Actinomadura madurae (DSM 43067, ATCC 19425, CCM 136)

Name: Actinomadura madurae (DSM 43067, ATCC 19425, CCM 136)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16933

Type strain

Culture col. no. DSM 43067 ATCC 19425 CCM 136 IAM 14277 IFO 14623 22 more

NCBI tax ID(s) 1220569 1993

Special Collections DSMZ CCUG JCM KCTC CIP Wink compendium JMRC

History DSMZ <- CCM (Nocardia madurae) <- R.E. Gordon, IMRU <- A.E. des Area Leao, Inst. Oswaldo Cruz, Rio de Janeiro JCM <-- KCC A-0238 <-- IFO 13909 <-- IMRU 507 <-- P. Thibault. JCM <-- DSM 43067 <-- CCM 136 <-- R. E. Gordon 1190 <-- A. E. des Area Leao. CIP <- 1988, JCM <- DSM <- CCM <- R.E. Gordon <- A.E. des Area Leao, Nocardia madurae

Links

Actinomadura madurae DSM 43067 is an obligate aerobe, Gram-positive, rod-shaped human pathogen that builds an aerial mycelium and was isolated from mycetoma pedis tissue.

Gram-positive rod-shaped obligate aerobe human pathogen genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 36984

MTCC 1120,ATCC 19425,NCTC 5654,CCUG 32944,CCM 136,DSM 43067,CIP 105487,IFO 14623,IMET 9585,JCM 7436,NRRL B-3843,VKM Ac-809,IAM 14277,JCM 3238,CCRC 13639,NCIMB 13469,IFO13909,JCM 7736,CECT 3043,KCTC 9192,NBRC 13909,NBRC 14623,HAMBI 1926,BCRC 13639,KACC 20031,NBIMCC 1605,CGMCC 4.1224

@ref 20215

Last LPSN update 2026-05-29 08:28:53

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Streptosporangiales

Family Thermomonosporaceae

Genus Actinomadura

Species Actinomadura madurae

Full scientific name Actinomadura madurae (Vincent 1894) Lechevalier and Lechevalier 1970 (Approved Lists 1980)

Synonyms (1)

"Streptothrix madurae"

BacDive ID	Other strains from **Actinomadura madurae** (15)	Type strain
16934	A. madurae IHM 1390, DSM 43121, IMRU 754
16935	A. madurae A.292(9972), DSM 43122, IMRU 780
16936	A. madurae 812, DSM 43123, IMRU 1260
16937	A. madurae Pirie, DSM 43236, NCTC 1070
16938	A. madurae A 32, DSM 43380, IP 364
16939	A. madurae A 124, B-2, DSM 43381, IMET 7144, IMRU 1136
16940	A. madurae 492-10, A 196, DSM 44005, IMET 492-10, IMET ...
16941	A. madurae Sal 1, DSM 46006, IMET 7145
16942	A. madurae A 126, RG 1091, DSM 46007, IMET 7146
16943	A. madurae 906-28, DSM 46181, IMET 9595
16944	A. madurae 905-223, DSM 46182, IMET 9597
128261	A. madurae ST028326(HKI), JA06665, Baldacci24b,
128262	A. madurae ST028388(HKI), 1118-016,
136905	A. madurae A260, 306, CIP 55.68
136906	A. madurae 2593, 339, CIP 55.73

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
125439	positive		99.112
125439			92.381
120745	positive	rod-shaped

Colony morphology

@ref	Colony color	Incubation period	Medium used
19936	Beige (1001)	10-14 days	ISP 2
19936	Beige (1001)	10-14 days	ISP 3
19936	Beige (1001)	10-14 days	ISP 4
19936	Beige (1001)	10-14 days	ISP 5
19936	Beige (1001)	10-14 days	ISP 6
19936	Beige (1001)	10-14 days	ISP 7

Multicellular morphology

@ref	Complex name	Complex color	Medium name
19936	Aerial Mycelium	White	ISP 2
19936			ISP 3
19936			ISP 4
19936			ISP 5
19936			ISP 6
19936			ISP 7

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
19936	ISP 2		Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19936	ISP 3		Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19936	ISP 4		Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19936	ISP 5		Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19936	ISP 6		Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19936	ISP 7		Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
39304	MEDIUM 3 - Columbia agar		Columbia agar (39.000 g);distilled water (1000.000 ml)
10730	GLYCEROL-SOIL MEDIUM (DSMZ Medium 80)	Medium recipe at MediaDive	Name: GLYCEROL-SOIL MEDIUM (DSMZ Medium 80) Composition: Glycerol 20.0 g/l Agar 15.0 g/l Peptone 5.0 g/l Beef extract 3.0 g/l Soil extract Distilled water
10730	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)	Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
120745	CIP Medium 236	Medium recipe at CIP
120745	CIP Medium 3	Medium recipe at CIP
120745	CIP Medium 57	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
10730	positive	growth	37
19936	positive	optimum	37
39304	positive	growth	37
67770	positive	growth	37
120745	positive	growth	22-41
120745	negative	growth	5
120745	negative	growth	15

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
120745	obligate aerobe
125438	aerobe	91.861
125439	obligate aerobe	99.161

Spore formation

@ref	Spore formation	Confidence
125438		90.014

Compound production

@ref	Compound
10730	nonyl prodigiosine
10730	undecyl prodigiosine
19936	Maduropeptin
19936	Prodiogisine
19936	Simaomicin

Halophily

@ref	Salt	Growth	Tested relation	Concentration
19936	NaCl	positive	maximum	2.5 %
120745	NaCl	positive	growth	0-2 %
120745	NaCl		growth	4 %
120745	NaCl		growth	6 %
120745	NaCl		growth	8 %
120745	NaCl		growth	10 %

Observation

67770

Observationquinones: MK-9(H₆), MK-9(H₈)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
19936	22599 ChEBI	arabinose	+
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
19936	62968 ChEBI	cellulose	-
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
120745	4853 ChEBI	esculin	+	hydrolysis
19936	28757 ChEBI	fructose	+
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
19936	17234 ChEBI	glucose	+
120745	17234 ChEBI	glucose	+	degradation
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68368	25094 ChEBI	lysine	-	degradation	from API 20E
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
19936	29864 ChEBI	mannitol	-
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
19936	17268 ChEBI	myo-inositol	-
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
120745	17632 ChEBI	nitrate	+	reduction
120745	17632 ChEBI	nitrate	-	respiration
120745	16301 ChEBI	nitrite	-	reduction
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
19936	16634 ChEBI	raffinose	-
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
19936	26546 ChEBI	rhamnose	-
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
19936	17992 ChEBI	sucrose	-
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68368	16199 ChEBI	urea	-	hydrolysis	from API 20E
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid
19936	18222 ChEBI	xylose	+

Antibiotic resistance

@ref	Metabolite	Is sensitive	Is resistant
120745	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite
68368	15688 ChEBI	acetoin	from API 20E
68368	16136 ChEBI	hydrogen sulfide	from API 20E
120745	35581 ChEBI	indole
68368	35581 ChEBI	indole	from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test	Indole test
120745	15688 ChEBI	acetoin	-
68368	15688 ChEBI	acetoin	-			from API 20E
120745	17234 ChEBI	glucose		-
68368	35581 ChEBI	indole			-	from API 20E

Enzymes

@ref	Value	Activity	Ec
120745	alcohol dehydrogenase	+	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	+	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
120745	amylase	-
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68382	beta-galactosidase	-	3.2.1.23	from API zym
120745	beta-galactosidase	-	3.2.1.23
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68382	beta-glucuronidase	-	3.2.1.31	from API zym
120745	caseinase	+	3.4.21.50
120745	catalase	+	1.11.1.6
120745	DNase	-
68382	esterase lipase (C 8)	+		from API zym
120745	gamma-glutamyltransferase	+	2.3.2.2
120745	gelatinase	+
68368	gelatinase	+		from API 20E
120745	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
120745	lipase	-
68382	lipase (C 14)	-		from API zym
120745	lysine decarboxylase	-	4.1.1.18
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
120745	ornithine decarboxylase	-	4.1.1.17
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
120745	oxidase	-
120745	phenylalanine ammonia-lyase	-	4.3.1.24
68382	trypsin	-	3.4.21.4	from API zym
120745	tryptophan deaminase	-
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
120745	tween esterase	-
120745	urease	-	3.5.1.5
68368	urease	-	3.5.1.5	from API 20E

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	resorcinol degradation	100	2 of 2
66794	4-hydroxymandelate degradation	100	9 of 9
66794	threonine metabolism	100	10 of 10
66794	adipate degradation	100	2 of 2
66794	lipoate biosynthesis	100	5 of 5
66794	gallate degradation	100	5 of 5
66794	cardiolipin biosynthesis	100	7 of 7
66794	Entner Doudoroff pathway	100	10 of 10
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	ethylmalonyl-CoA pathway	100	5 of 5
66794	ethanol fermentation	100	2 of 2
66794	propanol degradation	100	7 of 7
66794	acetate fermentation	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	butanoate fermentation	100	4 of 4
66794	urea cycle	100	13 of 13
66794	methylglyoxal degradation	100	5 of 5
66794	ppGpp biosynthesis	100	4 of 4
66794	enterobactin biosynthesis	100	3 of 3
66794	palmitate biosynthesis	100	22 of 22
66794	starch degradation	100	10 of 10
66794	photosynthesis	100	14 of 14
66794	biotin biosynthesis	100	4 of 4
66794	3-chlorocatechol degradation	100	5 of 5
66794	daunorubicin biosynthesis	100	9 of 9
66794	folate polyglutamylation	100	1 of 1
66794	formaldehyde oxidation	100	3 of 3
66794	ceramide biosynthesis	100	1 of 1
66794	sulfopterin metabolism	100	4 of 4
66794	denitrification	100	2 of 2
66794	isoleucine metabolism	100	8 of 8
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	cellulose degradation	100	5 of 5
66794	suberin monomers biosynthesis	100	2 of 2
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	vitamin K metabolism	100	5 of 5
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	coenzyme A metabolism	100	4 of 4
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	flavin biosynthesis	93.33	14 of 15
66794	citric acid cycle	92.86	13 of 14
66794	heme metabolism	92.86	13 of 14
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	pentose phosphate pathway	90.91	10 of 11
66794	proline metabolism	90.91	10 of 11
66794	4-hydroxyphenylacetate degradation	90	9 of 10
66794	propionate fermentation	90	9 of 10
66794	phenol degradation	90	18 of 20
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	d-mannose degradation	88.89	8 of 9
66794	serine metabolism	88.89	8 of 9
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	87.5	7 of 8
66794	ketogluconate metabolism	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	glutathione metabolism	85.71	12 of 14
66794	pyrimidine metabolism	84.44	38 of 45
66794	tryptophan metabolism	84.21	32 of 38
66794	purine metabolism	84.04	79 of 94
66794	glycolate and glyoxylate degradation	83.33	5 of 6
66794	NAD metabolism	83.33	15 of 18
66794	alanine metabolism	82.76	24 of 29
66794	glycine betaine biosynthesis	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	myo-inositol biosynthesis	80	8 of 10
66794	3-phenylpropionate degradation	80	12 of 15
66794	peptidoglycan biosynthesis	80	12 of 15
66794	glycogen metabolism	80	4 of 5
66794	vitamin B12 metabolism	79.41	27 of 34
66794	glutamate and glutamine metabolism	78.57	22 of 28
66794	degradation of hexoses	77.78	14 of 18
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	aspartate and asparagine metabolism	77.78	7 of 9
66794	vitamin B1 metabolism	76.92	10 of 13
66794	glycolysis	76.47	13 of 17
66794	toluene degradation	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	degradation of sugar alcohols	75	12 of 16
66794	cyclohexanol degradation	75	3 of 4
66794	degradation of pentoses	75	21 of 28
66794	lysine metabolism	73.81	31 of 42
66794	non-pathway related	73.68	28 of 38
66794	methionine metabolism	73.08	19 of 26
66794	arginine metabolism	70.83	17 of 24
66794	oxidative phosphorylation	69.23	63 of 91
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	androgen and estrogen metabolism	68.75	11 of 16
66794	lipid metabolism	67.74	21 of 31
66794	acetoin degradation	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	selenocysteine biosynthesis	66.67	4 of 6
66794	cyanate degradation	66.67	2 of 3
66794	allantoin degradation	66.67	6 of 9
66794	cysteine metabolism	66.67	12 of 18
66794	histidine metabolism	65.52	19 of 29
66794	tetrahydrofolate metabolism	64.29	9 of 14
66794	tyrosine metabolism	64.29	9 of 14
66794	degradation of sugar acids	64	16 of 25
66794	d-xylose degradation	63.64	7 of 11
66794	metabolism of disaccharids	63.64	7 of 11
66794	carotenoid biosynthesis	63.64	14 of 22
66794	sulfate reduction	61.54	8 of 13
66794	hydrogen production	60	3 of 5
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	creatinine degradation	60	3 of 5
66794	coenzyme M biosynthesis	60	6 of 10
66794	arachidonate biosynthesis	60	3 of 5
66794	bile acid biosynthesis, neutral pathway	58.82	10 of 17
66794	ubiquinone biosynthesis	57.14	4 of 7
66794	polyamine pathway	56.52	13 of 23
66794	cholesterol biosynthesis	54.55	6 of 11
66794	ascorbate metabolism	54.55	12 of 22
66794	phosphatidylethanolamine bioynthesis	53.85	7 of 13
66794	ribulose monophosphate pathway	50	1 of 2
66794	quinate degradation	50	1 of 2
66794	glycine metabolism	50	5 of 10
66794	kanosamine biosynthesis II	50	1 of 2
66794	carnitine metabolism	50	4 of 8
66794	lactate fermentation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	CMP-KDO biosynthesis	50	2 of 4
66794	dTDPLrhamnose biosynthesis	50	4 of 8
66794	vitamin E metabolism	50	2 of 4
66794	pantothenate biosynthesis	50	3 of 6
66794	lipid A biosynthesis	44.44	4 of 9
66794	nitrate assimilation	44.44	4 of 9
66794	chlorophyll metabolism	44.44	8 of 18
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	mevalonate metabolism	42.86	3 of 7
66794	bacilysin biosynthesis	40	2 of 5
66794	O-antigen biosynthesis	40	2 of 5
66794	D-cycloserine biosynthesis	40	2 of 5
66794	arachidonic acid metabolism	38.89	7 of 18
66794	vitamin B6 metabolism	36.36	4 of 11
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	sulfoquinovose degradation	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	aclacinomycin biosynthesis	28.57	2 of 7
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12

Fatty acid profile

Metadata FA analysis

@ref

51271

Fatty acid	Percentage	ECL
C16:0	35.7	16
C18:1 ω9c	25	17.769
TBSA 10Me18:0	10.1	18.392
C16:1 ω7c	6.9	15.819
C18:0	4.7	18
C16:0 iso	4.4	15.626
C14:0	2.8	14
C18:2 ω6,9c/C18:0 ANTE	2.5	17.724
C16:1 ω9c	2.1	15.774
C17:0	1.7	17
C17:1 ω8c	1.7	16.792
C17:0 10-methyl	1.4	17.41
C15:0	1.1	15

API 20E

@ref	ONPG	ADH (Arg)	LDC (Lys)	ODC	CIT	H2S productionH2S	URE	TDA (Trp)	IND	Acetoin production (Voges Proskauer test)VP	GEL	GLU	MAN	INO	Sor	RHA	SAC	MEL	AMY	ARA	OX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	OF-O	OF-F
19936	-	-	-	-	-	-	-	-	-	-	+	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
19936	not determinedn.d.	+	-	+	-	+	-	-	-	+	+	+	-	-	-	-	+	-	-	-
120745	-	+	+	+	-	+	+	+	-	+	-	+	-	-	-	+	-	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
120745	not determinedn.d.	-	-	-	+/-	-	+/-	-	+/-	-	-	+/-	-	-	-	+/-	-	-	+/-	-	-	-	+/-	-	-	+/-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+/-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Disease	-
#Host Body-Site	#Limb	#Foot

Isolation

@ref	Sample type	Host species
10730	mycetoma pedis tissue
51271	Human foot,mycetoma	Homo sapiens
67770	Mycetoma of foot
120745	Mycetoma of foot

Taxonmaps

69479

Global distribution of 16S sequence X97889 (>99% sequence identity) for Actinomadura madurae from Microbeatlas

Aquatic Samples	2
Soil Samples	113
Animal Samples	3
Plant Samples	0
Total Samples	118

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
10730	2	Risk group (German classification) According to TRBA 466
19936	2	German classification According to TRBA 466
120745	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM4713082v1 assembly for Actinomadura madurae ATCC 19425	complete	GCA_047130825			1993	85.49
67770	IMG-taxon 2634166331 annotated assembly for Actinomadura madurae DSM 43067	scaffold	GCA_900115095	1993.7	2634166331	1993	60.66

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	A.madurae 16S rRNA gene	X97889	1445	1993
20218	Actinomadura madurae gene for 16S ribosomal RNA, partial sequence	D85468	1469	1993
20218	Actinomadura madurae 16S-23S ribosomal RNA intergenic spacer region, partial sequence	AF134103	455	1993
20218	Actinomadura madurae DNA for 16S rRNA, partial sequence	D50668	1341	1993
20218	Actinomadura madurae 16S ribosomal RNA gene sequence	U58527	1440	1993

GC content

@ref	GC-content (mol%)	Method
67770	72.1	genome sequence analysis
67770	68.2	thermal denaturation, midpoint method (Tm)
67770	68	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM4713082v1 assembly for Actinomadura madurae ATCC 19425
NCBI: GCA_047130825

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.16	no
125439	gram_stain	BacteriaNetⓘ	positive	99.11	no
125439	motility	BacteriaNetⓘ	no	92.38	no
125439	spore_formation	BacteriaNetⓘ	yes	87.69	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Actinomadura madurae strain DSM 43067
PATRIC: 1993.7

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	88.30	no
125438	anaerobic	anaerobicⓘ	no	94.09	yes
125438	spore-forming	spore-formingⓘ	yes	90.01	no
125438	aerobic	aerobicⓘ	yes	91.86	yes
125438	thermophilic	thermophileⓘ	no	95.36	yes
125438	flagellated	motile2+ⓘ	no	86.60	no

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	[Mycetoma in Somalia - results of a survey done from 1959 to 1964].	Destombes P, Mariat F, Rosati L, Segretain G.	Acta Trop		1977
	Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.	Strobel T, Al-Dilaimi A, Blom J, Gessner A, Kalinowski J, Luzhetska M, Puhler A, Szczepanowski R, Bechthold A, Ruckert C.	BMC Genomics	10.1186/1471-2164-13-465	2012
Phylogeny	Rapid PCR amplification of minimal enediyne polyketide synthase cassettes leads to a predictive familial classification model.	Liu W, Ahlert J, Gao Q, Wendt-Pienkowski E, Shen B, Thorson JS.	Proc Natl Acad Sci U S A	10.1073/pnas.2034291100	2003
Phylogeny	Biosynthetic potential of phylogenetically unique endophytic actinomycetes from tropical plants.	Janso JE, Carter GT.	Appl Environ Microbiol	10.1128/aem.02959-09	2010
Metabolism	Prodigiosin-like pigments from Actinomadura (Nocardia) pelletieri and Actinomadura madurae.	Gerber NN.	Appl Microbiol	10.1128/am.18.1.1-3.1969	1969
Enzymology	Sequence-based identification of aerobic actinomycetes.	Patel JB, Wallace RJ, Brown-Elliott BA, Taylor T, Imperatrice C, Leonard DG, Wilson RW, Mann L, Jost KC, Nachamkin I.	J Clin Microbiol	10.1128/jcm.42.6.2530-2540.2004	2004
	Resins and Gums in Historical Iatrosophia Texts from Cyprus - A Botanical and Medico-pharmacological Approach.	Lardos A, Prieto-Garcia J, Heinrich M.	Front Pharmacol	10.3389/fphar.2011.00032	2011
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
	Actinomadura welshii sp. nov., a New Mycetoma Agent in Mexico.	Vera-Cabrera L, Molina-Torres CA, Crane AE, Cantu-Alvarez MG, Aguilera-Valenciano MA, Gallardo-Rocha A, Escalante-Fuentes WG, Ocampo-Candiani J, Avanzi C.	PLoS Negl Trop Dis	10.1371/journal.pntd.0013016	2025
Phylogeny	Actinomadura maheshkhaliensis sp. nov., a novel actinomycete isolated from mangrove rhizosphere soil of Maheshkhali, Bangladesh.	Ara I, Matsumoto A, Abdul Bakir M, Kudo T, Omura S, Takahashi Y.	J Gen Appl Microbiol	10.2323/jgam.54.335	2008
Phylogeny	Majority of Actinomadura clinical isolates from sputa or bronchoalveolar lavage fluid in Japan belongs to the cluster of Actinomadura cremea and Actinomadura nitritigenes, and the description of Actinomadura chibensis sp. nov.	Hanafy A, Ito J, Iida S, Kang Y, Kogure T, Yazawa K, Yaguchi T, Mikami Y.	Mycopathologia	10.1007/s11046-006-0045-6	2006
Phylogeny	Actinomadura rubteroloni sp. nov. and Actinomadura macrotermitis sp. nov., isolated from the gut of the fungus growing-termite Macrotermes natalensis.	Benndorf R, Martin K, Kufner M, de Beer ZW, Vollmers J, Kaster AK, Beemelmanns C.	Int J Syst Evol Microbiol	10.1099/ijsem.0.004403	2020
Enzymology	Actinomadura fibrosa sp. nov. isolated from soil.	Mertz FP, Yao RC.	Int J Syst Bacteriol	10.1099/00207713-40-1-28	1990
Phylogeny	Nocardia mexicana sp. nov., a new pathogen isolated from human mycetomas.	Rodriguez-Nava V, Couble A, Molinard C, Sandoval H, Boiron P, Laurent F.	J Clin Microbiol	10.1128/jcm.42.10.4530-4535.2004	2004
Phylogeny	Actinomadura darangshiensis sp. nov., isolated from a volcanic cone.	Lee SD, Kim SB	Int J Syst Evol Microbiol	10.1099/ijs.0.000099	2015

References

#10730	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 43067
#19936	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the JMRC: Jena Microbial Resource Collection (JMRC):
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#39304	; Curators of the CIP;
#51271	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 32944
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68368	Automatically annotated from API 20E .
#68371	Automatically annotated from API 50CH acid .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120745	Collection of Institut Pasteur ; Curators of the CIP; CIP 105487
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Actinomadura madurae (DSM 43067, ATCC 19425, CCM 136)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Multicellular morphology

Culture and growth conditions

Culture medium

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Physiology and metabolism

Oxygen tolerance

Spore formation

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Halophily

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Antibiotic resistance

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Metabolite tests

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Fatty acid profile

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Genome browser: GCA_047130825

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