Strain identifier
BacDive ID: 15101
Type strain:
Species: Streptomyces clavuligerus
Strain history: KCC S-0710 <-- Tanabe Seiyaku Co., Ltd., Japan; MCRL 0774 <-- NRRL 3585 <-- Eli Lilly & Co., USA.
NCBI tax ID(s): 1901 (species)
General
@ref: 381
BacDive-ID: 15101
DSM-Number: 738
keywords: genome sequence, 16S sequence, Bacteria, spore-forming, mesophilic
description: Streptomyces clavuligerus DSM 738 is a spore-forming, mesophilic bacterium that was isolated from soil.
NCBI tax id
- NCBI tax id: 1901
- Matching level: species
strain history
@ref | history |
---|---|
381 | <- ATCC <- C.E. Higgens |
67770 | KCC S-0710 <-- Tanabe Seiyaku Co., Ltd., Japan; MCRL 0774 <-- NRRL 3585 <-- Eli Lilly & Co., USA. |
doi: 10.13145/bacdive15101.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/actinomycetota
- domain: Bacteria
- phylum: Actinomycetota
- class: Actinomycetes
- order: Kitasatosporales
- family: Streptomycetaceae
- genus: Streptomyces
- species: Streptomyces clavuligerus
- full scientific name: Streptomyces clavuligerus Higgens and Kastner 1971 (Approved Lists 1980)
@ref: 381
domain: Bacteria
phylum: Actinobacteria
class: Actinobacteria
order: Actinomycetales
family: Streptomycetaceae
genus: Streptomyces
species: Streptomyces clavuligerus
full scientific name: Streptomyces clavuligerus Higgens and Kastner 1971 emend. Nouioui et al. 2018
type strain: yes
Morphology
cell morphology
@ref | motility | confidence | gram stain |
---|---|---|---|
69480 | no | 93.965 | |
69480 | 100 | positive |
multimedia
@ref | multimedia content | intellectual property rights | caption |
---|---|---|---|
381 | https://www.dsmz.de/microorganisms/photos/DSM_738-1.jpg | © Leibniz-Institut DSMZ | |
381 | https://www.dsmz.de/microorganisms/photos/DSM_738.jpg | © Leibniz-Institut DSMZ | Medium 65 28°C |
Culture and growth conditions
culture medium
@ref | name | growth | link | composition |
---|---|---|---|---|
381 | GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) | yes | https://mediadive.dsmz.de/medium/65 | Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water |
381 | BENNETT'S AGAR (DSMZ Medium 548) | yes | https://mediadive.dsmz.de/medium/548 | Name: BENNETT'S AGAR (DSMZ Medium 548) Composition: Agar 15.0 g/l Glucose 10.0 g/l N-Z amine 2.0 g/l Yeast extract 1.0 g/l Beef extract 1.0 g/l Distilled water |
381 | NUTRIENT AGAR (DSMZ Medium 1) | yes | https://mediadive.dsmz.de/medium/1 | Name: NUTRIENT AGAR (DSMZ Medium 1) Composition: Agar 15.0 g/l Peptone 5.0 g/l Meat extract 3.0 g/l Distilled water |
culture temp
@ref | growth | type | temperature | range |
---|---|---|---|---|
381 | positive | growth | 28 | mesophilic |
67770 | positive | growth | 28 | mesophilic |
Physiology and metabolism
spore formation
@ref | spore formation | confidence |
---|---|---|
69481 | yes | 100 |
69480 | yes | 100 |
compound production
@ref | compound |
---|---|
381 | peniclllin N |
381 | benzylpenicillin |
381 | clavulanic acid |
20216 | Clavulansäure |
20216 | Cephalosporine |
20216 | Penizilline |
observation
- @ref: 67770
- observation: quinones: MK-9(H8), MK-9(H6)
metabolite production
@ref | Chebi-ID | metabolite | production |
---|---|---|---|
67770 | 23066 | cephalosporin | yes |
67770 | 487869 | clavulanate | yes |
67770 | 18203 | penicillin N | yes |
Isolation, sampling and environmental information
isolation
@ref | sample type | country |
---|---|---|
381 | soil | |
67770 | Soil | South America |
isolation source categories
- Cat1: #Environmental
- Cat2: #Terrestrial
- Cat3: #Soil
Safety information
risk assessment
- @ref: 381
- biosafety level: 1
- biosafety level comment: Risk group (German classification)
Sequence information
16S sequences
@ref | description | accession | length | database | NCBI tax ID |
---|---|---|---|---|---|
20218 | Streptomyces clavuligerus gene for 16S rRNA, partial sequence | AB122716 | 564 | ena | 443255 |
20218 | Streptomyces clavuligerus gene for 16S rRNA | AB045869 | 1486 | ena | 443255 |
20218 | Streptomyces clavuligerus gene for 16S rRNA, partial sequence, strain: NBRC 13307 | AB184343 | 1462 | ena | 443255 |
20218 | Streptomyces clavuligerus 16S ribosomal RNA gene, partial sequence | AF417600 | 356 | ena | 443255 |
20218 | Streptomyces clavuligerus ATCC 27064 strain NRRL 3585 16S ribosomal RNA gene, partial sequence | AY999718 | 1448 | ena | 443255 |
Genome sequences
@ref | description | accession | assembly level | database | NCBI tax ID |
---|---|---|---|---|---|
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_005519465 | complete | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_015708605 | complete | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_000148465 | chromosome | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_000163875 | chromosome | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_015912395 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus DSM 738 | GCA_015912875 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | GCA_015912925 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus NCIMB 12785 | GCA_015912945 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus NCIMB 14335 | GCA_015912435 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus NRRL 3585 | GCA_015912895 | contig | ncbi | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.58 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.59 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.56 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.55 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.68 | complete | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.6 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 443255.57 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 (Prj:47867) | 443255.8 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 (Prj:64411) | 443255.19 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 strain NRRL 3585 | 443255.60 | plasmid | patric | 1901 |
66792 | Streptomyces clavuligerus strain ATCC 27064 | 1901.22 | complete | patric | 1901 |
66792 | Streptomyces clavuligerus strain ATCC 27064 | 1901.34 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus strain ATCC 27064 | 1901.41 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus strain DSM 738 | 1901.38 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus strain NCIMB 12785 | 1901.40 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus strain NCIMB 14335 | 1901.35 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus strain NRRL 3585 | 1901.39 | wgs | patric | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 2582581449 | draft | img | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 2502894011 | draft | img | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 2875420249 | complete | img | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 651324105 | draft | img | 1901 |
66792 | Streptomyces clavuligerus ATCC 27064 | 647533233 | draft | img | 1901 |
67770 | Streptomyces clavuligerus ATCC 27064 | GCA_000154925 | scaffold | ncbi | 1901 |
66792 | Streptomyces clavuligerus DSM 738 | GCA_028752555 | complete | ncbi | 1901 |
GC content
- @ref: 67770
- GC-content: 72.5
- method: genome sequence analysis
Genome-based predictions
predictions
trait | prediction | confidence | training_data |
---|---|---|---|
spore-forming | yes | 100 | no |
motile | no | 93.286 | no |
flagellated | no | 97.589 | no |
gram-positive | yes | 87.12 | no |
anaerobic | no | 98.831 | no |
aerobic | yes | 92.124 | no |
halophile | no | 94.157 | no |
spore-forming | yes | 92.716 | no |
glucose-util | yes | 89.456 | no |
thermophile | no | 96.08 | no |
glucose-ferment | no | 91.485 | no |
External links
@ref: 381
culture collection no.: DSM 738, ATCC 27064, DSM 41253, NRRL 3585, BCRC 11518, CBS 226.75, CCRC 11518, CECT 3125, CGMCC 4.1611, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, VKM Ac-602, DSM 40751, MTCC 1142, NBIMCC 3333, NCIMB 14335
straininfo link
- @ref: 84208
- straininfo: 125802
literature
topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
---|---|---|---|---|---|---|---|---|
Metabolism | 879738 | Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus. | Reading C, Cole M | Antimicrob Agents Chemother | 10.1128/AAC.11.5.852 | 1977 | Amidohydrolases/*antagonists & inhibitors, Anti-Bacterial Agents/*pharmacology, Cephalosporinase/metabolism, Chromatography, Paper, Chromatography, Thin Layer, Drug Stability, Drug Synergism, Penicillinase/metabolism, Streptomyces/*metabolism, *beta-Lactamase Inhibitors, beta-Lactams/isolation & purification/metabolism/*pharmacology | Enzymology |
Enzymology | 1366380 | Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus. | Rollins MJ, Jensen SE, Wolfe S, Westlake DW | Enzyme Microb Technol | 10.1016/0141-0229(90)90178-s | 1990 | Cephamycins/*biosynthesis, Fermentation, *Intramolecular Transferases, Isomerases/*biosynthesis, Kinetics, Oxidoreductases/biosynthesis, Oxygen/*pharmacology, *Penicillin-Binding Proteins, Penicillins/*metabolism, Streptomyces/drug effects/enzymology/*metabolism | Metabolism |
Enzymology | 1366440 | Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585. | Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain AL | Appl Microbiol Biotechnol | 10.1007/BF00173728 | 1990 | Bacterial Proteins/metabolism, Cephalosporins/*biosynthesis, Cloning, Molecular, DNA, Bacterial/genetics/isolation & purification, Gene Expression Regulation, Bacterial/genetics, Genetic Complementation Test, *Mutation, Oxidoreductases/genetics, Peptide Synthases/genetics, Phenotype, Plasmids/genetics, Restriction Mapping, Streptomyces/enzymology/*genetics/metabolism, Transformation, Bacterial | Metabolism |
Metabolism | 1556020 | Characterization of an inducible transport system for glycerol in Streptomyces clavuligerus. Repression by L-serine. | Minambres B, Reglero A, Luengo JM | J Antibiot (Tokyo) | 10.7164/antibiotics.45.269 | 1992 | Biological Transport, Active/drug effects, Culture Media/chemistry, Fatty Acids/pharmacology, Glycerol/*pharmacokinetics, Maltose/metabolism, Serine/pharmacology, Streptomyces/*metabolism, Temperature, Time Factors | Pathogenicity |
Phylogeny | 2107074 | Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes. | Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner G | EMBO J | 10.1002/j.1460-2075.1990.tb08168.x | 1990 | Anti-Bacterial Agents/*biosynthesis, Aspergillus nidulans/*genetics, Cloning, Molecular, Cosmids, DNA, Bacterial/genetics/isolation & purification, DNA, Fungal/genetics/isolation & purification, Flavobacterium/*genetics, Gene Library, *Genes, Bacterial, *Genes, Fungal, *Multigene Family, Nucleic Acid Hybridization, Penicillium/*genetics, Penicillium chrysogenum/*genetics, Peptide Synthases/genetics, Restriction Mapping, Sequence Homology, Nucleic Acid, Species Specificity, Streptomyces/*genetics, beta-Lactams | Enzymology |
Enzymology | 2129789 | Regulation of ACV synthetase: biosynthesis and action. | Zhang JY, Demain AL | Chin J Biotechnol | 1990 | Acremonium/*enzymology, Ammonia/pharmacology, Cephalosporins/biosynthesis, Gene Expression Regulation, Fungal, Glucose/pharmacology, Glucose-6-Phosphate, Glucosephosphates/pharmacology, Glyceric Acids/pharmacology, Peptide Synthases/*biosynthesis, Streptomyces/enzymology | ||
Enzymology | 2207091 | Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis. | Salowe SP, Marsh EN, Townsend CA | Biochemistry | 10.1021/bi00479a023 | 1990 | Aza Compounds/metabolism, Chromatography, Gel, Chromatography, Ion Exchange, Fungal Proteins/*isolation & purification/metabolism, Iron/metabolism, Ketoglutaric Acids/metabolism, Kinetics, Mixed Function Oxygenases/*isolation & purification/metabolism, Oxidation-Reduction, Oxygen/metabolism, Streptomyces/*enzymology | Metabolism |
Metabolism | 2599054 | Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium. | Jermini MF, Demain AL | Experientia | 10.1007/BF01950159 | 1989 | Acremonium/growth & development/*metabolism, Cephalosporins/*biosynthesis, Cephamycins/biosynthesis, Culture Media, Fermentation, Hordeum, Kinetics, Streptomyces/growth & development/*metabolism, Temperature | Cultivation |
Metabolism | 2687256 | Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant. | Garcia-Dominguez M, Martin JF, Liras P | J Bacteriol | 10.1128/jb.171.12.6808-6814.1989 | 1989 | Biological Transport, Active, Deoxyglucose/metabolism, Glucokinase/metabolism, Glucose/*metabolism, Glucosephosphate Dehydrogenase/metabolism, Kinetics, Methylnitronitrosoguanidine/pharmacology, *Mutation, Phosphorylation, Streptomyces/drug effects/genetics/*metabolism, alpha-Glucosidases/metabolism | Enzymology |
Enzymology | 6833140 | Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity. | Pruess DL, Kellett M | J Antibiot (Tokyo) | 10.7164/antibiotics.36.208 | 1983 | Anti-Bacterial Agents/*isolation & purification/pharmacology, Chemical Phenomena, Chemistry, Clavulanic Acids/*isolation & purification/pharmacology, Microbial Sensitivity Tests, Streptomyces/*metabolism | Phylogeny |
Metabolism | 7142003 | High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus. | Jensen SE, Westlake DW, Wolfe S | J Antibiot (Tokyo) | 10.7164/antibiotics.35.1026 | 1982 | Anti-Bacterial Agents/*biosynthesis, Cell-Free System, Chromatography, High Pressure Liquid, Oligopeptides/*metabolism, Penicillins/*biosynthesis, Streptomyces/analysis/*metabolism | |
Genetics | 7557307 | Giant linear plasmids of beta-lactam antibiotic producing Streptomyces. | Netolitzky DJ, Wu X, Jensen SE, Roy KL | FEMS Microbiol Lett | 10.1016/0378-1097(95)00230-3 | 1995 | Anti-Bacterial Agents/*biosynthesis, Base Sequence, Centrifugation, Density Gradient, Chromosome Mapping, DNA, Bacterial/*analysis, Extrachromosomal Inheritance/genetics, Molecular Sequence Data, Nucleic Acid Conformation, Plasmids/*genetics, *Sequence Homology, Nucleic Acid, Streptomyces/*genetics/metabolism, Sucrose, beta-Lactams | Metabolism |
Enzymology | 8431021 | Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans. | Xiao X, Hintermann G, Hausler A, Barker PJ, Foor F, Demain AL, Piret J | Antimicrob Agents Chemother | 10.1128/AAC.37.1.84 | 1993 | Amino Acid Sequence, Bacteriophages/metabolism, Blotting, Southern, Chromatography, High Pressure Liquid, Cloning, Molecular, DNA Probes, DNA, Bacterial/*biosynthesis, Gene Expression, Mixed Function Oxygenases/*biosynthesis/genetics, Molecular Sequence Data, Nucleic Acid Hybridization, Oligonucleotides, Polymerase Chain Reaction, Recombination, Genetic, Streptomyces/enzymology/*metabolism | Metabolism |
Metabolism | 8852680 | Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture. | Cochet N, Demain AL | J Appl Bacteriol | 10.1111/j.1365-2672.1996.tb03228.x | 1996 | Anti-Bacterial Agents/*biosynthesis, Biological Transport, Carbon/metabolism, Culture Media, Glucose/metabolism, Sodium Chloride/metabolism, Sorbitol/metabolism, Streptomyces/growth & development/*metabolism, *Water Microbiology, beta-Lactams | Cultivation |
Enzymology | 9846758 | Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate. | Chan M, Sim TS | Microbiology (Reading) | 10.1099/00221287-144-11-3229 | 1998 | Acetates/*metabolism, Amino Acid Sequence, Base Sequence, Cloning, Molecular, Culture Media, Escherichia coli/enzymology, Genes, Bacterial, Malate Synthase/chemistry/*genetics/*metabolism, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction/methods, Promoter Regions, Genetic/genetics, Recombinant Proteins/biosynthesis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity, Streptomyces/*enzymology/genetics/growth & development | Genetics |
Metabolism | 11540168 | Lysine epsilon-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes. | Rius N, Demain AL | J Microbiol Biotechnol | 1997 | Ammonium Chloride/pharmacology, Carbon/metabolism, Cephalosporins/*biosynthesis, *Gene Expression Regulation, Bacterial, L-Lysine 6-Transaminase, Lactams/metabolism, Lysine/metabolism/pharmacology, Nocardia/enzymology/*genetics/*metabolism, Phosphates/pharmacology, Promoter Regions, Genetic/physiology, Streptomyces/enzymology/*genetics/*metabolism, Transaminases/drug effects/genetics/isolation & purification/*metabolism, Transcription, Genetic/physiology | Enzymology | |
Enzymology | 11750062 | Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585. | Soh BS, Loke P, Sim TS | Biochim Biophys Acta | 10.1016/s0167-4781(01)00309-8 | 2001 | Bacterial Proteins, Cloning, Molecular, DNA/chemistry, Escherichia coli/genetics/metabolism, Isocitrate Lyase/biosynthesis/*genetics/isolation & purification, Molecular Sequence Data, Open Reading Frames, Operon, Phylogeny, Streptomyces/enzymology/*genetics | Phylogeny |
Metabolism | 12003953 | CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. | Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, Martin JF, Liras P | J Bacteriol | 10.1128/JB.184.11.3106-3113.2002 | 2002 | Amino Acid Isomerases/*genetics/metabolism, *Bacterial Proteins, Cephamycins/*biosynthesis, Clavulanic Acid/biosynthesis/*metabolism, DNA-Binding Proteins/*genetics/isolation & purification/metabolism, Genes, Bacterial, Genes, Regulator, Promoter Regions, Genetic, Recombinant Fusion Proteins/metabolism, Streptomyces/*genetics/metabolism, Transcription Factors/metabolism | Enzymology |
Enzymology | 15313252 | Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus. | Tunca S, Yilmaz EI, Piret J, Liras P, Ozcengiz G | Res Microbiol | 10.1016/j.resmic.2004.03.007 | 2004 | Aspartate Kinase/antagonists & inhibitors/*genetics/isolation & purification/metabolism, Aspartate-Semialdehyde Dehydrogenase/antagonists & inhibitors/*genetics/isolation & purification/metabolism, Cephamycins/*biosynthesis, Cloning, Molecular, Codon, Initiator, Codon, Terminator, Open Reading Frames/genetics, *Operon, Rifamycins/biosynthesis, Sequence Analysis, DNA, Sequence Homology, Streptomyces/enzymology/*genetics/metabolism | Metabolism |
Metabolism | 15464601 | Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064. | Jin W, Kim HK, Kim JY, Kang SG, Lee SH, Lee KJ | J Biotechnol | 10.1016/j.jbiotec.2004.06.010 | 2004 | Anti-Bacterial Agents/biosynthesis, Bacterial Proteins/genetics/*metabolism, Cell Culture Techniques/methods, Cell Proliferation, Cephamycins/*biosynthesis, Gene Expression Regulation, Bacterial/physiology, Glycerol/*metabolism, Ligases/genetics/*metabolism, Phosphates/*metabolism, Species Specificity, Streptomyces/*genetics/*physiology | Phylogeny |
Genetics | 16699579 | Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus. | Wu W, Leblanc SK, Piktel J, Jensen SE, Roy KL | Can J Microbiol | 10.1139/w05-126 | 2006 | Bacterial Proteins/genetics, Base Sequence, DNA Replication/genetics, DNA, Bacterial/biosynthesis, Molecular Sequence Data, Open Reading Frames/genetics, Plasmids/chemistry/*genetics, Polymerase Chain Reaction, Replication Origin/*genetics/physiology, Replicon/genetics, Restriction Mapping, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Streptomyces/*genetics | Transcriptome |
Metabolism | 17625238 | A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142. | Saudagar PS, Singhal RS | Appl Biochem Biotechnol | 10.1007/s12010-007-9030-x | 2007 | Amino Acids/metabolism, Anti-Bacterial Agents/*biosynthesis, Biotechnology/*methods/*statistics & numerical data, Carbon/chemistry, Clavulanic Acid/*biosynthesis/chemistry, Culture Media/chemistry, Fermentation, Hydrogen-Ion Concentration, Nitrogen/chemistry, Soybean Oil/metabolism, Streptomyces/*metabolism | Biotechnology |
Metabolism | 17877708 | Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production. | Santamarta I, Lopez-Garcia MT, Perez-Redondo R, Koekman B, Martin JF, Liras P | Mol Microbiol | 10.1111/j.1365-2958.2007.05937.x | 2007 | Acetates/metabolism, Amino Acid Sequence, Bacterial Proteins/genetics/*metabolism, Blotting, Southern, Cephamycins/*metabolism, Clavulanic Acid/*metabolism, Fatty Acids/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Leucine/*metabolism, Molecular Sequence Data, Mutation, Operon, Protein Binding, Reverse Transcriptase Polymerase Chain Reaction, Streptomyces/genetics/*metabolism, Transcription, Genetic/genetics | Genetics |
Enzymology | 17909870 | Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus. | Yilmaz EI, Caydasi AK, Ozcengiz G | J Ind Microbiol Biotechnol | 10.1007/s10295-007-0259-8 | 2007 | Anti-Bacterial Agents/*biosynthesis, Cephamycins/*biosynthesis, Cloning, Molecular, Culture Media, Escherichia coli/enzymology/genetics, Gene Expression Regulation, Bacterial, *Gene Silencing, Homoserine Dehydrogenase/*genetics/metabolism, Industrial Microbiology/methods, Recombinant Proteins/genetics/isolation & purification/metabolism, Streptomyces/*enzymology/genetics/growth & development/metabolism | Metabolism |
Metabolism | 18062234 | Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585. | Hung TV, Malla S, Park BC, Liou K, Lee HC, Sohng JK | J Microbiol Biotechnol | 2007 | Bacterial Proteins/*physiology, Clavulanic Acids/*biosynthesis, *Gene Expression Regulation, Bacterial, Genes, Regulator, Plasmids/genetics, Recombinant Proteins/genetics/metabolism, Streptomyces/genetics/*metabolism | ||
Metabolism | 18388457 | Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064. | Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ | J Microbiol Biotechnol | 7169 | 2008 | Bacterial Proteins/genetics/metabolism, Biosynthetic Pathways, Clavulanic Acid/*metabolism, Fermentation, Gene Dosage, *Gene Expression, Gene Expression Regulation, Bacterial, Genetic Vectors, Kinetics, Streptomyces/*enzymology/genetics, Transcription, Genetic, Ureohydrolases/*genetics/*metabolism | Enzymology |
Biotechnology | 19011915 | A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production. | Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ | J Ind Microbiol Biotechnol | 10.1007/s10295-008-0499-2 | 2008 | Anti-Bacterial Agents/biosynthesis, Bacterial Proteins/*genetics, Biotechnology/methods, Cephamycins/biosynthesis, Clavulanic Acid/*biosynthesis, Culture Media, *Gene Expression Regulation, Bacterial, *Multigene Family, Mutation, Open Reading Frames/genetics, Streptomyces/genetics/*metabolism | Cultivation |
Metabolism | 19129630 | An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus. | Kim SJ, Kim JO, Shin CH, Park HW, Kim CW | Biosci Biotechnol Biochem | 10.1271/bbb.80569 | 2009 | Clavulanic Acid/*biosynthesis, Fatty Acids, Nonesterified/metabolism, Fermentation, Mutation, Oleic Acid/metabolism, Streptomyces/growth & development/*metabolism, Triolein/metabolism | Biotechnology |
Genetics | 19168979 | A two-component regulatory system involved in clavulanic acid production. | Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JK | J Antibiot (Tokyo) | 10.1038/ja.2008.92 | 2008 | Amino Acid Sequence, Bacterial Proteins/genetics/physiology, Clavulanic Acid/*biosynthesis, DNA, Bacterial/chemistry/genetics, Gene Deletion, Gene Dosage, *Gene Expression Regulation, Bacterial, Gene Order, Genes, Bacterial, Genetic Complementation Test, Molecular Sequence Data, Multigene Family, Sequence Alignment, Sequence Analysis, DNA, Streptomyces/genetics/metabolism/*physiology, Trans-Activators/genetics/*physiology | Transcriptome |
Metabolism | 19286797 | Glycerol utilization gene cluster in Streptomyces clavuligerus. | Banos S, Perez-Redondo R, Koekman B, Liras P | Appl Environ Microbiol | 10.1128/AEM.00181-09 | 2009 | Base Sequence, Clavulanic Acid/biosynthesis, DNA, Bacterial/chemistry/genetics, Gene Deletion, Gene Dosage, Gene Expression Profiling, Gene Order, Genes, Bacterial, Glucose/metabolism, Glycerol/*metabolism, Metabolic Networks and Pathways/*genetics, Molecular Sequence Data, *Multigene Family, Sequence Analysis, DNA, Streptomyces/*genetics/growth & development | Genetics |
Metabolism | 19374992 | Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete. | Liras P, Demain AL | Methods Enzymol | 10.1016/S0076-6879(09)04816-2 | 2009 | Actinobacteria/*enzymology/genetics/*metabolism, Cephamycins/chemistry/metabolism, Intramolecular Transferases/genetics/metabolism, Molecular Structure, Oxidoreductases/genetics/metabolism, Oxygenases/genetics/metabolism, Penicillin-Binding Proteins/genetics/metabolism, beta-Lactams/chemistry/*metabolism | Enzymology |
Metabolism | 20110297 | The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene. | Perez-Redondo R, Santamarta I, Bovenberg R, Martin JF, Liras P | Microbiology (Reading) | 10.1099/mic.0.035840-0 | 2010 | Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Base Sequence, DNA, Bacterial, Escherichia coli/genetics, Genes, Bacterial, Genetic Complementation Test, Glucokinase/genetics/metabolism, Glucose/*metabolism, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/*genetics/metabolism, Promoter Regions, Genetic, Recombination, Genetic, Streptomyces/enzymology/genetics/*metabolism, Streptomyces coelicolor/genetics | Genetics |
Metabolism | 20112672 | [Evaluation of the activities of two promoters in Streptomycetes by reporter gene method]. | Li J, Xiang S, Yang X, Yang K | Wei Sheng Wu Xue Bao | 2009 | Bacterial Proteins/genetics/metabolism, Base Sequence, Drug Resistance, Bacterial, Gene Expression Regulation, Bacterial, *Genes, Reporter, Molecular Sequence Data, *Promoter Regions, Genetic, Streptomyces/*genetics/metabolism | Genetics | |
Metabolism | 20134246 | Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585. | Jnawali HN, Lee HC, Sohng JK | J Microbiol Biotechnol | JMB020-01-20 | 2010 | Bacterial Proteins/*genetics/metabolism, Clavulanic Acid/*biosynthesis, *Gene Deletion, *Gene Expression Regulation, Bacterial, Genes, Regulator, Glyceraldehyde-3-Phosphate Dehydrogenases/*genetics/metabolism, Glycerol/metabolism, Sequence Deletion, Streptomyces/enzymology/genetics/*metabolism | Enzymology |
Genetics | 20624727 | The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways. | Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Muller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano E | Genome Biol Evol | 10.1093/gbe/evq013 | 2010 | Bacterial Proteins/genetics/metabolism, Chromosomes, Bacterial/genetics, DNA, Bacterial/*genetics, *Evolution, Molecular, Genome, Bacterial, Metabolic Networks and Pathways/*genetics, Models, Biological, Models, Genetic, Molecular Sequence Data, Multigene Family, Phylogeny, Plasmids/*genetics, Replicon, Streptomyces/*genetics/*metabolism | Metabolism |
Metabolism | 20870400 | Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585. | Jnawali HN, Liou K, Sohng JK | Microbiol Res | 10.1016/j.micres.2010.07.005 | 2010 | Clavulanic Acid/*biosynthesis, Culture Media/chemistry, Gene Expression Profiling, Gene Knockout Techniques, Mutagenesis, Insertional, Reverse Transcriptase Polymerase Chain Reaction, Sigma Factor/genetics/*metabolism, Spores, Bacterial/growth & development, Streptomyces/cytology/genetics/*growth & development/*metabolism | Biotechnology |
Enzymology | 20888207 | Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production. | Kanth BK, Jnawali HN, Niraula NP, Sohng JK | Microbiol Res | 10.1016/j.micres.2010.07.003 | 2010 | Anti-Bacterial Agents/biosynthesis, Biomass, Cloning, Molecular, DNA, Bacterial/chemistry/genetics, Gene Expression, Gene Expression Profiling, *Metabolome, Molecular Sequence Data, Sequence Analysis, DNA, Streptomyces/*enzymology/genetics/*metabolism, Superoxide Dismutase/*genetics/*metabolism | Genetics |
Genetics | 20889745 | Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites. | Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JF | J Bacteriol | 10.1128/JB.00859-10 | 2010 | Biosynthetic Pathways/genetics, Chromosomes, Bacterial, DNA, Bacterial/*chemistry/*genetics, *Genome, Bacterial, Molecular Sequence Data, Plasmids, Sequence Analysis, DNA/methods, Streptomyces/*genetics | Transcriptome |
Metabolism | 21041678 | Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus. | Li B, Walsh CT | Proc Natl Acad Sci U S A | 10.1073/pnas.1014140107 | 2010 | Acyltransferases/genetics/metabolism, Anti-Bacterial Agents/*biosynthesis/chemistry, Bacterial Proteins/genetics/metabolism, Computational Biology, Cysteine/metabolism, Enzyme Assays, Gene Deletion, Genes, Bacterial/*genetics, Lactams/chemistry/*metabolism, Multigene Family/*genetics, Open Reading Frames/genetics, Pyrroles/chemistry/*metabolism, Spectrometry, Mass, Electrospray Ionization, Streptomyces/enzymology/*genetics | Enzymology |
Enzymology | 21153459 | Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis. | Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng Z | Protein Cell | 10.1007/s13238-010-0127-6 | 2010 | Actinobacteria/*enzymology/genetics, Base Sequence, Biological Assay, Carbohydrate Sequence, Carbohydrates/*biosynthesis/genetics, Cloning, Molecular, Gene Deletion, Gene Library, High-Throughput Screening Assays, Molecular Sequence Data, Multigene Family, Recombinant Proteins/*biosynthesis/genetics, Sequence Analysis, DNA, Streptomyces/*enzymology/*genetics, Tunicamycin/*biosynthesis/chemistry/genetics | Genetics |
Metabolism | 21326925 | Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production. | Ozcengiz G, Okay S, Unsaldi E, Taskin B, Liras P, Piret J | Bioeng Bugs | 10.4161/bbug.1.3.11244 | 2010 | Aspartate Kinase/*genetics/metabolism, Bacterial Proteins/*genetics/metabolism, Bioengineering, Cephamycins/*biosynthesis, Culture Media/metabolism, Gene Dosage, *Gene Expression, Homoserine Dehydrogenase/*genetics/metabolism, *Sequence Deletion, Streptomyces/*enzymology/genetics/metabolism | Enzymology |
Metabolism | 21342467 | A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production. | Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras P | Microb Biotechnol | 10.1111/j.1751-7915.2010.00222.x | 2010 | Bacterial Proteins/genetics/*metabolism, Cephamycins/biosynthesis, Clavulanic Acid/metabolism, Gene Expression Regulation, Bacterial, Lactams/*metabolism, Membrane Transport Proteins/genetics/*metabolism, *Mutation, Streptomyces/enzymology/genetics/*metabolism, Thiosulfate Sulfurtransferase/genetics/*metabolism | Biotechnology |
Metabolism | 21696462 | Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus. | Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, Martin JF, Liras P | Mol Microbiol | 10.1111/j.1365-2958.2011.07743.x | 2011 | Binding Sites, Biosynthetic Pathways/genetics, Cephamycins/biosynthesis, Clavulanic Acid/biosynthesis, DNA Footprinting, DNA, Bacterial/*genetics/*metabolism, Electrophoresis, Gel, Two-Dimensional, Electrophoretic Mobility Shift Assay, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Gene Knockout Techniques, *Multigene Family, Mutagenesis, Insertional, RNA, Messenger/biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Streptomyces/*genetics/*metabolism, Trans-Activators/*metabolism | Enzymology |
Metabolism | 23109012 | Prediction of the pho regulon in Streptomyces clavuligerus DSM 738. | Salehghamari E, Hamedi J, Elahi E, Sepehrizadeh Z, Sadeghi M, Muth G | New Microbiol | 2012 | Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, Binding Sites, Consensus Sequence, *Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phosphates/metabolism, Promoter Regions, Genetic, Protein Binding, *Regulon, Streptomyces/chemistry/*genetics/metabolism | Genetics | |
Metabolism | 23147422 | Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus. | Robles-Reglero V, Santamarta I, Alvarez-Alvarez R, Martin JF, Liras P | J Biotechnol | 10.1016/j.jbiotec.2012.09.017 | 2012 | Bacterial Proteins/genetics/metabolism, Gene Expression Profiling/*methods, Lactams/*metabolism, *Multigene Family, Mutation, Proteomics/methods, Streptomyces/*genetics/*metabolism, Transcriptome | Transcriptome |
Phylogeny | 23508694 | Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus , PTCC 1709. | Hojati Z, Salehi Z, Motovali-Bashi M, Korbekandi H, Jami S | Cell J | 2011 | |||
Metabolism | 23832248 | Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus. | Guo D, Zhao Y, Yang K | Sci China Life Sci | 10.1007/s11427-013-4507-z | 2013 | Base Sequence, Chemistry, Pharmaceutical/methods, Clavulanic Acid/*biosynthesis, Escherichia coli/metabolism, Gene Expression Regulation, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Glyceraldehyde 3-Phosphate/chemistry, Glycerol/chemistry/*metabolism, Multigene Family, Oligonucleotides/genetics, Operon, Plasmids/metabolism, Promoter Regions, Genetic, Streptomyces/*metabolism, Time Factors | Biotechnology |
Metabolism | 24323287 | Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus. | Liras P | Appl Microbiol Biotechnol | 10.1007/s00253-013-5410-z | 2013 | Antibiotics, Antineoplastic/*metabolism, Biosynthetic Pathways/*genetics, Lactams/*metabolism, *Multigene Family, Streptomyces/*genetics/*metabolism | |
Biotechnology | 24363725 | Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus. | Korbekandi H, Darkhal P, Hojati Z, Abedi D, Hamedi J, Pourhosein M | Iran J Pharm Res | 2010 | |||
Metabolism | 24450885 | Transcriptomic analysis of Streptomyces clavuligerus DeltaccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation. | Alvarez-Alvarez R, Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Prieto-Dominguez A, Martinez-Burgo Y, Liras P | Microb Biotechnol | 10.1111/1751-7915.12109 | 2014 | Biosynthetic Pathways/*genetics, Cephamycins/*metabolism, Clavulanic Acid/*metabolism, Culture Media/chemistry, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Genes, Reporter, Luciferases/analysis/genetics, *Multigene Family, Real-Time Polymerase Chain Reaction, Streptomyces/genetics/growth & development/*metabolism, Transcription Factors/*genetics | Cultivation |
Metabolism | 24688492 | Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064. | da Silva Vasconcelos E, de Lima VA, Goto LS, Cruz-Hernandez IL, Hokka CO | Braz J Microbiol | 10.1590/S1517-83822014005000005 | 2014 | Clavulanic Acid/*metabolism, Culture Media/chemistry, Lipase/metabolism, *Metabolic Engineering, Methyl Methanesulfonate, *Mutagenesis, *Mutation, Streptomyces/drug effects/genetics/*metabolism/radiation effects, Ultraviolet Rays | Biotechnology |
Metabolism | 24975573 | Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster. | Martinez-Burgo Y, Alvarez-Alvarez R, Perez-Redondo R, Liras P | J Biotechnol | 10.1016/j.jbiotec.2014.06.002 | 2014 | Anti-Bacterial Agents/*metabolism/pharmacology, Bacteria/drug effects, Cephamycins/*metabolism/pharmacology, Cloning, Molecular, DNA, Recombinant, Gene Transfer Techniques, Microbial Sensitivity Tests, Multigene Family/*genetics, Streptomyces/*genetics/*metabolism | Enzymology |
Metabolism | 25477926 | Screening of wild type Streptomyces isolates able to overproduce clavulanic acid. | Viana Marques DA, Santos-Ebinuma Vde C, de Oliveira PM, Lima GM, Araujo JM, Lima-Filho JL, Converti A, Pessoa-Junior A, Porto AL | Braz J Microbiol | 10.1590/s1517-83822014000300022 | 2014 | Clavulanic Acid/*metabolism, Enterobacter aerogenes/enzymology, Enzyme Inhibitors/*metabolism, Mass Screening, Streptomyces/growth & development/*isolation & purification/*metabolism, beta-Lactamases/metabolism | Enzymology |
Metabolism | 26187955 | The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation. | Martinez-Burgo Y, Alvarez-Alvarez R, Rodriguez-Garcia A, Liras P | Appl Environ Microbiol | 10.1128/AEM.00916-15 | 2015 | Bacterial Proteins/genetics/*metabolism, Clavulanic Acid/metabolism, *Gene Expression Regulation, Bacterial, *Secondary Metabolism, Sigma Factor/genetics/metabolism, Streptomyces/genetics/*growth & development/*metabolism, Transcription Factors/genetics/*metabolism, Transcription, Genetic | |
26469060 | A method for investigating the stereochemical course of terpene cyclisations. | Rabe P, Rinkel J, Klapschinski TA, Barra L, Dickschat JS | Org Biomol Chem | 10.1039/c5ob01998b | 2016 | Cyclization, Molecular Conformation, Stereoisomerism, Terpenes/*chemistry | ||
Genetics | 26527303 | Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor. | Li S, Wang W, Li X, Fan K, Yang K | Sci Rep | 10.1038/srep15840 | 2015 | Cluster Analysis, Gene Expression Profiling/*methods/standards, *Gene Expression Regulation, Bacterial, Genes, Bacterial/*genetics, Genome, Bacterial/*genetics, Oligonucleotide Array Sequence Analysis/methods/standards, Reference Standards, Reverse Transcriptase Polymerase Chain Reaction/methods/standards, Streptomyces coelicolor/*genetics | Transcriptome |
Metabolism | 26814669 | Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms. | Yamada Y, Komatsu M, Ikeda H | J Antibiot (Tokyo) | 10.1038/ja.2015.147 | 2016 | Actinomycetales/*enzymology/genetics, Bacterial Proteins/chemistry/genetics/metabolism, Cell Engineering, Cyclization, Databases, Chemical, Diterpenes/chemistry/*metabolism, Streptomyces/genetics | Enzymology |
Metabolism | 30194098 | Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis. | Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Martin JF, Liras P | Appl Environ Microbiol | 10.1128/AEM.01701-18 | 2018 | Bacterial Proteins/*genetics/metabolism, Clavulanic Acid/*biosynthesis/chemistry, Clavulanic Acids/metabolism, Gene Expression Regulation, Bacterial, Membrane Transport Proteins/*genetics/metabolism, Multigene Family, Operon, *Sequence Deletion, Streptomyces/*enzymology/genetics/*metabolism, *Transcription, Genetic | Enzymology |
30456006 | Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1. | Li J, Zhao Z, Zhong W, Zhong C, Zong G, Fu J, Cao G | 3 Biotech | 10.1007/s13205-018-1498-2 | 2018 | |||
Metabolism | 30837970 | The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1. | Fu J, Qin R, Zong G, Liu C, Kang N, Zhong C, Cao G | Front Microbiol | 10.3389/fmicb.2019.00244 | 2019 | ||
30891203 | A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications. | Ayala-Ruano S, Santander-Gordon D, Tejera E, Perez-Castillo Y, Armijos-Jaramillo V | Ecol Evol | 10.1002/ece3.4924 | 2019 | |||
30984130 | Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis. | Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras P | Front Microbiol | 10.3389/fmicb.2019.00580 | 2019 | |||
Transcriptome | 31330947 | Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions. | Pinilla L, Toro LF, Laing E, Alzate JF, Rios-Estepa R | Antibiotics (Basel) | 10.3390/antibiotics8030096 | 2019 | ||
31352530 | The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1. | Fu J, Qin R, Zong G, Zhong C, Zhang P, Kang N, Qi X, Cao G | AMB Express | 10.1186/s13568-019-0844-z | 2019 | |||
Metabolism | 32707026 | Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus. | Unsaldi E, Kurt-Kizildogan A, Ozcan S, Becher D, Voigt B, Aktas C, Ozcengiz G | Protein Pept Lett | 10.2174/0929866527666200723163655 | 2021 | Anti-Bacterial Agents/metabolism, Bacterial Proteins/*metabolism, Cephamycins/*metabolism, Gene Expression Regulation, Bacterial, Homoserine Dehydrogenase/*deficiency/genetics, Proteome/*analysis/*metabolism, Streptomyces/genetics/growth & development/*metabolism, Tandem Mass Spectrometry/*methods | Proteome |
33947798 | Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome. | Hwang S, Lee N, Choe D, Lee Y, Kim W, Jeong Y, Cho S, Palsson BO, Cho BK | mSystems | 10.1128/mSystems.01013-20 | 2021 | |||
34747689 | Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus. | Gomez-Escribano JP, Algora Gallardo L, Bozhuyuk KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson B | Microb Genom | 10.1099/mgen.0.000669 | 2021 | Chromosomes, *Gene Editing/methods, Plasmids/genetics, *Streptomyces/genetics | ||
Genetics | 35138454 | Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064. | Pivk Lukancic P, Drcar T, Bruccoleri R, Crnugelj M, Mrak P | Appl Microbiol Biotechnol | 10.1007/s00253-022-11805-5 | 2022 | Clavulanic Acid, Genotype, *Lyngbya Toxins/metabolism, *Streptomyces/genetics/metabolism | Metabolism |
Biotechnology | 35200432 | Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064. | Patino LF, Aguirre-Hoyos V, Pinilla LI, Toro LF, Rios-Estepa R | Bioengineering (Basel) | 10.3390/bioengineering9020078 | 2022 | ||
Proteome | 35945361 | An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus. | Kurt-Kizildogan A, Celik G, Unsaldi E, Ozcan S, Ayaz-Guner S, Ozcengiz G | Appl Microbiol Biotechnol | 10.1007/s00253-022-12098-4 | 2022 | Clavulanic Acid, *Gene Expression Regulation, Bacterial, *Proteome/metabolism, Streptomyces, Tandem Mass Spectrometry | Metabolism |
Metabolism | 36504789 | Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585. | Zhang C, Zhao Y, Li Z, Wang W, Huang Y, Pan G, Fan K | Front Microbiol | 10.3389/fmicb.2022.1078293 | 2022 |
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20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |||
20216 | Curators of the HKI | http://www.leibniz-hki.de/de/ | Collection Description Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) | |||
20218 | Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P. | 10.1016/j.syapm.2013.11.002 | StrainInfo introduces electronic passports for microorganisms. | Syst Appl Microbiol. 37: 42-50 2014 | 24321274 | |
66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
66794 | Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg | 10.1093/nar/gkaa1025 | BRENDA, the ELIXIR core data resource in 2021: new developments and updates | Nucleic Acids Res. 49: D498-D508 2020 | 33211880 | |
67770 | Curators of the JCM | https://jcm.brc.riken.jp/en/ | ||||
69480 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |||
69481 | Xiao-Yin To, René Mreches, Martin Binder, Alice C. McHardy, Philipp C. Münch | 10.21203/rs.3.rs-2527258/v1 | Predictions based on the model GenomeNet Sporulation v. 1 | |||
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