chen M, Zhang R, Wang Z, He H, Wan Z, Li H, Cai H, Chen Z, Li M, Xu H.	Int J Mol Sci	10.3390/ijms242417554	2023
Phylogeny	The interaction between rumen microbiota and neurotransmitters plays an important role in the adaptation of phenological changes in Tibetan sheep.	Huang W, Sha Y, Chen Q, Chen X, Gao M, Liu X, He Y, Gao X, Hu J, Wang J, Li S, Hao Z, He Y.	BMC Vet Res	10.1186/s12917-025-04823-8	2025
	Characterization of argonaute nucleases from mesophilic bacteria Pseudobutyrivibrio ruminis.	Xu X, Yang H, Dong H, Li X, Liu Q, Feng Y.	Bioresour Bioprocess	10.1186/s40643-024-00797-x	2024
	Low-Energy Trauma: Severe Liver Injury in an Elderly Patient from a Seated Fall.	Katsuki NE, Eguchi H, Hirata R, Aihara H, Tago M.	Am J Case Rep	10.12659/ajcr.946094	2024
	Potential and characteristics of bio-H₂ production from brewery wastewater by a maltose-preferring butyrate-type producer: Investigation in batch and semi-continuous cultures.	Wang Y, Chen M, Xu J, Qi N, Dong L, Cao G, Zhao X.	Environ Res	10.1016/j.envres.2021.112457	2022
	The effect of Miya on skeletal muscle changes by regulating gut microbiota in rats with osteoarthritis through AMPK pathway.	Wang S, Duan Z, Li Z, Yang D, Lu H, Zhang Y, Fu Y, Guan Y, Li G, Qian F, Xu T.	BMC Musculoskelet Disord	10.1186/s12891-024-08203-5	2024
	Dietary supplementation with synbiotics improves growth performance, antioxidant status, immune function, and intestinal barrier function in broilers subjected to cyclic heat stress.	Du M, Cheng Y, Chen Y, Wang S, Zhao H, Wen C, Zhou Y.	Environ Sci Pollut Res Int	10.1007/s11356-022-23385-y	2023
	Engineering bacteria for cancer immunotherapy by inhibiting IDO activity and reprogramming CD8+ T cell response.	Wang H, Xu F, Yao C, Dai H, Xu J, Wu B, Tian B, Shi X, Wang C.	Proc Natl Acad Sci U S A	10.1073/pnas.2412070121	2024
	Sodium butyrate regulates macrophage polarization by TGR5/beta-arrestin2 in vitro.	Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L.	Mol Med	10.1186/s10020-025-01096-7	2025
	Overexpression of pEGF improved the gut protective function of Clostridium butyricum partly through STAT3 signal pathway.	Ma M, Zhao Z, Liang Q, Shen H, Zhao Z, Chen Z, He R, Feng S, Cao D, Gan G, Ye H, Qiu W, Deng J, Ming F, Jia J, Sun C, Li J, Zhang L.	Appl Microbiol Biotechnol	10.1007/s00253-021-11472-y	2021
Genetics	Exploiting heterologous and endogenous CRISPR-Cas systems for genome editing in the probiotic Clostridium butyricum.	Zhou X, Wang X, Luo H, Wang Y, Wang Y, Tu T, Qin X, Su X, Bai Y, Yao B, Huang H, Zhang J.	Biotechnol Bioeng	10.1002/bit.27753	2021
	Effects of dietary Clostridium butyricum and rumen protected fat on meat quality, oxidative stability, and chemical composition of finishing goats.	Zhang M, Zhang Z, Zhang X, Lu C, Yang W, Xie X, Xin H, Lu X, Ni M, Yang X, Lv X, Jiao P.	J Anim Sci Biotechnol	10.1186/s40104-023-00972-8	2024
	Knowledge graph-derived feed efficiency analysis via pig gut microbiota.	Zhang J, Jiang Q, Du Z, Geng Y, Hu Y, Tong Q, Song Y, Zhang HY, Yan X, Feng Z.	Sci Rep	10.1038/s41598-024-64835-6	2024
	Interplay between Bile Acids and Intestinal Microbiota: Regulatory Mechanisms and Therapeutic Potential for Infections.	Li W, Chen H, Tang J.	Pathogens	10.3390/pathogens13080702	2024
	Association of Clostridium butyricum Therapy Using the Live Bacterial Product CBM588 with the Survival of Patients with Lung Cancer Receiving Chemoimmunotherapy Combinations.	Tomita Y, Sakata S, Imamura K, Iyama S, Jodai T, Saruwatari K, Hamada S, Akaike K, Anai M, Fukusima K, Takaki A, Tsukamoto H, Goto Y, Motozono C, Sugata K, Satou Y, Ueno T, Ikeda T, Sakagami T.	Cancers (Basel)	10.3390/cancers16010047	2023
	Clostridium butyricum alone or combined with 1, 25-dihydroxyvitamin D₃ improved early-stage broiler health by modulating intestinal flora.	Yu Y, Li Q, Zhang H, Wu Y, Zhang R, Yue M, Yang C, Cao G.	J Appl Microbiol	10.1111/jam.15180	2022
Genetics	Genetic evidence of bidirectional mendelian randomization study on the causality between gut microbiome and respiratory diseases contributes to gut-lung axis.	Zhou X, Shen S, Wang Z.	Sci Rep	10.1038/s41598-024-77273-1	2024
	Compound probiotics promote the growth of piglets through activating the JAK2/STAT5 signaling pathway.	Li Z, Dai X, Yang F, Zhao W, Xiong Z, Wan W, Wu G, Xu T, Cao H.	Front Microbiol	10.3389/fmicb.2025.1480077	2025
	Probiotics/synbiotics supplementation reduce the infection incidence in patients undergoing resection for colorectal cancer: an umbrella review.	Gao S, Liao X, He Y, Yang J.	Front Microbiol	10.3389/fmicb.2025.1635409	2025
	Multiplex genetic manipulations in Clostridium butyricum and Clostridium sporogenes to secrete recombinant antigen proteins for oral-spore vaccination.	Zhang Y, Bailey TS, Hittmeyer P, Dubois LJ, Theys J, Lambin P.	Microb Cell Fact	10.1186/s12934-024-02389-y	2024
	Gut microbiota shapes social dominance through modulating HDAC2 in the medial prefrontal cortex.	Wang T, Xu J, Xu Y, Xiao J, Bi N, Gu X, Wang HL.	Cell Rep	10.1016/j.celrep.2022.110478	2022
	Production of biological hydrogen from Quinoa residue using dark fermentation and estimation of its microbial diversity.	Dursun N.	Heliyon	10.1016/j.heliyon.2024.e25018	2024
	Effects of adding a kind of compound bio-enzyme to the diet on the production performance, serum immunity, and intestinal health of Pekin ducks.	Li Y, Zhou J, Guo T, Zhang H, Cao C, Cai Y, Zhang J, Li T, Zhang J.	Poult Sci	10.1016/j.psj.2024.104506	2025
	Effects of dietary Clostridium butyricum on the growth performance, digestion, and intestinal health of spotted sea bass (Lateolabrax maculatus).	Kong L, Ma J, Zhou S, Lin H, Long Z, Qin H, Liu L, Lin Y, Huang Z, Li Z.	Front Immunol	10.3389/fimmu.2023.1181471	2023
	The impact of prenatal use of oral Clostridium butyricum on maternal group B Streptococcus colonization: A retrospective study.	Lai TJ, Wang YH, Chong E, Lin YM, Huang CC, Feng KJ, Teng SW.	Taiwan J Obstet Gynecol	10.1016/j.tjog.2021.03.009	2021
	Effect of multi-strain probiotics on the performance of AA+ male broilers.	Zou Q, Meng W, Wang T, Liu X, Li D.	Front Vet Sci	10.3389/fvets.2022.1098807	2022
	Modification of the conditions of the authorisation of Clostridium butyricum FERM BP-2789 (Miya-Gold®) for chickens for fattening, chickens reared for laying and minor avian species (excluding laying birds) (Miyarisan Pharmaceutical Co. Ltd).	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Durjava M, Kouba M, Lopez-Alonso M, Lopez Puente S, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brozzi R, Pettenati E, Revez J, Anguita M, Galobart J, Ortuno J.	EFSA J	10.2903/j.efsa.2023.7818	2023
	Relationship between mild traumatic brain injury and the gut microbiome: A scoping review.	Aghakhani N.	J Neurosci Res	10.1002/jnr.25004	2022
	Effects of Clostridium butyricum on growth, digestive enzyme activity, antioxidant capacity and gut microbiota in farmed tilapia (Oreochromis niloticus)	Zhang M, Dong B, Lai X, Chen Z, Hou L, Shu R, Huang Y, Shu H.	Aquac Res	10.1111/are.15009	2021
	A diverse set of solubilized natural fibers drives structure-dependent metabolism and modulation of the human gut microbiota.	Maldonado-Gomez MX, Ng KM, Drexler RA, Conner AMS, Vierra CG, Krishnakumar N, Gerber HM, Taylor ZR, Treon JL, Ellis M, Garcia JKA, Cerney JP, Chapin DG, Kerns RT, Marcobal AM, Watkins SM, Amicucci MJ.	mBio	10.1128/mbio.00470-25	2025
	49 Exploring relationships between forage nutrients and the equine fecal microbiome	Weinert JR, Biddle AS, Williams CA.	J Equine Vet Sci		2022
	47 Integrated warm- and cool-season grass rotational grazing management and the equine fecal microbiome	Weinert JR, Biddle AS, Williams CA.	J Equine Vet Sci		2022
	Clostridium butyricum Alleviates Gut Microbiota Alteration-Induced Bone Loss after Bariatric Surgery by Promoting Bone Autophagy.	Shang X, Zhang X, Du C, Ma Z, Jin S, Ao N, Yang J, Du J.	J Pharmacol Exp Ther	10.1124/jpet.120.000410	2021
	Botulism in the Highlands: Understanding the High-Altitude Effect.	Almomen M, Memish Z.	J Epidemiol Glob Health	10.1007/s44197-025-00403-z	2025
	Prosthetic Gait Achievement in an Elderly Patient with Chronic Limb-threatening Ischemia and High Complications Using a Novel Lipoprotein Apheresis.	Tashima H, Ochi M, Hori R, Hachisuka A, Itoh H, Matsushima Y, Saeki S.	Prog Rehabil Med	10.2490/prm.20240039	2024
	Efficacy and safety of Chinese herbal medicine in treating postcholecystectomy diarrhea: A systematic review and meta-analysis	Sun Y, Zhang Y, Wang Z, Liu Q, Mo J.	Medicine (Baltimore)		2024
	13 Impact of Biome Fix on the fecal microbiome response to antibiotic challenge in horses	Wagner A, Splan RK, Biddle AS, Girard ID.	J Equine Vet Sci		2022
	The performance gut: a key to optimizing performance in high-level athletes: a systematic scoping review.	Carlone J, Parisi A, Fasano A.	Front Sports Act Living	10.3389/fspor.2025.1641923	2025
Metabolism	Analysis of the core genome and pangenome of Clostridium butyricum.	Zou W, Ye G, Zhang K, Yang H, Yang J.	Genome	10.1139/gen-2020-0072	2021
	Potential Inflammatory Biomarkers and Differential Gut Microbiota in Cognitive Impairment After Ischemic Stroke	Wu L, Jiang Y, Xu W, Wang L, Li L, Zhang C, Huang K, Yang Y, Dai J, Zhou F.	Neuropsychiatr Dis Treat		2025
	Prophylactic Feeding of Clostridium butyricum and Saccharomyces cerevisiae Were Advantageous in Resisting the Adverse Effects of Heat Stress on Rumen Fermentation and Growth Performance in Goats.	Xue L, Wang D, Zhang F, Cai L.	Animals (Basel)	10.3390/ani12182455	2022
	Lactiplantibacillus plantarum 22 A-3 ameliorates leaky gut in mice through its anti-inflammatory effects.	Kobayashi T, Kessoku T, Iwaki M, Nogami A, Yoneda M, Saito S, Yamana Y, Nishitani Y, Kuwahara H, Nakajima A.	Sci Rep	10.1038/s41598-025-87428-3	2025
	Effect of Indian monsoon on the glacial airborne bacteria over the Tibetan Plateau.	Qi J, Ji M, Wang W, Zhang Z, Liu K, Huang Z, Liu Y.	Sci Total Environ	10.1016/j.scitotenv.2022.154980	2022
Phylogeny	The effect of a polystyrene nanoplastic on the intestinal microbes and oxidative stress defense of the freshwater crayfish, Procambarus clarkii.	Han M, Gao T, Liu G, Zhu C, Zhang T, Sun M, Li J, Ji F, Si Q, Jiang Q.	Sci Total Environ	10.1016/j.scitotenv.2022.155722	2022
	Probiotics ameliorate growth retardation of glyphosate by regulating intestinal microbiota and metabolites in crucian carp (Carassius auratus).	Yan B, Han J, Sun Y, Lei L, Yuan J, Qiao Z, Men J, Wang X, Guo Y, Wang Q, Zhou B.	Sci Total Environ	10.1016/j.scitotenv.2022.158260	2022
	Potential effects of dietary probiotics with Chinese herb polysaccharides on the growth performance, immunity, disease resistance, and intestinal microbiota of rainbow trout (Oncorhynchus mykiss)	Zhou B, Wang X, Wang Y, Liu H, Yu X, Li L, Ye H, Wang S, Gai C, Xu L, Diao J, Guo P.	Journal of the World Aquaculture Society.	10.1111/jwas.12757	2021
	Clostridium butyricum Probiotic Feed Additive: Modulation of Sow Milk Metabolomics and Mitigation of Pre-Weaning Piglet Diarrhea.	Ruampatana J, Suwimonteerabutr J, Homyog K, Mekboonsonglarp W, Kanjanavaikoon K, der Veken WV, Poonyachoti S, Feyera T, Settachaimongkon S, Nuntapaitoon M.	Animals (Basel)	10.3390/ani14142098	2024
	Gut microbiota and metabolites: emerging prospects in the treatment of non-small cell lung cancer.	Jiao JM, Liu CG, Zang D, Chen J.	Front Immunol	10.3389/fimmu.2025.1638942	2025
	Effects of Clostridium butyricum on Intestinal Microflora and Metabolism of Eriocheir sinensis.	Gao X, Liu X, Wang Y, Wang T, Fang D, Hu K.	Int J Mol Sci	10.3390/ijms241813784	2023
	Tapeworm Infection Diagnosed after Campylobacter jejuni-induced Enteritis.	Ozaka S, Soma R, Takahashi H, Shimomori Y, Fukuda M, Tsutsumi K, Hirashita Y, Fukuda K, Ogawa R, Mizukami K, Kagoshima Y, Sachi N, Kamiyama N, Hasegawa H, Kobayashi T, Kodama M, Murakami K.	Intern Med	10.2169/internalmedicine.3388-23	2024
	Effect of dietary Clostridium butyricum and different feeding patterns on growth performance, antioxidant and immune capacity in freshwater prawn (Macrobrachium rosenbergii)	Wangari MR, Gao Q, Sun C, Liu B, Song C, Tadese DA, Zhou Q, Zhang H, Liu B.	Aquac Res	10.1111/are.14865	2021
	Effects of probiotics on the prevention and treatment of children with allergic rhinitis: a meta-analysis of randomized controlled trials.	Luo X, Wang H, Liu H, Chen Y, Tian L, Ji Q, Xie D.	Front Pediatr	10.3389/fped.2024.1352879	2024
	Probiotics ameliorate endocrine disorders via modulating inflammatory pathways: a systematic review.	Nemati M, Ebrahimi B, Montazeri-Najafabady N.	Genes Nutr	10.1186/s12263-024-00743-8	2024
	Effects of Clostridium butyricum on growth performance, meat quality, and intestinal health of broilers.	Li Z, Long L, Jin X, Li Y, Wu Q, Chen X, Geng Z, Zhang C.	Front Vet Sci	10.3389/fvets.2023.1107798	2023
	Positive effects of dietary Clostridium butyricum supplementation on growth performance, antioxidant capacity, immunity and viability against hypoxic stress in largemouth bass.	Li P, Chen X, Hou D, Chen B, Peng K, Huang W, Cao J, Zhao H.	Front Immunol	10.3389/fimmu.2023.1190592	2023
Genetics	Genomic characterisation and traceability analysis of a Clostridium botulinum strain involved in a food poisoning incident.	Li G, Wang H, Zhang Y, Yan J, Duan Z, Pang L, Xiong X, Cha Q, Zhao S, Hou M, Liu Y.	BMC Infect Dis	10.1186/s12879-025-10700-4	2025
	Assessment of Perceived Effort Through On-Field Hydration Monitoring: A Case Analysis.	Bertuccioli A, Cannataro R, Sisti D, Zonzini GB, Cazzaniga M, Cardinali M, Di Pierro F, Gregoretti A, Zerbinati N, Matera M, Cavecchia I, Palazzi CM.	Life (Basel)	10.3390/life14111447	2024
	Clostridium butyricum and Its Culture Supernatant Alleviate the Escherichia coli-Induced Endometritis in Mice.	Mun C, Cai J, Hu X, Zhang W, Zhang N, Cao Y.	Animals (Basel)	10.3390/ani12192719	2022
	Probiotic-Vaccine Synergy in Fish Aquaculture: Exploring Microbiome-Immune Interactions for Enhanced Vaccine Efficacy.	Tayyab M, Islam W, Waqas W, Zhang Y.	Biology (Basel)	10.3390/biology14060629	2025
	Lacticaseibacillus rhamnosus Infective Endocarditis Complicated by Multifocal Mycotic Aneurysms in an Immunocompetent Patient: A Case Report.	Ito T, Okuyama M, Takahashi Y, Ohkusu K, Yokota K.	Cureus	10.7759/cureus.68056	2024
	Prevalence and influencing factors of probiotic usage among colorectal cancer patients in China: A national database study.	Yao D, He W, Hu Y, Yuan Y, Xu H, Wang J, Dai H.	PLoS One	10.1371/journal.pone.0291864	2023
	Hepatectomy for massive hepatic necrosis after transcatheter arterial embolization hemostasis for hepatic hemorrhage following hepatic trauma: A case report.	Hanaki T, Tokuyasu N, Yata S, Kishino M, Murakami Y, Shishido Y, Miyatani K, Kihara K, Matsunaga T, Yamamoto M, Sakamoto T, Hasegawa T, Fujiwara Y.	Clin Case Rep	10.1002/ccr3.7888	2023
	Characterization of gut dominant microbiota in obese patients with nonalcoholic fatty liver disease.	Jin LT, Xu MZ.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1113643	2023
	Probiotic Clostridium butyricum ameliorated motor deficits in a mouse model of Parkinson's disease via gut microbiota-GLP-1 pathway.	Sun J, Li H, Jin Y, Yu J, Mao S, Su KP, Ling Z, Liu J.	Brain Behav Immun	10.1016/j.bbi.2020.10.014	2021
	Hypomagnesemia Causing Convulsions in a Patient Taking a Proton Pump Inhibitor: A Case Report.	Sato T, Ohashi R, Konishi K, Cho T, Ichibayashi R.	Cureus	10.7759/cureus.76727	2025
	Protective effects of Clostridium butyricum against oxidative stress induced by food processing and lipid-derived aldehydes in Caco-2 cells.	Li J, Shen H, Zhao Z, Cao D, Zeng M, Cai H, Wei J, Fan Q, Deng J, Ming F, Ma M, Liang Q, Jia J, Zhang S, Zhang L.	Appl Microbiol Biotechnol	10.1007/s00253-020-10896-2	2020
	Preoperative Hemoglobin Level as Predictor of the Development of High-output Stoma in Rectal Cancer Surgery.	Kawazoe T, Ohgaki K, Fujinaka Y, Wang H, Morita K, Nakanishi R, Ikeda Y.	Cancer Diagn Progn	10.21873/cdp.10270	2023
	Saccharomyces cerevisiae and Clostridium butyricum Could Improve B-Vitamin Production in the Rumen and Growth Performance of Heat-Stressed Goats.	Cai L, Hartanto R, Xu Q, Zhang J, Qi D.	Metabolites	10.3390/metabo12080766	2022
	Sequential fed-batch fermentation of 1,3-propanediol from glycerol by Clostridium butyricum DL07.	Wang XL, Zhou JJ, Shen JT, Zheng YF, Sun YQ, Xiu ZL.	Appl Microbiol Biotechnol	10.1007/s00253-020-10931-2	2020
	Role of probiotics in preventing Clostridioides difficile infection in older adults: an integrative review.	Barbosa MLL, Albano MO, Martins CDS, Warren CA, Brito GAC.	Front Med (Lausanne)	10.3389/fmed.2023.1219225	2023
	The biotherapeutic Clostridium butyricum MIYAIRI 588 strain potentiates enterotropism of Rorgammat⁺Treg and PD-1 blockade efficacy.	Paz Del Socorro T, Oka K, Boulard O, Takahashi M, Poulin LF, Hayashi A, Chamaillard M.	Gut Microbes	10.1080/19490976.2024.2315631	2024
	Non-lactic acid bacteria probiotics isolated from intestine or various circumstances.	Lee NK, Jang HJ, Paik HD.	Food Sci Biotechnol	10.1007/s10068-024-01608-x	2024
	Coeliac disease and microbiota: is it time for personalised biotics intervention? A scoping review.	Valitutti F, Cavalli E, Leter B, Leonard M, Alessio F, Cucchiara S.	BMJ Nutr Prev Health	10.1136/bmjnph-2024-001100	2025
	Association of Probiotic Clostridium butyricum Therapy with Survival and Response to Immune Checkpoint Blockade in Patients with Lung Cancer.	Tomita Y, Ikeda T, Sakata S, Saruwatari K, Sato R, Iyama S, Jodai T, Akaike K, Ishizuka S, Saeki S, Sakagami T.	Cancer Immunol Res	10.1158/2326-6066.cir-20-0051	2020
	Characterization of Argonaute Nuclease from Mesophilic Bacterium Chroococcidiopsis.	Peng Y, Zhang Y, Liu Y, Ma L.	Int J Mol Sci	10.3390/ijms26031085	2025
	Effects of Prebiotics and Probiotics on Symptoms of Depression and Anxiety in Clinically Diagnosed Samples: Systematic Review and Meta-analysis of Randomized Controlled Trials.	Asad A, Kirk M, Zhu S, Dong X, Gao M.	Nutr Rev	10.1093/nutrit/nuae177	2025
	Clostridium butyricum improves cognitive dysfunction in ICV-STZ-induced Alzheimer's disease mice via suppressing TLR4 signaling pathway through the gut-brain axis.	Su Y, Wang D, Liu N, Yang J, Sun R, Zhang Z, Zhang Z.	PLoS One	10.1371/journal.pone.0286086	2023
Metabolism	A robust soft sensor to monitor 1,3-propanediol fermentation process by Clostridium butyricum based on artificial neural network.	Zhang AH, Zhu KY, Zhuang XY, Liao LX, Huang SY, Yao CY, Fang BS.	Biotechnol Bioeng	10.1002/bit.27507	2020
Phylogeny	Multi-omics analyses reveal bacteria and catalase associated with keloid disease.	Shan M, Xiao M, Xu J, Sun W, Wang Z, Du W, Liu X, Nie M, Wang X, Liang Z, Liu H, Hao Y, Xia Y, Zhu L, Song K, Feng C, Meng T, Wang Z, Cao W, Wang L, Zheng Z, Wang Y, Huang Y.	EBioMedicine	10.1016/j.ebiom.2023.104904	2024
	Combination of thalidomide and Clostridium butyricum relieves chemotherapy-induced nausea and vomiting via gut microbiota and vagus nerve activity modulation.	Zhao X, Wu H, Zhu R, Shang G, Wei J, Shang H, Tian P, Chen T, Wei H.	Front Immunol	10.3389/fimmu.2023.1220165	2023
	Establishment and validation of a simple and accurate qPCR detection method for Haemophilus parasuis.	Jin H, Xiao X, Wang J, Wang Z, Wei S, Dong C, Zhang Y, Kang C, Sun Y.	Sci Rep	10.1038/s41598-025-92803-1	2025
	Multi-Omics Insights into the Impact of Fermented Wheat Bran-Soybean Meal-Broussonetia papyrifera Mixture Substance on the Gut Microbiota of Late Gestation Sows In Vitro.	Fu L, Chen Y, Li Y, Wang C.	Animals (Basel)	10.3390/ani15213199	2025
	Food colorant brilliant blue causes persistent functional and structural changes in an in vitro simplified microbiota model system.	Castaneda-Monsalve V, Haange SB, Frohlich LF, Fu Q, Rolle-Kampczyk U, von Bergen M, Jehmlich N.	ISME Commun	10.1093/ismeco/ycaf050	2025
	Influences of Oral Administration of Probiotics on Posthepatectomy Recovery in Patients in Child-Pugh Grade.	Huang H, Fang F, Jia Z, Peng W, Wu Y.	Comput Math Methods Med	10.1155/2022/2942982	2022
Metabolism	Seasonal shift of the gut microbiome synchronizes host peripheral circadian rhythm for physiological adaptation to a low-fat diet in the giant panda.	Huang G, Wang L, Li J, Hou R, Wang M, Wang Z, Qu Q, Zhou W, Nie Y, Hu Y, Ma Y, Yan L, Wei H, Wei F.	Cell Rep	10.1016/j.celrep.2021.110203	2022
	The Canadian Network for Mood and Anxiety Treatments Task Force Recommendations for the Use of Probiotics, Prebiotics, Synbiotics, and Fecal Microbiota Transplants in Adults With Major Depressive Disorder: Recommandations du Groupe de travail du Réseau canadien pour le traitement des troubles de l'humeur et de l'anxiété (Canadian Network for Mood and Anxiety Treatments, CANMAT) concernant l'utilisation des probiotiques, des prébiotiques, des symbiotiques et de la transplantation de microbiote fécal chez les adultes atteints de trouble dépressif majeur.	Bahji A, Brietzke E, Cooke NCA, Clement F, Frey BN, Hofmeister M, Kennedy SH, Lam R, Milev R, Moinul D, Parikh SV, Patten S, Ravindran A, Rosenblat JD, Samaan Z, Schaffer A, Saleem A, Beaulieu S, Tourjman V, Van Ameringen M, Vigod S, Yatham L, Taylor V, Canadian Network for Mood and Anxiety Treatments (CANMAT) Taskforce.	Can J Psychiatry	10.1177/07067437251394363	2025
	Probiotic supplementation regulated swine growth performance, fecal odor reduction and carcass characteristics by modulating intestinal microbiome.	Chen YT, Sun YT, Lee HF, Lin YC, Chen MJ.	Anim Microbiome	10.1186/s42523-025-00441-9	2025
	Efficacy of probiotics in the treatment of minimal hepatic encephalopathy: A systematic review and meta-analysis.	Wibawa IDN, Mariadi IK, Shalim CP, Sindhughosa DA.	Clin Exp Hepatol	10.5114/ceh.2023.128768	2023
Phenotype	Investigating the correlation between phenotype, cecal microbiome, and serum metabolome in laying ducks with different shell strength.	Sun H, Hu Z, Li Z, Xiong X, Gu T, Xu W, Chen L, Tian Y, Li G, Zeng T, Lu L, Shi F.	Poult Sci	10.1016/j.psj.2025.105558	2025
Enzymology	Variation in Intramuscular Fat Deposition of Goats and Sheep and Its Correlation with Gut Microbiota.	Yang L, Li S, Hou J, Tang Z, Shi B, Luo Y, Wang J, Zhao F.	Foods	10.3390/foods14111885	2025
	Clostridium butyricum modulates gut microbiota and reduces colitis associated colon cancer in mice.	Liu M, Xie W, Wan X, Deng T.	Int Immunopharmacol	10.1016/j.intimp.2020.106862	2020
Pathogenicity	Probiotics Exert Protective Effect against Sepsis-Induced Cognitive Impairment by Reversing Gut Microbiota Abnormalities.	Liu J, Jin Y, Li H, Yu J, Gong T, Gao X, Sun J.	J Agric Food Chem	10.1021/acs.jafc.0c06332	2020
	Role of probiotic extracellular vesicles in inter-kingdom communication and current technical limitations in advancing their therapeutic utility.	Sanwlani R, Bramich K, Mathivanan S.	Extracell Vesicles Circ Nucl Acids	10.20517/evcna.2024.39	2024
	The Draft Genome Sequence of Clostridium butyricum QXYZ514, a Potent Bacterium for Converting Glycerol into Fuels and Bioproducts in the Waste-Based Biorefinery.	Yang M, Zabed HM, Yun J, Zhang G, Qi X.	Curr Microbiol	10.1007/s00284-020-02182-1	2020
	The metagenomic and metabolomic profile of the gut microbes in Chinese full-term and late preterm infants treated with Clostridium butyricum.	Li H, Ma X, Li Y, Liu Q, Tian Q, Yang X, Zhou Z, Ren J, Sun B, Feng X, Zhang H, Yin X, Li H, Ding X.	Sci Rep	10.1038/s41598-023-45586-2	2023
	Identification and Characterization of a Potential Probiotic, Clostridium butyricum G13, Isolated from the Intestine of the Mud Crab (Scylla paramamosain).	Liang H, Tran NT, Deng T, Li J, Lei Y, Bakky MAH, Zhang M, Li R, Chen W, Zhang Y, Chen X, Li S.	Microbiol Spectr	10.1128/spectrum.01317-23	2023
	Clostridium butyricum as probiotic for promoting growth performance, feed utilization, gut health and microbiota community of tilapia (Oreochromis niloticus × O. aureus)	Poolsawat L, Li X, He M, Ji D, Leng X.	Aquaculture nutrition.	10.1111/anu.13025	2020
	Next generation probiotics for human health: An emerging perspective.	Jan T, Negi R, Sharma B, Kumar S, Singh S, Rai AK, Shreaz S, Rustagi S, Chaudhary N, Kaur T, Kour D, Sheikh MA, Kumar K, Yadav AN, Ahmed N.	Heliyon	10.1016/j.heliyon.2024.e35980	2024
Phylogeny	Gut microbiota characteristics in neonatal respiratory distress syndrome and the therapeutic potential of probiotics in recovery.	Fu Y, Wang X, Nie L, Wang Z, Ma X, Wu L, Han L, Fu W, Wang R, Ren H, Zhang D, Ding J.	Front Microbiol	10.3389/fmicb.2025.1544055	2025
	Clostridium butyricum improves the intestinal health of goats by regulating the intestinal microbial community.	Zhang C, Hou T, Yu Q, Wang J, Ni M, Zi Y, Xin H, Zhang Y, Sun Y.	Front Microbiol	10.3389/fmicb.2022.991266	2022
	Beneficial Probiotics with New Cancer Therapies for Improved Treatment of Hepatocellular Carcinoma.	Nakashima M, Fukumoto A, Matsuda S.	Diseases	10.3390/diseases13040111	2025
	Salivary microbiome in patients with benign prostatic hyperplasia: altered composition and its association with prostate-specific antigen.	Zhang B, Guo H, Li Z, Lin H, Zhi J, Tang Y, Sun Y, Xia Q, Wang S, Jiang P, Gu C, Wei S, Zhao Y, Li Z, Guo W, Gu Y, Gao F, Liu F, Wu Y, Feng N, Xu Z, Chen W.	BMC Microbiol	10.1186/s12866-025-04444-z	2025
Pathogenicity	Optimization of pH conditions to improve the spore production of Clostridium butyricum NN-2 during fermentation process.	Li S, Zhang X, Li Y, Tao L, Li T.	Arch Microbiol	10.1007/s00203-020-01820-3	2020
Pathogenicity	Features of the First Case of Foodborne Botulism Caused by Dual-Toxin Clostridium parabotulinum Subtype A1(B5) in Spain.	Valdezate S, Valiente M, Carrasco G, Medina-Pascual MJ, Hurtado MI, de Pipaon MR, Garrido N, Paradas C, Hernandez-Bello JR, Villalon P.	Toxins (Basel)	10.3390/toxins17090429	2025
Enzymology	Establishment and evaluation of a method for efficient screening of Clostridium butyricum.	Yi Z, Sadiq FA, Wang H, Zhao J, Zhang H, Lu W, Chen W.	Folia Microbiol (Praha)	10.1007/s12223-020-00803-7	2020
	Effects of dietary Clostridium butyricum and fructooligosaccharides, alone or in combination, on performance, egg quality, amino acid digestibility, jejunal morphology, immune function, and antioxidant capacity of laying hens.	Obianwuna UE, Qiu K, Wang J, Wang J, Zhang HJ, Qi GH, Huang LL, Wu SG.	Front Microbiol	10.3389/fmicb.2023.1125897	2023
Pathogenicity	Amelioration of non-alcoholic fatty liver disease by sodium butyrate is linked to the modulation of intestinal tight junctions in db/db mice.	Yang T, Yang H, Heng C, Wang H, Chen S, Hu Y, Jiang Z, Yu Q, Wang Z, Qian S, Wang J, Wang T, Du L, Lu Q, Yin X.	Food Funct	10.1039/d0fo01954b	2020
	The Impact of Allicin on the Growth of Clostridium spp. in the Digestive Track of Quails.	Makuch A, Ziomek M, Sapala M, Drabik K, Batkowska J, Domaradzki P, Patyra E, Grenda T.	Animals (Basel)	10.3390/ani15070906	2025
	Effects of prebiotic and multispecies probiotic supplementation on the gut microbiota, immune function, and growth performance of weaned piglets.	Huaman SOB, de Souza FA, Bonato MA, Dias CP, Callegari MA, Oba A, de Carvalho RH, da Silva CA.	PLoS One	10.1371/journal.pone.0313475	2024
	Aerosol Inhalation of Heat-Killed Clostridium butyricum CGMCC0313-1 Alleviates Allergic Airway Inflammation in Mice.	Li L, Sun Q, Xiao H, Zhang Q, Xu S, Lai L, Li Z, Li C.	J Immunol Res	10.1155/2022/8447603	2022
Metabolism	Antimicrobial and antibiofilm activities of Clostridium butyricum supernatant against Acinetobacter baumannii.	Shin DS, Eom YB.	Arch Microbiol	10.1007/s00203-020-01823-0	2020
	Pneumocystis Pneumonia in Locally Advanced Breast Cancer Despite Prophylactic Use of Trimethoprim-Sulfamethoxazole During Prednisolone Treatment for a Pembrolizumab-Induced Immune-Related Adverse Event: A Case Report.	Kaneda Y, Gonda K, Asakura T, Wada M, Sawano T, Kurokawa T, Tachibana K, Ozaki A.	Cureus	10.7759/cureus.56868	2024
Pathogenicity	Protective Effects of Clostridium Butyricum in a Murine Model of Dextran Sodium Sulfate-Induced Colitis That Involve Inhibition of the TLR2 Signaling Pathway and T Helper 17 Cells.	Xie Y, Zhou L, Yao X, Li Y.	Am J Med Sci	10.1016/j.amjms.2020.05.021	2020
	MALDI-TOF Mass Spectrometry and 16S rRNA Gene Sequence Analysis for the Identification of Foodborne Clostridium Spp.	Sulaiman IM, Miranda N, Simpson S.	J AOAC Int	10.1093/jaoacint/qsab070	2021
	The synergistic effect of herbal medicine and probiotics in pediatric functional constipation: A systematic review and meta-analysis.	Kim E, Chang S, Nam J, Park N, Min SY.	Medicine (Baltimore)	10.1097/md.0000000000036899	2024
	Literature review of the clinical features of sulfasalazine-induced drug reaction with eosinophilia and systemic symptoms/drug-induced hypersensitivity syndrome (DRESS/DIHS).	Liu Y, Wang D, Wu S, Liu X, Xiao C.	Front Pharmacol	10.3389/fphar.2024.1488483	2024
	Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery.	Xu J, Dai D, Yang Y, Gao S, Yang J, Dong C, Yang W, Yuan J, Wang T, Tian T, Yang Y, Luo F, Jiang P, Wu C, Sun X, Sui Y, Gao G, Ma W, Wu Y, Zhang J, Li J, Guo C, Cui C, Guo T, Zhao X, Yuan J, Qiao S, Hu F, Gao X, Luo X, Peng H, Wang D, Wu J, Wu C, He J, Chen WH, Yang Y, Fu J.	Imeta	10.1002/imt2.70079	2025
	Dietary Bacillus toyonensis BCT-7112^T Supplementation Influences Performance, Egg Quality, Ammonia Emission, and Cecal Microbiome in Laying Ducks.	Incharoen T, Charoensook R, Tartrakoon W, Numthuam S, Sunanta Y, Jimenez G, Loor JJ.	Vet Sci	10.3390/vetsci12030259	2025
	Possible Efficacy of Vedolizumab, an Anti-alpha4beta7 Integrin Antibody, in Palmoplantar Pustulosis.	Terui H, Moroi R, Masamune A, Aiba S, Yamasaki K.	Case Rep Dermatol	10.1159/000529080	2023
	Effect of shear velocity on dark fermentation for biohydrogen production using dynamic membrane.	Sim YB, Jung JH, Park JH, Bakonyi P, Kim SH.	Bioresour Technol	10.1016/j.biortech.2020.123265	2020
	The role of probiotics, prebiotics, and synbiotics in the treatment of inflammatory bowel diseases: an overview of recent clinical trials	Yassine F, Najm A, Bilen M.	Front Syst Biol		2025
	Living Bacteria-Based Immuno-Photodynamic Therapy: Metabolic Labeling of Clostridium butyricum for Eradicating Malignant Melanoma.	Shi L, Liu X, Li Y, Li S, Wu W, Gao X, Liu B.	Adv Sci (Weinh)	10.1002/advs.202105807	2022
	Effects of exogenous probiotics on the gut microbiota and clinical outcomes in critically ill patients: a randomized controlled trial.	Wang J, Ke H, Liu KX, Qu JM.	Ann Palliat Med	10.21037/apm-20-202	2021
Metabolism	Supplemental Clostridium butyricum modulates lipid metabolism by reshaping the gut microbiota composition and bile acid profile in IUGR suckling piglets.	Zhang X, Yun Y, Lai Z, Ji S, Yu G, Xie Z, Zhang H, Zhong X, Wang T, Zhang L.	J Anim Sci Biotechnol	10.1186/s40104-023-00828-1	2023
Pathogenicity	Clostridium butyricum inhibits the inflammation in children with primary nephrotic syndrome by regulating Th17/Tregs balance via gut-kidney axis.	Li T, Ma X, Wang T, Tian W, Liu J, Shen W, Liu Y, Li Y, Zhang X, Ma J, Zhang X, Ma J, Wang H.	BMC Microbiol	10.1186/s12866-024-03242-3	2024
	Crosstalk between gut microbiotas and fatty acid metabolism in colorectal cancer.	Zhang H, Tian Y, Xu C, Chen M, Xiang Z, Gu L, Xue H, Xu Q.	Cell Death Discov	10.1038/s41420-025-02364-5	2025
Metabolism	Bacteria producing antimicrobials against Clostridium difficile isolated from human stool.	Khattab RA, Ahmed NA, Ragab YM, Rasmy SA.	Anaerobe	10.1016/j.anaerobe.2020.102206	2020
	Clostridium butyricum Improves Rumen Fermentation and Growth Performance of Heat-Stressed Goats In Vitro and In Vivo.	Cai L, Hartanto R, Zhang J, Qi D.	Animals (Basel)	10.3390/ani11113261	2021
	Clostridium butyricum Can Promote Bone Development by Regulating Lymphocyte Function in Layer Pullets.	Song M, Zhang X, Hao G, Lin H, Sun S.	Int J Mol Sci	10.3390/ijms24021457	2023
	Enhancing egg production and quality by the supplementation of probiotic strains (Clostridium and Brevibacillus) via improved amino acid digestibility, intestinal health, immune response, and antioxidant activity.	Obianwuna UE, Qiu K, Chang XY, Zhang HJ, Wang J, Wang J, Qi GH, Sun TH, Su YB, Wu SG.	Front Microbiol	10.3389/fmicb.2022.987241	2022
	Effects of Clostridium butyricum on production performance and intestinal absorption function of laying hens in the late phase of production	Wang W, Wang J, Zhang Hj, Wu Sg, Qi Gh.	Anim Feed Sci Technol	10.1016/j.anifeedsci.2020.114476	2020
	Colon-specific controlled release of oral liposomes for enhanced chemo-immunotherapy against colorectal cancer.	Niu M, Pei Y, Jin T, Li J, Bai L, Zheng C, Song Q, Zhao H, Zhang Y, Wang L.	Acta Pharm Sin B	10.1016/j.apsb.2024.09.015	2024
	Remdesivir-induced severe hypoglycemia in an elderly man without diabetes: a case report.	Nagano Y, Aoki H, David J, Kondo NI, Aizawa M, Sumita T, Hamada Y, Yamamoto Y, Yamada K.	J Pharm Health Care Sci	10.1186/s40780-024-00406-1	2025
	Effects of Tetrabasic Zinc Chloride as Alternative to High Doses of Zinc Oxide on Growth Performance, Nutrient Digestibility, Intestinal Morphology, Immune Function, and Gut Microbiota in Weaned Piglets.	Peng S, Fang J, Zhang N, Chen Y, Ma Y, Wang C.	Animals (Basel)	10.3390/ani15213071	2025
	Microbial community and organic compounds composition analysis and the edible security of common buckwheat fermented via Kombucha consortium.	Al-Wraikat M, Abubaker MA, Liu Y, Shen X, He Y, Li L, Liu Y.	Food Chem (Oxf)	10.1016/j.fochms.2025.100247	2025
	Comparison of mesophilic and thermophilic dark fermentation with nickel ferrite nanoparticles supplementation for biohydrogen production.	Zhang J, Zhao W, Yang J, Li Z, Zhang J, Zang L.	Bioresour Technol	10.1016/j.biortech.2021.124853	2021
	The Significance of Probiotics in Aquaculture: A Review of Research Trend and Latest Scientific Findings.	Mohammed EAH, Ahmed AEM, Kovacs B, Pal K.	Antibiotics (Basel)	10.3390/antibiotics14030242	2025
	Unveiling the Gastrointestinal Microbiome Symphony: Insights Into Post-Gastric Cancer Treatment Microbial Patterns and Potential Therapeutic Avenues.	Park CH.	J Gastric Cancer	10.5230/jgc.2024.24.e4	2024
Pathogenicity	Dietary Clostridium butyricum supplementation modifies significantly the liver transcriptomic profile in weaned piglets.	Qiao J, Li H, Li Y.	J Anim Physiol Anim Nutr (Berl)	10.1111/jpn.13326	2020
	Bi-Directional Relationship Between Bile Acids (BAs) and Gut Microbiota (GM): UDCA/TUDCA, Probiotics, and Dietary Interventions in Elderly People.	Francini E, Badillo Pazmay GV, Fumarola S, Procopio AD, Olivieri F, Marchegiani F.	Int J Mol Sci	10.3390/ijms26041759	2025
	Combined Supplementation of Clostridium butyricum and Bifidobacterium infantis Diminishes Chronic Unpredictable Mild Stress-Induced Intestinal Alterations via Activation of Nrf-2 Signaling Pathway in Rats.	Fatima S, Altwaijry H, Abulmeaty MMA, Abudawood M, Siddiqi NJ, Alrashoudi RH, Alsobaie S.	Int J Mol Sci	10.3390/ijms24098264	2023
Enzymology	Neonatal necrotizing enterocolitis: Clostridium butyricum and Clostridium neonatale fermentation metabolism and enteropathogenicity.	Ferraris L, Balvay A, Bellet D, Delannoy J, Maudet C, Larcher T, Roze JC, Philippe C, Meylheuc T, Butel MJ, Rabot S, Aires J.	Gut Microbes	10.1080/19490976.2023.2172666	2023
Genetics	Tracing and characterization of foodborne botulism caused by the new MLST type Clostridium botulinum A2 in Hebei province, China.	Lu Z, Feng J, Luo X, Sun H, Huang Y, Lu S, Wang D, Xu X, Lu X, Xu L.	Front Microbiol	10.3389/fmicb.2025.1567360	2025
	Combined effects of emodin and Clostridium butyricum on growth and non-specific immunity of giant freshwater prawns, Macrobrachium rosenbergii	Tadese DA, Sun C, Liu B, Muritu RW, Kevin NT, Zhou Q, Zhu L, Zhang H, Bo L, Liu M, Xu H.	Aquaculture	10.1016/j.aquaculture.2020.735281	2020
Metabolism	DNA targeting and interference by a bacterial Argonaute nuclease.	Kuzmenko A, Oguienko A, Esyunina D, Yudin D, Petrova M, Kudinova A, Maslova O, Ninova M, Ryazansky S, Leach D, Aravin AA, Kulbachinskiy A.	Nature	10.1038/s41586-020-2605-1	2020
	Enterococcal autoprobiotics in the complex treatment of colorectal cancer patient receiving chemotherapy: Two case reports and review of literature.	Ermolenko EI, Baryshnikova NV, Kovalis SA, Novilova NS, Orlova VV, Ilyina AS, Kashchenko VA, Leontieva GF, Suvorov AN.	World J Clin Cases	10.12998/wjcc.v13.i27.107704	2025
	Impact of Phosphogypsum on Viability of Trichuris suis Eggs in Anaerobic Digestion of Swine Manure.	Boyko O, Brygadyrenko V, Chernysh Y, Chubur V, Roubik H.	Microorganisms	10.3390/microorganisms13051165	2025
	A Case of Type 1 Diabetes Mellitus With Intractable Chronic Diarrhea and Challenging Glycemic Control.	Yamada SM, Takada H, Harada T, Terada S, Nehashi Y, Mori N.	Cureus	10.7759/cureus.72070	2024
	Dietary Supplementation with Bacillus licheniformis and Bacillus subtilis Modulates Immunity, Serum Metabolome, and Intestinal Homeostasis in Cats.	Zhang M, Xu H, Zhang T, Kang J, Xu Z, Wu P, Niu Y, Shi Y, Zhong Y, Yang C.	Animals (Basel)	10.3390/ani15202971	2025
Metabolism	Remodeling gut microbiota by Clostridium butyricum (C.butyricum) attenuates intestinal injury in burned mice.	Zhang D, Zhu C, Fang Z, Zhang H, Yang J, Tao K, Hu D, Han J, Yang X.	Burns	10.1016/j.burns.2020.01.007	2020
	Stachyose attenuates DSS-induced colitis and is associated with elevated colonic medium-chain fatty acids: an integrated multi-omics analysis.	Kim G, Chen K, Xing Z, Wu X, Zhang H, Fang Y, Zhang Z, He N, Li S, Zhang F.	NPJ Sci Food	10.1038/s41538-025-00604-7	2025
	The novel immunobiotic Clostridium butyricum S-45-5 displays broad-spectrum antiviral activity in vitro and in vivo by inducing immune modulation.	Chathuranga K, Shin Y, Uddin MB, Paek J, Chathuranga WAG, Seong Y, Bai L, Kim H, Shin JH, Chang YH, Lee JS.	Front Immunol	10.3389/fimmu.2023.1242183	2023
	Dietary galactosyl and mannosyl carbohydrates: In-vitro assessment of prebiotic effects.	Wei X, Fu X, Xiao M, Liu Z, Zhang L, Mou H.	Food Chem	10.1016/j.foodchem.2020.127179	2020
Metabolism	Characterizing Different Probiotic-Derived Extracellular Vesicles as a Novel Adjuvant for Immunotherapy.	Morishita M, Horita M, Higuchi A, Marui M, Katsumi H, Yamamoto A.	Mol Pharm	10.1021/acs.molpharmaceut.0c01011	2021
	Therapeutic Prospect of New Probiotics in Neurodegenerative Diseases.	Bi M, Liu C, Wang Y, Liu SJ.	Microorganisms	10.3390/microorganisms11061527	2023
	The gut microbiome and cancer response to immune checkpoint inhibitors.	Gazzaniga FS, Kasper DL.	J Clin Invest	10.1172/jci184321	2025
	Occurrence of Neonatal Necrotizing Enterocolitis in Premature Neonates and Gut Microbiota: A Case-Control Prospective Multicenter Study.	Aires J, Ilhan ZE, Nicolas L, Ferraris L, Delannoy J, Bredel M, Chauvire-Drouard A, Barbut F, Roze JC, Lepage P, Butel MJ, ClosNEC Study Group.	Microorganisms	10.3390/microorganisms11102457	2023
Metabolism	Effect of Clostridium butyricum against Microglia-Mediated Neuroinflammation in Alzheimer's Disease via Regulating Gut Microbiota and Metabolites Butyrate.	Sun J, Xu J, Yang B, Chen K, Kong Y, Fang N, Gong T, Wang F, Ling Z, Liu J.	Mol Nutr Food Res	10.1002/mnfr.201900636	2020
	Pretreatment with an antibiotics cocktail enhances the protective effect of probiotics by regulating SCFA metabolism and Th1/Th2/Th17 cell immune responses.	Xu J, Xu H, Guo X, Zhao H, Wang J, Li J, He J, Huang H, Huang C, Zhao C, Li Y, Zhou Y, Peng Y, Nie Y.	BMC Microbiol	10.1186/s12866-024-03251-2	2024
	Synergistic anti-tumour effects of Clostridium butyricum in combination with apatinib in CT26 colorectal tumour-bearing mice.	Xin M, Xie Q, Ma L, An G, Xiao J, Li J, Liu X, Gao P, Liang J, Li Y.	Anticancer Drugs	10.1097/cad.0000000000000817	2019
	Dietary RISCO NUTRIFOUR multistrain multikingdom probiotic consortia improves meat quality carcass traits and growth efficiency in heat stressed broilers.	Al-Abdullatif AA, Al-Garadi MA, Qaid MM, Matar AM, Alobre MM, Al-Badwi MA, Suliman GM, Hussein EO.	Sci Rep	10.1038/s41598-025-17988-x	2025
Phylogeny	Multi-Omics Analysis of Gut Microbiota and Sperm Quality in Tibetan Breeding Boars.	Zhao M, Han M, Zhang H, Wang X, Yin Y, Zhang J, Shang P.	Metabolites	10.3390/metabo15070447	2025
	Clostridium butyricum Reduces Obesity in a Butyrate-Independent Way.	Liao J, Liu Y, Pei Z, Wang H, Zhu J, Zhao J, Lu W, Chen W.	Microorganisms	10.3390/microorganisms11051292	2023
	Advancements in gene editing technologies for probiotic-enabled disease therapy.	Wang L, Hu J, Li K, Zhao Y, Zhu M.	iScience	10.1016/j.isci.2024.110791	2024
	A Real-World Perspective of Co-amoxiclav Prescription Pattern With Probiotics for Pediatric Patients With Respiratory Tract Infections: Results of Quantitative and Qualitative Approach in Indian Outpatient Settings.	Choudhury J, Makkar A, Sharma V, Karamath SP, Parmar V, Kumar J P, Veligandla KC, Pinto CS, Mane A, Rathod R, Kotak BP.	Cureus	10.7759/cureus.36269	2023
	Parabacteroides goldsteinii mitigates the lipopolysaccharide-induced inflammatory response in IPEC-J2 cells.	Zhang J, Li A, He Y, Guo T, Ge Y, Pan H, Dong C.	Front Vet Sci	10.3389/fvets.2025.1577126	2025
Metabolism	Effects of Clostridium butyricum and Enterococcus faecalis on growth performance, immune function, intestinal morphology, volatile fatty acids, and intestinal flora in a piglet model.	Wang K, Cao G, Zhang H, Li Q, Yang C.	Food Funct	10.1039/c9fo01650c	2019
	Clostridium butyricum Protects Against Pancreatic and Intestinal Injury After Severe Acute Pancreatitis via Downregulation of MMP9.	Yan Q, Jia L, Wen B, Wu Y, Zeng Y, Wang Q.	Front Pharmacol	10.3389/fphar.2022.919010	2022
	Multiomics-based analysis of the mechanism of ammonia reduction in Sphingomonas.	Mingcheng W, Daoqi L, Huili X, Gailing W, Chaoying L, Yanan G, Aizhen G.	Front Microbiol	10.3389/fmicb.2024.1437056	2024
	The gas production, ruminal fermentation parameters, and microbiota in response to Clostridium butyricum supplementation on in vitro varying with media pH levels.	Zhang M, Liang G, Zhang X, Lu X, Li S, Wang X, Yang W, Yuan Y, Jiao P.	Front Microbiol	10.3389/fmicb.2022.960623	2022
Metabolism	Enhanced reductive dechlorination of trichloroethene with immobilized Clostridium butyricum in silica gel.	Lo KH, Lu CW, Lin WH, Chien CC, Chen SC, Kao CM.	Chemosphere	10.1016/j.chemosphere.2019.124596	2020
	Engineered probiotics Clostridium butyricum-pMTL007-GLP-1 improves blood pressure via producing GLP-1 and modulating gut microbiota in spontaneous hypertension rat models.	Wang XL, Chen WJ, Jin R, Xu X, Wei J, Huang H, Tang YH, Zou CW, Chen TT.	Microb Biotechnol	10.1111/1751-7915.14196	2023
	Construction of a metabolic-immune model for predicting the risk of diabetic nephropathy and study of gut microbiota.	Dai M, Wu J, Ji Z, Chen P, Yang C, Luo J, Shan P, Xu M.	J Diabetes Investig	10.1111/jdi.14401	2025
	Dietary Supplementation with Saccharomyces cerevisiae, Clostridium butyricum and Their Combination Ameliorate Rumen Fermentation and Growth Performance of Heat-Stressed Goats.	Cai L, Yu J, Hartanto R, Qi D.	Animals (Basel)	10.3390/ani11072116	2021
	Clostridium butyricum improves immune responses and remodels the intestinal microbiota of common carp (Cyprinus carpio L.)	Meng X, Wu S, Hu W, Zhu Z, Yang G, Zhang Y, Qin C, Yang L, Nie G.	Aquaculture		2020
	Enhancing laying performance and immunity via probiotic and vitamin additives during induced molting.	Wang C, Xiao S, Yang Z.	Front Vet Sci	10.3389/fvets.2024.1387877	2024
	Clostridium butyricum Prevents Dysbiosis and the Rise in Blood Pressure in Spontaneously Hypertensive Rats.	Luo X, Han Z, Kong Q, Wang Y, Mou H, Duan X.	Int J Mol Sci	10.3390/ijms24054955	2023
	Influence of antibacterial peptides in drinking water on growth and intestinal health of European meat pigeon	Han Y, Liang Y, Luo Y, Cai Y, Lan L, Xu K, Wei B, Shao L, Zhan P, Chang K, Chen X, Wang Z, Wang H, Sun H, Hong P, Liu Z, Wu Z, Chen Y, Zhang X.	Poult Sci		2025
	A Comparative Study on Effects of Three Butyric Acid-Producing Additives on the Growth Performance, Non-specific Immunity, and Intestinal Microbiota of the Sea Cucumber Apostichopus japonicus.	Liu L, Wei C, Li Y, Wang M, Mao Y, Tian X.	Aquac Nutr	10.1155/2024/6973951	2024
	Bidirectional crosstalk between the gut microbiota and cellular compartments of brain: Implications for neurodevelopmental and neuropsychiatric disorders	Jabbari Shiadeh S, Chan W, Rasmusson S, Hassan N, Joca S, Westberg L, Elfvin A, Mallard C, Ardalan M.	Transl Psychiatry		2025
	Optimization of bacteriocin production by Lactobacillus rhamnosus CW40: exploring its therapeutic and antibacterial scope.	Upadhyay P, Verma AK, Joshi H.	Front Med Technol	10.3389/fmedt.2025.1663924	2025
	The effect of probiotics on surgical outcomes in patients with gastric cancer: a meta-analysis of randomized controlled trials.	Ye W, Dong B, Li G, Zhang Y.	Front Surg	10.3389/fsurg.2023.1254597	2023
	Immunoregulatory role of pulmonary microbiota in lung cancer: a bibliometric analysis.	Jia H, Gong Y, Wei H, Zhao C, Zang Q, Liew CSL.	Discov Oncol	10.1007/s12672-025-02595-z	2025
	Immunoregulatory role of the gut microbiota in inflammatory depression.	Liu P, Liu Z, Wang J, Wang J, Gao M, Zhang Y, Yang C, Zhang A, Li G, Li X, Liu S, Liu L, Sun N, Zhang K.	Nat Commun	10.1038/s41467-024-47273-w	2024
	Dietary Supplementation of Chitosan Oligosaccharide-Clostridium butyricum Synbiotic Relieved Early-Weaned Stress by Improving Intestinal Health on Pigeon Squabs (Columba livia).	Wen J, Zhao W, Li J, Hu C, Zou X, Dong X.	Front Immunol	10.3389/fimmu.2022.926162	2022
	Co-fermentation of glycerol and glucose by a co-culture system of engineered Escherichia coli strains for 1,3-propanediol production without vitamin B₁₂ supplementation.	Yun J, Zabed HM, Zhang Y, Parvez A, Zhang G, Qi X.	Bioresour Technol	10.1016/j.biortech.2020.124218	2021
	Effects of Dietary Supplementation With Clostridium butyricum on the Amelioration of Growth Performance, Rumen Fermentation, and Rumen Microbiota of Holstein Heifers.	Li Y, Wang Y, Lv J, Dou X, Zhang Y.	Front Nutr	10.3389/fnut.2021.763700	2021
	Sheep-derived butyrate-producing Clostridium beijerinckii R8 alleviates diarrhea by shaping the gut microbiota of goat kids.	Fan D, Fu Y, Zhang J, Bi Y, Ma T, Diao Q, Zhang N.	Anim Nutr	10.1016/j.aninu.2024.06.004	2024
	Inhibitory effects of Clostridium butyricum culture and supernatant on inflammatory colorectal cancer in mice.	Pu W, Zhang H, Zhang T, Guo X, Wang X, Tang S.	Front Immunol	10.3389/fimmu.2023.1004756	2023
Metabolism	Altered intestinal microbiota in children with bronchiolitis.	Wu XB, Wang J, Tang Y, Jiang J, Li XM.	Front Microbiol	10.3389/fmicb.2023.1197092	2023
	Impact of probiotics use on clinical outcomes of immune checkpoint inhibitors therapy in cancer patients.	Wan L, Wu C, Wu Q, Luo S, Liu J, Xie X.	Cancer Med	10.1002/cam4.4994	2023
	Fanconi syndrome and renal tubular necrosis in patients following ingestion of potentially contaminated red yeast rice supplement: Two case reports.	Yoshikawa Y, Anzai H, Odajima K, Asakawa S, Arai S, Yamazaki O, Tamura Y, Ohashi R, Shibata S, Fujigaki Y.	Physiol Rep	10.14814/phy2.70049	2024
	Neuroprotective effect of engineered Clostridiumbutyricum-pMTL007-GLP-1 on Parkinson's disease mice models via promoting mitophagy.	Wang Y, Chen WJ, Han YY, Xu X, Yang AX, Wei J, Hong DJ, Fang X, Chen TT.	Bioeng Transl Med	10.1002/btm2.10505	2023
	Stability of gut microbiota in non-small cell lung cancer patients during chemoradiotherapy and its association with radiation pneumonitis	Xi Y, Liu F, Dong Y, Wang Z, Zhao Q, Li X, Zhang P, Zheng S, Zhou R, Wu Q, Liu H, Qiu B.	iScience		2025
	Efficacy of Probiotics in the Management of Irritable Bowel Syndrome: A Systematic Review and Meta-Analysis.	Almabruk BA, Bajafar AA, Mohamed AN, Al-Zahrani SA, Albishi NM, Aljarwan R, Aljaser RA, Alghamdi LI, Almutairi TS, Alsolami AS, Alghamdi JK.	Cureus	10.7759/cureus.75954	2024
	Efficacy of probiotics pretreatment in Helicobacter pylori eradication therapy: a systematic review and meta-analysis of clinical outcomes.	Zhang Y, Tu M, Long P, Zheng J, Du G, Xiao S, Gao C.	Ann Med	10.1080/07853890.2025.2533431	2025
	Effects of Clostridium butyricum on intestinal environment and gut microbiome under Salmonella infection.	Zhang X, Song M, Lv P, Hao G, Sun S.	Poult Sci	10.1016/j.psj.2022.102077	2022
	A Combination of Two Probiotics, Lactobacillus sporogenes and Clostridium butyricum, Inhibits Colon Cancer Development: An In Vitro Study.	Budu O, Banciu C, Pinzaru I, Sarau C, Lighezan D, Soica C, Dehelean C, Draghici G, Dolghi A, Prodea A, Mioc M.	Microorganisms	10.3390/microorganisms10091692	2022
	The microbiota-gut- hippocampus axis.	Salami M, Soheili M.	Front Neurosci	10.3389/fnins.2022.1065995	2022
	Effects of Dietary Supplementation With Clostridium butyricum on Growth Performance, Apparent Digestibility, Blood Metabolites, Ruminal Fermentation and Bacterial Communities of Fattening Goats.	Zhang C, Yu Q, Wang J, Yu Y, Zhang Y, Sun Y.	Front Nutr	10.3389/fnut.2022.888191	2022
Phylogeny	Whole-Genome-Sequencing Analysis of the Pathogen Causing Spotting Disease and Molecular Response in the Strongylocentrotus intermedius.	Li S, Tian F, Wang Y, Xiao H, Zhou Z, Cao L, Han L, Sun J, Zhao C, Ding J.	Microorganisms	10.3390/microorganisms13092019	2025
	A Pilot Study: Favorable Effects of Clostridium butyricum on Intestinal Microbiota for Adjuvant Therapy of Lung Cancer.	Cong J, Zhang C, Zhou S, Zhu J, Liang C.	Cancers (Basel)	10.3390/cancers14153599	2022
	Effects of residual feed intake divergence on the productive performance, egg quality, meat quality, and gut microbiome in native chickens.	Wan Y, Ma R, Qi R, Liu W, Li J, Zhou L, Li Y, Li Y, Liu Z, Zhao W, Liu P, Li Y, Zhan K.	Poult Sci	10.1016/j.psj.2025.105788	2025
Pathogenicity	REG/Reg family proteins: mediating gut microbiota homeostasis and implications in digestive diseases.	Qi Z, Pang W, Zha X, Liu Y, Liu S, Xiao F, Wang X, Zhou J, Wang W, Liu X.	Gut Microbes	10.1080/19490976.2025.2568055	2025
Metabolism	Effects of Dietary Clostridium butyricum on the Growth, Digestive Enzyme Activity, Antioxidant Capacity, and Resistance to Nitrite Stress of Penaeus monodon.	Duan Y, Zhang J, Huang J, Jiang S.	Probiotics Antimicrob Proteins	10.1007/s12602-018-9421-z	2019
	Probiotics as Potential Treatments for Neurodegenerative Diseases: a Review of the Evidence from in vivo to Clinical Trial.	Kim JH, Choi Y, Lee S, Oh MS.	Biomol Ther (Seoul)	10.4062/biomolther.2024.215	2025
Pathogenicity	Probiotic Clostridium butyricum Improves the Growth Performance, Immune Function, and Gut Microbiota of Weaning Rex Rabbits.	Liu L, Zeng D, Yang M, Wen B, Lai J, Zhou Y, Sun H, Xiong L, Wang J, Lin Y, Pan K, Jing B, Wang P, Ni X.	Probiotics Antimicrob Proteins	10.1007/s12602-018-9476-x	2019
	Quantitative Alterations in Short-Chain Fatty Acids in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.	Chulenbayeva L, Jarmukhanov Z, Kaliyekova K, Kozhakhmetov S, Kushugulova A.	Biomolecules	10.3390/biom15071017	2025
Pathogenicity	Therapeutic effects of probiotic Clostridium butyricum WZ001 on bacterial vaginosis in mice.	Zhou Y, Xu W, Hong K, Li H, Zhang J, Chen X, Zhu Y, Zhang Q, Ding F, Wang F.	J Appl Microbiol	10.1111/jam.14329	2019
	Clostridium butyricum alleviates dextran sulfate sodium-induced experimental colitis and promotes intestinal lymphatic vessel regeneration in mice.	Chen X, Ma L, Liu X, Wang J, Li Y, Xie Q, Liang J.	Ann Transl Med	10.21037/atm-22-1059	2022
	Intestinal bacteria flora changes in patients with Mycoplasma pneumoniae pneumonia with or without wheezing.	Jiang Y, Bao C, Zhao X, Chen Y, Song Y, Xiao Z.	Sci Rep	10.1038/s41598-022-09700-0	2022
	Chinese Herbal Medicine Compound Microecological Agent (C-MEA) Improves Egg Production Performance in Caged Laying Ducks via Microbiota-Gut-Ovary Axis.	Lu Y, Zhang L, Zhu R, Duan X, Sun G, Jiang Y.	Vet Sci	10.3390/vetsci12090808	2025
Phylogeny	Clostridium butyricum affects nutrition and immunology by modulating gut microbiota.	Yamamoto M, Ohmori H, Takei D, Matsumoto T, Takemoto M, Ikeda M, Sumimoto R, Kobayashi T, Ohdan H.	Biosci Microbiota Food Health	10.12938/bmfh.2021-046	2022
Metabolism	Clostridium butyricum, a butyrate-producing probiotic, inhibits intestinal tumor development through modulating Wnt signaling and gut microbiota.	Chen D, Jin D, Huang S, Wu J, Xu M, Liu T, Dong W, Liu X, Wang S, Zhong W, Liu Y, Jiang R, Piao M, Wang B, Cao H.	Cancer Lett	10.1016/j.canlet.2019.11.019	2020
Pathogenicity	Prebiotics-Encapsulated Probiotic Spores Regulate Gut Microbiota and Suppress Colon Cancer.	Zheng DW, Li RQ, An JX, Xie TQ, Han ZY, Xu R, Fang Y, Zhang XZ.	Adv Mater	10.1002/adma.202004529	2020
	Dietary yucca extract and Clostridium butyricum promote growth performance of weaned rabbits by improving nutrient digestibility, intestinal development, and microbial composition.	Wang Y, Zhang Y, Ren H, Fan Z, Yang X, Zhang C, Jiang Y.	Front Vet Sci	10.3389/fvets.2023.1088219	2023
	Oral Administration of Clostridium butyricum GKB7 Ameliorates Signs of Osteoarthritis in Rats.	Chang SL, Lin YY, Liu SC, Tsai YS, Lin SW, Chen YL, Chen CC, Ko CY, Chen HT, Chen WC, Tang CH.	Cells	10.3390/cells11142169	2022
Pathogenicity	The impact of probiotic Clostridium butyricum MIYAIRI 588 on murine gut metabolic alterations.	Hagihara M, Yamashita R, Matsumoto A, Mori T, Inagaki T, Nonogaki T, Kuroki Y, Higashi S, Oka K, Takahashi M, Mikamo H.	J Infect Chemother	10.1016/j.jiac.2019.02.008	2019
	Effect of Probiotics Supplementation on REM Sleep Behavior Disorder and Motor Symptoms in Parkinson's Disease: A Pilot Study.	Du Y, Wang L, Cui Y, Xu X, Zhang M, Li Y, Gao T, Gao D, Sheng Z, Wang S, Tuo H.	CNS Neurosci Ther	10.1111/cns.70541	2025
	Potential relationship between gut microbiota and animal diarrhea: a systematic review.	Zhang Y, Ma Y, Qi Y.	Front Microbiol	10.3389/fmicb.2025.1637331	2025
	Dietary Clostridium butyricum and Bacillus subtilis Promote Goose Growth by Improving Intestinal Structure and Function, Antioxidative Capacity and Microbial Composition.	Yu J, Dong B, Zhao M, Liu L, Geng T, Gong D, Wang J.	Animals (Basel)	10.3390/ani11113174	2021
Genetics	Alterations in the intestinal microbiome and metabolic profile of patients with cirrhosis supplemented with lactulose, Clostridium butyricum, and Bifidobacterium longum infantis: a randomized placebo-controlled trial.	Lu H, Zhu X, Wu L, Lou X, Pan X, Liu B, Zhang H, Zhu L, Li L, Wu Z.	Front Microbiol	10.3389/fmicb.2023.1169811	2023
	Strategies to Maximize the Benefits of Evidence-Based Enteral Nutrition: A Narrative Review.	Kano KI, Yamamoto R, Yoshida M, Sato T, Nishita Y, Ito J, Nagatomo K, Ohbe H, Takahashi K, Kaku M, Sakuramoto H, Nakanishi N, Inoue K, Hatakeyama J, Kasuya H, Hayashi M, Tsunemitsu T, Tatsumi H, Higashibeppu N, Nakamura K.	Nutrients	10.3390/nu17050845	2025
	The Majority of Bacillus subtilis Strains Isolated From Blood Cultures Were Derived From Traditional Japanese Fermented Soybeans Natto: A Single-center Retrospective Study.	Sada RM, Yamamoto G, Hamaguchi S, Kuroda E, Okura A, Cai M, Nakanishi K, Abe N, Yamamoto S, Kutsuna S.	Open Forum Infect Dis	10.1093/ofid/ofaf574	2025
	Effect of feeding protected sodium butyrate on production performance and intestinal morphology of broilers: A meta-analysis.	Kihal A, Puyalto M, Mallo JJ.	Poult Sci	10.1016/j.psj.2025.105683	2025
	Irritable Bowel Syndrome in Inflammatory Bowel Disease Patients: Prevalence, Etiology, and Treatment.	Gracie DJ, Ford AC.	Gastroenterol Hepatol (N Y)		2025
Phylogeny	Single and Combined Effects of Clostridium butyricum and Coccidiosis Vaccine on Growth Performance and the Intestinal Microbiome of Broiler Chickens.	Cai H, Liao S, Li J, Liu Q, Luo S, Lv M, Lin X, Hu J, Zhang J, Qi N, Sun M.	Front Microbiol	10.3389/fmicb.2022.811428	2022
	Traditional Chinese herbal formulas modulate gut microbiome and improve insomnia in patients with distinct syndrome types: insights from an interventional clinical study.	Zeng H, Xu J, Zheng L, Zhan Z, Fang Z, Li Y, Zhao C, Xiao R, Zheng Z, Li Y, Yang L.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1395267	2024
	Alteration of gut microbiome and metabolome by Clostridium butyricum can repair the intestinal dysbiosis caused by antibiotics in mice.	Liu X, Qiu X, Yang Y, Wang J, Wang Q, Liu J, Yang F, Liu Z, Qi R.	iScience	10.1016/j.isci.2023.106190	2023
	Characteristics and function of the gut microbiota in patients with rectal neuroendocrine tumors.	Gao Y, Zheng H, Ye M, Zhou G, Chen J, Qiang X, Bai J, Lu X, Tang Q.	J Cancer	10.7150/jca.103297	2025
	Acute effects of butyrate on intestinal permeability in patients with irritable bowel syndrome assessed by a novel colonoscopy research model	Scharf M, Forsgard R, Prado S, Ganda Mall J, Repsilber D, Brummer R, Marques T, Wall R.	Gut microbes		2025
	The Role of the Gut Microbiota in Individuals with Irritable Bowel Syndrome: A Scoping Review.	Nagamine T.	Medicina (Kaunas)	10.3390/medicina60111895	2024
Pathogenicity	Clostridium butyricum miyairi 588 has preventive effects on chronic social defeat stress-induced depressive-like behaviour and modulates microglial activation in mice.	Tian T, Xu B, Qin Y, Fan L, Chen J, Zheng P, Gong X, Wang H, Bai M, Pu J, Lu J, Zhou W, Zhao L, Yang D, Xie P.	Biochem Biophys Res Commun	10.1016/j.bbrc.2019.06.053	2019
	Dietary Fermented Chicory Root Waste Modulates Growth, Chemical Composition, Lipid Metabolism, and Intestinal Barrier Pathways in Common Carp (Cyprinus carpio L.) Fed With High-Fat Diets.	Gu J, Tian X, Wang T, An S, Yang B, Huang Z, Chang X, Yang G, Feng S, Zhang X, Zhang Y, Naiel MAE, Meng X.	Aquac Nutr	10.1155/anu/2234393	2025
Metabolism	Granular activated carbon supplementation alters the metabolic flux of Clostridium butyricum for enhanced biohydrogen production.	Park JH, Kim DH, Kim HS, Wells GF, Park HD.	Bioresour Technol	10.1016/j.biortech.2019.02.090	2019
	Random guide-independent DNA cleavage from the Argonaute of Exiguobacterium sp. AB2.	Caniza MAM, Dy RLV.	BMC Microbiol	10.1186/s12866-025-04159-1	2025
	Protective effect of Clostridium butyricum against Carassius auratus herpesvirus in gibel carp	Li T, Ke F, Gui JF, Zhou L, Zhang XJ, Zhang QY.	Aquac Int	10.1007/s10499-019-00377-3	2019
Metabolism	Random mutagenesis of Clostridium butyricum strain and optimization of biosynthesis process for enhanced production of 1,3-propanediol.	Yang M, An Y, Zabed HM, Guo Q, Yun J, Zhang G, Awad FN, Sun W, Qi X.	Bioresour Technol	10.1016/j.biortech.2019.03.098	2019
	Temporary Severe Neutropenia during Administration of Atezolizumab: A Novel Case Report.	Kanno R, Saito Y, Takekuma Y, Asahina H, Sugawara M.	Case Rep Oncol	10.1159/000530338	2023
	Inkjet-printed colorimetric indicators from the peels of red pitaya and Kyoho grape for the detection of food spoilage gases.	Gong T, Luo X.	Curr Res Food Sci	10.1016/j.crfs.2025.101064	2025
	Sodium butyrate promotes synthesis of testosterone and meiosis of hyperuricemic male mice.	Qi J, Sun Y, Chen Z, Gao R, Song M, Zou T, Gong X, Wang S, Zhang Q, Liu C, Xing S.	Sci Rep	10.1038/s41598-025-95846-6	2025
	Vaccination and Microbiota Manipulation Approaches for Colon Cancer Prevention in Rodent Models.	Tosti E, Srivastava N, Edelmann W.	Cancer Prev Res (Phila)	10.1158/1940-6207.capr-23-0015	2023
	The gut microbiota-brain connection: insights into major depressive disorder and bipolar disorder.	Zhao J, Liu J, Feng J, Liu X, Hu Q.	Front Psychiatry	10.3389/fpsyt.2024.1421490	2024
	Supplementation with Astragalus Root Powder Promotes Rumen Microbiota Density and Metabolome Interactions in Lambs.	Shao P, Sha Y, Liu X, He Y, Wang F, Hu J, Wang J, Li S, Chen X, Yang W, Chen Q, Gao M.	Animals (Basel)	10.3390/ani14050788	2024
	Gut microbiota shapes cancer immunotherapy responses.	Lei W, Zhou K, Lei Y, Li Q, Zhu H.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00786-8	2025
	Comparative Metabolomics of Clostridium acetobutylicum ATCC824 and its Engineered Strain, C. acetobutylicum DG1.	Chung JH, Lee J, Kim S, Kim KH.	J Microbiol Biotechnol	10.4014/jmb.2407.07028	2025
	Functional Comparison of Clostridium butyricum and Sodium Butyrate Supplementation on Growth, Intestinal Health, and the Anti-inflammatory Response of Broilers.	Liu L, Ling H, Zhang W, Zhou Y, Li Y, Peng N, Zhao S.	Front Microbiol	10.3389/fmicb.2022.914212	2022
	Botox: Current and Emerging Trends for Dental Practitioners in Esthetic Dentistry.	Rambole O, Reche A, Paul P.	Cureus	10.7759/cureus.64052	2024
	Effects of Fermented Liquid Feed on Growth Performance, Meat Quality, and Intestinal Microbiota of Yuedong Black Pigs.	Han G, Liu S, Zhao C, Lei L, Yi R, Ma Z, Liu J, Zhu C, Wang S, Wang L, Shu G, Jiang Q, Wu R.	Animals (Basel)	10.3390/ani15182657	2025
	Rapidly Fatal Postlaparoscopic Liver Infection from the Rarely Isolated Species Clostridium butyricum.	Muldrew KL.	Case Rep Infect Dis	10.1155/2020/1839456	2020
	Effects of Dietary Metabolizable Energy and Crude Protein Levels on the Nutrient Metabolism, Gut Development and Microbiota Composition in Jingyuan Chicken	Guo X, Liu J, Yang J, Gao Q, Zhang J, Yang W, Xin G.	Animals (Basel)		2025
Metabolism	Positive effects of a Clostridium butyricum-based compound probiotic on growth performance, immune responses, intestinal morphology, hypothalamic neurotransmitters, and colonic microbiota in weaned piglets.	Cao G, Tao F, Hu Y, Li Z, Zhang Y, Deng B, Zhan X.	Food Funct	10.1039/c8fo02370k	2019
	Clostridium butyricum and Chitooligosaccharides in Synbiotic Combination Ameliorate Symptoms in a DSS-Induced Ulcerative Colitis Mouse Model by Modulating Gut Microbiota and Enhancing Intestinal Barrier Function.	Huang X, Hu J, Zhang H, Li J, Zhu X, Liu Y, Liang Y, Mei Y.	Microbiol Spectr	10.1128/spectrum.04370-22	2023
	Strategies for Safe Transurethral Injections of Botulinum Toxin into the Bladder Wall.	Oelke M.	Toxins (Basel)	10.3390/toxins16070299	2024
	Probiotic-related bacteremia after major hepatectomy for biliary cancer: a report of two cases.	Shimura M, Mizuma M, Nakagawa K, Aoki S, Miura T, Takadate T, Ariake K, Maeda S, Kawaguchi K, Masuda K, Ishida M, Ohtsuka H, Morikawa T, Kamei T, Unno M.	Surg Case Rep	10.1186/s40792-021-01216-5	2021
	Supplemental Clostridium butyricum MIYAIRI 588 Affects Intestinal Bacterial Composition of Finishing Pigs.	Hirata M, Matsuoka M, Hashimoto T, Oura T, Ohnuki Y, Yoshida C, Minemura A, Miura D, Oka K, Takahashi M, Morimatsu F.	Microbes Environ	10.1264/jsme2.me22011	2022
	Influence of host-specific and locally isolated multi-strain probiotics on piglet performance, mortality, inflammatory response, and gut microbiome.	Sahatsanon K, Sivapirunthep P, Sringarm K, Arjin C, Hnokaew P, Chaweewan K, Chaosap C.	Anim Biosci	10.5713/ab.24.0556	2025
	Improving the non-sterile food waste bioconversion to hydrogen by microwave pretreatment and bioaugmentation with Clostridium butyricum.	Ortigueira J, Martins L, Pacheco M, Silva C, Moura P.	Waste Manag	10.1016/j.wasman.2019.03.021	2019
	Complete Genome Sequence of Clostridium butyricum Strain DKU_butyricum 4-1, Isolated from Infant Feces.	Bang MS, Jeong HW, Lee YJ, Lee SC, Lee GS, Kim S, Lee HH, Shin JI, Oh CH.	Microbiol Resour Announc	10.1128/mra.01341-19	2020
	Nasal instillation of probiotic extracts inhibits experimental allergic rhinitis.	Zeng XH, Zeng XH, Yang G, Liu JQ, Geng XR, Cheng BH, Liu ZQ, Yang PC.	Immunotherapy	10.2217/imt-2019-0119	2019
	Fermentable sugar recovery from durian peel by using ultrasound-assisted chemical pretreatment.	Yan Sim X, He N, Mohamed Abdul P, Keong Yeap S, Woh Hui Y, Foong Tiang M, Amru Indera Luthfi A, Fairuz Abdul Manaf S, Adela Bukhari N, Silvamany H, Ping Tan J.	Ultrason Sonochem	10.1016/j.ultsonch.2024.106811	2024
	Stability of probiotics with antibiotics via gastric tube by simple suspension method: An in vitro study.	Mitsuboshi S, Muto K, Okubo K, Fukuhara M.	J Infect Chemother	10.1016/j.jiac.2019.04.018	2019
Genetics	Metagenomics reveals unique gut mycobiome biomarkers in psoriasis.	Wang X, Sun J, Zhang X, Chen W, Cao J, Hu H.	Skin Res Technol	10.1111/srt.13822	2024
	Zinc Acetate Dihydrate Tablet-Associated Gastritis Occurring in a Post-Hematopoietic Stem Cell Transplant Recipient.	Iwamuro M, Tanaka T, Matsumura A, Kawano S, Kawahara Y, Okada H.	Case Rep Gastrointest Med	10.1155/2022/4637707	2022
	Gut microbiota and immunotherapy of renal cell carcinoma.	Bibbo S, Porcari S, Del Vecchio LE, Severino A, Mullish BH, Ianiro G, Gasbarrini A, Cammarota G.	Hum Vaccin Immunother	10.1080/21645515.2023.2268982	2023
	Assessment of polycyclic aromatic hydrocarbon contamination in the Sundarbans, the world's largest tidal mangrove forest and indigenous microbial mixed biofilm-based removal of the contaminants.	Balu S, Bhunia S, Gachhui R, Mukherjee J.	Environ Pollut	10.1016/j.envpol.2020.115270	2020
	Combined Treatment of Sodium Butyrate and Bromelain Enhanced Anticancer Effects in Colorectal Cancer Cell Lines: A Promising Therapeutic Approach.	Olivera-Salazar R, Villarejo Campos P, Barrueco Gutierrez R, Vega-Clemente L, Serrano LJ, Garcia Gomez-Heras S, Garcia-Olmo D, Garcia-Arranz M.	Int J Mol Sci	10.3390/ijms26199803	2025
	Clostridium butyricum alleviates LPS-induced acute immune stress in goats by regulating bacterial communities and blood metabolites.	Zhang C, Hou T, Wang J, Yu Q, Zhang Y, Sun Y.	Front Immunol	10.3389/fimmu.2023.1099186	2023
	Effects of dietary supplementation with Clostridium butyricum on laying performance, egg quality, serum parameters, and cecal microflora of laying hens in the late phase of production.	Zhan HQ, Dong XY, Li LL, Zheng YX, Gong YJ, Zou XT.	Poult Sci	10.3382/ps/pey436	2019
	Effects of Clostridium butyricum as an Antibiotic Alternative on Growth Performance, Intestinal Morphology, Serum Biochemical Response, and Immunity of Broilers.	Yang T, Du M, Zhang J, Ahmad B, Cheng Q, Wang X, Abbas Z, Tong Y, Li J, Zhou Y, Zhang R, Si D.	Antibiotics (Basel)	10.3390/antibiotics12030433	2023
	Effects of Clostridium butyricum, Sodium Butyrate, and Butyric Acid Glycerides on the Reproductive Performance, Egg Quality, Intestinal Health, and Offspring Performance of Yellow-Feathered Breeder Hens.	Wang Y, Wang Y, Lin X, Gou Z, Fan Q, Jiang S.	Front Microbiol	10.3389/fmicb.2021.657542	2021
Pathogenicity	Clostridium butyricum Strains Suppress Experimental Acute Pancreatitis by Maintaining Intestinal Homeostasis.	Pan LL, Niu W, Fang X, Liang W, Li H, Chen W, Zhang H, Bhatia M, Sun J.	Mol Nutr Food Res	10.1002/mnfr.201801419	2019
	Exploring the causal relationship between gut microbiota and atopic dermatitis: A Mendelian randomization study.	Li W, Li A.	Medicine (Baltimore)	10.1097/md.0000000000040193	2024
	Folate Production by Streptococcus thermophilus IDCC 2201 and Its Impact on Human Gut Microbiota.	Nam EH, Lee M, Kim D, Jung YH, Yang J, Shin M.	J Microbiol Biotechnol	10.4014/jmb.2502.02045	2025
Enzymology	Melatonin Promotes Muscle Growth and Redirects Fat Deposition in Cashmere Goats via Gut Microbiota Modulation and Enhanced Antioxidant Capacity.	Han D, Zheng Z, Su Z, Wang X, Ding S, Wang C, He L, Zhang W.	Antioxidants (Basel)	10.3390/antiox14060645	2025
	Efficacy of sodium butyrate in improving nonalcoholic fatty liver disease: A meta-analysis of preclinical studies.	Xu H, Wang X, Song S, Zhang L.	Medicine (Baltimore)	10.1097/md.0000000000042101	2025
	Extensive identification of serum metabolites related to microbes in different gut locations and evaluating their associations with porcine fatness.	Liu Q, He M, Zeng Z, Huang X, Fang S, Zhao Y, Ke S, Wu J, Zhou Y, Xiong X, Li Z, Fu H, Huang L, Chen C.	Microb Biotechnol	10.1111/1751-7915.14245	2023
	Phages Enter the Fight against Colorectal Cancer.	Kannen V, Parry L, Martin FL.	Trends Cancer	10.1016/j.trecan.2019.08.002	2019
	Integrated multi-omics reveals potential regulatory mechanisms of meat quality.	Wang J, Liao J, Zhao K, Shen N, Xu Y, Wang J, Jia X, Sun W, Lai S.	Food Chem (Oxf)	10.1016/j.fochms.2025.100293	2025
	The therapeutic promise of probiotic Bacteroides fragilis (BF839) in cancer immunotherapy.	Peng K, Li Y, Yang Q, Yu P, Zeng T, Lin C, Deng Y, Chen J.	Front Microbiol	10.3389/fmicb.2025.1523754	2025
	Evaluating the Impact of the PoultryStar^®Bro Probiotic on the Incidence of Bacterial Chondronecrosis with Osteomyelitis Using the Aerosol Transmission Challenge Model.	Perera R, Alharbi K, Hasan A, Asnayanti A, Do A, Shwani A, Murugesan R, Ramirez S, Kidd M, Alrubaye AAK.	Microorganisms	10.3390/microorganisms12081630	2024
	beta-glucan protects against necrotizing enterocolitis in mice by inhibiting intestinal inflammation, improving the gut barrier, and modulating gut microbiota.	Zhang X, Zhang Y, He Y, Zhu X, Ai Q, Shi Y.	J Transl Med	10.1186/s12967-022-03866-x	2023
	Comprehensive Evaluation of Probiotic Effects on Laying Hen Physiology: From Performance to Bone and Gut Morphology	Onbasilar E, Yalcin S, Bakici C, Batur B, Kartal Y, Ahlat O, Kilicli I, Yalcin S.	Animals (Basel)		2025
	Recent advances in understanding the role of extracellular vesicles from probiotics in intestinal immunity signaling.	Kurata A, Uegaki K.	Biochem Soc Trans	10.1042/bst20240150	2025
	Dietary fermented mixed ingredient product enhances growth performance and intestinal stem cell-mediated epithelial regeneration through Wnt/beta-catenin pathway in layer chicks.	Feng Y, Zeng N, Bordbar F, Lu Z, Gao C.	Poult Sci	10.1016/j.psj.2025.104821	2025
	A Comprehensive Overview of the Past, Current, and Future Randomized Controlled Trials in Hepatic Encephalopathy.	Ilie OD, Duta R, Nita IB, Dobrin I, Gurzu IL, Girleanu I, Huiban L, Muzica C, Ciobica A, Popescu R, Cianga P, Stanciu C, Cimpoesu D, Trifan A.	Medicina (Kaunas)	10.3390/medicina59122143	2023
	A gene cluster for taurine sulfur assimilation in an anaerobic human gut bacterium.	Xing M, Wei Y, Hua G, Li M, Nanjaraj Urs AN, Wang F, Hu Y, Zhai W, Liu Y, Ang EL, Zhao H, Zhang Y.	Biochem J	10.1042/bcj20190486	2019
	Distinct Effects of Lactiplantibacillus plantarum HNU082 on Microbial Single-Nucleotide Variants in Large Intestine and Small Intestine.	Ma W, Han Z, Liu X, Cui W, Zhen D, Zhou X, Song Y, Jiang S.	Microorganisms	10.3390/microorganisms13040731	2025
	Clostridium butyricum therapy for mild-moderate Clostridioides difficile infection and the impact of diabetes mellitus.	Lee JC, Chiu CW, Tsai PJ, Lee CC, Huang IH, Ko WC, Hung YP.	Biosci Microbiota Food Health	10.12938/bmfh.2021-049	2022
	The Impact of Gastrectomy on Inflammatory Bowel Disease Risk in Gastric Cancer Patients: A Critical Analysis.	Christodoulidis G, Koumarelas KE, Tsagkidou K, Agko ES, Bartzi D, Koumarelas K, Zacharoulis D.	Curr Oncol	10.3390/curroncol31100430	2024
	Optimization of 1,3-propanediol production from fermentation of crude glycerol by immobilized Bacillus pumilus.	Pinyaphong P, La-Up A.	Heliyon	10.1016/j.heliyon.2024.e35349	2024
	Regulatory Effects of the Probiotic Clostridium butyricum on Gut Microbes, Intestinal Health, and Growth Performance of Chickens.	Liu M, Uyanga VA, Cao X, Liu X, Lin H.	J Poult Sci	10.2141/jpsa.2023011	2023
	Designing function-specific minimal microbiomes from large microbial communities.	Raghu AK, Palanikumar I, Raman K.	NPJ Syst Biol Appl	10.1038/s41540-024-00373-1	2024
Metabolism	Co-production of 1,3 propanediol and long-chain alkyl esters from crude glycerol.	Mangayil R, Efimova E, Konttinen J, Santala V.	N Biotechnol	10.1016/j.nbt.2019.07.003	2019
	Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates.	Stanikova A, Jouza M, Bohosova J, Slaby O, Jabandziev P.	BMJ Paediatr Open	10.1136/bmjpo-2023-002172	2023
	Role of bacteria in cancers and their therapeutic potential: Review of current knowledge.	Wawrety W, Kedziora A.	Iran J Basic Med Sci	10.22038/ijbms.2024.77667.16798	2025
	A Novel High-Throughput Anaerobic Culture Method to Evaluate Food Health Effects via Gut Microbiota Modulation.	Liu XY, Zhu LQ, Jin QY, Peng HZ, Zhu TJ.	Food Sci Nutr	10.1002/fsn3.70978	2025
	Influence of the microbiota on the effectiveness and toxicity of oncological therapies, with a focus on chemotherapy.	Cazzaniga M, Zonzini GB, Di Pierro F, Palazzi CM, Cardinali M, Bertuccioli A.	Pathol Oncol Res	10.3389/pore.2023.1611300	2023
	Growth inhibition of sulfate-reducing bacteria for trichloroethylene dechlorination enhancement.	Lin WH, Chen CC, Sheu YT, Tsang DCW, Lo KH, Kao CM.	Environ Res	10.1016/j.envres.2020.109629	2020
	Heyndrickxia coagulans SANK70258 supplementation improves growth performance, gut health, and liver function in growing pigs.	Aida M, Yamada R, Kawase T, Matsuo T, Tsukahara T.	Front Vet Sci	10.3389/fvets.2025.1537913	2025
	Therapeutic potential of Clostridium butyricum anticancer effects in colorectal cancer.	Xu H, Luo H, Zhang J, Li K, Lee MH.	Gut Microbes	10.1080/19490976.2023.2186114	2023
	Corticotropin-releasing factor induces inflammatory cytokines via the NLRP6-inflammatory cytokine axis in a murine model of irritable bowel syndrome.	Yu LM, Zhao KJ, Wang SS, Wang X, Lu B.	J Dig Dis	10.1111/1751-2980.12704	2019
	Armored probiotics for oral delivery.	Yang X, Wang C, Wang Q, Zhang Z, Nie W, Shang L.	Smart Med	10.1002/smmd.20230019	2023
Genetics	A causal association between esophageal cancer and the oral microbiome: a Mendelian randomization study based on an Asian population.	Hu K, Huang T, Zhang Y, Ye Z, Guo J, Zhou H.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1420625	2024
Genetics	Correlation between gut microbiota and pancreatitis: a bidirectional Mendelian randomization.	Nan B, Jin L, Wang T, Long C, Zhao H, Wang C, Zhang W.	Eur J Gastroenterol Hepatol	10.1097/meg.0000000000002861	2025
Metabolism	Clostridium butyricum Potentially Improves Immunity and Nutrition through Alteration of the Microbiota and Metabolism of Elderly People with Malnutrition in Long-Term Care.	Liu L, Chen X, Liu L, Qin H.	Nutrients	10.3390/nu14173546	2022
	Gut microbiome and its metabolites in liver cirrhosis: mechanisms and clinical implications.	Chang L, Liu Y, Li H, Yan J, Wu W, Chen N, Ma C, Zhao X, Chen J, Zhang J.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1717696	2025
	Bifid triple viable preparation combined with enteral nutrition as a supportive treatment for acute ischemic stroke: a systematic review and meta-analysis.	Kong Y, Yu Y, Deng J, Yu R, Liu X.	Front Microbiol	10.3389/fmicb.2024.1408960	2024
	Gut microbiota and intestinal immunity interaction in ulcerative colitis and its application in treatment.	Bu F, Chen K, Chen S, Jiang Y.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1565082	2025
	Towards Microbiota-Targeted Interventions in Acute Pancreatitis: Evidence From Meta-Analysis and Mendelian Randomization.	Yi A, Zhang W, Sun Y, Wei A, Xie G.	FASEB J	10.1096/fj.202501787r	2025
	Evaluation of Immunoprotective Activities of White Button Mushroom (Agaricus bisporus) Water Extract Against Major Pathogenic Bacteria (Aeromonas hydrophila or Vibrio fluvialis) in Goldfish (Carassius auratus)	Sun S, Chen J, Cui P, Yang X, Zheng Y, Ma Z, Liu Y, Liu X.	Animals (Basel)		2025
	Alterations of the intestinal mucus layer correlate with dysbiosis and immune dysregulation in human Type 1 Diabetes.	Lo Conte M, Cosorich I, Ferrarese R, Antonini Cencicchio M, Nobili A, Palmieri V, Massimino L, Lamparelli LA, Liang W, Riba M, Devecchi E, Bolla AM, Pedone E, Scavini M, Bosi E, Fasano A, Ungaro F, Diana J, Mancini N, Falcone M.	EBioMedicine	10.1016/j.ebiom.2023.104567	2023
	Effect of Feed Supplementation with Clostridium butyricum, Alone or in Combination with Carob Meal or Citrus Pulp, on Digestive and Metabolic Status of Piglets.	Lopez M, Madrid J, Hernandez F, Ros MA, Segura JC, Lopez MJ, Pallares FJ, Sanchez CJ, Martinez-Miro S.	Animals (Basel)	10.3390/ani11102924	2021
	Gram-scale chemical synthesis of galactosyllactoses and their impact on infant gut microbiota in vitro.	Meeusen E, Cao L, Delsing DJ, Groeneveld A, Heerikhuisen M, Schuren F, Boltje TJ.	Org Biomol Chem	10.1039/d3ob02069j	2024
	The interaction network between intestinal flora and cell death in microecosystem of pan-cancers.	Zhang Y, Wang C, Ruan T, Liang S, Jiang H, Wu X, Hou R, Fan H, Wang H, Ding J, Xu J.	Int J Med Sci	10.7150/ijms.111723	2025
Phylogeny	Microbial community profiling for forensic drowning diagnosis across locations and submersion times.	Su Q, Zhang X, Chen X, Yu Z, Wu W, Xiang Q, Yang C, Zhao J, Chen L, Xu Q, Liu C.	BMC Microbiol	10.1186/s12866-025-03902-y	2025
	Exploring the interaction between the gut microbiota and cyclic adenosine monophosphate-protein kinase A signaling pathway: a potential therapeutic approach for neurodegenerative diseases.	Deng F, Yang D, Qing L, Chen Y, Zou J, Jia M, Wang Q, Jiang R, Huang L.	Neural Regen Res	10.4103/nrr.nrr-d-24-00607	2025
	Case report: Recombinant human type II tumour necrosis factor receptor-antibody fusion protein induced occult hepatitis B virus reactivation leading to liver failure.	Qin Y, Zhou W, Zhou X, Li H.	J Int Med Res	10.1177/03000605241252580	2024
	Anticancer Effects of Weizmannia coagulans MZY531 Postbiotics in CT26 Colorectal Tumor-Bearing Mice by Regulating Apoptosis and Autophagy.	Zhong B, Zhao Y, Gao L, Yang G, Gao Y, Li F, Li S.	Life (Basel)	10.3390/life14101334	2024
	Probiotics-induced Changes in Intestinal Structure and Gut Microbiota Are Associated with Reduced Rate of Pimpled Eggs in the Late Laying Period of Hens.	Khogali MK, Wen K, Jauregui D, Malik HEE, Liu L, Zhao M, Gong D, Geng T.	J Poult Sci	10.2141/jpsa.0210061	2022
Pathogenicity	Dietary supplementation with Clostridium butyricum helps to improve the intestinal barrier function of weaned piglets challenged with enterotoxigenic Escherichia coli K88.	Li HH, Li YP, Zhu Q, Qiao JY, Wang WJ.	J Appl Microbiol	10.1111/jam.13936	2018
	Novel therapeutic strategies and recent advances in gut microbiota synergy with nanotechnology for colorectal cancer treatment.	Han Q, Li J, Li Z, Aishajiang R, Yu D.	Mater Today Bio	10.1016/j.mtbio.2025.101601	2025
Pathogenicity	The gut microbiome diversity of Clostridioides difficile-inoculated mice treated with vancomycin and fidaxomicin.	Yamaguchi T, Konishi H, Aoki K, Ishii Y, Chono K, Tateda K.	J Infect Chemother	10.1016/j.jiac.2019.12.020	2020
Metabolism	Dietary supplementation with Clostridium butyricum modulates serum lipid metabolism, meat quality, and the amino acid and fatty acid composition of Peking ducks.	Liu Y, Li Y, Feng X, Wang Z, Xia Z.	Poult Sci	10.3382/ps/pey162	2018
Metabolism	Effect of Clostridium butyricum in different forms on growth performance, disease resistance, expression of genes involved in immune responses and mTOR signaling pathway of Litopenaeus vannamai.	Li H, Tian X, Zhao K, Jiang W, Dong S.	Fish Shellfish Immunol	10.1016/j.fsi.2018.12.069	2019
	Clostridium paraputrificum in a Middle-Aged Male With Liver Disease.	Dao KT, D'Assumpcao C, Sharma R, Heidari A.	J Investig Med High Impact Case Rep	10.1177/23247096241292213	2024
	Fecal Microbiota, Forage Nutrients, and Metabolic Responses of Horses Grazing Warm- and Cool-Season Grass Pastures.	Weinert-Nelson JR, Biddle AS, Sampath H, Williams CA.	Animals (Basel)	10.3390/ani13050790	2023
	Two-Stage Bio-Hydrogen and Polyhydroxyalkanoate Production: Upcycling of Spent Coffee Grounds.	Kang BJ, Jeon JM, Bhatia SK, Kim DH, Yang YH, Jung S, Yoon JJ.	Polymers (Basel)	10.3390/polym15030681	2023
	Evaluating the relationship between dietary flavonoids intake and constipation incidence in the general US population.	Jiang C, Luo J, Shao Y.	BMC Gastroenterol	10.1186/s12876-024-03551-x	2024
	Interactions between gut microbiota and cardiovascular drugs: effects on drug therapeutic effect and side effect.	Wang T, Lan Q, Deng H, Han W, Zhang R, Zhong J.	Front Cardiovasc Med	10.3389/fcvm.2025.1570008	2025
	Effects of dietary supplementation probiotic complex on growth performance, blood parameters, fecal harmful gas, and fecal microbiota in AA+ male broilers.	Zou Q, Fan X, Xu Y, Wang T, Li D.	Front Microbiol	10.3389/fmicb.2022.1088179	2022
	Impact of probiotics on sleep quality and mood states in patients with insomnia: a systematic review and meta-analysis.	Liu Y, Yu Y, Lu S, Tan K, Jiang P, Liu P, Peng Q.	Front Microbiol	10.3389/fmicb.2025.1596990	2025
	Long-term performance and acute toxicity assessment of scaled-up air-cathode microbial fuel cell fed by dairy wastewater.	Marassi RJ, Queiroz LG, Silva DCVR, Dos Santos FS, Silva GC, de Paiva TCB.	Bioprocess Biosyst Eng	10.1007/s00449-020-02348-y	2020
	Treatment of Acute Ulcerative Colitis with Zinc Hyaluronate in Mice.	Zhang L, Fu X, Li J, Xiao W, Xiong X, Lv H, Zhang Z, Ju J.	J Microbiol Biotechnol	10.4014/jmb.2408.08050	2025
	Probiotic Potential of Clostridium spp.-Advantages and Doubts.	Grenda T, Grenda A, Domaradzki P, Krawczyk P, Kwiatek K.	Curr Issues Mol Biol	10.3390/cimb44070215	2022
	Colorectal cancer and microbiota: systematic review.	Imanbayev N, Iztleuov Y, Bekmukhambetov Y, Abdelazim IA, Donayeva A, Amanzholkyzy A, Aigul Z, Aigerim I, Aslan Y.	Prz Gastroenterol	10.5114/pg.2024.136228	2024
	Probiotic Influences on Motor Skills: A Review.	Lalonde R, Strazielle C.	Curr Neuropharmacol	10.2174/1570159x21666230807150523	2023
	Significantly Delayed Development of Polyarthritis with Active Tenosynovitis after Possible Temporary Neutropenic Immune-Related Adverse Events Caused by Atezolizumab Treatment: A Novel Case Report.	Saito Y, Takekuma Y, Asahina H, Hisada R, Sugawara M.	Case Rep Oncol Med	10.1155/2024/1566299	2024
	Effects of Clostridium butyricum and a Bacteriophage Cocktail on Growth Performance, Serum Biochemistry, Digestive Enzyme Activities, Intestinal Morphology, Immune Responses, and the Intestinal Microbiota in Rabbits.	Huang P, Cui X, Wang Z, Xiao C, Ji Q, Wei Q, Huang Y, Bao G, Liu Y.	Antibiotics (Basel)	10.3390/antibiotics10111347	2021
Transcriptome	Research Note: Transcriptome analysis reveals differentially expressed genes regulated muscle development in Pekin ducks during dietary threonine deficiency.	Jia W, Wu L, Zhuang Z, Xu M, Lu Y, Wang Z, Bai H, Chen G, Chang G, Jiang Y.	Poult Sci	10.1016/j.psj.2023.103168	2023
	Early life gut microbiota sustains liver-resident natural killer cells maturation via the butyrate-IL-18 axis.	Tian P, Yang W, Guo X, Wang T, Tan S, Sun R, Xiao R, Wang Y, Jiao D, Xu Y, Wei Y, Wu Z, Li C, Gao L, Ma C, Liang X.	Nat Commun	10.1038/s41467-023-37419-7	2023
	Phase 1/2, open-label study of oral bacterial supplementation (EDP1503) plus pembrolizumab in participants with advanced or metastatic microsatellite-stable colorectal cancer, triple-negative breast cancer, and checkpoint inhibitor-relapsed tumors.	Wang JS, Arrowsmith ER, Beck JT, Friedmann J, Jamal R, McHale D, Gardner H, Chisamore MJ, Ulahannan SV.	Invest New Drugs	10.1007/s10637-025-01573-0	2025
	Molecular characterization, developmental expression, and modulation of occludin by early intervention with Clostridium butyricum in Muscovy ducks.	Lyu W, Yang H, Li N, Lu L, Yang C, Jin P, Xiao Y.	Poult Sci	10.1016/j.psj.2021.101271	2021
	Alterations in Ileal Microbiota and Fecal Metabolite Profiles of Chickens with Immunity to Eimeria mitis.	Wang Z, Shang P, Song X, Wu M, Zhang T, Zhao Q, Zhu S, Qiao Y, Zhao F, Zhang R, Wang J, Yu Y, Han H, Dong H.	Animals (Basel)	10.3390/ani14233515	2024
	COVID-19 face masks attracted Cellulomonas and Acinetobacter bacteria and provided breeding haven for red cotton bug (Dysdercus suturellus) and house cricket (Acheta domesticus).	Idowu GA, Olalemi AO, Ileke KD.	Environ Sci Pollut Res Int	10.1007/s11356-022-23865-1	2023
	Kaempferol Alleviates Carbon Tetrachloride-Induced Liver Fibrosis in Mice by Regulating Intestinal Short-Chain Fatty Acids.	Zhang S, Tang F, Zhou Z, Li L, Tang Y, Fu K, Tan Y, Li L.	Int J Mol Sci	10.3390/ijms26146666	2025
Genetics	A dual-scale fused hypergraph convolution-based hyperedge prediction model for predicting missing reactions in genome-scale metabolic networks.	Huang W, Yang F, Zhang Q, Liu J.	Brief Bioinform	10.1093/bib/bbae383	2024
	Growth performance, non-specific immunity, intestinal histology and disease resistance of Litopenaeus vannamei fed on a diet supplemented with live cells of Clostridium butyricum	Li Hd, Tian Xl, Dong Sl.	Aquaculture	10.1016/j.aquaculture.2018.09.003	2019
	Optimizing sustainable control of Meloidogyne javanica in tomato plants through gamma radiation-induced mutants of Trichoderma harzianum and Bacillus velezensis.	Rostami M, Shahbazi S, Soleimani R, Ghorbani A.	Sci Rep	10.1038/s41598-024-68365-z	2024
Pathogenicity	Lactobacillus acidophilus and Clostridium butyricum ameliorate colitis in murine by strengthening the gut barrier function and decreasing inflammatory factors.	Wang Y, Gu Y, Fang K, Mao K, Dou J, Fan H, Zhou C, Wang H.	Benef Microbes	10.3920/bm2017.0035	2018
	New probiotics (Lactobacillus plantarum and Saccharomyces cerevisiae) supplemented to fermented rice straw-based rations on digestibility and rumen characteristics in vitro.	Marlida Y, Harnentis H, Nur YS, Ardani LR.	J Adv Vet Anim Res	10.5455/javar.2023.j657	2023
Pathogenicity	The Anti-Inflammatory Activities of Fermented Curcuma That Contains Butyrate Mitigate DSS-Induced Colitis in Mice.	Bayazid AB, Jeong SA, Park CW, Kim DH, Lim BO.	Molecules	10.3390/molecules27154745	2022
	Clostridium butyricum Attenuates Chronic Unpredictable Mild Stress-Induced Depressive-Like Behavior in Mice via the Gut-Brain Axis.	Sun J, Wang F, Hu X, Yang C, Xu H, Yao Y, Liu J.	J Agric Food Chem	10.1021/acs.jafc.8b02462	2018
Metabolism	Clostridium butyricum protects the epithelial barrier by maintaining tight junction protein expression and regulating microflora in a murine model of dextran sodium sulfate-induced colitis.	Li H, Gong Y, Xie Y, Sun Q, Li Y.	Scand J Gastroenterol	10.1080/00365521.2016.1192678	2018
Enzymology	The impact of Clostridium butyricum MIYAIRI 588 on the murine gut microbiome and colonic tissue.	Hagihara M, Yamashita R, Matsumoto A, Mori T, Kuroki Y, Kudo H, Oka K, Takahashi M, Nonogaki T, Yamagishi Y, Mikamo H.	Anaerobe	10.1016/j.anaerobe.2018.07.012	2018
	Clostridium butyricum potentially improves inflammation and immunity through alteration of the microbiota and metabolism of gastric cancer patients after gastrectomy.	Cao W, Zheng C, Xu X, Jin R, Huang F, Shi M, He Z, Luo Y, Liu L, Liu Z, Wei J, Deng X, Chen T.	Front Immunol	10.3389/fimmu.2022.1076245	2022
	Multiple perinatal characteristics affect the association between maternal diabetes status and early neonatal gut microbiota.	Liu C, Zheng W, Wang J, Yuan X, Zhang Y, Wang Y, Ma X, Li G.	mSphere	10.1128/msphere.00914-24	2025
	Gut microbiota and metabolite features in NSCLC nude mouse models of subcutaneous tumor and leptomeningeal metastasis: a microbiome-metabolome combined analysis.	Du Y, Fan C, Song X, Teng C, Zhang Z, Zhang J, Zhao T, Xin T.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1616695	2025
Pathogenicity	Clostridium butyricum promotes intestinal motility by regulation of TLR2 in interstitial cells of Cajal.	Sui SJ, Tian ZB, Wang QC, Chen R, Nie J, Li JS, Wei LZ.	Eur Rev Med Pharmacol Sci	10.26355/eurrev_201807_15533	2018
	Multiple ulcers and perforation of small intestine with everolimus use in a patient with rectal neuroendocrine tumor: A case report.	Abe K, Emoto S, Sasaki K, Nozawa H, Yasunaga Y, Ishihara S.	Int J Surg Case Rep	10.1016/j.ijscr.2023.108094	2023
	Improvement of 1,3-propanediol production from crude glycerol by co-cultivation of anaerobic and facultative microbes under non-strictly anaerobic conditions.	Sun Y, Liang L, Zheng Y, Han J, Xiu Z.	Biotechnol Biofuels Bioprod	10.1186/s13068-022-02143-9	2022
	Gut microbial metabolite butyrate suppresses hepatocellular carcinoma growth via CXCL11-dependent enhancement of natural killer cell infiltration.	Zhang M, Huang X, Zhang Y, Yu M, Yuan X, Xu Y, Ma L, Wang X, Xing H.	Gut Microbes	10.1080/19490976.2025.2519706	2025
	Clostridium butyricum MIYAIRI 588 as Adjunctive Therapy for Treatment-Resistant Major Depressive Disorder: A Prospective Open-Label Trial.	Miyaoka T, Kanayama M, Wake R, Hashioka S, Hayashida M, Nagahama M, Okazaki S, Yamashita S, Miura S, Miki H, Matsuda H, Koike M, Izuhara M, Araki T, Tsuchie K, Azis IA, Arauchi R, Abdullah RA, Oh-Nishi A, Horiguchi J.	Clin Neuropharmacol	10.1097/wnf.0000000000000299	2018
	Pathways for accelerated bacterial spore killing with ohmic heating.	Singh SK, Samaranayake CP, Korza G, Ali MM, Setlow P, Sastry S.	NPJ Sci Food	10.1038/s41538-025-00537-1	2025
	Maternal intestinal L. vaginalis facilitates embryo implantation and survival through enhancing uterine receptivity in sows.	Ye Q, Hu Y, Jiang H, Luo T, Han L, Chen Y, Chen J, Ma L, He Z, Yan X.	Microbiome	10.1186/s40168-025-02141-7	2025
Pathogenicity	Protective effects of a mixture of multi-strain native Iranian probiotics on lead acetate-induced toxicity in the kidney of male rats: An integrated biochemical, molecular and histopathological study.	Akbaribazm M, Abdol Al Amir Mohammad Javad Z, Alavi SN, Keshtmand Z.	Avicenna J Phytomed	10.22038/ajp.2024.24261	2024
	A novel isolate of Clostridium butyricum for efficient butyric acid production by xylose fermentation	Wang X, Li J, Chi X, Zhang Y, Yan H, Jin Y, Qu J.	Ann Microbiol	10.1007/s13213-018-1340-4	2018
Metabolism	Stability and oscillatory behavior of microbial consortium in continuous conversion of crude glycerol to 1,3-propanediol.	Zhou JJ, Shen JT, Wang XL, Sun YQ, Xiu ZL.	Appl Microbiol Biotechnol	10.1007/s00253-018-9244-6	2018
	Targeted ileal microbiome modulation by in ovo seaweed polyphenols (Fucus spiralis) as an alternative to in-feed antibiotics in broiler chickens.	Lu J, Petri RM, Foster J, Collins SA.	Poult Sci	10.1016/j.psj.2025.105976	2025
	Whole-Genome Shotgun Sequencing and Characterization of Probiotic Strain Clostridium butyricum UBCB 70 To Assess Its Safety.	Sulthana A, Thorramamidi A, Lakshmi SG, Madempudi RS.	Microbiol Resour Announc	10.1128/mra.01732-18	2019
	Spore-Forming Clostridia in Raw Cow Milk from Northern Italy: A Trend Analysis over the Past 20 Years.	Guaita A, Gambi L, Baresi P, Paterlini F, Bolzoni G, Zanardi G, Daminelli P.	Foods	10.3390/foods13223638	2024
	Tolerability of nintedanib-related diarrhea in patients with idiopathic pulmonary fibrosis.	Hirasawa Y, Abe M, Terada J, Sakayori M, Suzuki K, Yoshioka K, Kawasaki T, Tsushima K, Tatsumi K.	Pulm Pharmacol Ther	10.1016/j.pupt.2020.101917	2020
	The Potential Role of Probiotics in the Management of Osteoarthritis Pain: Current Status and Future Prospects.	Rahman SO, Bariguian F, Mobasheri A.	Curr Rheumatol Rep	10.1007/s11926-023-01108-7	2023
	The First Reported Foodborne Botulism Outbreak in Riyadh, Saudi Arabia: Lessons Learned.	Gul Dar N, Alfaraj SH, Alboqmy KN, Khanum N, Alshakrah F, Abdallah H, Badawi MH, Alharbi OM, Alshiekh KA, Alsallum AM, Shrahili AH, Zeidan ZA, Abdallah Z, Majrashi AA, Memish ZA.	J Epidemiol Glob Health	10.1007/s44197-024-00255-z	2024
	Probiotic as a Potential Gut Microbiome Modifier for Stroke Treatment: A Systematic Scoping Review of In Vitro and In Vivo Studies.	Savigamin C, Samuthpongtorn C, Mahakit N, Nopsopon T, Heath J, Pongpirul K.	Nutrients	10.3390/nu14173661	2022
	The Application of Traditional Chinese Medicine-Derived Formulations in Cancer Immunotherapy: A Review.	Li Y, Li C, Fan J, Liu Y, Xu Y, Pang G.	Cancer Manag Res	10.2147/cmar.s503071	2025
Genetics	Characterization and Preliminary Application of a Novel Lytic Vibrio parahaemolyticus Bacteriophage vB_VpaP_SJSY21.	Xu Y, Sun J, Hu J, Bao Z, Wang M.	Int J Mol Sci	10.3390/ijms242417529	2023
Metabolism	Clostridium butyricum regulates visceral hypersensitivity of irritable bowel syndrome by inhibiting colonic mucous low grade inflammation through its action on NLRP6.	Zhao K, Yu L, Wang X, He Y, Lu B.	Acta Biochim Biophys Sin (Shanghai)	10.1093/abbs/gmx138	2018
	Bifidobacterium compound preparations as a supplementary treatment for severe ischemic stroke: a systematic review and meta-analysis.	Lu S, Yu Y, Liu Y, Zhang H, Liu R, Liu J.	Front Microbiol	10.3389/fmicb.2025.1577898	2025
	Worldwide Research Trends on Lung Cancer and Microbiota: A Bibliometric and Visualized Analysis.	Ren YF, Tan SY, Wang Q, He JW, You FM, Ma Q, You LT.	J Multidiscip Healthc	10.2147/jmdh.s516036	2025
Enzymology	Construction of a Model Culture System of Human Colonic Microbiota to Detect Decreased Lachnospiraceae Abundance and Butyrogenesis in the Feces of Ulcerative Colitis Patients.	Sasaki K, Inoue J, Sasaki D, Hoshi N, Shirai T, Fukuda I, Azuma T, Kondo A, Osawa R.	Biotechnol J	10.1002/biot.201800555	2019
	Gut Microbiota Modification via Glucagon-like Peptide-1 with Beneficial Neuroprotective Effects.	Sayehmiri F, Samadian M, Mohamadkhani A, Tafakhori A, Haghighat S, Rahmatian A, Mohammadkhani MA, Fazli HR, Rezaei Tavirani M.	Middle East J Dig Dis	10.34172/mejdd.2022.278	2022
Pathogenicity	Early Life Intervention Using Probiotic Clostridium butyricum Improves Intestinal Development, Immune Response, and Gut Microbiota in Large Yellow Croaker (Larimichthys crocea) Larvae.	Yin Z, Liu Q, Liu Y, Gao S, He Y, Yao C, Huang W, Gong Y, Mai K, Ai Q.	Front Immunol	10.3389/fimmu.2021.640767	2021
	Genome manipulation by guide-directed Argonaute cleavage.	Huang S, Wang K, Mayo SL.	Nucleic Acids Res	10.1093/nar/gkad188	2023
	Effects of Different Hemicellulose Components on Fermentation Kinetics and Microbial Composition in Fecal Inoculum from Suckling Piglets In Vit ro.	Gao G, Cai L, Fan Y, Aroche Ginarte R, Li Y, Sun W, Jiang X, Li X, Pi Y.	ACS Omega	10.1021/acsomega.4c08848	2025
Phylogeny	Dietary supplementation with Clostridium butyricum improves growth performance of broilers by regulating intestinal microbiota and mucosal epithelial cells.	Xu L, Sun X, Wan X, Li K, Jian F, Li W, Jiang R, Han R, Li H, Kang X, Wang Y.	Anim Nutr	10.1016/j.aninu.2021.01.009	2021
	Efficacy of Life Protection Probably from Newly Isolated Bacteria against Cisplatin-Induced Lethal Toxicity.	Ikeda Y, Suga N, Matsuda S.	Microorganisms	10.3390/microorganisms11092246	2023
Metabolism	Xylan supplement improves 1,3-propanediol fermentation by Clostridium butyricum.	Apiwatanapiwat W, Vaithanomsat P, Thanapase W, Ratanakhanokchai K, Kosugi A.	J Biosci Bioeng	10.1016/j.jbiosc.2017.12.006	2018
	Long-term H2 photoproduction from starch by co-culture of Clostridium butyricum and Rhodobacter sphaeroides in a repeated batch process	Laurinavichene T, Laurinavichius K, Shastik E, Tsygankov A.	Biotechnol Lett		2018
Metabolism	Effects of dietary Lactobacillus rhamnosus GG supplementation on the production performance, egg quality, eggshell ultrastructure, and lipid metabolism of late-phase laying hens.	Liu L, Zhang G, Qu G, Liu B, Zhang X, Li G, Jin N, Li C, Bai J, Zhao C.	BMC Vet Res	10.1186/s12917-023-03719-9	2023
	The effects of Clostridium butyricum on Ira rabbit growth performance, cecal microbiota and plasma metabolome.	Ye XX, Li KY, Li YF, Lu JN, Guo PT, Liu HY, Zhou LW, Xue SS, Huang CY, Fang SM, Gan QF.	Front Microbiol	10.3389/fmicb.2022.974337	2022
	A Critical Perspective on the Supplementation of Akkermansia muciniphila: Benefits and Harms.	Chiantera V, Lagana AS, Basciani S, Nordio M, Bizzarri M.	Life (Basel)	10.3390/life13061247	2023
	Combination of probiotics with different functions alleviate DSS-induced colitis by regulating intestinal microbiota, IL-10, and barrier function.	Wang Y, Xie Q, Zhang Y, Ma W, Ning K, Xiang JY, Cui J, Xiang H.	Appl Microbiol Biotechnol	10.1007/s00253-019-10259-6	2020
	Anesthetic Management Using Remimazolam in a Hemodialysis Patient.	Nishioka Y, Miyake S, Hamaoka M, Miyake K, Fujimoto M, Higuchi H, Miyawaki T.	Anesth Prog	10.2344/anpr-70-02-06	2023
	Shifts in the skin microbiome associated with diaper dermatitis and emollient treatment amongst infants and toddlers in China.	Zheng Y, Wang Q, Ma L, Chen Y, Gao Y, Zhang G, Cui S, Liang H, Song L, He C.	Exp Dermatol	10.1111/exd.14028	2019
Metabolism	Enhancing Light-Driven 1,3-Propanediol Production by Using Natural Compartmentalization of Differentiated Cells.	Liu H, Ni J, Xu P, Tao F.	ACS Synth Biol	10.1021/acssynbio.8b00239	2018
Pathogenicity	The development of probiotics and prebiotics therapy to ulcerative colitis: a therapy that has gained considerable momentum.	Guo J, Li L, Cai Y, Kang Y.	Cell Commun Signal	10.1186/s12964-024-01611-z	2024
	Pregnancy outcomes in pregnant women taking oral probiotic undergoing cerclage compared to placebo: two blinded randomized controlled trial.	Vanda R, Dastani T, Taghavi SA, Sadeghi H, Lambert N, Bazarganipour F.	BMC Pregnancy Childbirth	10.1186/s12884-024-06496-x	2024
	The Synergistic Role of Sargassum horneri Fucoidan and Lactobacillus plantarum: Microbiome and Gut Barrier Restoration in Zebrafish Colitis.	Liyanage NM, Nagahawatta DP, Jayawardhana HHACK, Je JG, Yiqiao L, Yang F, Kim YS, Ko KY, Jeon YJ.	Mar Drugs	10.3390/md23100372	2025
Metabolism	Metabolic profiles analysis of 1,3-propanediol production process by Clostridium butyricum through repeated batch fermentation coupled with activated carbon adsorption.	Zhang AH, Liu HL, Huang SY, Fu YS, Fang BS.	Biotechnol Bioeng	10.1002/bit.26488	2018
	Mechanisms of enhanced biohydrogen production from macroalgae by ferrous ion: Insights into correlations of microbes and metabolites.	Yin Y, Wang J.	Bioresour Technol	10.1016/j.biortech.2019.121808	2019
	Reoccurrence of takotsubo cardiomyopathy induced by osimertinib: A case report.	Fukuda Y, Kawa Y, Nonaka A, Shiotani H.	Clin Case Rep	10.1002/ccr3.6279	2022
Enzymology	Production of 1,3-propanediol using a novel 1,3-propanediol dehydrogenase from isolated Clostridium butyricum and co-biotransformation of whole cells.	Yun J, Yang M, Magocha TA, Zhang H, Xue Y, Zhang G, Qi X, Sun W.	Bioresour Technol	10.1016/j.biortech.2017.09.180	2018
	Research and application of intelligent diagnosis and treatment engineering bacteria.	Zhao N, Chen J, Shi J, Gao Y, Li L, Dong L.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1524376	2024
	Enhancing syntrophic associations among Clostridium butyricum, Syntrophomonas and two types of methanogen by zero valent iron in an anaerobic assay with a high organic loading.	Kong X, Yu S, Fang W, Liu J, Li H.	Bioresour Technol	10.1016/j.biortech.2018.02.088	2018
Enzymology	The Protective Effects of Microbe Derived Antioxidants on Digestive Tissue Morphology, Functions, and Intestinal Microbiota Diversity of Eriocheir sinensis Exposed to Glyphosate.	Song Y, Wu M, Cheng Y, Niu C, Yu X, Pang Y, Yang X.	Aquac Nutr	10.1155/anu/2620217	2024
	Herbal Combination of Angelica gigas, Zingiber officinale, and Aconitum carmichaeli Alleviates High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice Through NRF2-Mediated Regulation of Adipogenesis and Non-Shivering Thermogenesis.	Kim H, Kim HL, Boo M, Choi H, Han J, Nam S, Kang SJ, Kim JK, Han Y, Jung JH, Kim W, Kim KI, Um JY, Park J, Otterbein LE, Kim HI, Ko SG.	Food Sci Nutr	10.1002/fsn3.71199	2025
	Clostridium butyricum and Bifidobacterium pseudolongum Attenuate the Development of Cardiac Fibrosis in Mice.	Wang J, Chen J, Li L, Zhang H, Pang D, Ouyang H, Jin X, Tang X.	Microbiol Spectr	10.1128/spectrum.02524-22	2022
	Recent nutritional strategies and feed additives to stimulate proper rumen development in young goats.	Abdelsattar MM, Zhao W, Diaby M, Vargas-Bello-Perez E, Zhang N.	Transl Anim Sci	10.1093/tas/txae164	2025
	Clostridium butyricum and Its Derived Extracellular Vesicles Modulate Gut Homeostasis and Ameliorate Acute Experimental Colitis.	Ma L, Shen Q, Lyu W, Lv L, Wang W, Yu M, Yang H, Tao S, Xiao Y.	Microbiol Spectr	10.1128/spectrum.01368-22	2022
Phylogeny	Functional proteins in breast milk and their correlation with the development of the infant gut microbiota: a study of mother-infant pairs.	Xi M, Liang D, Yan Y, Duan S, Leng H, Yang H, Shi X, Na X, Yang Y, Yang C, Szeto IM, Zhao A.	Front Microbiol	10.3389/fmicb.2023.1239501	2023
	The Joint Contribution of Host Genetics and Probiotics to Pig Growth Performance.	Han J, Wang M, Zhou S, Wang Z, Duan D, Li M, Li X, Xin W, Li X.	Microorganisms	10.3390/microorganisms13020358	2025
	A multi-omics approach exploring the gut-liver axis following combined radiation exposure and burn injury in a Sinclair minipig model.	Horseman TS, Parajuli B, Murthy V, Holmes-Hampton GP, Sukumar G, Dalgard CL, Anderson JA, Burmeister DM.	Sci Rep	10.1038/s41598-025-24946-0	2025
	Oral administration of Clostridium butyricum rescues streptomycin-exacerbated respiratory syncytial virus-induced lung inflammation in mice.	Zhu W, Wang J, Zhao N, Zheng R, Wang D, Liu W, Liu B.	Virulence	10.1080/21505594.2021.1962137	2021
Phylogeny	Paraclostridium is the Main Genus of Anaerobic Bacteria Isolated from New Species of the Marine Sponge Plakina in the Brazilian Southeast Coast.	de Oliveira BFR, Cavalcanti MD, de Oliveira Nunes S, Lobo LA, Domingues RMCP, Muricy G, Laport MS.	Curr Microbiol	10.1007/s00284-019-01684-x	2019
	Difference of Microbial Community in the Stream Adjacent to the Mixed Antibiotic Effluent Source.	Kim JW, Hong YK, Kwon OK, Kim SC.	Toxics	10.3390/toxics12020135	2024
	Impact of Ivermectin on the Gut Microbial Ecosystem	Liu L, Mahalak K, Bobokalonov J, Narrowe A, Firrman J, Lemons J, Bittinger K, Hu W, Jones S, Moustafa A.	Int J Mol Sci		2023
Pathogenicity	Gut microbiota composition and dietary interventions modulate abdominal fat deposition in poultry: Mechanisms and applications.	Gibril BAA, Tu X, Chai X, Xu J.	Poult Sci	10.1016/j.psj.2025.105754	2025
	Association of probiotic use with nivolumab effectiveness against various cancers: A multicenter retrospective cohort study.	Arai J, Niikura R, Hayakawa Y, Suzuki N, Honda T, Okamura T, Hasatani K, Yoshida N, Nishida T, Sumiyoshi T, Kiyotoki S, Ikeya T, Arai M, Boku N, Fujishiro M.	Cancer Med	10.1002/cam4.6313	2023
	Gut microbiota and sepsis-associated encephalopathy: pathogenesis and precision therapies.	Wei N, Dai S, Li W, Zhou J, Chen Y.	Front Neurosci	10.3389/fnins.2025.1596467	2025
Metabolism	Long-term H₂ photoproduction from starch by co-culture of Clostridium butyricum and Rhodobacter sphaeroides in a repeated batch process.	Laurinavichene T, Laurinavichius K, Shastik E, Tsygankov A.	Biotechnol Lett	10.1007/s10529-017-2486-z	2018
	Causal association between gut microbiota and fibromyalgia: a Mendelian randomization study.	Wang Z, Jiang D, Zhang M, Teng Y, Huang Y.	Front Microbiol	10.3389/fmicb.2023.1305361	2023
	Comparative analysis of fecal microbiota between diarrhea and non-diarrhea piglets reveals biomarkers of gut microbiota associated with diarrhea.	Zhu J, Sun Y, Ma L, Chen Q, Hu C, Yang H, Hong Q, Xiao Y.	Anim Nutr	10.1016/j.aninu.2024.05.013	2024
	Repopulation of the gut microbiota after a screening colonoscopy.	Ghouri YA, Ericsson AC, Anderson JM, George JG, Parks EJ, Anguah KOB.	PLoS One	10.1371/journal.pone.0320712	2025
	Glucosylceramide Changes Bacterial Metabolism and Increases Gram-Positive Bacteria through Tolerance to Secondary Bile Acids In Vitro.	Dai H, Otsuka A, Tanabe K, Yanagita T, Nakayama J, Kitagaki H.	Int J Mol Sci	10.3390/ijms23105300	2022
	MADET: a Manually Curated Knowledge Base for Microbiomic Effects on Efficacy and Toxicity of Anticancer Treatments.	Zhang J, Chen X, Zou J, Li C, Kang W, Guo Y, Liu S, Zhao W, Mou X, Huang J, Ke J.	Microbiol Spectr	10.1128/spectrum.02116-22	2022
	Comparative phenotypic analysis of "Clostridium neonatale" and Clostridium butyricum isolates from neonates.	Schonherr-Hellec S, Klein G, Delannoy J, Ferraris L, Friedel I, Roze JC, Butel MJ, Aires J.	Anaerobe	10.1016/j.anaerobe.2017.07.002	2017
Metabolism	Effects of the butyric acid-producing strain Clostridium butyricum MIYAIRI 588 on broiler and piglet zootechnical performance and prevention of necrotic enteritis.	Takahashi M, McCartney E, Knox A, Francesch M, Oka K, Wada K, Ideno M, Uno K, Kozlowski K, Jankowski J, Gracia MI, Morales J, Kritas SK, Esteve-Garcia E, Kamiya S.	Anim Sci J	10.1111/asj.13006	2018
	Clostridium butyricum therapy restores the decreased efficacy of immune checkpoint blockade in lung cancer patients receiving proton pump inhibitors.	Tomita Y, Goto Y, Sakata S, Imamura K, Minemura A, Oka K, Hayashi A, Jodai T, Akaike K, Anai M, Hamada S, Iyama S, Saruwatari K, Saeki S, Takahashi M, Ikeda T, Sakagami T.	Oncoimmunology	10.1080/2162402x.2022.2081010	2022
	Ozone rectal insufflation inhibits the development of atherosclerosis in ApoE-/-mice, which is mediated by the regulation of gut microbiota and metabolites.	Li R, Wang Y, Ji X, Han Q, He K, Zhao H, Li H.	Front Microbiol	10.3389/fmicb.2025.1597695	2025
	Effect of Clostridium butyricum on Gastrointestinal Infections.	Ariyoshi T, Hagihara M, Takahashi M, Mikamo H.	Biomedicines	10.3390/biomedicines10020483	2022
	Oral Astragalus polysaccharide alleviates adenine-induced kidney injury by regulating gut microbiota-short-chain fatty acids-kidney G protein-coupled receptors axis.	Liu W, Zhang Y, Hu D, Huang L, Liu X, Lu Z.	Ren Fail	10.1080/0886022x.2024.2429693	2024
	Effects of Clostridium butyricum on Growth Performance, Gut Microbiota and Intestinal Barrier Function of Broilers.	Li W, Xu B, Wang L, Sun Q, Deng W, Wei F, Ma H, Fu C, Wang G, Li S.	Front Microbiol	10.3389/fmicb.2021.777456	2021
Phylogeny	Functional gene-guided enrichment plus in situ microsphere cultivation enables isolation of new crucial ureolytic bacteria from the rumen of cattle.	Liu S, Yu Z, Zhong H, Zheng N, Huws S, Wang J, Zhao S.	Microbiome	10.1186/s40168-023-01510-4	2023
Metabolism	Dietary Clostridium butyricum Induces a Phased Shift in Fecal Microbiota Structure and Increases the Acetic Acid-Producing Bacteria in a Weaned Piglet Model.	Zhang J, Chen X, Liu P, Zhao J, Sun J, Guan W, Johnston LJ, Levesque CL, Fan P, He T, Zhang G, Ma X.	J Agric Food Chem	10.1021/acs.jafc.8b01253	2018
	Effect of Growth Stage on Nutrition, Fermentation Quality, and Microbial Community of Semidry Silage from Forage Soybean.	Wang K, Sun S, Zou Y, Gao Y, Gao Z, Wang B, Hua Y, Lu Y, Hu G, Qin L.	Plants (Basel)	10.3390/plants13050739	2024
	An Update on the Pivotal Roles of Probiotics, Their Components, and Metabolites in Preventing Colon Cancer.	Deng X, Yang J, Zhang Y, Chen X, Wang C, Suo H, Song J.	Foods	10.3390/foods12193706	2023
Metabolism	Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axis.	Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J.	Neurogastroenterol Motil	10.1111/nmo.13260	2018
	Effects of dietary supplementation of Poria cocos polysaccharides on intestinal barrier, immune function, and growth of Hyla rabbits.	Wei WY, Zhou XP, Yang XL, Zong Y, Shi K, Li JM, Diao NC, Du R, Zeng FL.	Front Vet Sci	10.3389/fvets.2025.1643620	2025
	A Case of Hepatitis E Virus Infection: One of Differential Diagnosis of Liver Injury in Patients Undergoing Peritoneal Dialysis.	Yan T, Sakai Y, Terada K, Okano S, Kawasaki S, Kashiwagi T, Iwabu M.	Int Med Case Rep J	10.2147/imcrj.s385393	2022
	The efficacy and safety of Clostridium butyricum and Bacillus coagulans in Helicobacter pylori eradication treatment: An open-label, single-arm pilot study.	Zhang J, Guo J, Li D, Chen M, Liu J, Feng C, He Q, Zhao J, Zhang L, Chen J, Shi Y.	Medicine (Baltimore)	10.1097/md.0000000000022976	2020
	Presume Why Probiotics May Not Provide Protection in Inflammatory Bowel Disease through an Azoxymethane and Dextran Sodium Sulfate Murine Model.	Hu ML, Lian WS, Wang FS, Yang CH, Huang WT, Yang JW, Chen IY, Yang MY.	Int J Mol Sci	10.3390/ijms23179689	2022
	Isolation, Enrichment and Analysis of Aerobic, Anaerobic, Pathogen-Free and Non-Resistant Cellulose-Degrading Microbial Populations from Methanogenic Bioreactor.	Dimitrova L, Ilieva Y, Gouliamova D, Kussovski V, Hubenov V, Georgiev Y, Bratanova T, Kaleva M, Zaharieva MM, Najdenski H.	Genes (Basel)	10.3390/genes16050551	2025
	Optimizing the Routine Use of Clinical Guidelines by Addition of Supplements (Probiotics and/or Bismuth) to Helicobacter pylori Eradication Protocols in a Clarithromycin Resistant and Tetracycline/Bismuth Naive Area: A Real-World Data Retrospective Analysis of 402 Cases (2016-24) in a Single Gastroenterology Unit.	Gelley A, Keri N, Birinyi P, Komka K, Hardy V, Dongolo L, Szeli D, Czegle I.	Antibiotics (Basel)	10.3390/antibiotics14090870	2025
Metabolism	CBP22, a Novel Bacteriocin Isolated from Clostridium butyricum ZJU-F1, Protects against LPS-Induced Intestinal Injury through Maintaining the Tight Junction Complex.	Wang T, Fu J, Xiao X, Lu Z, Wang F, Jin M, Wang Y, Zong X.	Mediators Inflamm	10.1155/2021/8032125	2021
	Quantitative and dynamic profiling of human gut core microbiota by real-time PCR.	Yan Z, Hao T, Yan Y, Zhao Y, Wu Y, Tan Y, Bi Y, Cui Y, Yang R, Zhao Y.	Appl Microbiol Biotechnol	10.1007/s00253-024-13204-4	2024
	Live bacterial supplementation for improving treatment response in metastatic renal cell carcinoma.	Meza L, Govindarajan A, Feng M, Pal SK.	Clin Transl Med	10.1002/ctm2.948	2022
	Effect of multi-strain bifidobacteria supplementation on intestinal microbiota development in low birth weight neonates: a randomized controlled trial.	Takeshita K, Takei H, Tanaka S, Hishiki H, Iijima Y, Ogata H, Fujishiro K, Tominaga T, Konno Y, Iwase Y, Endo M, Ishiwada N, Osone Y, Takemura R, Hamada H, Shimojo N.	Biosci Microbiota Food Health	10.12938/bmfh.2023-093	2024
Genetics	Development of a CRISPR-Cas12a system for efficient genome engineering in clostridia.	Zhang Y, Kubiak AM, Bailey TS, Claessen L, Hittmeyer P, Dubois L, Theys J, Lambin P.	Microbiol Spectr	10.1128/spectrum.02459-23	2023
	Effects of maternal and post-weaning supplementation with microbe-derived antioxidants on sow and piglet performance, oxidative status, and gut microbiota.	Tang J, Wang Y, Zhou Q, Fang Z, Lin Y, Xu S, Feng B, Zhuo Y, Jiang X, Zhao H, Wu, Che L.	Front Vet Sci	10.3389/fvets.2025.1574259	2025
	Erratum for Halpin et al., "Finished Whole-Genome Sequences of Clostridium butyricum Toxin Subtype E4 and Clostridium baratii Toxin Subtype F7 Strains".	Halpin JL, Hill K, Johnson SL, Bruce DC, Shirey TB, Dykes JK, Luquez C.	Genome Announc	10.1128/genomea.01050-17	2017
	Effects of Clostridium butyricum- and Bacillus spp.-Based Potential Probiotics on the Growth Performance, Intestinal Morphology, Immune Responses, and Caecal Microbiota in Broilers.	Zeng X, Li Q, Yang C, Yu Y, Fu Z, Wang H, Fan X, Yue M, Xu Y.	Antibiotics (Basel)	10.3390/antibiotics10060624	2021
	Effects of Wheat Bran and Clostridium butyricum Supplementation on Cecal Microbiota, Short-Chain Fatty Acid Concentration, pH and Histomorphometry in Broiler Chickens.	Molnar A, Such N, Farkas V, Pal L, Menyhart L, Wagner L, Husveth F, Dublecz K.	Animals (Basel)	10.3390/ani10122230	2020
	Effects of antibiotic therapy on the early development of gut microbiota and butyrate-producers in early infants.	Qiu J, Wu S, Huang R, Liao Z, Pan X, Zhao K, Peng Y, Xiang S, Cao Y, Ma Y, Xiao Z.	Front Microbiol	10.3389/fmicb.2024.1508217	2024
	Study on the Relationship between AAD and Clinical Features in Emergency Ward Patients and the Application Effect of Probiotics.	Qiu W, Bai F.	Contrast Media Mol Imaging	10.1155/2022/6164843	2022
	Structure-based clustering and mutagenesis of bacterial tannases reveals the importance and diversity of active site-capping domains.	Coleman T, Viknander S, Kirk AM, Sandberg D, Caron E, Zelezniak A, Krenske E, Larsbrink J.	Protein Sci	10.1002/pro.5202	2024
	Effect of adding Scutellaria baicalensis Georgi to feed on the microbial diversity in cattle feces.	Zhang J, Bai X, Li F, Na R, Ma Y, Liang X.	Front Microbiol	10.3389/fmicb.2025.1641802	2025
	Dietary Addition With Clostridium butyricum and Xylo-Oligosaccharides Improves Carcass Trait and Meat Quality of Huanjiang Mini-Pigs.	Cai Q, Hu C, Tang W, Jiang H, Geng M, Huang X, Kong X.	Front Nutr	10.3389/fnut.2021.748647	2021
	Comparative analysis of the postadmission and antemortem oropharyngeal and rectal swab microbiota of ICU patients.	Petrilla A, Nemeth P, Fauszt P, Szilagyi-Racz A, Mikolas M, Szilagyi-Tolnai E, David P, Stagel A, Gal F, Gal K, Sohajda R, Pham T, Stundl L, Biro S, Remenyik J, Paholcsek M.	Sci Rep	10.1038/s41598-024-78102-1	2024
	Structural basis of ssDNA-guided NADase activation of prokaryotic SPARTA system.	Hu R, Guo C, Liu X, Lin Y, Yang Z, Li Z, Yang Y, Ma E, Li Y, Chen J, Liu L.	Nucleic Acids Res	10.1093/nar/gkaf110	2025
	Effects of Coffee on Gut Microbiota and Bowel Functions in Health and Diseases: A Literature Review.	Saygili S, Hegde S, Shi XZ.	Nutrients	10.3390/nu16183155	2024
	Microbiome and cancer: from mechanistic implications in disease progression and treatment to development of novel antitumoral strategies.	Constantin M, Chifiriuc MC, Mihaescu G, Corcionivoschi N, Burlibasa L, Bleotu C, Tudorache S, Mitache MM, Filip R, Munteanu SG, Gradisteanu Pircalabioru G.	Front Immunol	10.3389/fimmu.2024.1373504	2024
	In vitro activity of fidaxomicin and combinations of fidaxomicin with other antibiotics against Clostridium perfringens strains isolated from dogs and cats.	Alvarez-Perez S, Anega B, Blanco JL, Hernandez M, Garcia ME.	BMC Vet Res	10.1186/s12917-023-03801-2	2023
Pathogenicity	The Oral Administration of Lactobacillus delbrueckii subsp. lactis 557 (LDL557) Ameliorates the Progression of Monosodium Iodoacetate-Induced Osteoarthritis.	Huang LW, Huang TC, Hu YC, Hsieh BS, Lin JS, Hsu HY, Lee CC, Chang KL.	Curr Issues Mol Biol	10.3390/cimb46080530	2024
	Therapeutic approaches targeting the gut microbiota in ischemic stroke: current advances and future directions.	Mao Z, Zhang J, Guo L, Wang X, Zhu Z, Miao M.	Biosci Microbiota Food Health	10.12938/bmfh.2024-022	2024
	Health benefits of butyrate and its producing bacterium, Clostridium butyricum, on aquatic animals.	Tran NT, Liang H, Li J, Deng T, Zhang M, Li S.	Fish Shellfish Immunol Rep	10.1016/j.fsirep.2023.100088	2023
	Effect of Clostridium butyricum Supplementation on in vitro Rumen Fermentation and Microbiota With High Grain Substrate Varying With Media pH Levels.	Jiao P, Wang Z, Wang X, Zuo Y, Yang Y, Hu G, Lu C, Xie X, Wang L, Yang W.	Front Microbiol	10.3389/fmicb.2022.912042	2022
Enzymology	Electrospun Solid Formulation of Anaerobic Gut Microbiome Bacteria.	Vass P, Pantea E, Domokos A, Hirsch E, Domjan J, Nemeth A, Molnar M, Feher C, Andersen SK, Vigh T, Verreck G, Csontos I, Marosi G, Nagy ZK.	AAPS PharmSciTech	10.1208/s12249-020-01769-y	2020
Phylogeny	Preeminent productivity of 1,3-propanediol by Clostridium butyricum JKT37 and the role of using calcium carbonate as pH neutraliser in glycerol fermentation.	Tee ZK, Jahim JM, Tan JP, Kim BH.	Bioresour Technol	10.1016/j.biortech.2017.02.110	2017
	The effect of autochthonous caproic acid-producing consortia inoculation on the multi-dimensional prokaryotic succession of bottom pitmud used for the Chinese strong-flavor Baijiu fermentation.	Zhang H, Zhen L, Chang Q, Liu Y, Xu K, Wang X, Cui L, Wu Z, Xue Z.	Curr Res Microb Sci	10.1016/j.crmicr.2025.100490	2025
	Enterococcus faecalis strains derived from wild bird provide protection against Clostridium perfringens challenge in locally-sourced broilers.	Zhang G, Zahra A, Yang T, Guo Q, Sun Y, Zhang Y, Gao Y, Zhang Y, Wang M, Gong J, Huang H, Wang Z, Wang C, Jiang Y.	Front Vet Sci	10.3389/fvets.2025.1601605	2025
Metabolism	Bile acids enhance fat metabolism and skeletal muscle development in Zhijiang duck by modulating gut microbiota.	Chen L, Zhang Z, Deng W, Jiang G, Xie D, Cao A.	Poult Sci	10.1016/j.psj.2025.105319	2025
Metabolism	Effect of Lactobacillus plantarum Extracellular Vesicles on Lipid Metabolism in Mice Fed a High-Fat Diet.	Xu SS, Yu CJ, Qin MY, Zhang Y, Jiang JP, Liu W, Pan Y, Zhang S, Zhao XY.	Mol Nutr Food Res	10.1002/mnfr.70183	2025
	The abundance of bifidobacterium in relation to visceral obesity and serum uric acid.	Gong H, Gao H, Ren Q, He J.	Sci Rep	10.1038/s41598-022-17417-3	2022
Enzymology	Glucose release kinetics of different feed ingredients and their impact on short-term growth of pigs by influencing carbon-nitrogen supply synchronization.	Huang M, Xue L, Wu Y, Sun Q, Xu Y, Li J, Yu X, Cao Y, Huang J, Zhang Z, Zhao J, Han D, Li D, Wang J.	J Anim Sci Biotechnol	10.1186/s40104-025-01198-6	2025
	Generating theranostic bacteria by depositing a protective visual therapeutic nanocoating via in situ sequential mineralization.	Chen S, Sun B, Lin L, Zhao X, Zhou Y, Wu F, Zhao H, Liu J.	Sci Adv	10.1126/sciadv.ady9183	2025
	Botulism Cases in Romania-An Overview of 14-Year National Surveillance Data.	Pauna AM, Craciun MD, Sirbu A, Popescu R, Enciu BG, Chivu CD, Simoiu M, Pitigoi D.	Biomedicines	10.3390/biomedicines12051058	2024
	Dietary Alpha-Ketoglutarate Supplementation Improves Bone Growth, Phosphorus Digestion, and Growth Performance in Piglets.	Tian J, Yang F, Bao X, Jiang Q, Li Y, Yao K, Yin Y.	Animals (Basel)	10.3390/ani13040569	2023
	Safety and efficacy of a feed additive consisting of Bacillus subtilis FERM BP-07462, Enterococcus lactis FERM BP-10867 and Clostridium butyricum FERM BP-10866 (BIO-THREE^®) for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, all avian species for rearing/fattening to slaughter and all avian species reared for laying or breeding to point of lay (TOA BIOPHARMA Co., Ltd.).	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Azimonti G, Bampidis V, Bastos ML, Christensen H, Dusemund B, Fasmon Durjava M, Kouba M, Lopez-Alonso M, Lopez Puente S, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Sanz Y, Villa RE, Woutersen R, Brantom P, Maradona MP, Tosti L, Anguita M, Brozzi R, Galobart J, Pizzo F, Revez J, Ortuno J, Tarres-Call J, Pettenati E.	EFSA J	10.2903/j.efsa.2022.7342	2022
	Characterization of Extracellular Vesicles from Streptococcus thermophilus 065 and Their Potential to Modulate the Immune Response.	Ortiz Camargo AR, van Mastrigt O, Gouw JW, Liu Y, Bongers RS, van Bergenhenegouwen J, Knol J, Abee T, Smid EJ.	Probiotics Antimicrob Proteins	10.1007/s12602-024-10422-0	2025
	Alleviating Clostridium perfringens-Induced Intestinal Lesions in Chickens Using the Xylanase CbXyn10C and Its Binary Cocktail with a Protease.	Zhang W, Hao Z, Yang D, Ji W, Guo K, Sun X, Wang S, Yang S, Ma J, Wang T, Luo H, Yao B, Zhang M, Wang Y, Huang H, Su X.	Animals (Basel)	10.3390/ani15020123	2025
	Dietary Supplementation with Fermented Milk Improves Growth Performance and Intestinal Functions in Intrauterine Growth-Restricted Piglets.	Yang Q, Cui L, Yang Y, Yang Y, Dai Z, Wu Z.	Animals (Basel)	10.3390/ani15101367	2025
	Changes in a glycerol-degrading bacterial community in an upflow anaerobic reactor for 1,3-propanediol production.	Cordeiro CN, Rojas P, Kato MT, Florencio L, Sanz JL.	Appl Microbiol Biotechnol	10.1007/s00253-025-13413-5	2025
Pathogenicity	The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice.	Liu J, Fu Y, Zhang H, Wang J, Zhu J, Wang Y, Guo Y, Wang G, Xu T, Chu M, Wang F.	Food Funct	10.1039/c7fo00355b	2017
Pathogenicity	Antioxidant Role of Probiotics in Inflammation-Induced Colorectal Cancer.	Hamamah S, Lobiuc A, Covasa M.	Int J Mol Sci	10.3390/ijms25169026	2024
Pathogenicity	Effects of ID-CBT5101 in Preventing and Alleviating Osteoarthritis Symptoms in a Monosodium Iodoacetate-Induced Rat Model.	Sim BY, Choi HJ, Kim MG, Jeong DG, Lee DG, Yoon JM, Kang DJ, Park S, Ji JG, Joo IH, Kim DH.	J Microbiol Biotechnol	10.4014/jmb.1803.03032	2018
Pathogenicity	Interactions between toll-like receptors signaling pathway and gut microbiota in host homeostasis.	Chen L, Zhang L, Hua H, Liu L, Mao Y, Wang R.	Immun Inflamm Dis	10.1002/iid3.1356	2024
	Gut bacterial species in late trimester of pregnant sows influence the occurrence of stillborn piglet through pro-inflammation response.	Chen Z, Yang H, Fu H, Wu L, Liu M, Jiang H, Liu Q, Wang Y, Xiong S, Zhou M, Sun X, Chen C, Huang L.	Front Immunol	10.3389/fimmu.2022.1101130	2022
	Clinical Significance of Probiotics for Children with Idiopathic Nephrotic Syndrome.	Yamaguchi T, Tsuji S, Akagawa S, Akagawa Y, Kino J, Yamanouchi S, Kimata T, Hashiyada M, Akane A, Kaneko K.	Nutrients	10.3390/nu13020365	2021
Metabolism	The effect of gut microbiota and probiotic organisms on the properties of extended spectrum beta-lactamase producing and carbapenem resistant Enterobacteriaceae including growth, beta-lactamase activity and gene transmissibility.	Kunishima H, Ishibashi N, Wada K, Oka K, Takahashi M, Yamasaki Y, Aoyagi T, Takemura H, Kitagawa M, Kaku M.	J Infect Chemother	10.1016/j.jiac.2019.04.021	2019
Pathogenicity	Clostridium butyricum Protects IPEC-J2 Cells from ETEC K88-Induced Oxidative Damage by Activating the Nrf2/ARE Signaling Pathway.	Dou C, Shang Z, Qiao J, Wang Y, Li H.	Oxid Med Cell Longev	10.1155/2021/4464002	2021
	The Gut Microbial Lipid Metabolite 14(15)-EpETE Inhibits Substance P Release by Targeting GCG/PKA Signaling to Relieve Cisplatin-Induced Nausea and Vomiting in Rats.	Lu M, Xie L, Yin S, Zhou J, Yi L, Ye L.	J Microbiol Biotechnol	10.4014/jmb.2403.03044	2024
	Comparative Analysis of Meat Quality and Hindgut Microbiota of Cultured and Wild Bighead Carp (Hypophthalmichthys nobilis, Richardson 1845) from the Yangtze River Area.	Muhammad AM, Yang C, Liu B, Sun C, Miao L, Zheng X, Pan L, Xia D, Zhou QL.	Microorganisms	10.3390/microorganisms13010020	2024
	SMC-like Wadjet system prevents plasmid transfer into Clostridium cellulovorans.	Schollkopf AI, Ehrenreich A, Liebl W.	Appl Microbiol Biotechnol	10.1007/s00253-025-13551-w	2025
	Colonization of Clostridium butyricum in Rats and Its Effect on Intestinal Microbial Composition.	Luo X, Kong Q, Wang Y, Duan X, Wang P, Li C, Huan Y.	Microorganisms	10.3390/microorganisms9081573	2021
Enzymology	Enhancing 1,3-Propanediol Productivity in the Non-Model Chassis Clostridium beijerinckii through Genetic Manipulation.	Bortolucci J, Guazzaroni ME, Schoch T, Durre P, Reginatto V.	Microorganisms	10.3390/microorganisms11071855	2023
	Impact of concomitant medications on the oncologic efficacy of systemic therapy in patients with advanced or metastatic urothelial carcinoma: a systematic review and meta-analysis.	Tsuboi I, Matsukawa A, Parizi MK, Miszczyk M, Fazekas T, Schulz RJ, Laukhtina E, Kawada T, Katayama S, Iwata T, Bekku K, Rajwa P, Wada K, Oberneder K, Chlosta P, Karakiewicz PI, Araki M, Shariat SF.	BMC Urol	10.1186/s12894-025-01754-2	2025
	Probiotics' Effects in the Treatment of Anxiety and Depression: A Comprehensive Review of 2014-2023 Clinical Trials.	Merkouris E, Mavroudi T, Miliotas D, Tsiptsios D, Serdari A, Christidi F, Doskas TK, Mueller C, Tsamakis K.	Microorganisms	10.3390/microorganisms12020411	2024
	Probiotics treatment ameliorated mycophenolic acid-induced colitis by enhancing intestinal barrier function and improving intestinal microbiota dysbiosis in mice.	Zhang P, Chen J, Ming Y, Niu Y.	Front Microbiol	10.3389/fmicb.2023.1153188	2023
	Microbiological Biodiversity of Regional Cow, Goat and Ewe Milk Cheeses Produced in Poland and Antibiotic Resistance of Lactic Acid Bacteria Isolated from Them.	Nalepa B, Markiewicz LH.	Animals (Basel)	10.3390/ani13010168	2022
	Dietary supplementation with blended essential oils improves meat quality of broilers through SCFA-mediated gut-muscle axis.	Malhi KK, Chen J, Wang TH, Huang MY, Xing KP, Xing HB, Song M, Kumar C, Zou XH, Li JL.	Poult Sci	10.1016/j.psj.2025.105911	2025
	Diversity of Clostridioides difficile PCR ribotypes isolated from freshwater sediments depends on the isolation method.	Rupnik M, Fuks A, Janezic S.	Appl Environ Microbiol	10.1128/aem.01442-24	2024
	The Effects of Enteral Nutrition on the Intestinal Environment in Patients in a Persistent Vegetative State.	Matsuoka H, Tochio T, Watanabe A, Funasaka K, Hirooka Y, Hartanto T, Togashi Y, Saito M, Nishimoto Y, Mizuguchi Y, Kumon M, Sakuragi C, Suda K, Hirose Y, Morita I.	Foods	10.3390/foods11040549	2022
	Advances in hyaluronic acid-based biomaterials: applications in cancer therapy, wound healing, and disease management.	Wang L, Zhou F, Xie W.	J Mater Sci Mater Med	10.1007/s10856-025-06946-8	2025
Pathogenicity	Unravelling three-way interactions between Clostridioides difficile, microbiota and the host.	Bywater-Brenna KK, Unnikrishnan M.	J Med Microbiol	10.1099/jmm.0.002067	2025
	Argonaute protein-based nucleic acid detection technology.	Wu Z, Yu L, Shi W, Ma J.	Front Microbiol	10.3389/fmicb.2023.1255716	2023
	A narrative review about cognitive impairment in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD): Another matter to face through a holistic approach.	Meroni M, Longo M, Paolini E, Dongiovanni P.	J Adv Res	10.1016/j.jare.2024.02.007	2025
	Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential.	Qu L, Li Y, Liu F, Fang Y, He J, Ma J, Xu T, Wang L, Lei P, Dong H, Jin L, Yang Q, Wu W, Sun D.	Aging Dis	10.14336/ad.2023.0823-2	2024
	Causal associations between constipation and pan-cancer: a bidirectional Mendelian randomization study.	Dang Y, He X, Liu X, Wang Y, Geng S, Cheng Y, Ma H, Zhao X.	Front Oncol	10.3389/fonc.2024.1428003	2024
Biotechnology	Harnessing Microbial Power for a Sustainable Future Food System.	Birgovan Rhazzali AL, Lakatos ES, Cioca LI, Paul NL, Vatca SD, Kis E, Pacurariu RL.	Microorganisms	10.3390/microorganisms13092217	2025
Metabolism	Selection and characterization of an anaerobic microbial consortium with high adaptation to crude glycerol for 1,3-propanediol production.	Zhou JJ, Shen JT, Jiang LL, Sun YQ, Mu Y, Xiu ZL.	Appl Microbiol Biotechnol	10.1007/s00253-017-8311-8	2017
Stress	Effect of the dietary probiotic Clostridium butyricum on growth, intestine antioxidant capacity and resistance to high temperature stress in kuruma shrimp Marsupenaeus japonicus.	Duan Y, Zhang Y, Dong H, Wang Y, Zhang J.	J Therm Biol	10.1016/j.jtherbio.2017.04.004	2017
Enzymology	Isolation and Characterization of Bacteriocin-Producing Lacticaseibacillus rhamnosus XN2 from Yak Yoghurt and Its Bacteriocin.	Wei Y, Wang J, Liu Z, Pei J, Brennan C, Abd El-Aty AM.	Molecules	10.3390/molecules27072066	2022
	Optimization of an economical medium composition for the coculture of Clostridium butyricum and Bacillus coagulans.	Li Y, Wang Y, Liu Y, Li X, Feng L, Li K.	AMB Express	10.1186/s13568-022-01354-5	2022
Enzymology	The B₁₂-independent glycerol dehydratase activating enzyme from Clostridium butyricum cleaves SAM to produce 5'-deoxyadenosine and not 5'-deoxy-5'-(methylthio)adenosine.	Walls WG, Moody JD, McDaniel EC, Villanueva M, Shepard EM, Broderick WE, Broderick JB.	J Inorg Biochem	10.1016/j.jinorgbio.2021.111662	2022
	Emerging innovative treatment strategies for advanced clear cell renal cell carcinoma.	Choi SH, Chen YW, Panian J, Yuen K, McKay RR.	Oncologist	10.1093/oncolo/oyae276	2025
Metabolism	2'-Fucosyllactose helps butyrate producers outgrow competitors in infant gut microbiota simulations.	Versluis DM, Schoemaker R, Looijesteijn E, Geurts JMW, Merks RMH.	iScience	10.1016/j.isci.2024.109085	2024
	Gut commensal bacterium Bacteroides vulgatus exacerbates helminth-induced cardiac fibrosis through succinate accumulation.	Wang J, Yin J, Liu X, Liu Y, Jin X.	PLoS Pathog	10.1371/journal.ppat.1013069	2025
Pathogenicity	Caenorhabditis elegans as a Convenient Animal Model for Microbiome Studies	Wu C, Davis S, Saudagar N, Shah S, Zhao W, Stern A, Martel J, Ojcius D, Yang H.	Int J Mol Sci		2024
Pathogenicity	Effects of Probiotics Lactobacillus reuteri and Clostridium butyricum on the Expression of Toll-like Receptors, Pro- and Anti-inflammatory Cytokines, and Antimicrobial Peptides in Broiler Chick Intestine.	Terada T, Nii T, Isobe N, Yoshimura Y.	J Poult Sci	10.2141/jpsa.0190098	2020
Pathogenicity	Viable Clostridium botulinum spores not detected in the household dust of major Canadian cities.	Harris RA, Blondin-Brosseau M, Levesque C, Rasmussen PE, Beauchemin S, Austin JW.	Epidemiol Infect	10.1017/s0950268823001474	2023
	Harnessing Probiotics to Combat Candidiasis: Mechanisms, Evidence, and Future Directions.	Wright E, Valand N, Venkatraman Girija U.	J Fungi (Basel)	10.3390/jof11110779	2025
Metabolism	Clostridium butyricum partially regulates the development of colitis-associated cancer through miR-200c.	Xiao Y, Dai X, Li K, Gui G, Liu J, Yang H.	Cell Mol Biol (Noisy-le-grand)	10.14715/cmb/2017.63.4.10	2017
	Use of eradication therapy in adjunction to periodontal therapy versus alone for treatment of Helicobacter pylori infections: a mini review.	Rahat M, Saqib M, Ahmed M, Suleman M, Ismail SM, Mumtaz H, Khalid H.	Ann Med Surg (Lond)	10.1097/ms9.0000000000000741	2023
	Commensal bacteria-derived extracellular vesicles suppress ulcerative colitis through regulating the macrophages polarization and remodeling the gut microbiota.	Liang L, Yang C, Liu L, Mai G, Li H, Wu L, Jin M, Chen Y.	Microb Cell Fact	10.1186/s12934-022-01812-6	2022
Pathogenicity	Does the Maternal Gut Microbiome Influence the Outcome of Perinatal Asphyxia?	Morozan VP, Ionescu MI, Zahiu CMD, Catrina AM, Racovita A, Chirila AT, Dogaru IA, Ciotei C, Pircalabioru GG, Zagrean AM.	Antioxidants (Basel)	10.3390/antiox14091134	2025
	Effects of Compound Probiotics on Cecal Microbiota and Metabolome of Swine.	Li J, Li H, Zhou Y, Xiang H, Lv M, Ruan B, Bo Z, Shen H, Xu F, Huang Y, Li L, Sun P.	Animals (Basel)	10.3390/ani13061006	2023
Genetics	Multi-spacer typing as an effective method to distinguish the clonal lineage of Clostridium butyricum strains isolated from stool samples during a series of necrotizing enterocolitis cases.	Benamar S, Cassir N, Merhej V, Jardot P, Robert C, Raoult D, La Scola B.	J Hosp Infect	10.1016/j.jhin.2016.10.026	2017
	The effects of candidate probiotic strains on the gut environment in dextran sulfate sodium-induced colitis mouse.	Ahn K, Baek KW, Yun K, Oh Y, Kim YS, Im E, Lee Y, Choi J, Song EJ, Park YS, Lee DH, Lee W, Lee DY, Han K, Ahn YJ.	Sci Rep	10.1038/s41598-025-03860-5	2025
	Safety and efficacy of the feed additive consisting of Clostridium butyricum FERM BP-2789 (Miya-Gold^® S) for chickens for fattening, chickens reared for laying, turkeys for fattening, turkeys reared for breeding, minor avian species (excluding laying birds), piglets (suckling and weaned) and minor porcine species (Miyarisan Pharmaceutical Co. Ltd.).	EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP), Bampidis V, Azimonti G, Bastos ML, Christensen H, Dusemund B, Kouba M, Kos Durjava M, Lopez-Alonso M, Lopez Puente S, Marcon F, Mayo B, Pechova A, Petkova M, Ramos F, Ramos F, Sanz Y, Villa RE, Woutersen R, Cocconcelli PS, Glandorf B, Herman L, Maradona MP, Saarela M, Anguita M, Galobart J, Holczknecht O, Manini P, Pizzo F, Tarres-Call J, Pettenati E.	EFSA J	10.2903/j.efsa.2021.6450	2021
	Simulated digestions of free oligosaccharides and mucin-type O-glycans reveal a potential role for Clostridium perfringens.	McDonald AG, Lisacek F.	Sci Rep	10.1038/s41598-023-51012-4	2024
Enzymology	Photoaffinity probe-enabled discovery of sennoside A reductase in Bifidobacterium pseudocatenulatum.	Xu Y, Lv S, Li X, Zhai C, Shi Y, Li X, Feng Z, Luo G, Wang Y, Gao X.	J Pharm Anal	10.1016/j.jpha.2024.101108	2025
	[Advances in the mechanism of probiotics on allergic diseases].	Qiao Y, Liu T.	Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi	10.13201/j.issn.1001-1781.2016.18.018	2016
	Effects of Dietary Supplementation with Protected Sodium Butyrate on Gut Microbiota in Growing-Finishing Pigs.	Bernad-Roche M, Belles A, Grasa L, Casanova-Higes A, Mainar-Jaime RC.	Animals (Basel)	10.3390/ani11072137	2021
	Clostridium butyricum Supplement Can Ameliorate the Intestinal Barrier Roles in Broiler Chickens Experimentally Infected With Clostridium perfringens.	Xu X, Yang S, Olajide JS, Qu Z, Gong Z, Wang J, Zhang Y, Wang H, Xiong L, Zhang K, Zhou E, Cai J.	Front Physiol	10.3389/fphys.2021.737481	2021
Enzymology	Denaturing Gradient Gel Electrophoresis Approach for Microbial Shift Analysis in Thermophilic and Mesophilic Anaerobic Digestions.	Pandey P, Chowdhury D, Wang Y.	Gels	10.3390/gels10050339	2024
Phylogeny	Dissecting and tracing the gut microbiota of infants with botulism: a cross sectional and longitudinal study.	Wang D, Li K, Wang L, Teng Z, Luo X, Sun H, Huang Y, Hu S, Xu X, He Z.	Front Microbiol	10.3389/fmicb.2024.1416879	2024
	Hydroxyapatite Fabrication for Enhancing Biohydrogen Production from Glucose Dark Fermentation.	Mo H, Wang N, Ma Z, Zhang J, Zhang J, Wang L, Dong W, Zang L.	ACS Omega	10.1021/acsomega.2c00059	2022
	Prevalence of Dietary Modification and Supplement Use in Patients with Metastatic Renal Cell Carcinoma Receiving Systemic Therapy.	Ebrahimi H, Battle D, Salgia NJ, Zengin ZB, Dizman N, Meza L, Bergerot CD, Barragan-Carrillo R, Hsu J, Castro D, Mercier B, Chawla N, Li X, Tripathi A, Liu ST, Chehrazi-Raffle A, Vaishampayan U, Staehler MD, Pal SK.	Nutrients	10.3390/nu16111630	2024
Biotechnology	Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder.	Huang F, Yang N, Zhang Q, Luo C, Wang J, Yang Y, Yue B, Chen P, Zhang X.	Foods	10.3390/foods14071181	2025
Pathogenicity	Transplant of microbiota from Crohn's disease patients to germ-free mice results in colitis.	Sheikh IA, Bianchi-Smak J, Laubitz D, Schiro G, Midura-Kiela MT, Besselsen DG, Vedantam G, Jarmakiewicz S, Filip R, Ghishan FK, Gao N, Kiela PR.	Gut Microbes	10.1080/19490976.2024.2333483	2024
	High-throughput screening of the effects of 90 xenobiotics on the simplified human gut microbiota model (SIHUMIx): a metaproteomic and metabolomic study	Castaneda-Monsalve V, Frohlich L, Haange S, Homsi M, Rolle-Kampczyk U, Fu Q, von Bergen M, Jehmlich N.	Front Microbiol		2024
	Study on the Nocardia seriolae Antagonistic Bacterium in the Gut Microbiota of Micropterus salmoides.	Xu S, Chen Q, Liu A, Chen S, Chen W, Qian S, Wang L, Chen Y.	Biology (Basel)	10.3390/biology14091128	2025
	Engineered Probiotics for the Management of Congenital Metabolic Diseases: A Systematic Review.	Barati M, Mosharkesh E, Tahmassian AH, Khodaei M, Jabbari M, Kalhori A, Alipour M, Ghavidel AA, Khalili-Moghadam S, Fathollahi A, Davoodi SH.	Prev Nutr Food Sci	10.3746/pnf.2024.29.1.1	2024
	Modulation of the Intestinal Microbiota by the Early Intervention with Clostridium Butyricum in Muscovy Ducks.	Xiao X, Fu Z, Li N, Yang H, Wang W, Lyu W.	Antibiotics (Basel)	10.3390/antibiotics10070826	2021
Metabolism	Effect of cassava pulp supplement on 1,3-propanediol production by Clostridium butyricum.	Apiwatanapiwat W, Vaithanomsat P, Tachaapaikoon C, Ratanakhanokchai K, Kosugi A.	J Biotechnol	10.1016/j.jbiotec.2016.05.016	2016
	Effect of dietary supplementation with Brevibacillus laterosporus on broiler growth performance, meat quality and gut microbiome.	Han H, Fu L, Wang J, Sun Y, Cao D, Lei Q, Zhou Y, Li F, Liu W, Li D, Hao D, Liu J.	Front Microbiol	10.3389/fmicb.2025.1608076	2025
	Cecum microbiota composition, fermentation characteristics, and immunometabolic biomarkers of Yunshang black goat fed varying dietary energy and protein levels.	Fu B, Zhao X, Khan M, Jiang Y, Li W, Mushtaq M, Danzeng B, Ni X, Azeem Z, Shao Q, Xue B, Ouyang Y.	Front Microbiol	10.3389/fmicb.2025.1523586	2025
	Dietary Quercetin Supplementation Attenuates Diarrhea and Intestinal Damage by Regulating Gut Microbiota in Weanling Piglets.	Xu B, Qin W, Xu Y, Yang W, Chen Y, Huang J, Zhao J, Ma L.	Oxid Med Cell Longev	10.1155/2021/6221012	2021
Pathogenicity	Necrotizing Enterocolitis: A Comprehensive Review on Toll-like Receptor 4-Mediated Pathophysiology, Clinical, and Therapeutic Insights.	Ishiyama A, Jang HS, Dintaman JM, Duess JW, Tragesser C, Sodhi CP.	Biomedicines	10.3390/biomedicines13092288	2025
	Novel Acylated Naringin Enhances Propionate Release and Stimulates the Growth of Flavanone-Metabolizing Bacteria in an In Vitro Batch Fermentation Model.	Ruiz-Alvarez BE, Padilla-de la Rosa JD, Gonzalez Avila M, Sandoval G, Desjardins Y.	Life (Basel)	10.3390/life15060967	2025
	Potential of natural products and gut microbiome in tumor immunotherapy.	Cao L, Wang X, Ma X, Xu M, Li J.	Chin Med	10.1186/s13020-024-01032-7	2024
	Fusobacterium nucleatum-induced imbalance in microbiome-derived butyric acid levels promotes the occurrence and development of colorectal cancer.	Wu QL, Fang XT, Wan XX, Ding QY, Zhang YJ, Ji L, Lou YL, Li X.	World J Gastroenterol	10.3748/wjg.v30.i14.2018	2024
	Effects of Probiotic Supplementation on Body Weight, Growth Performance, Immune Function, Intestinal Microbiota and Metabolites in Fallow Deer.	Wang M, Guo Q, Shan Y, Cheng Z, Zhang Q, Bai J, Dong Y, Zhong Z.	Biology (Basel)	10.3390/biology13080603	2024
	Effect of dietary Clostridium butyricum on growth, intestine health status and resistance to ammonia stress in Pacific white shrimp Litopenaeus vannamei.	Duan Y, Zhang Y, Dong H, Wang Y, Zheng X, Zhang J.	Fish Shellfish Immunol	10.1016/j.fsi.2017.03.048	2017
Metabolism	Inhibited growth of Clostridium butyricum in efficient H₂-producing co-culture with Rhodobacter sphaeroides.	Laurinavichene T, Laurinavichius K, Shastik E, Tsygankov A.	Appl Microbiol Biotechnol	10.1007/s00253-016-7977-7	2016
	Effect of Additional Clostridium butyricum on the Intestinal Flora of Chronic Hepatitis B Patients Treated with Entecavir.	Lu YX, Chang YZ, Liang P, Yang CQ.	Infect Dis Ther	10.1007/s40121-021-00463-1	2021
	Exploring the role of gut microbiota in Parkinson's disease: insights from fecal microbiota transplantation.	Guo M, Gao H, Wang Y, Xiang Y.	Front Neurosci	10.3389/fnins.2025.1574512	2025
	Effect of Dietary Clostridium butyricum Supplementation on Growth Performance, Intestinal Barrier Function, Immune Function, and Microbiota Diversity of Pekin Ducks.	Liu Y, Liu C, An K, Gong X, Xia Z.	Animals (Basel)	10.3390/ani11092514	2021
	Pregabalin Attenuates Carboplatin-Induced Akathisia-Like Neuropathy: A Novel Case Report.	Saito Y, Takekuma Y, Furuta M, Sugawara M.	Case Rep Oncol	10.1159/000518776	2021
	Gene expression dynamics in Bacillus cereus and Bacillus subtilis treated with Thymus vulgaris and Origanum vulgare subsp. hirtum essential oils.	Anniballi F, Purgatorio C, Serio A, Scalfaro C, Taglieri S, Paparella A.	Front Microbiol	10.3389/fmicb.2025.1643608	2025
	Human intestinal organoids as models to study enteric bacteria and viruses.	Adeniyi-Ipadeola G, Nwanosike H, Ramani S.	Curr Opin Microbiol	10.1016/j.mib.2023.102362	2023
	Effects of Synbiotic Supplementation on Bone and Metabolic Health in Caucasian Postmenopausal Women: Rationale and Design of the OsteoPreP Trial.	Turbic A, Vandenput L, Gandham A, Lorentzon M.	Nutrients	10.3390/nu16234219	2024
	The Complex Interplay between the Gut Microbiome and Osteoarthritis: A Systematic Review on Potential Correlations and Therapeutic Approaches.	Marchese L, Contartese D, Giavaresi G, Di Sarno L, Salamanna F.	Int J Mol Sci	10.3390/ijms25010143	2023
	Galleria mellonella as an in vivo model for assessing the protective activity of probiotics against gastrointestinal bacterial pathogens.	Scalfaro C, Iacobino A, Nardis C, Franciosa G.	FEMS Microbiol Lett	10.1093/femsle/fnx064	2017
	Kinetic modeling and microbial community analysis for high-rate biohydrogen production using a dynamic membrane.	Park JH, Sim YB, Kumar G, Anburajan P, Park JH, Park HD, Kim SH.	Bioresour Technol	10.1016/j.biortech.2018.04.070	2018
	Exercise Affects Mucosa-Associated Microbiota and Colonic Tumor Formation Induced by Azoxymethane in High-Fat-Diet-Induced Obese Mice.	Yo S, Matsumoto H, Gu T, Sasahira M, Oosawa M, Handa O, Umegaki E, Shiotani A.	Microorganisms	10.3390/microorganisms12050957	2024
Pathogenicity	Integrated multi-omics analysis of the microbial profile characteristics associated with pulmonary arterial hypertension in congenital heart disease.	Xie J, Zhang X, Cheng L, Deng Y, Ren H, Mu M, Zhao L, Mu C, Chen J, Liu K, Ma R.	Microbiol Spectr	10.1128/spectrum.01808-24	2024
	Effect of Solid-State Fermentation Products of Lactobacillus plantarum, Candida utilis, and Bacillus coagulans on Growth Performance of Broilers and Prevention of Avian Colibacillosis.	Li F, Lv B, Zuo J, Nawaz S, Wang Z, Lian L, Yin H, Chen S, Han X, Wang H.	Vet Sci	10.3390/vetsci11100468	2024
	Readily available drugs and other interventions to potentially improve the efficacy of immune checkpoint blockade in cancer.	Coleman M, Mascialino SJ, Panjwani A, Edwards E, Sukhatme VV, Gavegnano C, Sukhatme VP.	Front Immunol	10.3389/fimmu.2023.1281744	2023
	Exploring the gut microbiota of healthy captive Asian elephants from various locations in Yunnan, China.	Wang Y, Wang Y, Zhou J, Bao M, Shah T, Yang S, Zheng J, Li Q, Hou Y, Wang B, Yuan R.	Front Microbiol	10.3389/fmicb.2024.1403930	2024
Pathogenicity	Intestinal Microbiota in Experimental Acute Kidney Injury.	Shah N, Rabb H.	Nephron	10.1159/000526265	2023
	Clostridioides difficile infection is associated with differences in transcriptionally active microbial communities.	Chen See JR, Leister J, Wright JR, Kruse PI, Khedekar MV, Besch CE, Kumamoto CA, Madden GR, Stewart DB, Lamendella R.	Front Microbiol	10.3389/fmicb.2024.1398018	2024
	Finished Whole-Genome Sequences of Clostridium butyricum Toxin Subtype E4 and Clostridium baratii Toxin Subtype F7 Strains.	Halpin JL, Hill K, Johnson SL, Bruce DC, Shirey TB, Dykes JK, Luquez C.	Genome Announc	10.1128/genomea.00375-17	2017
Pathogenicity	Effect of Brassica rapa L. Polysaccharide on Lewis Lung Cancer Mice by Inflammatory Regulation and Gut Microbiota Modulation.	Du C, Zhao Y, Shen F, Qian H.	Foods	10.3390/foods13223704	2024
Pathogenicity	The impact of bacillus pumilus TS2 isolated from yaks on growth performance, gut microbial community, antioxidant activity, and cytokines related to immunity and inflammation in broilers.	Guo C, Liu S, Di L, Tang S.	Front Vet Sci	10.3389/fvets.2024.1383262	2024
	Clostridium butyricum MIYAIRI 588-Induced Protectin D1 Has an Anti-inflammatory Effect on Antibiotic-Induced Intestinal Disorder.	Ariyoshi T, Hagihara M, Eguchi S, Fukuda A, Iwasaki K, Oka K, Takahashi M, Yamagishi Y, Mikamo H.	Front Microbiol	10.3389/fmicb.2020.587725	2020
	A review on the potential use of eubiotics in non-chicken poultry species.	Mnisi CM, Njeri FM, Maina AN, Waliaula PK, Cheng V, Kumalo I, Egbu CF, Kiarie EG.	Trop Anim Health Prod	10.1007/s11250-025-04466-9	2025
	Mechanistic insights into the pleiotropic effects of butyrate as a potential therapeutic agent on NAFLD management: A systematic review.	Amiri P, Arefhosseini S, Bakhshimoghaddam F, Jamshidi Gurvan H, Hosseini SA.	Front Nutr	10.3389/fnut.2022.1037696	2022
Enzymology	A (S)-3-Hydroxybutyrate Dehydrogenase Belonging to the 3-Hydroxyacyl-CoA Dehydrogenase Family Facilitates Hydroxyacid Degradation in Anaerobic Bacteria.	Zhou Y, Wei Y, Jiang L, Zhang Y, Jiao X.	Appl Environ Microbiol	10.1128/aem.00366-23	2023
	Correlation of distribution characteristics and dynamic changes of gut microbiota with the efficacy of immunotherapy in EGFR-mutated non-small cell lung cancer.	Luo WC, Mei SQ, Huang ZJ, Chen ZH, Zhang YC, Yang MY, Liu JQ, Xu JY, Yang XR, Zhong RW, Tang LB, Yin LX, Deng Y, Peng YL, Lu C, Chen BL, Ke DX, Tu HY, Yang JJ, Xu CR, Wu YL, Zhou Q.	J Transl Med	10.1186/s12967-024-05135-5	2024
	Metformin-Associated Gastrointestinal Adverse Events Are Reduced by Probiotics: A Meta-Analysis.	Szymczak-Pajor I, Drzewoski J, Wenclewska S, Sliwinska A.	Pharmaceuticals (Basel)	10.3390/ph17070898	2024
Phylogeny	Linking growth performance and carcass traits with enterotypes in Muscovy ducks.	Fan Q, Xu Y, Xiao Y, Yang C, Lyu W, Yang H.	Anim Biosci	10.5713/ab.23.0482	2024
	Optimisation of cultivation conditions for Bacillus velezensis G7 from mangrove plants and exploration of potential bacteriocins.	Li Y, Ma H, Pan R, Long Y, Zhao Y, Yu M, Peng J, Ma Y.	Front Pharmacol	10.3389/fphar.2025.1530043	2025
	Programmable cleavage of linear double-stranded DNA by combined action of Argonaute CbAgo from Clostridium butyricum and nuclease deficient RecBC helicase from E. coli.	Vaiskunaite R, Vainauskas J, Morris JJL, Potapov V, Bitinaite J.	Nucleic Acids Res	10.1093/nar/gkac229	2022
	Akkermansia muciniphila outer membrane protein regulates recruitment of CD8⁺ T cells in lung adenocarcinoma and through JAK-STAT signalling pathway.	Xu Y, Tan X, Yang Q, Fang Z, Chen W.	Microb Biotechnol	10.1111/1751-7915.14522	2024
	Clostridium butyricum protects intestinal barrier function via upregulation of tight junction proteins and activation of the Akt/mTOR signaling pathway in a mouse model of dextran sodium sulfate-induced colitis.	Liu M, Xie W, Wan X, Deng T.	Exp Ther Med	10.3892/etm.2020.9138	2020
	In situ carbon dioxide capture to co-produce 1,3-propanediol, biohydrogen and micro-nano calcium carbonate from crude glycerol by Clostridium butyricum.	Wang XL, Zhou JJ, Liu S, Sun YQ, Xiu ZL.	Biotechnol Biofuels Bioprod	10.1186/s13068-022-02190-2	2022
	Royal Jelly Enhances the Social Status of Submissive Rats by Restoring Balance to the Disturbed Gut-Brain Communication.	Zhu F, Xu J, Wang T, Yang R, He B, Wang HL, Xu Y.	Foods	10.3390/foods14050819	2025
	Complete genome sequence of Clostridium butyricum JKY6D1 isolated from the pit mud of a Chinese flavor liquor-making factory.	Li C, Wang Y, Xie G, Peng B, Zhang B, Chen W, Huang X, Wu H, Zhang B.	J Biotechnol	10.1016/j.jbiotec.2016.01.003	2016
Transcriptome	Combining transcriptomic and metabolomic insights into carbohydrate utilization by Ruminiclostridium papyrosolvens DSM2782.	You M, Ren Z, Ye L, Zhao Q, Liu Z, Song H, Xu C.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02619-4	2025
	Recent Advancements in Metal-Organic Framework-Based Microfluidic Chips for Biomedical Applications.	Kidanemariam A, Cho S.	Micromachines (Basel)	10.3390/mi16070736	2025
Phylogeny	The role of the vaginal microbiome in distinguishing female chronic pelvic pain caused by endometriosis/adenomyosis.	Chao X, Liu Y, Fan Q, Shi H, Wang S, Lang J.	Ann Transl Med	10.21037/atm-20-4586	2021
Metabolism	Probiotic pasta consumption improves lipid metabolism and reduces gut permeability in overweight and obese adults: a randomized controlled trial.	Tagliamonte S, Barone Lumaga R, De Filippis F, Valentino V, Aponte M, Romano R, Vitaglione P.	Curr Res Food Sci	10.1016/j.crfs.2025.101215	2025
	Effects of Chinese herbal medicine on colorectal adenoma recurrence following polypectomy: a systematic review and meta-analysis.	Cheng Y, Di YM, May B, Zhang AL, Xue CC, Zhang B.	Front Pharmacol	10.3389/fphar.2025.1460900	2025
	Effects of clostridium butyricum and bifidobacterium on BTLA expression on CD4⁺ T cells and lymphocyte differentiation in late preterm infants.	Zhang SF, Tang ZS, Tong L, Tao XX, Suo QF, Xu XM.	Microb Pathog	10.1016/j.micpath.2016.09.008	2016
Metabolism	Supplemental Clostridium butyricum Modulates Lipid Metabolism Through Shaping Gut Microbiota and Bile Acid Profile of Aged Laying Hens.	Wang WW, Wang J, Zhang HJ, Wu SG, Qi GH.	Front Microbiol	10.3389/fmicb.2020.00600	2020
	The bibliometric analysis of research on traditional Chinese medicine regulating gut microbiota for cancer treatment from 2014 to 2024	Lei Y, Shan Y, Zhou D, Chen C.	Hereditas		2025
	Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy.	Romick-Rosendale LE, Legomarcino A, Patel NB, Morrow AL, Kennedy MA.	Metabolomics	10.1007/s11306-013-0546-5	2014
Metabolism	Development of a specific fluorescent phage endolysin for in situ detection of Clostridium species associated with cheese spoilage.	Gomez-Torres N, Dunne M, Garde S, Meijers R, Narbad A, Avila M, Mayer MJ.	Microb Biotechnol	10.1111/1751-7915.12883	2018
Pathogenicity	Effect of Probiotic Clostridium butyricum NCTC 7423 Supernatant on Biofilm Formation and Gene Expression of Bacteroides fragilis.	Shin DS, Rhee KJ, Eom YB	J Microbiol Biotechnol	10.4014/jmb.2001.01027	2020
Metabolism	Enhancement of fermentative hydrogen production from Spirogyra sp. by increased carbohydrate accumulation and selection of the biomass pretreatment under a biorefinery model.	Pinto T, Gouveia L, Ortigueira J, Saratale GD, Moura P	J Biosci Bioeng	10.1016/j.jbiosc.2018.02.017	2018
	Reduced catabolic protein expression in Clostridium butyricum DSM 10702 correlate with reduced 1,3-propanediol synthesis at high glycerol loading.	Gungormusler-Yilmaz M, Shamshurin D, Grigoryan M, Taillefer M, Spicer V, Krokhin OV, Sparling R, Levin DB	AMB Express	10.1186/s13568-014-0063-6	2014
Genetics	Genome Sequence of Clostridium butyricum Strain DSM 10702, a Promising Producer of Biofuels and Biochemicals.	Xin B, Tao F, Wang Y, Gao C, Ma C, Xu P	Genome Announc	10.1128/genomeA.00563-13	2013
Metabolism	Microbial conversion of glycerol to 1,3-propanediol: physiological comparison of a natural producer, Clostridium butyricum VPI 3266, and an engineered strain, Clostridium acetobutylicum DG1(pSPD5).	Gonzalez-Pajuelo M, Meynial-Salles I, Mendes F, Soucaille P, Vasconcelos I	Appl Environ Microbiol	10.1128/AEM.72.1.96-101.2006	2006
Metabolism	Hydrogen production from glucose by anaerobes.	Ogino H, Miura T, Ishimi K, Seki M, Yoshida H	Biotechnol Prog	10.1021/bp050224r	2005
Metabolism	Metabolic engineering of Clostridium acetobutylicum for the industrial production of 1,3-propanediol from glycerol.	Gonzalez-Pajuelo M, Meynial-Salles I, Mendes F, Andrade JC, Vasconcelos I, Soucaille P	Metab Eng	10.1016/j.ymben.2005.06.001	2005
Biotechnology	Production of 1,3-Propanediol by Clostridium butyricum VPI 3266 in continuous cultures with high yield and productivity.	Gonzalez-Pajuelo M, Andrade JC, Vasconcelos I	J Ind Microbiol Biotechnol	10.1007/s10295-005-0012-0	2005
Metabolism	Production of 1,3-propanediol by Clostridium butyricum VPI 3266 using a synthetic medium and raw glycerol.	Gonzalez-Pajuelo M, Andrade JC, Vasconcelos I	J Ind Microbiol Biotechnol	10.1007/s10295-004-0168-z	2004
Metabolism	Regulation of carbon and electron flow in Clostridium butyricum VPI 3266 grown on glucose-glycerol mixtures.	Saint-Amans S, Girbal L, Andrade J, Ahrens K, Soucaille P	J Bacteriol	10.1128/JB.183.5.1748-1754.2001	2001
Enzymology	Molecular analysis of the malR gene of Clostridium butyricum NCIMB 7423, a member of the LacI-GalR family of repressor proteins.	Goda SK, Eisa O, Akhter M, Minton NP	FEMS Microbiol Lett	10.1111/j.1574-6968.1998.tb13146.x	1998
Enzymology	Molecular analysis of a Clostridium butyricum NCIMB 7423 gene encoding 4-alpha-glucanotransferase and characterization of the recombinant enzyme produced in Escherichia coli.	Goda SK, Eissa O, Akhtar M, Minton NP	Microbiology (Reading)	10.1099/00221287-143-10-3287	1997
Metabolism	Phosphatidylserine decarboxylase from Clostridium butyricum.	Verma JN, Goldfine H	J Lipid Res	S0022-2275(20)34348-0	1985
Metabolism	Heterologous Gene Regulation in Clostridia: Rationally Designed Gene Regulation for Industrial and Medical Applications.	Zhang Y, Bailey TS, Kubiak AM, Lambin P, Theys J	ACS Synth Biol	10.1021/acssynbio.2c00401	2022
Phylogeny	Inconstantimicrobium mannanitabidum sp. nov., a novel member of the family Clostridiaceae isolated from anoxic soil under the treatment of reductive soil disinfestation.	Ueki A, Tonouchi A, Honma S, Kaku N, Ueki K.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006748	2025
Biotechnology	Clostridium caseinilyticum sp. nov., a close relative of Clostridium tepidum and Clostridium sporogenes, isolated from spoiled cheese and silage.	Shani N, Zago M, Berthoud H, Marzohl D, Michellod E, Gindro K, Giraffa G, Arias-Roth E.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006875	2025
Phylogeny	Clostridium vitabionis sp. nov., isolated from the large intestine of a mini-pig.	Shin Y, Paek J, Kim H, Kook JK, Chang YH	Int J Syst Evol Microbiol	10.1099/ijsem.0.004694	2021
Phylogeny	Description of Absiella argi gen. nov., sp. nov., and transfer of Eubacterium dolichum and Eubacterium tortuosum to the genus Absiella as Absiella dolichum comb. nov. and Absiella tortuosum comb. nov.	Paek J, Shin Y, Kim JS, Kim H, Kook JK, Paek WK, Chang YH	Anaerobe	10.1016/j.anaerobe.2017.07.006	2017

References

#4045	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 10702
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#33296	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

Rate our new design

Content

About us

Clostridium butyricum (DSM 10702, ATCC 19398, IAM 14194)

Name and taxonomic classification

Morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite production

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_014131795

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

Help

Social Media