Mycobacterium tuberculosis H37Rv is a prokaryote that was isolated from Human.
SI-ID 15077
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Last LPSN update
2026-02-09 11:42:03 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Mycobacteriales |
| Family Mycobacteriaceae |
| Genus Mycobacterium |
| Species Mycobacterium tuberculosis |
| Full scientific name Mycobacterium tuberculosis (Zopf 1883) Lehmann and Neumann 1896 (Approved Lists 1980) |
| Synonyms (8) |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Metabolism | Chlorhexidine decontamination of sputum for culturing Mycobacterium tuberculosis. | Asmar S, Drancourt M. | BMC Microbiol | 10.1186/s12866-015-0479-4 | 2015 |  |
| Investigating the Molecular Mechanism and Function of the Histidine Kinase TrcS in Mycobacterium tuberculosis. | Liu D, Li N, Song H, Yao W. | ACS Omega | 10.1021/acsomega.5c09240 | 2025 | | |
| Real-time evaluation of macozinone activity against Mycobacterium tuberculosis through bacterial nanomotion analysis. | Vocat A, Luraschi-Eggemann A, Antoni C, Cathomen G, Cichocka D, Greub G, Riabova O, Makarov V, Opota O, Mendoza A, Cole ST, Sturm A. | Antimicrob Agents Chemother | 10.1128/aac.01318-24 | 2025 | | |
| Lung epithelial injury impairs early host immune responses to Mycobacterium tuberculosis. | Miao X, Li X, He Z, Xu G, Li Y, Wang Y, Wu J, Wu Q, Chen H. | Inflamm Res | 10.1007/s00011-025-02106-4 | 2025 | | |
| Thienopyrimidine amide analogs target MmpL3 in Mycobacterium tuberculosis. | Baldin VP, Harding CL, Quach D, Sugie J, Pogliano J, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.00980-25 | 2025 | | |
| Proteome | Detection and accurate identification of Mycobacterium species by flow injection tandem mass spectrometry (FIA-MS/MS) analysis of mycolic acids. | Rafal S, Magdalena D, Karol M, Bartlomiej S, Konrad K. | Sci Rep | 10.1038/s41598-025-96867-x | 2025 | |
| Pathogenicity | High-throughput screening of small molecules targeting Mycobacterium tuberculosis in human iPSC macrophages. | Armesilla-Diaz A, Pilar Arenaz M, Ashby C, Blanco D, D'Oria E, Garuti H, Gomez V, Gonzalez-Del-Rio R, Martinez-Hoyos M, Meiler E, Mendoza-Losana A, Mohamet L, Padron-Barthe L, Perez E, Perez L, Remuinan MJ, Rodriguez-Miquel B, Segura-Carro D, Viera-Morilla S. | Antimicrob Agents Chemother | 10.1128/aac.01613-24 | 2025 | |
| Common Biological Properties of Mycobacterium tuberculosis MmpL3 Inhibitors. | Ames L, Allen R, Boshoff HIM, Cleghorn LAT, Engelhart CA, Schnappinger D, Parish T. | ACS Infect Dis | 10.1021/acsinfecdis.5c00394 | 2025 | | |
| An arylsulfonamide that targets cell wall biosynthesis in Mycobacterium tuberculosis. | Allen R, Ames L, Baldin VP, Butts A, Henry KJ, Durst G, Quach D, Sugie J, Pogliano J, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.01037-24 | 2024 | | |
| Design of a multi-epitope vaccine against drug-resistant mycobacterium tuberculosis and mycobacterium bovis using reverse vaccinology. | Akurut E, Gavamukulya Y, Mulindwa J, Isiagi M, Galiwango R, Bbuye M, Lujumba I, Kiberu D, Nabisubi P, Kebirungi G, Kambugu A, Castelnuovo B, Nkurunungi G, Jjingo D, Oketch B, Kateete DP, Mboowa G. | Sci Rep | 10.1038/s41598-025-11768-3 | 2025 | | |
| Pathogenicity | Mycobacterium tuberculosis uses intrinsically disordered, fast evolving proteins to interact with conserved host factors. | Pozzoli U, Forni D, Arrigoni F, Cagliani R, De Gioia L, Sironi M. | Genome Biol | 10.1186/s13059-025-03854-6 | 2025 | |
| Genetics | Genomic Insight into Primary Adaptation of Mycobacterium tuberculosis to Aroylhydrazones and Nitrofuroylamides In Vitro. | Mokrousov I, Angelova VT, Slavchev I, Bezruchko MV, Dimitrov S, Polev DE, Dobrikov GM, Valcheva V. | Antibiotics (Basel) | 10.3390/antibiotics14030225 | 2025 | |
| Antioxidant, antibacterial and antiviral effects of the combination of ginger and garlic extracts. | Rajendrasozhan S. | Bioinformation | 10.6026/973206300200011 | 2024 | | |
| The impact of physiological state and environmental stress on bacterial load estimation methodologies for Mycobacterium tuberculosis. | Maitra A, Wijk M, Margaryan H, Denti P, McHugh TD, Kloprogge F. | Sci Rep | 10.1038/s41598-024-74318-3 | 2024 | | |
| Triazolopyrimidines Target Aerobic Respiration in Mycobacterium tuberculosis. | Shelton C, McNeil M, Allen R, Flint L, Russell D, Berube B, Korkegian A, Ovechkina Y, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.02041-21 | 2022 | | |
| Metabolism | Heterogeneous fitness landscape cues, pknG low expression, and phthiocerol dimycocerosate low production of Mycobacterium tuberculosis ATCC25618 rpoB S450L in enriched broth. | Rodriguez-Beltran E, Lopez GD, Anzola JM, Rodriguez-Castillo JG, Carazzone C, Murcia MI. | Tuberculosis (Edinb) | 10.1016/j.tube.2021.102156 | 2022 | |
| Transcriptome | Comparative Transcriptomics Reveal Differential Expression of Coding and Non-Coding RNAs in Clinical Strains of Mycobacterium tuberculosis. | Mvubu NE, Govender D, Pillay M. | Int J Mol Sci | 10.3390/ijms26010217 | 2024 | |
| Impact of Mycobacterium tuberculosis H37Rv Infection on Extracellular Vesicle Cargo in Macrophages: Implications for Host-Pathogen Interaction. | Salgado-Cantu MG, Gutierrez-Gonzalez LH, Guzman-Beltran S, Herrera MT, Sarabia C, Gonzalez Y. | Microorganisms | 10.3390/microorganisms12122405 | 2024 | | |
| Glucomannan is a promising isoniazid's enhancer that inducing macrophage phagocytosis. | Novita BD, Wasiyastuti W, Tjahjono Y, Wijaya H, Hadinugroho W, Wijaya S, Soegianto L, Theodora I, Widoretno ETW, Samsudin K, Julian A. | J Adv Pharm Technol Res | 10.4103/japtr.japtr_96_24 | 2024 | | |
| Metabolism | Usnic acid impacts energy production and iron metabolism in Mycobacterium tuberculosis H37Rv. | Sawicki R, Zabost A, Jankowski G, Augustynowicz-Kopec E, Truszkiewicz W, Sieniawska E. | mSystems | 10.1128/msystems.00256-25 | 2025 | |
| Epidemiology of drug-resistant tuberculosis among hospitalized children with tuberculosis in southwest China, 2017-2024. | Wang DM, An Q, Yang Q, Liao Y. | Front Microbiol | 10.3389/fmicb.2025.1609146 | 2025 | | |
| A vaccine targeting lung resident-memory CD4+ T cell phenotype protects against Mycobacterium tuberculosis in mice. | Ko KH, Baek SH, Bae HS, Kim YM, Gu SH, Jung YY, Kwak EH, Choi HG, Kim HJ, Shim TS, Kim DH, Bin Cha S. | NPJ Vaccines | 10.1038/s41541-025-01225-7 | 2025 | | |
| Pathogenicity | Impact of Methylthioxylose Substituents on the Biological Activities of Lipomannan and Lipoarabinomannan in Mycobacterium tuberculosis. | Palcekova Z, De K, Angala SK, Gilleron M, Zuberogoitia S, Gouxette L, Soto-Ojeda M, Gonzalez-Juarrero M, Obregon-Henao A, Nigou J, Wheat WH, Jackson M. | ACS Infect Dis | 10.1021/acsinfecdis.4c00079 | 2024 | |
| Antigenic sites in SARS-CoV-2 spike RBD show molecular similarity with pathogenic antigenic determinants and harbors peptides for vaccine development. | Dakal TC. | Immunobiology | 10.1016/j.imbio.2021.152091 | 2021 | | |
| Synthesis of New Thiazole Clubbed Imidazo[2,1-b]thiazole Hybrid as Antimycobacterial Agents. | Mahmoud HK, Sayed AR, Abdel-Aziz MM, Gomha SM. | Med Chem | 10.2174/1573406418666220413095854 | 2022 | | |
| Cell-autonomous targeting of arabinogalactan by host immune factors inhibits mycobacterial growth. | Qin L, Xu J, Chen J, Wang S, Zheng R, Cui Z, Liu Z, Wu X, Wang J, Huang X, Wang Z, Wang M, Pan R, Kaufmann SHE, Meng X, Zhang L, Sha W, Liu H. | Elife | 10.7554/elife.92737 | 2024 | | |
| Enzymology | Immunoinformatics and structural aided approach to develop multi-epitope based subunit vaccine against Mycobacterium tuberculosis. | Sethi G, Varghese RP, Lakra AK, Nayak SS, Krishna R, Hwang JH. | Sci Rep | 10.1038/s41598-024-66858-5 | 2024 | |
| High-Performance Detection of Mycobacterium bovis in Milk Using Recombinase-Aided Amplification-Clustered Regularly Interspaced Short Palindromic Repeat-Cas13a-Lateral Flow Detection. | Wang J, Wang N, Xu L, Zeng X, Cheng J, Zhang X, Zhang Y, Yin D, Gou J, Pan X, Zhu X. | Foods | 10.3390/foods13111601 | 2024 | | |
| Bedaquiline, Delamanid, Linezolid, Clofazimine, and Capreomycin MIC Distributions for Drug Resistance Mycobacterium tuberculosis in Shanghai, China. | Guo Y, Yang J, Wang W, Wu X, Wan B, Wang H, Sha W, Yu F. | Infect Drug Resist | 10.2147/idr.s440711 | 2023 | | |
| Simultaneous detection and differentiation of Mycobacterium tuberculosis and nontuberculous mycobacteria coexisting in patients with pulmonary tuberculosis by single-tube multiplex PCR. | Heidari L, Rafiei Dehbidi G, Farhadi A, Kashkooli GS, Zarghampoor F, Namdari S, Seyyedi N, Fard SA, Behzad-Behbahani A. | Iran J Microbiol | 10.18502/ijm.v15i3.12900 | 2023 | | |
| Integration of multi-modal measurements identifies critical mechanisms of tuberculosis drug action. | Johnson WC, Alivisatos A, Smith TC, Van N, Soni V, Wallach JB, Clark NA, Fitzgerald TA, Whiteley JJ, Tan S, Sokolov A, Ando DM, Schnappinger D, Rhee KY, Aldridge BB. | Cell Syst | 10.1016/j.cels.2025.101348 | 2025 | | |
| Susceptibility of beta-Lactam Antibiotics and Genetic Mutation of Drug-Resistant Mycobacterium tuberculosis Isolates in Korea. | Park S, Jung J, Kim J, Han SB, Ryoo S. | Tuberc Respir Dis (Seoul) | 10.4046/trd.2021.0175 | 2022 | | |
| Antitubercular activity of 2-mercaptobenzothiazole derivatives targeting Mycobacterium tuberculosis type II NADH dehydrogenase. | Saha P, Sau S, Kalia NP, Sharma DK. | RSC Med Chem | 10.1039/d4md00118d | 2024 | | |
| The new thiazolidine-2,4-dione-based hybrids with promising antimycobacterial activity: design, synthesis, biological evaluation, and drug interaction analysis. | Trotsko N, Glogowska A, Kapron B, Koziel K, Augustynowicz-Kopec E, Paneth A. | J Enzyme Inhib Med Chem | 10.1080/14756366.2024.2442703 | 2025 | | |
| Drug resistant Mycobacterium tuberculosis strains have altered cell envelope hydrophobicity that influences infection outcomes in human macrophages. | Schami A, Islam MN, Wall M, Hicks A, Meredith R, Kreiswirth B, Mathema B, Belisle JT, Torrelles JB. | Sci Rep | 10.1038/s41598-024-81457-0 | 2024 | | |
| Broad-Spectrum In Vitro Activity of Nalpha-Aroyl-N-Aryl-Phenylalanine Amides against Non-Tuberculous Mycobacteria and Comparative Analysis of RNA Polymerases. | Lang M, Ganapathy US, Abdelaziz R, Dick T, Richter A. | Antibiotics (Basel) | 10.3390/antibiotics13050404 | 2024 | | |
| Synthesis and Antimycobacterial Assays of Some New Ethambutol Analogs. | Abdelaziz R, Dube M, Mann L, Richter A, Robaa D, Reiling N, Abdel-Halim M, Imming P. | Molecules | 10.3390/molecules30030600 | 2025 | | |
| Menthol- and thymol-based ciprofloxacin derivatives against Mycobacterium tuberculosis: in vitro activity, lipophilicity, and computational studies. | Szulczyk D, Wozinski M, Kolinski M, Kmiecik S, Glogowska A, Augustynowicz-Kopec E, Dobrowolski MA, Roszkowski P, Struga M, Ciura K. | Sci Rep | 10.1038/s41598-023-43708-4 | 2023 | | |
| Intercellular mosaic methylation in fast-growing Mycobacterium tuberculosis clinical isolates. | Ahmadi Jeshvaghane M, Modlin SJ, Conkle-Gutierrez D, Espinoza ME, Valafar F. | NAR Mol Med | 10.1093/narmme/ugae020 | 2024 | | |
| A comprehensive update to the Mycobacterium tuberculosis H37Rv reference genome. | Chitale P, Lemenze AD, Fogarty EC, Shah A, Grady C, Odom-Mabey AR, Johnson WE, Yang JH, Eren AM, Brosch R, Kumar P, Alland D. | Nat Commun | 10.1038/s41467-022-34853-x | 2022 | | |
| A New Beginning to the Existing Medicines; Repurposing FDA-Approved Drugs for the Neglected Re-Emerging Disease Leptospirosis. | Christie SAD, Hariharan S, Chakraborti S, Srinivasan N, Madanan MG. | ACS Omega | 10.1021/acsomega.4c02535 | 2024 | | |
| Epidemiology of Nontuberculous Mycobacteria in Tuberculosis suspects, Southwest of China, 2017-2022. | Wang DM, Liu H, Zheng YL, Xu YH, Liao Y. | Front Cell Infect Microbiol | 10.3389/fcimb.2023.1282902 | 2023 | | |
| Immuno-informatics voyage through molecular mimicry of Heat Shock Proteins: Potential IBD immunopathogenesis. | Alem M, Abtahi Froushani SM, Hajighahramani N, Hosseini-Asl S, Pourfarzi F, Nemati R. | PLoS One | 10.1371/journal.pone.0333618 | 2025 | | |
| Dynamic Measurement of Protein Translation in Mycobacteria Using Nontargeted Stable Isotope Labeling in Combination with MALDI-TOF Mass Spectrometry-Based Readout. | Haisch C, Neumann-Cip AC, Imhof A, Schmidt A, Forne I, Hoelscher M, Wieser A. | Anal Chem | 10.1021/acs.analchem.4c03931 | 2025 | | |
| Herp regulates intracellular survival of Mycobacterium tuberculosis H37Ra in macrophages by regulating reactive oxygen species-mediated autophagy. | Son S-H, Lee J, Cho S-N, Choi J-A, Kim J, Nguyen TD, Lee S-A, Son D, Song C-H. | mBio | 10.1128/mbio.01535-23 | 2023 | | |
| Benzene Amide Ether Scaffold is Active against Non-replicating and Intracellular Mycobacterium tuberculosis. | Ahmed S, Chowdhury S, Gomez J, Hung DT, Parish T. | ACS Infect Dis | 10.1021/acsinfecdis.3c00275 | 2023 | | |
| Pathogenicity | InhA inhibitors have activity against non-replicating Mycobacterium tuberculosis. | Flint L, Korkegian A, Parish T. | PLoS One | 10.1371/journal.pone.0239354 | 2020 | |
| The mycobacterial glycoside hydrolase LamH enables capsular arabinomannan release and stimulates growth. | Franklin A, Salgueiro VC, Layton AJ, Sullivan R, Mize T, Vazquez-Iniesta L, Benedict ST, Gurcha SS, Anso I, Besra GS, Banzhaf M, Lovering AL, Williams SJ, Guerin ME, Scott NE, Prados-Rosales R, Lowe EC, Moynihan PJ. | Nat Commun | 10.1038/s41467-024-50051-3 | 2024 | | |
| Specific Cationic Antimicrobial Peptides Enhance the Recovery of Low-Load Quiescent Mycobacterium tuberculosis in Routine Diagnostics. | Bull TJ, Munshi T, Lopez-Perez PM, Tran AC, Cosgrove C, Bartolf A, Menichini M, Rindi L, Parigger L, Malanovic N, Lohner K, Wang CJH, Fatima A, Martin LL, Esin S, Batoni G, Hilpert K. | Int J Mol Sci | 10.3390/ijms242417555 | 2023 | | |
| Novel quinoline-piperazine hybrids: the design, synthesis and evaluation of antibacterial and antituberculosis properties. | Gnanavelu K, K S VK, Eswaran S, Sivashanmugam K. | RSC Med Chem | 10.1039/d2md00260d | 2023 | | |
| Chemical Exploration of a Highly Selective Scaffold with Activity against Intracellular Mycobacterium tuberculosis. | Njikan S, Ahmed S, Manning A, Awasthi D, Ovechkina Y, Chowdhury S, Butts A, Parish T. | Microbiol Spectr | 10.1128/spectrum.01161-22 | 2022 | | |
| Pathogenicity | Structural homology between 11 beta-hydroxysteroid dehydrogenase and Mycobacterium tuberculosis Inh-A enzyme: Dehydroepiandrosterone as a potential co-adjuvant treatment in diabetes-tuberculosis comorbidity. | Hernandez-Bustamante I, Santander-Plantamura Y, Mata-Espinosa D, Reyes-Chaparro A, Bini EI, Torre-Villalvazo I, Tovar AR, Barrios-Payan J, Marquina-Castillo B, Hernandez-Pando R, Carranza A. | Front Endocrinol (Lausanne) | 10.3389/fendo.2022.1055430 | 2022 | |
| Recombinant mycobacterial DNA-binding protein 1 with post-translational modifications boosts IFN-gamma production from BCG-vaccinated individuals' blood cells in combination with CpG-DNA. | Ozeki Y, Yokoyama A, Nishiyama A, Yoshida Y, Ohara Y, Mashima T, Tomiyama C, Shaban AK, Takeishi A, Osada-Oka M, Yamaguchi T, Tateishi Y, Maeyama JI, Hakamata M, Moro H, Kikuchi T, Hayashi D, Suzuki F, Yamamoto T, Iho S, Katahira M, Yamamoto S, Matsumoto S. | Sci Rep | 10.1038/s41598-024-58836-8 | 2024 | | |
| Investigation of Clofazimine Resistance and Genetic Mutations in Drug-Resistant Mycobacterium tuberculosis Isolates. | Park S, Jung J, Kim J, Han SB, Ryoo S. | J Clin Med | 10.3390/jcm11071927 | 2022 | | |
| Hit Compounds and Associated Targets in Intracellular Mycobacterium tuberculosis. | Tsui CKM, Sorrentino F, Narula G, Mendoza-Losana A, Del Rio RG, Herran EP, Lopez A, Bojang A, Zheng X, Remuinan-Blanco MJ, Av-Gay Y. | Molecules | 10.3390/molecules27144446 | 2022 | | |
| Description, validation, and review of a decade of experience with a laboratory-developed PCR test for detection of Mycobacterium tuberculosis complex in pulmonary and extrapulmonary specimens. | Buckwalter SP, Connelly BJ, Louison LK, Kolesch JM, Herring SA, Woodliff ED, Bolster LaSalle CM, Grys TE, Deml SM, Wohlfiel SL, Steinmetz LK, Wengenack NL. | J Clin Tuberc Other Mycobact Dis | 10.1016/j.jctube.2022.100340 | 2022 | | |
| A Peptidomic Approach to Identify Novel Antigen Biomarkers for the Diagnosis of Tuberculosis. | Chen H, Li S, Zhao W, Deng J, Yan Z, Zhang T, Wen SA, Guo H, Li L, Yuan J, Zhang H, Ma L, Zheng J, Gao M, Pang Y. | Infect Drug Resist | 10.2147/idr.s373652 | 2022 | | |
| Pathogenicity | Phenoxyalkylimidazoles with an oxadiazole moiety are subject to efflux in Mycobacterium tuberculosis. | Thayer MB, Parish T. | PLoS One | 10.1371/journal.pone.0239353 | 2021 | |
| Functional Genomics Identified Novel Genes Involved in Growth at Low Temperatures in Listeria monocytogenes. | Wu Y, Pang X, Liu X, Wu Y, Zhang X. | Microbiol Spectr | 10.1128/spectrum.00710-22 | 2022 | | |
| The challenges and opportunities of developing small molecule inhibitors of MraY. | Manning D, Huang TY, Berida T, Roy S. | Annu Rep Med Chem | 10.1016/bs.armc.2023.09.005 | 2023 | | |
| Genetics | Detection of Pyrazinamide Heteroresistance in Mycobacterium tuberculosis. | Werngren J, Mansjo M, Glader M, Hoffner S, Davies Forsman L. | Antimicrob Agents Chemother | 10.1128/aac.00720-21 | 2021 | |
| Pathogenicity | Therapeutic Potential of the Mycobacterium tuberculosis Mycolic Acid Transporter, MmpL3. | Li W, Obregon-Henao A, Wallach JB, North EJ, Lee RE, Gonzalez-Juarrero M, Schnappinger D, Jackson M. | Antimicrob Agents Chemother | 10.1128/aac.00826-16 | 2016 | |
| Homology modeling and molecular docking simulation of some novel imidazo[1,2-a]pyridine-3-carboxamide (IPA) series as inhibitors of Mycobacterium tuberculosis. | Abdullahi M, Adeniji SE, Arthur DE, Haruna A. | J Genet Eng Biotechnol | 10.1186/s43141-020-00102-1 | 2021 | | |
| Polytrimethylenimines: Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight. | Pachla J, Kopiasz RJ, Marek G, Tomaszewski W, Glogowska A, Drezek K, Kowalczyk S, Podgorski R, Butruk-Raszeja B, Ciach T, Mierzejewska J, Plichta A, Augustynowicz-Kopec E, Janczewski D. | Biomacromolecules | 10.1021/acs.biomac.3c00139 | 2023 | | |
| Deletion of Rv2571c confers resistance to arylamide compounds in Mycobacterium tuberculosis. | Shelton CD, McNeil MB, Early JV, Ioerger TR, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.02334-20 | 2023 | | |
| Role of the kdpDE Regulatory Operon of Mycobacterium tuberculosis in Modulating Bacterial Growth in vitro. | Cholo MC, Matjokotja MT, Osman AG, Anderson R. | Front Genet | 10.3389/fgene.2021.698875 | 2021 | | |
| Frequent Suboptimal Thermocycler Ramp Rate Usage Negatively Impacts GenoType MTBDRsl VER 2.0 Performance for Second-Line Drug-Resistant Tuberculosis Diagnosis. | Derendinger B, de Vos M, Pillay S, Venter R, Metcalfe J, Ghebrekristos Y, Minnies S, Dolby T, Beylis N, Warren R, Theron G. | J Mol Diagn | 10.1016/j.jmoldx.2022.01.003 | 2022 | | |
| Pathogenicity | Multiple Mutations in Mycobacterium tuberculosis MmpL3 Increase Resistance to MmpL3 Inhibitors. | McNeil MB, O'Malley T, Dennison D, Shelton CD, Sunde B, Parish T. | mSphere | 10.1128/msphere.00985-20 | 2020 | |
| Enhancement of mycobacterial pathogenesis by host interferon-gamma. | Hop HT, Liao PC, Wu HY. | Cell Mol Life Sci | 10.1007/s00018-024-05425-7 | 2024 | | |
| Absolute quantification of Mycoplasma pneumoniae in infected patients by droplet digital PCR to track disease severity and treatment efficacy. | Zhao H, Yan C, Feng Y, Du B, Feng J, Cui X, Cui J, Gan L, Fan Z, Xu Z, Fu T, Yu Z, Yuan J, Xue G. | Front Microbiol | 10.3389/fmicb.2023.1177273 | 2023 | | |
| Genetics | A Persistent Tuberculosis Outbreak in the UK Is Characterized by Hydrophobic fadB4-Deficient Mycobacterium tuberculosis That Replicates Rapidly in Macrophages. | Farzand R, Haigh RD, Monk P, Haldar P, Patel H, Pareek M, Verma R, Barer MR, Woltmann G, Ahyow L, Jagatia H, Decker J, Mukamolova GV, Cooper AM, Garton NJ, O'Hare HM. | mBio | 10.1128/mbio.02656-22 | 2022 | |
| Enzymology | Assessment of carbapenems in a mouse model of Mycobacterium tuberculosis infection. | Jadhav R, Gallardo-Macias R, Kumar G, Daher SS, Kaushik A, Bigelow KM, Nuermberger EL, Lamichhane G, Freundlich JS. | PLoS One | 10.1371/journal.pone.0249841 | 2021 | |
| Shotgun proteomic profiling of dormant, 'non-culturable' Mycobacterium tuberculosis. | Nikitushkin V, Shleeva M, Loginov D, Dycka F F, Sterba J, Kaprelyants A. | PLoS One | 10.1371/journal.pone.0269847 | 2022 | | |
| Metabolism | Phosphoproteomic Approaches to Discover Novel Substrates of Mycobacterial Ser/Thr Protein Kinases. | Baros SS, Blackburn JM, Soares NC. | Mol Cell Proteomics | 10.1074/mcp.r119.001668 | 2020 | |
| Metabolism | Host- and Age-Dependent Transcriptional Changes in Mycobacterium tuberculosis Cell Envelope Biosynthesis Genes after Exposure to Human Alveolar Lining Fluid. | Allue-Guardia A, Garcia-Vilanova A, Olmo-Fontanez AM, Peters J, Maselli DJ, Wang Y, Turner J, Schlesinger LS, Torrelles JB. | Int J Mol Sci | 10.3390/ijms23020983 | 2022 | |
| Pathogenicity | Deletion of N-acetylmuramyl-L-alanine amidases alters the host immune response to Mycobacterium tuberculosis infection. | Kieswetter NS, Ozturk M, Jones SS, Senzani S, Chengalroyen MD, Brombacher F, Kana B, Guler R. | Virulence | 10.1080/21505594.2021.1914448 | 2021 | |
| Identification of nontuberculous mycobacteria species by multiplex real-time PCR with high-resolution melting. | Peixoto ADS, Montenegro LML, Lima AS, Melo FL, Barbosa Junior WL, Neves MMC, Ramos JP, Schindler HC, Medeiros ZM. | Rev Soc Bras Med Trop | 10.1590/0037-8682-0211-2020 | 2020 | | |
| Pathogenicity | A high-throughput whole cell screen to identify inhibitors of Mycobacterium tuberculosis. | Ollinger J, Kumar A, Roberts DM, Bailey MA, Casey A, Parish T. | PLoS One | 10.1371/journal.pone.0205479 | 2019 | |
| Genetics | Beyond blast: enabling microbiologists to better extract literature, taxonomic distributions and gene neighbourhood information for protein families. | Reed CJ, Denise R, Hourihan J, Babor J, Jaroch M, Martinelli M, Hutinet G, de Crecy-Lagard V. | Microb Genom | 10.1099/mgen.0.001183 | 2024 | |
| Pathogenicity | A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro. | Patel N, O'Malley T, Zhang YK, Xia Y, Sunde B, Flint L, Korkegian A, Ioerger TR, Sacchettini J, Alley MRK, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.01205-17 | 2017 | |
| Pathogenicity | Consensus-Guided Construction of H5N1-Specific and Universal Influenza a Multiepitope Vaccines. | Palma M. | Biology (Basel) | 10.3390/biology14101327 | 2025 | |
| SILVI, an open-source pipeline for T-cell epitope selection. | Pissarra J, Dorkeld F, Loire E, Bonhomme V, Sereno D, Lemesre JL, Holzmuller P. | PLoS One | 10.1371/journal.pone.0273494 | 2022 | | |
| Pathogenicity | Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis. | Singh SB, Odingo J, Bailey MA, Sunde B, Korkegian A, O'Malley T, Ovechkina Y, Ioerger TR, Sacchettini JC, Young K, Olsen DB, Parish T. | BMC Res Notes | 10.1186/s13104-018-3526-z | 2018 | |
| Mycobactin analogue interacting with siderophore efflux-pump protein: insights from molecular dynamics simulations and whole-cell assays. | Shyam M, Thakur A, Velez C, Daniel C, Acevedo O, Bhakta S, Jayaprakash V. | Front Antibiot | 10.3389/frabi.2024.1362516 | 2024 | | |
| The efficacy of commercial decontamination agents differs between standardised test settings and research laboratory usage for a variety of bacterial species. | Uy B, Read H, van de Pas S, Marnane R, Casu F, Swift S, Wiles S. | PeerJ | 10.7717/peerj.13646 | 2022 | | |
| Pathogenicity | Effects of Cigarette Smoke Condensate on Growth and Biofilm Formation by Mycobacterium tuberculosis. | Cholo MC, Rasehlo SSM, Venter E, Venter C, Anderson R. | Biomed Res Int | 10.1155/2020/8237402 | 2020 | |
| Pathogenicity | Novel MenA Inhibitors Are Bactericidal against Mycobacterium tuberculosis and Synergize with Electron Transport Chain Inhibitors. | Berube BJ, Russell D, Castro L, Choi SR, Narayanasamy P, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.02661-18 | 2019 | |
| Imidazoles Induce Reactive Oxygen Species in Mycobacterium tuberculosis Which Is Not Associated with Cell Death. | Howell Wescott HA, Roberts DM, Allebach CL, Kokoczka R, Parish T. | ACS Omega | 10.1021/acsomega.6b00212 | 2017 | | |
| CD84 is a Suppressor of T and B Cell Activation during Mycobacterium tuberculosis Pathogenesis. | Zheng N, Fleming J, Hu P, Jiao J, Zhang G, Yang R, Li C, Liu Y, Bi L, Zhang H. | Microbiol Spectr | 10.1128/spectrum.01557-21 | 2022 | | |
| Enzymology | Crystal Structure of Phosphoserine BlaC from Mycobacterium tuberculosis Inactivated by Bis(Benzoyl) Phosphate. | Moural TW, White DS, Choy CJ, Kang C, Berkman CE. | Int J Mol Sci | 10.3390/ijms20133247 | 2019 | |
| Identification of Enolase as the Target of 2-Aminothiazoles in Mycobacterium tuberculosis. | Wescott HH, Zuniga ES, Bajpai A, Trujillo C, Ehrt S, Schnappinger D, Roberts DM, Parish T. | Front Microbiol | 10.3389/fmicb.2018.02542 | 2018 | | |
| Pathogenicity | In Vitro Isolation and Characterization of Oxazolidinone-Resistant Mycobacterium tuberculosis. | McNeil MB, Dennison DD, Shelton CD, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.01296-17 | 2017 | |
| Pathogenicity | The 7-phenyl benzoxaborole series is active against Mycobacterium tuberculosis. | Korkegian A, O'Malley T, Xia Y, Zhou Y, Carter DS, Sunde B, Flint L, Thompson D, Ioerger TR, Sacchettini J, Alley MRK, Parish T. | Tuberculosis (Edinb) | 10.1016/j.tube.2017.11.003 | 2018 | |
| 3-(5-Nitrofuran-2-yl)prop-2-en-1-one Derivatives, with Potent Antituberculosis Activity, Inhibit A Novel Therapeutic Target, Arylamine N-acetyltransferase, in Mycobacteria. | Agre N, Tawari N, Maitra A, Gupta A, Munshi T, Degani M, Bhakta S. | Antibiotics (Basel) | 10.3390/antibiotics9070368 | 2020 | | |
| Rapid, direct detection of bacterial topoisomerase 1-DNA adducts by RADAR/ELISA. | Sinha D, Kiianitsa K, Sherman DR, Maizels N. | Anal Biochem | 10.1016/j.ab.2020.113827 | 2020 | | |
| Bacterial catabolism of acetovanillone, a lignin-derived compound. | Dexter GN, Navas LE, Grigg JC, Bajwa H, Levy-Booth DJ, Liu J, Louie NA, Nasseri SA, Jang SK, Renneckar S, Eltis LD, Mohn WW. | Proc Natl Acad Sci U S A | 10.1073/pnas.2213450119 | 2022 | | |
| Mycobacterium tuberculosis Affects Protein and Lipid Content of Circulating Exosomes in Infected Patients Depending on Tuberculosis Disease State. | Biadglegne F, Schmidt JR, Engel KM, Lehmann J, Lehmann RT, Reinert A, Konig B, Schiller J, Kalkhof S, Sack U. | Biomedicines | 10.3390/biomedicines10040783 | 2022 | | |
| Identification of Novel Chemical Scaffolds that Inhibit the Growth of Mycobacterium tuberculosis in Macrophages. | Ahmed S, Manning A, Flint L, Awasthi D, Ovechkina Y, Parish T. | Front Pharmacol | 10.3389/fphar.2021.790583 | 2021 | | |
| 50S subunit recognition and modification by the Mycobacterium tuberculosis ribosomal RNA methyltransferase TlyA. | Laughlin ZT, Nandi S, Dey D, Zelinskaya N, Witek MA, Srinivas P, Nguyen HA, Kuiper EG, Comstock LR, Dunham CM, Conn GL. | Proc Natl Acad Sci U S A | 10.1073/pnas.2120352119 | 2022 | | |
| Pathogenicity | EPR interpretation, magnetism and biological study of a Cu(II) dinuclear complex assisted by a schiff base precursor. | Das K, Patra C, Sen C, Datta A, Massera C, Garribba E, El Fallah MS, Beyene BB, Hung CH, Sinha C, Askun T, Celikboyun P, Escudero D, Frontera A. | J Biol Inorg Chem | 10.1007/s00775-016-1428-x | 2017 | |
| Pathogenicity | In vitro activity of AZD5847 against geographically diverse clinical isolates of Mycobacterium tuberculosis. | Werngren J, Wijkander M, Perskvist N, Balasubramanian V, Sambandamurthy VK, Rodrigues C, Hoffner S. | Antimicrob Agents Chemother | 10.1128/aac.02718-14 | 2014 | |
| Micro-nanoemulsion and nanoparticle-assisted drug delivery against drug-resistant tuberculosis: recent developments. | Suman SK, Chandrasekaran N, Priya Doss CG. | Clin Microbiol Rev | 10.1128/cmr.00088-23 | 2023 | | |
| In Silico Drug Repurposing Studies for the Discovery of Novel Salicyl-AMP Ligase (MbtA)Inhibitors. | Rakshit G, Biswas A, Jayaprakash V. | Pathogens | 10.3390/pathogens12121433 | 2023 | | |
| Proteome | Antigen 85B peptidomic analysis allows species-specific mycobacterial identification. | Zhang W, Shu Q, Zhao Z, Fan J, Lyon CJ, Zelazny AM, Hu Y. | Clin Proteomics | 10.1186/s12014-017-9177-6 | 2018 | |
| Pathogenicity | Combinations of Respiratory Chain Inhibitors Have Enhanced Bactericidal Activity against Mycobacterium tuberculosis. | Berube BJ, Parish T. | Antimicrob Agents Chemother | 10.1128/aac.01677-17 | 2018 | |
| Metabolism | Synergistic Interactions of MmpL3 Inhibitors with Antitubercular Compounds In Vitro. | Li W, Sanchez-Hidalgo A, Jones V, de Moura VC, North EJ, Jackson M. | Antimicrob Agents Chemother | 10.1128/aac.02399-16 | 2017 | |
| GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment. | Nuermberger EL, Martinez-Martinez MS, Sanz O, Urones B, Esquivias J, Soni H, Tasneen R, Tyagi S, Li SY, Converse PJ, Boshoff HI, Robertson GT, Besra GS, Abrahams KA, Upton AM, Mdluli K, Boyle GW, Turner S, Fotouhi N, Cammack NC, Siles JM, Alonso M, Escribano J, Lelievre J, Rullas-Trincado J, Perez-Herran E, Bates RH, Maher-Edwards G, Barros D, Ballell L, Jimenez E. | Antimicrob Agents Chemother | 10.1128/aac.00132-22 | 2022 | | |
| Identification of potential non-nucleoside MraY inhibitors for tuberculosis chemotherapy using structure-based virtual screening. | Pandey P, Chatterjee S, Berida T, Doerksen RJ, Roy S. | J Biomol Struct Dyn | 10.1080/07391102.2020.1862705 | 2022 | | |
| Marine sponge derived natural products as inhibitors of mycothiol-S-conjugate amidase. | Saxena A, Mishra S. | Bioinformation | 10.6026/97320630013256 | 2017 | | |
| Main-chain flexibility and hydrophobicity of ionenes strongly impact their antimicrobial activity: an extended study on drug resistance strains and Mycobacterium. | Kopiasz RJ, Zabost A, Myszka M, Kuzminska A, Drezek K, Mierzejewska J, Tomaszewski W, Iwanska A, Augustynowicz-Kopec E, Ciach T, Janczewski D. | RSC Adv | 10.1039/d2ra04121a | 2022 | | |
| Enzymology | [A new method for the disruption of cell walls of gram-positive bacteria and mycobacteria on the point of nucleic acid extraction: sand method]. | Sahin F, Kiyan M, Karasartova D, Calgin MK, Akhter S, Turegun Atasoy B. | Mikrobiyol Bul | 10.5578/mb.10685 | 2016 | |
| Novel In Silico mRNA vaccine design exploiting proteins of M. tuberculosis that modulates host immune responses by inducing epigenetic modifications. | Al Tbeishat H. | Sci Rep | 10.1038/s41598-022-08506-4 | 2022 | | |
| Pathogenicity | In vitro antimicrobial and antimycobacterial activity and HPLC-DAD screening of phenolics from Chenopodium ambrosioides L. | Jesus RS, Piana M, Freitas RB, Brum TF, Alves CFS, Belke BV, Mossmann NJ, Cruz RC, Santos RCV, Dalmolin TV, Bianchini BV, Campos MMA, Bauermann LF. | Braz J Microbiol | 10.1016/j.bjm.2017.02.012 | 2018 | |
| Possible Cross-Reactivity between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death. | Root-Bernstein R. | Vaccines (Basel) | 10.3390/vaccines8040559 | 2020 | | |
| Interaction of Mycobacteria With Host Cell Inflammasomes. | Rastogi S, Briken V. | Front Immunol | 10.3389/fimmu.2022.791136 | 2022 | | |
| 4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure-activity relationship studies. | Yusufzai SK, Osman H, Khan MS, Abd Razik BM, Ezzat MO, Mohamad S, Sulaiman O, Gansau JA, Parumasivam T. | Chem Cent J | 10.1186/s13065-018-0435-0 | 2018 | | |
| Visualization and Quantification of Phagocytosis by Neutrophils. | Guzman G, Tafesse FG. | Methods Mol Biol | 10.1007/978-1-0716-0154-9_11 | 2020 | | |
| Anti-mycobacterium tuberculosis activity of polyherbal medicines used for the treatment of tuberculosis in Eastern Cape, South Africa. | Famewo EB, Clarke AM, Wiid I, Ngwane A, van Helden P, Afolayan AJ. | Afr Health Sci | 10.4314/ahs.v17i3.21 | 2017 | | |
| Design, synthesis and anti-mycobacterial evaluation of imidazo[1,2-a]pyridine analogues. | Khetmalis YM, Chitti S, Umarani Wunnava A, Karan Kumar B, Murali Krishna Kumar M, Murugesan S, Chandra Sekhar KVG. | RSC Med Chem | 10.1039/d1md00367d | 2022 | | |
| Bacterial cytochrome P450s: a bioinformatics odyssey of substrate discovery. | Schottlender G, Prieto JM, Clemente C, Schuster CD, Dumas V, Fernandez Do Porto D, Marti MA. | Front Microbiol | 10.3389/fmicb.2024.1343029 | 2024 | | |
| Filamentation modulates allosteric regulation of PRPS. | Hu HH, Lu GM, Chang CC, Li Y, Zhong J, Guo CJ, Zhou X, Yin B, Zhang T, Liu JL. | Elife | 10.7554/elife.79552 | 2022 | | |
| Identification of beta-Lactams Active against Mycobacterium tuberculosis by a Consortium of Pharmaceutical Companies and Academic Institutions. | Gold B, Zhang J, Quezada LL, Roberts J, Ling Y, Wood M, Shinwari W, Goullieux L, Roubert C, Fraisse L, Bacque E, Lagrange S, Filoche-Romme B, Vieth M, Hipskind PA, Jungheim LN, Aube J, Scarry SM, McDonald SL, Li K, Perkowski A, Nguyen Q, Dartois V, Zimmerman M, Olsen DB, Young K, Bonnett S, Joerss D, Parish T, Boshoff HI, Arora K, Barry CE, Guijarro L, Anca S, Rullas J, Rodriguez-Salguero B, Martinez-Martinez MS, Porras-De Francisco E, Cacho M, Barros-Aguirre D, Smith P, Berthel SJ, Nathan C, Bates RH. | ACS Infect Dis | 10.1021/acsinfecdis.1c00570 | 2022 | | |
| Metabolism | Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features. | Aiewsakun P, Prombutara P, Siregar TAP, Laopanupong T, Kanjanasirirat P, Khumpanied T, Borwornpinyo S, Tong-Ngam P, Tubsuwan A, Srilohasin P, Chaiprasert A, Ruangchai W, Palittapongarnpim P, Prammananan T, VanderVen BC, Ponpuak M. | Sci Rep | 10.1038/s41598-021-82905-x | 2021 | |
| Enzymology | Synthesis and In Vitro Biological Evaluation of Quinolinyl Pyrimidines Targeting Type II NADH-Dehydrogenase (NDH-2). | Lu L, Akerbladh L, Ahmad S, Konda V, Cao S, Vocat A, Maes L, Cole ST, Hughes D, Larhed M, Brandt P, Karlen A, Mowbray SL. | ACS Infect Dis | 10.1021/acsinfecdis.1c00413 | 2022 | |
| The Genetic Determinants of Extreme UV Radiation and Desiccation Tolerance in a Bacterium Recovered from the Stratosphere. | Ellington AJ, Schult TJ, Reisch CR, Christner BC. | Microorganisms | 10.3390/microorganisms13040756 | 2025 | | |
| SAR study of piperidine derivatives as inhibitors of 1,4-dihydroxy-2-naphthoate isoprenyltransferase (MenA) from Mycobacterium tuberculosis. | Berg K, Hegde P, Pujari V, Brinkmann M, Wilkins DZ, Parish T, Crick DC, Aldrich CC. | Eur J Med Chem | 10.1016/j.ejmech.2023.115125 | 2023 | | |
| Pathogenicity | Detection of heteroresistant Mycobacterium tuberculosis by pyrosequencing. | Engstrom A, Hoffner S, Jureen P. | J Clin Microbiol | 10.1128/jcm.01761-13 | 2013 | |
| Carprofen elicits pleiotropic mechanisms of bactericidal action with the potential to reverse antimicrobial drug resistance in tuberculosis. | Maitra A, Evangelopoulos D, Chrzastek A, Martin LT, Hanrath A, Chapman E, Hailes HC, Lipman M, McHugh TD, Waddell SJ, Bhakta S. | J Antimicrob Chemother | 10.1093/jac/dkaa307 | 2020 | | |
| Metabolism | Secreted Rv1768 From RD14 of Mycobacterium tuberculosis Activates Macrophages and Induces a Strong IFN-gamma-Releasing of CD4+ T Cells. | Yuan CH, Zhang S, Xiang F, Gong H, Wang Q, Chen Y, Luo W. | Front Cell Infect Microbiol | 10.3389/fcimb.2019.00341 | 2019 | |
| Rv3091, An Extracellular Patatin-Like Phospholipase in Mycobacterium tuberculosis, Prolongs Intracellular Survival of Recombinant Mycolicibacterium smegmatis by Mediating Phagosomal Escape. | Cui Z, Dang G, Song N, Cui Y, Li Z, Zang X, Liu H, Wang Z, Liu S. | Front Microbiol | 10.3389/fmicb.2020.532371 | 2020 | | |
| Pathogenicity | Evaluation of agar-based medium with sheep sera for testing of drug susceptibility of Mycobacterium tuberculosis to Isoniazid, Rifampin, Ethambutol, and Streptomycin. | Coban AY, Uzun M, Bozdogan B. | J Clin Microbiol | 10.1128/jcm.01947-13 | 2013 | |
| Insight into novel clinical mutants of RpsA-S324F, E325K, and G341R of Mycobacterium tuberculosis associated with pyrazinamide resistance. | Khan MT, Rehaman AU, Junaid M, Malik SI, Wei DQ. | Comput Struct Biotechnol J | 10.1016/j.csbj.2018.09.004 | 2018 | | |
| Crystal structure of Rv1220c, a SAM-dependent O-methyltransferase from Mycobacterium tuberculosis. | Yan Q, Shaw N, Qian L, Jiang D. | Acta Crystallogr F Struct Biol Commun | 10.1107/s2053230x17006057 | 2017 | | |
| Enzymology | Point-of-care system for detection of Mycobacterium tuberculosis and rifampin resistance in sputum samples. | Castan P, de Pablo A, Fernandez-Romero N, Rubio JM, Cobb BD, Mingorance J, Toro C. | J Clin Microbiol | 10.1128/jcm.02209-13 | 2014 | |
| Mycobacterium tuberculosis Rv0560c is not essential for growth in vitro or in macrophages. | Kokoczka R, Schuessler DL, Early JV, Parish T. | Tuberculosis (Edinb) | 10.1016/j.tube.2016.11.001 | 2017 | | |
| Macrophage Exposure to Polycyclic Aromatic Hydrocarbons From Wood Smoke Reduces the Ability to Control Growth of Mycobacterium tuberculosis. | Sada-Ovalle I, Chavez-Galan L, Vasquez L, Aldriguetti S, Rosas-Perez I, Ramirez-Venegas A, Perez-Padilla R, Torre-Bouscoulet L. | Front Med (Lausanne) | 10.3389/fmed.2018.00309 | 2018 | | |
| Metabolism | Integrative proteomic and glycoproteomic profiling of Mycobacterium tuberculosis culture filtrate. | Tucci P, Portela M, Chetto CR, Gonzalez-Sapienza G, Marin M. | PLoS One | 10.1371/journal.pone.0221837 | 2020 | |
| Metabolism | Toxin-mediated ribosome stalling reprograms the Mycobacterium tuberculosis proteome. | Barth VC, Zeng JM, Vvedenskaya IO, Ouyang M, Husson RN, Woychik NA. | Nat Commun | 10.1038/s41467-019-10869-8 | 2019 | |
| The 1, 2-ethylenediamine SQ109 protects against tuberculosis by promoting M1 macrophage polarization through the p38 MAPK pathway. | Singh M, Kumar S, Singh B, Jain P, Kumari A, Pahuja I, Chaturvedi S, Prasad DVR, Dwivedi VP, Das G. | Commun Biol | 10.1038/s42003-022-03693-2 | 2022 | | |
| Self-adjuvanting nanovaccines boost lung-resident CD4+ T cell immune responses in BCG-primed mice. | Files MA, Naqvi KF, Saito TB, Clover TM, Rudra JS, Endsley JJ. | NPJ Vaccines | 10.1038/s41541-022-00466-0 | 2022 | | |
| Protein and Microbial Biomarkers in Sputum Discern Acute and Latent Tuberculosis in Investigation of Pastoral Ethiopian Cohort. | HaileMariam M, Yu Y, Singh H, Teklu T, Wondale B, Worku A, Zewude A, Mounaud S, Tsitrin T, Legesse M, Gobena A, Pieper R. | Front Cell Infect Microbiol | 10.3389/fcimb.2021.595554 | 2021 | | |
| Boldine-Derived Alkaloids Inhibit the Activity of DNA Topoisomerase I and Growth of Mycobacterium tuberculosis. | Garcia MT, Carreno D, Tirado-Velez JM, Ferrandiz MJ, Rodrigues L, Gracia B, Amblar M, Ainsa JA, de la Campa AG. | Front Microbiol | 10.3389/fmicb.2018.01659 | 2018 | | |
| Pathogenicity | Non-pncA Gene-Mutated but Pyrazinamide-Resistant Mycobacterium tuberculosis: Why Is That? | Werngren J, Alm E, Mansjo M. | J Clin Microbiol | 10.1128/jcm.02532-16 | 2017 | |
| Metabolism | Small RNA Mcr11 requires the transcription factor AbmR for stable expression and regulates genes involved in the central metabolism of Mycobacterium tuberculosis. | Girardin RC, McDonough KA. | Mol Microbiol | 10.1111/mmi.14436 | 2020 | |
| Mycobacterium tuberculosis Inhibits Autocrine Type I IFN Signaling to Increase Intracellular Survival. | Banks DA, Ahlbrand SE, Hughitt VK, Shah S, Mayer-Barber KD, Vogel SN, El-Sayed NM, Briken V. | J Immunol | 10.4049/jimmunol.1801303 | 2019 | | |
| Phylogeny | Variation among genome sequences of H37Rv strains of Mycobacterium tuberculosis from multiple laboratories. | Ioerger TR, Feng Y, Ganesula K, Chen X, Dobos KM, Fortune S, Jacobs WR, Mizrahi V, Parish T, Rubin E, Sassetti C, Sacchettini JC. | J Bacteriol | 10.1128/jb.00166-10 | 2010 | |
| Differences in plasma proteomes for active tuberculosis, latent tuberculosis and non-tuberculosis mycobacterial lung disease patients with and without ESAT-6/CFP10 stimulation. | Teklu T, Wondale B, Taye B, Hailemariam M, Bekele S, Tamirat M, Zewude A, Mohamed T, Medhin G, Legesse M, Yu Y, Ameni G, Pieper R. | Proteome Sci | 10.1186/s12953-020-00165-5 | 2020 | | |
| N-Acylated Ciprofloxacin Derivatives: Synthesis and In Vitro Biological Evaluation as Antibacterial and Anticancer Agents. | Struga M, Roszkowski P, Bielenica A, Otto-Slusarczyk D, Stepien K, Stefanska J, Zabost A, Augustynowicz-Kopec E, Kolinski M, Kmiecik S, Myslovska A, Wrzosek M. | ACS Omega | 10.1021/acsomega.3c00554 | 2023 | | |
| Pathogenicity | Rapid detection of multidrug-resistant Mycobacterium tuberculosis using the malachite green decolourisation assay. | Coban AY, Uzun M. | Mem Inst Oswaldo Cruz | 10.1590/0074-0276130697 | 2013 | |
| Pathogenicity | Antituberculosis activity, phytochemical identification of Costus speciosus (J. Koenig) Sm., Cymbopogon citratus (DC. Ex Nees) Stapf., and Tabernaemontana coronaria (L.) Willd. and their effects on the growth kinetics and cellular integrity of Mycobacterium tuberculosis H37Rv. | Mohamad S, Ismail NN, Parumasivam T, Ibrahim P, Osman H, A Wahab H. | BMC Complement Altern Med | 10.1186/s12906-017-2077-5 | 2018 | |
| Pathogenicity | Reevaluation of the critical concentration for drug susceptibility testing of Mycobacterium tuberculosis against pyrazinamide using wild-type MIC distributions and pncA gene sequencing. | Werngren J, Sturegard E, Jureen P, Angeby K, Hoffner S, Schon T. | Antimicrob Agents Chemother | 10.1128/aac.05894-11 | 2012 | |
| Metabolism | The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner. | Schneefeld M, Busche T, Geffers R, Kalinowski J, Bange FC. | PLoS One | 10.1371/journal.pone.0186505 | 2017 | |
| Pathogenicity | Novel insights into the mechanism of inhibition of MmpL3, a target of multiple pharmacophores in Mycobacterium tuberculosis. | Li W, Upadhyay A, Fontes FL, North EJ, Wang Y, Crans DC, Grzegorzewicz AE, Jones V, Franzblau SG, Lee RE, Crick DC, Jackson M. | Antimicrob Agents Chemother | 10.1128/aac.03229-14 | 2014 | |
| Metabolism | NAD hydrolysis by the tuberculosis necrotizing toxin induces lethal oxidative stress in macrophages. | Pajuelo D, Gonzalez-Juarbe N, Niederweis M. | Cell Microbiol | 10.1111/cmi.13115 | 2020 | |
| Activity-Based Protein Profiling Reveals That Cephalosporins Selectively Active on Non-replicating Mycobacterium tuberculosis Bind Multiple Protein Families and Spare Peptidoglycan Transpeptidases. | Lopez Quezada L, Smith R, Lupoli TJ, Edoo Z, Li X, Gold B, Roberts J, Ling Y, Park SW, Nguyen Q, Schoenen FJ, Li K, Hugonnet JE, Arthur M, Sacchettini JC, Nathan C, Aube J. | Front Microbiol | 10.3389/fmicb.2020.01248 | 2020 | | |
| Metabolism | Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners. | Ortega Ugalde S, de Koning CP, Wallraven K, Bruyneel B, Vermeulen NPE, Grossmann TN, Bitter W, Commandeur JNM, Vos JC. | Appl Microbiol Biotechnol | 10.1007/s00253-018-9299-4 | 2018 | |
| Pathogenicity | Reduced susceptibility of clinical strains of Mycobacterium tuberculosis to reactive nitrogen species promotes survival in activated macrophages. | Idh J, Andersson B, Lerm M, Raffetseder J, Eklund D, Woksepp H, Werngren J, Mansjo M, Sundqvist T, Stendahl O, Schon T. | PLoS One | 10.1371/journal.pone.0181221 | 2017 | |
| Metabolism | Rapid and specific labeling of single live Mycobacterium tuberculosis with a dual-targeting fluorogenic probe. | Cheng Y, Xie J, Lee KH, Gaur RL, Song A, Dai T, Ren H, Wu J, Sun Z, Banaei N, Akin D, Rao J. | Sci Transl Med | 10.1126/scitranslmed.aar4470 | 2018 | |
| Metabolism | CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis. | Dodd CE, Pyle CJ, Glowinski R, Rajaram MV, Schlesinger LS. | J Immunol | 10.4049/jimmunol.1600856 | 2016 | |
| Metabolism | Loss-of-Function Mutations in HspR Rescue the Growth Defect of a Mycobacterium tuberculosis Proteasome Accessory Factor E (pafE) Mutant. | Jastrab JB, Samanovic MI, Copin R, Shopsin B, Darwin KH. | J Bacteriol | 10.1128/jb.00850-16 | 2017 | |
| Metabolism | Peptidyl-prolyl isomerase-B is involved in Mycobacterium tuberculosis biofilm formation and a generic target for drug repurposing-based intervention. | Kumar A, Alam A, Grover S, Pandey S, Tripathi D, Kumari M, Rani M, Singh A, Akhter Y, Ehtesham NZ, Hasnain SE. | NPJ Biofilms Microbiomes | 10.1038/s41522-018-0075-0 | 2019 | |
| Enzymology | Differential inhibition of adenylylated and deadenylylated forms of M. tuberculosis glutamine synthetase as a drug discovery platform. | Theron A, Roth RL, Hoppe H, Parkinson C, van der Westhuyzen CW, Stoychev S, Wiid I, Pietersen RD, Baker B, Kenyon CP. | PLoS One | 10.1371/journal.pone.0185068 | 2017 | |
| Metabolism | Deciphering the molecular basis of mycobacteria and lipoglycan recognition by the C-type lectin Dectin-2. | Decout A, Silva-Gomes S, Drocourt D, Blattes E, Riviere M, Prandi J, Larrouy-Maumus G, Caminade AM, Hamasur B, Kallenius G, Kaur D, Dobos KM, Lucas M, Sutcliffe IC, Besra GS, Appelmelk BJ, Gilleron M, Jackson M, Vercellone A, Tiraby G, Nigou J. | Sci Rep | 10.1038/s41598-018-35393-5 | 2018 | |
| Enzymology | Cloning of the Recombinant Cytochrome P450 Cyp141 Protein of Mycobacterium tuberculosis as a Diagnostic Target and Vaccine Candidate. | Rabiee-Faradonbeh M, Darban-Sarokhalil D, Feizabadi MM, Alvandi A, Momtaz H, Soleimani N, Gholipour A. | Iran Red Crescent Med J | 10.5812/ircmj.18001 | 2014 | |
| An Immunoinformatics Approach to Design a Potent Multi-Epitope Vaccine against Asia-1 Genotype of Crimean-Congo Haemorrhagic Fever Virus Using the Structural Glycoproteins as a Target. | Shah SZ, Jabbar B, Mirza MU, Waqas M, Aziz S, Halim SA, Ali A, Rafique S, Idrees M, Khalid A, Abdalla AN, Khan A, Al-Harrasi A. | Vaccines (Basel) | 10.3390/vaccines11010061 | 2022 | | |
| Metabolism | Deletion of PPARgamma in lung macrophages provides an immunoprotective response against M. tuberculosis infection in mice. | Guirado E, Rajaram MV, Chawla A, Daigle J, La Perle KM, Arnett E, Turner J, Schlesinger LS. | Tuberculosis (Edinb) | 10.1016/j.tube.2018.06.012 | 2018 | |
| Mycobacterium tuberculosis DosR is required for activity of the PmbtB and PmbtI promoters under hypoxia. | Schreuder LJ, Parish T. | PLoS One | 10.1371/journal.pone.0107283 | 2014 | | |
| Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA. | Xia Y, Zhou Y, Carter DS, McNeil MB, Choi W, Halladay J, Berry PW, Mao W, Hernandez V, O'Malley T, Korkegian A, Sunde B, Flint L, Woolhiser LK, Scherman MS, Gruppo V, Hastings C, Robertson GT, Ioerger TR, Sacchettini J, Tonge PJ, Lenaerts AJ, Parish T, Alley M. | Life Sci Alliance | 10.26508/lsa.201800025 | 2018 | | |
| Characterization of mycobacterium isolates from pulmomary tuberculosis suspected cases visiting Tuberculosis Reference Laboratory at Ethiopian Health and Nutrition Research Institute, Addis Ababa Ethiopia: a cross sectional study. | Mathewos B, Kebede N, Kassa T, Mihret A, Getahun M. | Asian Pac J Trop Med | 10.1016/s1995-7645(14)60184-x | 2015 | | |
| Enzymology | Evolutionary analysis of a novel zinc ribbon in the N-terminal region of threonine synthase. | Kaur G, Subramanian S. | Cell Cycle | 10.1080/15384101.2017.1363937 | 2017 | |
| Pathogenicity | The presence of a galactosamine substituent on the arabinogalactan of Mycobacterium tuberculosis abrogates full maturation of human peripheral blood monocyte-derived dendritic cells and increases secretion of IL-10. | Wheat WH, Dhouib R, Angala SK, Larrouy-Maumus G, Dobos K, Nigou J, Spencer JS, Jackson M. | Tuberculosis (Edinb) | 10.1016/j.tube.2015.04.002 | 2015 | |
| Metabolism | Biosynthesis of the Methylthioxylose Capping Motif of Lipoarabinomannan in Mycobacterium tuberculosis. | Angala SK, McNeil MR, Shi L, Joe M, Pham H, Zuberogoitia S, Nigou J, Boot CM, Lowary TL, Gilleron M, Jackson M. | ACS Chem Biol | 10.1021/acschembio.6b01071 | 2017 | |
| Synthesis and Tuberculostatic Activity Evaluation of Novel Benzazoles with Alkyl, Cycloalkyl or Pyridine Moiety. | Krause M, Foks H, Augustynowicz-Kopec E, Napiorkowska A, Szczesio M, Gobis K. | Molecules | 10.3390/molecules23040985 | 2018 | | |
| Pathogenicity | A new rapid colourimetric method for testing Mycobacterium tuberculosis susceptibility to isoniazid and rifampicin: a crystal violet decolourisation assay. | Coban AY. | Mem Inst Oswaldo Cruz | 10.1590/0074-0276140297 | 2014 | |
| Pathogenicity | Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA. | Lopez Quezada L, Silve S, Kelinske M, Liba A, Diaz Gonzalez C, Kotev M, Goullieux L, Sans S, Roubert C, Lagrange S, Bacque E, Couturier C, Pellet A, Blanc I, Ferron M, Debu F, Li K, Aube J, Roberts J, Little D, Ling Y, Zhang J, Gold B, Nathan C. | mBio | 10.1128/mbio.01405-19 | 2019 | |
| Pathogenicity | Dried culture spots for Xpert MTB/RIF external quality assessment: results of a phase 1 pilot study in South Africa. | Scott LE, Gous N, Cunningham BE, Kana BD, Perovic O, Erasmus L, Coetzee GJ, Koornhof H, Stevens W. | J Clin Microbiol | 10.1128/jcm.05167-11 | 2011 | |
| Structural and free energy landscape of novel mutations in ribosomal protein S1 (rpsA) associated with pyrazinamide resistance. | Khan MT, Khan A, Rehman AU, Wang Y, Akhtar K, Malik SI, Wei DQ. | Sci Rep | 10.1038/s41598-019-44013-9 | 2019 | | |
| Use of a rapid recombinase-aided amplification assay for Mycoplasma pneumoniae detection. | Xue G, Li S, Zhao H, Yan C, Feng Y, Cui J, Jiang T, Yuan J. | BMC Infect Dis | 10.1186/s12879-019-4750-4 | 2020 | | |
| Pathogenicity | Pyrosequencing for rapid detection of Mycobacterium tuberculosis resistance to rifampin, isoniazid, and fluoroquinolones. | Bravo LT, Tuohy MJ, Ang C, Destura RV, Mendoza M, Procop GW, Gordon SM, Hall GS, Shrestha NK. | J Clin Microbiol | 10.1128/jcm.01229-09 | 2009 | |
| Metabolism | AbmR (Rv1265) is a novel transcription factor of Mycobacterium tuberculosis that regulates host cell association and expression of the non-coding small RNA Mcr11. | Girardin RC, Bai G, He J, Sui H, McDonough KA. | Mol Microbiol | 10.1111/mmi.14126 | 2018 | |
| Pathogenicity | Cytokinin Signaling in Mycobacterium tuberculosis. | Samanovic MI, Hsu HC, Jones MB, Jones V, McNeil MR, Becker SH, Jordan AT, Strnad M, Xu C, Jackson M, Li H, Darwin KH. | mBio | 10.1128/mbio.00989-18 | 2018 | |
| Pathogenicity | Thiosemicarbazide Derivatives Decrease the ATPase Activity of Staphylococcus aureus Topoisomerase IV, Inhibit Mycobacterial Growth, and Affect Replication in Mycobacterium smegmatis. | Kowalczyk A, Paneth A, Trojanowski D, Paneth P, Zakrzewska-Czerwinska J, Staczek P. | Int J Mol Sci | 10.3390/ijms22083881 | 2021 | |
| Metabolism | The unfoldase ClpC1 of Mycobacterium tuberculosis regulates the expression of a distinct subset of proteins having intrinsically disordered termini. | Lunge A, Gupta R, Choudhary E, Agarwal N. | J Biol Chem | 10.1074/jbc.ra120.013456 | 2020 | |
| LytB1 and LytB2 of Mycobacterium tuberculosis Are Not Genetically Redundant. | Brown AC, Kokoczka R, Parish T. | PLoS One | 10.1371/journal.pone.0135638 | 2015 | | |
| Pathogenicity | A Target-Based Whole Cell Screen Approach To Identify Potential Inhibitors of Mycobacterium tuberculosis Signal Peptidase. | Bonnett SA, Ollinger J, Chandrasekera S, Florio S, O'Malley T, Files M, Jee JA, Ahn J, Casey A, Ovechkina Y, Roberts D, Korkegian A, Parish T. | ACS Infect Dis | 10.1021/acsinfecdis.6b00075 | 2016 | |
| Novel 3,4-Methylenedioxybenzene Scaffold Incorporated 1,3,5-Trisubstituted-2-pyrazolines: Synthesis, Characterization and Evaluation for Chemotherapeutic Activity. | Deshpande SR, Nagrale SN, Patil MV, Chavan PS. | Indian J Pharm Sci | 10.4103/0250-474x.151588 | 2015 | | |
| pncA Mutations in the Specimens from Extrapulmonary Tuberculosis. | Lee J, Yun YJ, Kqueen CY, Lee JH, Kim HY, Kim YR, Kook YH, Lee KH. | Tuberc Respir Dis (Seoul) | 10.4046/trd.2012.72.6.475 | 2012 | | |
| Metabolism | Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophages. | Billig S, Schneefeld M, Huber C, Grassl GA, Eisenreich W, Bange FC. | Sci Rep | 10.1038/s41598-017-05916-7 | 2017 | |
| Metabolism | Mycobacterium tuberculosis Rv0991c Is a Redox-Regulated Molecular Chaperone. | Becker SH, Ulrich K, Dhabaria A, Ueberheide B, Beavers W, Skaar EP, Iyer LM, Aravind L, Jakob U, Darwin KH. | mBio | 10.1128/mbio.01545-20 | 2020 | |
| WhyD tailors surface polymers to prevent premature bacteriolysis and direct cell elongation in Streptococcus pneumoniae. | Flores-Kim J, Dobihal GS, Bernhardt TG, Rudner DZ. | Elife | 10.7554/elife.76392 | 2022 | | |
| Metabolism | Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-beta and AIM2 inflammasome-dependent IL-1beta production via its ESX-1 secretion system. | Shah S, Bohsali A, Ahlbrand SE, Srinivasan L, Rathinam VA, Vogel SN, Fitzgerald KA, Sutterwala FS, Briken V. | J Immunol | 10.4049/jimmunol.1301331 | 2013 | |
| HyperVR: a hybrid deep ensemble learning approach for simultaneously predicting virulence factors and antibiotic resistance genes. | Ji B, Pi W, Liu W, Liu Y, Cui Y, Zhang X, Peng S. | NAR Genom Bioinform | 10.1093/nargab/lqad012 | 2023 | | |
| Widespread use of incorrect PCR ramp rate negatively impacts multidrug-resistant tuberculosis diagnosis (MTBDRplus). | Derendinger B, de Vos M, Nathavitharana RR, Dolby T, Simpson JA, van Helden PD, Warren RM, Theron G. | Sci Rep | 10.1038/s41598-018-21458-y | 2018 | | |
| Design and synthesis of quinazoline carboxylates against Gram-positive, Gram-negative, fungal pathogenic strains, and Mycobacterium tuberculosis. | Selvam TP, Sivakumar A, Prabhu PP. | J Pharm Bioallied Sci | 10.4103/0975-7406.142960 | 2014 | | |
| Pathogenicity | Emergence of ofloxacin resistance in Mycobacterium tuberculosis clinical isolates from China as determined by gyrA mutation analysis using denaturing high-pressure liquid chromatography and DNA sequencing. | Shi R, Zhang J, Li C, Kazumi Y, Sugawara I. | J Clin Microbiol | 10.1128/jcm.01916-06 | 2006 | |
| Enzymology | A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis. | Witek MA, Kuiper EG, Minten E, Crispell EK, Conn GL. | J Biol Chem | 10.1074/jbc.m116.752659 | 2017 | |
| Enzymology | A molecular platform for the diagnosis of multidrug-resistant and pre-extensively drug-resistant tuberculosis based on single nucleotide polymorphism mutations present in Colombian isolates of Mycobacterium tuberculosis. | Martinez LM, Castro GP, Guerrero MI. | Mem Inst Oswaldo Cruz | 10.1590/0074-02760150306 | 2016 | |
| Enzymology | Performance monitoring of mycobacterium tuberculosis dried culture spots for use with the GeneXpert system within a national program in South Africa. | Gous N, Cunningham B, Kana B, Stevens W, Scott LE. | J Clin Microbiol | 10.1128/jcm.01715-13 | 2013 | |
| Transcriptome | DeepVF: a deep learning-based hybrid framework for identifying virulence factors using the stacking strategy. | Xie R, Li J, Wang J, Dai W, Leier A, Marquez-Lago TT, Akutsu T, Lithgow T, Song J, Zhang Y. | Brief Bioinform | 10.1093/bib/bbaa125 | 2021 | |
| Pathogenicity | Evaluation of mycobactericidal activity of selected chemical disinfectants and antiseptics according to European standards. | Bocian E, Grzybowska W, Tyski S. | Med Sci Monit | 10.12659/msm.890175 | 2014 | |
| Novel Approach for Transdermal Delivery of Rifampicin to Induce Synergistic Antimycobacterial Effects Against Cutaneous and Systemic Tuberculosis Using a Cationic Nanoemulsion Gel. | Hussain A, Altamimi MA, Alshehri S, Imam SS, Shakeel F, Singh SK, Singh SK. | Int J Nanomedicine | 10.2147/ijn.s236277 | 2020 | | |
| Metabolism | Role of the Mmr efflux pump in drug resistance in Mycobacterium tuberculosis. | Rodrigues L, Villellas C, Bailo R, Viveiros M, Ainsa JA. | Antimicrob Agents Chemother | 10.1128/aac.01482-12 | 2013 | |
| Pathogenicity | Detection of first- and second-line drug resistance in Mycobacterium tuberculosis clinical isolates by pyrosequencing. | Engstrom A, Morcillo N, Imperiale B, Hoffner SE, Jureen P. | J Clin Microbiol | 10.1128/jcm.06664-11 | 2012 | |
| Dissecting the conformational complexity and mechanism of a bacterial heme transporter. | Wu D, Mehdipour AR, Finke F, Goojani HG, Groh RR, Grund TN, Reichhart TMB, Zimmermann R, Welsch S, Bald D, Shepherd M, Hummer G, Safarian S. | Nat Chem Biol | 10.1038/s41589-023-01314-5 | 2023 | | |
| Metabolism | Identification of Rv3852 as an Agrimophol-Binding Protein in Mycobacterium tuberculosis. | Zhao N, Sun M, Burns-Huang K, Jiang X, Ling Y, Darby C, Ehrt S, Liu G, Nathan C. | PLoS One | 10.1371/journal.pone.0126211 | 2015 | |
| Pathogenicity | Methionine sulfoximine resistance in Mycobacterium tuberculosis is due to a single nucleotide deletion resulting in increased expression of the major glutamine synthetase, GlnA1. | Carroll P, Waddell SJ, Butcher PD, Parish T. | Microb Drug Resist | 10.1089/mdr.2010.0125 | 2011 | |
| Metabolism | Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability. | Rucker N, Billig S, Bucker R, Jahn D, Wittmann C, Bange FC. | J Bacteriol | 10.1128/jb.00259-15 | 2015 | |
| Enzymology | Analytical and Clinical Evaluation of the Epistem Genedrive Assay for Detection of Mycobacterium tuberculosis. | Shenai S, Armstrong DT, Valli E, Dolinger DL, Nakiyingi L, Dietze R, Dalcolmo MP, Nicol MP, Zemanay W, Manabe Y, Hadad DJ, Marques-Rodrigues P, Palaci M, Peres RL, Gaeddert M, Armakovitch S, Nonyane BA, Denkinger CM, Banada P, Joloba ML, Ellner J, Boehme C, Alland D, Dorman SE. | J Clin Microbiol | 10.1128/jcm.02847-15 | 2016 | |
| Metabolism | Chemical activation of adenylyl cyclase Rv1625c inhibits growth of Mycobacterium tuberculosis on cholesterol and modulates intramacrophage signaling. | Johnson RM, Bai G, DeMott CM, Banavali NK, Montague CR, Moon C, Shekhtman A, VanderVen B, McDonough KA. | Mol Microbiol | 10.1111/mmi.13701 | 2017 | |
| Pilot study of a rapid and minimally instrumented sputum sample preparation method for molecular diagnosis of tuberculosis. | Ferguson TM, Weigel KM, Lakey Becker A, Ontengco D, Narita M, Tolstorukov I, Doebler R, Cangelosi GA, Niemz A. | Sci Rep | 10.1038/srep19541 | 2016 | | |
| Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages. | Dupont M, Souriant S, Balboa L, Vu Manh TP, Pingris K, Rousset S, Cougoule C, Rombouts Y, Poincloux R, Ben Neji M, Allers C, Kaushal D, Kuroda MJ, Benet S, Martinez-Picado J, Izquierdo-Useros N, Sasiain MDC, Maridonneau-Parini I, Neyrolles O, Verollet C, Lugo-Villarino G. | Elife | 10.7554/elife.52535 | 2020 | | |
| Effectiveness of BCG vaccination to aged mice. | Ito T, Takii T, Maruyama M, Hayashi D, Wako T, Asai A, Horita Y, Taniguchi K, Yano I, Yamamoto S, Onozaki K. | Immun Ageing | 10.1186/1742-4933-7-12 | 2010 | | |
| Synthesis and anti-tubercular activity of 3-substituted benzo[b]thiophene-1,1-dioxides. | Chandrasekera NS, Bailey MA, Files M, Alling T, Florio SK, Ollinger J, Odingo JO, Parish T. | PeerJ | 10.7717/peerj.612 | 2014 | | |
| Mycobacterium tuberculosis pellicles express unique proteins recognized by the host humoral response. | Kerns PW, Ackhart DF, Basaraba RJ, Leid JG, Shirtliff ME. | Pathog Dis | 10.1111/2049-632x.12142 | 2014 | | |
| Pathogenicity | Pyrazinamide resistance and pncA gene mutations in Mycobacterium tuberculosis. | Jureen P, Werngren J, Toro JC, Hoffner S. | Antimicrob Agents Chemother | 10.1128/aac.00110-08 | 2008 | |
| The OxyR and SoxR transcriptional regulators are involved in a broad oxidative stress response in Paraburkholderia xenovorans LB400. | Mendez V, Rodriguez-Castro L, Duran RE, Padron G, Seeger M. | Biol Res | 10.1186/s40659-022-00373-7 | 2022 | | |
| Both phthiocerol dimycocerosates and phenolic glycolipids are required for virulence of Mycobacterium marinum. | Yu J, Tran V, Li M, Huang X, Niu C, Wang D, Zhu J, Wang J, Gao Q, Liu J, Liu J. | Infect Immun | 10.1128/iai.06370-11 | 2012 | | |
| Metabolism | Comparative analysis of homologous aminopeptidase PepN from pathogenic and non-pathogenic mycobacteria reveals divergent traits. | Sharma N, Aggarwal S, Kumar S, Sharma R, Choudhury K, Singh N, Jayaswal P, Goel R, Wajid S, Yadav AK, Atmakuri K. | PLoS One | 10.1371/journal.pone.0215123 | 2019 | |
| In silico study of 4-phosphorylated derivatives of 1,3-oxazole as inhibitors of Candida albicans fructose-1,6-bisphosphate aldolase II. | Semenyuta IV, Kobzar OL, Hodyna DM, Brovarets VS, Metelytsia LO. | Heliyon | 10.1016/j.heliyon.2019.e01462 | 2019 | | |
| Development of a highly biocompatible antituberculosis nanodelivery formulation based on para-aminosalicylic acid-zinc layered hydroxide nanocomposites. | Saifullah B, Arulselvan P, El Zowalaty ME, Fakurazi S, Webster TJ, Geilich B, Hussein MZ. | ScientificWorldJournal | 10.1155/2014/401460 | 2014 | | |
| Pathogenicity | Isoniazid could be used for antibiotic-loaded bone cement for musculoskeletal tuberculosis: an in vitro study. | Han CD, Oh T, Cho SN, Yang JH, Park KK. | Clin Orthop Relat Res | 10.1007/s11999-013-2899-5 | 2013 | |
| Genetic dissection of mycobacterial biofilms. | Ojha AK, Jacobs WR, Hatfull GF. | Methods Mol Biol | 10.1007/978-1-4939-2450-9_12 | 2015 | | |
| Pathogenicity | Resistance levels and rpoB gene mutations among in vitro-selected rifampin-resistant Mycobacterium tuberculosis mutants. | Huitric E, Werngren J, Jureen P, Hoffner S. | Antimicrob Agents Chemother | 10.1128/aac.00303-06 | 2006 | |
| Metabolism | EspR-dependent ESAT-6 Protein Secretion of Mycobacterium tuberculosis Requires the Presence of Virulence Regulator PhoP. | Anil Kumar V, Goyal R, Bansal R, Singh N, Sevalkar RR, Kumar A, Sarkar D. | J Biol Chem | 10.1074/jbc.m116.746289 | 2016 | |
| An Overview of the Structure-Activity Relationship in Novel Antimicrobial Thiazoles Clubbed with Various Heterocycles (2017-2023). | Ungureanu D, Tiperciuc B, Nastasa C, Ionut I, Marc G, Oniga I, Oniga O. | Pharmaceutics | 10.3390/pharmaceutics16010089 | 2024 | | |
| A Canine-Directed Chimeric Multi-Epitope Vaccine Induced Protective Immune Responses in BALB/c Mice Infected with Leishmania infantum. | Agallou M, Margaroni M, Kotsakis SD, Karagouni E. | Vaccines (Basel) | 10.3390/vaccines8030350 | 2020 | | |
| Detection of rifampicin resistance in Mycobacterium tuberculosis by padlock probes and magnetic nanobead-based readout. | Engstrom A, Zardan Gomez de la Torre T, Stromme M, Nilsson M, Herthnek D. | PLoS One | 10.1371/journal.pone.0062015 | 2013 | | |
| Metabolism | The copper-responsive RicR regulon contributes to Mycobacterium tuberculosis virulence. | Shi X, Festa RA, Ioerger TR, Butler-Wu S, Sacchettini JC, Darwin KH, Samanovic MI. | mBio | 10.1128/mbio.00876-13 | 2014 | |
| Abnormal immune responses in persons with previous extrapulmonary tuberculosis in an in vitro model that simulates in vivo infection with Mycobacterium tuberculosis. | Fiske CT, de Almeida AS, Shintani AK, Kalams SA, Sterling TR. | Clin Vaccine Immunol | 10.1128/cvi.00221-12 | 2012 | | |
| Role for NOD2 in Mycobacterium tuberculosis-induced iNOS expression and NO production in human macrophages. | Landes MB, Rajaram MV, Nguyen H, Schlesinger LS. | J Leukoc Biol | 10.1189/jlb.3a1114-557r | 2015 | | |
| Screening ancient tuberculosis with qPCR: challenges and opportunities. | Harkins KM, Buikstra JE, Campbell T, Bos KI, Johnson ED, Krause J, Stone AC. | Philos Trans R Soc Lond B Biol Sci | 10.1098/rstb.2013.0622 | 2015 | | |
| Pathogenicity | Antitubercular activity of disulfiram, an antialcoholism drug, against multidrug- and extensively drug-resistant Mycobacterium tuberculosis isolates. | Horita Y, Takii T, Yagi T, Ogawa K, Fujiwara N, Inagaki E, Kremer L, Sato Y, Kuroishi R, Lee Y, Makino T, Mizukami H, Hasegawa T, Yamamoto R, Onozaki K. | Antimicrob Agents Chemother | 10.1128/aac.06445-11 | 2012 | |
| Phenotype | Molecular characterization of clinical isolates of Mycobacterium tuberculosis and their association with phenotypic virulence in human macrophages. | Wong KC, Leong WM, Law HK, Ip KF, Lam JT, Yuen KY, Ho PL, Tse WS, Weng XH, Zhang WH, Chen S, Yam WC. | Clin Vaccine Immunol | 10.1128/cvi.00190-07 | 2007 | |
| Metabolism | M. tuberculosis-Initiated Human Mannose Receptor Signaling Regulates Macrophage Recognition and Vesicle Trafficking by FcRgamma-Chain, Grb2, and SHP-1. | Rajaram MVS, Arnett E, Azad AK, Guirado E, Ni B, Gerberick AD, He LZ, Keler T, Thomas LJ, Lafuse WP, Schlesinger LS. | Cell Rep | 10.1016/j.celrep.2017.09.034 | 2017 | |
| Metabolism | Kinetic modelling of GlmU reactions - prioritization of reaction for therapeutic application. | Singh VK, Das K, Seshadri K. | PLoS One | 10.1371/journal.pone.0043969 | 2012 | |
| Phylogeny | Traditional Medicinal Plants as a Source of Antituberculosis Drugs: A System Review. | Xu Y, Liang B, Kong C, Sun Z. | Biomed Res Int | 10.1155/2021/9910365 | 2021 | |
| Metabolism | Induced ectopic expression of HigB toxin in Mycobacterium tuberculosis results in growth inhibition, reduced abundance of a subset of mRNAs and cleavage of tmRNA. | Schuessler DL, Cortes T, Fivian-Hughes AS, Lougheed KE, Harvey E, Buxton RS, Davis EO, Young DB. | Mol Microbiol | 10.1111/mmi.12358 | 2013 | |
| A Deep Learning Approach to Antibiotic Discovery. | Stokes JM, Yang K, Swanson K, Jin W, Cubillos-Ruiz A, Donghia NM, MacNair CR, French S, Carfrae LA, Bloom-Ackermann Z, Tran VM, Chiappino-Pepe A, Badran AH, Andrews IW, Chory EJ, Church GM, Brown ED, Jaakkola TS, Barzilay R, Collins JJ. | Cell | 10.1016/j.cell.2020.01.021 | 2020 | | |
| A two-step strategy for the complementation of M. tuberculosis mutants. | Movahedzadeh F, Frita R, Gutka HJ. | Genet Mol Biol | 10.1590/s1415-47572011000200020 | 2011 | | |
| The promoter of Rv0560c is induced by salicylate and structurally-related compounds in Mycobacterium tuberculosis. | Schuessler DL, Parish T. | PLoS One | 10.1371/journal.pone.0034471 | 2012 | | |
| Metabolism | Comprehensive plasma proteomic profiling reveals biomarkers for active tuberculosis. | Garay-Baquero DJ, White CH, Walker NF, Tebruegge M, Schiff HF, Ugarte-Gil C, Morris-Jones S, Marshall BG, Manousopoulou A, Adamson J, Vallejo AF, Bielecka MK, Wilkinson RJ, Tezera LB, Woelk CH, Garbis SD, Elkington P. | JCI Insight | 10.1172/jci.insight.137427 | 2020 | |
| Testing tuberculosis drug efficacy in a zebrafish high-throughput translational medicine screen. | Ordas A, Raterink RJ, Cunningham F, Jansen HJ, Wiweger MI, Jong-Raadsen S, Bos S, Bates RH, Barros D, Meijer AH, Vreeken RJ, Ballell-Pages L, Dirks RP, Hankemeier T, Spaink HP. | Antimicrob Agents Chemother | 10.1128/aac.03588-14 | 2015 | | |
| Posttreatment reactivation of tuberculosis in mice caused by Mycobacterium tuberculosis disrupted in mce1R. | Cheigh CI, Senaratne R, Uchida Y, Casali N, Kendall LV, Riley LW. | J Infect Dis | 10.1086/655224 | 2010 | | |
| Pathogenicity | Activity of pyrazinamide in a murine model against Mycobacterium tuberculosis isolates with various levels of in vitro susceptibility. | Klemens SP, Sharpe CA, Cynamon MH. | Antimicrob Agents Chemother | 10.1128/aac.40.1.14 | 1996 | |
| The Effect of Conjugation of Ciprofloxacin and Moxifloxacin with Fatty Acids on Their Antibacterial and Anticancer Activity. | Chrzanowska A, Struga M, Roszkowski P, Kolinski M, Kmiecik S, Jalbrzykowska K, Zabost A, Stefanska J, Augustynowicz-Kopec E, Wrzosek M, Bielenica A. | Int J Mol Sci | 10.3390/ijms23116261 | 2022 | | |
| Metabolism | Identification of Comamonas testosteroni as an androgen degrader in sewage. | Chen YL, Wang CH, Yang FC, Ismail W, Wang PH, Shih CJ, Wu YC, Chiang YR. | Sci Rep | 10.1038/srep35386 | 2016 | |
| Metabolism | A common mechanism of inhibition of the Mycobacterium tuberculosis mycolic acid biosynthetic pathway by isoxyl and thiacetazone. | Grzegorzewicz AE, Kordulakova J, Jones V, Born SE, Belardinelli JM, Vaquie A, Gundi VA, Madacki J, Slama N, Laval F, Vaubourgeix J, Crew RM, Gicquel B, Daffe M, Morbidoni HR, Brennan PJ, Quemard A, McNeil MR, Jackson M. | J Biol Chem | 10.1074/jbc.m112.400994 | 2012 | |
| Rat neutrophils prevent the development of tuberculosis. | Sugawara I, Udagawa T, Yamada H. | Infect Immun | 10.1128/iai.72.3.1804-1806.2004 | 2004 | | |
| Pathogenicity | Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB. | Chandrasekera NS, Berube BJ, Shetye G, Chettiar S, O'Malley T, Manning A, Flint L, Awasthi D, Ioerger TR, Sacchettini J, Masquelin T, Hipskind PA, Odingo J, Parish T. | ACS Infect Dis | 10.1021/acsinfecdis.7b00112 | 2017 | |
| Phylogeny | Importance of confirming data on the in vivo efficacy of novel antibacterial drug regimens against various strains of Mycobacterium tuberculosis. | De Groote MA, Gruppo V, Woolhiser LK, Orme IM, Gilliland JC, Lenaerts AJ. | Antimicrob Agents Chemother | 10.1128/aac.05701-11 | 2012 | |
| Metabolism | Mycobacterium tuberculosis RecG binds and unwinds model DNA substrates with a preference for Holliday junctions. | Zegeye ED, Balasingham SV, Laerdahl JK, Homberset H, Tonjum T. | Microbiology (Reading) | 10.1099/mic.0.058693-0 | 2012 | |
| Improved polyacrylamide-based artificial sputum with formalin-fixed tubercle bacilli for training of tuberculosis microscopists. | Yamada H, Mitarai S, Wahyunitisari MR, Mertaniasih NM, Sugamoto T, Chikamatsu K, Aono A, Matsumoto H, Fujiki A. | J Clin Microbiol | 10.1128/jcm.00370-11 | 2011 | | |
| Edible Leafy Plants from Mexico as Sources of Antioxidant Compounds, and Their Nutritional, Nutraceutical and Antimicrobial Potential: A Review. | Mateos-Maces L, Chavez-Servia JL, Vera-Guzman AM, Aquino-Bolanos EN, Alba-Jimenez JE, Villagomez-Gonzalez BB. | Antioxidants (Basel) | 10.3390/antiox9060541 | 2020 | | |
| Metabolism | Mycobacterium tuberculosis infection of dendritic cells leads to partially caspase-1/11-independent IL-1beta and IL-18 secretion but not to pyroptosis. | Abdalla H, Srinivasan L, Shah S, Mayer-Barber KD, Sher A, Sutterwala FS, Briken V. | PLoS One | 10.1371/journal.pone.0040722 | 2012 | |
| Metabolism | Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB. | Cleghorn LAT, Ray PC, Odingo J, Kumar A, Wescott H, Korkegian A, Masquelin T, Lopez Moure A, Wilson C, Davis S, Huggett M, Turner P, Smith A, Epemolu O, Zuccotto F, Riley J, Scullion P, Shishikura Y, Ferguson L, Rullas J, Guijarro L, Read KD, Green SR, Hipskind P, Parish T, Wyatt PG. | J Med Chem | 10.1021/acs.jmedchem.8b00172 | 2018 | |
| Metabolism | Biosynthetic origin of the galactosamine substituent of Arabinogalactan in Mycobacterium tuberculosis. | Skovierova H, Larrouy-Maumus G, Pham H, Belanova M, Barilone N, Dasgupta A, Mikusova K, Gicquel B, Gilleron M, Brennan PJ, Puzo G, Nigou J, Jackson M. | J Biol Chem | 10.1074/jbc.m110.188110 | 2010 | |
| The efflux pump inhibitor timcodar improves the potency of antimycobacterial agents. | Grossman TH, Shoen CM, Jones SM, Jones PL, Cynamon MH, Locher CP. | Antimicrob Agents Chemother | 10.1128/aac.04271-14 | 2015 | | |
| Metabolism | A multicopper oxidase is required for copper resistance in Mycobacterium tuberculosis. | Rowland JL, Niederweis M. | J Bacteriol | 10.1128/jb.00546-13 | 2013 | |
| Starvation survival response of Mycobacterium tuberculosis. | Parish T. | J Bacteriol | 10.1128/jb.185.22.6702-6706.2003 | 2003 | | |
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| Enzymology | Inositol monophosphate phosphatase genes of Mycobacterium tuberculosis. | Movahedzadeh F, Wheeler PR, Dinadayala P, Av-Gay Y, Parish T, Daffe M, Stoker NG. | BMC Microbiol | 10.1186/1471-2180-10-50 | 2010 | |
| Metabolism | Trehalose 6,6'-dimycolate on the surface of Mycobacterium tuberculosis modulates surface marker expression for antigen presentation and costimulation in murine macrophages. | Kan-Sutton C, Jagannath C, Hunter RL. | Microbes Infect | 10.1016/j.micinf.2008.10.006 | 2009 | |
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| Inhibition of the Plasma-Membrane-Associated Serine Protease Cathepsin G by Mycobacterium tuberculosis Rv3364c Suppresses Caspase-1 and Pyroptosis in Macrophages. | Danelishvili L, Everman JL, McNamara MJ, Bermudez LE. | Front Microbiol | 10.3389/fmicb.2011.00281 | 2011 | | |
| A novel inhibitor of gyrase B is a potent drug candidate for treatment of tuberculosis and nontuberculosis mycobacterial infections. | Locher CP, Jones SM, Hanzelka BL, Perola E, Shoen CM, Cynamon MH, Ngwane AH, Wiid IJ, van Helden PD, Betoudji F, Nuermberger EL, Thomson JA. | Antimicrob Agents Chemother | 10.1128/aac.04347-14 | 2015 | | |
| Metabolism | A point mutation in the two-component regulator PhoP-PhoR accounts for the absence of polyketide-derived acyltrehaloses but not that of phthiocerol dimycocerosates in Mycobacterium tuberculosis H37Ra. | Chesne-Seck ML, Barilone N, Boudou F, Gonzalo Asensio J, Kolattukudy PE, Martin C, Cole ST, Gicquel B, Gopaul DN, Jackson M. | J Bacteriol | 10.1128/jb.01465-07 | 2008 | |
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| Metabolism | Extracellular vesicles produced by human and animal Staphylococcus aureus strains share a highly conserved core proteome. | Tartaglia NR, Nicolas A, Rodovalho VR, Luz BSRD, Briard-Bion V, Krupova Z, Thierry A, Coste F, Burel A, Martin P, Jardin J, Azevedo V, Le Loir Y, Guedon E. | Sci Rep | 10.1038/s41598-020-64952-y | 2020 | |
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| Metabolism | Nucleotide-oligomerizing domain-1 (NOD1) receptor activation induces pro-inflammatory responses and autophagy in human alveolar macrophages. | Juarez E, Carranza C, Hernandez-Sanchez F, Loyola E, Escobedo D, Leon-Contreras JC, Hernandez-Pando R, Torres M, Sada E. | BMC Pulm Med | 10.1186/1471-2466-14-152 | 2014 | |
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| Enzymology | A Novel Quorum-Quenching N-Acylhomoserine Lactone Acylase from Acidovorax sp. Strain MR-S7 Mediates Antibiotic Resistance. | Kusada H, Tamaki H, Kamagata Y, Hanada S, Kimura N. | Appl Environ Microbiol | 10.1128/aem.00080-17 | 2017 | |
| Expression of cathelicidin LL-37 during Mycobacterium tuberculosis infection in human alveolar macrophages, monocytes, neutrophils, and epithelial cells. | Rivas-Santiago B, Hernandez-Pando R, Carranza C, Juarez E, Contreras JL, Aguilar-Leon D, Torres M, Sada E. | Infect Immun | 10.1128/iai.01218-07 | 2008 | | |
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| Pathogenicity | A novel metabolite of antituberculosis therapy demonstrates host activation of isoniazid and formation of the isoniazid-NAD+ adduct. | Mahapatra S, Woolhiser LK, Lenaerts AJ, Johnson JL, Eisenach KD, Joloba ML, Boom WH, Belisle JT. | Antimicrob Agents Chemother | 10.1128/aac.05486-11 | 2012 | |
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How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive174194.20251217.10
When using BacDive for research please cite the following paper
BacDive in 2025: the core database for prokaryotic strain data
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