Streptomyces clavuligerus (DSM 738, ATCC 27064, DSM 41253)

Cell morphology

Multimedia

• @ref:	381
  multimedia content:	DSM_738-1.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_738-1.jpg
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	381
  multimedia content:	DSM_738.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_738.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
381	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
381	BENNETT'S AGAR (DSMZ Medium 548)		Medium recipe at MediaDive	Name: BENNETT'S AGAR (DSMZ Medium 548) Composition: Agar 15.0 g/l Glucose 10.0 g/l N-Z amine 2.0 g/l Yeast extract 1.0 g/l Beef extract 1.0 g/l Distilled water
381	NUTRIENT AGAR (DSMZ Medium 1)		Medium recipe at MediaDive	Name: NUTRIENT AGAR (DSMZ Medium 1) Composition: Agar 15.0 g/l Peptone 5.0 g/l Meat extract 3.0 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Observation

Metabolite production

@ref	Chebi-ID	Metabolite	Production
67770	23066 ChEBI	cephalosporin
67770	487869 ChEBI	clavulanate
67770	18203 ChEBI	penicillin N

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	pentose phosphate pathway	100	11 of 11
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	glycogen metabolism	100	5 of 5
66794	biotin biosynthesis	100	4 of 4
66794	daunorubicin biosynthesis	100	9 of 9
66794	starch degradation	100	10 of 10
66794	ribulose monophosphate pathway	100	2 of 2
66794	kanosamine biosynthesis II	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	ethanol fermentation	100	2 of 2
66794	cardiolipin biosynthesis	100	7 of 7
66794	threonine metabolism	100	10 of 10
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	adipate degradation	100	2 of 2
66794	myo-inositol biosynthesis	100	10 of 10
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	acetate fermentation	100	4 of 4
66794	metabolism of amino sugars and derivatives	100	5 of 5
66794	suberin monomers biosynthesis	100	2 of 2
66794	aerobactin biosynthesis	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	aspartate and asparagine metabolism	100	9 of 9
66794	butanoate fermentation	100	4 of 4
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	valine metabolism	100	9 of 9
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	lipoate biosynthesis	100	5 of 5
66794	ceramide biosynthesis	100	1 of 1
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	ppGpp biosynthesis	100	4 of 4
66794	folate polyglutamylation	100	1 of 1
66794	citric acid cycle	92.86	13 of 14
66794	leucine metabolism	92.31	12 of 13
66794	phenylalanine metabolism	92.31	12 of 13
66794	vitamin B12 metabolism	91.18	31 of 34
66794	propionate fermentation	90	9 of 10
66794	serine metabolism	88.89	8 of 9
66794	4-hydroxymandelate degradation	88.89	8 of 9
66794	NAD metabolism	88.89	16 of 18
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	photosynthesis	85.71	12 of 14
66794	glutamate and glutamine metabolism	85.71	24 of 28
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	propanol degradation	85.71	6 of 7
66794	lipid metabolism	83.87	26 of 31
66794	glycolate and glyoxylate degradation	83.33	5 of 6
66794	arginine metabolism	83.33	20 of 24
66794	alanine metabolism	82.76	24 of 29
66794	glycolysis	82.35	14 of 17
66794	metabolism of disaccharids	81.82	9 of 11
66794	degradation of sugar alcohols	81.25	13 of 16
66794	isoprenoid biosynthesis	80.77	21 of 26
66794	methionine metabolism	80.77	21 of 26
66794	cellulose degradation	80	4 of 5
66794	Entner Doudoroff pathway	80	8 of 10
66794	flavin biosynthesis	80	12 of 15
66794	factor 420 biosynthesis	80	4 of 5
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	4-hydroxyphenylacetate degradation	80	8 of 10
66794	heme metabolism	78.57	11 of 14
66794	glutathione metabolism	78.57	11 of 14
66794	chorismate metabolism	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	d-mannose degradation	77.78	7 of 9
66794	purine metabolism	77.66	73 of 94
66794	urea cycle	76.92	10 of 13
66794	vitamin B1 metabolism	76.92	10 of 13
66794	histidine metabolism	75.86	22 of 29
66794	pyrimidine metabolism	75.56	34 of 45
66794	isoleucine metabolism	75	6 of 8
66794	sulfopterin metabolism	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	polyamine pathway	73.91	17 of 23
66794	tryptophan metabolism	73.68	28 of 38
66794	cholesterol biosynthesis	72.73	8 of 11
66794	proline metabolism	72.73	8 of 11
66794	cysteine metabolism	72.22	13 of 18
66794	degradation of sugar acids	72	18 of 25
66794	aclacinomycin biosynthesis	71.43	5 of 7
66794	tyrosine metabolism	71.43	10 of 14
66794	lysine metabolism	69.05	29 of 42
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
66794	octane oxidation	66.67	2 of 3
66794	IAA biosynthesis	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	66.67	2 of 3
66794	non-pathway related	65.79	25 of 38
66794	oxidative phosphorylation	64.84	59 of 91
66794	tetrahydrofolate metabolism	64.29	9 of 14
66794	androgen and estrogen metabolism	62.5	10 of 16
66794	dTDPLrhamnose biosynthesis	62.5	5 of 8
66794	ketogluconate metabolism	62.5	5 of 8
66794	degradation of pentoses	60.71	17 of 28
66794	arachidonate biosynthesis	60	3 of 5
66794	glycine metabolism	60	6 of 10
66794	gallate degradation	60	3 of 5
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	phenol degradation	55	11 of 20
66794	sulfate reduction	53.85	7 of 13
66794	phenylpropanoid biosynthesis	53.85	7 of 13
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	pantothenate biosynthesis	50	3 of 6
66794	carotenoid biosynthesis	50	11 of 22
66794	toluene degradation	50	2 of 4
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	lactate fermentation	50	2 of 4
66794	quinate degradation	50	1 of 2
66794	resorcinol degradation	50	1 of 2
66794	grixazone biosynthesis	50	1 of 2
66794	degradation of hexoses	50	9 of 18
66794	carnitine metabolism	50	4 of 8
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	vitamin B6 metabolism	45.45	5 of 11
66794	lipid A biosynthesis	44.44	4 of 9
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	ascorbate metabolism	40.91	9 of 22
66794	3-chlorocatechol degradation	40	2 of 5
66794	vitamin K metabolism	40	2 of 5
66794	coenzyme M biosynthesis	40	4 of 10
66794	3-phenylpropionate degradation	40	6 of 15
66794	bacilysin biosynthesis	40	2 of 5
66794	hydrogen production	40	2 of 5
66794	D-cycloserine biosynthesis	40	2 of 5
66794	O-antigen biosynthesis	40	2 of 5
66794	arachidonic acid metabolism	38.89	7 of 18
66794	d-xylose degradation	36.36	4 of 11
66794	enterobactin biosynthesis	33.33	1 of 3
66794	sulfoquinovose degradation	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	nitrate assimilation	33.33	3 of 9
66794	methanogenesis from CO2	33.33	4 of 12
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	phosphatidylethanolamine bioynthesis	30.77	4 of 13
66794	mevalonate metabolism	28.57	2 of 7
66794	chlorophyll metabolism	27.78	5 of 18
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	CMP-KDO biosynthesis	25	1 of 4
66794	alginate biosynthesis	25	1 of 4
66794	catecholamine biosynthesis	25	1 of 4

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM551946v1 assembly for Streptomyces clavuligerus ATCC 27064	complete	GCA_005519465	443255.68	2875420249	1901	99.04
66792	ASM1570860v1 assembly for Streptomyces clavuligerus ATCC 27064	complete	GCA_015708605	1901.22	8008551450	1901	98.58
66792	ASM2875255v1 assembly for Streptomyces clavuligerus DSM 738	complete	GCA_028752555	1901.65	8113078599	1901	98.3
66792	Streptomyces clavuligerus ATCC 27064	complete			2582581449	1901	96.43
66792	Scla_1.0 assembly for Streptomyces clavuligerus ATCC 27064	chromosome	GCA_000148465	443255.19	651324105	1901	71.55
66792	Strep_clav_ATCC27064 assembly for Streptomyces clavuligerus ATCC 27064	chromosome	GCA_000163875	443255.8	647533233	1901	33.45
66792	ASM1591239v1 assembly for Streptomyces clavuligerus ATCC 27064	contig	GCA_015912395	1901.34		1901
66792	ASM1591287v1 assembly for Streptomyces clavuligerus DSM 738	contig	GCA_015912875	1901.38	8119662975	1901
66792	ASM1591292v1 assembly for Streptomyces clavuligerus ATCC 27064	contig	GCA_015912925			1901
66792	ASM1591294v1 assembly for Streptomyces clavuligerus NCIMB 12785	contig	GCA_015912945	1901.40	8118197550	1901
66792	ASM1591243v1 assembly for Streptomyces clavuligerus NCIMB 14335	contig	GCA_015912435	1901.35	8118188922	1901
66792	ASM1591289v1 assembly for Streptomyces clavuligerus NRRL 3585	contig	GCA_015912895	1901.39	8118180317	1901
67770	ASM15492v1 assembly for Streptomyces clavuligerus ATCC 27064	scaffold	GCA_000154925	443255.6	2502894011	1901
66792	Streptomyces clavuligerus strain ATCC 27064	contig		1901.41		1901

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces clavuligerus gene for 16S rRNA, partial sequence	AB122716	564		443255
20218	Streptomyces clavuligerus gene for 16S rRNA	AB045869	1486		443255
20218	Streptomyces clavuligerus gene for 16S rRNA, partial sequence, strain: NBRC 13307	AB184343	1462		443255
20218	Streptomyces clavuligerus 16S ribosomal RNA gene, partial sequence	AF417600	356		443255
20218	Streptomyces clavuligerus ATCC 27064 strain NRRL 3585 16S ribosomal RNA gene, partial sequence	AY999718	1448		443255

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Genomic Diversity of Streptomyces clavuligerus: Implications for Clavulanic Acid Biosynthesis and Industrial Hyperproduction.	Rios-Fernandez P, Caicedo-Montoya C, Rios-Estepa R.	Int J Mol Sci	10.3390/ijms252010992	2024
Metabolism	Identification and characterization of two types of amino acid-regulated acetyltransferases in actinobacteria.	Lu YX, Liu XX, Liu WB, Ye BC.	Biosci Rep	10.1042/bsr20170157	2017
Enzymology	Characterization of a broad-range disulfide reductase from Streptomyces clavuligerus and its possible role in beta-lactam antibiotic biosynthesis.	Aharonowitz Y, Av-Gay Y, Schreiber R, Cohen G.	J Bacteriol	10.1128/jb.175.3.623-629.1993	1993
	Thioredoxin-thioredoxin reductase system of Streptomyces clavuligerus: sequences, expression, and organization of the genes.	Cohen G, Yanko M, Mislovati M, Argaman A, Schreiber R, Av-Gay Y, Aharonowitz Y.	J Bacteriol	10.1128/jb.175.16.5159-5167.1993	1993
	Low-molecular-weight thiols in streptomycetes and their potential role as antioxidants.	Newton GL, Fahey RC, Cohen G, Aharonowitz Y.	J Bacteriol	10.1128/jb.175.9.2734-2742.1993	1993
Transcriptome	Eliciting Clavulanic Acid Biosynthesis: The Impact of Bacillus velezensis FZB42 on the Metabolism of Streptoyces clavuligerus ATCC 27064.	Patino LF, Caicedo-Montoya C, Pinilla-Mendoza L, Cuartas JH, Rios-Estepa R.	Metabolites	10.3390/metabo15050337	2025
	Identification of Small RNAs in Streptomyces clavuligerus Using High-Resolution Transcriptomics and Expression Profiling During Clavulanic Acid Production.	Caicedo-Montoya C, Patino LF, Rios-Estepa R.	Int J Mol Sci	10.3390/ijms252413472	2024
	Functional insights into Streptomyces isolates containing both clavulanic acid-like and carbapenem biosynthetic gene clusters.	Tahlan K, Shaikh AA, Liu J, Gupta K, AbuSara N, Srivastava SK, Deng A, Rouah A, Swackhamer MJ.	mSphere	10.1128/msphere.00188-25	2025
	Photosynthetic 1,8-cineole production using cyanobacteria.	Sakamaki Y, Ono M, Shigenari N, Chibazakura T, Shimomura K, Watanabe S.	Biosci Biotechnol Biochem	10.1093/bbb/zbad012	2023
	Effect of impeller type on cellular morphology and production of clavulanic acid by Streptomyces clavuligerus.	Bustamante MCC, Costa CLL, Esperanca MN, Mazziero VT, Cerri MO, Badino AC.	Braz J Microbiol	10.1007/s42770-024-01306-0	2024
	Effect of Soy Protein Products on Growth and Metabolism of Bacillus subtilis, Streptococcus lactis, and Streptomyces clavuligerus.	Wen W, Hu M, Gao Y, Zhang P, Meng W, Zhang F, Fan B, Wang F, Li S.	Foods	10.3390/foods13101525	2024
	Streptomyces clavuligerus: The Omics Era.	Liras P, Martin JF.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab072	2021
Genetics	Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents.	Tarasova EV, Luchnikova NA, Grishko VV, Ivshina IB.	Pharmaceuticals (Basel)	10.3390/ph16060872	2023
	Clavulanic Acid Production by Streptomyces clavuligerus: Insights from Systems Biology, Strain Engineering, and Downstream Processing.	Lopez-Agudelo VA, Gomez-Rios D, Ramirez-Malule H.	Antibiotics (Basel)	10.3390/antibiotics10010084	2021
	Peptide surfactants with post-translational C-methylations that promote bacterial development.	Zhang C, Li Y, Overton EN, Seyedsayamdost MR.	Nat Chem Biol	10.1038/s41589-025-01882-8	2025
	Targeted Discovery of Cryptic Metabolites with Antiproliferative Activity.	Han EJ, Lee SR, Hoshino S, Seyedsayamdost MR.	ACS Chem Biol	10.1021/acschembio.2c00588	2022
	Complete Genome Sequence of Streptomyces clavuligerus F613-1, an Industrial Producer of Clavulanic Acid.	Cao G, Zhong C, Zong G, Fu J, Liu Z, Zhang G, Qin R.	Genome Announc	10.1128/genomea.01020-16	2016
	Role of fourteen XRE-DUF397 pairs from Streptomyces coelicolor as regulators of antibiotic production and differentiation. New players in a complex regulatory network.	Riascos C, Martinez-Carrasco A, Diaz M, Santamaria RI.	Front Microbiol	10.3389/fmicb.2023.1217350	2023
	CslA and GlxA from Streptomyces lividans form a functional cellulose synthase complex.	Zhong X, Nicolardi S, Ouyang R, Wuhrer M, Du C, van Wezel G, Vijgenboom E, Briegel A, Claessen D.	Appl Environ Microbiol	10.1128/aem.02087-23	2024
	Primary transcriptome and translatome analysis determines transcriptional and translational regulatory elements encoded in the Streptomyces clavuligerus genome.	Hwang S, Lee N, Jeong Y, Lee Y, Kim W, Cho S, Palsson BO, Cho BK.	Nucleic Acids Res	10.1093/nar/gkz471	2019
Metabolism	The roles of SARP family regulators involved in secondary metabolism in Streptomyces.	Yan Y, Xia H.	Front Microbiol	10.3389/fmicb.2024.1368809	2024
Transcriptome	Comparative Analysis of Strategies for De Novo Transcriptome Assembly in Prokaryotes: Streptomyces clavuligerus as a Case Study.	Caicedo-Montoya C, Pinilla L, Toro LF, Yepes-Garcia J, Rios-Estepa R.	High Throughput	10.3390/ht8040020	2019
	Specialized Metabolites from Ribosome Engineered Strains of Streptomyces clavuligerus.	Shaikh AA, Nothias LF, Srivastava SK, Dorrestein PC, Tahlan K.	Metabolites	10.3390/metabo11040239	2021
Transcriptome	Discovering the potential of S. clavuligerus for bioactive compound production: cross-talk between the chromosome and the pSCL4 megaplasmid.	Alvarez-Alvarez R, Martinez-Burgo Y, Rodriguez-Garcia A, Liras P.	BMC Genomics	10.1186/s12864-017-4289-y	2017
	Fermentation Conditions that Affect Clavulanic Acid Production in Streptomyces clavuligerus: A Systematic Review.	Ser HL, Law JW, Chaiyakunapruk N, Jacob SA, Palanisamy UD, Chan KG, Goh BH, Lee LH.	Front Microbiol	10.3389/fmicb.2016.00522	2016
	Comparative and pangenomic analysis of the genus Streptomyces.	Otani H, Udwary DW, Mouncey NJ.	Sci Rep	10.1038/s41598-022-21731-1	2022
Phylogeny	Critical analysis of polycyclic tetramate macrolactam biosynthetic gene cluster phylogeny and functional diversity.	Harper CP, Day A, Tsingos M, Ding E, Zeng E, Stumpf SD, Qi Y, Robinson A, Greif J, Blodgett JAV.	Appl Environ Microbiol	10.1128/aem.00600-24	2024
Metabolism	Molecular genetics of naringenin biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus.	Alvarez-Alvarez R, Botas A, Albillos SM, Rumbero A, Martin JF, Liras P.	Microb Cell Fact	10.1186/s12934-015-0373-7	2015
	A detailed view on 1,8-cineol biosynthesis by Streptomyces clavuligerus.	Rinkel J, Rabe P, Zur Horst L, Dickschat JS.	Beilstein J Org Chem	10.3762/bjoc.12.225	2016
Metabolism	Screening of medium constituents for clavulanic acid production by Streptomyces clavuligerus.	Rodrigues KCDS, Souza AT, Badino AC, Pedrolli DB, Cerri MO.	Braz J Microbiol	10.1016/j.bjm.2018.01.006	2018
	Efficient production of secretory Streptomyces clavuligerus beta-lactamase inhibitory protein (BLIP) in Pichia pastoris.	Law KH, Tsang MW, Wong YK, Tsang MS, Lau PY, Wong KY, Ho KP, Leung YC.	AMB Express	10.1186/s13568-018-0586-3	2018
Genetics	Pan-Genome of the Genus Streptomyces and Prioritization of Biosynthetic Gene Clusters With Potential to Produce Antibiotic Compounds.	Caicedo-Montoya C, Manzo-Ruiz M, Rios-Estepa R.	Front Microbiol	10.3389/fmicb.2021.677558	2021
Metabolism	Genome-wide gene expression changes in an industrial clavulanic acid overproduction strain of Streptomyces clavuligerus.	Medema MH, Alam MT, Heijne WH, van den Berg MA, Muller U, Trefzer A, Bovenberg RA, Breitling R, Takano E.	Microb Biotechnol	10.1111/j.1751-7915.2010.00226.x	2011
Phylogeny	Re-classification of Streptomyces venezuelae strains and mining secondary metabolite biosynthetic gene clusters.	Lee N, Choi M, Kim W, Hwang S, Lee Y, Kim JH, Kim G, Kim H, Cho S, Kim SC, Palsson B, Jang KS, Cho BK.	iScience	10.1016/j.isci.2021.103410	2021
Metabolism	The Impacts of Microgravity on Bacterial Metabolism.	Sharma G, Curtis PD.	Life (Basel)	10.3390/life12060774	2022
Metabolism	Enhancing effect of lysine combined with other compounds on cephamycin C production in Streptomyces clavuligerus.	Leite CA, Cavallieri AP, Araujo ML.	BMC Microbiol	10.1186/1471-2180-13-296	2013
Genetics	Comparative Genomic Analyses of the Genus Photobacterium Illuminate Biosynthetic Gene Clusters Associated with Antagonism.	Lau NS, Heng WL, Miswan N, Azami NA, Furusawa G.	Int J Mol Sci	10.3390/ijms23179712	2022
	Sulfane Sulfur Posttranslationally Modifies the Global Regulator AdpA to Influence Actinorhodin Production and Morphological Differentiation of Streptomyces coelicolor.	Lu T, Wu X, Cao Q, Xia Y, Xun L, Liu H.	mBio	10.1128/mbio.03862-21	2022
	Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis	Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NPJ, Deng Z.	Protein & cell.		2010
Genetics	Mini review: Genome mining approaches for the identification of secondary metabolite biosynthetic gene clusters in Streptomyces.	Lee N, Hwang S, Kim J, Cho S, Palsson B, Cho BK.	Comput Struct Biotechnol J	10.1016/j.csbj.2020.06.024	2020
Metabolism	Induction of holomycin production and complex metabolic changes by the argR mutation in Streptomyces clavuligerus NP1.	Yin H, Xiang S, Zheng J, Fan K, Yu T, Yang X, Peng Y, Wang H, Feng D, Luo Y, Bai H, Yang K.	Appl Environ Microbiol	10.1128/aem.07699-11	2012
Metabolism	Effects of spaceflight and simulated microgravity on microbial growth and secondary metabolism.	Huang B, Li DG, Huang Y, Liu CT.	Mil Med Res	10.1186/s40779-018-0162-9	2018
	Utilization of vegetable oil in the production of clavulanic acid by Streptomyces clavuligerus ATCC 27064.	Maranesi GL, Baptista-Neto A, Hokka CO, Badino AC.	World J Microbiol Biotechnol	10.1007/s11274-004-2393-z	2005
Metabolism	Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.	Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K.	Appl Environ Microbiol	10.1128/aem.00693-17	2017
Metabolism	High-throughput screening for Streptomyces antibiotic biosynthesis activators.	Chen L, Wang Y, Guo H, Xu M, Deng Z, Tao M.	Appl Environ Microbiol	10.1128/aem.00348-12	2012
	beta-Lactam potentiators to re-sensitize resistant pathogens: Discovery, development, clinical use and the way forward.	Narendrakumar L, Chakraborty M, Kumari S, Paul D, Das B.	Front Microbiol	10.3389/fmicb.2022.1092556	2022
Metabolism	Exploiting adaptive laboratory evolution of Streptomyces clavuligerus for antibiotic discovery and overproduction.	Charusanti P, Fong NL, Nagarajan H, Pereira AR, Li HJ, Abate EA, Su Y, Gerwick WH, Palsson BO.	PLoS One	10.1371/journal.pone.0033727	2012
Metabolism	Holomycin, an Antibiotic Secondary Metabolite, Is Required for Biofilm Formation by the Native Producer Photobacterium galatheae S2753.	Zhang SD, Isbrandt T, Lindqvist LL, Larsen TO, Gram L.	Appl Environ Microbiol	10.1128/aem.00169-21	2021
Genetics	Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery.	Malit JJL, Leung HYC, Qian PY.	Mar Drugs	10.3390/md20060398	2022
	Production of beta-Lactamase Inhibitors by Streptomyces Species.	Viana Marques DA, Machado SEF, Ebinuma VCS, Duarte CAL, Converti A, Porto ALF.	Antibiotics (Basel)	10.3390/antibiotics7030061	2018
Genetics	Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight Into Specialized Metabolism.	AbuSara NF, Piercey BM, Moore MA, Shaikh AA, Nothias LF, Srivastava SK, Cruz-Morales P, Dorrestein PC, Barona-Gomez F, Tahlan K.	Front Microbiol	10.3389/fmicb.2019.02550	2019
Metabolism	Isolation of beta-1,3-Glucanase-Producing Microorganisms from Poria cocos Cultivation Soil via Molecular Biology.	Wu Q, Dou X, Wang Q, Guan Z, Cai Y, Liao X.	Molecules	10.3390/molecules23071555	2018
Metabolism	Iterative combinatorial mutagenesis as an effective strategy for generation of deacetoxycephalosporin C synthase with improved activity toward penicillin G.	Ji J, Fan K, Tian X, Zhang X, Zhang Y, Yang K.	Appl Environ Microbiol	10.1128/aem.02122-12	2012
	Comparative Genomic Analysis of Soil Dwelling Bacteria Utilizing a Combinational Codon Usage and Molecular Phylogenetic Approach Accentuating on Key Housekeeping Genes.	Saha J, Saha BK, Pal Sarkar M, Roy V, Mandal P, Pal A.	Front Microbiol	10.3389/fmicb.2019.02896	2019
Metabolism	A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis.	Qin Z, Devine R, Hutchings MI, Wilkinson B.	Nat Commun	10.1038/s41467-019-11538-6	2019
Metabolism	CO synthesized from the central one-carbon pool as source for the iron carbonyl in O2-tolerant [NiFe]-hydrogenase.	Burstel I, Siebert E, Frielingsdorf S, Zebger I, Friedrich B, Lenz O.	Proc Natl Acad Sci U S A	10.1073/pnas.1614656113	2016
Genetics	Strategies and approaches in plasmidome studies-uncovering plasmid diversity disregarding of linear elements?	Dib JR, Wagenknecht M, Farias ME, Meinhardt F.	Front Microbiol	10.3389/fmicb.2015.00463	2015
Metabolism	The role of acyl-coenzyme A carboxylase complex in lipstatin biosynthesis of Streptomyces toxytricini.	Demirev AV, Khanal A, Sedai BR, Lim SK, Na MK, Nam DH.	Appl Microbiol Biotechnol	10.1007/s00253-010-2587-2	2010
Transcriptome	In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.	Marsh AJ, O'Sullivan O, Ross RP, Cotter PD, Hill C.	BMC Genomics	10.1186/1471-2164-11-679	2010
Genetics	Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.	Rudolf JD, Yan X, Shen B.	J Ind Microbiol Biotechnol	10.1007/s10295-015-1671-0	2016
Enzymology	Identification and functional analysis of cytochrome P450 complement in Streptomyces virginiae IBL14.	Li ZZ, Li XF, Yang W, Dong X, Yu J, Zhu SL, Li M, Xie L, Tong WY.	BMC Genomics	10.1186/1471-2164-14-130	2013
Metabolism	Bacterial Semiochemicals and Transkingdom Interactions with Insects and Plants.	Calcagnile M, Tredici SM, Tala A, Alifano P.	Insects	10.3390/insects10120441	2019
Metabolism	Amalgamation of nucleosides and amino acids in antibiotic biosynthesis: discovery of an L-threonine:uridine-5'-aldehyde transaldolase.	Barnard-Britson S, Chi X, Nonaka K, Spork AP, Tibrewal N, Goswami A, Pahari P, Ducho C, Rohr J, Van Lanen SG.	J Am Chem Soc	10.1021/ja308185q	2012
Metabolism	Modified Deacetylcephalosporin C Synthase for the Biotransformation of Semisynthetic Cephalosporins.	Balakrishnan N, Ganesan S, Rajasekaran P, Rajendran L, Teddu S, Durairaaj M.	Appl Environ Microbiol	10.1128/aem.00174-16	2016
Genetics	Exploring the Potential of Antibiotic Production From Rare Actinobacteria by Whole-Genome Sequencing and Guided MS/MS Analysis.	Hu D, Sun C, Jin T, Fan G, Mok KM, Li K, Lee SM.	Front Microbiol	10.3389/fmicb.2020.01540	2020
Genetics	Extremophile Metal Resistance: Plasmid-Encoded Functions in Streptomyces mirabilis.	Brangsch H, Holler M, Kraube T, Waqas M, Schroeckh V, Brakhage AA, Bunk B, Sproer C, Overmann J, Kothe E.	Appl Environ Microbiol	10.1128/aem.00085-22	2022
Enzymology	Identification of a fungal 1,8-cineole synthase from Hypoxylon sp. with specificity determinants in common with the plant synthases.	Shaw JJ, Berbasova T, Sasaki T, Jefferson-George K, Spakowicz DJ, Dunican BF, Portero CE, Narvaez-Trujillo A, Strobel SA.	J Biol Chem	10.1074/jbc.m114.636159	2015
	Mining methods and typical structural mechanisms of terpene cyclases.	Huang ZY, Ye RY, Yu HL, Li AT, Xu JH.	Bioresour Bioprocess	10.1186/s40643-021-00421-2	2021
Metabolism	Cloning and characterization of the polyether salinomycin biosynthesis gene cluster of Streptomyces albus XM211.	Jiang C, Wang H, Kang Q, Liu J, Bai L.	Appl Environ Microbiol	10.1128/aem.06701-11	2012
	Structural Basis of Catalysis in the Bacterial Monoterpene Synthases Linalool Synthase and 1,8-Cineole Synthase.	Karuppiah V, Ranaghan KE, Leferink NGH, Johannissen LO, Shanmugam M, Ni Cheallaigh A, Bennett NJ, Kearsey LJ, Takano E, Gardiner JM, van der Kamp MW, Hay S, Mulholland AJ, Leys D, Scrutton NS.	ACS Catal	10.1021/acscatal.7b01924	2017
	Mutants of Streptomyces clavuligerus with disruptions in different genes for clavulanic acid biosynthesis produce large amounts of holomycin: possible cross-regulation of two unrelated secondary metabolic pathways.	de la Fuente A, Lorenzana LM, Martin JF, Liras P.	J Bacteriol	10.1128/jb.184.23.6559-6565.2002	2002
Metabolism	Functional Cross-Talk of MbtH-Like Proteins During Thaxtomin Biosynthesis in the Potato Common Scab Pathogen Streptomyces scabiei.	Li Y, Tahlan K, Bignell DRD.	Front Microbiol	10.3389/fmicb.2020.585456	2020
Metabolism	Novel bioactive natural products from bacteria via bioprospecting, genome mining and metabolic engineering.	Sekurova ON, Schneider O, Zotchev SB.	Microb Biotechnol	10.1111/1751-7915.13398	2019
Metabolism	A natural plasmid uniquely encodes two biosynthetic pathways creating a potent anti-MRSA antibiotic.	Fukuda D, Haines AS, Song Z, Murphy AC, Hothersall J, Stephens ER, Gurney R, Cox RJ, Crosby J, Willis CL, Simpson TJ, Thomas CM.	PLoS One	10.1371/journal.pone.0018031	2011
Metabolism	Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.	Lorenzana LM, Perez-Redondo R, Santamarta I, Martin JF, Liras P.	J Bacteriol	10.1128/jb.186.11.3431-3438.2004	2004
Metabolism	The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.	Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A.	BMC Genomics	10.1186/1471-2164-13-112	2012
Metabolism	Nitrogen Substrate Utilization in Three Rhizosphere Bacterial Strains Investigated Using Proteomics.	Jacoby RP, Succurro A, Kopriva S.	Front Microbiol	10.3389/fmicb.2020.00784	2020
Transcriptome	Transcriptome and translatome profiles of Streptomyces species in different growth phases.	Kim W, Hwang S, Lee N, Lee Y, Cho S, Palsson B, Cho BK.	Sci Data	10.1038/s41597-020-0476-9	2020
Enzymology	Bioassay- and metabolomics-guided screening of bioactive soil actinomycetes from the ancient city of Ihnasia, Egypt.	Sebak M, Saafan AE, AbdelGhani S, Bakeer W, El-Gendy AO, Espriu LC, Duncan K, Edrada-Ebel R.	PLoS One	10.1371/journal.pone.0226959	2019
	A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.	Perez-Llarena FJ, Liras P, Rodriguez-Garcia A, Martin JF.	J Bacteriol	10.1128/jb.179.6.2053-2059.1997	1997
	Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.	Zhang W, Ostash B, Walsh CT.	Proc Natl Acad Sci U S A	10.1073/pnas.1011557107	2010
Enzymology	Two proteins with ornithine acetyltransferase activity show different functions in Streptomyces clavuligerus: Oat2 modulates clavulanic acid biosynthesis in response to arginine.	de la Fuente A, Martin JF, Rodriguez-Garcia A, Liras P.	J Bacteriol	10.1128/jb.186.19.6501-6507.2004	2004
Metabolism	Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights.	Goto Y, Li B, Claesen J, Shi Y, Bibb MJ, van der Donk WA.	PLoS Biol	10.1371/journal.pbio.1000339	2010
Biotechnology	Advanced Methods for Natural Products Discovery: Bioactivity Screening, Dereplication, Metabolomics Profiling, Genomic Sequencing, Databases and Informatic Tools, and Structure Elucidation.	Gaudencio SP, Bayram E, Lukic Bilela L, Cueto M, Diaz-Marrero AR, Haznedaroglu BZ, Jimenez C, Mandalakis M, Pereira F, Reyes F, Tasdemir D.	Mar Drugs	10.3390/md21050308	2023
	Identification and characterization of Streptomyces flavogriseus NJ-4 as a novel producer of actinomycin D and holomycin.	Wei Z, Xu C, Wang J, Lu F, Bie X, Lu Z.	PeerJ	10.7717/peerj.3601	2017
	Expansion of the clavulanic acid gene cluster: identification and in vivo functional analysis of three new genes required for biosynthesis of clavulanic acid by Streptomyces clavuligerus.	Li R, Khaleeli N, Townsend CA.	J Bacteriol	10.1128/jb.182.14.4087-4095.2000	2000
Metabolism	O-Methyltransferase-Mediated Incorporation of a beta-Amino Acid in Lanthipeptides.	Acedo JZ, Bothwell IR, An L, Trouth A, Frazier C, van der Donk WA.	J Am Chem Soc	10.1021/jacs.9b07396	2019
Metabolism	Identification and characterization of the carbapenem MM 4550 and its gene cluster in Streptomyces argenteolus ATCC 11009.	Li R, Lloyd EP, Moshos KA, Townsend CA.	Chembiochem	10.1002/cbic.201300319	2014
Genetics	Osmotic Adaptation and Compatible Solute Biosynthesis of Phototrophic Bacteria as Revealed from Genome Analyses.	Imhoff JF, Rahn T, Kunzel S, Keller A, Neulinger SC.	Microorganisms	10.3390/microorganisms9010046	2020
Metabolism	Family shuffling of expandase genes to enhance substrate specificity for penicillin G.	Hsu JS, Yang YB, Deng CH, Wei CL, Liaw SH, Tsai YC.	Appl Environ Microbiol	10.1128/aem.70.10.6257-6263.2004	2004
Metabolism	Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.	de La Fuente JL, Rumbero A, Martin JF, Liras P.	Biochem J		1997
Metabolism	Cloning and expression analysis of the pcbAB-pcbC beta-lactam genes in the marine fungus Kallichroma tethys.	Kim CF, Lee SK, Price J, Jack RW, Turner G, Kong RY.	Appl Environ Microbiol	10.1128/aem.69.2.1308-1314.2003	2003
	The bla gene of the cephamycin cluster of Streptomyces clavuligerus encodes a class A beta-lactamase of low enzymatic activity.	Perez-Llarena F, Martin JF, Galleni M, Coque JJ, Fuente JL, Frere JM, Liras P.	J Bacteriol	10.1128/jb.179.19.6035-6040.1997	1997
Enzymology	Terpene synthases are widely distributed in bacteria.	Yamada Y, Kuzuyama T, Komatsu M, Shin-Ya K, Omura S, Cane DE, Ikeda H.	Proc Natl Acad Sci U S A	10.1073/pnas.1422108112	2015
Metabolism	Counteraction of antibiotic production and degradation stabilizes microbial communities.	Kelsic ED, Zhao J, Vetsigian K, Kishony R.	Nature	10.1038/nature14485	2015
Genetics	A computational framework to explore large-scale biosynthetic diversity.	Navarro-Munoz JC, Selem-Mojica N, Mullowney MW, Kautsar SA, Tryon JH, Parkinson EI, De Los Santos ELC, Yeong M, Cruz-Morales P, Abubucker S, Roeters A, Lokhorst W, Fernandez-Guerra A, Cappelini LTD, Goering AW, Thomson RJ, Metcalf WW, Kelleher NL, Barona-Gomez F, Medema MH.	Nat Chem Biol	10.1038/s41589-019-0400-9	2020
Metabolism	The adnAB locus, encoding a putative helicase-nuclease activity, is essential in Streptomyces.	Zhang L, Nguyen HC, Chipot L, Piotrowski E, Bertrand C, Thibessard A, Leblond P.	J Bacteriol	10.1128/jb.01513-14	2014
Metabolism	Investigation of the Streptomyces clavuligerus cephamycin C gene cluster and its regulation by the CcaR protein.	Alexander DC, Jensen SE.	J Bacteriol	10.1128/jb.180.16.4068-4079.1998	1998
Phylogeny	Cytochrome P450 diversity in the tree of life.	Nelson DR.	Biochim Biophys Acta Proteins Proteom	10.1016/j.bbapap.2017.05.003	2018
Metabolism	Deletion of the pyc gene blocks clavulanic acid biosynthesis except in glycerol-containing medium: evidence for two different genes in formation of the C3 unit.	Perez-Redondo R, Rodriguez-Garcia A, Martin JF, Liras P.	J Bacteriol	10.1128/jb.181.22.6922-6928.1999	1999
Metabolism	Precursor flux control through targeted chromosomal insertion of the lysine epsilon-aminotransferase (lat) gene in cephamycin C biosynthesis.	Malmberg LH, Hu WS, Sherman DH.	J Bacteriol	10.1128/jb.175.21.6916-6924.1993	1993
	The beta-lactam biosynthesis genes for isopenicillin N epimerase and deacetoxycephalosporin C synthetase are expressed from a single transcript in Streptomyces clavuligerus.	Kovacevic S, Tobin MB, Miller JR.	J Bacteriol	10.1128/jb.172.7.3952-3958.1990	1990
Metabolism	Molecular cloning and heterologous expression of a biosynthetic gene cluster for the antitubercular agent D-cycloserine produced by Streptomyces lavendulae.	Kumagai T, Koyama Y, Oda K, Noda M, Matoba Y, Sugiyama M.	Antimicrob Agents Chemother	10.1128/aac.01226-09	2010
Enzymology	Cloning, characterization, and expression in Escherichia coli of the Streptomyces clavuligerus gene encoding deacetoxycephalosporin C synthetase.	Kovacevic S, Weigel BJ, Tobin MB, Ingolia TD, Miller JR.	J Bacteriol	10.1128/jb.171.2.754-760.1989	1989
Metabolism	Lack of A-factor production induces the expression of nutrient scavenging and stress-related proteins in Streptomyces griseus.	Birko Z, Swiatek M, Szajli E, Medzihradszky KF, Vijgenboom E, Penyige A, Keseru J, van Wezel GP, Biro S.	Mol Cell Proteomics	10.1074/mcp.m900194-mcp200	2009
Metabolism	Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.	Blodgett JA, Oh DC, Cao S, Currie CR, Kolter R, Clardy J.	Proc Natl Acad Sci U S A	10.1073/pnas.1001513107	2010
Phylogeny	Genomic analysis reveals versatile organisms for quorum quenching enzymes: acyl-homoserine lactone-acylase and -lactonase.	Kalia VC, Raju SC, Purohit HJ.	Open Microbiol J	10.2174/1874285801105010001	2011
Enzymology	Streptomyces lipmanii expresses two restriction systems that inhibit plasmid transformation and bacteriophage plaque formation.	Matsushima P, Baltz RH.	J Bacteriol	10.1128/jb.171.6.3128-3132.1989	1989
Metabolism	Carbon catabolite regulation of cephalosporin production in Streptomyces clavuligerus.	Aharonowitz Y, Demain AL.	Antimicrob Agents Chemother	10.1128/aac.14.2.159	1978
Metabolism	Display of functional beta-lactamase inhibitory protein on the surface of M13 bacteriophage.	Huang W, Petrosino J, Palzkill T.	Antimicrob Agents Chemother	10.1128/aac.42.11.2893	1998
Pathogenicity	Effect of clavulanic acid on the minimum inhibitory concentration of benzylpenicillin, ampicillin, carbenicillin, or cephalothin against clinical isolates resistant to beta-lactam antibiotics.	Dumon L, Adriaens P, Anne J, Eyssen H.	Antimicrob Agents Chemother	10.1128/aac.15.2.315	1979
Metabolism	Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.	Zahn JA, Higgs RE, Hilton MD.	Appl Environ Microbiol	10.1128/aem.67.1.377-386.2001	2001
Metabolism	New superfamilies of eukaryotic DNA transposons and their internal divisions.	Bao W, Jurka MG, Kapitonov VV, Jurka J.	Mol Biol Evol	10.1093/molbev/msp013	2009
Phylogeny	A freshwater cyanophage whose genome indicates close relationships to photosynthetic marine cyanomyophages.	Dreher TW, Brown N, Bozarth CS, Schwartz AD, Riscoe E, Thrash C, Bennett SE, Tzeng SC, Maier CS.	Environ Microbiol	10.1111/j.1462-2920.2011.02502.x	2011
Metabolism	Biochemical properties of ectoine hydroxylases from extremophiles and their wider taxonomic distribution among microorganisms.	Widderich N, Hoppner A, Pittelkow M, Heider J, Smits SH, Bremer E.	PLoS One	10.1371/journal.pone.0093809	2014
	Effect of clavulanic Acid on anaerobic bacteria resistant to Beta-lactam antibiotics.	Wust J, Wilkins TD.	Antimicrob Agents Chemother	10.1128/aac.13.1.130	1978
	Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family.	Silverio AL, Saier MH.	J Membr Biol	10.1007/s00232-011-9364-8	2011
Genetics	Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.	Chandra G, Chater KF.	FEMS Microbiol Rev	10.1111/1574-6976.12047	2014
Transcriptome	Transcriptome profiles of Streptomyces clavuligerus strains producing different titers of clavulanic acid.	Gong J, Yi JS, Cho HS, Shin CH, Won HJ, Cho BK, Noh M, Yoon YJ.	Sci Data	10.1038/s41597-023-02727-6	2023
Metabolism	Enhanced production of clavulanic acid by improving glycerol utilization using reporter-guided mutagenesis of an industrial Streptomyces clavuligerus strain.	Shin CH, Cho HS, Won HJ, Kwon HJ, Kim CW, Yoon YJ.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab004	2021
Enzymology	Homologous expression of lysA encoding diaminopimelic acid (DAP) decarboxylase reveals increased antibiotic production in Streptomyces clavuligerus.	Otur C, Kurt-Kizildogan A.	Braz J Microbiol	10.1007/s42770-019-00202-2	2020
	Deacetoxycephalosporin C synthase (expandase): Research progress and application potential.	Niu X, Zhang J, Xue X, Wang D, Wang L, Gao Q.	Synth Syst Biotechnol	10.1016/j.synbio.2021.11.001	2021
Metabolism	Genome sequences of three tunicamycin-producing Streptomyces Strains, S. chartreusis NRRL 12338, S. chartreusis NRRL 3882, and S. lysosuperificus ATCC 31396.	Doroghazi JR, Ju KS, Brown DW, Labeda DP, Deng Z, Metcalf WW, Chen W, Price NP.	J Bacteriol	10.1128/jb.06262-11	2011
	In vivo functional analysis of a class A beta-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.	Srivastava SK, King KS, AbuSara NF, Malayny CJ, Piercey BM, Wilson JA, Tahlan K.	PLoS One	10.1371/journal.pone.0215960	2019
	The Identification and Conservation of Tunicaminyluracil-Related Biosynthetic Gene Clusters in Several Rathayibacter Species Collected From Australia, Africa, Eurasia, and North America.	Tancos MA, Sechler AJ, Davis EW, Chang JH, Schroeder BK, Murray TD, Rogers EE.	Front Microbiol	10.3389/fmicb.2019.02914	2019
Enzymology	Carboxyethylarginine synthase genes show complex cross-regulation in Streptomyces clavuligerus.	Kwong T, Tahlan K, Anders CL, Jensen SE.	Appl Environ Microbiol	10.1128/aem.02600-12	2013
Metabolism	The pcd gene encoding piperideine-6-carboxylate dehydrogenase involved in biosynthesis of alpha-aminoadipic acid is located in the cephamycin cluster of Streptomyces clavuligerus.	Perez-Llarena FJ, Rodriguez-Garcia A, Enguita FJ, Martin JF, Liras P.	J Bacteriol	10.1128/jb.180.17.4753-4756.1998	1998
Metabolism	pcd mutants of Streptomyces clavuligerus still produce cephamycin C.	Alexander DC, Anders CL, Lee L, Jensen SE.	J Bacteriol	10.1128/jb.00712-07	2007
Metabolism	Relevant double mutations in bioengineered Streptomyces clavuligerus deacetoxycephalosporin C synthase result in higher binding specificities which improve penicillin bioconversion.	Goo KS, Chua CS, Sim TS.	Appl Environ Microbiol	10.1128/aem.02230-07	2008
Metabolism	Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.	Bignell DR, Tahlan K, Colvin KR, Jensen SE, Leskiw BK.	Antimicrob Agents Chemother	10.1128/aac.49.4.1529-1541.2005	2005
Metabolism	Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.	Paradkar AS, Mosher RH, Anders C, Griffin A, Griffin J, Hughes C, Greaves P, Barton B, Jensen SE.	Appl Environ Microbiol	10.1128/aem.67.5.2292-2297.2001	2001
	Mechanism-of-Action Classification of Antibiotics by Global Transcriptome Profiling.	O'Rourke A, Beyhan S, Choi Y, Morales P, Chan AP, Espinoza JL, Dupont CL, Meyer KJ, Spoering A, Lewis K, Nierman WC, Nelson KE.	Antimicrob Agents Chemother	10.1128/aac.01207-19	2020
Enzymology	Cloning and characterization of the isopenicillin N synthase gene of Streptomyces griseus NRRL 3851 and studies of expression and complementation of the cephamycin pathway in Streptomyces clavuligerus.	Garcia-Dominguez M, Liras P, Martin JF.	Antimicrob Agents Chemother	10.1128/aac.35.1.44	1991
Enzymology	Streptomyces clavuligerus has a second copy of the proclavaminate amidinohydrolase gene.	Jensen SE, Wong A, Griffin A, Barton B.	Antimicrob Agents Chemother	10.1128/aac.48.2.514-520.2004	2004
	Characterization of the Streptomyces clavuligerus argC gene encoding N-acetylglutamyl-phosphate reductase: expression in Streptomyces lividans and effect on clavulanic acid production.	Ludovice M, Martin JF, Carrachas P, Liras P.	J Bacteriol	10.1128/jb.174.14.4606-4613.1992	1992
	Molecular analysis of a beta-lactam resistance gene encoded within the cephamycin gene cluster of Streptomyces clavuligerus.	Paradkar AS, Aidoo KA, Wong A, Jensen SE.	J Bacteriol	10.1128/jb.178.21.6266-6274.1996	1996
Enzymology	Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.	Jensen SE, Elder KJ, Aidoo KA, Paradkar AS.	Antimicrob Agents Chemother	10.1128/aac.44.3.720-726.2000	2000
Metabolism	Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria.	Dubeau MP, Ghinet MG, Jacques PE, Clermont N, Beaulieu C, Brzezinski R.	Appl Environ Microbiol	10.1128/aem.02139-08	2009
	Cloning and sequencing of the beta-lactam hydroxylase gene (cefF) from Streptomyces clavuligerus: gene duplication may have led to separate hydroxylase and expandase activities in the actinomycetes.	Kovacevic S, Miller JR.	J Bacteriol	10.1128/jb.173.1.398-400.1991	1991
Metabolism	Utilization of ornithine and arginine as specific precursors of clavulanic acid.	Romero J, Liras P, Martin JF.	Appl Environ Microbiol	10.1128/aem.52.4.892-897.1986	1986
	Early cephamycin biosynthetic genes are expressed from a polycistronic transcript in Streptomyces clavuligerus.	Alexander DC, Brumlik MJ, Lee L, Jensen SE.	J Bacteriol	10.1128/jb.182.2.348-356.2000	2000
	Efficient plasmid transformation of the beta-lactam producer Streptomyces clavuligerus.	Garcia-Dominguez M, Martin JF, Mahro B, Demain AL, Liras P.	Appl Environ Microbiol	10.1128/aem.53.6.1376-1381.1987	1987
Enzymology	Purification and partial characterization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.	Jensen SE, Wong A, Rollins MJ, Westlake DW.	J Bacteriol	10.1128/jb.172.12.7269-7271.1990	1990
Metabolism	Five additional genes are involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.	Jensen SE, Paradkar AS, Mosher RH, Anders C, Beatty PH, Brumlik MJ, Griffin A, Barton B.	Antimicrob Agents Chemother	10.1128/aac.48.1.192-202.2004	2004
Metabolism	Lysine catabolism in Streptomyces spp. is primarily through cadaverine: beta-lactam producers also make alpha-aminoadipate.	Madduri K, Stuttard C, Vining LC.	J Bacteriol	10.1128/jb.171.1.299-302.1989	1989
	Cloning and location of a gene governing lysine epsilon-aminotransferase, an enzyme initiating beta-lactam biosynthesis in Streptomyces spp.	Madduri K, Stuttard C, Vining LC.	J Bacteriol	10.1128/jb.173.3.985-988.1991	1991
	Functional analysis of the gene encoding the clavaminate synthase 2 isoenzyme involved in clavulanic acid biosynthesis in Streptomyces clavuligerus.	Paradkar AS, Jensen SE.	J Bacteriol	10.1128/jb.177.5.1307-1314.1995	1995
Enzymology	Localization of the lysine epsilon-aminotransferase (lat) and delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase (pcbAB) genes from Streptomyces clavuligerus and production of lysine epsilon-aminotransferase activity in Escherichia coli.	Tobin MB, Kovacevic S, Madduri K, Hoskins JA, Skatrud PL, Vining LC, Stuttard C, Miller JR.	J Bacteriol	10.1128/jb.173.19.6223-6229.1991	1991
Metabolism	Regulatory mutants of Streptomyces clavuligerus affected in free diaminopimelic acid content and antibiotic biosynthesis.	Aharonowitz Y, Mendelovitz S, Kirenberg F, Kuper V.	J Bacteriol	10.1128/jb.157.1.337-340.1984	1984
Metabolism	Analysis of penicillin N ring expansion activity from Streptomyces clavuligerus by ion-pair high-pressure liquid chromatography.	Jensen SE, Westlake DW, Wolfe S.	Antimicrob Agents Chemother	10.1128/aac.24.3.307	1983
Enzymology	Detection of a cephalosporin C acetyl esterase in the carbamate cephalosporin antibiotic-producing culture, Streptomyces clavuligerus.	Brannon DR, Fukuda DS, Mabe JA, Huber FM, Whitney JG.	Antimicrob Agents Chemother	10.1128/aac.1.3.237	1972
Enzymology	Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene.	Doran JL, Leskiw BK, Aippersbach S, Jensen SE.	J Bacteriol	10.1128/jb.172.9.4909-4918.1990	1990
	Complete nucleotide sequence of a linear plasmid from Streptomyces clavuligerus and characterization of its RNA transcripts.	Wu X, Roy KL.	J Bacteriol	10.1128/jb.175.1.37-52.1993	1993
	Genome structure in Streptomyces spp.: adjacent genes on the S. coelicolor A3(2) linkage map have cotransducible analogs in S. venezuelae.	Stuttard C, Atkinson L, Vats S.	J Bacteriol	10.1128/jb.169.8.3814-3816.1987	1987
	Origin of glycine from acid hydrolysis of the -lactam antibiotic A16886B.	Brannon DR, Mabe JA, Ellis R, Whitney JG, Nagarajan R.	Antimicrob Agents Chemother	10.1128/aac.1.3.242	1972
Phylogeny	Kinship and diversification of bacterial penicillin-binding proteins and beta-lactamases.	Massova I, Mobashery S.	Antimicrob Agents Chemother	10.1128/aac.42.1.1	1998
	Antimicrobial activity of omwaprin, a new member of the waprin family of snake venom proteins.	Nair DG, Fry BG, Alewood P, Kumar PP, Kini RM.	Biochem J	10.1042/bj20060318	2007
Metabolism	Recombinant organisms for production of industrial products.	Adrio JL, Demain AL.	Bioeng Bugs	10.4161/bbug.1.2.10484	2010
Metabolism	Penicillin-binding proteins of Streptomyces cacaoi, Streptomyces olivaceus, and Streptomyces clavuligerus.	Ogawara H, Horikawa S.	Antimicrob Agents Chemother	10.1128/aac.17.1.1	1980
	Exploring the bioactive potential of rhizospheric Streptomyces clavuligerus against Macrophomina phaseolina, an incitant of groundnut dry root rot disease.	PalaniArul P, Kathithachalam A, Muthusamy K, Sankarasubramanian H, Rangasamy A, Boopathi Narayanan M, Mannu J, Marimuthu M.	Microb Pathog	10.1016/j.micpath.2025.108093	2025
	Integrated genomic-transcriptomic analysis of clavulanic acid production in differentially productive Streptomyces clavuligerus strains.	Gong J, Yi JS, An S, Cho HS, Shin CH, Won HJ, Lee N, Lee Y, Cho BK, Noh M, Yoon YJ.	Sci Rep	10.1038/s41598-025-29509-x	2025
	Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products.	Leferink NGH, Whitehead JN, Johannissen LO, Scrutton NS.	FEBS J	10.1111/febs.70308	2025
	Genetic Engineering of Yarrowia lipolytica for 1,8-cineole production: A sustainable approach.	Bhoir K, Prakash G, Odaneth A.	Enzyme Microb Technol	10.1016/j.enzmictec.2025.110659	2025
Transcriptome	Global regulator AdpA directly binds to tunicamycin gene cluster and negatively regulates tunicamycin biosynthesis in Streptomyces clavuligerus.	Otur C, Kurt-Kizildogan A.	World J Microbiol Biotechnol	10.1007/s11274-024-04160-2	2024
	From nature to cancer therapy: Evaluating the Streptomyces clavuligerus secondary metabolites for potential protein kinase inhibitors.	Saini R, Kumari S, Singh A, Mishra A.	J Cell Biochem	10.1002/jcb.30501	2024
	Discovery, Structure, and Engineering of a cis-Geranylfarnesyl Diphosphate Synthase.	Li FR, Wang Q, Pan X, Xu HM, Dong LB.	Angew Chem Int Ed Engl	10.1002/anie.202401669	2024
	The regulatory role of Fur-encoding SCLAV_3199 in iron homeostasis in Streptomyces clavuligerus.	Abanoz-Secgin B, Otur C, Okay S, Kurt-Kizildogan A.	Gene	10.1016/j.gene.2023.147594	2023
	Utilization of xylose enriched extract from spent lemongrass hydrolysate for clavulanic acid production using Streptomyces clavuligerus (MTCC 1142).	Kumar V, Radha A, Sharma V, Nekkala N, Saran S.	Bioresour Technol	10.1016/j.biortech.2023.129268	2023
	Targeted Discovery of Cryptic Enediyne Natural Products via FRET-Coupled High-Throughput Elicitor Screening.	Han EJ, Lee SR, Townsend CA, Seyedsayamdost MR.	ACS Chem Biol	10.1021/acschembio.3c00281	2023
	Discovery and biosynthesis of bacterial drimane-type sesquiterpenoids from Streptomyces clavuligerus.	Zhang D, Du W, Pan X, Lin X, Li FR, Wang Q, Yang Q, Xu HM, Dong LB.	Beilstein J Org Chem	10.3762/bjoc.20.73	2024
	Metabolic engineering of terpene metabolism in lavender.	Oseni OM, Sajaditabar R, Mahmoud SS.	Beni Suef Univ J Basic Appl Sci	10.1186/s43088-024-00524-7	2024
Metabolism	Harnessing glycerol for secondary metabolite biosynthesis in microorganisms.	Kamasaka K, Marcello L, Domingues L, Hasunuma T.	World J Microbiol Biotechnol	10.1007/s11274-025-04537-x	2025
	Effect of temperature on synthesis of clavulanic acid and impurity substance G during fermentation by Streptomyces clavuligerus.	Feng T, Zhao J, Bai YF, Chu J, Wang YH, Zhuang YP.	Prep Biochem Biotechnol	10.1080/10826068.2021.2009860	2022
	Statistical Optimizing of Medium for Clavulanic Acid Production by Streptomyces clavuligerus Using Response Surface Methodology.	Feng T, Zhao J, Chu J, Wang YH, Zhuang YP.	Appl Biochem Biotechnol	10.1007/s12010-021-03627-4	2021
	Whole-genome sequencing of the Streptomyces coelicolor bldA39 mutant (J1700) reveals hundreds of previously unknown mutations.	Stone JW, Munnoch JT, Hoskisson PA.	Access Microbiol	10.1099/acmi.0.000958.v3	2025
Metabolism	Individual effect of shear rate and oxygen transfer on clavulanic acid production by Streptomyces clavuligerus.	Ribeiro RMMGP, Esperanca MN, Sousa APA, Neto AB, Cerri MO.	Bioprocess Biosyst Eng	10.1007/s00449-021-02555-1	2021
	Evidence supporting a catalytic pentad mechanism for the proteasome and other N-terminal nucleophile enzymes.	Fung D, Razi A, Pandos M, Velez B, Fermin Perez E, Adams L, Rawson S, Walsh RM, Hanna J.	Nat Commun	10.1038/s41467-025-58077-x	2025
	Photoredox-catalyzed intramolecular nucleophilic amidation of alkenes with beta-lactams.	Giraldi V, Magagnano G, Giacomini D, Cozzi PG, Gualandi A.	Beilstein J Org Chem	10.3762/bjoc.20.210	2024
Transcriptome	Characterization of bacterial intrinsic transcription terminators identified with TERMITe-a novel method for comprehensive analysis of Term-seq data.	Kosinski JG, Ranaweera S, Chelkowska-Pauszek A, Kashlev M, Babitzke P, Zywicki M.	Nucleic Acids Res	10.1093/nar/gkaf553	2025
	Synthetic Protein Scaffolds for Improving R-(-)-Linalool Production in Escherichia coli.	Wu J, Wang X, Xiao L, Wang F, Zhang Y, Li X.	J Agric Food Chem	10.1021/acs.jafc.1c01101	2021
	Production of the Sesquiterpene Bisabolene From One- and Two-Carbon Compounds in Engineered Methanosarcina acetivorans.	Mentrup A, Scheitz LV, Wallenfang T, Rother M.	Microb Biotechnol	10.1111/1751-7915.70105	2025
Genetics	Biocontrol potential of newly isolated Streptomyces noursei D337-11 from disease suppressive soil and its metabolites against Fusarium oxysporum f. sp. cubense in banana plants.	Zhou D, He X, Chen Y, Li C, Wang W, Pan Z, Zhao Y, Wei Y, Feng J, Zhang M, Qi D, Li X, Li K, Jing T, Xie J.	Front Microbiol	10.3389/fmicb.2025.1655103	2025
Metabolism	Structure and mechanism of piperideine-6-carboxylate dehydrogenase from Streptomyces clavuligerus.	Hasse D, Hulsemann J, Carlsson GH, Valegard K, Andersson I.	Acta Crystallogr D Struct Biol	10.1107/s2059798319014852	2019
Transcriptome	Rich Organic Nitrogen Impacts Clavulanic Acid Biosynthesis through the Arginine Metabolic Pathway in Streptomyces clavuligerus F613-1.	Fu J, Xie X, Zhang S, Kang N, Zong G, Zhang P, Cao G.	Microbiol Spectr	10.1128/spectrum.02017-22	2023
Enzymology	Improved production of clavulanic acid by reverse engineering and overexpression of the regulatory genes in an industrial Streptomyces clavuligerus strain.	Cho HS, Jo JC, Shin CH, Lee N, Choi JS, Cho BK, Roe JH, Kim CW, Kwon HJ, Yoon YJ.	J Ind Microbiol Biotechnol	10.1007/s10295-019-02196-0	2019
	Stereospecific linalool production utilizing two-phase cultivation system in Pantoea ananatis.	Hoshino Y, Moriya M, Matsudaira A, Katashkina JI, Nitta N, Nishio Y, Usuda Y.	J Biotechnol	10.1016/j.jbiotec.2020.09.021	2020
Genetics	Exploring the microbial communities in coastal cenote and their hidden biotechnological potential.	Contreras-de la Rosa PA, De la Torre-Zavala S, O Connor-Sanchez A, Prieto-Davo A, Gongora-Castillo EB.	Microb Genom	10.1099/mgen.0.001382	2025
Metabolism	Efficient Biosynthesis of R-(-)-Linalool through Adjusting the Expression Strategy and Increasing GPP Supply in Escherichia coli.	Wang X, Wu J, Chen J, Xiao L, Zhang Y, Wang F, Li X.	J Agric Food Chem	10.1021/acs.jafc.0c03664	2020
Metabolism	Application of Acid and Cold Stresses to Enhance the Production of Clavulanic Acid by Streptomyces clavuligerus.	Rodrigues KCS, Costa CLL, Badino AC, Pedrolli DB, Pereira JFB, Cerri MO.	Appl Biochem Biotechnol	10.1007/s12010-019-02953-y	2019
	Simultaneous solid-liquid separation and primary purification of clavulanic acid from fermentation broth of Streptomyces clavuligerus using salting-out extraction system.	Wang XD, Hu CY, Qin C, Dong YS, Ying GQ, Xiu ZL, Su ZG.	Eng Life Sci	10.1002/elsc.202000091	2021
	Functional proteomic analysis of Streptomyces sp. F-3 reveals its potential to effectively degrade waste-yeast.	Liu M, Huang S, Yan P, Wu X, Yin H, Wang L.	Appl Microbiol Biotechnol	10.1007/s00253-025-13541-y	2025
Metabolism	Streptomyces clavuligerus shows a strong association between TCA cycle intermediate accumulation and clavulanic acid biosynthesis.	Ramirez-Malule H, Junne S, Nicolas Cruz-Bournazou M, Neubauer P, Rios-Estepa R.	Appl Microbiol Biotechnol	10.1007/s00253-018-8841-8	2018
Genetics	An enhanced genome-scale metabolic reconstruction of Streptomyces clavuligerus identifies novel strain improvement strategies.	Toro L, Pinilla L, Avignone-Rossa C, Rios-Estepa R.	Bioprocess Biosyst Eng	10.1007/s00449-018-1900-9	2018
Enzymology	Mechanisms of the Diterpene Cyclases beta-Pinacene Synthase from Dictyostelium discoideum and Hydropyrene Synthase from Streptomyces clavuligerus.	Rinkel J, Rabe P, Chen X, Kollner TG, Chen F, Dickschat JS.	Chemistry	10.1002/chem.201702704	2017
	Improvement of clavulanic acid production in Streptomyces clavuligerus F613-1 by using a claR-neo reporter strategy	Qin R, Zhong C, Zong G, Fu J, Pang X, Cao G.	Electron J Biotechnol	10.1016/j.ejbt.2017.05.002	2017
	Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model.	Gomez-Ceron S, Galindo-Betancur D, Ramirez-Malule H.	Data Brief	10.1016/j.dib.2019.103992	2019
	Insight into Structure-Function Relationships of beta-Lactamase and BLIPs Interface Plasticity using Protein-Protein Interactions.	Yadav TC, Agarwal V, Srivastava AK, Raghuwanshi N, Varadwaj P, Prasad R, Pruthi V.	Curr Pharm Des	10.2174/1381612825666190911154650	2019
	TCA Cycle and Its Relationship with Clavulanic Acid Production: A Further Interpretation by Using a Reduced Genome-Scale Metabolic Model of Streptomyces clavuligerus.	Ramirez-Malule H, Lopez-Agudelo VA, Gomez-Rios D, Ochoa S, Rios-Estepa R, Junne S, Neubauer P.	Bioengineering (Basel)	10.3390/bioengineering8080103	2021
	Exploring and expanding the natural chemical space of bacterial diterpenes.	Wei X, Ning W, McCadden CA, Alsup TA, Li Z, Lomowska-Keehner DP, Nafie J, Qu T, Opoku MO, Gillia GR, Xu B, Icenhour DG, Rudolf JD.	Nat Commun	10.1038/s41467-025-57145-6	2025
Metabolism	Engineering the TetR-family transcriptional regulator XNR_0706 to enhance heterologous spinosad production in Streptomyces albus B4 chassis.	Cui X, Tang H, Wang W, Wei W, Wu J, Ye BC.	Synth Syst Biotechnol	10.1016/j.synbio.2024.08.008	2025
Enzymology	Production of Whole-Cell Lipase from Streptomyces clavuligerus in a Bench-Scale Bioreactor and Its First Evaluation as Biocatalyst for Synthesis in Organic Medium.	Dos Santos JBC, da Silva Cruz RG, Tardioli PW.	Appl Biochem Biotechnol	10.1007/s12010-017-2440-5	2017
Genetics	Whole Genome Analysis and Assessment of the Metabolic Potential of Streptomyces carpaticus SCPM-O-B-9993, a Promising Phytostimulant and Antiviral Agent	Bataeva Y, Delegan Y, Bogun A, Shishkina L, Grigoryan L.	Biology (Basel)		2024
	Understanding the competing pathways leading to hydropyrene and isoelisabethatriene.	Zev S, Ringel M, Driller R, Loll B, Bruck T, Major DT.	Beilstein J Org Chem	10.3762/bjoc.18.97	2022
	Bibliometric Analysis of Global Research on Clavulanic Acid.	Ramirez-Malule H.	Antibiotics (Basel)	10.3390/antibiotics7040102	2018
	Methodology for awakening the potential secondary metabolic capacity in actinomycetes.	Saito S, Arai MA.	Beilstein J Org Chem	10.3762/bjoc.20.69	2024
Genetics	A metagenomic catalog for exploring the plastizymes landscape covering taxa, genes, and proteins.	Jahanshahi DA, Ariaeenejad S, Kavousi K.	Sci Rep	10.1038/s41598-023-43042-9	2023
	Discovery of Novel Tyrosine Ammonia Lyases for the Enzymatic Synthesis of p-Coumaric Acid.	Brack Y, Sun C, Yi D, Bornscheuer UT.	Chembiochem	10.1002/cbic.202200062	2022
Metabolism	Proteomics analysis of global regulatory cascades involved in clavulanic acid production and morphological development in Streptomyces clavuligerus.	Ferguson NL, Pena-Castillo L, Moore MA, Bignell DR, Tahlan K.	J Ind Microbiol Biotechnol	10.1007/s10295-016-1733-y	2016
Metabolism	[Semi-in vitro biosynthesis of cryptic lanthipeptide CLA 124 from Streptomyces clavuligerus].	Zhang Z, Zhang L, Zhang J, Ma H, Sun S, Zhong J.	Wei Sheng Wu Xue Bao		2015
Pathogenicity	Dissociation of cephamycin C and clavulanic acid biosynthesis by 1,3-diaminopropane in Streptomyces clavuligerus.	Leite CA, Cavallieri AP, Baptista AS, Araujo ML.	FEMS Microbiol Lett	10.1093/femsle/fnv215	2016
Metabolism	An improved HPLC-DAD method for clavulanic acid quantification in fermentation broths of Streptomyces clavuligerus.	Ramirez-Malule H, Junne S, Lopez C, Zapata J, Saez A, Neubauer P, Rios-Estepa R.	J Pharm Biomed Anal	10.1016/j.jpba.2015.12.035	2016
	Agri-Food and Food Waste Lignocellulosic Materials for Lipase Immobilization as a Sustainable Source of Enzyme Support-A Comparative Study.	Zieniuk B, Malajowicz J, Jasinska K, Wierzchowska K, Ugur S, Fabiszewska A.	Foods	10.3390/foods13233759	2024
Genetics	Genome sequence data of Streptomyces sp. SS52, an endophytic strain for daidzein biosynthesis.	Nguyen HV, Truong PM, Duong HT, Dinh HM, Nguyen CH.	Data Brief	10.1016/j.dib.2019.104746	2019
	Development of a beta-lactamase-based aggregation-induced emission lateral flow strip for the detection of clavulanic acid in Milk.	Wang X, He T, Dou L, Ma L, Yu X, Wang Z, Wen K.	Food Chem X	10.1016/j.fochx.2024.101950	2024
Metabolism	Flux balance analysis in the production of clavulanic acid by Streptomyces clavuligerus.	Sanchez C, Quintero JC, Ochoa S.	Biotechnol Prog	10.1002/btpr.2132	2015
	Development and validation of a high-performance thin layer chromatography method for the simultaneous determination of amoxicillin and clavulanic acid combinations in tablet dosage forms.	Asres E, Layloff T, Ashenef A.	Heliyon	10.1016/j.heliyon.2023.e22891	2023
Metabolism	A Genome-Scale Insight into the Effect of Shear Stress During the Fed-Batch Production of Clavulanic Acid by Streptomyces Clavuligerus.	Gomez-Rios D, Lopez-Agudelo VA, Ramirez-Malule H, Neubauer P, Junne S, Ochoa S, Rios-Estepa R.	Microorganisms	10.3390/microorganisms8091255	2020
Enzymology	Patulin Detoxification by Evolutionarily Divergent Reductases of Gluconobacter oxydans ATCC 621.	Abraham N, Chan E, Li XZ, Zhu H, Mats L, Zhou T, Seah SYK.	J Agric Food Chem	10.1021/acs.jafc.4c12572	2025
	Penicillin-Binding Proteins, beta-Lactamases, and beta-Lactamase Inhibitors in beta-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms.	Martin JF, Alvarez-Alvarez R, Liras P.	Int J Mol Sci	10.3390/ijms23105662	2022
Enzymology	Functional characterisation of twelve terpene synthases from actinobacteria.	Chhalodia AK, Xu H, Tabekoueng GB, Gu B, Taizoumbe KA, Lauterbach L, Dickschat JS.	Beilstein J Org Chem	10.3762/bjoc.19.100	2023
	Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook.	Qiu S, Yang A, Zeng H.	PLoS Comput Biol	10.1371/journal.pcbi.1011391	2023
	Reflecting on Fleming's caveat: the impact of stakeholder decision-making on antimicrobial resistance evolution.	Ashfield T, Cooray M, Jimenez-Acha I, Riaz Z, Gifford DR, Lagator M.	Microbiology (Reading)	10.1099/mic.0.001534	2025
Genetics	Distribution and comparative genomic analysis of antimicrobial gene clusters found in Pantoea.	Kirk A, Stavrinides J.	Front Microbiol	10.3389/fmicb.2024.1416674	2024
	Occurrence of Virulence Genes among Methicillin-Resistant Staphylococcus aureus Isolated from Subclinical Bovine Mastitis.	Shahid M, Hussain R, Nawaz Z, Aslam B, Ahmad MZ, Siddique AB, Ahsan H, Fatima A, Khan I, Mustafa B, Iqbal R, Al Syaad KM, Shami A.	ACS Omega	10.1021/acsomega.3c04206	2023
	Mycobacterium tuberculosis beta-lactamase variant reduces sensitivity to ampicillin/avibactam in a zebrafish-Mycobacterium marinum model of tuberculosis.	van Alen I, Aguirre Garcia MA, Maaskant JJ, Kuijl CP, Bitter W, Meijer AH, Ubbink M.	Sci Rep	10.1038/s41598-023-42152-8	2023
Metabolism	Improvement of 7alpha-methoxycephalosporins production by overexpression of cmcJ and cmcI controlled by promoter ermEp* in Streptomyces clavuligerus.	Shao L, Huang JJ, Yu Y, Li MX, Pu T, Kan SD, Chen DJ.	J Appl Microbiol	10.1111/jam.12640	2014
	A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus.	Horbal L, Ostash B, Luzhetskyy A, Walker S, Kalinowski J, Fedorenko V.	Appl Microbiol Biotechnol	10.1007/s00253-016-7685-3	2016
Metabolism	Isopentenol Utilization Pathway for the Production of Linalool in Escherichia coli Using an Improved Bacterial Linalool/Nerolidol Synthase.	Ferraz CA, Leferink NGH, Kosov I, Scrutton NS.	Chembiochem	10.1002/cbic.202100110	2021
	The impact of selected xanthophylls on oil hydrolysis by pancreatic lipase: in silico and in vitro studies.	Dabrowski G, Czaplicki S, Szustak M, Korkus E, Gendaszewska-Darmach E, Konopka I.	Sci Rep	10.1038/s41598-024-53312-9	2024
Pathogenicity	Green synthesis of bacterial mediated anti-proliferative gold nanoparticles: inducing mitotic arrest (G2/M phase) and apoptosis (intrinsic pathway).	Kumar CG, Poornachandra Y, Chandrasekhar C.	Nanoscale	10.1039/c5nr04577k	2015
	Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases.	Leferink NGH, Escorcia AM, Ouwersloot BR, Johanissen LO, Hay S, van der Kamp MW, Scrutton NS.	Chembiochem	10.1002/cbic.202100688	2022
	Neurospora sp. Mediated Synthesis of Naringenin for the Production of Bioactive Nanomaterials.	Salunkhe JD, Pulidindi IN, Patil VS, Patil SV.	Bioengineering (Basel)	10.3390/bioengineering11050510	2024
Enzymology	Identification of an unusual type II thioesterase in the dithiolopyrrolone antibiotics biosynthetic pathway.	Zhai Y, Bai S, Liu J, Yang L, Han L, Huang X, He J.	Biochem Biophys Res Commun	10.1016/j.bbrc.2016.03.105	2016
Biotechnology	[Improvement of natamycin production in an industrial strain by heterologous expression of the afsRS(cla) global regulatory genes].	Tao Z, Wang Y, Zheng H, Tao M.	Sheng Wu Gong Cheng Xue Bao		2015
	Overproduction of clavulanic acid by extractive fermentation	Costa CLL, Badino AC.	Electron J Biotechnol	10.1016/j.ejbt.2015.03.001	2015
	Robustifying Experimental Tracer Design for13C-Metabolic Flux Analysis.	Beyss M, Parra-Pena VD, Ramirez-Malule H, Noh K.	Front Bioeng Biotechnol	10.3389/fbioe.2021.685323	2021
	Deciphering the Role of beta-Lactamase Inhibitors, Membrane Permeabilizers and Efflux Pump Inhibitors as Emerging Targets in Antibiotic Resistance.	Mhapankar N, Siddique A, Doshi G, Godad A, Zine S.	Indian J Microbiol	10.1007/s12088-022-01045-6	2022
Metabolism	A 1.8-Mb-reduced Streptomyces clavuligerus genome: relevance for secondary metabolism and differentiation.	Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Robles-Reglero V, Santamarta I, Perez-Redondo R, Martin JF, Liras P.	Appl Microbiol Biotechnol	10.1007/s00253-013-5382-z	2014
	Enhanced triacylglycerol metabolism contributes to the efficient biosynthesis of spinosad in Saccharopolyspora spinosa.	Cao L, Liu Y, Sun L, Zhu Z, Yang D, Xia Z, Jin D, Dai Z, Rang J, Xia L.	Synth Syst Biotechnol	10.1016/j.synbio.2024.06.007	2024
	Characterization of the Metabolic Response of Streptomyces clavuligerus to Shear Stress in Stirred Tanks and Single-Use 2D Rocking Motion Bioreactors for Clavulanic Acid Production.	Gomez-Rios D, Junne S, Neubauer P, Ochoa S, Rios-Estepa R, Ramirez-Malule H.	Antibiotics (Basel)	10.3390/antibiotics8040168	2019
	Gliotoxin and related metabolites as zinc chelators: implications and exploitation to overcome antimicrobial resistance.	Downes SG, Doyle S, Jones GW, Owens RA.	Essays Biochem	10.1042/ebc20220222	2023
Metabolism	Clavulanic acid production estimation based on color and structural features of Streptomyces clavuligerus bacteria using self-organizing map and genetic algorithm.	Nurmohamadi M, Pourghassem H.	Comput Methods Programs Biomed	10.1016/j.cmpb.2014.02.013	2014
Metabolism	Penicillin-binding proteins in Actinobacteria.	Ogawara H.	J Antibiot (Tokyo)	10.1038/ja.2014.148	2015
	A Cysteine-Reloading Process Initiating the Biosynthesis of the Bicyclic Scaffold of Dithiolopyrrolones.	Chen Y, Tu Y, Pan T, Deng Z, Duan L.	Antibiotics (Basel)	10.3390/antibiotics12040787	2023
Metabolism	Clavulanic acid production by Streptomyces clavuligerus: biogenesis, regulation and strain improvement.	Paradkar A.	J Antibiot (Tokyo)	10.1038/ja.2013.26	2013
	Improvement of clavulanic acid production by Streptomyces clavuligerus with peanut derivatives	Hamedi J, Imanparast F, Tirandaz H, Laamerad B, Sadrai S.	Ann Microbiol	10.1007/s13213-011-0365-8	2012
	Inversion of the stereochemical configuration (3S, 5S)-clavaminic acid into (3R, 5R)-clavulanic acid: A computationally-assisted approach based on experimental evidence.	Ramirez-Malule H, Restrepo A, Cardona W, Junne S, Neubauer P, Rios-Estepa R.	J Theor Biol	10.1016/j.jtbi.2016.01.028	2016
	Isolation and screening of Streptomyces sp. Al-Dhabi-49 from the environment of Saudi Arabia with concomitant production of lipase and protease in submerged fermentation.	Al-Dhabi NA, Esmail GA, Ghilan AM, Arasu MV.	Saudi J Biol Sci	10.1016/j.sjbs.2019.11.011	2020
	A comparison of the clavam biosynthetic gene clusters in Streptomyces antibioticus Tü1718 and Streptomyces clavuligerus.	Goomeshi Nobary S, Jensen SE.	Can J Microbiol	10.1139/w2012-012	2012
Phylogeny	Characterization of natural therapeutic compounds producing novel bacterial strains isolated from Hyderabad, India.	Bhrdwaj A, Nayarisseri A, Singh SK.	Sci Rep	10.1038/s41598-025-11615-5	2025
	Novel transcription and replication-competent virus-like particles system modelling the Nipah virus life cycle.	Wang Y, Fan L, Ye P, Wang Z, Liang C, Liu Q, Yang X, Long Z, Shi W, Zhou Y, Lin J, Yan H, Huang H, Liu L, Qian J.	Emerg Microbes Infect	10.1080/22221751.2024.2368217	2024
	Three new LmbU targets outside lmb cluster inhibit lincomycin biosynthesis in Streptomyces lincolnensis.	Mao Y, Zhang X, Zhou T, Hou B, Ye J, Wu H, Wang R, Zhang H.	Microb Cell Fact	10.1186/s12934-023-02284-y	2024
	Strategies to combat Gram-negative bacterial resistance to conventional antibacterial drugs: a review.	Bhowmik P, Modi B, Roy P, Chowdhury A.	Osong Public Health Res Perspect	10.24171/j.phrp.2022.0323	2023
	Comparative Molecular Mechanisms of Biosynthesis of Naringenin and Related Chalcones in Actinobacteria and Plants: Relevance for the Obtention of Potent Bioactive Metabolites.	Martin JF, Liras P.	Antibiotics (Basel)	10.3390/antibiotics11010082	2022
Pathogenicity	N-linked glycoproteins and host proteases are involved in swine acute diarrhea syndrome coronavirus entry.	Chen Y, Liu X, Zheng J-N, Yang L-J, Luo Y, Yao Y-L, Liu M-Q, Xie T-t, Lin H-F, He Y-T, Zhou P, Hu B, Tian R-J, Shi Z-L.	J Virol	10.1128/jvi.00916-23	2023
	Characterization of the antibacterial activity from ethanolic extracts of the botanical, Larrea tridentata.	Turner T, Ruiz G, Gerstel J, Langland J.	BMC Complement Med Ther	10.1186/s12906-021-03344-9	2021
	Identification of two putative acyltransferase genes potentially implicated in dithiolopyrrolone biosyntheses in Saccharothrix algeriensis NRRL B-24137.	Saker S, Lebrihi A, Mathieu F.	Appl Biochem Biotechnol	10.1007/s12010-014-0896-0	2014
Metabolism	New strategy of site-directed mutagenesis identifies new sites to improve Streptomyces clavuligerus deacetoxycephalosporin C synthase activity toward penicillin G.	Ji J, Tian X, Fan K, Yang K.	Appl Microbiol Biotechnol	10.1007/s00253-011-3566-y	2012
Metabolism	Role of the cmcH-ccaR intergenic region and ccaR overexpression in cephamycin C biosynthesis in Streptomyces clavuligerus.	Kurt A, Alvarez-Alvarez R, Liras P, Ozcengiz G.	Appl Microbiol Biotechnol	10.1007/s00253-013-4721-4	2013
	Enhancing the activity of beta-lactamase inhibitory protein-II with cell-penetrating peptide against KPC-2-carrying Klebsiella pneumoniae.	Chatupheeraphat C, Peamchai J, Kaewsai N, Anuwongcharoen N, Eiamphungporn W.	PLoS One	10.1371/journal.pone.0296727	2024
Metabolism	Shear conditions in clavulanic acid production by Streptomyces clavuligerus in stirred tank and airlift bioreactors.	Cerri MO, Badino AC.	Bioprocess Biosyst Eng	10.1007/s00449-012-0682-8	2012
Metabolism	Bioinformatics-aided identification, characterization and applications of mushroom linalool synthases.	Zhang C, Chen X, Lee RTC, T R, Maurer-Stroh S, Ruhl M.	Commun Biol	10.1038/s42003-021-01715-z	2021
	Characterization of Pathway-Specific Regulator NigR for High Yield Production of Nigericin in Streptomyces malaysiensis F913.	Wei J, Ma M, Guo S, Xu Y, Xie J, Pan G, Zhou Z.	Antibiotics (Basel)	10.3390/antibiotics11070938	2022
Phylogeny	16S rRNA phylogeny and clustering is not a reliable proxy for genome-based taxonomy in Streptomyces.	Kiepas AB, Hoskisson PA, Pritchard L.	Microb Genom	10.1099/mgen.0.001287	2024
	Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes	Jnawali HN, Yoo JC, Sohng JK.	Biotechnol Lett		2011
	A Multidisciplinary Approach to Unraveling the Natural Product Biosynthetic Potential of a Streptomyces Strain Collection Isolated from Leaf-Cutting Ants.	Ceniceros A, Cuervo L, Mendez C, Salas JA, Olano C, Malmierca MG.	Microorganisms	10.3390/microorganisms9112225	2021
Enzymology	Kinetic study on cephamycin C degradation.	Brites LM, Oliveira LM, Barboza M.	Appl Biochem Biotechnol	10.1007/s12010-013-0502-x	2013
	A Burkholderia cenocepacia-like environmental isolate strongly inhibits the plant fungal pathogen Zymoseptoria tritici.	Song T, Gupta S, Sorokin Y, Frenkel O, Cytryn E, Friedman J.	Appl Environ Microbiol	10.1128/aem.02222-23	2024
	Computational design of an imine reductase: mechanism-guided stereoselectivity reversion and interface stabilization.	Wu K, Yan J, Liu Q, Wang X, Wu P, Cao Y, Lu X, Xu Y, Huang J, Shao L.	Chem Sci	10.1039/d3sc04636b	2024
Metabolism	Biosynthesis of clavam metabolites.	Jensen SE.	J Ind Microbiol Biotechnol	10.1007/s10295-012-1191-0	2012
Metabolism	A simplified diphenylamine colorimetric method for growth quantification.	Zhao Y, Xiang S, Dai X, Yang K.	Appl Microbiol Biotechnol	10.1007/s00253-013-4893-y	2013
Metabolism	Improvement of clavulanic acid production in Streptomyces clavuligerus by genetic manipulation of structural biosynthesis genes.	Jnawali HN, Yoo JC, Sohng JK.	Biotechnol Lett	10.1007/s10529-011-0561-4	2011
Enzymology	Glutamate dehydrogenase from Pantoea ananatis: A new bacterial enzyme with dual coenzyme specificity.	Kharchenko MS, Skripnikova VS, Rostova JG, Zakataeva NP.	PLoS One	10.1371/journal.pone.0328289	2025
Enzymology	Global Metabolomics Discovers Two Novel Biomarkers in Pyridoxine-Dependent Epilepsy Caused by ALDH7A1 Deficiency.	Bohm HO, Yazdani M, Sandas EM, Osteby Vassli A, Kristensen E, Rootwelt H, Skogvold HB, Brodtkorb E, Elgstoen KBP.	Int J Mol Sci	10.3390/ijms232416061	2022
Metabolism	Expression of cefF significantly decreased deacetoxycephalosporin C formation during cephalosporin C production in Acremonium chrysogenum.	An Y, Dong H, Liu G.	J Ind Microbiol Biotechnol	10.1007/s10295-011-1025-5	2012
Phylogeny	SYNBIP: synthetic binding proteins for research, diagnosis and therapy.	Wang X, Li F, Qiu W, Xu B, Li Y, Lian X, Yu H, Zhang Z, Wang J, Li Z, Xue W, Zhu F.	Nucleic Acids Res	10.1093/nar/gkab926	2022
Metabolism	Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.	Alvarez-Alvarez R, Martinez-Burgo Y, Perez-Redondo R, Brana AF, Martin JF, Liras P.	Appl Microbiol Biotechnol	10.1007/s00253-013-5148-7	2013
	Stereochemical investigations on the biosynthesis of achiral (Z)-gamma-bisabolene in Cryptosporangium arvum.	Rinkel J, Dickschat JS.	Beilstein J Org Chem	10.3762/bjoc.15.75	2019
	Production and characterization of an organic solvent activated protease from haloalkaliphilic bacterium Halobiforma sp. strain BNMIITR.	Gupta M, Choudhury B, Navani NK.	Heliyon	10.1016/j.heliyon.2024.e25084	2024
Metabolism	Overexpression of human antiquitin in E. coli: enzymatic characterization of twelve ALDH7A1 missense mutations associated with pyridoxine-dependent epilepsy.	Coulter-Mackie MB, Li A, Lian Q, Struys E, Stockler S, Waters PJ.	Mol Genet Metab	10.1016/j.ymgme.2012.06.008	2012
	Data of clavulanic acid and clavulanate-imidazole stability at low temperatures.	Gomez-Rios D, Ramirez-Malule H, Neubauer P, Junne S, Rios-Estepa R.	Data Brief	10.1016/j.dib.2019.103775	2019
	Morphological differentiation and clavulanic acid formation are affected in a Streptomyces clavuligerus adpA-deleted mutant.	Lopez-Garcia MT, Santamarta I, Liras P.	Microbiology (Reading)	10.1099/mic.0.035956-0	2010
Genetics	Genome-scale determination of 5´ and 3´ boundaries of RNA transcripts in Streptomyces genomes.	Lee Y, Lee N, Hwang S, Kim W, Jeong Y, Cho S, Palsson BO, Cho BK.	Sci Data	10.1038/s41597-020-00775-w	2020
	Making Enzymes Suitable for Organic Chemistry by Rational Protein Design.	Reetz M.	Chembiochem	10.1002/cbic.202200049	2022
	Convergent evolution in toxin detection and resistance provides evidence for conserved bacterial-fungal interactions.	Dolan SK, Duong AT, Whiteley M.	Proc Natl Acad Sci U S A	10.1073/pnas.2304382121	2024
Genetics	Streptomyces venezuelae NRRL B-65442: genome sequence of a model strain used to study morphological differentiation in filamentous actinobacteria.	Gomez-Escribano JP, Holmes NA, Schlimpert S, Bibb MJ, Chandra G, Wilkinson B, Buttner MJ, Bibb MJ.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab035	2021
	Total enzymatic synthesis of cis-alpha-irone from a simple carbon source.	Chen X, T R, Esque J, Zhang C, Shukal S, Lim CC, Ong L, Smith D, Andre I.	Nat Commun	10.1038/s41467-022-35232-2	2022
Biotechnology	Proteome-wide alterations in an industrial clavulanic acid producing strain of Streptomyces clavuligerus.	Unsaldi E, Kurt-Kizildogan A, Voigt B, Becher D, Ozcengiz G.	Synth Syst Biotechnol	10.1016/j.synbio.2016.10.003	2017
	Streptomyces albidoflavus Q antifungal metabolites inhibit the ergosterol biosynthesis pathway and yeast growth in fluconazole-resistant Candida glabrata: phylogenomic and metabolomic analyses.	Bautista-Crescencio C, Casimiro-Ramos A, Fragoso-Vazquez MJ, Correa-Basurto J, Olano C, Hernandez-Rodriguez C, Villa-Tanaca L.	Microbiol Spectr	10.1128/spectrum.01271-23	2023
Metabolism	Development of a colorimetric assay for rapid quantitative measurement of clavulanic acid in microbial samples.	Dai X, Xiang S, Li J, Gao Q, Yang K.	Sci China Life Sci	10.1007/s11427-012-4287-x	2012
Pathogenicity	Inhibition of N-linked Glycosylation by Tunicamycin May Contribute to The Treatment of SARS-CoV-2.	Dawood AA, Altobje MA.	Microb Pathog	10.1016/j.micpath.2020.104586	2020
Metabolism	Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene.	Blank PN, Pemberton TA, Chow JY, Poulter CD, Christianson DW.	Biochemistry	10.1021/acs.biochem.8b00899	2018
Metabolism	Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus.	Xiang SH, Li J, Yin H, Zheng JT, Yang X, Wang HB, Luo JL, Bai H, Yang KQ.	Metab Eng	10.1016/j.ymben.2009.06.003	2009
	Single-cell RNA-Seq reveals intracellular microbial diversity within immune cells during SARS-CoV-2 infection and recovery.	Yadav S, Mehta P, Soni J, Chattopadhyay P, Devi P, Habyarimana T, Tardalkar K, Joshi M, Pandey R.	iScience	10.1016/j.isci.2023.108357	2023
Metabolism	A novel finding that Streptomyces clavuligerus can produce the antibiotic clavulanic acid using olive oil as a sole carbon source.	Efthimiou G, Thumser AE, Avignone-Rossa CA.	J Appl Microbiol	10.1111/j.1365-2672.2008.03975.x	2008
	Bacterial-type ferroxidase tunes iron-dependent phosphate sensing during Arabidopsis root development.	Naumann C, Heisters M, Brandt W, Janitza P, Alfs C, Tang N, Toto Nienguesso A, Ziegler J, Imre R, Mechtler K, Dagdas Y, Hoehenwarter W, Sawers G, Quint M, Abel S.	Curr Biol	10.1016/j.cub.2022.04.005	2022
Enzymology	Preliminary studies for cephamycin C purification technique.	Neto Ade B, Bustamante MC, Oliveira JH, Granato AC, Bellao C, Badino AC, Barboza M, Hokka CO.	Appl Biochem Biotechnol	10.1007/s12010-011-9417-6	2012
Genetics	Discovery of novel secondary metabolites encoded in actinomycete genomes through coculture.	Kim JH, Lee N, Hwang S, Kim W, Lee Y, Cho S, Palsson BO, Cho BK.	J Ind Microbiol Biotechnol	10.1093/jimb/kuaa001	2021
	Regulatory mechanisms controlling antibiotic production in Streptomyces clavuligerus.	Liras P, Gomez-Escribano JP, Santamarta I.	J Ind Microbiol Biotechnol	10.1007/s10295-008-0351-8	2008
	Metatranscriptomic insights into the dengue patient blood microbiome: Enhanced microbial diversity and metabolic activity in severe patients.	Yadav A, Devi P, Kumari P, Shamim U, Tarai B, Budhiraja S, Pandey R.	PLoS Negl Trop Dis	10.1371/journal.pntd.0012589	2024
Metabolism	Liquid chromatography-mass spectrometry characterization of FK506 biosynthetic intermediates in Streptomyces clavuligerus KCTC 10561BP.	Park JW, Mo SJ, Park SR, Ban YH, Yoo YJ, Yoon YJ.	Anal Biochem	10.1016/j.ab.2009.06.021	2009
Enzymology	Degradation Kinetics of Clavulanic Acid in Fermentation Broths at Low Temperatures.	Gomez-Rios D, Ramirez-Malule H, Neubauer P, Junne S, Rios-Estepa R.	Antibiotics (Basel)	10.3390/antibiotics8010006	2019
	Clavulanic acid biosynthesis and genetic manipulation for its overproduction.	Song JY, Jensen SE, Lee KJ.	Appl Microbiol Biotechnol	10.1007/s00253-010-2801-2	2010
Pathogenicity	Organic solvent tolerance of an alkaline protease from salt-tolerant alkaliphilic Streptomyces clavuligerus strain Mit-1.	Thumar JT, Singh SP.	J Ind Microbiol Biotechnol	10.1007/s10295-008-0487-6	2009
Metabolism	Enhanced FK506 production in Streptomyces clavuligerus CKD1119 by engineering the supply of methylmalonyl-CoA precursor.	Mo S, Ban YH, Park JW, Yoo YJ, Yoon YJ.	J Ind Microbiol Biotechnol	10.1007/s10295-009-0635-7	2009
Pathogenicity	High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus.	Brethauer S, Held M, Panke S.	Biotechnol Bioeng	10.1002/bit.21783	2008
Metabolism	Mycobacterial MMAR_2193 catalyzes O-methylation of diverse polyketide cores.	Giri GR, Saxena P.	PLoS One	10.1371/journal.pone.0262241	2022
Enzymology	Immobilization of Streptomyces clavuligerus on loofah sponge for the production of clavulanic acid.	Saudagar PS, Shaligram NS, Singhal RS.	Bioresour Technol	10.1016/j.biortech.2007.05.004	2008
Proteome	Influence of Amino Acid Feeding on Production of Calcimycin and Analogs in Streptomyces chartreusis.	Arend KI, Bandow JE.	Int J Environ Res Public Health	10.3390/ijerph18168740	2021
Metabolism	Directed evolution and rational approaches to improving Streptomyces clavuligerus deacetoxycephalosporin C synthase for cephalosporin production.	Goo KS, Chua CS, Sim TS.	J Ind Microbiol Biotechnol	10.1007/s10295-009-0549-4	2009
Metabolism	Production of cephamycin C by Streptomyces clavuligerus NT4 using solid-state fermentation.	Bussari B, Saudagar PS, Shaligram NS, Survase SA, Singhal RS.	J Ind Microbiol Biotechnol	10.1007/s10295-007-0265-x	2008
Metabolism	Average shear rate in three pneumatic bioreactors.	Thomasi SS, Cerri MO, Badino AC.	Bioprocess Biosyst Eng	10.1007/s00449-010-0422-x	2010
	Clavulanic Acid: A Novel Potential Agent in Prevention and Treatment of Scopolamine-Induced Alzheimer's Disease.	Anoush M, Pourmansouri Z, Javadi R, GhorbanPour B, Sharafi A, Mohamadpour H, Jafari Anarkooli I, Andalib S.	ACS Omega	10.1021/acsomega.2c00231	2022
	Small molecule inducers of actinobacteria natural product biosynthesis.	Alwali AY, Parkinson EI.	J Ind Microbiol Biotechnol	10.1093/jimb/kuad019	2023
	Synthesis of eunicellane-type bicycles embedding a 1,3-cyclohexadiene moiety.	Frichert A, Jones PG, Lindel T.	Beilstein J Org Chem	10.3762/bjoc.14.222	2018
Enzymology	Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.	Gomez-Escribano JP, Martin JF, Hesketh A, Bibb MJ, Liras P.	Microbiology (Reading)	10.1099/mic.0.2007/011890-0	2008
	Photoaffinity Capture Compounds to Profile the Magic Spot Nucleotide Interactomes.	Haas TM, Laventie BJ, Lagies S, Harter C, Prucker I, Ritz D, Saleem-Batcha R, Qiu D, Huttel W, Andexer J, Kammerer B, Jenal U, Jessen HJ.	Angew Chem Int Ed Engl	10.1002/anie.202201731	2022
	Enhancing the Antibiotic Production by Thermophilic Bacteria Isolated from Hot Spring Waters via Ethyl Methanesulfonate Mutagenesis.	Kortam YG, Abd El-Rahim WM, Khattab AEA, Rebouh NY, Gurina RR, Barakat OS, Zakaria M, Moawad H.	Antibiotics (Basel)	10.3390/antibiotics12071095	2023
	New insights into the disulfide bond formation enzymes in epidithiodiketopiperazine alkaloids.	Liu H, Fan J, Zhang P, Hu Y, Liu X, Li SM, Yin WB.	Chem Sci	10.1039/d0sc06647h	2021
Enzymology	Two-step purification of a highly thermostable alkaline protease from salt-tolerant alkaliphilic Streptomyces clavuligerus strain Mit-1.	Thumar J, Singh SP.	J Chromatogr B Analyt Technol Biomed Life Sci	10.1016/j.jchromb.2007.04.023	2007
Enzymology	A complete library of amino acid alterations at R306 in Streptomyces clavuligerus deacetoxycephalosporin C synthase demonstrates its structural role in the ring-expansion activity.	Sim Goo K, Song Chua C, Sim TS.	Proteins	10.1002/prot.21549	2008
	An Unusual Oxidative Rearrangement Catalyzed by a Divergent Member of the 2-Oxoglutarate-Dependent Dioxygenase Superfamily during Biosynthesis of Dehydrofosmidomycin.	Parkinson EI, Lakkis HG, Alwali AA, Metcalf MEM, Modi R, Metcalf WW.	Angew Chem Int Ed Engl	10.1002/anie.202206173	2022
Pathogenicity	Aneuploidy Underlies Tolerance and Cross-Tolerance to Drugs in Candida parapsilosis.	Yang F, Lu H, Wu H, Fang T, Berman J, Jiang YY.	Microbiol Spectr	10.1128/spectrum.00508-21	2021
Metabolism	Optimization of nutritional requirements and feeding strategies for clavulanic acid production by Streptomyces clavuligerus.	Saudagar PS, Singhal RS.	Bioresour Technol	10.1016/j.biortech.2006.08.003	2007
Metabolism	Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid.	Zhu C, Xu B, Adpressa DA, Rudolf JD, Loesgen S.	Angew Chem Int Ed Engl	10.1002/anie.202102453	2021
Enzymology	Synthesis of 1-piperideine-6-carboxylic acid produced by L-lysine-epsilon-aminotransferase from the Streptomyces clavuligerus gene expressed in Escherichia coli.	Wu ML, Chen JH, Ho CT, Huang TC.	J Agric Food Chem	10.1021/jf062975u	2007
Metabolism	5S clavam biosynthetic genes are located in both the clavam and paralog gene clusters in Streptomyces clavuligerus.	Tahlan K, Anders C, Wong A, Mosher RH, Beatty PH, Brumlik MJ, Griffin A, Hughes C, Griffin J, Barton B, Jensen SE.	Chem Biol	10.1016/j.chembiol.2006.11.012	2007
	Effect of amino acids on the repression of alkaline protease synthesis in haloalkaliphilic Nocardiopsis dassonvillei.	Sharma AK, Singh SP.	Biotechnol Rep (Amst)	10.1016/j.btre.2016.10.004	2016
	Enhancement of linalool production in Saccharomyces cerevisiae by utilizing isopentenol utilization pathway.	Zhang Y, Cao X, Wang J, Tang F.	Microb Cell Fact	10.1186/s12934-022-01934-x	2022
	Use of the native flp gene to generate in-frame unmarked mutations in Streptomyces spp.	Zelyas N, Tahlan K, Jensen SE.	Gene	10.1016/j.gene.2009.03.022	2009
	Clavulanic acid: a review.	Saudagar PS, Survase SA, Singhal RS.	Biotechnol Adv	10.1016/j.biotechadv.2008.03.002	2008
	Chemical and transcriptomic analyses of leaf trichomes from Cistus creticus subsp. creticus reveal the biosynthetic pathways of certain labdane-type diterpenoids and their acetylated forms.	Papanikolaou AS, Papaefthimiou D, Matekalo D, Karakousi CV, Makris AM, Kanellis AK.	J Exp Bot	10.1093/jxb/erae098	2024
	Prospects for Antibacterial Discovery and Development.	Privalsky TM, Soohoo AM, Wang J, Walsh CT, Wright GD, Gordon EM, Gray NS, Khosla C.	J Am Chem Soc	10.1021/jacs.1c10200	2021
Metabolism	Rational strain improvement for enhanced clavulanic acid production by genetic engineering of the glycolytic pathway in Streptomyces clavuligerus.	Li R, Townsend CA.	Metab Eng	10.1016/j.ymben.2006.01.003	2006
Enzymology	Structural and mechanistic studies on N(2)-(2-carboxyethyl)arginine synthase.	Caines ME, Sorensen JL, Schofield CJ.	Biochem Biophys Res Commun	10.1016/j.bbrc.2009.05.095	2009
Enzymology	The molecular structure of ornithine acetyltransferase from Mycobacterium tuberculosis bound to ornithine, a competitive inhibitor.	Sankaranarayanan R, Cherney MM, Garen C, Garen G, Niu C, Yuan M, James MN.	J Mol Biol	10.1016/j.jmb.2010.02.018	2010
Metabolism	Evaluation of the effects of the parameters involved in the purification of clavulanic acid from fermentation broth by aqueous two-phase systems.	Silva CS, Bovarotti E, Rodrigues MI, Hokka CO, Barboza M.	Bioprocess Biosyst Eng	10.1007/s00449-008-0285-6	2009
	Characterization of pbpA and pbp2 encoding penicillin-binding proteins located on the downstream of clavulanic acid gene cluster in Streptomyces clavuligerus.	Ishida K, Hung TV, Liou K, Lee HC, Shin CH, Sohng JK.	Biotechnol Lett	10.1007/s10529-005-6071-5	2006
Metabolism	Using redox potential to detect microbial activities during clavulanic acid biosynthesis in Streptomyces clavuligerus.	Lin YH, Hwang SC, Gong JT, Wu JY, Chen KC.	Biotechnol Lett	10.1007/s10529-005-3727-0	2005
Metabolism	[Effect of lat disruption on clavulanic acid production].	Wang YH, Jing CF, Tao MF, Yang B, Xu AL.	Wei Sheng Wu Xue Bao		2005
Enzymology	Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus.	Chow JY, Tian BX, Ramamoorthy G, Hillerich BS, Seidel RD, Almo SC, Jacobson MP, Poulter CD.	Proc Natl Acad Sci U S A	10.1073/pnas.1505127112	2015
Pathogenicity	Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.	Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Martin JF, Liras P.	Res Microbiol	10.1016/j.resmic.2005.12.008	2006
	Crystal structures of an oligopeptide-binding protein from the biosynthetic pathway of the beta-lactamase inhibitor clavulanic acid.	Mackenzie AK, Valegard K, Iqbal A, Caines ME, Kershaw NJ, Jensen SE, Schofield CJ, Andersson I.	J Mol Biol	10.1016/j.jmb.2009.11.045	2010
	Determination of the average shear rate in a stirred and aerated tank bioreactor.	Campesi A, Cerri MO, Hokka CO, Badino AC.	Bioprocess Biosyst Eng	10.1007/s00449-008-0242-4	2009
Metabolism	Aspects on evolution of fungal beta-lactam biosynthesis gene clusters and recruitment of trans-acting factors.	Brakhage AA, Thon M, Sprote P, Scharf DH, Al-Abdallah Q, Wolke SM, Hortschansky P.	Phytochemistry	10.1016/j.phytochem.2009.09.011	2009
Metabolism	Characterization of sulfhydryl oxidase from Aspergillus tubingensis.	Nivala O, Faccio G, Arvas M, Permi P, Buchert J, Kruus K, Mattinen ML.	BMC Biochem	10.1186/s12858-017-0090-4	2017
Metabolism	Isolation and identification of a novel microorganism producing the immunosuppressant tacrolimus.	Kim HS, Park YI.	J Biosci Bioeng	10.1263/jbb.105.418	2008
	Cell-free synthesis system-assisted pathway bottleneck diagnosis and engineering in Bacillus subtilis.	Tian R, Wang M, Shi J, Qin X, Guo H, Jia X, Li J, Liu L, Du G, Chen J, Liu Y.	Synth Syst Biotechnol	10.1016/j.synbio.2020.06.006	2020
Metabolism	Simultaneous Production of Psilocybin and a Cocktail of beta-Carboline Monoamine Oxidase Inhibitors in "Magic" Mushrooms.	Blei F, Dorner S, Fricke J, Baldeweg F, Trottmann F, Komor A, Meyer F, Hertweck C, Hoffmeister D.	Chemistry	10.1002/chem.201904363	2020
	An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.	Gomez-Escribano JP, Liras P, Pisabarro A, Martin JF.	Mol Microbiol	10.1111/j.1365-2958.2006.05266.x	2006
Metabolism	Discovery of an Unusual Fatty Acid Amide from the ndgRyo Gene Mutant of Marine-Derived Streptomyces youssoufiensis.	Hou J, Liu J, Yang L, Liu Z, Li H, Che Q, Zhu T, Li D, Li W.	Mar Drugs	10.3390/md17010012	2018
Metabolism	Insights into the Mn2+ Binding Site in the Agmatinase-Like Protein (ALP): A Critical Enzyme for the Regulation of Agmatine Levels in Mammals.	Reyes MB, Martinez-Oyanedel J, Navarrete C, Mardones E, Martinez I, Salas M, Lopez V, Garcia-Robles M, Tarifeno-Saldivia E, Figueroa M, Garcia D, Uribe E.	Int J Mol Sci	10.3390/ijms21114132	2020
	Engineering of Penicillium chrysogenum for fermentative production of a novel carbamoylated cephem antibiotic precursor.	Harris DM, Westerlaken I, Schipper D, van der Krogt ZA, Gombert AK, Sutherland J, Raamsdonk LM, van den Berg MA, Bovenberg RA, Pronk JT, Daran JM.	Metab Eng	10.1016/j.ymben.2008.12.003	2009
Pathogenicity	Prevalence, Antimicrobial Resistance Profiles, Virulence and Enterotoxins-Determinant Genes of MRSA Isolated from Subclinical Bovine Mastitis in Egypt.	Algammal AM, Enany ME, El-Tarabili RM, Ghobashy MOI, Helmy YA.	Pathogens	10.3390/pathogens9050362	2020
Metabolism	Expression of the transporter encoded by the cefT gene of Acremonium chrysogenum increases cephalosporin production in Penicillium chrysogenum.	Nijland JG, Kovalchuk A, van den Berg MA, Bovenberg RA, Driessen AJ.	Fungal Genet Biol	10.1016/j.fgb.2008.07.008	2008
	Engineering of Yarrowia lipolytica for the production of plant triterpenoids: Asiatic, madecassic, and arjunolic acids.	Arnesen JA, Belmonte Del Ama A, Jayachandran S, Dahlin J, Rago D, Andersen AJC, Borodina I.	Metab Eng Commun	10.1016/j.mec.2022.e00197	2022
	Bioproduction of Linalool From Paper Mill Waste.	Rinaldi MA, Tait S, Toogood HS, Scrutton NS.	Front Bioeng Biotechnol	10.3389/fbioe.2022.892896	2022
Enzymology	Insights into cephamycin biosynthesis: the crystal structure of CmcI from Streptomyces clavuligerus.	Oster LM, Lester DR, Terwisscha van Scheltinga A, Svenda M, van Lun M, Genereux C, Andersson I.	J Mol Biol	10.1016/j.jmb.2006.02.004	2006
Metabolism	Improved production of germacrene A, a direct precursor of ß-elemene, in engineered Saccharomyces cerevisiae by expressing a cyanobacterial germacrene A synthase.	Zhang W, Guo J, Wang Z, Li Y, Meng X, Shen Y, Liu W.	Microb Cell Fact	10.1186/s12934-020-01500-3	2021
Metabolism	Transcriptional and translational analysis of the ccaR gene from Streptomyces clavuligerus.	Wang L, Tahlan K, Kaziuk TL, Alexander DC, Jensen SE.	Microbiology (Reading)	10.1099/mic.0.27245-0	2004
Metabolism	Three unlinked gene clusters are involved in clavam metabolite biosynthesis in Streptomyces clavuligerus.	Tahlan K, Park HU, Jensen SE.	Can J Microbiol	10.1139/w04-070	2004
Metabolism	Expression, purification, crystallization and preliminary X-ray diffraction studies of the cmcI component of Streptomyces clavuligerus 7alpha-cephem-methoxylase.	Lester DR, Oster LM, Svenda M, Andersson I.	Acta Crystallogr D Biol Crystallogr	10.1107/s090744490401666x	2004
Metabolism	Domoic acid biosynthesis in the red alga Chondria armata suggests a complex evolutionary history for toxin production.	Steele TS, Brunson JK, Maeno Y, Terada R, Allen AE, Yotsu-Yamashita M, Chekan JR, Moore BS.	Proc Natl Acad Sci U S A	10.1073/pnas.2117407119	2022
Metabolism	Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.	Santamarta I, Perez-Redondo R, Lorenzana LM, Martin JF, Liras P.	Mol Microbiol	10.1111/j.1365-2958.2005.04581.x	2005
	Effects of Different beta-Lactam Antibiotics on Indirect Tomato (Solanum lycopersicum L.) Shoot Organogenesis and Agrobacterium tumefaciens Growth Inhibition In Vitro.	Varlamova NV, Dolgikh YI, Blinkov AO, Baranova EN, Khaliluev MR.	Antibiotics (Basel)	10.3390/antibiotics10060660	2021
Metabolism	Dissolution of the Disparate: Co-ordinate Regulation in Antibiotic Biosynthesis.	McLean TC, Wilkinson B, Hutchings MI, Devine R.	Antibiotics (Basel)	10.3390/antibiotics8020083	2019
Genetics	An Unprecedented Number of Cytochrome P450s Are Involved in Secondary Metabolism in Salinispora Species.	Malinga NA, Nzuza N, Padayachee T, Syed PR, Karpoormath R, Gront D, Nelson DR, Syed K.	Microorganisms	10.3390/microorganisms10050871	2022
Pathogenicity	A cylinder-plate method for microbiological assay of clavulanic acid.	Hamedi J, Shahverdi AR, Samadi N, Mohammadi A, Shiran M, Akhondi S.	Pharmeur Sci Notes		2006
Enzymology	Purification and characterization of a dehydrogenase catalyzing conversion of N alpha-benzyloxycarbonyl-L-aminoadipic-delta-semialdehyde to N alpha-benzyloxycarbonyl-L-aminoadipic acid from rhodococcus sp. AIU Z-35-1.	Isobe K, Fukuda N, Nagasawa S.	J Biosci Bioeng	10.1263/jbb.104.398	2007
Biotechnology	Morphology and viability analysis of Streptomyces clavuligerus in industrial cultivation systems.	Pinto LS, Vieira LM, Pons MN, Fonseca MM, Menezes JC.	Bioprocess Biosyst Eng	10.1007/s00449-003-0349-6	2004
Metabolism	Influence of dissolved oxygen and shear conditions on clavulanic acid production by Streptomyces clavuligerus.	Rosa JC, Baptista Neto A, Hokka CO, Badino AC.	Bioprocess Biosyst Eng	10.1007/s00449-004-0386-9	2005
Metabolism	Simultaneous determination of glycerol and clavulanic acid in an antibiotic bioprocess using attenuated total reflectance mid infrared spectroscopy.	Roychoudhury P, McNeil B, Harvey LM.	Anal Chim Acta	10.1016/j.aca.2006.12.051	2007
	Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites.	Liras P, Martin JF.	Antibiotics (Basel)	10.3390/antibiotics12010159	2023
Metabolism	Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation.	Leferink NGH, Ranaghan KE, Battye J, Johannissen LO, Hay S, van der Kamp MW, Mulholland AJ, Scrutton NS.	Chembiochem	10.1002/cbic.201900672	2020
Enzymology	Expression of Chimeric HPV-HIV Protein L1P18 in Pichia pastoris; Purification and Characterization of the Virus-like Particles.	Eto Y, Saubi N, Ferrer P, Joseph-Munne J.	Pharmaceutics	10.3390/pharmaceutics13111967	2021
Metabolism	Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization.	Robin J, Lettier G, McIntyre M, Noorman H, Nielsen J.	Biotechnol Bioeng	10.1002/bit.10677	2003
Genetics	Whole genome sequencing of Streptomyces actuosus ISP-5337, Streptomyces sioyaensis B-5408, and Actinospica acidiphila B-2296 reveals secondary metabolomes with antibiotic potential.	Majer HM, Ehrlich RL, Ahmed A, Earl JP, Ehrlich GD, Beld J.	Biotechnol Rep (Amst)	10.1016/j.btre.2021.e00596	2021
Genetics	Tapping Into Actinobacterial Genomes for Natural Product Discovery.	Singh TA, Passari AK, Jajoo A, Bhasin S, Gupta VK, Hashem A, Alqarawi AA, Abd Allah EF.	Front Microbiol	10.3389/fmicb.2021.655620	2021
	Two relA/spoT homologous genes are involved in the morphological and physiological differentiation of Streptomyces clavuligerus.	Jin W, Ryu YG, Kang SG, Kim SK, Saito N, Ochi K, Lee SH, Lee KJ.	Microbiology (Reading)	10.1099/mic.0.26811-0	2004
Metabolism	Cloning and characterization of a gene encoding the gamma-butyrolactone autoregulator receptor from Streptomyces clavuligerus.	Kim HS, Lee YJ, Lee CK, Choi SU, Yeo SH, Hwang YI, Yu TS, Kinoshita H, Nihira T.	Arch Microbiol	10.1007/s00203-004-0697-x	2004
	A new strategy for the efficient production of pyocyanin, a versatile pigment, in Pseudomonas aeruginosa OG1 via toluene addition.	Ozdal M.	3 Biotech	10.1007/s13205-019-1907-1	2019
Enzymology	An efficient heat-inducible Bacillus subtilis bacteriophage 105 expression and secretion system for the production of the Streptomyces clavuligerus beta-lactamase inhibitory protein (BLIP).	Liu HB, Chui KS, Chan CL, Tsang CW, Leung YC.	J Biotechnol	10.1016/j.jbiotec.2003.12.004	2004
Genetics	On the Origin and Evolutionary Relationships of the Reverse Transcriptases Associated With Type III CRISPR-Cas Systems.	Toro N, Martinez-Abarca F, Gonzalez-Delgado A, Mestre MR.	Front Microbiol	10.3389/fmicb.2018.01317	2018
Metabolism	Advances in engineered microorganisms for improving metabolic conversion via microgravity effects.	Huangfu J, Zhang G, Li J, Li C.	Bioengineered	10.1080/21655979.2015.1056942	2015
Metabolism	Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Kinetics of adipoyl-7-aminodeacetoxycephalosporanic acid and byproduct formations.	Robin J, Bruheim P, Nielsen ML, Noorman H, Nielsen J.	Biotechnol Bioeng	10.1002/bit.10678	2003
Metabolism	Influence of the adipate and dissolved oxygen concentrations on the beta-lactam production during continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus.	Robin J, Bonneau S, Schipper D, Noorman H, Nielsen J.	Metab Eng	10.1016/s1096-7176(03)00006-5	2003
Metabolism	A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.	Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT.	Chembiochem	10.1002/cbic.201200536	2012
Metabolism	C-terminus modification of Streptomyces clavuligerus deacetoxycephalosporin C synthase improves catalysis with an expanded substrate specificity.	Chin HS, Sim TS.	Biochem Biophys Res Commun	10.1016/s0006-291x(02)00629-0	2002
	Bacterial Volatiles (mVOC) Emitted by the Phytopathogen Erwinia amylovora Promote Arabidopsis thaliana Growth and Oxidative Stress.	Parmagnani AS, Kanchiswamy CN, Paponov IA, Bossi S, Malnoy M, Maffei ME.	Antioxidants (Basel)	10.3390/antiox12030600	2023
	Monitoring complex media fermentations with near-infrared spectroscopy: comparison of different variable selection methods.	Ferreira AP, Alves TP, Menezes JC.	Biotechnol Bioeng	10.1002/bit.20526	2005
	A Straightforward Approach to Synthesize 7-Aminocephalosporanic Acid In Vivo in the Cephalosporin C Producer Acremonium chrysogenum.	Lin X, Lambertz J, Dahlmann TA, Nowaczyk MM, Konig B, Kuck U.	J Fungi (Basel)	10.3390/jof8050450	2022
Metabolism	Clavulanic acid degradation in Streptomyces clavuligerus fed-batch cultivations.	Roubos JA, Krabben P, de Laat WT, Babuska R, Heijnen JJ.	Biotechnol Prog	10.1021/bp020294n	2002
Metabolism	Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus.	Lee SD, Park SW, Oh KK, Hong SI, Kim SW.	Lett Appl Microbiol	10.1046/j.1472-765x.2002.01102.x	2002
Metabolism	Mutation of N304 to leucine in Streptomyces clavuligerus deacetoxycephalosporin C synthase creates an enzyme with increased penicillin analogue conversion.	Chin HS, Sim J, Sim TS.	Biochem Biophys Res Commun	10.1006/bbrc.2001.5552	2001
	Exploring the biological application of Penicillium fimorum-derived silver nanoparticles: In vitro physicochemical, antifungal, biofilm inhibitory, antioxidant, anticoagulant, and thrombolytic performance.	Barabadi H, Mobaraki K, Jounaki K, Sadeghian-Abadi S, Vahidi H, Jahani R, Noqani H, Hosseini O, Ashouri F, Amidi S.	Heliyon	10.1016/j.heliyon.2023.e16853	2023
Metabolism	Extracellular production of biologically active deacetoxycephalosporin C synthase from Streptomyces clavuligerus in Pichia pastoris.	Adrio JL, Velasco J, Soler G, Rodriguez-Saiz M, Barredo JL, Moreno MA.	Biotechnol Bioeng	10.1002/bit.10028	2001
	Wastewater from the Edible Oil Industry as a Potential Source of Lipase- and Surfactant-Producing Actinobacteria.	Welz P, Swanepoel G, Weels S, Le Roes-Hill M.	Microorganisms	10.3390/microorganisms9091987	2021
Enzymology	Replacement of tyrosine-197 and the corresponding tyrosine-195 to isoleucine in Cephalosporium acremonium and Streptomyces clavuligerus isopenicillin N synthase.	Loke P, Sim TS.	Z Naturforsch C J Biosci	10.1515/znc-2001-9-1020	2001
Metabolism	The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene.	Mellado E, Lorenzana LM, Rodri Guez-Saiz M, Di Ez B, Liras P, Barredo JL.	Microbiology (Reading)	10.1099/00221287-148-5-1427	2002
Metabolism	Real time monitoring biomass concentration in Streptomyces clavuligerus cultivations with industrial media using a capacitance probe.	Neves AA, Pereira DA, Vieira LM, Menezes JC.	J Biotechnol	10.1016/s0168-1656(00)00325-4	2001
Metabolism	Physiological characterisation of Penicillium chrysogenum strains expressing the expandase gene from Streptomyces clavuligerus during batch cultivations. Growth and adipoyl-7-aminodeacetoxycephalosporanic acid production.	Robin J, Jakobsen M, Beyer M, Noorman H, Nielsen J.	Appl Microbiol Biotechnol	10.1007/s002530100787	2001
	The positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus is mistranslated in a bldA mutant.	Trepanier NK, Jensen SE, Alexander DC, Leskiw BK.	Microbiology (Reading)	10.1099/00221287-148-3-643	2002
Metabolism	Simultaneous analysis of spatio-temporal gene expression for cephamycin biosynthesis in Streptomyces clavuligerus.	Kyung YS, Sherman DH, Hu WS.	Biotechnol Prog	10.1021/bp0101076	2001
Metabolism	Genome mining in Streptomyces clavuligerus: expression and biochemical characterization of two new cryptic sesquiterpene synthases.	Hu Y, Chou WK, Hopson R, Cane DE.	Chem Biol	10.1016/j.chembiol.2010.11.008	2011
Genetics	Genome rearrangements and megaplasmid loss in the filamentous bacterium Kitasatospora viridifaciens are associated with protoplast formation and regeneration.	Ramijan K, Zhang Z, van Wezel GP, Claessen D.	Antonie Van Leeuwenhoek	10.1007/s10482-020-01393-7	2020
Pathogenicity	Repurposing Immunomodulatory Drugs to Combat Tuberculosis.	Fatima S, Bhaskar A, Dwivedi VP.	Front Immunol	10.3389/fimmu.2021.645485	2021
	A quantitative approach to characterizing cell lysis caused by mechanical agitation of Streptomyces clavuligerus.	Roubos JA, Krabben P, Luiten RG, Verbruggen HB, Heijnen JJ.	Biotechnol Prog	10.1021/bp0001617	2001
	ORF6 from the clavulanic acid gene cluster of Streptomyces clavuligerus has ornithine acetyltransferase activity.	Kershaw NJ, McNaughton HJ, Hewitson KS, Hernandez H, Griffin J, Hughes C, Greaves P, Barton B, Robinson CV, Schofield CJ.	Eur J Biochem	10.1046/j.1432-1033.2002.02853.x	2002
Metabolism	Evolution of beta-lactam biosynthesis genes and recruitment of trans-acting factors.	Brakhage AA, Al-Abdallah Q, Tuncher A, Sprote P.	Phytochemistry	10.1016/j.phytochem.2005.02.030	2005
	Naringenin and Hesperidin as Promising Alternatives for Prevention and Co-Adjuvant Therapy for Breast Cancer.	Madureira MB, Concato VM, Cruz EMS, Bitencourt de Morais JM, Inoue FSR, Concimo Santos N, Goncalves MD, Cremer de Souza M, Basso Scandolara T, Fontana Mezoni M, Galvani M, Rodrigues Ferreira Seiva F, Panis C, Miranda-Sapla MM, Pavanelli WR.	Antioxidants (Basel)	10.3390/antiox12030586	2023
Metabolism	ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid.	Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ.	J Biol Chem	10.1074/jbc.m507711200	2006
Metabolism	Structural and functional comparison of Saccharomonospora azurea strains in terms of primycin producing ability.	Kovacs M, Seffer D, Penzes-Huvos A, Juhasz A, Kerepesi I, Csepregi K, Kovacs-Valasek A, Fekete C.	World J Microbiol Biotechnol	10.1007/s11274-020-02935-x	2020
	Identification and characterization of the afsR homologue regulatory gene from Streptomyces peucetius ATCC 27952.	Parajuli N, Viet HT, Ishida K, Tong HT, Lee HC, Liou K, Sohng JK.	Res Microbiol	10.1016/j.resmic.2005.03.005	2005
Metabolism	Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.	Thai W, Paradkar AS, Jensen SE.	Microbiology (Reading)	10.1099/00221287-147-2-325	2001
Metabolism	Synthesis of cefminox by cell-free extracts of Streptomyces clavuligerus.	Kim JK, Kang H, Chae JS, Park YH, Choi YJ.	FEMS Microbiol Lett	10.1111/j.1574-6968.2000.tb08914.x	2000
Enzymology	Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus.	Bachmann BO, Townsend CA.	Biochemistry	10.1021/bi000709i	2000
	Characterization and expression of the arginine biosynthesis gene cluster of Streptomyces clavuligerus.	Rodriguez-Garcia A, de la Fuente A, Perez-Redondo R, Martin JF, Liras P.	J Mol Microbiol Biotechnol		2000
Metabolism	Coordinate production of cephamycin c and clavulanic acid by Streptomyces clavuligerus.	Thakur R, Roy MK, Dutta NN, Bezbaruah RL.	Indian J Exp Biol		1999
Metabolism	Mutational evidence supporting the involvement of tripartite residues His183, Asp185, and His243 in Streptomyces clavuligerus deacetoxycephalosporin C synthase for catalysis.	Sim J, Sim TS.	Biosci Biotechnol Biochem	10.1271/bbb.64.828	2000
Metabolism	Molecular basis for enhanced biosynthesis of clavulanic acid by a redox-cycling agent, phenazine methosulfate, in Streptomyces clavuligerus.	Kwon HJ, Kim SU.	Appl Microbiol Biotechnol	10.1007/s002530051614	1999
Metabolism	Further studies on the bioconversion of penicillin G into deacetoxycephalosporin G by resting cells of Streptomyces clavuligerus NP-1.	Baez-Vasquez MA, Adrio JL, Piret JM, Demain AL.	Appl Biochem Biotechnol	10.1385/abab:81:3:145	1999
	Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs.	Bhattacharya S, Junghare V, Pandey NK, Baidya S, Agarwal H, Das N, Banerjee A, Ghosh D, Roy P, Patra HK, Hazra S.	Front Microbiol	10.3389/fmicb.2021.710291	2021
Metabolism	Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity.	Chin HS, Sim J, Seah KI, Sim TS.	FEMS Microbiol Lett	10.1111/j.1574-6968.2003.tb11525.x	2003
Metabolism	A new class of glutamate dehydrogenases (GDH). Biochemical and genetic characterization of the first member, the AMP-requiring NAD-specific GDH of Streptomyces clavuligerus.	Minambres B, Olivera ER, Jensen RA, Luengo JM.	J Biol Chem	10.1074/jbc.m005136200	2000
	Pharmacokinetics of Clavulanic Acid in the Pediatric Population: A Systematic Literature Review.	Keij FM, Tramper-Stranders GA, Koch BCP, Reiss IKM, Muller AE, Kornelisse RF, Allegaert K.	Clin Pharmacokinet	10.1007/s40262-022-01116-3	2022
Metabolism	Glutamine-230 influences enzyme solubility but not catalysis in Streptomyces clavuligerus isopenicillin N synthase.	Loke P, Sim TS.	FEMS Microbiol Lett	10.1111/j.1574-6968.1999.tb13536.x	1999
Enzymology	Time-lapsed confocal microscopy reveals temporal and spatial expression of the lysine epsilon-aminotransferase gene in Streptomyces clavuligerus.	Han L, Khetan A, Hu WS, Sherman DH.	Mol Microbiol	10.1046/j.1365-2958.1999.01638.x	1999
Metabolism	Precursor and cofactor as a check valve for cephamycin biosynthesis in Streptomyces clavuligerus.	Khetan A, Malmberg LH, Kyung YS, Sherman DH, Hu WS.	Biotechnol Prog	10.1021/bp990090f	1999
Metabolism	Heterogeneous distribution of lysine 6-aminotransferase during cephamycin C biosynthesis in Streptomyces clavuligerus demonstrated using green fluorescent protein as a reporter.	Khetan A, Hu WS, Sherman DH.	Microbiology (Reading)	10.1099/00221287-146-8-1869	2000
	Efficient production of oxidized terpenoids via engineering fusion proteins of terpene synthase and cytochrome P450.	Wang X, Pereira JH, Tsutakawa S, Fang X, Adams PD, Mukhopadhyay A, Lee TS.	Metab Eng	10.1016/j.ymben.2021.01.004	2021
Metabolism	Activation of anthrachamycin biosynthesis in Streptomyces chattanoogensis L10 by site-directed mutagenesis of rpoB.	Li ZY, Bu QT, Wang J, Liu Y, Chen XA, Mao XM, Li YQ.	J Zhejiang Univ Sci B	10.1631/jzus.b1900344	2019
Metabolism	Improvement in the bioconversion of penicillin G to deacetoxycephalosporin G by elimination of agitation and addition of decane.	Gao Q, Demain AL.	Appl Microbiol Biotechnol	10.1007/s002530100817	2001
Metabolism	Effect of support materials on cephamycin C production by immobilized Streptomyces clavuligerus.	Sridevi V, Sridhar P.	Indian J Exp Biol		1999
Metabolism	Conformational flexibility of the C terminus with implications for substrate binding and catalysis revealed in a new crystal form of deacetoxycephalosporin C synthase.	Oster LM, van Scheltinga AC, Valegard K, Hose AM, Dubus A, Hajdu J, Andersson I.	J Mol Biol	10.1016/j.jmb.2004.07.049	2004
Metabolism	Monoterpene production by the carotenogenic yeast Rhodosporidium toruloides.	Zhuang X, Kilian O, Monroe E, Ito M, Tran-Gymfi MB, Liu F, Davis RW, Mirsiaghi M, Sundstrom E, Pray T, Skerker JM, George A, Gladden JM.	Microb Cell Fact	10.1186/s12934-019-1099-8	2019
	Controlling the substrate selectivity of deacetoxycephalosporin/deacetylcephalosporin C synthase.	Lloyd MD, Lipscomb SJ, Hewitson KS, Hensgens CM, Baldwin JE, Schofield CJ.	J Biol Chem	10.1074/jbc.m313928200	2004
	Partial characterization of cold active amylases and proteases of Streptomyces sp. from Antarctica.	Cotarlet M, Negoita TG, Bahrim GE, Stougaard P.	Braz J Microbiol	10.1590/s1517-83822011000300005	2011
Metabolism	Manipulation of the physiology of clavulanic acid production in Streptomyces clavuligerus.	Ives PR, Bushell ME.	Microbiology (Reading)	10.1099/00221287-143-11-3573	1997
Metabolism	The role of arginine residues in substrate binding and catalysis by deacetoxycephalosporin C synthase.	Lipscomb SJ, Lee HJ, Mukherji M, Baldwin JE, Schofield CJ, Lloyd MD.	Eur J Biochem	10.1046/j.1432-1033.2002.02945.x	2002
Metabolism	Crystal structures of the elusive Rhizobium etli L-asparaginase reveal a peculiar active site.	Loch JI, Imiolczyk B, Sliwiak J, Wantuch A, Bejger M, Gilski M, Jaskolski M.	Nat Commun	10.1038/s41467-021-27105-x	2021
Metabolism	Enhanced biosynthesis of clavulanic acid in Streptomyces clavuligerus due to oxidative challenge by redox-cycling agents.	Kwon HJ, Kim SU.	Appl Microbiol Biotechnol	10.1007/s002530051140	1998
Metabolism	A pathway-specific transcriptional activator regulates late steps of clavulanic acid biosynthesis in Streptomyces clavuligerus.	Paradkar AS, Aidoo KA, Jensen SE.	Mol Microbiol	10.1046/j.1365-2958.1998.00731.x	1998
Enzymology	Cloning and characterization of pcd encoding delta'-piperideine-6-carboxylate dehydrogenase from flavobacterium lutescens IFO3084.	Fujii T, Narita T, Agematu H, Agata N, Isshiki K.	J Biochem	10.1093/oxfordjournals.jbchem.a022849	2000
	The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.	Perez-Redondo R, Rodriguez-Garcia A, Martin JF, Liras P.	Gene	10.1016/s0378-1119(98)00106-1	1998
Metabolism	Effects of preculture variability on clavulanic acid fermentation.	Neves AA, Vieira LM, Menezes JC.	Biotechnol Bioeng	10.1002/1097-0290(20010320)72:6<628::aid-bit1028>3.0.co;2-l	2001
Pathogenicity	Induction of L-lysine epsilon-aminotransferase by L-lysine in Streptomyces clavuligerus, producer of cephalosporins.	Rius N, Maeda K, Demain AL.	FEMS Microbiol Lett	10.1111/j.1574-6968.1996.tb08532.x	1996
Metabolism	Secondary metabolism in simulated microgravity: beta-lactam production by Streptomyces clavuligerus.	Fang A, Pierson DL, Mishra SK, Koenig DW, Demain AL.	J Ind Microbiol Biotechnol	10.1038/sj.jim.2900345	1997
Metabolism	Clavulanic acid, a beta-lactamase inhibitor: biosynthesis and molecular genetics.	Liras P, Rodriguez-Garcia A.	Appl Microbiol Biotechnol	10.1007/s002530000420	2000
Enzymology	Partial purification, characterization and nitrogen regulation of the lysine epsilon-aminotransferase of Streptomyces clavuligerus.	Romero J, Martin JF, Liras P, Demain AL, Rius N.	J Ind Microbiol Biotechnol	10.1038/sj.jim.2900370	1997
	5S clavam biosynthesis is controlled by an atypical two-component regulatory system in Streptomyces clavuligerus.	Kwong T, Zelyas NJ, Cai H, Tahlan K, Wong A, Jensen SE.	Antimicrob Agents Chemother	10.1128/aac.01090-12	2012
	Biochemical pathways supporting beta-lactam biosynthesis in the springtail Folsomia candida.	Suring W, Marien J, Broekman R, van Straalen NM, Roelofs D.	Biol Open	10.1242/bio.019620	2016
	Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway.	Rodriguez-Garcia A, Ludovice M, Martin JF, Liras P.	Mol Microbiol	10.1046/j.1365-2958.1997.4511815.x	1997
	Production of clavulanic acid and cephamycin C by Streptomyces clavuligerus in palm-oil medium.	Lee PC, Ho CC.	World J Microbiol Biotechnol	10.1007/bf00327805	1996
Metabolism	Fermentative production of enantiopure (S)-linalool using a metabolically engineered Pantoea ananatis.	Nitta N, Tajima Y, Yamamoto Y, Moriya M, Matsudaira A, Hoshino Y, Nishio Y, Usuda Y.	Microb Cell Fact	10.1186/s12934-021-01543-0	2021
	The Neighboring Subunit Is Engaged to Stabilize the Substrate in the Active Site of Plant Arginases.	Sekula B.	Front Plant Sci	10.3389/fpls.2020.00987	2020
Metabolism	Dependence of nitrogen- and phosphorus-regulation of beta-lactam antibiotic production by Streptomyces clavuligerus on aeration level.	Fang A, Demain AL.	J Ind Microbiol	10.1007/bf01569965	1995
Metabolism	Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine.	Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC.	Nat Struct Biol	10.1038/90394	2001
Enzymology	Kinetic studies of clavulanic acid recovery by ion exchange chromatography.	Barboza M, Almeida RM, Hokka CO.	Bioseparation	10.1023/a:1016365827265	2001
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Metabolism	Environmentally safe production of 7-aminodeacetoxycephalosporanic acid (7-ADCA) using recombinant strains of Acremonium chrysogenum.	Velasco J, Luis Adrio J, Angel Moreno M, Diez B, Soler G, Barredo JL.	Nat Biotechnol	10.1038/78467	2000
Enzymology	Streptomyces spp. contain class Ia and class II ribonucleotide reductases: expression analysis of the genes in vegetative growth.	Borovok I, Kreisberg-Zakarin R, Yanko M, Schreiber R, Myslovati M, Aslund F, Holmgren A, Cohen G, Aharonowitz Y.	Microbiology (Reading)	10.1099/00221287-148-2-391	2002
Metabolism	Unexpected enhancement of beta-lactam antibiotic formation in Streptomyces clavuligerus by very high concentrations of exogenous lysine.	Fang A, Keables P, Demain AL.	Appl Microbiol Biotechnol	10.1007/bf00178606	1996
Metabolism	Streptomyces clavuligerus HlmI is an intramolecular disulfide-forming dithiol oxidase in holomycin biosynthesis.	Li B, Walsh CT.	Biochemistry	10.1021/bi200321c	2011
Enzymology	Crystallization and preliminary crystallographic studies of Helicobacter pylori arginase.	Zhang J, Zhang X, Mao X, Zou Q, Li D.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309111014242	2011
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Metabolism	A complete library of amino acid alterations at N304 in Streptomyces clavuligerus deacetoxycephalosporin C synthase elucidates the basis for enhanced penicillin analogue conversion.	Chin HS, Goo KS, Sim TS.	Appl Environ Microbiol	10.1128/aem.70.1.607-609.2004	2004
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Metabolism	Deep Sequencing of a Systematic Peptide Library Reveals Conformationally-Constrained Protein Interface Peptides that Disrupt a Protein-Protein Interaction.	Boragine DM, Huang W, Su LH, Palzkill T.	Chembiochem	10.1002/cbic.202100504	2022
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Metabolism	Production of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine by entrapped ACV-synthetase from Streptomyces clavuligerus.	Kadima TA, Jensen SE, Pickard MA.	J Ind Microbiol	10.1007/bf01570064	1995
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Metabolism	The role of glutamine oxoglutarate aminotransferase and glutamate dehydrogenase in nitrogen metabolism in Mycobacterium bovis BCG.	Viljoen AJ, Kirsten CJ, Baker B, van Helden PD, Wiid IJ.	PLoS One	10.1371/journal.pone.0084452	2013
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Metabolism	Enhanced Triacylglycerol Metabolism Contributes to Efficient Oil Utilization and High-Level Production of Salinomycin in Streptomyces albus ZD11.	Li H, Wei J, Dong J, Li Y, Li Y, Chen Y, Guan W.	Appl Environ Microbiol	10.1128/aem.00763-20	2020
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Enzymology	Possible involvement of the lysine epsilon-aminotransferase gene (lat) in the expression of the genes encoding ACV synthetase (pcbAB) and isopenicillin N synthase (pcbC) in Streptomyces clavuligerus.	Yu H, Serpe E, Romero J, Coque JJ, Maeda K, Oelgeschlager M, Hintermann G, Liras P, Martin JF, Demain AL.	Microbiology (Reading)	10.1099/13500872-140-12-3367	1994
Enzymology	A unique cysteine-rich zinc finger domain present in a majority of class II ribonucleotide reductases mediates catalytic turnover.	Loderer C, Jonna VR, Crona M, Rozman Grinberg I, Sahlin M, Hofer A, Lundin D, Sjoberg BM.	J Biol Chem	10.1074/jbc.m117.806331	2017
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Metabolism	A role for alanine in the ammonium regulation of cephalosporin biosynthesis in Streptomyces clavuligerus.	Kasarenini S, Demain AL.	J Ind Microbiol	10.1007/bf01569751	1994
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Metabolism	Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318.	Zhu XM, Zhang XX, Cheng RT, Yu HL, Yuan RS, Bu XL, Xu J, Ao P, Chen YC, Xu MJ.	R Soc Open Sci	10.1098/rsos.190418	2019
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Metabolism	Insight into the Molecular Mechanism of the Transcriptional Regulation of amtB Operon in Streptomyces coelicolor.	Li Z, Liu X, Wang J, Wang Y, Zheng G, Lu Y, Zhao G, Wang J.	Front Microbiol	10.3389/fmicb.2018.00264	2018
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Enzymology	Streptomyces flavogriseus HS1: isolation and characterization of extracellular proteases and their compatibility with laundry detergents.	Ghorbel S, Ghorbel S, Kammoun M, Soltana H, Nasri M, Hmidet N.	Biomed Res Int	10.1155/2014/345980	2014
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	Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases.	Glockzin K, Kostomiris D, Minnow YVT, Suthagar K, Clinch K, Gai S, Buckler JN, Schramm VL, Tyler PC, Meek TD, Katzfuss A.	Biochemistry	10.1021/acs.biochem.2c00312	2022
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Enzymology	Enzymatic characterisation of the multifunctional enzyme delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.	Schwecke T, Aharonowitz Y, Palissa H, von Dohren H, Kleinkauf H, van Liempt H.	Eur J Biochem	10.1111/j.1432-1033.1992.tb16830.x	1992
Metabolism	Stringent response and initiation of secondary metabolism in Streptomyces clavuligerus.	Bascaran V, Sanchez L, Hardisson C, Brana AF.	J Gen Microbiol	10.1099/00221287-137-7-1625	1991
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Metabolism	Proline uptake in Streptomyces clavuligerus.	Bascaran V, Hardisson C, Brana AF.	FEMS Microbiol Lett	10.1016/0378-1097(90)90407-h	1990
Metabolism	Studies on the active site of deacetoxycephalosporin C synthase.	Lloyd MD, Lee HJ, Harlos K, Zhang ZH, Baldwin JE, Schofield CJ, Charnock JM, Garner CD, Hara T, Terwisscha van Scheltinga AC, Valegard K, Viklund JA, Hajdu J, Andersson I, Danielsson A, Bhikhabhai R.	J Mol Biol	10.1006/jmbi.1999.2594	1999
Pathogenicity	Effect of dissolved oxygen control on growth and antibiotic production in Streptomyces clavuligerus fermentations.	Yegneswaran PK, Gray MR, Thompson BG.	Biotechnol Prog	10.1021/bp00009a008	1991
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Enzymology	Identification of Mycobacterium tuberculosis signal sequences that direct the export of a leaderless beta-lactamase gene product in Escherichia coli.	Chubb AJ, Woodman ZL, da Silva Tatley FMPR, Hoffmann HJ, Scholle RR, Ehlers MRW.	Microbiology (Reading)	10.1099/00221287-144-6-1619	1998
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Metabolism	Interdependence of gene expression for early steps of cephalosporin synthesis in Streptomyces clavuligerus.	Demain AL, Piret JM, Yu H, Coque JJ, Liras P, Martin JF.	Ann N Y Acad Sci	10.1111/j.1749-6632.1994.tb47383.x	1994
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Metabolism	Tripartite Regulation of the glpFKD Operon Involved in Glycerol Catabolism by GylR, Crp, and SigF in Mycobacterium smegmatis.	Bong HJ, Ko EM, Song SY, Ko IJ, Oh JI.	J Bacteriol	10.1128/jb.00511-19	2019
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Enzymology	Functional characterization of a new terpene synthase from Plectranthus amboinicus.	Ashaari NS, Ab Rahim MH, Sabri S, Lai KS, Song AA, Abdul Rahim R, Wan Abdullah WMAN, Ong Abdullah J.	PLoS One	10.1371/journal.pone.0235416	2020
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Enzymology	Laboratory evolution of Pyrococcus furiosus alcohol dehydrogenase to improve the production of (2S,5S)-hexanediol at moderate temperatures.	Machielsen R, Leferink NG, Hendriks A, Brouns SJ, Hennemann HG, Daussmann T, van der Oost J.	Extremophiles	10.1007/s00792-008-0164-8	2008
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Enzymology	Isolation and partial characterisation of ACV synthetase from Cephalosporium acremonium and Streptomyces clavuligerus. Evidence for the presence of phosphopantothenate in ACV synthetase.	Baldwin JE, Bird JW, Field RA, O'Callaghan NM, Schofield CJ, Willis AC.	J Antibiot (Tokyo)	10.7164/antibiotics.44.241	1991
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Enzymology	Production of Streptomyces clavuligerus isopenicillin N synthase in Escherichia coli using two-cistron expression systems.	Doran JL, Leskiw BK, Petrich AK, Westlake DW, Jensen SE.	J Ind Microbiol	10.1007/bf01569677	1990
Metabolism	Isolation and characterization of nitrogen-deregulated mutants of Streptomyces clavuligerus.	Bascaran V, Hardisson C, Brana AF.	J Gen Microbiol	10.1099/00221287-135-9-2475	1989
Metabolism	The fish pathogen Yersinia ruckeri produces holomycin and uses an RNA methyltransferase for self-resistance.	Qin Z, Baker AT, Raab A, Huang S, Wang T, Yu Y, Jaspars M, Secombes CJ, Deng H.	J Biol Chem	10.1074/jbc.m112.448415	2013
Enzymology	Regulation of nitrogen catabolic enzymes in Streptomyces clavuligerus.	Bascaran V, Hardisson C, Brana AF.	J Gen Microbiol	10.1099/00221287-135-9-2465	1989
Enzymology	Preliminary X-ray crystallographic analysis of ornithine acetyltransferase (Rv1653) from Mycobacterium tuberculosis.	Sankaranarayanan R, Garen CR, Cherney MM, Yuan M, Lee C, James MN.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309109000360	2009
Enzymology	Deacetoxycephalosporin C hydroxylase of Streptomyces clavuligerus. Purification, characterization, bifunctionality, and evolutionary implication.	Baker BJ, Dotzlaf JE, Yeh WK.	J Biol Chem	10.1016/s0021-9258(19)67759-8	1991
Metabolism	Phosphate regulation of ACV synthetase and cephalosporin biosynthesis in Streptomyces clavuligerus.	Jhang J, Wolfe S, Demain AL.	FEMS Microbiol Lett	10.1111/j.1574-6968.1989.tb03289.x	1989
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Enzymology	Directed evolution of Streptomyces clavuligerus deacetoxycephalosporin C synthase for enhancement of penicillin G expansion.	Wei CL, Yang YB, Deng CH, Liu WC, Hsu JS, Lin YC, Liaw SH, Tsai YC.	Appl Environ Microbiol	10.1128/aem.71.12.8873-8880.2005	2005
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Enzymology	Measurement of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase activity in Streptomyces clavuligerus by high-performance liquid chromatography after precolumn derivatization with o-phthaldialdehyde.	White RL, DeMarco AC, Shapiro S, Vining LC, Wolfe S.	Anal Biochem	10.1016/0003-2697(89)90660-x	1989
Metabolism	Regioselectivity of hyoscyamine 6beta-hydroxylase-catalysed hydroxylation as revealed by high-resolution structural information and QM/MM calculations.	Kluza A, Wojdyla Z, Mrugala B, Kurpiewska K, Porebski PJ, Niedzialkowska E, Minor W, Weiss MS, Borowski T.	Dalton Trans	10.1039/d0dt00302f	2020
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Metabolism	ATP regulation in bioproduction.	Hara KY, Kondo A.	Microb Cell Fact	10.1186/s12934-015-0390-6	2015
	Discovery of an insertion sequence, IS116, from Streptomyces clavuligerus and its relatedness to other transposable elements from actinomycetes.	Leskiw BK, Mevarech M, Barritt LS, Jensen SE, Henderson DJ, Hopwood DA, Bruton CJ, Chater KF.	J Gen Microbiol	10.1099/00221287-136-7-1251	1990
Enzymology	Purification and properties of isopenicillin N epimerase from Streptomyces clavuligerus.	Usui S, Yu CA.	Biochim Biophys Acta	10.1016/0167-4838(89)90033-2	1989
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Metabolism	Isopenicillin N synthase and desacetoxycephalosporin C synthase activities during defined medium fermentations of Streptomyces clavuligerus: effect of oxygen and iron supplements.	Rollins MJ, Jensen SE, Westlake DW.	Can J Microbiol	10.1139/m89-186	1989
Transcriptome	Characterization of IS1110, a highly mobile genetic element from Mycobacterium avium.	Hernandez Perez M, Fomukong NG, Hellyer T, Brown IN, Dale JW.	Mol Microbiol	10.1111/j.1365-2958.1994.tb01059.x	1994
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Metabolism	Cyclization of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine to penicillins by cell-free extracts of Streptomyces clavuligerus.	Jensen SE, Westlake DW, Wolfe S.	J Antibiot (Tokyo)	10.7164/antibiotics.35.483	1982
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Metabolism	Significance of Heavy-Ion Beam Irradiation-Induced Avermectin B1a Production by Engineered Streptomyces avermitilis.	Wang SY, Bo YH, Zhou X, Chen JH, Li WJ, Liang JP, Xiao GQ, Wang YC, Liu J, Hu W, Jiang BL.	Biomed Res Int	10.1155/2017/5373262	2017
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	Identification of a cluster-situated activator of oxytetracycline biosynthesis and manipulation of its expression for improved oxytetracycline production in Streptomyces rimosus.	Yin S, Wang W, Wang X, Zhu Y, Jia X, Li S, Yuan F, Zhang Y, Yang K.	Microb Cell Fact	10.1186/s12934-015-0231-7	2015
Metabolism	The structure at 2.4 A resolution of the protein from gene locus At3g21360, a putative Fe(II)/2-oxoglutarate-dependent enzyme from Arabidopsis thaliana.	Bitto E, Bingman CA, Allard ST, Wesenberg GE, Aceti DJ, Wrobel RL, Frederick RO, Sreenath H, Vojtik FC, Jeon WB, Newman CS, Primm J, Sussman MR, Fox BG, Markley JL, Phillips GN.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309105011565	2005
Enzymology	An N-acyl homolog of mycothiol is produced in marine actinomycetes.	Newton GL, Jensen PR, Macmillan JB, Fenical W, Fahey RC.	Arch Microbiol	10.1007/s00203-008-0405-3	2008
Metabolism	Genes specific for the biosynthesis of clavam metabolites antipodal to clavulanic acid are clustered with the gene for clavaminate synthase 1 in Streptomyces clavuligerus.	Mosher RH, Paradkar AS, Anders C, Barton B, Jensen SE.	Antimicrob Agents Chemother	10.1128/aac.43.5.1215	1999
Metabolism	beta-Lactam synthetase: a new biosynthetic enzyme.	Bachmann BO, Li R, Townsend CA.	Proc Natl Acad Sci U S A	10.1073/pnas.95.16.9082	1998
Metabolism	Studies on the biosynthesis of clavulanic acid. I. Incorporation of 13C-labelled precursors.	Elson SW, Oliver RS.	J Antibiot (Tokyo)	10.7164/antibiotics.31.586	1978
Metabolism	Role of beta-lactamase residues in a common interface for binding the structurally unrelated inhibitory proteins BLIP and BLIP-II.	Fryszczyn BG, Adamski CJ, Brown NG, Rice K, Huang W, Palzkill T.	Protein Sci	10.1002/pro.2505	2014
	Shared Genomic Regions Underlie Natural Variation in Diverse Toxin Responses.	Evans KS, Brady SC, Bloom JS, Tanny RE, Cook DE, Giuliani SE, Hippleheuser SW, Zamanian M, Andersen EC.	Genetics	10.1534/genetics.118.301311	2018
Metabolism	Identification and characterization of NocR as a positive transcriptional regulator of the beta-lactam nocardicin A in Nocardia uniformis.	Davidsen JM, Townsend CA.	J Bacteriol	10.1128/jb.01833-07	2009
Metabolism	Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.	Lambrecht JA, Flynn JM, Downs DM.	J Biol Chem	10.1074/jbc.m111.304477	2012
Enzymology	Biochemical studies on the activity of delta-(L-alpha-aminoadipyl)-L-cysteinyl-D-valine synthetase from Streptomyces clavuligerus.	Zhang J, Wolfe S, Demain AL.	Biochem J	10.1042/bj2830691	1992
Metabolism	Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus.	Dolan SK, Bock T, Hering V, Owens RA, Jones GW, Blankenfeldt W, Doyle S.	Open Biol	10.1098/rsob.160292	2017
	Molecular mechanisms of persistence of mutualistic bacteria Photorhabdus in the entomopathogenic nematode host.	An R, Grewal PS.	PLoS One	10.1371/journal.pone.0013154	2010
Enzymology	Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal.	Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT.	PLoS One	10.1371/journal.pone.0167763	2016
Metabolism	The conversion of cephalosporins to 7 alpha-methoxycephalosporins by cell-free extracts of Streptomyces clavuligerus.	O'Sullivan J, Abraham EP.	Biochem J	10.1042/bj1860613	1980
Metabolism	Characterization of LipL as a non-heme, Fe(II)-dependent alpha-ketoglutarate:UMP dioxygenase that generates uridine-5'-aldehyde during A-90289 biosynthesis.	Yang Z, Chi X, Funabashi M, Baba S, Nonaka K, Pahari P, Unrine J, Jacobsen JM, Elliott GI, Rohr J, Van Lanen SG.	J Biol Chem	10.1074/jbc.m110.203562	2011
Metabolism	Mutation of the Erwinia amylovora argD gene causes arginine auxotrophy, nonpathogenicity in apples, and reduced virulence in pears.	Ramos LS, Lehman BL, Peter KA, McNellis TW.	Appl Environ Microbiol	10.1128/aem.02404-14	2014
Metabolism	Peroxiredoxin 1 (Prx1) is a dual-function enzyme by possessing Cys-independent catalase-like activity.	Sun CC, Dong WR, Shao T, Li JY, Zhao J, Nie L, Xiang LX, Zhu G, Shao JZ.	Biochem J	10.1042/bcj20160851	2017
	Comprehensive understanding of acetohydroxyacid synthase inhibition by different herbicide families.	Garcia MD, Nouwens A, Lonhienne TG, Guddat LW.	Proc Natl Acad Sci U S A	10.1073/pnas.1616142114	2017
	FuncTree: Functional Analysis and Visualization for Large-Scale Omics Data.	Uchiyama T, Irie M, Mori H, Kurokawa K, Yamada T.	PLoS One	10.1371/journal.pone.0126967	2015
Genetics	Comparative genomics reveals evidence of marine adaptation in Salinispora species.	Penn K, Jensen PR.	BMC Genomics	10.1186/1471-2164-13-86	2012
Metabolism	CcpA regulates arginine biosynthesis in Staphylococcus aureus through repression of proline catabolism.	Nuxoll AS, Halouska SM, Sadykov MR, Hanke ML, Bayles KW, Kielian T, Powers R, Fey PD.	PLoS Pathog	10.1371/journal.ppat.1003033	2012
Phylogeny	Comparative genomic and phylogenetic approaches to characterize the role of genetic recombination in mycobacterial evolution.	Smith SE, Showers-Corneli P, Dardenne CN, Harpending HH, Martin DP, Beiko RG.	PLoS One	10.1371/journal.pone.0050070	2012
Metabolism	Quantitative determination of free-DNA uptake in river bacteria at the single-cell level by in situ rolling-circle amplification.	Maruyama F, Tani K, Kenzaka T, Yamaguchi N, Nasu M.	Appl Environ Microbiol	10.1128/aem.03035-05	2006
	Novel chemical space exploration via natural products.	Rosen J, Gottfries J, Muresan S, Backlund A, Oprea TI.	J Med Chem	10.1021/jm801514w	2009
Metabolism	NdgR, a common transcriptional activator for methionine and leucine biosynthesis in Streptomyces coelicolor.	Kim SH, Lee BR, Kim JN, Kim BG.	J Bacteriol	10.1128/jb.00695-12	2012
	Synthetic Biology in Natural Product Biosynthesis.	Seshadri K, Abad AND, Nagasawa KK, Yost KM, Johnson CW, Dror MJ, Tang Y.	Chem Rev	10.1021/acs.chemrev.4c00567	2025
Enzymology	The structures of pyruvate oxidase from Aerococcus viridans with cofactors and with a reaction intermediate reveal the flexibility of the active-site tunnel for catalysis.	Juan EC, Hoque MM, Hossain MT, Yamamoto T, Imamura S, Suzuki K, Sekiguchi T, Takenaka A.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309107041012	2007
Metabolism	Deletion of the signalling molecule synthase ScbA has pleiotropic effects on secondary metabolite biosynthesis, morphological differentiation and primary metabolism in Streptomyces coelicolor A3(2).	D'Alia D, Eggle D, Nieselt K, Hu WS, Breitling R, Takano E.	Microb Biotechnol	10.1111/j.1751-7915.2010.00232.x	2011
Enzymology	Structural basis for leucine-induced allosteric activation of glutamate dehydrogenase.	Tomita T, Kuzuyama T, Nishiyama M.	J Biol Chem	10.1074/jbc.m111.260265	2011
Metabolism	Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.	Makitrynskyy R, Ostash B, Tsypik O, Rebets Y, Doud E, Meredith T, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V.	Open Biol	10.1098/rsob.130121	2013
Metabolism	Methods to optimize myxobacterial fermentations using off-gas analysis.	Huttel S, Muller R.	Microb Cell Fact	10.1186/1475-2859-11-59	2012
	A Review of the Microbial Production of Bioactive Natural Products and Biologics.	Pham JV, Yilma MA, Feliz A, Majid MT, Maffetone N, Walker JR, Kim E, Cho HJ, Reynolds JM, Song MC, Park SR, Yoon YJ.	Front Microbiol	10.3389/fmicb.2019.01404	2019
Metabolism	The Role of Bacillithiol in Gram-Positive Firmicutes.	Chandrangsu P, Loi VV, Antelmann H, Helmann JD.	Antioxid Redox Signal	10.1089/ars.2017.7057	2018
Metabolism	Identification and characterization of CdgB, a diguanylate cyclase involved in developmental processes in Streptomyces coelicolor.	Tran NT, Den Hengst CD, Gomez-Escribano JP, Buttner MJ.	J Bacteriol	10.1128/jb.01460-10	2011
Genetics	Reconstruction of a Streptomyces linear replicon from separately cloned DNA fragments: existence of a cryptic origin of circular replication within the linear plasmid.	Shiffman D, Cohen SN.	Proc Natl Acad Sci U S A	10.1073/pnas.89.13.6129	1992
Enzymology	Three-dimensional structure of nylon hydrolase and mechanism of nylon-6 hydrolysis.	Negoro S, Shibata N, Tanaka Y, Yasuhira K, Shibata H, Hashimoto H, Lee YH, Oshima S, Santa R, Oshima S, Mochiji K, Goto Y, Ikegami T, Nagai K, Kato D, Takeo M, Higuchi Y.	J Biol Chem	10.1074/jbc.m111.321992	2012
Metabolism	The capsular polysaccharide of Staphylococcus aureus is attached to peptidoglycan by the LytR-CpsA-Psr (LCP) family of enzymes.	Chan YG, Kim HK, Schneewind O, Missiakas D.	J Biol Chem	10.1074/jbc.m114.567669	2014
Metabolism	A new TetR family transcriptional regulator required for morphogenesis in Streptomyces coelicolor.	Hillerich B, Westpheling J.	J Bacteriol	10.1128/jb.01316-07	2008
	Genome-wide inference of regulatory networks in Streptomyces coelicolor.	Castro-Melchor M, Charaniya S, Karypis G, Takano E, Hu WS.	BMC Genomics	10.1186/1471-2164-11-578	2010
Enzymology	Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity.	Sauvage E, Fonze E, Quinting B, Galleni M, Frere JM, Charlier P.	Antimicrob Agents Chemother	10.1128/aac.01226-05	2006
Metabolism	Differential proteomic profiling reveals regulatory proteins and novel links between primary metabolism and spinosad production in Saccharopolyspora spinosa.	Yang Q, Ding X, Liu X, Liu S, Sun Y, Yu Z, Hu S, Rang J, He H, He L, Xia L.	Microb Cell Fact	10.1186/1475-2859-13-27	2014
	Convergent transcription in the butyrolactone regulon in Streptomyces coelicolor confers a bistable genetic switch for antibiotic biosynthesis.	Chatterjee A, Drews L, Mehra S, Takano E, Kaznessis YN, Hu WS.	PLoS One	10.1371/journal.pone.0021974	2011
Pathogenicity	Repression of the antifungal activity of Pseudomonas sp. strain DF41 by the stringent response.	Manuel J, Berry C, Selin C, Fernando WG, de Kievit TR.	Appl Environ Microbiol	10.1128/aem.02875-10	2011
	A bistable gene switch for antibiotic biosynthesis: the butyrolactone regulon in Streptomyces coelicolor.	Mehra S, Charaniya S, Takano E, Hu WS.	PLoS One	10.1371/journal.pone.0002724	2008
Metabolism	Resuscitation-promoting factors are cell wall-lytic enzymes with important roles in the germination and growth of Streptomyces coelicolor.	Sexton DL, St-Onge RJ, Haiser HJ, Yousef MR, Brady L, Gao C, Leonard J, Elliot MA.	J Bacteriol	10.1128/jb.02464-14	2015
Metabolism	Staphylococcus aureus mutants lacking the LytR-CpsA-Psr family of enzymes release cell wall teichoic acids into the extracellular medium.	Chan YG, Frankel MB, Dengler V, Schneewind O, Missiakas D.	J Bacteriol	10.1128/jb.00544-13	2013
Metabolism	Characterization of the 'pristinamycin supercluster' of Streptomyces pristinaespiralis.	Mast Y, Weber T, Golz M, Ort-Winklbauer R, Gondran A, Wohlleben W, Schinko E.	Microb Biotechnol	10.1111/j.1751-7915.2010.00213.x	2011
Metabolism	Interplay between Gliotoxin Resistance, Secretion, and the Methyl/Methionine Cycle in Aspergillus fumigatus.	Owens RA, O'Keeffe G, Smith EB, Dolan SK, Hammel S, Sheridan KJ, Fitzpatrick DA, Keane TM, Jones GW, Doyle S.	Eukaryot Cell	10.1128/ec.00055-15	2015
Pathogenicity	arsRBOCT arsenic resistance system encoded by linear plasmid pHZ227 in Streptomyces sp. strain FR-008.	Wang L, Chen S, Xiao X, Huang X, You D, Zhou X, Deng Z.	Appl Environ Microbiol	10.1128/aem.72.5.3738-3742.2006	2006
Metabolism	Glutamate dehydrogenase and glutamine synthetase are regulated in response to nitrogen availability in Myocbacterium smegmatis.	Harper CJ, Hayward D, Kidd M, Wiid I, van Helden P.	BMC Microbiol	10.1186/1471-2180-10-138	2010
Metabolism	Incorporation of labeled precursors into A16886B, a novel -lactam antibiotic produced by Streptomyces clavuligerus.	Whitney JG, Brannon DR, Mabe JA, Wicker KJ.	Antimicrob Agents Chemother	10.1128/aac.1.3.247	1972
	Identification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.	Brown NG, Palzkill T.	Protein Eng Des Sel	10.1093/protein/gzq017	2010
Metabolism	Use of periplasmic target protein capture for phage display engineering of tight-binding protein-protein interactions.	Fryszczyn BG, Brown NG, Huang W, Balderas MA, Palzkill T.	Protein Eng Des Sel	10.1093/protein/gzr043	2011
Enzymology	Purification of isopenicillin N synthetase.	Pang CP, Chakravarti B, Adlington RM, Ting HH, White RL, Jayatilake GS, Baldwin JE, Abraham EP.	Biochem J	10.1042/bj2220789	1984
	A synthetic luxCDABE gene cluster optimized for expression in high-GC bacteria.	Craney A, Hohenauer T, Xu Y, Navani NK, Li Y, Nodwell J.	Nucleic Acids Res	10.1093/nar/gkm086	2007
	A Combinatorial Algorithm for Microbial Consortia Synthetic Design.	Julien-Laferriere A, Bulteau L, Parrot D, Marchetti-Spaccamela A, Stougie L, Vinga S, Mary A, Sagot MF.	Sci Rep	10.1038/srep29182	2016
Metabolism	SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.	Kirm B, Magdevska V, Tome M, Horvat M, Karnicar K, Petek M, Vidmar R, Baebler S, Jamnik P, Fujs S, Horvat J, Fonovic M, Turk B, Gruden K, Petkovic H, Kosec G.	Microb Cell Fact	10.1186/1475-2859-12-126	2013
Metabolism	Regulation of cephamycin C synthesis, aspartokinase, dihydrodipicolinic acid synthetase, and homoserine dehydrogenase by aspartic acid family amino acids in Streptomyces clavuligerus.	Mendelovitz S, Aharonowitz Y.	Antimicrob Agents Chemother	10.1128/aac.21.1.74	1982
	The closest relatives of icosahedral viruses of thermophilic bacteria are among viruses and plasmids of the halophilic archaea.	Jalasvuori M, Jaatinen ST, Laurinavicius S, Ahola-Iivarinen E, Kalkkinen N, Bamford DH, Bamford JK.	J Virol	10.1128/jvi.00869-09	2009
Metabolism	Cross-talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces.	Martin JF, Sola-Landa A, Santos-Beneit F, Fernandez-Martinez LT, Prieto C, Rodriguez-Garcia A.	Microb Biotechnol	10.1111/j.1751-7915.2010.00235.x	2011
Metabolism	BldG and SCO3548 interact antagonistically to control key developmental processes in Streptomyces coelicolor.	Parashar A, Colvin KR, Bignell DR, Leskiw BK.	J Bacteriol	10.1128/jb.01695-08	2009
Enzymology	Insight into the Sialome of the Bed Bug, Cimex lectularius.	Francischetti IM, Calvo E, Andersen JF, Pham VM, Favreau AJ, Barbian KD, Romero A, Valenzuela JG, Ribeiro JM.	J Proteome Res	10.1021/pr1000169	2010
Enzymology	An adenosine triphosphate-dependent carbamoylphosphate--3-hydroxymethylcephem O-carbamoyltransferase from Streptomyces clavuligerus.	Brewer SJ, Taylor PM, Turner MK.	Biochem J	10.1042/bj1850555	1980
Pathogenicity	Inducing effect of diamines on transcription of the cephamycin C genes from the lat and pcbAB promoters in Nocardia lactamdurans.	Leitao AL, Enguita FJ, De La Fuente JL, Liras P, Martin JF.	J Bacteriol	10.1128/jb.181.8.2379-2384.1999	1999
	Resistance to beta-lactamase inhibitor protein does not parallel resistance to clavulanic acid in TEM beta-lactamase mutants.	Schroeder WA, Locke TR, Jensen SE.	Antimicrob Agents Chemother	10.1128/aac.46.11.3568-3573.2002	2002
Metabolism	Biosynthesis of a 7-alpha-methoxycephalosporin. Incorporation of molecular oxygen.	O'Sullivan J, Aplin RT, Stevens CM, Abraham EP.	Biochem J	10.1042/bj1790047	1979
	Kinetic, crystallographic, and mechanistic characterization of TomN: elucidation of a function for a 4-oxalocrotonate tautomerase homologue in the tomaymycin biosynthetic pathway.	Burks EA, Yan W, Johnson WH, Li W, Schroeder GK, Min C, Gerratana B, Zhang Y, Whitman CP.	Biochemistry	10.1021/bi200947w	2011
	Analysis of the binding forces driving the tight interactions between beta-lactamase inhibitory protein-II (BLIP-II) and class A beta-lactamases.	Brown NG, Chow DC, Sankaran B, Zwart P, Prasad BV, Palzkill T.	J Biol Chem	10.1074/jbc.m111.265058	2011
	Identification and utility of FdmR1 as a Streptomyces antibiotic regulatory protein activator for fredericamycin production in Streptomyces griseus ATCC 49344 and heterologous hosts.	Chen Y, Wendt-Pienkowski E, Shen B.	J Bacteriol	10.1128/jb.00592-08	2008
Enzymology	Confronting the catalytic dark matter encoded by sequenced genomes.	Ellens KW, Christian N, Singh C, Satagopam VP, May P, Linster CL.	Nucleic Acids Res	10.1093/nar/gkx937	2017
	X-ray crystal structure of ornithine acetyltransferase from the clavulanic acid biosynthesis gene cluster.	Elkins JM, Kershaw NJ, Schofield CJ.	Biochem J	10.1042/bj20040814	2005
Pathogenicity	Host-pathogen interactions between the human innate immune system and Candida albicans-understanding and modeling defense and evasion strategies.	Duhring S, Germerodt S, Skerka C, Zipfel PF, Dandekar T, Schuster S.	Front Microbiol	10.3389/fmicb.2015.00625	2015
Metabolism	The 1.5-A structure of XplA-heme, an unusual cytochrome P450 heme domain that catalyzes reductive biotransformation of royal demolition explosive.	Sabbadin F, Jackson R, Haider K, Tampi G, Turkenburg JP, Hart S, Bruce NC, Grogan G.	J Biol Chem	10.1074/jbc.m109.031559	2009
Enzymology	Oligomeric structure of proclavaminic acid amidino hydrolase: evolution of a hydrolytic enzyme in clavulanic acid biosynthesis.	Elkins JM, Clifton IJ, Hernandez H, Doan LX, Robinson CV, Schofield CJ, Hewitson KS.	Biochem J	10.1042/bj20020125	2002
Enzymology	The oxygenation of [3-methyl-3H]desacetoxycephalosporin C [7beta-(5-D-aminadipamido)-3-methylceph-3-em-4-carboxylic acid] to [3-hydroxymethyl-3H]desacetylcephalosporin C by 2-oxoglutarate-linked dioxygenases from Acremonium chrysogenum and Streptomyces clavuligerus.	Turner MK, Farthing JE, Brewer SJ.	Biochem J	10.1042/bj1730839	1978
Metabolism	ArgR of Streptomyces coelicolor is a versatile regulator.	Perez-Redondo R, Rodriguez-Garcia A, Botas A, Santamarta I, Martin JF, Liras P.	PLoS One	10.1371/journal.pone.0032697	2012
Pathogenicity	Biosynthetic pathway for mannopeptimycins, lipoglycopeptide antibiotics active against drug-resistant gram-positive pathogens.	Magarvey NA, Haltli B, He M, Greenstein M, Hucul JA.	Antimicrob Agents Chemother	10.1128/aac.01545-05	2006
Metabolism	Phosphorylated AbsA2 negatively regulates antibiotic production in Streptomyces coelicolor through interactions with pathway-specific regulatory gene promoters.	McKenzie NL, Nodwell JR.	J Bacteriol	10.1128/jb.00305-07	2007
Metabolism	RNA-seq reveals the pan-transcriptomic impact of attenuating the gliotoxin self-protection mechanism in Aspergillus fumigatus.	O'Keeffe G, Hammel S, Owens RA, Keane TM, Fitzpatrick DA, Jones GW, Doyle S.	BMC Genomics	10.1186/1471-2164-15-894	2014
	Mycobacterium avium genes associated with the ability to form a biofilm.	Yamazaki Y, Danelishvili L, Wu M, Macnab M, Bermudez LE.	Appl Environ Microbiol	10.1128/aem.72.1.819-825.2006	2006
Metabolism	Synthesis and uptake of the compatible solutes ectoine and 5-hydroxyectoine by Streptomyces coelicolor A3(2) in response to salt and heat stresses.	Bursy J, Kuhlmann AU, Pittelkow M, Hartmann H, Jebbar M, Pierik AJ, Bremer E.	Appl Environ Microbiol	10.1128/aem.00768-08	2008
Genetics	Efficient identification of Y chromosome sequences in the human and Drosophila genomes.	Carvalho AB, Clark AG.	Genome Res	10.1101/gr.156034.113	2013
Pathogenicity	Crystal structure and activity studies of the Mycobacterium tuberculosis beta-lactamase reveal its critical role in resistance to beta-lactam antibiotics.	Wang F, Cassidy C, Sacchettini JC.	Antimicrob Agents Chemother	10.1128/aac.00320-06	2006
Enzymology	An orphan histidine kinase, OhkA, regulates both secondary metabolism and morphological differentiation in Streptomyces coelicolor.	Lu Y, He J, Zhu H, Yu Z, Wang R, Chen Y, Dang F, Zhang W, Yang S, Jiang W.	J Bacteriol	10.1128/jb.00017-11	2011
	Identification, cloning, sequencing, and overexpression of the gene encoding proclavaminate amidino hydrolase and characterization of protein function in clavulanic acid biosynthesis.	Wu TK, Busby RW, Houston TA, McIlwaine DB, Egan LA, Townsend CA.	J Bacteriol	10.1128/jb.177.13.3714-3720.1995	1995
	Morphological development of Aspergillus niger in submerged citric acid fermentation as a function of the spore inoculum level. Application of neural network and cluster analysis for characterization of mycelial morphology.	Papagianni M, Mattey M.	Microb Cell Fact	10.1186/1475-2859-5-3	2006
Enzymology	ACI-1 from Acidaminococcus fermentans: characterization of the first beta-lactamase in Anaerobic cocci.	Galan JC, Reig M, Navas A, Baquero F, Blazquez J.	Antimicrob Agents Chemother	10.1128/aac.44.11.3144-3149.2000	2000
	The mithramycin gene cluster of Streptomyces argillaceus contains a positive regulatory gene and two repeated DNA sequences that are located at both ends of the cluster.	Lombo F, Brana AF, Mendez C, Salas JA.	J Bacteriol	10.1128/jb.181.2.642-647.1999	1999
Metabolism	Characterization of a new LexA binding motif in the marine magnetotactic bacterium strain MC-1.	Fernandez de Henestrosa AR, Cune J, Mazon G, Dubbels BL, Bazylinski DA, Barbe J.	J Bacteriol	10.1128/jb.185.15.4471-4482.2003	2003
	Probing the specificity determinants of amino acid recognition by arginase.	Shishova EY, Di Costanzo L, Emig FA, Ash DE, Christianson DW.	Biochemistry	10.1021/bi801911v	2009
Pathogenicity	Genome-wide dynamics of a bacterial response to antibiotics that target the cell envelope.	Hesketh A, Hill C, Mokhtar J, Novotna G, Tran N, Bibb M, Hong HJ.	BMC Genomics	10.1186/1471-2164-12-226	2011
	A computational analysis of the three isoforms of glutamate dehydrogenase reveals structural features of the isoform EC 1.4.1.4 supporting a key role in ammonium assimilation by plants.	Jaspard E.	Biol Direct	10.1186/1745-6150-1-38	2006
Enzymology	Genetic and structural insights into the dissemination potential of the extremely broad-spectrum class A beta-lactamase KPC-2 identified in an Escherichia coli strain and an Enterobacter cloacae strain isolated from the same patient in France.	Petrella S, Ziental-Gelus N, Mayer C, Renard M, Jarlier V, Sougakoff W.	Antimicrob Agents Chemother	10.1128/aac.00163-08	2008
Metabolism	The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnema pretiosum.	Yu TW, Bai L, Clade D, Hoffmann D, Toelzer S, Trinh KQ, Xu J, Moss SJ, Leistner E, Floss HG.	Proc Natl Acad Sci U S A	10.1073/pnas.092697199	2002
Enzymology	Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials.	Choudhary A, Naughton LM, Montanchez I, Dobson ADW, Rai DK.	Mar Drugs	10.3390/md15090272	2017
Transcriptome	Analyzing DNA strand compositional asymmetry to identify candidate replication origins of Borrelia burgdorferi linear and circular plasmids.	Picardeau M, Lobry JR, Hinnebusch BJ.	Genome Res	10.1101/gr.124000	2000
	Evidence that an additional mutation is required to tolerate insertional inactivation of the Streptomyces lividans recA gene.	Vierling S, Weber T, Wohlleben W, Muth G.	J Bacteriol	10.1128/jb.183.14.4374-4381.2001	2001
	Adaptive laboratory evolution -- principles and applications for biotechnology.	Dragosits M, Mattanovich D.	Microb Cell Fact	10.1186/1475-2859-12-64	2013
Enzymology	Biochemical-genetic analysis and distribution of FAR-1, a class A beta-lactamase from Nocardia farcinica.	Laurent F, Poirel L, Naas T, Chaibi EB, Labia R, Boiron P, Nordmann P.	Antimicrob Agents Chemother	10.1128/aac.43.7.1644	1999
Metabolism	The genome of Pelobacter carbinolicus reveals surprising metabolic capabilities and physiological features.	Aklujkar M, Haveman SA, DiDonato R, Chertkov O, Han CS, Land ML, Brown P, Lovley DR.	BMC Genomics	10.1186/1471-2164-13-690	2012
	Identification of the novobiocin biosynthetic gene cluster of Streptomyces spheroides NCIB 11891.	Steffensky M, Muhlenweg A, Wang ZX, Li SM, Heide L.	Antimicrob Agents Chemother	10.1128/aac.44.5.1214-1222.2000	2000
	Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.	Kemung HM, Tan LT, Khan TM, Chan KG, Pusparajah P, Goh BH, Lee LH.	Front Microbiol	10.3389/fmicb.2018.02221	2018
Metabolism	A-factor and phosphate depletion signals are transmitted to the grixazone biosynthesis genes via the pathway-specific transcriptional activator GriR.	Higashi T, Iwasaki Y, Ohnishi Y, Horinouchi S.	J Bacteriol	10.1128/jb.00055-07	2007
	Partitioning of the linear chromosome during sporulation of Streptomyces coelicolor A3(2) involves an oriC-linked parAB locus.	Kim HJ, Calcutt MJ, Schmidt FJ, Chater KF.	J Bacteriol	10.1128/jb.182.5.1313-1320.2000	2000
	A novel immunity system for bacterial nucleic acid degrading toxins and its recruitment in various eukaryotic and DNA viral systems.	Zhang D, Iyer LM, Aravind L.	Nucleic Acids Res	10.1093/nar/gkr036	2011
	ArgR-independent induction and ArgR-dependent superinduction of the astCADBE operon in Escherichia coli.	Kiupakis AK, Reitzer L.	J Bacteriol	10.1128/jb.184.11.2940-2950.2002	2002
Metabolism	The twin-arginine translocation pathway of Mycobacterium smegmatis is functional and required for the export of mycobacterial beta-lactamases.	McDonough JA, Hacker KE, Flores AR, Pavelka MS, Braunstein M.	J Bacteriol	10.1128/jb.187.22.7667-7679.2005	2005
Metabolism	Complete nucleotide sequence of the 113-kilobase linear catabolic plasmid pAL1 of Arthrobacter nitroguajacolicus Rü61a and transcriptional analysis of genes involved in quinaldine degradation.	Parschat K, Overhage J, Strittmatter AW, Henne A, Gottschalk G, Fetzner S.	J Bacteriol	10.1128/jb.00089-07	2007
Metabolism	Essential thioredoxin-dependent peroxiredoxin system from Helicobacter pylori: genetic and kinetic characterization.	Baker LM, Raudonikiene A, Hoffman PS, Poole LB.	J Bacteriol	10.1128/jb.183.6.1961-1973.2001	2001
Metabolism	Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media.	Hottes AK, Meewan M, Yang D, Arana N, Romero P, McAdams HH, Stephens C.	J Bacteriol	10.1128/jb.186.5.1448-1461.2004	2004
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Metabolism	Cohesion group approach for evolutionary analysis of aspartokinase, an enzyme that feeds a branched network of many biochemical pathways.	Lo CC, Bonner CA, Xie G, D'Souza M, Jensen RA.	Microbiol Mol Biol Rev	10.1128/mmbr.00024-09	2009
Metabolism	Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms.	Yamada Y, Komatsu M, Ikeda H	J Antibiot (Tokyo)	10.1038/ja.2015.147	2016
Metabolism	Screening of wild type Streptomyces isolates able to overproduce clavulanic acid.	Viana Marques DA, Santos-Ebinuma Vde C, de Oliveira PM, Lima GM, Araujo JM, Lima-Filho JL, Converti A, Pessoa-Junior A, Porto AL	Braz J Microbiol	10.1590/s1517-83822014000300022	2014
Phylogeny	Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.	Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner G	EMBO J	10.1002/j.1460-2075.1990.tb08168.x	1990
Metabolism	Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.	Reading C, Cole M	Antimicrob Agents Chemother	10.1128/AAC.11.5.852	1977
Biotechnology	Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064.	Patino LF, Aguirre-Hoyos V, Pinilla LI, Toro LF, Rios-Estepa R	Bioengineering (Basel)	10.3390/bioengineering9020078	2022
Genetics	Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064.	Pivk Lukancic P, Drcar T, Bruccoleri R, Crnugelj M, Mrak P	Appl Microbiol Biotechnol	10.1007/s00253-022-11805-5	2022
	Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus.	Gomez-Escribano JP, Algora Gallardo L, Bozhuyuk KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B	Microb Genom	10.1099/mgen.0.000669	2021
	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.	Hwang S, Lee N, Choe D, Lee Y, Kim W, Jeong Y, Cho S, Palsson BO, Cho BK	mSystems	10.1128/mSystems.01013-20	2021
Metabolism	Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus.	Unsaldi E, Kurt-Kizildogan A, Ozcan S, Becher D, Voigt B, Aktas C, Ozcengiz G	Protein Pept Lett	10.2174/0929866527666200723163655	2021
	The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1.	Fu J, Qin R, Zong G, Zhong C, Zhang P, Kang N, Qi X, Cao G	AMB Express	10.1186/s13568-019-0844-z	2019
Transcriptome	Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions.	Pinilla L, Toro LF, Laing E, Alzate JF, Rios-Estepa R	Antibiotics (Basel)	10.3390/antibiotics8030096	2019
	Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.	Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P	Front Microbiol	10.3389/fmicb.2019.00580	2019
	A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications.	Ayala-Ruano S, Santander-Gordon D, Tejera E, Perez-Castillo Y, Armijos-Jaramillo V	Ecol Evol	10.1002/ece3.4924	2019
Metabolism	The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1.	Fu J, Qin R, Zong G, Liu C, Kang N, Zhong C, Cao G	Front Microbiol	10.3389/fmicb.2019.00244	2019
	Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1.	Li J, Zhao Z, Zhong W, Zhong C, Zong G, Fu J, Cao G	3 Biotech	10.1007/s13205-018-1498-2	2018
Metabolism	Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.	Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Martin JF, Liras P	Appl Environ Microbiol	10.1128/AEM.01701-18	2018
Genetics	Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor.	Li S, Wang W, Li X, Fan K, Yang K	Sci Rep	10.1038/srep15840	2015
	A method for investigating the stereochemical course of terpene cyclisations.	Rabe P, Rinkel J, Klapschinski TA, Barra L, Dickschat JS	Org Biomol Chem	10.1039/c5ob01998b	2016
Metabolism	The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.	Martinez-Burgo Y, Alvarez-Alvarez R, Rodriguez-Garcia A, Liras P	Appl Environ Microbiol	10.1128/AEM.00916-15	2015
Metabolism	Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster.	Martinez-Burgo Y, Alvarez-Alvarez R, Perez-Redondo R, Liras P	J Biotechnol	10.1016/j.jbiotec.2014.06.002	2014
Metabolism	Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.	da Silva Vasconcelos E, de Lima VA, Goto LS, Cruz-Hernandez IL, Hokka CO	Braz J Microbiol	10.1590/S1517-83822014005000005	2014
Metabolism	Transcriptomic analysis of Streptomyces clavuligerus DeltaccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.	Alvarez-Alvarez R, Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Prieto-Dominguez A, Martinez-Burgo Y, Liras P	Microb Biotechnol	10.1111/1751-7915.12109	2014
Metabolism	Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.	Liras P	Appl Microbiol Biotechnol	10.1007/s00253-013-5410-z	2013
Metabolism	Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus.	Guo D, Zhao Y, Yang K	Sci China Life Sci	10.1007/s11427-013-4507-z	2013
Metabolism	Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.	Robles-Reglero V, Santamarta I, Alvarez-Alvarez R, Martin JF, Liras P	J Biotechnol	10.1016/j.jbiotec.2012.09.017	2012
Metabolism	Prediction of the pho regulon in Streptomyces clavuligerus DSM 738.	Salehghamari E, Hamedi J, Elahi E, Sepehrizadeh Z, Sadeghi M, Muth G	New Microbiol		2012
Phylogeny	Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus , PTCC 1709.	Hojati Z, Salehi Z, Motovali-Bashi M, Korbekandi H, Jami S	Cell J		2011
Metabolism	Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.	Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, Martin JF, Liras P	Mol Microbiol	10.1111/j.1365-2958.2011.07743.x	2011
Metabolism	A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.	Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras P	Microb Biotechnol	10.1111/j.1751-7915.2010.00222.x	2010
Metabolism	Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.	Ozcengiz G, Okay S, Unsaldi E, Taskin B, Liras P, Piret J	Bioeng Bugs	10.4161/bbug.1.3.11244	2010
Enzymology	Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.	Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z	Protein Cell	10.1007/s13238-010-0127-6	2010
Metabolism	Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.	Li B, Walsh CT	Proc Natl Acad Sci U S A	10.1073/pnas.1014140107	2010
Genetics	Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.	Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF	J Bacteriol	10.1128/JB.00859-10	2010
Enzymology	Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production.	Kanth BK, Jnawali HN, Niraula NP, Sohng JK	Microbiol Res	10.1016/j.micres.2010.07.003	2010
Metabolism	Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585.	Jnawali HN, Liou K, Sohng JK	Microbiol Res	10.1016/j.micres.2010.07.005	2010
Genetics	The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.	Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Muller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E	Genome Biol Evol	10.1093/gbe/evq013	2010
Biotechnology	Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus.	Korbekandi H, Darkhal P, Hojati Z, Abedi D, Hamedi J, Pourhosein M	Iran J Pharm Res		2010
Metabolism	Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585.	Jnawali HN, Lee HC, Sohng JK	J Microbiol Biotechnol	JMB020-01-20	2010
Metabolism	[Evaluation of the activities of two promoters in Streptomycetes by reporter gene method].	Li J, Xiang S, Yang X, Yang K	Wei Sheng Wu Xue Bao		2009
Metabolism	The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.	Perez-Redondo R, Santamarta I, Bovenberg R, Martin JF, Liras P	Microbiology (Reading)	10.1099/mic.0.035840-0	2010
Metabolism	Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.	Liras P, Demain AL	Methods Enzymol	10.1016/S0076-6879(09)04816-2	2009
Metabolism	Glycerol utilization gene cluster in Streptomyces clavuligerus.	Banos S, Perez-Redondo R, Koekman B, Liras P	Appl Environ Microbiol	10.1128/AEM.00181-09	2009
Genetics	A two-component regulatory system involved in clavulanic acid production.	Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JK	J Antibiot (Tokyo)	10.1038/ja.2008.92	2008
Metabolism	An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.	Kim SJ, Kim JO, Shin CH, Park HW, Kim CW	Biosci Biotechnol Biochem	10.1271/bbb.80569	2009
Biotechnology	A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.	Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ	J Ind Microbiol Biotechnol	10.1007/s10295-008-0499-2	2008
Metabolism	Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064.	Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ	J Microbiol Biotechnol	7169	2008
Metabolism	Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585.	Hung TV, Malla S, Park BC, Liou K, Lee HC, Sohng JK	J Microbiol Biotechnol		2007
Enzymology	Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus.	Yilmaz EI, Caydasi AK, Ozcengiz G	J Ind Microbiol Biotechnol	10.1007/s10295-007-0259-8	2007
Metabolism	Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.	Santamarta I, Lopez-Garcia MT, Perez-Redondo R, Koekman B, Martin JF, Liras P	Mol Microbiol	10.1111/j.1365-2958.2007.05937.x	2007
Metabolism	A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142.	Saudagar PS, Singhal RS	Appl Biochem Biotechnol	10.1007/s12010-007-9030-x	2007
Genetics	Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus.	Wu W, Leblanc SK, Piktel J, Jensen SE, Roy KL	Can J Microbiol	10.1139/w05-126	2006
Metabolism	Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064.	Jin W, Kim HK, Kim JY, Kang SG, Lee SH, Lee KJ	J Biotechnol	10.1016/j.jbiotec.2004.06.010	2004
Enzymology	Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus.	Tunca S, Yilmaz EI, Piret J, Liras P, Ozcengiz G	Res Microbiol	10.1016/j.resmic.2004.03.007	2004
Metabolism	CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.	Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, Martin JF, Liras P	J Bacteriol	10.1128/JB.184.11.3106-3113.2002	2002
Enzymology	Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585.	Soh BS, Loke P, Sim TS	Biochim Biophys Acta	10.1016/s0167-4781(01)00309-8	2001
Enzymology	Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate.	Chan M, Sim TS	Microbiology (Reading)	10.1099/00221287-144-11-3229	1998
Metabolism	Lysine epsilon-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes.	Rius N, Demain AL	J Microbiol Biotechnol		1997
Metabolism	Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture.	Cochet N, Demain AL	J Appl Bacteriol	10.1111/j.1365-2672.1996.tb03228.x	1996
Genetics	Giant linear plasmids of beta-lactam antibiotic producing Streptomyces.	Netolitzky DJ, Wu X, Jensen SE, Roy KL	FEMS Microbiol Lett	10.1016/0378-1097(95)00230-3	1995
Enzymology	Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans.	Xiao X, Hintermann G, Hausler A, Barker PJ, Foor F, Demain AL, Piret J	Antimicrob Agents Chemother	10.1128/AAC.37.1.84	1993
Metabolism	Characterization of an inducible transport system for glycerol in Streptomyces clavuligerus. Repression by L-serine.	Minambres B, Reglero A, Luengo JM	J Antibiot (Tokyo)	10.7164/antibiotics.45.269	1992
Enzymology	Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis.	Salowe SP, Marsh EN, Townsend CA	Biochemistry	10.1021/bi00479a023	1990
Enzymology	Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585.	Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain AL	Appl Microbiol Biotechnol	10.1007/BF00173728	1990
Enzymology	Regulation of ACV synthetase: biosynthesis and action.	Zhang JY, Demain AL	Chin J Biotechnol		1990
Enzymology	Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.	Rollins MJ, Jensen SE, Wolfe S, Westlake DW	Enzyme Microb Technol	10.1016/0141-0229(90)90178-s	1990
Metabolism	Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant.	Garcia-Dominguez M, Martin JF, Liras P	J Bacteriol	10.1128/jb.171.12.6808-6814.1989	1989
Metabolism	Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium.	Jermini MF, Demain AL	Experientia	10.1007/BF01950159	1989
Enzymology	Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.	Pruess DL, Kellett M	J Antibiot (Tokyo)	10.7164/antibiotics.36.208	1983
Metabolism	High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus.	Jensen SE, Westlake DW, Wolfe S	J Antibiot (Tokyo)	10.7164/antibiotics.35.1026	1982
Metabolism	Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585.	Zhang C, Zhao Y, Li Z, Wang W, Huang Y, Pan G, Fan K	Front Microbiol	10.3389/fmicb.2022.1078293	2022
Proteome	An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.	Kurt-Kizildogan A, Celik G, Unsaldi E, Ozcan S, Ayaz-Guner S, Ozcengiz G	Appl Microbiol Biotechnol	10.1007/s00253-022-12098-4	2022
Phylogeny	Streptomyces yaizuensis sp. nov., a berninamycin C-producing actinomycete isolated from sponge.	Takahashi M, Hoshino K, Hamada M, Tamura T, Moriuchi R, Dohra H, Nakagawa Y, Kokubo S, Yamazaki M, Nakagawa H, Hayakawa M, Kodani S, Yamamura H.	J Antibiot (Tokyo)	10.1038/s41429-024-00782-8	2025
Biotechnology	Discovery of Streptomyces marinisediminis sp. nov., a new thiolutin producing actinomycete isolated from Thai marine sediment	Pansomsuay R, Fukasem P, Pittayakhajonwut P, Intaraudom C, Suriyachadkun C, Yasawong M, He Y, Tanasupawat S, Qian Y, Thawai C.	Sci Rep		2025
Genetics	Description of Streptomyces naphthomycinicus sp. nov., an endophytic actinobacterium producing naphthomycin A and its genome insight for discovering bioactive compounds.	Kaewkla O, Perkins M, Thamchaipenet A, Saijuntha W, Sukpanoa S, Suriyachadkun C, Chamroensaksri N, Chumroenphat T, Franco CMM.	Front Microbiol	10.3389/fmicb.2024.1353511	2024