Name: Streptomyces clavuligerus DSM 738
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 15101

Type strain:

Species: Streptomyces clavuligerus

Culture col. no.: DSM 738, ATCC 27064, DSM 41253, NRRL 3585, BCRC 11518, CBS 226.75, CCRC 11518, CECT 3125, CGMCC 4.1611, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, VKM Ac-602, DSM 40751, MTCC 1142, NBIMCC 3333, NCIMB 14335

Strain history: KCC S-0710 <-- Tanabe Seiyaku Co., Ltd., Japan; MCRL 0774 <-- NRRL 3585 <-- Eli Lilly & Co., USA.

NCBI tax ID(s): 1901 (species)

SI-ID 125802

ATCC 27064, NRRL 3585, DSM 738, DSM 41253, JCM 4710, CCRC 11518, DSM 40751, IFO 13307, IMET 43657, NCIMB 12785, VKM Ac-602, NRRL B-3585, CBS 226.75, CECT 3125, CCRC 27064, KCTC 9095, AS 4.1611, NBRC 13307, BCRC 11518, NBIMCC 3333, CDBB 1238, CGMCC 4.1611

Other strains from Streptomyces clavuligerus

S. clavuligerus 21, H6458, DSM 41826, JCM 10034
S. clavuligerus ST029356(HKI), Wirt IMET10348,
S. clavuligerus Leon_Sclav_2005, DSM 112468

Section

Streptomyces clavuligerus DSM 738 is a spore-forming, mesophilic bacterium that was isolated from soil.

spore-forming
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	14-12-2023 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Actinomycetota*
	Class	*Actinomycetes*
	Order	*Kitasatosporales*
	Family	*Streptomycetaceae*
	Genus	*Streptomyces*
	Species	**Streptomyces clavuligerus**
	Full Scientific Name (LPSN)	Streptomyces clavuligerus Higgens and Kastner 1971 (Approved Lists 1980)

Information on morphological and physiological properties Morphology

[Ref.: #69480]	Gram stain	positive Confidence in %100

[Ref.: #69480]	Motility	no Confidence in %93.965

Multimedia content

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Intellectual property rights:

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Caption:

Medium 65 28°C

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Intellectual property rights:

Information on culture and growth conditions Culture and growth conditions

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Culture medium

GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

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Culture medium

BENNETT'S AGAR (DSMZ Medium 548)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

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Culture medium

NUTRIENT AGAR (DSMZ Medium 1)

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Culture medium growth

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Culture medium link

Medium recipe at MediaDive

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Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #381]			growth	28 °C
[Ref.: #67770]			growth	28 °C

[Ref.: #381]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

[Ref.: #69481]	Ability of spore formation	yes Confidence in %100
[Ref.: #69480]	Ability of spore formation	yes Confidence in %100

[Ref.: #381]	Name of produced compound	peniclllin N
[Ref.: #381]	Name of produced compound	benzylpenicillin
[Ref.: #381]	Name of produced compound	clavulanic acid
[Ref.: #20216]	Name of produced compound	Clavulansäure
[Ref.: #20216]	Name of produced compound	Cephalosporine
[Ref.: #20216]	Name of produced compound	Penizilline

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Observation

quinones: MK-9(H₈), MK-9(H₆)

	Metabolite	Production
[Ref.: #67770]	cephalosporin ChEBI	yes
[Ref.: #67770]	clavulanate ChEBI	yes
[Ref.: #67770]	penicillin N ChEBI	yes

	Pathway	Enzyme coverage	Annotated reactions
	Pathway annotation	Computationally determined by
[Ref.: #66794]	molybdenum cofactor biosynthesis	100	9 of 9
[Ref.: #66794]	pentose phosphate pathway	100	11 of 11
[Ref.: #66794]	aminopropanol phosphate biosynthesis	100	2 of 2
[Ref.: #66794]	phenylacetate degradation (aerobic)	100	5 of 5
[Ref.: #66794]	glycogen metabolism	100	5 of 5
[Ref.: #66794]	biotin biosynthesis	100	4 of 4
[Ref.: #66794]	daunorubicin biosynthesis	100	9 of 9
[Ref.: #66794]	starch degradation	100	10 of 10
[Ref.: #66794]	ribulose monophosphate pathway	100	2 of 2
[Ref.: #66794]	kanosamine biosynthesis II	100	2 of 2
[Ref.: #66794]	palmitate biosynthesis	100	22 of 22
[Ref.: #66794]	ethanol fermentation	100	2 of 2
[Ref.: #66794]	cardiolipin biosynthesis	100	7 of 7
[Ref.: #66794]	threonine metabolism	100	10 of 10
[Ref.: #66794]	cis-vaccenate biosynthesis	100	2 of 2
[Ref.: #66794]	adipate degradation	100	2 of 2
[Ref.: #66794]	myo-inositol biosynthesis	100	10 of 10
[Ref.: #66794]	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
[Ref.: #66794]	acetate fermentation	100	4 of 4
[Ref.: #66794]	metabolism of amino sugars and derivatives	100	5 of 5
[Ref.: #66794]	suberin monomers biosynthesis	100	2 of 2
[Ref.: #66794]	aerobactin biosynthesis	100	1 of 1
[Ref.: #66794]	taurine degradation	100	1 of 1
[Ref.: #66794]	anapleurotic synthesis of oxalacetate	100	1 of 1
[Ref.: #66794]	aspartate and asparagine metabolism	100	9 of 9
[Ref.: #66794]	butanoate fermentation	100	4 of 4
[Ref.: #66794]	UDP-GlcNAc biosynthesis	100	3 of 3
[Ref.: #66794]	valine metabolism	100	9 of 9
[Ref.: #66794]	CDP-diacylglycerol biosynthesis	100	2 of 2
[Ref.: #66794]	coenzyme A metabolism	100	4 of 4
[Ref.: #66794]	methylglyoxal degradation	100	5 of 5
[Ref.: #66794]	lipoate biosynthesis	100	5 of 5
[Ref.: #66794]	ceramide biosynthesis	100	1 of 1
[Ref.: #66794]	formaldehyde oxidation	100	3 of 3
[Ref.: #66794]	glycine betaine biosynthesis	100	5 of 5
[Ref.: #66794]	ppGpp biosynthesis	100	4 of 4
[Ref.: #66794]	folate polyglutamylation	100	1 of 1
[Ref.: #66794]	citric acid cycle	92.86	13 of 14
[Ref.: #66794]	leucine metabolism	92.31	12 of 13
[Ref.: #66794]	phenylalanine metabolism	92.31	12 of 13
[Ref.: #66794]	vitamin B12 metabolism	91.18	31 of 34
[Ref.: #66794]	propionate fermentation	90	9 of 10
[Ref.: #66794]	serine metabolism	88.89	8 of 9
[Ref.: #66794]	4-hydroxymandelate degradation	88.89	8 of 9
[Ref.: #66794]	NAD metabolism	88.89	16 of 18
[Ref.: #66794]	CO2 fixation in Crenarchaeota	88.89	8 of 9
[Ref.: #66794]	gluconeogenesis	87.5	7 of 8
[Ref.: #66794]	C4 and CAM-carbon fixation	87.5	7 of 8
[Ref.: #66794]	peptidoglycan biosynthesis	86.67	13 of 15
[Ref.: #66794]	photosynthesis	85.71	12 of 14
[Ref.: #66794]	glutamate and glutamine metabolism	85.71	24 of 28
[Ref.: #66794]	ubiquinone biosynthesis	85.71	6 of 7
[Ref.: #66794]	propanol degradation	85.71	6 of 7
[Ref.: #66794]	lipid metabolism	83.87	26 of 31
[Ref.: #66794]	glycolate and glyoxylate degradation	83.33	5 of 6
[Ref.: #66794]	arginine metabolism	83.33	20 of 24
[Ref.: #66794]	alanine metabolism	82.76	24 of 29
[Ref.: #66794]	glycolysis	82.35	14 of 17
[Ref.: #66794]	metabolism of disaccharids	81.82	9 of 11
[Ref.: #66794]	degradation of sugar alcohols	81.25	13 of 16
[Ref.: #66794]	isoprenoid biosynthesis	80.77	21 of 26
[Ref.: #66794]	methionine metabolism	80.77	21 of 26
[Ref.: #66794]	cellulose degradation	80	4 of 5
[Ref.: #66794]	Entner Doudoroff pathway	80	8 of 10
[Ref.: #66794]	flavin biosynthesis	80	12 of 15
[Ref.: #66794]	factor 420 biosynthesis	80	4 of 5
[Ref.: #66794]	ethylmalonyl-CoA pathway	80	4 of 5
[Ref.: #66794]	4-hydroxyphenylacetate degradation	80	8 of 10
[Ref.: #66794]	heme metabolism	78.57	11 of 14
[Ref.: #66794]	glutathione metabolism	78.57	11 of 14
[Ref.: #66794]	chorismate metabolism	77.78	7 of 9
[Ref.: #66794]	allantoin degradation	77.78	7 of 9
[Ref.: #66794]	d-mannose degradation	77.78	7 of 9
[Ref.: #66794]	purine metabolism	77.66	73 of 94
[Ref.: #66794]	urea cycle	76.92	10 of 13
[Ref.: #66794]	vitamin B1 metabolism	76.92	10 of 13
[Ref.: #66794]	histidine metabolism	75.86	22 of 29
[Ref.: #66794]	pyrimidine metabolism	75.56	34 of 45
[Ref.: #66794]	isoleucine metabolism	75	6 of 8
[Ref.: #66794]	sulfopterin metabolism	75	3 of 4
[Ref.: #66794]	glycogen biosynthesis	75	3 of 4
[Ref.: #66794]	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
[Ref.: #66794]	cyclohexanol degradation	75	3 of 4
[Ref.: #66794]	polyamine pathway	73.91	17 of 23
[Ref.: #66794]	tryptophan metabolism	73.68	28 of 38
[Ref.: #66794]	cholesterol biosynthesis	72.73	8 of 11
[Ref.: #66794]	proline metabolism	72.73	8 of 11
[Ref.: #66794]	cysteine metabolism	72.22	13 of 18
[Ref.: #66794]	degradation of sugar acids	72	18 of 25
[Ref.: #66794]	aclacinomycin biosynthesis	71.43	5 of 7
[Ref.: #66794]	tyrosine metabolism	71.43	10 of 14
[Ref.: #66794]	lysine metabolism	69.05	29 of 42
[Ref.: #66794]	acetyl CoA biosynthesis	66.67	2 of 3
[Ref.: #66794]	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
[Ref.: #66794]	octane oxidation	66.67	2 of 3
[Ref.: #66794]	IAA biosynthesis	66.67	2 of 3
[Ref.: #66794]	L-lactaldehyde degradation	66.67	2 of 3
[Ref.: #66794]	acetoin degradation	66.67	2 of 3
[Ref.: #66794]	cyanate degradation	66.67	2 of 3
[Ref.: #66794]	(5R)-carbapenem carboxylate biosynthesis	66.67	2 of 3
[Ref.: #66794]	non-pathway related	65.79	25 of 38
[Ref.: #66794]	oxidative phosphorylation	64.84	59 of 91
[Ref.: #66794]	tetrahydrofolate metabolism	64.29	9 of 14
[Ref.: #66794]	androgen and estrogen metabolism	62.5	10 of 16
[Ref.: #66794]	dTDPLrhamnose biosynthesis	62.5	5 of 8
[Ref.: #66794]	ketogluconate metabolism	62.5	5 of 8
[Ref.: #66794]	degradation of pentoses	60.71	17 of 28
[Ref.: #66794]	arachidonate biosynthesis	60	3 of 5
[Ref.: #66794]	glycine metabolism	60	6 of 10
[Ref.: #66794]	gallate degradation	60	3 of 5
[Ref.: #66794]	reductive acetyl coenzyme A pathway	57.14	4 of 7
[Ref.: #66794]	phenol degradation	55	11 of 20
[Ref.: #66794]	sulfate reduction	53.85	7 of 13
[Ref.: #66794]	phenylpropanoid biosynthesis	53.85	7 of 13
[Ref.: #66794]	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
[Ref.: #66794]	vitamin E metabolism	50	2 of 4
[Ref.: #66794]	pantothenate biosynthesis	50	3 of 6
[Ref.: #66794]	carotenoid biosynthesis	50	11 of 22
[Ref.: #66794]	toluene degradation	50	2 of 4
[Ref.: #66794]	mannosylglycerate biosynthesis	50	1 of 2
[Ref.: #66794]	lactate fermentation	50	2 of 4
[Ref.: #66794]	quinate degradation	50	1 of 2
[Ref.: #66794]	resorcinol degradation	50	1 of 2
[Ref.: #66794]	grixazone biosynthesis	50	1 of 2
[Ref.: #66794]	degradation of hexoses	50	9 of 18
[Ref.: #66794]	carnitine metabolism	50	4 of 8
[Ref.: #66794]	bile acid biosynthesis, neutral pathway	47.06	8 of 17
[Ref.: #66794]	vitamin B6 metabolism	45.45	5 of 11
[Ref.: #66794]	lipid A biosynthesis	44.44	4 of 9
[Ref.: #66794]	benzoyl-CoA degradation	42.86	3 of 7
[Ref.: #66794]	ascorbate metabolism	40.91	9 of 22
[Ref.: #66794]	3-chlorocatechol degradation	40	2 of 5
[Ref.: #66794]	vitamin K metabolism	40	2 of 5
[Ref.: #66794]	coenzyme M biosynthesis	40	4 of 10
[Ref.: #66794]	3-phenylpropionate degradation	40	6 of 15
[Ref.: #66794]	bacilysin biosynthesis	40	2 of 5
[Ref.: #66794]	hydrogen production	40	2 of 5
[Ref.: #66794]	D-cycloserine biosynthesis	40	2 of 5
[Ref.: #66794]	O-antigen biosynthesis	40	2 of 5
[Ref.: #66794]	arachidonic acid metabolism	38.89	7 of 18
[Ref.: #66794]	d-xylose degradation	36.36	4 of 11
[Ref.: #66794]	enterobactin biosynthesis	33.33	1 of 3
[Ref.: #66794]	sulfoquinovose degradation	33.33	1 of 3
[Ref.: #66794]	sphingosine metabolism	33.33	2 of 6
[Ref.: #66794]	nitrate assimilation	33.33	3 of 9
[Ref.: #66794]	methanogenesis from CO2	33.33	4 of 12
[Ref.: #66794]	selenocysteine biosynthesis	33.33	2 of 6
[Ref.: #66794]	phosphatidylethanolamine bioynthesis	30.77	4 of 13
[Ref.: #66794]	mevalonate metabolism	28.57	2 of 7
[Ref.: #66794]	chlorophyll metabolism	27.78	5 of 18
[Ref.: #66794]	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
[Ref.: #66794]	CMP-KDO biosynthesis	25	1 of 4
[Ref.: #66794]	alginate biosynthesis	25	1 of 4
[Ref.: #66794]	catecholamine biosynthesis	25	1 of 4
		Only first 10 entries are displayed. Click here to see all.

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #381]	Sample type/isolated from	soil

[Ref.: #67770]	Sample type/isolated from	Soil
[Ref.: #67770]	Country	South America
* marker position based on {}

Isolation sources categories

#Environmental

#Terrestrial

#Soil

What are isolation sources categories?

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #381]

Biosafety level

Risk group (German classification)
According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #20218]	Streptomyces clavuligerus gene for 16S rRNA, partial sequence	AB122716	564	ENA	443255 tax ID	*
[Ref.: #20218]	Streptomyces clavuligerus gene for 16S rRNA	AB045869	1486	ENA	443255 tax ID	*
[Ref.: #20218]	Streptomyces clavuligerus gene for 16S rRNA, partial sequence, strain: NBRC 13307	AB184343	1462	ENA	443255 tax ID	*
[Ref.: #20218]	Streptomyces clavuligerus 16S ribosomal RNA gene, partial sequence	AF417600	356	ENA	443255 tax ID	*
[Ref.: #20218]	Streptomyces clavuligerus ATCC 27064 strain NRRL 3585 16S ribosomal RNA gene, partial sequence	AY999718	1448	ENA	443255 tax ID	*

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level	Sequence database	Associated NCBI tax ID
[Ref.: #67770]	Streptomyces clavuligerus ATCC 27064	GCA_000154925	scaffold	GenBank	1901 tax ID
[Ref.: #66792]	Streptomyces clavuligerus DSM 738	GCA_028752555	complete	GenBank	1901 tax ID	*
[Ref.: #66792]	Streptomyces clavuligerus ATCC 27064	GCA_000148465	chromosome	GenBank	1901 tax ID	*
[Ref.: #66792]	Streptomyces clavuligerus ATCC 27064	GCA_000163875	chromosome	GenBank	1901 tax ID	*
[Ref.: #66792]	Streptomyces clavuligerus ATCC 27064	GCA_015912395	contig	GenBank	1901 tax ID	*
[Ref.: #66792]	Streptomyces clavuligerus DSM 738	GCA_015912875	contig	GenBank	1901 tax ID	*

[Ref.: #67770]

GC-content

72.5 mol%

genome sequence analysis

Data predicted using genome information as a basis Genome-based predictions

	Trait	Prediction	Confidence in %	In training data
	Predictions from GenomeNet Sporulation v. 1 based on: Streptomyces clavuligerus strain ATCC 27064 PATRIC: 1901.22
[Ref.: #69481]	spore-forming	yes	100	no

	Trait	Prediction	Confidence in %	In training data
	Predictions from Diaspora project based on: Streptomyces clavuligerus ATCC 27064 NCBI: GCA_005519465.1
[Ref.: #69480]	motile	no	93.286	no
[Ref.: #69480]	flagellated	no	97.589	no
[Ref.: #69480]	gram-positive	yes	87.12	no
[Ref.: #69480]	anaerobic	no	98.831	no
[Ref.: #69480]	aerobic	yes	92.124	no
[Ref.: #69480]	halophile	no	94.157	no
[Ref.: #69480]	spore-forming	yes	92.716	no
[Ref.: #69480]	glucose-util	yes	89.456	no
[Ref.: #69480]	thermophile	no	96.08	no
[Ref.: #69480]	glucose-ferment	no	91.485	no

Availability in culture collections External links

[Ref.: #381]

Culture collection no.

DSM 738, ATCC 27064, DSM 41253, NRRL 3585, BCRC 11518, CBS 226.75, CCRC 11518, CECT 3125, CGMCC 4.1611, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, VKM Ac-602, DSM 40751, MTCC 1142, NBIMCC 3333, NCIMB 14335

[Ref.: #84208]

SI-ID 125802

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms.	Yamada Y, Komatsu M, Ikeda H	J Antibiot (Tokyo)	10.1038/ja.2015.147	2016	*
Metabolism	Screening of wild type Streptomyces isolates able to overproduce clavulanic acid.	Viana Marques DA, Santos-Ebinuma Vde C, de Oliveira PM, Lima GM, Araujo JM, Lima-Filho JL, Converti A, Pessoa-Junior A, Porto AL	Braz J Microbiol	10.1590/s1517-83822014000300022	2014	*
Phylogeny	Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.	Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner G	EMBO J	10.1002/j.1460-2075.1990.tb08168.x	1990	*
Metabolism	Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.	Reading C, Cole M	Antimicrob Agents Chemother	10.1128/AAC.11.5.852	1977	*
Biotechnology	Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064.	Patino LF, Aguirre-Hoyos V, Pinilla LI, Toro LF, Rios-Estepa R	Bioengineering (Basel)	10.3390/bioengineering9020078	2022	*
Genetics	Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064.	Pivk Lukancic P, Drcar T, Bruccoleri R, Crnugelj M, Mrak P	Appl Microbiol Biotechnol	10.1007/s00253-022-11805-5	2022	*
Metabolism	Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus.	Unsaldi E, Kurt-Kizildogan A, Ozcan S, Becher D, Voigt B, Aktas C, Ozcengiz G	Protein Pept Lett	10.2174/0929866527666200723163655	2021	*
Transcriptome	Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions.	Pinilla L, Toro LF, Laing E, Alzate JF, Rios-Estepa R	Antibiotics (Basel)	10.3390/antibiotics8030096	2019	*
Metabolism	The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1.	Fu J, Qin R, Zong G, Liu C, Kang N, Zhong C, Cao G	Front Microbiol	10.3389/fmicb.2019.00244	2019	*
Metabolism	Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.	Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Martin JF, Liras P	Appl Environ Microbiol	10.1128/AEM.01701-18	2018	*
Genetics	Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor.	Li S, Wang W, Li X, Fan K, Yang K	Sci Rep	10.1038/srep15840	2015	*
Metabolism	The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.	Martinez-Burgo Y, Alvarez-Alvarez R, Rodriguez-Garcia A, Liras P	Appl Environ Microbiol	10.1128/AEM.00916-15	2015	*
Metabolism	Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster.	Martinez-Burgo Y, Alvarez-Alvarez R, Perez-Redondo R, Liras P	J Biotechnol	10.1016/j.jbiotec.2014.06.002	2014	*
Metabolism	Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.	da Silva Vasconcelos E, de Lima VA, Goto LS, Cruz-Hernandez IL, Hokka CO	Braz J Microbiol	10.1590/S1517-83822014005000005	2014	*
Metabolism	Transcriptomic analysis of Streptomyces clavuligerus DeltaccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.	Alvarez-Alvarez R, Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Prieto-Dominguez A, Martinez-Burgo Y, Liras P	Microb Biotechnol	10.1111/1751-7915.12109	2014	*
Metabolism	Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.	Liras P	Appl Microbiol Biotechnol	10.1007/s00253-013-5410-z	2013	*
Metabolism	Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus.	Guo D, Zhao Y, Yang K	Sci China Life Sci	10.1007/s11427-013-4507-z	2013	*
Metabolism	Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.	Robles-Reglero V, Santamarta I, Alvarez-Alvarez R, Martin JF, Liras P	J Biotechnol	10.1016/j.jbiotec.2012.09.017	2012	*
Metabolism	Prediction of the pho regulon in Streptomyces clavuligerus DSM 738.	Salehghamari E, Hamedi J, Elahi E, Sepehrizadeh Z, Sadeghi M, Muth G	New Microbiol		2012	*
Phylogeny	Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus , PTCC 1709.	Hojati Z, Salehi Z, Motovali-Bashi M, Korbekandi H, Jami S	Cell J		2011	*
Metabolism	Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.	Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, Martin JF, Liras P	Mol Microbiol	10.1111/j.1365-2958.2011.07743.x	2011	*
Metabolism	A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.	Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras P	Microb Biotechnol	10.1111/j.1751-7915.2010.00222.x	2010	*
Metabolism	Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.	Ozcengiz G, Okay S, Unsaldi E, Taskin B, Liras P, Piret J	Bioeng Bugs	10.4161/bbug.1.3.11244	2010	*
Enzymology	Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.	Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z	Protein Cell	10.1007/s13238-010-0127-6	2010	*
Metabolism	Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.	Li B, Walsh CT	Proc Natl Acad Sci U S A	10.1073/pnas.1014140107	2010	*
Genetics	Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.	Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF	J Bacteriol	10.1128/JB.00859-10	2010	*
Enzymology	Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production.	Kanth BK, Jnawali HN, Niraula NP, Sohng JK	Microbiol Res	10.1016/j.micres.2010.07.003	2010	*
Metabolism	Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585.	Jnawali HN, Liou K, Sohng JK	Microbiol Res	10.1016/j.micres.2010.07.005	2010	*
Genetics	The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.	Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Muller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E	Genome Biol Evol	10.1093/gbe/evq013	2010	*
Biotechnology	Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus.	Korbekandi H, Darkhal P, Hojati Z, Abedi D, Hamedi J, Pourhosein M	Iran J Pharm Res		2010	*
Metabolism	Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585.	Jnawali HN, Lee HC, Sohng JK	J Microbiol Biotechnol	JMB020-01-20	2010	*
Metabolism	[Evaluation of the activities of two promoters in Streptomycetes by reporter gene method].	Li J, Xiang S, Yang X, Yang K	Wei Sheng Wu Xue Bao		2009	*
Metabolism	The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.	Perez-Redondo R, Santamarta I, Bovenberg R, Martin JF, Liras P	Microbiology (Reading)	10.1099/mic.0.035840-0	2010	*
Metabolism	Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.	Liras P, Demain AL	Methods Enzymol	10.1016/S0076-6879(09)04816-2	2009	*
Metabolism	Glycerol utilization gene cluster in Streptomyces clavuligerus.	Banos S, Perez-Redondo R, Koekman B, Liras P	Appl Environ Microbiol	10.1128/AEM.00181-09	2009	*
Genetics	A two-component regulatory system involved in clavulanic acid production.	Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JK	J Antibiot (Tokyo)	10.1038/ja.2008.92	2008	*
Metabolism	An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.	Kim SJ, Kim JO, Shin CH, Park HW, Kim CW	Biosci Biotechnol Biochem	10.1271/bbb.80569	2009	*
Biotechnology	A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.	Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ	J Ind Microbiol Biotechnol	10.1007/s10295-008-0499-2	2008	*
Metabolism	Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064.	Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ	J Microbiol Biotechnol	7169	2008	*
Metabolism	Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585.	Hung TV, Malla S, Park BC, Liou K, Lee HC, Sohng JK	J Microbiol Biotechnol		2007	*
Enzymology	Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus.	Yilmaz EI, Caydasi AK, Ozcengiz G	J Ind Microbiol Biotechnol	10.1007/s10295-007-0259-8	2007	*
Metabolism	Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.	Santamarta I, Lopez-Garcia MT, Perez-Redondo R, Koekman B, Martin JF, Liras P	Mol Microbiol	10.1111/j.1365-2958.2007.05937.x	2007	*
Metabolism	A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142.	Saudagar PS, Singhal RS	Appl Biochem Biotechnol	10.1007/s12010-007-9030-x	2007	*
Genetics	Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus.	Wu W, Leblanc SK, Piktel J, Jensen SE, Roy KL	Can J Microbiol	10.1139/w05-126	2006	*
Metabolism	Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064.	Jin W, Kim HK, Kim JY, Kang SG, Lee SH, Lee KJ	J Biotechnol	10.1016/j.jbiotec.2004.06.010	2004	*
Enzymology	Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus.	Tunca S, Yilmaz EI, Piret J, Liras P, Ozcengiz G	Res Microbiol	10.1016/j.resmic.2004.03.007	2004	*
Metabolism	CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.	Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, Martin JF, Liras P	J Bacteriol	10.1128/JB.184.11.3106-3113.2002	2002	*
Enzymology	Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585.	Soh BS, Loke P, Sim TS	Biochim Biophys Acta	10.1016/s0167-4781(01)00309-8	2001	*
Enzymology	Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate.	Chan M, Sim TS	Microbiology (Reading)	10.1099/00221287-144-11-3229	1998	*
Metabolism	Lysine epsilon-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes.	Rius N, Demain AL	J Microbiol Biotechnol		1997	*
Metabolism	Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture.	Cochet N, Demain AL	J Appl Bacteriol	10.1111/j.1365-2672.1996.tb03228.x	1996	*
Genetics	Giant linear plasmids of beta-lactam antibiotic producing Streptomyces.	Netolitzky DJ, Wu X, Jensen SE, Roy KL	FEMS Microbiol Lett	10.1016/0378-1097(95)00230-3	1995	*
Enzymology	Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans.	Xiao X, Hintermann G, Hausler A, Barker PJ, Foor F, Demain AL, Piret J	Antimicrob Agents Chemother	10.1128/AAC.37.1.84	1993	*
Metabolism	Characterization of an inducible transport system for glycerol in Streptomyces clavuligerus. Repression by L-serine.	Minambres B, Reglero A, Luengo JM	J Antibiot (Tokyo)	10.7164/antibiotics.45.269	1992	*
Enzymology	Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis.	Salowe SP, Marsh EN, Townsend CA	Biochemistry	10.1021/bi00479a023	1990	*
Enzymology	Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585.	Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain AL	Appl Microbiol Biotechnol	10.1007/BF00173728	1990	*
Enzymology	Regulation of ACV synthetase: biosynthesis and action.	Zhang JY, Demain AL	Chin J Biotechnol		1990	*
Enzymology	Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.	Rollins MJ, Jensen SE, Wolfe S, Westlake DW	Enzyme Microb Technol	10.1016/0141-0229(90)90178-s	1990	*
Metabolism	Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant.	Garcia-Dominguez M, Martin JF, Liras P	J Bacteriol	10.1128/jb.171.12.6808-6814.1989	1989	*
Metabolism	Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium.	Jermini MF, Demain AL	Experientia	10.1007/BF01950159	1989	*
Enzymology	Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.	Pruess DL, Kellett M	J Antibiot (Tokyo)	10.7164/antibiotics.36.208	1983	*
Metabolism	High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus.	Jensen SE, Westlake DW, Wolfe S	J Antibiot (Tokyo)	10.7164/antibiotics.35.1026	1982	*
Metabolism	Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585.	Zhang C, Zhao Y, Li Z, Wang W, Huang Y, Pan G, Fan K	Front Microbiol	10.3389/fmicb.2022.1078293	2022	*
Proteome	An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.	Kurt-Kizildogan A, Celik G, Unsaldi E, Ozcan S, Ayaz-Guner S, Ozcengiz G	Appl Microbiol Biotechnol	10.1007/s00253-022-12098-4	2022	*
	Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus.	Gomez-Escribano JP, Algora Gallardo L, Bozhuyuk KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B	Microb Genom	10.1099/mgen.0.000669	2021	*
	Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.	Hwang S, Lee N, Choe D, Lee Y, Kim W, Jeong Y, Cho S, Palsson BO, Cho BK	mSystems	10.1128/mSystems.01013-20	2021	*
	The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1.	Fu J, Qin R, Zong G, Zhong C, Zhang P, Kang N, Qi X, Cao G	AMB Express	10.1186/s13568-019-0844-z	2019	*
	Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.	Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P	Front Microbiol	10.3389/fmicb.2019.00580	2019	*
	A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications.	Ayala-Ruano S, Santander-Gordon D, Tejera E, Perez-Castillo Y, Armijos-Jaramillo V	Ecol Evol	10.1002/ece3.4924	2019	*
	Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1.	Li J, Zhao Z, Zhong W, Zhong C, Zong G, Fu J, Cao G	3 Biotech	10.1007/s13205-018-1498-2	2018	*
	A method for investigating the stereochemical course of terpene cyclisations.	Rabe P, Rinkel J, Klapschinski TA, Barra L, Dickschat JS	Org Biomol Chem	10.1039/c5ob01998b	2016	*

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Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

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Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) Curators of the HKI: Collection Description Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) .

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Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

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Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

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Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )

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Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch: Predictions based on the model GenomeNet Sporulation v. 1 . ( DOI 10.21203/rs.3.rs-2527258/v1 )

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Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.: StrainInfo: A central database for resolving microbial strain identifiers . ( DOI 10.60712/SI-ID125802.1 )

* These data were automatically processed and therefore are not curated

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Streptomyces clavuligerus strain ATCC 27064

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