Strain identifier

BacDive ID: 15101

Type strain: Yes

Species: Streptomyces clavuligerus

Strain history: KCC S-0710 <-- Tanabe Seiyaku Co., Ltd., Japan; MCRL 0774 <-- NRRL 3585 <-- Eli Lilly & Co., USA.

NCBI tax ID(s): 1901 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.
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General

@ref: 381

BacDive-ID: 15101

DSM-Number: 738

keywords: genome sequence, 16S sequence, Bacteria, spore-forming, mesophilic

description: Streptomyces clavuligerus DSM 738 is a spore-forming, mesophilic bacterium that was isolated from soil.

NCBI tax id

  • NCBI tax id: 1901
  • Matching level: species

strain history

@refhistory
381<- ATCC <- C.E. Higgens
67770KCC S-0710 <-- Tanabe Seiyaku Co., Ltd., Japan; MCRL 0774 <-- NRRL 3585 <-- Eli Lilly & Co., USA.

doi: 10.13145/bacdive15101.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/actinomycetota
  • domain: Bacteria
  • phylum: Actinomycetota
  • class: Actinomycetes
  • order: Kitasatosporales
  • family: Streptomycetaceae
  • genus: Streptomyces
  • species: Streptomyces clavuligerus
  • full scientific name: Streptomyces clavuligerus Higgens and Kastner 1971 (Approved Lists 1980)

@ref: 381

domain: Bacteria

phylum: Actinobacteria

class: Actinobacteria

order: Actinomycetales

family: Streptomycetaceae

genus: Streptomyces

species: Streptomyces clavuligerus

full scientific name: Streptomyces clavuligerus Higgens and Kastner 1971 emend. Nouioui et al. 2018

type strain: yes

Morphology

cell morphology

@refmotilityconfidencegram stain
69480no93.965
69480100positive

multimedia

@refmultimedia contentintellectual property rightscaption
381https://www.dsmz.de/microorganisms/photos/DSM_738-1.jpg© Leibniz-Institut DSMZ
381https://www.dsmz.de/microorganisms/photos/DSM_738.jpg© Leibniz-Institut DSMZMedium 65 28°C

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
381GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)yeshttps://mediadive.dsmz.de/medium/65Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
381BENNETT'S AGAR (DSMZ Medium 548)yeshttps://mediadive.dsmz.de/medium/548Name: BENNETT'S AGAR (DSMZ Medium 548) Composition: Agar 15.0 g/l Glucose 10.0 g/l N-Z amine 2.0 g/l Yeast extract 1.0 g/l Beef extract 1.0 g/l Distilled water
381NUTRIENT AGAR (DSMZ Medium 1)yeshttps://mediadive.dsmz.de/medium/1Name: NUTRIENT AGAR (DSMZ Medium 1) Composition: Agar 15.0 g/l Peptone 5.0 g/l Meat extract 3.0 g/l Distilled water

culture temp

@refgrowthtypetemperaturerange
381positivegrowth28mesophilic
67770positivegrowth28mesophilic

Physiology and metabolism

spore formation

@refspore formationconfidence
69481yes100
69480yes100

compound production

@refcompound
381peniclllin N
381benzylpenicillin
381clavulanic acid
20216Clavulansäure
20216Cephalosporine
20216Penizilline

observation

  • @ref: 67770
  • observation: quinones: MK-9(H8), MK-9(H6)

metabolite production

@refChebi-IDmetaboliteproduction
6777023066cephalosporinyes
67770487869clavulanateyes
6777018203penicillin Nyes

Isolation, sampling and environmental information

isolation

@refsample typecountry
381soil
67770SoilSouth America

isolation source categories

  • Cat1: #Environmental
  • Cat2: #Terrestrial
  • Cat3: #Soil

Safety information

risk assessment

  • @ref: 381
  • biosafety level: 1
  • biosafety level comment: Risk group (German classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Streptomyces clavuligerus gene for 16S rRNA, partial sequenceAB122716564ena443255
20218Streptomyces clavuligerus gene for 16S rRNAAB0458691486ena443255
20218Streptomyces clavuligerus gene for 16S rRNA, partial sequence, strain: NBRC 13307AB1843431462ena443255
20218Streptomyces clavuligerus 16S ribosomal RNA gene, partial sequenceAF417600356ena443255
20218Streptomyces clavuligerus ATCC 27064 strain NRRL 3585 16S ribosomal RNA gene, partial sequenceAY9997181448ena443255

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Streptomyces clavuligerus ATCC 27064GCA_005519465completencbi1901
66792Streptomyces clavuligerus ATCC 27064GCA_015708605completencbi1901
66792Streptomyces clavuligerus ATCC 27064GCA_000148465chromosomencbi1901
66792Streptomyces clavuligerus ATCC 27064GCA_000163875chromosomencbi1901
66792Streptomyces clavuligerus ATCC 27064GCA_015912395contigncbi1901
66792Streptomyces clavuligerus DSM 738GCA_015912875contigncbi1901
66792Streptomyces clavuligerus ATCC 27064GCA_015912925contigncbi1901
66792Streptomyces clavuligerus NCIMB 12785GCA_015912945contigncbi1901
66792Streptomyces clavuligerus NCIMB 14335GCA_015912435contigncbi1901
66792Streptomyces clavuligerus NRRL 3585GCA_015912895contigncbi1901
66792Streptomyces clavuligerus ATCC 27064443255.58plasmidpatric1901
66792Streptomyces clavuligerus ATCC 27064443255.59plasmidpatric1901
66792Streptomyces clavuligerus ATCC 27064443255.56plasmidpatric1901
66792Streptomyces clavuligerus ATCC 27064443255.55plasmidpatric1901
66792Streptomyces clavuligerus ATCC 27064443255.68completepatric1901
66792Streptomyces clavuligerus ATCC 27064443255.6wgspatric1901
66792Streptomyces clavuligerus ATCC 27064443255.57plasmidpatric1901
66792Streptomyces clavuligerus ATCC 27064 (Prj:47867)443255.8wgspatric1901
66792Streptomyces clavuligerus ATCC 27064 (Prj:64411)443255.19wgspatric1901
66792Streptomyces clavuligerus ATCC 27064 strain NRRL 3585443255.60plasmidpatric1901
66792Streptomyces clavuligerus strain ATCC 270641901.22completepatric1901
66792Streptomyces clavuligerus strain ATCC 270641901.34wgspatric1901
66792Streptomyces clavuligerus strain ATCC 270641901.41wgspatric1901
66792Streptomyces clavuligerus strain DSM 7381901.38wgspatric1901
66792Streptomyces clavuligerus strain NCIMB 127851901.40wgspatric1901
66792Streptomyces clavuligerus strain NCIMB 143351901.35wgspatric1901
66792Streptomyces clavuligerus strain NRRL 35851901.39wgspatric1901
66792Streptomyces clavuligerus ATCC 270642582581449draftimg1901
66792Streptomyces clavuligerus ATCC 270642502894011draftimg1901
66792Streptomyces clavuligerus ATCC 270642875420249completeimg1901
66792Streptomyces clavuligerus ATCC 27064651324105draftimg1901
66792Streptomyces clavuligerus ATCC 27064647533233draftimg1901
67770Streptomyces clavuligerus ATCC 27064GCA_000154925scaffoldncbi1901
66792Streptomyces clavuligerus DSM 738GCA_028752555completencbi1901

GC content

  • @ref: 67770
  • GC-content: 72.5
  • method: genome sequence analysis

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingyes100no
motileno93.286no
flagellatedno97.589no
gram-positiveyes87.12no
anaerobicno98.831no
aerobicyes92.124no
halophileno94.157no
spore-formingyes92.716no
glucose-utilyes89.456no
thermophileno96.08no
glucose-fermentno91.485no

External links

@ref: 381

culture collection no.: DSM 738, ATCC 27064, DSM 41253, NRRL 3585, BCRC 11518, CBS 226.75, CCRC 11518, CECT 3125, CGMCC 4.1611, IFO 13307, IMET 43657, JCM 4710, KCTC 9095, NBRC 13307, NCIMB 12785, VKM Ac-602, DSM 40751, MTCC 1142, NBIMCC 3333, NCIMB 14335

straininfo link

  • @ref: 84208
  • straininfo: 125802

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Metabolism879738Clavulanic acid: a beta-lactamase-inhiting beta-lactam from Streptomyces clavuligerus.Reading C, Cole MAntimicrob Agents Chemother10.1128/AAC.11.5.8521977Amidohydrolases/*antagonists & inhibitors, Anti-Bacterial Agents/*pharmacology, Cephalosporinase/metabolism, Chromatography, Paper, Chromatography, Thin Layer, Drug Stability, Drug Synergism, Penicillinase/metabolism, Streptomyces/*metabolism, *beta-Lactamase Inhibitors, beta-Lactams/isolation & purification/metabolism/*pharmacologyEnzymology
Enzymology1366380Oxygen derepresses deacetoxycephalosporin C synthase and increases the conversion of penicillin N to cephamycin C in Streptomyces clavuligerus.Rollins MJ, Jensen SE, Wolfe S, Westlake DWEnzyme Microb Technol10.1016/0141-0229(90)90178-s1990Cephamycins/*biosynthesis, Fermentation, *Intramolecular Transferases, Isomerases/*biosynthesis, Kinetics, Oxidoreductases/biosynthesis, Oxygen/*pharmacology, *Penicillin-Binding Proteins, Penicillins/*metabolism, Streptomyces/drug effects/enzymology/*metabolismMetabolism
Enzymology1366440Characterization and complementation of a cephalosporin-deficient mutant of Streptomyces clavuligerus NRRL 3585.Piret J, Resendiz B, Mahro B, Zhang JY, Serpe E, Romero J, Connors N, Demain ALAppl Microbiol Biotechnol10.1007/BF001737281990Bacterial Proteins/metabolism, Cephalosporins/*biosynthesis, Cloning, Molecular, DNA, Bacterial/genetics/isolation & purification, Gene Expression Regulation, Bacterial/genetics, Genetic Complementation Test, *Mutation, Oxidoreductases/genetics, Peptide Synthases/genetics, Phenotype, Plasmids/genetics, Restriction Mapping, Streptomyces/enzymology/*genetics/metabolism, Transformation, BacterialMetabolism
Metabolism1556020Characterization of an inducible transport system for glycerol in Streptomyces clavuligerus. Repression by L-serine.Minambres B, Reglero A, Luengo JMJ Antibiot (Tokyo)10.7164/antibiotics.45.2691992Biological Transport, Active/drug effects, Culture Media/chemistry, Fatty Acids/pharmacology, Glycerol/*pharmacokinetics, Maltose/metabolism, Serine/pharmacology, Streptomyces/*metabolism, Temperature, Time FactorsPathogenicity
Phylogeny2107074Beta-lactam antibiotic biosynthetic genes have been conserved in clusters in prokaryotes and eukaryotes.Smith DJ, Burnham MK, Bull JH, Hodgson JE, Ward JM, Browne P, Brown J, Barton B, Earl AJ, Turner GEMBO J10.1002/j.1460-2075.1990.tb08168.x1990Anti-Bacterial Agents/*biosynthesis, Aspergillus nidulans/*genetics, Cloning, Molecular, Cosmids, DNA, Bacterial/genetics/isolation & purification, DNA, Fungal/genetics/isolation & purification, Flavobacterium/*genetics, Gene Library, *Genes, Bacterial, *Genes, Fungal, *Multigene Family, Nucleic Acid Hybridization, Penicillium/*genetics, Penicillium chrysogenum/*genetics, Peptide Synthases/genetics, Restriction Mapping, Sequence Homology, Nucleic Acid, Species Specificity, Streptomyces/*genetics, beta-LactamsEnzymology
Enzymology2129789Regulation of ACV synthetase: biosynthesis and action.Zhang JY, Demain ALChin J Biotechnol1990Acremonium/*enzymology, Ammonia/pharmacology, Cephalosporins/biosynthesis, Gene Expression Regulation, Fungal, Glucose/pharmacology, Glucose-6-Phosphate, Glucosephosphates/pharmacology, Glyceric Acids/pharmacology, Peptide Synthases/*biosynthesis, Streptomyces/enzymology
Enzymology2207091Purification and characterization of clavaminate synthase from Streptomyces clavuligerus: an unusual oxidative enzyme in natural product biosynthesis.Salowe SP, Marsh EN, Townsend CABiochemistry10.1021/bi00479a0231990Aza Compounds/metabolism, Chromatography, Gel, Chromatography, Ion Exchange, Fungal Proteins/*isolation & purification/metabolism, Iron/metabolism, Ketoglutaric Acids/metabolism, Kinetics, Mixed Function Oxygenases/*isolation & purification/metabolism, Oxidation-Reduction, Oxygen/metabolism, Streptomyces/*enzymologyMetabolism
Metabolism2599054Solid state fermentation for cephalosporin production by Streptomyces clavuligerus and Cephalosporium acremonium.Jermini MF, Demain ALExperientia10.1007/BF019501591989Acremonium/growth & development/*metabolism, Cephalosporins/*biosynthesis, Cephamycins/biosynthesis, Culture Media, Fermentation, Hordeum, Kinetics, Streptomyces/growth & development/*metabolism, TemperatureCultivation
Metabolism2687256Characterization of sugar uptake in wild-type Streptomyces clavuligerus, which is impaired in glucose uptake, and in a glucose-utilizing mutant.Garcia-Dominguez M, Martin JF, Liras PJ Bacteriol10.1128/jb.171.12.6808-6814.19891989Biological Transport, Active, Deoxyglucose/metabolism, Glucokinase/metabolism, Glucose/*metabolism, Glucosephosphate Dehydrogenase/metabolism, Kinetics, Methylnitronitrosoguanidine/pharmacology, *Mutation, Phosphorylation, Streptomyces/drug effects/genetics/*metabolism, alpha-Glucosidases/metabolismEnzymology
Enzymology6833140Ro 22-5417, a new clavam antibiotic from Streptomyces clavuligerus. I. Discovery and biological activity.Pruess DL, Kellett MJ Antibiot (Tokyo)10.7164/antibiotics.36.2081983Anti-Bacterial Agents/*isolation & purification/pharmacology, Chemical Phenomena, Chemistry, Clavulanic Acids/*isolation & purification/pharmacology, Microbial Sensitivity Tests, Streptomyces/*metabolismPhylogeny
Metabolism7142003High performance liquid chromatographic assay of cyclization activity in cell-free systems from Streptomyces clavuligerus.Jensen SE, Westlake DW, Wolfe SJ Antibiot (Tokyo)10.7164/antibiotics.35.10261982Anti-Bacterial Agents/*biosynthesis, Cell-Free System, Chromatography, High Pressure Liquid, Oligopeptides/*metabolism, Penicillins/*biosynthesis, Streptomyces/analysis/*metabolism
Genetics7557307Giant linear plasmids of beta-lactam antibiotic producing Streptomyces.Netolitzky DJ, Wu X, Jensen SE, Roy KLFEMS Microbiol Lett10.1016/0378-1097(95)00230-31995Anti-Bacterial Agents/*biosynthesis, Base Sequence, Centrifugation, Density Gradient, Chromosome Mapping, DNA, Bacterial/*analysis, Extrachromosomal Inheritance/genetics, Molecular Sequence Data, Nucleic Acid Conformation, Plasmids/*genetics, *Sequence Homology, Nucleic Acid, Streptomyces/*genetics/metabolism, Sucrose, beta-LactamsMetabolism
Enzymology8431021Cloning of a Streptomyces clavuligerus DNA fragment encoding the cephalosporin 7 alpha-hydroxylase and its expression in Streptomyces lividans.Xiao X, Hintermann G, Hausler A, Barker PJ, Foor F, Demain AL, Piret JAntimicrob Agents Chemother10.1128/AAC.37.1.841993Amino Acid Sequence, Bacteriophages/metabolism, Blotting, Southern, Chromatography, High Pressure Liquid, Cloning, Molecular, DNA Probes, DNA, Bacterial/*biosynthesis, Gene Expression, Mixed Function Oxygenases/*biosynthesis/genetics, Molecular Sequence Data, Nucleic Acid Hybridization, Oligonucleotides, Polymerase Chain Reaction, Recombination, Genetic, Streptomyces/enzymology/*metabolismMetabolism
Metabolism8852680Effect of water activity on production of beta-lactam antibiotics by Streptomyces clavuligerus in submerged culture.Cochet N, Demain ALJ Appl Bacteriol10.1111/j.1365-2672.1996.tb03228.x1996Anti-Bacterial Agents/*biosynthesis, Biological Transport, Carbon/metabolism, Culture Media, Glucose/metabolism, Sodium Chloride/metabolism, Sorbitol/metabolism, Streptomyces/growth & development/*metabolism, *Water Microbiology, beta-LactamsCultivation
Enzymology9846758Malate synthase from Streptomyces clavuligerus NRRL3585: cloning, molecular characterization and its control by acetate.Chan M, Sim TSMicrobiology (Reading)10.1099/00221287-144-11-32291998Acetates/*metabolism, Amino Acid Sequence, Base Sequence, Cloning, Molecular, Culture Media, Escherichia coli/enzymology, Genes, Bacterial, Malate Synthase/chemistry/*genetics/*metabolism, Molecular Sequence Data, Phylogeny, Polymerase Chain Reaction/methods, Promoter Regions, Genetic/genetics, Recombinant Proteins/biosynthesis, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Species Specificity, Streptomyces/*enzymology/genetics/growth & developmentGenetics
Metabolism11540168Lysine epsilon-aminotransferase, the initial enzyme of cephalosporin biosynthesis in actinomycetes.Rius N, Demain ALJ Microbiol Biotechnol1997Ammonium Chloride/pharmacology, Carbon/metabolism, Cephalosporins/*biosynthesis, *Gene Expression Regulation, Bacterial, L-Lysine 6-Transaminase, Lactams/metabolism, Lysine/metabolism/pharmacology, Nocardia/enzymology/*genetics/*metabolism, Phosphates/pharmacology, Promoter Regions, Genetic/physiology, Streptomyces/enzymology/*genetics/*metabolism, Transaminases/drug effects/genetics/isolation & purification/*metabolism, Transcription, Genetic/physiologyEnzymology
Enzymology11750062Cloning, heterologous expression and purification of an isocitrate lyase from Streptomyces clavuligerus NRRL 3585.Soh BS, Loke P, Sim TSBiochim Biophys Acta10.1016/s0167-4781(01)00309-82001Bacterial Proteins, Cloning, Molecular, DNA/chemistry, Escherichia coli/genetics/metabolism, Isocitrate Lyase/biosynthesis/*genetics/isolation & purification, Molecular Sequence Data, Open Reading Frames, Operon, Phylogeny, Streptomyces/enzymology/*geneticsPhylogeny
Metabolism12003953CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus.Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, Martin JF, Liras PJ Bacteriol10.1128/JB.184.11.3106-3113.20022002Amino Acid Isomerases/*genetics/metabolism, *Bacterial Proteins, Cephamycins/*biosynthesis, Clavulanic Acid/biosynthesis/*metabolism, DNA-Binding Proteins/*genetics/isolation & purification/metabolism, Genes, Bacterial, Genes, Regulator, Promoter Regions, Genetic, Recombinant Fusion Proteins/metabolism, Streptomyces/*genetics/metabolism, Transcription Factors/metabolismEnzymology
Enzymology15313252Cloning, characterization and heterologous expression of the aspartokinase and aspartate semialdehyde dehydrogenase genes of cephamycin C-producer Streptomyces clavuligerus.Tunca S, Yilmaz EI, Piret J, Liras P, Ozcengiz GRes Microbiol10.1016/j.resmic.2004.03.0072004Aspartate Kinase/antagonists & inhibitors/*genetics/isolation & purification/metabolism, Aspartate-Semialdehyde Dehydrogenase/antagonists & inhibitors/*genetics/isolation & purification/metabolism, Cephamycins/*biosynthesis, Cloning, Molecular, Codon, Initiator, Codon, Terminator, Open Reading Frames/genetics, *Operon, Rifamycins/biosynthesis, Sequence Analysis, DNA, Sequence Homology, Streptomyces/enzymology/*genetics/metabolismMetabolism
Metabolism15464601Cephamycin C production is regulated by relA and rsh genes in Streptomyces clavuligerus ATCC27064.Jin W, Kim HK, Kim JY, Kang SG, Lee SH, Lee KJJ Biotechnol10.1016/j.jbiotec.2004.06.0102004Anti-Bacterial Agents/biosynthesis, Bacterial Proteins/genetics/*metabolism, Cell Culture Techniques/methods, Cell Proliferation, Cephamycins/*biosynthesis, Gene Expression Regulation, Bacterial/physiology, Glycerol/*metabolism, Ligases/genetics/*metabolism, Phosphates/*metabolism, Species Specificity, Streptomyces/*genetics/*physiologyPhylogeny
Genetics16699579Prediction and functional analysis of the replication origin of the linear plasmid pSCL2 in Streptomyces clavuligerus.Wu W, Leblanc SK, Piktel J, Jensen SE, Roy KLCan J Microbiol10.1139/w05-1262006Bacterial Proteins/genetics, Base Sequence, DNA Replication/genetics, DNA, Bacterial/biosynthesis, Molecular Sequence Data, Open Reading Frames/genetics, Plasmids/chemistry/*genetics, Polymerase Chain Reaction, Replication Origin/*genetics/physiology, Replicon/genetics, Restriction Mapping, Sequence Analysis, DNA, Sequence Homology, Nucleic Acid, Streptomyces/*geneticsTranscriptome
Metabolism17625238A statistical approach using L(25) orthogonal array method to study fermentative production of clavulanic acid by Streptomyces clavuligerus MTCC 1142.Saudagar PS, Singhal RSAppl Biochem Biotechnol10.1007/s12010-007-9030-x2007Amino Acids/metabolism, Anti-Bacterial Agents/*biosynthesis, Biotechnology/*methods/*statistics & numerical data, Carbon/chemistry, Clavulanic Acid/*biosynthesis/chemistry, Culture Media/chemistry, Fermentation, Hydrogen-Ion Concentration, Nitrogen/chemistry, Soybean Oil/metabolism, Streptomyces/*metabolismBiotechnology
Metabolism17877708Connecting primary and secondary metabolism: AreB, an IclR-like protein, binds the ARE(ccaR) sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production.Santamarta I, Lopez-Garcia MT, Perez-Redondo R, Koekman B, Martin JF, Liras PMol Microbiol10.1111/j.1365-2958.2007.05937.x2007Acetates/metabolism, Amino Acid Sequence, Bacterial Proteins/genetics/*metabolism, Blotting, Southern, Cephamycins/*metabolism, Clavulanic Acid/*metabolism, Fatty Acids/metabolism, Gene Deletion, Gene Expression Regulation, Bacterial, Leucine/*metabolism, Molecular Sequence Data, Mutation, Operon, Protein Binding, Reverse Transcriptase Polymerase Chain Reaction, Streptomyces/genetics/*metabolism, Transcription, Genetic/geneticsGenetics
Enzymology17909870Targeted disruption of homoserine dehydrogenase gene and its effect on cephamycin C production in Streptomyces clavuligerus.Yilmaz EI, Caydasi AK, Ozcengiz GJ Ind Microbiol Biotechnol10.1007/s10295-007-0259-82007Anti-Bacterial Agents/*biosynthesis, Cephamycins/*biosynthesis, Cloning, Molecular, Culture Media, Escherichia coli/enzymology/genetics, Gene Expression Regulation, Bacterial, *Gene Silencing, Homoserine Dehydrogenase/*genetics/metabolism, Industrial Microbiology/methods, Recombinant Proteins/genetics/isolation & purification/metabolism, Streptomyces/*enzymology/genetics/growth & development/metabolismMetabolism
Metabolism18062234Enhancement of clavulanic acid by replicative and integrative expression of ccaR and cas2 in Streptomyces clavuligerus NRRL3585.Hung TV, Malla S, Park BC, Liou K, Lee HC, Sohng JKJ Microbiol Biotechnol2007Bacterial Proteins/*physiology, Clavulanic Acids/*biosynthesis, *Gene Expression Regulation, Bacterial, Genes, Regulator, Plasmids/genetics, Recombinant Proteins/genetics/metabolism, Streptomyces/genetics/*metabolism
Metabolism18388457Functional effects of increased copy number of the gene encoding proclavaminate amidino hydrolase on clavulanic acid production in Streptomyces clavuligerus ATCC 27064.Song JY, Kim ES, Kim DW, Jensen SE, Lee KJJ Microbiol Biotechnol71692008Bacterial Proteins/genetics/metabolism, Biosynthetic Pathways, Clavulanic Acid/*metabolism, Fermentation, Gene Dosage, *Gene Expression, Gene Expression Regulation, Bacterial, Genetic Vectors, Kinetics, Streptomyces/*enzymology/genetics, Transcription, Genetic, Ureohydrolases/*genetics/*metabolismEnzymology
Biotechnology19011915A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.Song JY, Kim ES, Kim DW, Jensen SE, Lee KJJ Ind Microbiol Biotechnol10.1007/s10295-008-0499-22008Anti-Bacterial Agents/biosynthesis, Bacterial Proteins/*genetics, Biotechnology/methods, Cephamycins/biosynthesis, Clavulanic Acid/*biosynthesis, Culture Media, *Gene Expression Regulation, Bacterial, *Multigene Family, Mutation, Open Reading Frames/genetics, Streptomyces/genetics/*metabolismCultivation
Metabolism19129630An approach to strain improvement and enhanced production of clavulanic acid in Streptomyces clavuligerus.Kim SJ, Kim JO, Shin CH, Park HW, Kim CWBiosci Biotechnol Biochem10.1271/bbb.805692009Clavulanic Acid/*biosynthesis, Fatty Acids, Nonesterified/metabolism, Fermentation, Mutation, Oleic Acid/metabolism, Streptomyces/growth & development/*metabolism, Triolein/metabolismBiotechnology
Genetics19168979A two-component regulatory system involved in clavulanic acid production.Jnawali HN, Oh TJ, Liou K, Park BC, Sohng JKJ Antibiot (Tokyo)10.1038/ja.2008.922008Amino Acid Sequence, Bacterial Proteins/genetics/physiology, Clavulanic Acid/*biosynthesis, DNA, Bacterial/chemistry/genetics, Gene Deletion, Gene Dosage, *Gene Expression Regulation, Bacterial, Gene Order, Genes, Bacterial, Genetic Complementation Test, Molecular Sequence Data, Multigene Family, Sequence Alignment, Sequence Analysis, DNA, Streptomyces/genetics/metabolism/*physiology, Trans-Activators/genetics/*physiologyTranscriptome
Metabolism19286797Glycerol utilization gene cluster in Streptomyces clavuligerus.Banos S, Perez-Redondo R, Koekman B, Liras PAppl Environ Microbiol10.1128/AEM.00181-092009Base Sequence, Clavulanic Acid/biosynthesis, DNA, Bacterial/chemistry/genetics, Gene Deletion, Gene Dosage, Gene Expression Profiling, Gene Order, Genes, Bacterial, Glucose/metabolism, Glycerol/*metabolism, Metabolic Networks and Pathways/*genetics, Molecular Sequence Data, *Multigene Family, Sequence Analysis, DNA, Streptomyces/*genetics/growth & developmentGenetics
Metabolism19374992Chapter 16. Enzymology of beta-lactam compounds with cephem structure produced by actinomycete.Liras P, Demain ALMethods Enzymol10.1016/S0076-6879(09)04816-22009Actinobacteria/*enzymology/genetics/*metabolism, Cephamycins/chemistry/metabolism, Intramolecular Transferases/genetics/metabolism, Molecular Structure, Oxidoreductases/genetics/metabolism, Oxygenases/genetics/metabolism, Penicillin-Binding Proteins/genetics/metabolism, beta-Lactams/chemistry/*metabolismEnzymology
Metabolism20110297The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.Perez-Redondo R, Santamarta I, Bovenberg R, Martin JF, Liras PMicrobiology (Reading)10.1099/mic.0.035840-02010Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Base Sequence, DNA, Bacterial, Escherichia coli/genetics, Genes, Bacterial, Genetic Complementation Test, Glucokinase/genetics/metabolism, Glucose/*metabolism, Molecular Sequence Data, Phosphoenolpyruvate Sugar Phosphotransferase System/*genetics/metabolism, Promoter Regions, Genetic, Recombination, Genetic, Streptomyces/enzymology/genetics/*metabolism, Streptomyces coelicolor/geneticsGenetics
Metabolism20112672[Evaluation of the activities of two promoters in Streptomycetes by reporter gene method].Li J, Xiang S, Yang X, Yang KWei Sheng Wu Xue Bao2009Bacterial Proteins/genetics/metabolism, Base Sequence, Drug Resistance, Bacterial, Gene Expression Regulation, Bacterial, *Genes, Reporter, Molecular Sequence Data, *Promoter Regions, Genetic, Streptomyces/*genetics/metabolismGenetics
Metabolism20134246Enhancement of clavulanic acid production by expressing regulatory genes in gap gene deletion mutant of Streptomyces clavuligerus NRRL3585.Jnawali HN, Lee HC, Sohng JKJ Microbiol BiotechnolJMB020-01-202010Bacterial Proteins/*genetics/metabolism, Clavulanic Acid/*biosynthesis, *Gene Deletion, *Gene Expression Regulation, Bacterial, Genes, Regulator, Glyceraldehyde-3-Phosphate Dehydrogenases/*genetics/metabolism, Glycerol/metabolism, Sequence Deletion, Streptomyces/enzymology/genetics/*metabolismEnzymology
Genetics20624727The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.Medema MH, Trefzer A, Kovalchuk A, van den Berg M, Muller U, Heijne W, Wu L, Alam MT, Ronning CM, Nierman WC, Bovenberg RA, Breitling R, Takano EGenome Biol Evol10.1093/gbe/evq0132010Bacterial Proteins/genetics/metabolism, Chromosomes, Bacterial/genetics, DNA, Bacterial/*genetics, *Evolution, Molecular, Genome, Bacterial, Metabolic Networks and Pathways/*genetics, Models, Biological, Models, Genetic, Molecular Sequence Data, Multigene Family, Phylogeny, Plasmids/*genetics, Replicon, Streptomyces/*genetics/*metabolismMetabolism
Metabolism20870400Role of sigma-factor (orf21) in clavulanic acid production in Streptomyces clavuligerus NRRL3585.Jnawali HN, Liou K, Sohng JKMicrobiol Res10.1016/j.micres.2010.07.0052010Clavulanic Acid/*biosynthesis, Culture Media/chemistry, Gene Expression Profiling, Gene Knockout Techniques, Mutagenesis, Insertional, Reverse Transcriptase Polymerase Chain Reaction, Sigma Factor/genetics/*metabolism, Spores, Bacterial/growth & development, Streptomyces/cytology/genetics/*growth & development/*metabolismBiotechnology
Enzymology20888207Superoxide dismutase (SOD) genes in Streptomyces peucetius: effects of SODs on secondary metabolites production.Kanth BK, Jnawali HN, Niraula NP, Sohng JKMicrobiol Res10.1016/j.micres.2010.07.0032010Anti-Bacterial Agents/biosynthesis, Biomass, Cloning, Molecular, DNA, Bacterial/chemistry/genetics, Gene Expression, Gene Expression Profiling, *Metabolome, Molecular Sequence Data, Sequence Analysis, DNA, Streptomyces/*enzymology/genetics/*metabolism, Superoxide Dismutase/*genetics/*metabolismGenetics
Genetics20889745Draft genome sequence of Streptomyces clavuligerus NRRL 3585, a producer of diverse secondary metabolites.Song JY, Jeong H, Yu DS, Fischbach MA, Park HS, Kim JJ, Seo JS, Jensen SE, Oh TK, Lee KJ, Kim JFJ Bacteriol10.1128/JB.00859-102010Biosynthetic Pathways/genetics, Chromosomes, Bacterial, DNA, Bacterial/*chemistry/*genetics, *Genome, Bacterial, Molecular Sequence Data, Plasmids, Sequence Analysis, DNA/methods, Streptomyces/*geneticsTranscriptome
Metabolism21041678Identification of the gene cluster for the dithiolopyrrolone antibiotic holomycin in Streptomyces clavuligerus.Li B, Walsh CTProc Natl Acad Sci U S A10.1073/pnas.10141401072010Acyltransferases/genetics/metabolism, Anti-Bacterial Agents/*biosynthesis/chemistry, Bacterial Proteins/genetics/metabolism, Computational Biology, Cysteine/metabolism, Enzyme Assays, Gene Deletion, Genes, Bacterial/*genetics, Lactams/chemistry/*metabolism, Multigene Family/*genetics, Open Reading Frames/genetics, Pyrroles/chemistry/*metabolism, Spectrometry, Mass, Electrospray Ionization, Streptomyces/enzymology/*geneticsEnzymology
Enzymology21153459Characterization of the tunicamycin gene cluster unveiling unique steps involved in its biosynthesis.Chen W, Qu D, Zhai L, Tao M, Wang Y, Lin S, Price NP, Deng ZProtein Cell10.1007/s13238-010-0127-62010Actinobacteria/*enzymology/genetics, Base Sequence, Biological Assay, Carbohydrate Sequence, Carbohydrates/*biosynthesis/genetics, Cloning, Molecular, Gene Deletion, Gene Library, High-Throughput Screening Assays, Molecular Sequence Data, Multigene Family, Recombinant Proteins/*biosynthesis/genetics, Sequence Analysis, DNA, Streptomyces/*enzymology/*genetics, Tunicamycin/*biosynthesis/chemistry/geneticsGenetics
Metabolism21326925Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.Ozcengiz G, Okay S, Unsaldi E, Taskin B, Liras P, Piret JBioeng Bugs10.4161/bbug.1.3.112442010Aspartate Kinase/*genetics/metabolism, Bacterial Proteins/*genetics/metabolism, Bioengineering, Cephamycins/*biosynthesis, Culture Media/metabolism, Gene Dosage, *Gene Expression, Homoserine Dehydrogenase/*genetics/metabolism, *Sequence Deletion, Streptomyces/*enzymology/genetics/metabolismEnzymology
Metabolism21342467A rhodanese-like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production.Nardiz N, Santamarta I, Lorenzana LM, Martin JF, Liras PMicrob Biotechnol10.1111/j.1751-7915.2010.00222.x2010Bacterial Proteins/genetics/*metabolism, Cephamycins/biosynthesis, Clavulanic Acid/metabolism, Gene Expression Regulation, Bacterial, Lactams/*metabolism, Membrane Transport Proteins/genetics/*metabolism, *Mutation, Streptomyces/enzymology/genetics/*metabolism, Thiosulfate Sulfurtransferase/genetics/*metabolismBiotechnology
Metabolism21696462Characterization of DNA-binding sequences for CcaR in the cephamycin-clavulanic acid supercluster of Streptomyces clavuligerus.Santamarta I, Lopez-Garcia MT, Kurt A, Nardiz N, Alvarez-Alvarez R, Perez-Redondo R, Martin JF, Liras PMol Microbiol10.1111/j.1365-2958.2011.07743.x2011Binding Sites, Biosynthetic Pathways/genetics, Cephamycins/biosynthesis, Clavulanic Acid/biosynthesis, DNA Footprinting, DNA, Bacterial/*genetics/*metabolism, Electrophoresis, Gel, Two-Dimensional, Electrophoretic Mobility Shift Assay, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Gene Knockout Techniques, *Multigene Family, Mutagenesis, Insertional, RNA, Messenger/biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Streptomyces/*genetics/*metabolism, Trans-Activators/*metabolismEnzymology
Metabolism23109012Prediction of the pho regulon in Streptomyces clavuligerus DSM 738.Salehghamari E, Hamedi J, Elahi E, Sepehrizadeh Z, Sadeghi M, Muth GNew Microbiol2012Bacterial Proteins/chemistry/genetics/metabolism, Base Sequence, Binding Sites, Consensus Sequence, *Gene Expression Regulation, Bacterial, Molecular Sequence Data, Phosphates/metabolism, Promoter Regions, Genetic, Protein Binding, *Regulon, Streptomyces/chemistry/*genetics/metabolismGenetics
Metabolism23147422Transcriptional analysis and proteomics of the holomycin gene cluster in overproducer mutants of Streptomyces clavuligerus.Robles-Reglero V, Santamarta I, Alvarez-Alvarez R, Martin JF, Liras PJ Biotechnol10.1016/j.jbiotec.2012.09.0172012Bacterial Proteins/genetics/metabolism, Gene Expression Profiling/*methods, Lactams/*metabolism, *Multigene Family, Mutation, Proteomics/methods, Streptomyces/*genetics/*metabolism, TranscriptomeTranscriptome
Phylogeny23508694Molecular Analysis of the Clavulanic Acid Regulatory Gene Isolated from an Iranian Strain of Streptomyces Clavuligerus , PTCC 1709.Hojati Z, Salehi Z, Motovali-Bashi M, Korbekandi H, Jami SCell J2011
Metabolism23832248Coordination of glycerol utilization and clavulanic acid biosynthesis to improve clavulanic acid production in Streptomyces clavuligerus.Guo D, Zhao Y, Yang KSci China Life Sci10.1007/s11427-013-4507-z2013Base Sequence, Chemistry, Pharmaceutical/methods, Clavulanic Acid/*biosynthesis, Escherichia coli/metabolism, Gene Expression Regulation, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Glyceraldehyde 3-Phosphate/chemistry, Glycerol/chemistry/*metabolism, Multigene Family, Oligonucleotides/genetics, Operon, Plasmids/metabolism, Promoter Regions, Genetic, Streptomyces/*metabolism, Time FactorsBiotechnology
Metabolism24323287Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus.Liras PAppl Microbiol Biotechnol10.1007/s00253-013-5410-z2013Antibiotics, Antineoplastic/*metabolism, Biosynthetic Pathways/*genetics, Lactams/*metabolism, *Multigene Family, Streptomyces/*genetics/*metabolism
Biotechnology24363725Overproduction of Clavulanic Acid by UV Mutagenesis of Streptomyces clavuligerus.Korbekandi H, Darkhal P, Hojati Z, Abedi D, Hamedi J, Pourhosein MIran J Pharm Res2010
Metabolism24450885Transcriptomic analysis of Streptomyces clavuligerus DeltaccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.Alvarez-Alvarez R, Rodriguez-Garcia A, Santamarta I, Perez-Redondo R, Prieto-Dominguez A, Martinez-Burgo Y, Liras PMicrob Biotechnol10.1111/1751-7915.121092014Biosynthetic Pathways/*genetics, Cephamycins/*metabolism, Clavulanic Acid/*metabolism, Culture Media/chemistry, Gene Deletion, Gene Expression Profiling, *Gene Expression Regulation, Bacterial, Genes, Reporter, Luciferases/analysis/genetics, *Multigene Family, Real-Time Polymerase Chain Reaction, Streptomyces/genetics/growth & development/*metabolism, Transcription Factors/*geneticsCultivation
Metabolism24688492Clavulanic acid production by the MMS 150 mutant obtained from wild type Streptomyces clavuligerus ATCC 27064.da Silva Vasconcelos E, de Lima VA, Goto LS, Cruz-Hernandez IL, Hokka COBraz J Microbiol10.1590/S1517-838220140050000052014Clavulanic Acid/*metabolism, Culture Media/chemistry, Lipase/metabolism, *Metabolic Engineering, Methyl Methanesulfonate, *Mutagenesis, *Mutation, Streptomyces/drug effects/genetics/*metabolism/radiation effects, Ultraviolet RaysBiotechnology
Metabolism24975573Heterologous expression of Streptomyces clavuligerus ATCC 27064 cephamycin C gene cluster.Martinez-Burgo Y, Alvarez-Alvarez R, Perez-Redondo R, Liras PJ Biotechnol10.1016/j.jbiotec.2014.06.0022014Anti-Bacterial Agents/*metabolism/pharmacology, Bacteria/drug effects, Cephamycins/*metabolism/pharmacology, Cloning, Molecular, DNA, Recombinant, Gene Transfer Techniques, Microbial Sensitivity Tests, Multigene Family/*genetics, Streptomyces/*genetics/*metabolismEnzymology
Metabolism25477926Screening of wild type Streptomyces isolates able to overproduce clavulanic acid.Viana Marques DA, Santos-Ebinuma Vde C, de Oliveira PM, Lima GM, Araujo JM, Lima-Filho JL, Converti A, Pessoa-Junior A, Porto ALBraz J Microbiol10.1590/s1517-838220140003000222014Clavulanic Acid/*metabolism, Enterobacter aerogenes/enzymology, Enzyme Inhibitors/*metabolism, Mass Screening, Streptomyces/growth & development/*isolation & purification/*metabolism, beta-Lactamases/metabolismEnzymology
Metabolism26187955The Pathway-Specific Regulator ClaR of Streptomyces clavuligerus Has a Global Effect on the Expression of Genes for Secondary Metabolism and Differentiation.Martinez-Burgo Y, Alvarez-Alvarez R, Rodriguez-Garcia A, Liras PAppl Environ Microbiol10.1128/AEM.00916-152015Bacterial Proteins/genetics/*metabolism, Clavulanic Acid/metabolism, *Gene Expression Regulation, Bacterial, *Secondary Metabolism, Sigma Factor/genetics/metabolism, Streptomyces/genetics/*growth & development/*metabolism, Transcription Factors/genetics/*metabolism, Transcription, Genetic
26469060A method for investigating the stereochemical course of terpene cyclisations.Rabe P, Rinkel J, Klapschinski TA, Barra L, Dickschat JSOrg Biomol Chem10.1039/c5ob01998b2016Cyclization, Molecular Conformation, Stereoisomerism, Terpenes/*chemistry
Genetics26527303Genome-wide identification and characterization of reference genes with different transcript abundances for Streptomyces coelicolor.Li S, Wang W, Li X, Fan K, Yang KSci Rep10.1038/srep158402015Cluster Analysis, Gene Expression Profiling/*methods/standards, *Gene Expression Regulation, Bacterial, Genes, Bacterial/*genetics, Genome, Bacterial/*genetics, Oligonucleotide Array Sequence Analysis/methods/standards, Reference Standards, Reverse Transcriptase Polymerase Chain Reaction/methods/standards, Streptomyces coelicolor/*geneticsTranscriptome
Metabolism26814669Chemical diversity of labdane-type bicyclic diterpene biosynthesis in Actinomycetales microorganisms.Yamada Y, Komatsu M, Ikeda HJ Antibiot (Tokyo)10.1038/ja.2015.1472016Actinomycetales/*enzymology/genetics, Bacterial Proteins/chemistry/genetics/metabolism, Cell Engineering, Cyclization, Databases, Chemical, Diterpenes/chemistry/*metabolism, Streptomyces/geneticsEnzymology
Metabolism30194098Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.Alvarez-Alvarez R, Rodriguez-Garcia A, Martinez-Burgo Y, Martin JF, Liras PAppl Environ Microbiol10.1128/AEM.01701-182018Bacterial Proteins/*genetics/metabolism, Clavulanic Acid/*biosynthesis/chemistry, Clavulanic Acids/metabolism, Gene Expression Regulation, Bacterial, Membrane Transport Proteins/*genetics/metabolism, Multigene Family, Operon, *Sequence Deletion, Streptomyces/*enzymology/genetics/*metabolism, *Transcription, GeneticEnzymology
30456006Impacts of horizontal gene transfer on the compact genome of the clavulanic acid-producing Streptomyces strain F613-1.Li J, Zhao Z, Zhong W, Zhong C, Zong G, Fu J, Cao G3 Biotech10.1007/s13205-018-1498-22018
Metabolism30837970The CagRS Two-Component System Regulates Clavulanic Acid Metabolism via Multiple Pathways in Streptomyces clavuligerus F613-1.Fu J, Qin R, Zong G, Liu C, Kang N, Zhong C, Cao GFront Microbiol10.3389/fmicb.2019.002442019
30891203A putative antimicrobial peptide from Hymenoptera in the megaplasmid pSCL4 of Streptomyces clavuligerus ATCC 27064 reveals a singular case of horizontal gene transfer with potential applications.Ayala-Ruano S, Santander-Gordon D, Tejera E, Perez-Castillo Y, Armijos-Jaramillo VEcol Evol10.1002/ece3.49242019
30984130Activation of Secondary Metabolite Gene Clusters in Streptomyces clavuligerus by the PimM Regulator of Streptomyces natalensis.Martinez-Burgo Y, Santos-Aberturas J, Rodriguez-Garcia A, Barreales EG, Tormo JR, Truman AW, Reyes F, Aparicio JF, Liras PFront Microbiol10.3389/fmicb.2019.005802019
Transcriptome31330947Comparative Transcriptome Analysis of Streptomyces Clavuligerus in Response to Favorable and Restrictive Nutritional Conditions.Pinilla L, Toro LF, Laing E, Alzate JF, Rios-Estepa RAntibiotics (Basel)10.3390/antibiotics80300962019
31352530The two-component system CepRS regulates the cephamycin C biosynthesis in Streptomyces clavuligerus F613-1.Fu J, Qin R, Zong G, Zhong C, Zhang P, Kang N, Qi X, Cao GAMB Express10.1186/s13568-019-0844-z2019
Metabolism32707026Proteomic analysis of a hom-disrupted, cephamycin C overproducing Streptomyces clavuligerus.Unsaldi E, Kurt-Kizildogan A, Ozcan S, Becher D, Voigt B, Aktas C, Ozcengiz GProtein Pept Lett10.2174/09298665276662007231636552021Anti-Bacterial Agents/metabolism, Bacterial Proteins/*metabolism, Cephamycins/*metabolism, Gene Expression Regulation, Bacterial, Homoserine Dehydrogenase/*deficiency/genetics, Proteome/*analysis/*metabolism, Streptomyces/genetics/growth & development/*metabolism, Tandem Mass Spectrometry/*methodsProteome
33947798Elucidating the Regulatory Elements for Transcription Termination and Posttranscriptional Processing in the Streptomyces clavuligerus Genome.Hwang S, Lee N, Choe D, Lee Y, Kim W, Jeong Y, Cho S, Palsson BO, Cho BKmSystems10.1128/mSystems.01013-202021
34747689Genome editing reveals that pSCL4 is required for chromosome linearity in Streptomyces clavuligerus.Gomez-Escribano JP, Algora Gallardo L, Bozhuyuk KAJ, Kendrew SG, Huckle BD, Crowhurst NA, Bibb MJ, Collis AJ, Micklefield J, Herron PR, Wilkinson BMicrob Genom10.1099/mgen.0.0006692021Chromosomes, *Gene Editing/methods, Plasmids/genetics, *Streptomyces/genetics
Genetics35138454Teleocidin-producing genotype of Streptomyces clavuligerus ATCC 27064.Pivk Lukancic P, Drcar T, Bruccoleri R, Crnugelj M, Mrak PAppl Microbiol Biotechnol10.1007/s00253-022-11805-52022Clavulanic Acid, Genotype, *Lyngbya Toxins/metabolism, *Streptomyces/genetics/metabolismMetabolism
Biotechnology35200432Environmental Factors Modulate the Role of orf21 Sigma Factor in Clavulanic Acid Production in Streptomyces Clavuligerus ATCC27064.Patino LF, Aguirre-Hoyos V, Pinilla LI, Toro LF, Rios-Estepa RBioengineering (Basel)10.3390/bioengineering90200782022
Proteome35945361An integrative-omics analysis of an industrial clavulanic acid-overproducing Streptomyces clavuligerus.Kurt-Kizildogan A, Celik G, Unsaldi E, Ozcan S, Ayaz-Guner S, Ozcengiz GAppl Microbiol Biotechnol10.1007/s00253-022-12098-42022Clavulanic Acid, *Gene Expression Regulation, Bacterial, *Proteome/metabolism, Streptomyces, Tandem Mass SpectrometryMetabolism
Metabolism36504789Molecular mechanism of GylR-mediated regulation of glycerol metabolism in Streptomyces clavuligerus NRRL 3585.Zhang C, Zhao Y, Li Z, Wang W, Huang Y, Pan G, Fan KFront Microbiol10.3389/fmicb.2022.10782932022

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