Granulicatella adiacens (DSM 9848, ATCC 49175, CIP 103243)

Name: Granulicatella adiacens (DSM 9848, ATCC 49175, CIP 103243)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 2274

Type strain

Strain Designation GaD

Culture col. no. DSM 9848 ATCC 49175 CIP 103243 CCUG 27637 A CCUG 27809 1 more

NCBI tax ID(s) 638301 46124

Special Collections DSMZ CCUG CIP

History <- A. Bouvet, GaD <- J.F. Acar CIP <- 1988, A. Bouvet, Hôtel-Dieu Hosp., Paris, France: strain GaD, Streptococcus adjacens <- P. Cayeux, Inst. Pasteur, Paris, France <- J. Acar, Broussais Hosp., France

Links

Granulicatella adiacens GaD is an anaerobe, mesophilic, Gram-positive prokaryote that was isolated from Aortic valve.

Gram-positive coccus-shaped anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 10348

LMG 14496,CIP 103243,ATCC 49175,DSM 9848,CCUG 27809,CCM 4671,CIP 103.243,KCTC 3661,NCTC 13000,CCUG 27637 A

@ref 20215

Last LPSN update 2025-12-16 09:47:16

Domain Bacillati

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Carnobacteriaceae

Genus Granulicatella

Species Granulicatella adiacens

Full scientific name Granulicatella adiacens corrig. (Bouvet et al. 1989) Collins and Lawson 2000

Synonyms (2)

Abiotrophia adiacens
Streptococcus adjacens

BacDive ID	Other strains from **Granulicatella adiacens** (87)	Type strain
135896	G. adiacens G40, CIP 103898
135897	G. adiacens C28, CIP 103899
139116	G. adiacens C50, CIP 103896
139118	G. adiacens L61, CIP 103897
139119	G. adiacens CIP 103900, LAM 22
139120	G. adiacens J18, CIP 103901
142760	G. adiacens CCUG 14485 A
142954	G. adiacens CCUG 15899
144688	G. adiacens CCUG 26229
145175	G. adiacens
145176	G. adiacens CCUG 27810
145177	G. adiacens CCUG 27811
145178	G. adiacens CCUG 27812
145179	G. adiacens CCUG 27813
145180	G. adiacens CCUG 27814
145181	G. adiacens CCUG 27815
145191	G. adiacens CCUG 27856 A
145445	G. adiacens CCUG 28567
145756	G. adiacens CCUG 29509
145799	G. adiacens CCUG 29632
145800	G. adiacens CCUG 29633
146010	G. adiacens CCUG 30154
146214	G. adiacens CCUG 30618
146310	G. adiacens CCUG 30864
146356	G. adiacens CCUG 31003
146751	G. adiacens CCUG 32066
146992	G. adiacens CCUG 32612
147152	G. adiacens CCUG 32957 A
147326	G. adiacens CCUG 33372
147536	G. adiacens CCUG 33761
147716	G. adiacens CCUG 34072
148065	G. adiacens CCUG 34754
148271	G. adiacens CCUG 35130 B
148275	G. adiacens CCUG 35135
148329	G. adiacens CCUG 35231
149238	G. adiacens CCUG 37320
149278	G. adiacens CCUG 37398
149728	G. adiacens CCUG 38287
150059	G. adiacens CCUG 38932
150182	G. adiacens CCUG 39211
150240	G. adiacens CCUG 39360
150577	G. adiacens CCUG 41643
150744	G. adiacens CCUG 42154
150750	G. adiacens CCUG 42168
150875	G. adiacens CCUG 42606
151126	G. adiacens CCUG 43328
151243	G. adiacens CCUG 43530
151329	G. adiacens CCUG 43771 B
151568	G. adiacens CCUG 44351
151595	G. adiacens CCUG 44406
151596	G. adiacens CCUG 44407
151597	G. adiacens CCUG 44408
151684	G. adiacens CCUG 44629
151725	G. adiacens CCUG 44717
151853	G. adiacens CCUG 45052
152040	G. adiacens CCUG 45624
152160	G. adiacens CCUG 45933
152499	G. adiacens CCUG 46942
152532	G. adiacens CCUG 47012
152627	G. adiacens CCUG 47230
152628	G. adiacens CCUG 47231
152912	G. adiacens CCUG 47974
153088	G. adiacens CCUG 48446 B
153175	G. adiacens CCUG 48647
153203	G. adiacens CCUG 48713
153348	G. adiacens CCUG 49307
153742	G. adiacens CCUG 50833
153817	G. adiacens CCUG 51263
153902	G. adiacens CCUG 51571
154206	G. adiacens CCUG 52752
154453	G. adiacens CCUG 53680
154493	G. adiacens CCUG 53861 B
154584	G. adiacens CCUG 54473
154790	G. adiacens CCUG 55193
155237	G. adiacens CCUG 57022
155239	G. adiacens CCUG 57036
155240	G. adiacens CCUG 57047
155329	G. adiacens CCUG 57347
155693	G. adiacens CCUG 59016
155773	G. adiacens CCUG 59275
156223	G. adiacens CCUG 60768
156253	G. adiacens CCUG 60877
156303	G. adiacens CCUG 61107
156365	G. adiacens CCUG 61304
156366	G. adiacens CCUG 61305
170968	G. adiacens CIMB 04-8880, CRBIP17.75
170969	G. adiacens CIMB 04-8246, CRBIP17.76

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
116044	positive	coccus-shaped
125438				90.479

Colony morphology

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
3743	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)	Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
40610	MEDIUM 27 - for Capnocytophaga gingivalis and Abiotrophia genus		Distilled water make up to (489.000 ml);Horse serum (200.000 ml);Brain heart infusion (37.000 g);Maltose 10 % solution - M0173 (200.000 ml);Cysteine hydrochloride 5% solution - M0172 (111.000 ml)
116044	CIP Medium 27	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
3743	positive	growth	37	mesophilic
40610	positive	growth	37
48956	positive	growth	37
116044	positive	growth	30-37	mesophilic
116044	negative	growth	5
116044	negative	growth	10

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
3743	anaerobe
48956	anaerobe
48956	microaerophile
116044	facultative anaerobe
125439	microaerophile	92.7

Halophily

@ref	Salt	Growth	Tested relation	Concentration
116044	NaCl		growth	6.5 %

Murein

@ref	Murein short key	Type
3743	A11.04	A3alpha L-Lys-L-Ala

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	+	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
116044	4853 ChEBI	esculin	-	hydrolysis
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	+	builds acid from	from API 50CH acid
116044	606565 ChEBI	hippurate	-	hydrolysis
68371	15443 ChEBI	inulin	+	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	+	builds acid from	from API 50CH acid
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
116044	17632 ChEBI	nitrate	-	reduction
116044	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	+	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68371	32528 ChEBI	turanose	+	builds acid from	from API 50CH acid
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test	Voges-proskauer-test
116044	15688 ChEBI	acetoin		-
68380	35581 ChEBI	indole	-		from API rID32A

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
116044	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68380	alpha-galactosidase	-	3.2.1.22	from API rID32A
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68380	alpha-glucosidase	-	3.2.1.20	from API rID32A
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	-	3.2.1.23	from API zym
116044	beta-galactosidase	+	3.2.1.23
68380	beta-galactosidase	-	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	-	3.2.1.21	from API zym
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
116044	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	-		from API zym
116044	gamma-glutamyltransferase	-	2.3.2.2
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	histidine arylamidase	+		from API rID32A
68380	L-arginine arylamidase	+		from API rID32A
68382	leucine arylamidase	-	3.4.11.1	from API zym
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68382	lipase (C 14)	-		from API zym
116044	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
116044	ornithine decarboxylase	-	4.1.1.17
116044	oxidase	-
68380	proline-arylamidase	+	3.4.11.5	from API rID32A
68380	serine arylamidase	+		from API rID32A
68382	trypsin	+	3.4.21.4	from API zym
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	+		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	gluconeogenesis	100	8 of 8
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	palmitate biosynthesis	100	22 of 22
66794	folate polyglutamylation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	pentose phosphate pathway	90.91	10 of 11
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	glycine betaine biosynthesis	80	4 of 5
66794	starch degradation	80	8 of 10
66794	threonine metabolism	80	8 of 10
66794	photosynthesis	78.57	11 of 14
66794	aspartate and asparagine metabolism	77.78	7 of 9
66794	ppGpp biosynthesis	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	acetate fermentation	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	cardiolipin biosynthesis	71.43	5 of 7
66794	phenylalanine metabolism	69.23	9 of 13
66794	purine metabolism	67.02	63 of 94
66794	acetoin degradation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	formaldehyde oxidation	66.67	2 of 3
66794	pyrimidine metabolism	62.22	28 of 45
66794	vitamin B1 metabolism	61.54	8 of 13
66794	degradation of hexoses	61.11	11 of 18
66794	methylglyoxal degradation	60	3 of 5
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	myo-inositol biosynthesis	60	6 of 10
66794	glycogen metabolism	60	3 of 5
66794	Entner Doudoroff pathway	60	6 of 10
66794	glycolysis	58.82	10 of 17
66794	propanol degradation	57.14	4 of 7
66794	CO2 fixation in Crenarchaeota	55.56	5 of 9
66794	d-mannose degradation	55.56	5 of 9
66794	oxidative phosphorylation	53.85	49 of 91
66794	adipate degradation	50	1 of 2
66794	methionine metabolism	50	13 of 26
66794	ethanol fermentation	50	1 of 2
66794	ribulose monophosphate pathway	50	1 of 2
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	50	4 of 8
66794	lactate fermentation	50	2 of 4
66794	sulfopterin metabolism	50	2 of 4
66794	suberin monomers biosynthesis	50	1 of 2
66794	degradation of pentoses	50	14 of 28
66794	phenylmercury acetate degradation	50	1 of 2
66794	isoleucine metabolism	50	4 of 8
66794	glutamate and glutamine metabolism	50	14 of 28
66794	degradation of sugar acids	48	12 of 25
66794	metabolism of disaccharids	45.45	5 of 11
66794	d-xylose degradation	45.45	5 of 11
66794	valine metabolism	44.44	4 of 9
66794	serine metabolism	44.44	4 of 9
66794	degradation of sugar alcohols	43.75	7 of 16
66794	mevalonate metabolism	42.86	3 of 7
66794	tetrahydrofolate metabolism	42.86	6 of 14
66794	ubiquinone biosynthesis	42.86	3 of 7
66794	isoprenoid biosynthesis	42.31	11 of 26
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	propionate fermentation	40	4 of 10
66794	arachidonate biosynthesis	40	2 of 5
66794	cellulose degradation	40	2 of 5
66794	ethylmalonyl-CoA pathway	40	2 of 5
66794	glycine metabolism	40	4 of 10
66794	lipoate biosynthesis	40	2 of 5
66794	non-pathway related	39.47	15 of 38
66794	cysteine metabolism	38.89	7 of 18
66794	phosphatidylethanolamine bioynthesis	38.46	5 of 13
66794	alanine metabolism	37.93	11 of 29
66794	ketogluconate metabolism	37.5	3 of 8
66794	vitamin B6 metabolism	36.36	4 of 11
66794	citric acid cycle	35.71	5 of 14
66794	glutathione metabolism	35.71	5 of 14
66794	tryptophan metabolism	34.21	13 of 38
66794	lipid A biosynthesis	33.33	3 of 9
66794	IAA biosynthesis	33.33	1 of 3
66794	chorismate metabolism	33.33	3 of 9
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	flavin biosynthesis	33.33	5 of 15
66794	octane oxidation	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	ascorbate metabolism	31.82	7 of 22
66794	urea cycle	30.77	4 of 13
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	sulfate reduction	30.77	4 of 13
66794	leucine metabolism	30.77	4 of 13
66794	4-hydroxyphenylacetate degradation	30	3 of 10
66794	lipid metabolism	29.03	9 of 31
66794	reductive acetyl coenzyme A pathway	28.57	2 of 7
66794	tyrosine metabolism	28.57	4 of 14
66794	chlorophyll metabolism	27.78	5 of 18
66794	histidine metabolism	27.59	8 of 29
66794	proline metabolism	27.27	3 of 11
66794	arginine metabolism	25	6 of 24
66794	CMP-KDO biosynthesis	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	lysine metabolism	23.81	10 of 42
66794	arachidonic acid metabolism	22.22	4 of 18
66794	nitrate assimilation	22.22	2 of 9

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
116044	-	+	+	-	-	-	-	-	+	-	-	+	-	-	-	-	-	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
116044	not determinedn.d.	+/-	-	-	-	-	-	-	+/-	-	-	+	+	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	+	-	-	+	-	+	-	-	+	+	-	-	+	-	+	-	+	-	-	-	-	+/-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
3743	-	-	-	-	-	-	-	-	-	-	+	+	-	+/-	-	-	-	+	+	-	+	+	+/-	+	+	+	+	+/-	+
3743	-	-	-	-	-	-	-	-	-	-	+/-	+/-	-	+	-	-	-	+	+	-	+/-	+/-	-	+	+	+	+	-	+
3743	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	+	-	+/-	+	-	+	-	+/-	+	-	+

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
116044	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host Body-Site	#Organ	#Heart
#Host	#Human	-
#Host Body Product	#Fluids	#Blood
#Infection	#Inflammation	-
#Infection	#Patient	-

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
3743	Aortic valve
48859	Human cardiac valves,endocarditis
48956	Human blood,endocarditis	France	FRA	Europe
116044	Human, Aortic valves

Taxonmaps

69479

Global distribution of 16S sequence D50540 (>99% sequence identity) for Granulicatella adiacens subclade from Microbeatlas

Aquatic Samples	5374
Soil Samples	3152
Animal Samples	155545
Plant Samples	1511
Total Samples	165582

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
3743	2	Risk group (German classification) According to TRBA 466
116044	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM2515056v1 assembly for Granulicatella adiacens ATCC 49175	complete	GCA_025150565	638301.55	8118837370	638301	99.13
124043	ASM1993100v1 assembly for Granulicatella adiacens FDAARGOS_1477	complete	GCA_019931005	46124.66	8065213633	46124	97.96
66792	Granulicatella adiacens strain FDAARGOS_1477	complete		46124.71		46124	95.63
66792	Granulicatella adiacens strain FDAARGOS_1477	complete		46124.72		46124	95.63
66792	Granulicatella adiacens strain FDAARGOS_1477	complete		46124.67		46124	95.63
66792	ASM16067v1 assembly for Granulicatella adiacens ATCC 49175	scaffold	GCA_000160675	638301.3	645951817	638301	73.36

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Granulicatella adiacens strain ATCC 49175 16S-23S ribosomal RNA intergenic spacer, complete sequence	AY353083	222	638301
3743	Granulicatella adiacens gene for 16S rRNA, strain: GIFU12706	D50540	1406	46124
124043	Granulicatella adiacens strain DSM 9848 16S ribosomal RNA gene, partial sequence 16S-23S ribosomal RNA intergenic spacer, complete sequence and 23S ribosomal RNA gene, partial sequence.	MK330556	4251	46124
124043	Granulicatella adiacens strain DSM 9848 16S ribosomal RNA gene, partial sequence.	MK330514	1282	46124

GC content

@ref	GC-content (mol%)	Method
3743	36.6	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Granulicatella adiacens strain FDAARGOS_1477
PATRIC: 46124.66

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	73.00	no
125439	motility	BacteriaNetⓘ	yes	66.20	no
125439	gram_stain	BacteriaNetⓘ	variable	74.80	no
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	92.70	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Granulicatella adiacens ATCC 49175 ATCC 49175
NCBI: GCA_025150565.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	87.06	no
125438	anaerobic	anaerobicⓘ	no	76.28	no
125438	aerobic	aerobicⓘ	no	96.12	yes
125438	spore-forming	spore-formingⓘ	no	84.09	no
125438	thermophilic	thermophileⓘ	no	95.88	yes
125438	flagellated	motile2+ⓘ	no	90.48	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	The Evaluation of the Effects of Two Probiotic Strains on the Oral Ecosystem: A Randomized Clinical Trial.	Volgenant CMC, van der Waal SV, Brandt BW, Buijs MJ, van der Veen MH, Rosema NAM, Fiebich BL, Rose T, Schmitter T, Gajfulin M, Crielaard W, Zaura E.	Front Oral Health	10.3389/froh.2022.825017	2022
	An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis-Time to Change Paradigm?	Pagotto A, Campanile F, Conti P, Prataviera F, Della Siega P, Flammini S, Giuliano S, Martini L, Pecori D, Sartor A, Screm M, Semenzin T, Tascini C.	Infect Dis Rep	10.3390/idr16020020	2024
	Draft Genome Sequence of Granulicatella sp. Strain S8, Isolated from a Marine Fish, Seriola quinqueradiata.	Lee M, Farooq A, Jeong JB, Jung MY.	Microbiol Resour Announc	10.1128/mra.01352-22	2023
	Enhanced propagation of Granulicatella adiacens from human oral microbiota by hyaluronan.	Yabuuchi S, Oiki S, Minami S, Takase R, Watanabe D, Hashimoto W.	Sci Rep	10.1038/s41598-022-14857-9	2022
Phylogeny	Use of groESL as a target for identification of Abiotrophia, Granulicatella, and Gemella species.	Hung WC, Tseng SP, Chen HJ, Tsai JC, Chang CH, Lee TF, Hsueh PR, Teng LJ.	J Clin Microbiol	10.1128/jcm.00787-10	2010
Transcriptome	Gene expression of bacterial collagenolytic proteases in root caries.	Dame-Teixeira N, Parolo CCF, Maltz M, Rup AG, Devine DA, Do T.	J Oral Microbiol	10.1080/20002297.2018.1424475	2018
	Comparative Metatranscriptomics of Periodontitis Supports a Common Polymicrobial Shift in Metabolic Function and Identifies Novel Putative Disease-Associated ncRNAs.	Ram-Mohan N, Meyer MM.	Front Microbiol	10.3389/fmicb.2020.00482	2020
	Laboratory Diagnosis of 37 Cases of Bartonella Endocarditis Based on Enzyme Immunoassay and Real-Time PCR.	Shapira L, Rasis M, Binsky Ehrenreich I, Maor Y, Katchman EA, Treves A, Velan A, Halutz O, Graidy-Varon M, Leibovitch C, Maisler N, Ephros M, Giladi M.	J Clin Microbiol	10.1128/jcm.02217-20	2021
Metabolism	Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome.	Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA.	Cell	10.1016/j.cell.2023.05.037	2023
Genetics	New Insight into Antimicrobial Compounds from Food and Marine-Sourced Carnobacterium Species through Phenotype and Genome Analyses.	Begrem S, Ivaniuk F, Gigout-Chevalier F, Kolypczuk L, Bonnetot S, Leroi F, Grovel O, Delbarre-Ladrat C, Passerini D.	Microorganisms	10.3390/microorganisms8071093	2020
Phylogeny	Bloodstream and endovascular infections due to Abiotrophia defectiva and Granulicatella species.	Senn L, Entenza JM, Greub G, Jaton K, Wenger A, Bille J, Calandra T, Prod'hom G.	BMC Infect Dis	10.1186/1471-2334-6-9	2006
Metabolism	Metagenomic analysis of nitrate-reducing bacteria in the oral cavity: implications for nitric oxide homeostasis.	Hyde ER, Andrade F, Vaksman Z, Parthasarathy K, Jiang H, Parthasarathy DK, Torregrossa AC, Tribble G, Kaplan HB, Petrosino JF, Bryan NS.	PLoS One	10.1371/journal.pone.0088645	2014
Pathogenicity	Spatial Ecology of the Human Tongue Dorsum Microbiome.	Wilbert SA, Mark Welch JL, Borisy GG.	Cell Rep	10.1016/j.celrep.2020.02.097	2020
Phylogeny	Identification of clinically relevant viridans streptococci by an oligonucleotide array.	Chen CC, Teng LJ, Kaiung S, Chang TC.	J Clin Microbiol	10.1128/jcm.43.4.1515-1521.2005	2005
	Design, construction, and in vivo augmentation of a complex gut microbiome.	Cheng AG, Ho PY, Aranda-Diaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA.	Cell	10.1016/j.cell.2022.08.003	2022
Pathogenicity	Real-time PCR assay for detection of fluoroquinolone resistance associated with grlA mutations in Staphylococcus aureus.	Lapierre P, Huletsky A, Fortin V, Picard FJ, Roy PH, Ouellette M, Bergeron MG.	J Clin Microbiol	10.1128/jcm.41.7.3246-3251.2003	2003
Phylogeny	Insight into the evolution of the histidine triad protein (HTP) family in Streptococcus.	Shao ZQ, Zhang YM, Pan XZ, Wang B, Chen JQ.	PLoS One	10.1371/journal.pone.0060116	2013
	Integrative View of the Diversity and Evolution of SWEET and SemiSWEET Sugar Transporters.	Jia B, Zhu XF, Pu ZJ, Duan YX, Hao LJ, Zhang J, Chen LQ, Jeon CO, Xuan YH.	Front Plant Sci	10.3389/fpls.2017.02178	2017
Biotechnology	Sequence analysis of Leuconostoc mesenteroides bacteriophage Phi1-A4 isolated from an industrial vegetable fermentation.	Lu Z, Altermann E, Breidt F, Kozyavkin S.	Appl Environ Microbiol	10.1128/aem.02126-09	2010
Enzymology	Use of tuf sequences for genus-specific PCR detection and phylogenetic analysis of 28 streptococcal species.	Picard FJ, Ke D, Boudreau DK, Boissinot M, Huletsky A, Richard D, Ouellette M, Roy PH, Bergeron MG.	J Clin Microbiol	10.1128/jcm.42.8.3686-3695.2004	2004
Enzymology	Rapid concentration and molecular enrichment approach for sensitive detection of Escherichia coli and Shigella species in potable water samples.	Maheux AF, Bissonnette L, Boissinot M, Bernier JL, Huppe V, Picard FJ, Berube E, Bergeron MG.	Appl Environ Microbiol	10.1128/aem.02337-10	2011
Enzymology	Diversity of anaerobic microbes in spacecraft assembly clean rooms.	Probst A, Vaishampayan P, Osman S, Moissl-Eichinger C, Andersen GL, Venkateswaran K.	Appl Environ Microbiol	10.1128/aem.02167-09	2010
Metabolism	Metabolic Modeling of Cystic Fibrosis Airway Communities Predicts Mechanisms of Pathogen Dominance.	Henson MA, Orazi G, Phalak P, O'Toole GA.	mSystems	10.1128/msystems.00026-19	2019
Phylogeny	Molecular characterization of subject-specific oral microflora during initial colonization of enamel.	Diaz PI, Chalmers NI, Rickard AH, Kong C, Milburn CL, Palmer RJ, Kolenbrander PE.	Appl Environ Microbiol	10.1128/aem.72.4.2837-2848.2006	2006
	The Effect of Benzyl Isothiocyanate on the Expression of Genes Encoding NADH Oxidase and Fibronectin-Binding Protein in Oral Streptococcal Biofilms.	Alhandal H, Almesaileikh E, Bhardwaj RG, Al Khabbaz A, Karched M.	Front Oral Health	10.3389/froh.2022.863723	2022
	Proteomic Analysis and Virulence Assessment of Granulicatella adiacens Secretome.	Karched M, Bhardwaj RG, Tiss A, Asikainen S.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00104	2019
	Coaggregation and biofilm growth of Granulicatella spp. with Fusobacterium nucleatum and Aggregatibacter actinomycetemcomitans.	Karched M, Bhardwaj RG, Asikainen SE.	BMC Microbiol	10.1186/s12866-015-0439-z	2015
Metabolism	Proteomics of extracellular vesicles produced by Granulicatella adiacens, which causes infective endocarditis.	Alkandari SA, Bhardwaj RG, Ellepola A, Karched M	PLoS One	10.1371/journal.pone.0227657	2020
Metabolism	Cytokine induction of peripheral blood mononuclear cells by biofilms and biofilm supernatants of Granulicatella and Abiotrophia spp.	Bhardwaj RG, Al-Khabbaz A, Karched M	Microb Pathog	10.1016/j.micpath.2017.11.037	2017
Pathogenicity	Granulicatella and Abiotrophia species from human clinical specimens.	Christensen JJ, Facklam RR	J Clin Microbiol	10.1128/JCM.39.10.3520-3523.2001	2001
	Granulicatella seriolae sp. nov., a Novel Facultative Anaerobe Isolated from Yellowtail Marine Fish.	Lee M, Choi YJ, Farooq A, Jeong JB, Jung MY.	Curr Microbiol	10.1007/s00284-023-03523-6	2023

References

#3743	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 9848
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#40610	; Curators of the CIP;
#48859	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 27637 A
#48956	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 27809
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#68371	Automatically annotated from API 50CH acid .
#68380	Automatically annotated from API rID32A .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#116044	Collection of Institut Pasteur ; Curators of the CIP; CIP 103243
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Granulicatella adiacens (DSM 9848, ATCC 49175, CIP 103243)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Halophily

Murein

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

Pathway annotation

API zym

API 50CHac

API rID32A

API biotype100

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_025150565

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

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