Streptomyces lincolnensis (DSM 40355, ATCC 25466, CBS 630.70)

Cell morphology

Multimedia

• @ref:	9478
  multimedia content:	DSM_40355.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40355.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	9478
  multimedia content:	DSM_40355.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40355.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	Leibniz-Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9478	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9478	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Metabolite production

@ref	Chebi-ID	Metabolite	Production
67770	6472 ChEBI	lincomycin

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	ppGpp biosynthesis	100	4 of 4
66794	CMP-KDO biosynthesis	100	4 of 4
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	cardiolipin biosynthesis	100	7 of 7
66794	methylglyoxal degradation	100	5 of 5
66794	adipate degradation	100	2 of 2
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	grixazone biosynthesis	100	2 of 2
66794	myo-inositol biosynthesis	100	10 of 10
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	pentose phosphate pathway	100	11 of 11
66794	glycogen metabolism	100	5 of 5
66794	threonine metabolism	100	10 of 10
66794	ethanol fermentation	100	2 of 2
66794	butanoate fermentation	100	4 of 4
66794	resorcinol degradation	100	2 of 2
66794	valine metabolism	100	9 of 9
66794	glycogen biosynthesis	100	4 of 4
66794	palmitate biosynthesis	100	22 of 22
66794	acetate fermentation	100	4 of 4
66794	IAA biosynthesis	100	3 of 3
66794	enterobactin biosynthesis	100	3 of 3
66794	starch degradation	100	10 of 10
66794	aspartate and asparagine metabolism	100	9 of 9
66794	biotin biosynthesis	100	4 of 4
66794	chorismate metabolism	100	9 of 9
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	ribulose monophosphate pathway	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	aerobactin biosynthesis	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	cellulose degradation	100	5 of 5
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	coenzyme A metabolism	100	4 of 4
66794	photosynthesis	92.86	13 of 14
66794	heme metabolism	92.86	13 of 14
66794	leucine metabolism	92.31	12 of 13
66794	phenylalanine metabolism	92.31	12 of 13
66794	degradation of aromatic, nitrogen containing compounds	91.67	11 of 12
66794	proline metabolism	90.91	10 of 11
66794	Entner Doudoroff pathway	90	9 of 10
66794	serine metabolism	88.89	8 of 9
66794	NAD metabolism	88.89	16 of 18
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	4-hydroxymandelate degradation	88.89	8 of 9
66794	dTDPLrhamnose biosynthesis	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	ketogluconate metabolism	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	flavin biosynthesis	86.67	13 of 15
66794	alanine metabolism	86.21	25 of 29
66794	purine metabolism	86.17	81 of 94
66794	tetrahydrofolate metabolism	85.71	12 of 14
66794	glutamate and glutamine metabolism	85.71	24 of 28
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	propanol degradation	85.71	6 of 7
66794	citric acid cycle	85.71	12 of 14
66794	vitamin B12 metabolism	85.29	29 of 34
66794	methionine metabolism	84.62	22 of 26
66794	lipid metabolism	83.87	26 of 31
66794	arginine metabolism	83.33	20 of 24
66794	metabolism of disaccharids	81.82	9 of 11
66794	tryptophan metabolism	81.58	31 of 38
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	3-chlorocatechol degradation	80	4 of 5
66794	metabolism of amino sugars and derivatives	80	4 of 5
66794	4-hydroxyphenylacetate degradation	80	8 of 10
66794	degradation of sugar acids	80	20 of 25
66794	propionate fermentation	80	8 of 10
66794	gallate degradation	80	4 of 5
66794	pyrimidine metabolism	80	36 of 45
66794	degradation of pentoses	78.57	22 of 28
66794	degradation of hexoses	77.78	14 of 18
66794	d-mannose degradation	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	oxidative phosphorylation	76.92	70 of 91
66794	urea cycle	76.92	10 of 13
66794	vitamin B1 metabolism	76.92	10 of 13
66794	glycolysis	76.47	13 of 17
66794	non-pathway related	76.32	29 of 38
66794	lysine metabolism	76.19	32 of 42
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	phenol degradation	75	15 of 20
66794	sulfopterin metabolism	75	3 of 4
66794	cyclohexanol degradation	75	3 of 4
66794	isoprenoid biosynthesis	73.08	19 of 26
66794	d-xylose degradation	72.73	8 of 11
66794	cholesterol biosynthesis	72.73	8 of 11
66794	histidine metabolism	72.41	21 of 29
66794	aclacinomycin biosynthesis	71.43	5 of 7
66794	glutathione metabolism	71.43	10 of 14
66794	polyamine pathway	69.57	16 of 23
66794	degradation of sugar alcohols	68.75	11 of 16
66794	acetoin degradation	66.67	2 of 3
66794	cysteine metabolism	66.67	12 of 18
66794	3-phenylpropionate degradation	66.67	10 of 15
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	tyrosine metabolism	64.29	9 of 14
66794	androgen and estrogen metabolism	62.5	10 of 16
66794	phenylpropanoid biosynthesis	61.54	8 of 13
66794	phosphatidylethanolamine bioynthesis	61.54	8 of 13
66794	sulfate reduction	61.54	8 of 13
66794	chlorophyll metabolism	61.11	11 of 18
66794	arachidonate biosynthesis	60	3 of 5
66794	glycine metabolism	60	6 of 10
66794	coenzyme M biosynthesis	60	6 of 10
66794	lipoate biosynthesis	60	3 of 5
66794	daunorubicin biosynthesis	55.56	5 of 9
66794	nitrate assimilation	55.56	5 of 9
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	ascorbate metabolism	50	11 of 22
66794	carnitine metabolism	50	4 of 8
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	phenylmercury acetate degradation	50	1 of 2
66794	toluene degradation	50	2 of 4
66794	alginate biosynthesis	50	2 of 4
66794	kanosamine biosynthesis II	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	quinate degradation	50	1 of 2
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	carotenoid biosynthesis	45.45	10 of 22
66794	arachidonic acid metabolism	44.44	8 of 18
66794	lipid A biosynthesis	44.44	4 of 9
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	hydrogen production	40	2 of 5
66794	elloramycin biosynthesis	40	2 of 5
66794	bacilysin biosynthesis	40	2 of 5
66794	D-cycloserine biosynthesis	40	2 of 5
66794	vitamin K metabolism	40	2 of 5
66794	vitamin B6 metabolism	36.36	4 of 11
66794	methane metabolism	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	mevalonate metabolism	28.57	2 of 7
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	methanogenesis from CO2	25	3 of 12
66794	lactate fermentation	25	1 of 4

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM168535v1 assembly for Streptomyces lincolnensis NRRL 2936	complete	GCA_001685355	1915.4	2872777253	1915	99.46
66792	Streptomyces lincolnensis ATCC 25466	complete			2563366702	1915	74.76

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces lincolnensis gene for 16S ribosomal RNA, partial sequence, strain: JCM 4488	D44182	120		1915
20218	Streptomyces lincolnensis gene for 16S rRNA, partial sequence, strain: NBRC 13054	AB184279	1471		1915
20218	Streptomyces lincolnensis 16S rRNA gene, strain NRRL2936	X79854	1519		1915

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Studies of lincosamide formation complete the biosynthetic pathway for lincomycin A.	Wang SA, Lin CI, Zhang J, Ushimaru R, Sasaki E, Liu HW.	Proc Natl Acad Sci U S A	10.1073/pnas.2009306117	2020
Metabolism	Beyond Self-Resistance: ABCF ATPase LmrC Is a Signal-Transducing Component of an Antibiotic-Driven Signaling Cascade Accelerating the Onset of Lincomycin Biosynthesis.	Koberska M, Vesela L, Vimberg V, Lenart J, Vesela J, Kamenik Z, Janata J, Balikova Novotna G.	mBio	10.1128/mbio.01731-21	2021
	Molecular basis for the diversification of lincosamide biosynthesis by pyridoxal phosphate-dependent enzymes.	Mori T, Moriwaki Y, Sakurada K, Lyu S, Kadlcik S, Janata J, Mazumdar A, Koberska M, Terada T, Kamenik Z, Abe I.	Nat Chem	10.1038/s41557-024-01687-7	2025
Metabolism	In vitro characterization of LmbK and LmbO: identification of GDP-D-erythro-alpha-D-gluco-octose as a key intermediate in lincomycin A biosynthesis.	Lin CI, Sasaki E, Zhong A, Liu HW.	J Am Chem Soc	10.1021/ja412194w	2014
Metabolism	New Concept of the Biosynthesis of 4-Alkyl-L-Proline Precursors of Lincomycin, Hormaomycin, and Pyrrolobenzodiazepines: Could a gamma-Glutamyltransferase Cleave the C-C Bond?	Jiraskova P, Gazak R, Kamenik Z, Steiningerova L, Najmanova L, Kadlcik S, Novotna J, Kuzma M, Janata J.	Front Microbiol	10.3389/fmicb.2016.00276	2016
Enzymology	Adaptation of an L-proline adenylation domain to use 4-propyl-L-proline in the evolution of lincosamide biosynthesis.	Kadlcik S, Kucera T, Chalupska D, Gazak R, Koberska M, Ulanova D, Kopecky J, Kutejova E, Najmanova L, Janata J.	PLoS One	10.1371/journal.pone.0084902	2013
Metabolism	Lincosamide synthetase--a unique condensation system combining elements of nonribosomal peptide synthetase and mycothiol metabolism.	Janata J, Kadlcik S, Koberska M, Ulanova D, Kamenik Z, Novak P, Kopecky J, Novotna J, Radojevic B, Plhackova K, Gazak R, Najmanova L.	PLoS One	10.1371/journal.pone.0118850	2015
Metabolism	Site and substrate specificity of the ermC 23S rRNA methyltransferase.	Denoya CD, Dubnau D.	J Bacteriol	10.1128/jb.169.8.3857-3860.1987	1987
	The biosynthesis of nitrogen-, sulfur-, and high-carbon chain-containing sugars.	Lin CI, McCarty RM, Liu HW.	Chem Soc Rev	10.1039/c2cs35438a	2013
Metabolism	N-demethylation of nicotine and reduction of nicotine-1'-N-oxide by Microsporum gypseum.	Sindelar RD, Rosazza JP, Barfknecht CF.	Appl Environ Microbiol	10.1128/aem.38.5.836-839.1979	1979
Metabolism	Optimization and characterization of bioactive secondary metabolites from Streptomyces sp CMSTAAHL-4 isolated from mangrove sediment.	Nisha SJ, Uma G, Sathishkumar R, Prakash VSG, Isaac R, Citarasu T.	BMC Microbiol	10.1186/s12866-025-03763-5	2025
	DeoR regulates lincomycin production in Streptomyces lincolnensis	Zou J, Mao Y, Hou B, Kang Y, Wang R, Wu H, Ye J, Zhang H.	World J Microbiol Biotechnol.		2023
	DeoR regulates lincomycin production in Streptomyces lincolnensis.	Zou J, Mao Y, Hou B, Kang Y, Wang R, Wu H, Ye J, Zhang H.	World J Microbiol Biotechnol	10.1007/s11274-023-03788-w	2023
	Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis.	Mao Y, Zhang X, Zhou T, Hou B, Ye J, Wu H, Wang R, Zhang H.	Microb Cell Fact	10.1186/s12934-023-02284-y	2024
	PAS domain containing regulator SLCG_7083 involved in morphological development and glucose utilization in Streptomyces lincolnensis.	Lin CY, Ru Y, Jin Y, Lin Q, Zhao GR.	Microb Cell Fact	10.1186/s12934-023-02263-3	2023
	Draft Genome Sequence of Streptomyces sp. Strain NL15-2K, a Degrader of Lignin-Derived Aromatic Compounds, Isolated from Forest Soil.	Nishimura M, Kawakami S, Otsuka H.	Microbiol Resour Announc	10.1128/mra.01456-18	2019
	Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor.	Lu T, Wu X, Cao Q, Xia Y, Xun L, Liu H.	mBio	10.1128/mbio.03862-21	2022
	Comparative transcriptomic analysis reveals the significant pleiotropic regulatory effects of LmbU on lincomycin biosynthesis.	Lin CY, Pang AP, Zhang Y, Qiao J, Zhao GR.	Microb Cell Fact	10.1186/s12934-020-01298-0	2020
Phylogeny	A phylogenetic and evolutionary analysis of antimycin biosynthesis.	Joynt R, Seipke RF.	Microbiology (Reading)	10.1099/mic.0.000572	2018
	23S ribosomal ribonucleic acid of macrolide-producing streptomycetes contains methylated adenine.	Graham MY, Weisblum B.	J Bacteriol	10.1128/jb.137.3.1464-1467.1979	1979
	Cloning of a lincosamide resistance determinant from Streptomyces caelestis, the producer of celesticetin, and characterization of the resistance mechanism.	Calcutt MJ, Cundliffe E.	J Bacteriol	10.1128/jb.172.8.4710-4714.1990	1990
Metabolism	The protocatechuic acid catabolism regulator PcaV inhibits lincomycin biosynthesis either directly or indirectly through the control of the expression of other regulatory or metabolic genes.	Zhou T, Wang R, Jiang W, Zhao J, Ye J, Wu H, Zhang H.	Int J Biol Macromol	10.1016/j.ijbiomac.2025.143649	2025
	MarR family regulator LcbR2 activates lincomycin biosynthesis in multiple ways.	Wang R, Chen L, Zhao J, Gao Y, Zhou T, Ye J, Wu H, Zhang H.	Int J Biol Macromol	10.1016/j.ijbiomac.2025.140292	2025
	LcbR1, a newly identified GntR family regulator, represses lincomycin biosynthesis in Streptomyces lincolnensis.	Wang R, Zhao J, Chen L, Ye J, Wu H, Zhang H.	Appl Microbiol Biotechnol	10.1007/s00253-023-12756-1	2023
	Characterization of a TetR-type positive regulator AtrA for lincomycin production in Streptomyces lincolnensis.	Wu W, Kang Y, Hou B, Ye J, Wang R, Wu H, Zhang H.	Biosci Biotechnol Biochem	10.1093/bbb/zbad046	2023
	Discovery and characterization of l-DOPA 2,3-dioxygenase from Streptomyces hygroscopicus jingganensis.	Ringenbach S, Yoza R, Jones PA, Du M, Klugh KL, Peterson LW, Colabroy KL.	Arch Biochem Biophys	10.1016/j.abb.2024.109967	2024
	New targets of TetR-type regulator SLCG_2919 for controlling lincomycin biosynthesis in Streptomyces lincolnensis.	Xu Y, Yi J, Kai Y, Li B, Liu M, Zhou Q, Wang J, Wang J, Liu R, Wu H.	J Basic Microbiol	10.1002/jobm.202300203	2024
Metabolism	AflQ1-Q2 represses lincomycin biosynthesis via multiple cascades in Streptomyces lincolnensis.	Wang R, Zhou T, Kong F, Hou B, Ye J, Wu H, Zhang H.	Appl Microbiol Biotechnol	10.1007/s00253-023-12429-z	2023
	AdpAlin regulates lincomycin and melanin biosynthesis by modulating precursors flux in Streptomyces lincolnensis.	Kang Y, Wu W, Zhang F, Chen L, Wang R, Ye J, Wu H, Zhang H.	J Basic Microbiol	10.1002/jobm.202200692	2023
	Simultaneous improvement of lincomycin A production and reduction of lincomycin B levels in Streptomyces lincolnensis using a combined medium optimization approach	Zheng Xh, Ye Rf, Ding Qh, Hu Fx, Zhang Hz, Lai S.	Ann Microbiol		2022
	TetR family regulator AbrT controls lincomycin production and morphological development in Streptomyces lincolnensis.	Xu Y, Liu M, Zhao R, Pan Y, Wu P, Zhang C, Chi X, Zhang B, Wu H.	Microb Cell Fact	10.1186/s12934-024-02498-8	2024
Metabolism	A putative redox-sensing regulator Rex regulates lincomycin biosynthesis in Streptomyces lincolnensis.	Hou B, Wang R, Zou J, Zhang F, Wu H, Ye J, Zhang H.	J Basic Microbiol	10.1002/jobm.202100249	2021
Transcriptome	Effects of the pleiotropic regulator DasR on lincomycin production in Streptomyces lincolnensis.	Pai H, Liu Y, Zhang C, Su J, Lu W.	Appl Microbiol Biotechnol	10.1007/s00253-024-13201-7	2024
	Lincolnenins A-D: Isomeric Bactericidal Bianthracenes from Streptomyces lincolnensis.	Mohamed OG, Khalil ZG, Salim AA, Cui H, Blumenthal A, Capon RJ.	J Org Chem	10.1021/acs.joc.0c02492	2021
Genetics	Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization.	Zhao X, Lu H, Peng S, Hang H, Aldahmash W, Al-Ghadi MQ, Tang W, Pei J, Xun W, Guo M, Mohsin A.	Front Microbiol	10.3389/fmicb.2025.1561042	2025
Metabolism	Amplification of lmbB1 gene in Streptomyces lincolnensis improves quantity and quality of lincomycin A fermentation.	Yang J, Ye R, Zhang H, Liu Y.	Prep Biochem Biotechnol	10.1080/10826068.2019.1710714	2020
	Transcriptional regulation of a leucine-responsive regulatory protein for directly controlling lincomycin biosynthesis in Streptomyces lincolnensis.	Xu Y, Tang Y, Wang N, Liu J, Cai X, Cai H, Li J, Tan G, Liu R, Bai L, Zhang L, Wu H, Zhang B.	Appl Microbiol Biotechnol	10.1007/s00253-020-10381-w	2020
	The response regulator CrsR positively regulates ansamitocin P-3 biosynthesis in Actinosynnema pretiosum.	Zhang P, Zong G, Wang T, Zhao S, Sun R, Fu J, Liu M, Cao G.	Front Microbiol	10.3389/fmicb.2025.1684526	2025
Metabolism	Developmental regulator BldD directly regulates lincomycin biosynthesis in Streptomyces lincolnensis.	Li J, Wang N, Tang Y, Cai X, Xu Y, Liu R, Wu H, Zhang B.	Biochem Biophys Res Commun	10.1016/j.bbrc.2019.08.079	2019
	Coupled strategy based on regulator manipulation and medium optimization empowers the biosynthetic overproduction of lincomycin.	Cai X, Xu W, Zheng Y, Wu S, Zhao R, Wang N, Tang Y, Ke M, Kang Q, Bai L, Zhang B, Wu H.	Synth Syst Biotechnol	10.1016/j.synbio.2024.01.004	2024
	Erratum for Hou et al., "The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis".	Hou B, Lin Y, Wu H, Guo M, Petkovic H, Tao L, Zhu X, Ye J, Zhang H.	J Bacteriol	10.1128/jb.00777-17	2018
Metabolism	A New Way of Belonging: Active-Site Investigation of L-DOPA Dioxygenase, a VOC Family Enzyme from Lincomycin Biosynthesis.	Colabroy KL, Horwitz AD, Basciano VR, Fu Y, Travitz KM, Robinson MK, Shimanski BA, Hoffmann TW.	Biochemistry	10.1021/acs.biochem.9b00456	2019
	ABCF protein-mediated resistance shapes bacterial responses to antibiotics based on their type and concentration.	Koberska M, Vesela L, Novotna M, Mahor D, Mazumdar A, Pindakova N, Omena Petravicius P, Pokorna J, Kamenik Z, Balikova Novotna G.	mBio	10.1128/mbio.01568-25	2025
Metabolism	Global regulator BldA regulates morphological differentiation and lincomycin production in Streptomyces lincolnensis.	Hou B, Tao L, Zhu X, Wu W, Guo M, Ye J, Wu H, Zhang H.	Appl Microbiol Biotechnol	10.1007/s00253-018-8900-1	2018
Metabolism	Isolation, Structure Elucidation, and Biosynthesis of a Cysteate-Containing Nonribosomal Peptide in Streptomyces lincolnensis.	Wang M, Chen D, Zhao Q, Liu W.	J Org Chem	10.1021/acs.joc.8b00044	2018
Metabolism	Enhanced lincomycin production by co-overexpression of metK1 and metK2 in Streptomyces lincolnensis.	Xu Y, Tan G, Ke M, Li J, Tang Y, Meng S, Niu J, Wang Y, Liu R, Wu H, Bai L, Zhang L, Zhang B.	J Ind Microbiol Biotechnol	10.1007/s10295-018-2029-1	2018
	Antibacterial activity of soil-isolated Bacillus altitudinis/pumilus complex against methicillin-resistant Staphylococcus aureus from Mwanza, Tanzania.	Abednego RN, Silago V.	Afr J Lab Med	10.4102/ajlm.v12i1.2167	2023
	Analysis of the effect of pulsed light on the protein of Lactobacillus plantarum based on liquid mass spectrometry.	Ge S, Zhang B.	Food Sci Biotechnol	10.1007/s10068-023-01365-3	2024
	A Lincomycin-Specific Antibody Was Developed Using Hapten Prediction, and an Immunoassay Was Established to Detect Lincomycin in Pork and Milk.	Shang Y, Zhang D, Shen Y, Pan Y, Wang J, Wang Y.	Foods	10.3390/foods13193118	2024
	Therapeutic effects of lincomycin and level of drug degradation in broiler tissues after treatment.	Wijayanti AD, Muzaki AY, Wibisono C, Widiasih DA.	Vet World	10.14202/vetworld.2024.1026-1034	2024
	Progress in the Stereoselective Synthesis Methods of Pyrrolidine-Containing Drugs and Their Precursors.	Smolobochkin A, Gazizov A, Appazov N, Sinyashin O, Burilov A.	Int J Mol Sci	10.3390/ijms252011158	2024
Metabolism	Co-overexpression of lmbW and metK led to increased lincomycin A production and decreased byproduct lincomycin B content in an industrial strain of Streptomyces lincolnensis.	Pang AP, Du L, Lin CY, Qiao J, Zhao GR.	J Appl Microbiol	10.1111/jam.12919	2015
Metabolism	Improvement of lincomycin production by mutant selection and metabolic regulation.	Pang X, Zheng Y, Qiao X, Mao Q, Ma Q, Ye R.	Prep Biochem Biotechnol	10.1080/10826068.2016.1207083	2017
	Oral bioavailability and egg drug residue of lincomycin in laying hens after different treatment.	Kim JH, Ko JW, Kim JW, Jeong JS, Kim CY, Shin IS, Kim TW.	Poult Sci	10.1016/j.psj.2023.103147	2024
Enzymology	Defining a kinetic mechanism for l-DOPA 2,3 dioxygenase, a single-domain type I extradiol dioxygenase from Streptomyces lincolnensis.	Colabroy KL, Smith IR, Vlahos AH, Markham AJ, Jakubik ME.	Biochim Biophys Acta	10.1016/j.bbapap.2013.12.005	2014
Metabolism	Histidine residues at the copper-binding site in human tyrosinase are essential for its catalytic activities.	Noh H, Lee SJ, Jo HJ, Choi HW, Hong S, Kong KH.	J Enzyme Inhib Med Chem	10.1080/14756366.2020.1740691	2020
	Gordonia species as a rare pathogen isolated from milk of dairy cows with mastitis.	Bzdil J, Slosarkova S, Fleischer P, Matiasovic J.	Sci Rep	10.1038/s41598-022-09340-4	2022
	New Kid on the Block: LmbU Expands the Repertoire of Specialized Metabolic Regulators in Streptomyces.	Ju KS, Zhang X, Elliot MA.	J Bacteriol	10.1128/jb.00559-17	2018
	TetR-Type Regulator SLCG_2919 Is a Negative Regulator of Lincomycin Biosynthesis in Streptomyces lincolnensis.	Xu Y, Ke M, Li J, Tang Y, Wang N, Tan G, Wang Y, Liu R, Bai L, Zhang L, Wu H, Zhang B.	Appl Environ Microbiol	10.1128/aem.02091-18	2019
Metabolism	Effects of flow field on the metabolic characteristics of Streptomyces lincolnensis in the industrial fermentation of lincomycin.	Li X, Zhang J, Tan YL, Li ZH, Yu XF, Xia JY, Chu J, Ge YQ.	J Biosci Bioeng	10.1016/j.jbiosc.2012.07.015	2013
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	Synthetic oxepanoprolinamide iboxamycin is active against Listeria monocytogenes despite the intrinsic resistance mediated by VgaL/Lmo0919 ABCF ATPase.	Brodiazhenko T, Turnbull KJ, Wu KJY, Takada H, Tresco BIC, Tenson T, Myers AG, Hauryliuk V.	JAC Antimicrob Resist	10.1093/jacamr/dlac061	2022
Genetics	Genomic and Phenotypic Characterization of Mastitis-Causing Staphylococci and Probiotic Lactic Acid Bacteria Isolated from Raw Sheep's Milk.	Apostolakos I, Skarlatoudi T, Vatavali K, Giannouli A, Bosnea L, Mataragas M.	Int J Mol Sci	10.3390/ijms241813883	2023
	Isolation, Characterization of Pyraclostrobin Derived from Soil Actinomycete Streptomyces sp. HSN-01 and Its Antimicrobial and Anticancer Activity.	Math HH, Nayaka S, Rudrappa M, Kumar RS, Almansour AI, Perumal K, Kantli GB.	Antibiotics (Basel)	10.3390/antibiotics12071211	2023
Genetics	Comparative Genomic Analysis Reveals the Functional Traits and Safety Status of Lactic Acid Bacteria Retrieved from Artisanal Cheeses and Raw Sheep Milk.	Apostolakos I, Paramithiotis S, Mataragas M.	Foods	10.3390/foods12030599	2023
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	Observing extradiol dioxygenases in action through a crystalline lens.	Campbell J, Wang Y.	Methods Enzymol	10.1016/bs.mie.2024.05.020	2024
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	The leucine-responsive regulatory protein SCAB_Lrp modulates thaxtomin biosynthesis, pathogenicity, and morphological development in Streptomyces scabies.	Liu J, Wang Y, He H, Dong S, Tang L, Yang E, Wang W, Zhang B.	Mol Plant Pathol	10.1111/mpp.13285	2023
	Identification and Biosynthesis of Pro-Inflammatory Sulfonolipids from an Opportunistic Pathogen Chryseobacterium gleum.	Hou L, Tian HY, Wang L, Ferris ZE, Wang J, Cai M, Older EA, Raja MRK, Xue D, Sun W, Nagarkatti P, Nagarkatti M, Chen H, Fan D, Tang X, Li J.	ACS Chem Biol	10.1021/acschembio.2c00141	2022
	Enhancing the Antibiotic Production by Thermophilic Bacteria Isolated from Hot Spring Waters via Ethyl Methanesulfonate Mutagenesis.	Kortam YG, Abd El-Rahim WM, Khattab AEA, Rebouh NY, Gurina RR, Barakat OS, Zakaria M, Moawad H.	Antibiotics (Basel)	10.3390/antibiotics12071095	2023
	Combined Anti-Bacterial Actions of Lincomycin and Freshly Prepared Silver Nanoparticles: Overcoming the Resistance to Antibiotics and Enhancement of the Bioactivity.	Abdul-Jabbar AM, Hussian NN, Mohammed HA, Aljarbou A, Akhtar N, Khan RA.	Antibiotics (Basel)	10.3390/antibiotics11121791	2022
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	Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases.	Leferink NGH, Escorcia AM, Ouwersloot BR, Johanissen LO, Hay S, van der Kamp MW, Scrutton NS.	Chembiochem	10.1002/cbic.202100688	2022
Enzymology	Biochemical characterization of L-DOPA 2,3-dioxygenase, a single-domain type I extradiol dioxygenase from lincomycin biosynthesis.	Colabroy KL, Hackett WT, Markham AJ, Rosenberg J, Cohen DE, Jacobson A.	Arch Biochem Biophys	10.1016/j.abb.2008.08.022	2008
Pathogenicity	Impact of buffered sodium butyrate as a partial or total dietary alternative to lincomycin on performance, IGF-1 and TLR4 genes expression, serum indices, intestinal histomorphometry, Clostridia, and litter hygiene of broiler chickens.	Bawish BM, Zahran MFS, Ismael E, Kamel S, Ahmed YH, Hamza D, Attia T, Fahmy KNE.	Acta Vet Scand	10.1186/s13028-023-00704-y	2023
	A Comparative Study of Approaches to Improve the Sensitivity of Lateral Flow Immunoassay of the Antibiotic Lincomycin.	Serebrennikova KV, Hendrickson OD, Zvereva EA, Popravko DS, Zherdev AV, Xu C, Dzantiev BB.	Biosensors (Basel)	10.3390/bios10120198	2020
Metabolism	LmbJ and LmbIH protein levels correlate with lincomycin production in Streptomyces lincolnensis.	Hola K, Janata J, Kopecky J, Spizek J.	Lett Appl Microbiol	10.1046/j.1472-765x.2003.01432.x	2003
Metabolism	High-throughput quantification of lincomycin traces in fermentation broth of genetically modified Streptomyces spp. Comparison of ultra-performance liquid chromatography and high-performance liquid chromatography with UV detection.	Olsovska J, Jelinkova M, Man P, Koberska M, Janata J, Flieger M.	J Chromatogr A	10.1016/j.chroma.2006.11.017	2007
	Biosynthesis of ansamitocin P-3 incurs stress on the producing strain Actinosynnema pretiosum at multiple targets.	Huang Q, Zhang X, Guo Z, Fu X, Zhao Y, Kang Q, Bai L.	Commun Biol	10.1038/s42003-023-05227-w	2023
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	Gut bacterial species in late trimester of pregnant sows influence the occurrence of stillborn piglet through pro-inflammation response.	Chen Z, Yang H, Fu H, Wu L, Liu M, Jiang H, Liu Q, Wang Y, Xiong S, Zhou M, Sun X, Chen C, Huang L.	Front Immunol	10.3389/fimmu.2022.1101130	2022
	Implementation and Validation of an Analytical Method for Lincomycin Determination in Feathers and Edible Tissues of Broiler Chickens by Liquid Chromatography Tandem Mass Spectrometry.	Maddaleno A, Pokrant E, Yanten F, San Martin B, Cornejo J.	J Anal Methods Chem	10.1155/2019/4569707	2019
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	WD-repeat protein encoding genes among prokaryotes of the Streptomyces genus.	Stoytcheva Z, Joshi B, Spizek J, Tichy P.	Folia Microbiol (Praha)	10.1007/bf02817613	2000
	[Establishment of transformation system of Streptomyces lincolnensis].	Zhang H, Yao F, Ye J.	Wei Sheng Wu Xue Bao		1999
	Biocatalytic Carbon-Hydrogen and Carbon-Fluorine Bond Cleavage through Hydroxylation Promoted by a Histidyl-Ligated Heme Enzyme.	Wang Y, Davis I, Shin I, Wherritt DJ, Griffith WP, Dornevil K, Colabroy KL, Liu A.	ACS Catal	10.1021/acscatal.9b00231	2019
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	Antimicrobial and enzymatic activity of actinomycetes isolated from soils of coastal islands.	Charousova I, Medo J, Halenarova E, Javorekova S.	J Adv Pharm Technol Res	10.4103/japtr.japtr_161_16	2017
	Purification and properties of glutamate synthase from Streptomyces lincolnensis.	Jin Z, Jiao R.	Sci China C Life Sci	10.1007/bf02882704	1998
Metabolism	Integrative transcriptome and proteome revealed high-yielding mechanisms of epsilon-poly-L-lysine by Streptomyces albulus.	Wang L, Yang H, Wu M, Zhang J, Zhang H, Mao Z, Chen X.	Front Microbiol	10.3389/fmicb.2023.1123050	2023
Enzymology	The genes lmbB1 and lmbB2 of Streptomyces lincolnensis encode enzymes involved in the conversion of L-tyrosine to propylproline during the biosynthesis of the antibiotic lincomycin A.	Neusser D, Schmidt H, Spizek J, Novotna J, Peschke U, Kaschabeck S, Tichy P, Piepersberg W.	Arch Microbiol	10.1007/s002030050578	1998
	[Cloning and characterization of melanin biosynthesis genes from Streptomyces lincolnensis 78-11].	Zhang H, Yao F, Sun L.	Wei Sheng Wu Xue Bao		1998
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Genetics	Health-Promoting Nature of Lactococcus lactis IBB109 and Lactococcus lactis IBB417 Strains Exhibiting Proliferation Inhibition and Stimulation of Interleukin-18 Expression in Colorectal Cancer Cells.	Salanski P, Kowalczyk M, Bardowski JK, Szczepankowska AK.	Front Microbiol	10.3389/fmicb.2022.822912	2022
	Genome-encoded ABCF factors implicated in intrinsic antibiotic resistance in Gram-positive bacteria: VmlR2, Ard1 and CplR.	Obana N, Takada H, Crowe-McAuliffe C, Iwamoto M, Egorov AA, Wu KJY, Chiba S, Murina V, Paternoga H, Tresco BIC, Nomura N, Myers AG, Atkinson GC, Wilson DN, Hauryliuk V.	Nucleic Acids Res	10.1093/nar/gkad193	2023
	A validated stability-indicating HPLC method for routine analysis of an injectable lincomycin and spectinomycin formulation.	Abualhasan MN, Batrawi N, Sutcliffe OB, Zaid AN.	Sci Pharm	10.3797/scipharm.1207-13	2012
Metabolism	Mycobacterium hassiacum recovers from nitrogen starvation with up-regulation of a novel glucosylglycerate hydrolase and depletion of the accumulated glucosylglycerate.	Alarico S, Costa M, Sousa MS, Maranha A, Lourenco EC, Faria TQ, Ventura MR, Empadinhas N.	Sci Rep	10.1038/srep06766	2014
Pathogenicity	Dissemination of antibiotic resistance genes from antibiotic producers to pathogens.	Jiang X, Ellabaan MMH, Charusanti P, Munck C, Blin K, Tong Y, Weber T, Sommer MOA, Lee SY.	Nat Commun	10.1038/ncomms15784	2017
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Metabolism	Transformation of Streptomyces lincolnensis protoplasts with plasmid vectors.	Jandova Z, Tichy P.	Folia Microbiol (Praha)	10.1007/bf02933144	1992
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	Scientific Rationale and Clinical Basis for Clindamycin Use in the Treatment of Dermatologic Disease.	Armillei MK, Lomakin IB, Del Rosso JQ, Grada A, Bunick CG.	Antibiotics (Basel)	10.3390/antibiotics13030270	2024
	Coenzyme F420-dependent N5,N10-methylenetetrahydromethanopterin reductase (Mer) from Methanobacterium thermoautotrophicum strain Marburg. Cloning, sequencing, transcriptional analysis, and functional expression in Escherichia coli of the mer gene.	Vaupel M, Thauer RK.	Eur J Biochem	10.1111/j.1432-1033.1995.0773d.x	1995
Metabolism	The biosynthetic pathway of the aminonucleoside antibiotic puromycin, as deduced from the molecular analysis of the pur cluster of Streptomyces alboniger.	Tercero JA, Espinosa JC, Lacalle RA, Jimenez A.	J Biol Chem	10.1074/jbc.271.3.1579	1996
Biotechnology	Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review.	De La Hoz-Romo MC, Diaz L, Villamil L.	Antibiotics (Basel)	10.3390/antibiotics11070965	2022
	From Worms to Drug Candidate: The Story of Odilorhabdins, a New Class of Antimicrobial Agents.	Racine E, Gualtieri M.	Front Microbiol	10.3389/fmicb.2019.02893	2019
Metabolism	Isolation and identification of 3-propylidene-delta 1-pyrroline-5-carboxylic acid, a biosynthetic precursor of lincomycin.	Kuo MS, Yurek DA, Coats JH, Chung ST, Li GP.	J Antibiot (Tokyo)	10.7164/antibiotics.45.1773	1992
Metabolism	Development of an intergeneric conjugal transfer system for xinaomycins-producing Streptomyces noursei Xinao-4.	Sun FH, Luo D, Shu D, Zhong J, Tan H.	Int J Mol Sci	10.3390/ijms150712217	2014
	Utilization of the protoplast fusion technique to explore directional altering lincomycin producing microorganism.	Xu J, Mi G, Tang X.	Chin J Biotechnol		1992
	Actinomycetes: A Never-Ending Source of Bioactive Compounds-An Overview on Antibiotics Production.	De Simeis D, Serra S.	Antibiotics (Basel)	10.3390/antibiotics10050483	2021
	Effects of phosphate, glucose, and ammonium on cell growth and lincomycin production by Streptomyces lincolnensis in chemically defined media.	Young MD, Kempe LL, Bader FG.	Biotechnol Bioeng	10.1002/bit.260270318	1985
Phylogeny	Phylogenetic relatedness determined between antibiotic resistance and 16S rRNA genes in actinobacteria.	Sagova-Mareckova M, Ulanova D, Sanderova P, Omelka M, Kamenik Z, Olsovska J, Kopecky J.	BMC Microbiol	10.1186/s12866-015-0416-6	2015
Metabolism	An Efficient Method To Generate Gene Deletion Mutants of the Rapamycin-Producing Bacterium Streptomyces iranensis HM 35.	Netzker T, Schroeckh V, Gregory MA, Flak M, Krespach MKC, Leadlay PF, Brakhage AA.	Appl Environ Microbiol	10.1128/aem.00371-16	2016
	Macrolides and associated antibiotics based on similar mechanism of action like lincosamides in malaria.	Gaillard T, Dormoi J, Madamet M, Pradines B.	Malar J	10.1186/s12936-016-1114-z	2016
	Isolation and identification of gamma-aminobutyric acid in Streptomyces lincolnensis.	Haak WJ, Reineke LM.	Antimicrob Agents Chemother	10.1128/aac.19.3.493	1981
Genetics	Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C.	Crnovcic I, Ruckert C, Semsary S, Lang M, Kalinowski J, Keller U.	Adv Appl Bioinform Chem	10.2147/aabc.s117707	2017
Enzymology	Ways to Improve Insights into Clindamycin Pharmacology and Pharmacokinetics Tailored to Practice.	Armengol Alvarez L, Van de Sijpe G, Desmet S, Metsemakers WJ, Spriet I, Allegaert K, Rozenski J.	Antibiotics (Basel)	10.3390/antibiotics11050701	2022
Metabolism	Rancinamycins, metabolites produced by Streptomyces lincolnensis in sulfur-depleted media.	Argoudelis AD, Pyke TR, Sprague RW.	J Antibiot (Tokyo)	10.7164/antibiotics.29.777	1976
	Production of ergothioneine by Methylobacterium species.	Alamgir KM, Masuda S, Fujitani Y, Fukuda F, Tani A.	Front Microbiol	10.3389/fmicb.2015.01185	2015
Metabolism	Formation of 3-methylthioacrylic acid from methionine by Streptomyces lincolnensis. Isolation of a peroxidase.	Surette R, Vining LC.	J Antibiot (Tokyo)	10.7164/antibiotics.29.646	1976
Genetics	In silico genomic insights into aspects of food safety and defense mechanisms of a potentially probiotic Lactobacillus pentosus MP-10 isolated from brines of naturally fermented Aloreña green table olives.	Abriouel H, Perez Montoro B, Casado Munoz MDC, Knapp CW, Galvez A, Benomar N.	PLoS One	10.1371/journal.pone.0176801	2017
	Sequence and structural evolution of the KsgA/Dim1 methyltransferase family.	O'Farrell HC, Xu Z, Culver GM, Rife JP.	BMC Res Notes	10.1186/1756-0500-1-108	2008
Pathogenicity	Shielding the Next Generation: Symbiotic Bacteria from a Reproductive Organ Protect Bobtail Squid Eggs from Fungal Fouling.	Kerwin AH, Gromek SM, Suria AM, Samples RM, Deoss DJ, O'Donnell K, Frasca S, Sutton DA, Wiederhold NP, Balunas MJ, Nyholm SV.	mBio	10.1128/mbio.02376-19	2019
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Metabolism	Identification of the S-transferase like superfamily bacillithiol transferases encoded by Bacillus subtilis.	Perera VR, Lapek JD, Newton GL, Gonzalez DJ, Pogliano K.	PLoS One	10.1371/journal.pone.0192977	2018
	Altered lipopolysaccharide characteristic of the I69 phenotype in Haemophilus influenzae results from mutations in a novel gene, isn.	Preston A, Maskell D, Johnson A, Moxon ER.	J Bacteriol	10.1128/jb.178.2.396-402.1996	1996
Metabolism	Structural and functional plasticity of antibiotic resistance nucleotidylyltransferases revealed by molecular characterization of lincosamide nucleotidylyltransferases lnu(A) and lnu(D).	Stogios PJ, Evdokimova E, Morar M, Koteva K, Wright GD, Courvalin P, Savchenko A.	J Mol Biol	10.1016/j.jmb.2015.04.008	2015
	Effect of elevated tropospheric ozone on the structure of bacterial communities inhabiting the rhizosphere of herbaceous plants native to Germany.	Dohrmann AB, Tebbe CC.	Appl Environ Microbiol	10.1128/aem.71.12.7750-7758.2005	2005
Metabolism	The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.	Keller U, Lang M, Crnovcic I, Pfennig F, Schauwecker F.	J Bacteriol	10.1128/jb.01526-09	2010
	The multidrug ABC transporter BmrC/BmrD of Bacillus subtilis is regulated via a ribosome-mediated transcriptional attenuation mechanism.	Reilman E, Mars RA, van Dijl JM, Denham EL.	Nucleic Acids Res	10.1093/nar/gku832	2014
Metabolism	Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity.	Richard-Greenblatt M, Bach H, Adamson J, Pena-Diaz S, Li W, Steyn AJ, Av-Gay Y.	J Biol Chem	10.1074/jbc.m115.648642	2015
	Screening of a Leptospira biflexa mutant library to identify genes involved in ethidium bromide tolerance.	Petrosova H, Picardeau M.	Appl Environ Microbiol	10.1128/aem.01619-14	2014
	Quantum mechanical studies of lincosamides.	Kulczycka-Mierzejewska K, Trylska J, Sadlej J.	J Mol Model	10.1007/s00894-011-1272-4	2012
Metabolism	SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.	Kirm B, Magdevska V, Tome M, Horvat M, Karnicar K, Petek M, Vidmar R, Baebler S, Jamnik P, Fujs S, Horvat J, Fonovic M, Turk B, Gruden K, Petkovic H, Kosec G.	Microb Cell Fact	10.1186/1475-2859-12-126	2013
Metabolism	Cinnamic acid, an autoinducer of its own biosynthesis, is processed via Hca enzymes in Photorhabdus luminescens.	Chalabaev S, Turlin E, Bay S, Ganneau C, Brito-Fravallo E, Charles JF, Danchin A, Biville F.	Appl Environ Microbiol	10.1128/aem.02589-07	2008
Metabolism	A new resistance gene, linB, conferring resistance to lincosamides by nucleotidylation in Enterococcus faecium HM1025.	Bozdogan B, Berrezouga L, Kuo MS, Yurek DA, Farley KA, Stockman BJ, Leclercq R.	Antimicrob Agents Chemother	10.1128/aac.43.4.925	1999
Pathogenicity	An Enterococcus faecalis ABC homologue (Lsa) is required for the resistance of this species to clindamycin and quinupristin-dalfopristin.	Singh KV, Weinstock GM, Murray BE.	Antimicrob Agents Chemother	10.1128/aac.46.6.1845-1850.2002	2002
Pathogenicity	Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.	Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA.	Antimicrob Agents Chemother	10.1128/aac.01545-05	2006
Pathogenicity	Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.	Buriankova K, Doucet-Populaire F, Dorson O, Gondran A, Ghnassia JC, Weiser J, Pernodet JL.	Antimicrob Agents Chemother	10.1128/aac.48.1.143-150.2004	2004
Pathogenicity	Mitomycin resistance in Streptomyces lavendulae includes a novel drug-binding-protein-dependent export system.	Sheldon PJ, Mao Y, He M, Sherman DH.	J Bacteriol	10.1128/jb.181.8.2507-2512.1999	1999
Metabolism	Function of coenzyme F420 in aerobic catabolism of 2,4, 6-trinitrophenol and 2,4-dinitrophenol by Nocardioides simplex FJ2-1A.	Ebert S, Rieger PG, Knackmuss HJ.	J Bacteriol	10.1128/jb.181.9.2669-2674.1999	1999
	The ybiT gene of Erwinia chrysanthemi codes for a putative ABC transporter and is involved in competitiveness against endophytic bacteria during infection.	Llama-Palacios A, Lopez-Solanilla E, Rodriguez-Palenzuela P.	Appl Environ Microbiol	10.1128/aem.68.4.1624-1630.2002	2002
Enzymology	Molecular analysis of the gene encoding F420-dependent glucose-6-phosphate dehydrogenase from Mycobacterium smegmatis.	Purwantini E, Daniels L.	J Bacteriol	10.1128/jb.180.8.2212-2219.1998	1998
Metabolism	Targeted mutagenesis of the Mycobacterium smegmatis mca gene, encoding a mycothiol-dependent detoxification protein.	Rawat M, Uppal M, Newton G, Steffek M, Fahey RC, Av-Gay Y.	J Bacteriol	10.1128/jb.186.18.6050-6058.2004	2004
Metabolism	The highly conserved TldD and TldE proteins of Escherichia coli are involved in microcin B17 processing and in CcdA degradation.	Allali N, Afif H, Couturier M, Van Melderen L.	J Bacteriol	10.1128/jb.184.12.3224-3231.2002	2002
Enzymology	Genetic localization and molecular characterization of two key genes (mitAB) required for biosynthesis of the antitumor antibiotic mitomycin C.	Mao Y, Varoglu M, Sherman DH.	J Bacteriol	10.1128/jb.181.7.2199-2208.1999	1999
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Metabolism	The Novel Transcriptional Regulator LmbU Promotes Lincomycin Biosynthesis through Regulating Expression of Its Target Genes in Streptomyces lincolnensis.	Hou B, Lin Y, Wu H, Guo M, Petkovic H, Tao L, Zhu X, Ye J, Zhang H	J Bacteriol	10.1128/JB.00447-17	2017
Metabolism	Enhancement of antibiotic productions by engineered nitrate utilization in actinomycetes.	Meng S, Wu H, Wang L, Zhang B, Bai L	Appl Microbiol Biotechnol	10.1007/s00253-017-8292-7	2017
Metabolism	A family of r-determinants in Streptomyces spp. that specifies inducible resistance to macrolide, lincosamide, and streptogramin type B antibiotics.	Fujisawa Y, Weisblum B	J Bacteriol	10.1128/jb.146.2.621-631.1981	1981
	Developmental regulator RamRsl controls both morphological development and lincomycin biosynthesis in Streptomyces lincolnensis.	Wang R, Cao Y, Kong F, Hou B, Zhao J, Kang Y, Ye J, Wu H, Zhang H	J Appl Microbiol	10.1111/jam.15568	2022
Biotechnology	Complete genome sequence of high-yield strain S. lincolnensis B48 and identification of crucial mutations contributing to lincomycin overproduction.	Wang R, Kong F, Wu H, Hou B, Kang Y, Cao Y, Duan S, Ye J, Zhang H	Synth Syst Biotechnol	10.1016/j.synbio.2020.03.001	2020
	AdpAlin, a Pleiotropic Transcriptional Regulator, Is Involved in the Cascade Regulation of Lincomycin Biosynthesis in Streptomyces lincolnensis.	Kang Y, Wang Y, Hou B, Wang R, Ye J, Zhu X, Wu H, Zhang H	Front Microbiol	10.3389/fmicb.2019.02428	2019
	LmbU, a Cluster-Situated Regulator for Lincomycin, Consists of a DNA-Binding Domain, an Auto-Inhibitory Domain, and Forms Homodimer.	Hou B, Zhu X, Kang Y, Wang R, Wu H, Ye J, Zhang H	Front Microbiol	10.3389/fmicb.2019.00989	2019
Metabolism	Lincomycin biosynthesis involves a tyrosine hydroxylating heme protein of an unusual enzyme family.	Novotna J, Olsovska J, Novak P, Mojzes P, Chaloupkova R, Kamenik Z, Spizek J, Kutejova E, Mareckova M, Tichy P, Damborsky J, Janata J	PLoS One	10.1371/journal.pone.0079974	2013
Metabolism	Mutasynthesis of lincomycin derivatives with activity against drug-resistant staphylococci.	Ulanova D, Novotna J, Smutna Y, Kamenik Z, Gazak R, Sulc M, Sedmera P, Kadlcik S, Plhackova K, Janata J	Antimicrob Agents Chemother	10.1128/AAC.00918-09	2009
	New carbasugars from Streptomyces lincolnensis.	Sedmera P, Halada P, Pospisil S	Magn Reson Chem	10.1002/mrc.2408	2009
Transcriptome	Sequence analysis and heterologous expression of the lincomycin biosynthetic cluster of the type strain Streptomyces lincolnensis ATCC 25466.	Koberska M, Kopecky J, Olsovska J, Jelinkova M, Ulanova D, Man P, Flieger M, Janata J	Folia Microbiol (Praha)	10.1007/s12223-008-0060-8	2008
Metabolism	Putative lmbI and lmbH genes form a single lmbIH ORF in Streptomyces lincolnensis type strain ATCC 25466.	Janata J, Najmanova L, Novotna J, Hola K, Felsberg J, Spizek J	Antonie Van Leeuwenhoek	10.1023/a:1012034421088	2001
Enzymology	Molecular characterization of the lincomycin-production gene cluster of Streptomyces lincolnensis 78-11.	Peschke U, Schmidt H, Zhang HZ, Piepersberg W	Mol Microbiol	10.1111/j.1365-2958.1995.tb02338.x	1995
Metabolism	Monophenol monooxygenase and lincomysin biosynthesis in Streptomyces lincolnensis.	Michalik J, Emilianowicz-Czerska W, Switalski L, Raczynska-Bojanowska K	Antimicrob Agents Chemother	10.1128/AAC.8.5.526	1975
Biotechnology	An alternative sigma factor sigma(L) (sl) regulates lincomycin production in Streptomyces lincolnensis.	Tu B, Mao Y, Wang R, Kang Y, Ye J, Zhang H, Wu H	J Basic Microbiol	10.1002/jobm.202200485	2022
Phylogeny	Streptomyces caeruleatus sp. nov., with dark blue diffusible pigment.	Zhu HH, Guo J, Yao Q, Yang SZ, Deng MR, Li TH	Int J Syst Evol Microbiol	10.1099/ijs.0.017392-0	2010
Phylogeny	Streptomyces montanus sp. nov., a novel actinomycete isolated from soil.	Jiang H, Han L, Li J, Yu M, Zhao J, Guo X, Xiang W, Wang X	Int J Syst Evol Microbiol	10.1099/ijsem.0.004160	2020
Phylogeny	Streptomyces shaanxiensis sp. nov., a blue pigment-producing streptomycete from sewage irrigation soil.	Lin YB, Wang XY, Fang H, Ma YN, Tang J, Tang M, Wei GH	Int J Syst Evol Microbiol	10.1099/ijs.0.029959-0	2011