Streptomyces chartreusis (DSM 40085, ATCC 14922, ATCC 19738)

Cell morphology

Multimedia

• @ref:	9298
  multimedia content:	DSM_40085.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40085.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9298	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
9298	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Observation

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
68368	25094 ChEBI	lysine	+	degradation	from API 20E
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
67770	3580 ChEBI	chartreusin
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68368	beta-galactosidase	+	3.2.1.23	from API 20E
68368	gelatinase	+		from API 20E
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	+	3.5.1.5	from API 20E

API 20E

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence KC571198 (>99% sequence identity) for Lactobacillaceae from Microbeatlas

Aquatic Samples	4479
Soil Samples	2696
Animal Samples	29069
Plant Samples	2393
Total Samples	38637

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM870471v1 assembly for Streptomyces chartreusis ATCC 14922	complete	GCA_008704715	1969.6	8109333797	1969	99.72
66792	ASM1465031v1 assembly for Streptomyces chartreusis JCM 4570	scaffold	GCA_014650315	1969.9	8113619664	1969	71.09

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces chartreusis partial 16S rRNA gene, strain ISP 5085	AJ399468	1448		1969
20218	Streptomyces chartreusis gene for 16S ribosomal RNA, partial sequence, strain: JCM 4570	D44239	120		1969
20218	Streptomyces chartreusis gene for 16S rRNA, partial sequence, strain: NBRC 12753	AB184839	1477		1969
20218	Streptomyces chartreusis strain NBRC 12753 16S ribosomal RNA gene, partial sequence	JQ086575	1392		1969
9298	Streptomyces chartreusis strain JCM 4570 16S ribosomal RNA gene, partial sequence	MT760575	1375		1969

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	skandiver: a divergence-based analysis tool for identifying intercellular mobile genetic elements.	Zhang XB, Oualline G, Shaw J, Yu YW.	Bioinformatics	10.1093/bioinformatics/btae398	2024
	Genome Mining and Gene Expression Reveal Maytansine Biosynthetic Genes from Endophytic Communities Living inside Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. and the Relationship with the Plant Biosynthetic Gene, Friedelin Synthase.	Pitakbut T, Spiteller M, Kayser O.	Plants (Basel)	10.3390/plants11030321	2022
Enzymology	Strepchazolins A and B: Two New Alkaloids from a Marine Streptomyces chartreusis NA02069.	Yang CL, Wang YS, Liu CL, Zeng YJ, Cheng P, Jiao RH, Bao SX, Huang HQ, Tan RX, Ge HM.	Mar Drugs	10.3390/md15080244	2017
	Atmospheric Precipitations, Hailstone and Rainwater, as a Novel Source of Streptomyces Producing Bioactive Natural Products.	Sarmiento-Vizcaino A, Espadas J, Martin J, Brana AF, Reyes F, Garcia LA, Blanco G.	Front Microbiol	10.3389/fmicb.2018.00773	2018
Phylogeny	Serological analysis of morphologically and biochemically similar Streptomyces species.	Guthrie RK, Kocsis I, Lassiter CB.	Appl Microbiol	10.1128/am.21.4.643-646.1971	1971
	Intimate relationships among actinomycetes and mycolic acid-containing bacteria.	Kato M, Asamizu S, Onaka H.	Sci Rep	10.1038/s41598-022-11406-2	2022
Pathogenicity	Anti-Candida properties of urauchimycins from actinobacteria associated with trachymyrmex ants.	Mendes TD, Borges WS, Rodrigues A, Solomon SE, Vieira PC, Duarte MC, Pagnocca FC.	Biomed Res Int	10.1155/2013/835081	2013
	DNA relatedness among strains of the sweet potato pathogen Streptomyces ipomoea (Person and Martin 1940) Waksman and Henrici 1948.	Labeda DP, Lyons AJ.	Appl Environ Microbiol	10.1128/aem.58.2.532-535.1992	1992
Metabolism	Chartreusin: production and microbiological assay.	Hanka LJ, Gerpheide SA.	Antimicrob Agents Chemother	10.1128/aac.12.5.571	1977
Phylogeny	STREPTOMYCES SPECIES COMPRISING THE BLUE-SPORE SERIES.	TREJO WH, BENNETT RE.	J Bacteriol	10.1128/jb.85.3.676-690.1963	1963
	An evaluation of criteria and procedures used in the description and characterization of the Streptomycetes. A cooperative study.	GOTTLIEB D.	Appl Microbiol	10.1128/am.9.1.55-65.1961	1961
Phylogeny	Re-classification of Streptomyces venezuelae strains and mining secondary metabolite biosynthetic gene clusters.	Lee N, Choi M, Kim W, Hwang S, Lee Y, Kim JH, Kim G, Kim H, Cho S, Kim SC, Palsson B, Jang KS, Cho BK.	iScience	10.1016/j.isci.2021.103410	2021
	(3R)-obscurolide A: a new obscurolide from Streptomyces chartreusis SA-7 isolated from soil of the North Western Himalayas.	Manhas RS, Sharma N, Begum S, Nalli Y, Chaubey A.	Nat Prod Res	10.1080/14786419.2025.2477807	2025
	Antibacterial and Anti-Inflammatory Properties of Flavonoids from Streptomyces chartreusis RH3.5.	Taechowisan T, Chuen-Im T, Phutdhawong WS.	Pak J Biol Sci	10.3923/pjbs.2024.244.255	2024
	Evaluation of the cytotoxicity and antibacterial activity of a synthetic tunicamycin derivative against Mycobacterium avium complex.	Colombatti Olivieri MA, Price NPJ, Jackson MA, Bannantine JP.	Front Microbiol	10.3389/fmicb.2025.1604400	2025
	Inter domain interactions influence the substrate affinity and hydrolysis product specificity of xylanase from Streptomyces chartreusis L1105	Xiong K, Yan Zx, Liu Jy, Pei Pg, Deng L, Gao L, Sun Bg.	Ann Microbiol		2020
	Bacteriophage-Mediated Risk Pathways Underlying the Emergence of Antimicrobial Resistance via Intrageneric and Intergeneric Recombination of Antibiotic Efflux Genes Across Natural populations of Human Pathogenic Bacteria.	Gabashvili E, Kobakhidze S, Chkhikvishvili T, Tabatadze L, Tsiklauri R, Dadiani K, Kotetishvili M.	Microb Ecol	10.1007/s00248-021-01846-0	2022
Enzymology	Discovery of three novel sesquiterpene synthases from Streptomyces chartreusis NRRL 3882 and crystal structure of an alpha-eudesmol synthase.	Kracht ON, Correia Cordeiro RS, Hakansson M, Stockmann J, Sander D, Bandow J, Senges CHR, Logan DT, Kourist R.	J Biotechnol	10.1016/j.jbiotec.2019.03.006	2019
Genetics	Draft genome sequence of Streptomyces sp. KD18, isolated from industrial soil.	Khushboo, Singhvi N, Gupta V, Dhaka N, Dubey KK.	3 Biotech	10.1007/s13205-022-03453-3	2023
	Collective total synthesis of chartreusin derivatives and bioactivity investigations.	Yi HZ, Liang SM, Li JJ, Liu H, Liao JX, Liu DY, Zhang QJ, Cai MZ, Sun JS.	Chem Sci	10.1039/d4sc05629a	2025
Metabolism	Synthesis of cinnabarinic acid by metabolically engineered Pseudomonas chlororaphis GP72.	Yue SJ, Song C, Li S, Huang P, Guo SQ, Hu HB, Wang W, Zhang XH.	Biotechnol Bioeng	10.1002/bit.27118	2019
Proteome	Influence of Amino Acid Feeding on Production of Calcimycin and Analogs in Streptomyces chartreusis.	Arend KI, Bandow JE.	Int J Environ Res Public Health	10.3390/ijerph18168740	2021
	Generation of New Complestatin Analogues by Heterologous Expression of the Complestatin Biosynthetic Gene Cluster from Streptomyces chartreusis AN1542.	Park OK, Choi HY, Kim GW, Kim WG.	Chembiochem	10.1002/cbic.201600241	2016
	Possible Role of CHAD Proteins in Copper Resistance.	Gonzalez-Madrid G, Navarro CA, Acevedo-Lopez J, Orellana LH, Jerez CA.	Microorganisms	10.3390/microorganisms12020409	2024
	The Identification and Conservation of Tunicaminyluracil-Related Biosynthetic Gene Clusters in Several Rathayibacter Species Collected From Australia, Africa, Eurasia, and North America.	Tancos MA, Sechler AJ, Davis EW, Chang JH, Schroeder BK, Murray TD, Rogers EE.	Front Microbiol	10.3389/fmicb.2019.02914	2019
Enzymology	[Isolation and antimicrobial activities of actinomycetes from vermicompost].	Wang XJ, Yan SL, Min CL, Yang Y.	Zhongguo Zhong Yao Za Zhi	10.4268/cjcmm20150408	2015
Enzymology	Characterization of the N-methyltransferase CalM involved in calcimycin biosynthesis by Streptomyces chartreusis NRRL 3882.	Wu Q, Gou L, Lin S, Liang J, Yin J, Zhou X, Bai L, An D, Deng Z, Wang Z.	Biochimie	10.1016/j.biochi.2013.03.014	2013
Metabolism	Complestatin exerts antibacterial activity by the inhibition of fatty acid synthesis.	Kwon YJ, Kim HJ, Kim WG.	Biol Pharm Bull	10.1248/bpb.b14-00824	2015
	Diversity and Screening of Cellulolytic Microorganisms from Mangrove Forests, Natural Parks, Paddy Field, and Sugarcane Plantation in Panay Island, Philippines.	Gatpatan IGT, Cabulong RB, Sadaba RB.	Int J Microbiol	10.1155/2024/5573158	2024
	Establishment of a novel ER-stress induced myopia model in mice.	Kang L, Ikeda SI, Yang Y, Jeong H, Chen J, Zhang Y, Negishi K, Tsubota K, Kurihara T.	Eye Vis (Lond)	10.1186/s40662-023-00361-2	2023
Metabolism	Structural and biochemical analysis of a phosin from Streptomyces chartreusis reveals a combined polyphosphate- and metal-binding fold.	Werten S, Rustmeier NH, Gemmer M, Virolle MJ, Hinrichs W.	FEBS Lett	10.1002/1873-3468.13476	2019
Metabolism	The secreted metabolome of Streptomyces chartreusis and implications for bacterial chemistry.	Senges CHR, Al-Dilaimi A, Marchbank DH, Wibberg D, Winkler A, Haltli B, Nowrousian M, Kalinowski J, Kerr RG, Bandow JE.	Proc Natl Acad Sci U S A	10.1073/pnas.1715713115	2018
Enzymology	Properties of an alkaline-tolerant, thermostable xylanase from Streptomyces chartreusis L1105, suitable for xylooligosaccharide production.	Zhu Y, Li X, Sun B, Song H, Li E, Song H.	J Food Sci	10.1111/j.1750-3841.2012.02671.x	2012
Genetics	Draft Genome Analysis Offers Insights Into the Mechanism by Which Streptomyces chartreusis WZS021 Increases Drought Tolerance in Sugarcane.	Wang Z, Solanki MK, Yu ZX, Yang LT, An QL, Dong DF, Li YR.	Front Microbiol	10.3389/fmicb.2018.03262	2018
Genetics	MariClus: Your One-Stop Platform for Information on Marine Natural Products, Their Gene Clusters and Producing Organisms.	Hermans C, De Mol ML, Mispelaere M, De Rop AS, Rombaut J, Nusayr T, Creamer R, De Maeseneire SL, Soetaert WK, Hulpiau P.	Mar Drugs	10.3390/md21080449	2023
	Analysis of the Tunicamycin Biosynthetic Gene Cluster of Streptomyces chartreusis Reveals New Insights into Tunicamycin Production and Immunity.	Widdick D, Royer SF, Wang H, Vior NM, Gomez-Escribano JP, Davis BG, Bibb MJ.	Antimicrob Agents Chemother	10.1128/aac.00130-18	2018
	Characterization and utilization of methyltransferase for apramycin production in Streptoalloteichus tenebrarius.	Sun J, Gao H, Yan D, Liu Y, Ni X, Xia H.	J Ind Microbiol Biotechnol	10.1093/jimb/kuac011	2022
	Advancement in the molecular perspective of plant-endophytic interaction to mitigate drought stress in plants.	Salvi P, Mahawar H, Agarrwal R, Kajal, Gautam V, Deshmukh R.	Front Microbiol	10.3389/fmicb.2022.981355	2022
Metabolism	Cezomycin Is Activated by CalC to Its Ester Form for Further Biosynthesis Steps in the Production of Calcimycin in Streptomyces chartreusis NRRL 3882.	Wu H, Liang J, Wang J, Liang WJ, Gou L, Wu Q, Zhou X, Bruce IJ, Deng Z, Wang Z.	Appl Environ Microbiol	10.1128/aem.00586-18	2018
	Baeyer-Villiger oxidation: a promising tool for the synthesis of natural products: a review.	Fatima S, Zahoor AF, Khan SG, Naqvi SAR, Hussain SM, Nazeer U, Mansha A, Ahmad H, Chaudhry AR, Irfan A.	RSC Adv	10.1039/d4ra03914a	2024
Genetics	A Functional Carbohydrate Degrading Enzyme Potentially Acquired by Horizontal Gene Transfer in the Genome of the Soil Invertebrate Folsomia candida.	Le NG, van Ulsen P, van Spanning R, Brouwer A, van Straalen NM, Roelofs D.	Genes (Basel)	10.3390/genes13081402	2022
Genetics	Genome Characteristics Reveal the Biocontrol Potential of Actinobacteria Isolated From Sugarcane Rhizosphere.	Wang Z, Solanki MK, Yu ZX, Anas M, Dong DF, Xing YX, Malviya MK, Pang F, Li YR.	Front Microbiol	10.3389/fmicb.2021.797889	2021
	Halogenated volatiles from the fungus Geniculosporium and the actinomycete Streptomyces chartreusis.	Wang T, Rabe P, Citron CA, Dickschat JS.	Beilstein J Org Chem	10.3762/bjoc.9.311	2013
Genetics	Comparative Metagenomic Study of Rhizospheric and Bulk Mercury-Contaminated Soils in the Mining District of Almadén.	Gonzalez D, Robas M, Fernandez V, Barcena M, Probanza A, Jimenez PA.	Front Microbiol	10.3389/fmicb.2022.797444	2022
Genetics	Whole genome sequence of two Rathayibacter toxicus strains reveals a tunicamycin biosynthetic cluster similar to Streptomyces chartreusis.	Sechler AJ, Tancos MA, Schneider DJ, King JG, Fennessey CM, Schroeder BK, Murray TD, Luster DG, Schneider WL, Rogers EE.	PLoS One	10.1371/journal.pone.0183005	2017
	Comparative and pangenomic analysis of the genus Streptomyces.	Otani H, Udwary DW, Mouncey NJ.	Sci Rep	10.1038/s41598-022-21731-1	2022
	Halotolerant Marine Rhizosphere-Competent Actinobacteria Promote Salicornia bigelovii Growth and Seed Production Using Seawater Irrigation.	Mathew BT, Torky Y, Amin A, Mourad AI, Ayyash MM, El-Keblawy A, Hilal-Alnaqbi A, AbuQamar SF, El-Tarabily KA.	Front Microbiol	10.3389/fmicb.2020.00552	2020
Pathogenicity	Synthesis and biological evaluation of diversely substituted indolin-2-ones.	Bouchikhi F, Rossignol E, Sancelme M, Aboab B, Anizon F, Fabbro D, Prudhomme M, Moreau P.	Eur J Med Chem	10.1016/j.ejmech.2008.01.010	2008
	Salicornia bigelovii, S. brachiata and S. herbacea: Their Nutritional Characteristics and an Evaluation of Their Potential as Salt Substitutes.	Alfheeaid HA, Raheem D, Ahmed F, Alhodieb FS, Alsharari ZD, Alhaji JH, BinMowyna MN, Saraiva A, Raposo A.	Foods	10.3390/foods11213402	2022
	Effects of 4-Br-A23187 on Bacillus subtilis cells and unilamellar vesicles reveal it to be a potent copper ionophore.	Senges CHR, Warmuth HL, Vazquez-Hernandez M, Uzun HD, Sagurna L, Dietze P, Schmidt C, Mucher B, Herlitze S, Kramer U, Ott I, Gunther Pomorski T, Bandow JE.	Proteomics	10.1002/pmic.202200061	2022
Pathogenicity	Antimicrobial compounds from marine actinomycetes.	Wang C, Lu Y, Cao S.	Arch Pharm Res	10.1007/s12272-020-01251-0	2020
Biotechnology	Design and synthesis of small molecular 2-aminobenzoxazoles as potential antifungal agents against phytopathogenic fungi.	Fan L, Luo Z, Yang C, Guo B, Miao J, Chen Y, Tang L, Li Y.	Mol Divers	10.1007/s11030-021-10213-7	2022
Metabolism	A Regulator Based "Semi-Targeted" Approach to Activate Silent Biosynthetic Gene Clusters.	Mingyar E, Muhling L, Kulik A, Winkler A, Wibberg D, Kalinowski J, Blin K, Weber T, Wohlleben W, Stegmann E.	Int J Mol Sci	10.3390/ijms22147567	2021
Metabolism	Biosynthesis of the antitumor agent chartreusin involves the oxidative rearrangement of an anthracyclic polyketide.	Xu Z, Jakobi K, Welzel K, Hertweck C.	Chem Biol	10.1016/j.chembiol.2005.04.017	2005
	Actinobacteria from Termite Mounds Show Antiviral Activity against Bovine Viral Diarrhea Virus, a Surrogate Model for Hepatitis C Virus.	Padilla MA, Rodrigues RA, Bastos JC, Martini MC, Barnabe AC, Kohn LK, Uetanabaro AP, Bomfim GF, Afonso RS, Fantinatti-Garboggini F, Arns CW.	Evid Based Complement Alternat Med	10.1155/2015/745754	2015
	Synthesis and biological evaluation of oxindoles and benzimidazolinones derivatives.	Messaoudi S, Sancelme M, Polard-Housset V, Aboab B, Moreau P, Prudhomme M.	Eur J Med Chem	10.1016/j.ejmech.2004.01.001	2004
	Targeting SARS-CoV-2 non-structural protein 13 via helicase-inhibitor-repurposing and non-structural protein 16 through pharmacophore-based screening.	Samdani MN, Morshed N, Reza R, Asaduzzaman M, Islam ABMMK.	Mol Divers	10.1007/s11030-022-10468-8	2023
	Tyrosol blocks E. coli anaerobic biofilm formation via YbfA and FNR to increase antibiotic susceptibility.	Choi HY, Kim WG.	Nat Commun	10.1038/s41467-024-50116-3	2024
Metabolism	Conformational analysis of chirally deuterated tunicamycin as an active site probe of UDP-N-acetylhexosamine:polyprenol-P N-acetylhexosamine-1-P translocases.	Xu L, Appell M, Kennedy S, Momany FA, Price NP.	Biochemistry	10.1021/bi048327q	2004
	Rebeccamycin analogues bearing amine substituents or other groups on the sugar moiety.	Anizon F, Moreau P, Sancelme M, Laine W, Bailly C, Prudhomme M.	Bioorg Med Chem	10.1016/s0968-0896(03)00343-2	2003
	Cross-Bioaugmentation Among Four Remote Soil Samples Contaminated With Oil Exerted Just Inconsistent Effects on Oil-Bioremediation.	Al-Mailem DM, Kansour MK, Radwan SS.	Front Microbiol	10.3389/fmicb.2019.02827	2019
Metabolism	Identification of nocamycin biosynthetic gene cluster from Saccharothrix syringae NRRL B-16468 and generation of new nocamycin derivatives by manipulating gene cluster.	Mo X, Shi C, Gui C, Zhang Y, Ju J, Wang Q.	Microb Cell Fact	10.1186/s12934-017-0718-5	2017
	Enhanced endoxylanase production by Myceliophthora thermophila with applicability in saccharification of agricultural substrates.	Dahiya S, Singh B.	3 Biotech	10.1007/s13205-019-1750-4	2019
	Antimicrobial and enzymatic activity of actinomycetes isolated from soils of coastal islands.	Charousova I, Medo J, Halenarova E, Javorekova S.	J Adv Pharm Technol Res	10.4103/japtr.japtr_161_16	2017
	Synthesis and biological activities of indolocarbazoles bearing amino acid residues.	Moreau P, Sancelme M, Bailly C, Leonce S, Pierre A, Hickman J, Pfeiffer B, Prudhomme M.	Eur J Med Chem	10.1016/s0223-5234(01)01284-3	2001
Pathogenicity	The Nitrite Transporter Facilitates Biofilm Formation via Suppression of Nitrite Reductase and Is a New Antibiofilm Target in Pseudomonas aeruginosa.	Park JS, Choi HY, Kim WG.	mBio	10.1128/mbio.00878-20	2020
Enzymology	Mutanase Enzyme from Paracoccus mutanolyticus RSP02: Characterization and Application as a Biocontrol Agent.	Buddana SK, Amrutha RN, Batchu UR, Penna S, Prakasham RS.	Indian J Microbiol	10.1007/s12088-019-00821-1	2019
	Scleral PERK and ATF6 as targets of myopic axial elongation of mouse eyes.	Ikeda SI, Kurihara T, Jiang X, Miwa Y, Lee D, Serizawa N, Jeong H, Mori K, Katada Y, Kunimi H, Ozawa N, Shoda C, Ibuki M, Negishi K, Torii H, Tsubota K.	Nat Commun	10.1038/s41467-022-33605-1	2022
Proteome	Differential Protein Expression Analysis of Two Sugarcane Varieties in Response to Diazotrophic Plant Growth-Promoting Endophyte Enterobacter roggenkampii ED5.	Guo DJ, Li DP, Singh RK, Singh P, Sharma A, Verma KK, Qin Y, Khan Q, Lu Z, Malviya MK, Song XP, Xing YX, Li YR.	Front Plant Sci	10.3389/fpls.2021.727741	2021
Metabolism	In Vivo Studies of Inoculated Plants and In Vitro Studies Utilizing Methanolic Extracts of Endophytic Streptomyces sp. Strain DBT34 Obtained from Mirabilis jalapa L. Exhibit ROS-Scavenging and Other Bioactive Properties.	Passari AK, Leo VV, Singh G, Samanta L, Ram H, Siddaiah CN, Hashem A, Al-Arjani AF, Alqarawi AA, Fathi Abd Allah E, Singh BP.	Int J Mol Sci	10.3390/ijms21197364	2020
Metabolism	Chrymutasins: novel-aglycone antitumor antibiotics from a mutant of Streptomyces chartreusis. II. Characterization and structural elucidation.	Uchida H, Nakakita Y, Enoki N, Abe N, Nakamura T, Munekata M.	J Antibiot (Tokyo)	10.7164/antibiotics.47.655	1994
	Bioactive Potential of Several Actinobacteria Isolated from Microbiologically Barely Explored Desert Habitat, Saudi Arabia.	Almuhayawi MS, Mohamed MSM, Abdel-Mawgoud M, Selim S, Al Jaouni SK, AbdElgawad H.	Biology (Basel)	10.3390/biology10030235	2021
Metabolism	Chrymutasins: novel-aglycone antitumor antibiotics from a mutant of Streptomyces chartreusis. I. Taxonomy, mutation, fermentation, isolation and biological activities.	Uchida H, Nakakita Y, Enoki N, Abe N, Nakamura T, Munekata M.	J Antibiot (Tokyo)	10.7164/antibiotics.47.648	1994
	Purification and primary structure of proteinous alpha-amylase inhibitor from Streptomyces chartreusis.	Katsuyama K, Iwata N, Shimazu A.	Biosci Biotechnol Biochem	10.1271/bbb.56.1949	1992
	Syntheses and biological activities of rebeccamycin analogues. Introduction of a halogenoacetyl substituent.	Moreau P, Anizon F, Sancelme M, Prudhomme M, Bailly C, Severe D, Riou JF, Fabbro D, Meyer T, Aubertin AM.	J Med Chem	10.1021/jm980396d	1999
	Syntheses and biological evaluation of indolocarbazoles, analogues of rebeccamycin, modified at the imide heterocycle.	Moreau P, Anizon F, Sancelme M, Prudhomme M, Bailly C, Carrasco C, Ollier M, Severe D, Riou JF, Fabbro D, Meyer T, Aubertin AM.	J Med Chem	10.1021/jm970843+	1998
	Syntheses and antimicrobial activities of five-membered ring heterocycles coupled to indole moieties.	Pereira ER, Sancelme M, Towa JJ, Prudhomme M, Martre AM, Mousset G, Rapp M.	J Antibiot (Tokyo)	10.7164/antibiotics.49.380	1996
Enzymology	Crystallization and preliminary crystallographic analysis of exo-alpha-1,5-L-arabinofuranosidase from Streptomyces avermitilis NBRC14893.	Fujimoto Z, Ichinose H, Kaneko S.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309108029692	2008
	Structure-activity relationships in a series of substituted indolocarbazoles: topoisomerase I and protein kinase C inhibition and antitumoral and antimicrobial properties.	Pereira ER, Belin L, Sancelme M, Prudhomme M, Ollier M, Rapp M, Severe D, Riou JF, Fabbro D, Meyer T.	J Med Chem	10.1021/jm9603779	1996
	Syntheses and biological activities (topoisomerase inhibition and antitumor and antimicrobial properties) of rebeccamycin analogues bearing modified sugar moieties and substituted on the imide nitrogen with a methyl group.	Anizon F, Belin L, Moreau P, Sancelme M, Voldoire A, Prudhomme M, Ollier M, Severe D, Riou JF, Bailly C, Fabbro D, Meyer T.	J Med Chem	10.1021/jm9702084	1997
	Decoding Catalysis by Terpene Synthases.	Whitehead JN, Leferink NGH, Johannissen LO, Hay S, Scrutton NS.	ACS Catal	10.1021/acscatal.3c03047	2023
	Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors. II. Substitution on maleimide nitrogen with functional groups bearing a labile hydrogen.	Pereira ER, Fabre S, Sancelme M, Prudhomme M, Rapp M.	J Antibiot (Tokyo)	10.7164/antibiotics.48.863	1995
	Antimicrobial activities of indolocarbazole and bis-indole protein kinase C inhibitors.	Sancelme M, Fabre S, Prudhomme M.	J Antibiot (Tokyo)	10.7164/antibiotics.47.792	1994
Enzymology	A new antitumor antibiotic product, demethylchartreusin. Isolation and biological activities.	Aoyama Y, Katayama T, Yamamoto M, Tanaka H, Kon K.	J Antibiot (Tokyo)	10.7164/antibiotics.45.875	1992
Biotechnology	Marine Actinobacteria a New Source of Antibacterial Metabolites to Treat Acne Vulgaris Disease-A Systematic Literature Review.	De La Hoz-Romo MC, Diaz L, Villamil L.	Antibiotics (Basel)	10.3390/antibiotics11070965	2022
Enzymology	Purification, characterization and gene cloning of two alpha-L-arabinofuranosidases from streptomyces chartreusis GS901.	Matsuo N, Kaneko S, Kuno A, Kobayashi H, Kusakabe I.	Biochem J	10.1042/bj3460009	2000
Metabolism	Discovery, isolation and structure of novel cephamycins of Streptomyces chartreusis.	Inouye S, Kojima M, Shomura T, Iwamatsu K, Niwa T, Kondo Y, Niida T, Ogawa Y, Kusama K.	J Antibiot (Tokyo)	10.7164/antibiotics.36.115	1983
Genetics	Comparative Genomic Analysis Confirms Five Genetic Populations of the Select Agent, Rathayibacter toxicus.	Yasuhara-Bell J, Arif M, Busot GY, Mann R, Rodoni B, Stack JP.	Microorganisms	10.3390/microorganisms8030366	2020
Enzymology	Characterization of novel glycosyl hydrolases discovered by cell wall glycan directed monoclonal antibody screening and metagenome analysis of maize aerial root mucilage.	Pozzo T, Higdon SM, Pattathil S, Hahn MG, Bennett AB.	PLoS One	10.1371/journal.pone.0204525	2018
Metabolism	Staphylococcus aureus Panton-Valentine Leukocidin triggers an alternative NETosis process targeting mitochondria.	Mazzoleni V, Zimmermann K, Smirnova A, Tarassov I, Prevost G.	FASEB J	10.1096/fj.201902981r	2021
Metabolism	Secreted Alpha-N-Arabinofuranosidase B Protein Is Required for the Full Virulence of Magnaporthe oryzae and Triggers Host Defences.	Wu J, Wang Y, Park SY, Kim SG, Yoo JS, Park S, Gupta R, Kang KY, Kim ST.	PLoS One	10.1371/journal.pone.0165149	2016
Metabolism	Distinct actions by Paenibacillus sp. strain E18 alpha-L-arabinofuranosidases and xylanase in xylan degradation.	Shi P, Chen X, Meng K, Huang H, Bai Y, Luo H, Yang P, Yao B.	Appl Environ Microbiol	10.1128/aem.03276-12	2013
Pathogenicity	Cloning of antibiotic-resistance genes in Streptomyces.	Murakami T, Nojiri C, Toyama H, Hayashi E, Katumata K, Anzai H, Matsuhashi Y, Yamada Y, Nagaoka K.	J Antibiot (Tokyo)	10.7164/antibiotics.36.1305	1983
	Effect of chartreusin on macromolecular synthesis.	Obrig T, Frenkel GD.	Res Commun Chem Pathol Pharmacol		1981
Metabolism	Hydroheptin: a water-soluble polyene macrolide. I. Taxonomy, fermentation and isolation.	Tunac JB, McDaniel LE, Schaffner CP.	J Antibiot (Tokyo)	10.7164/antibiotics.32.1223	1979
	Hydroheptin: a water-soluble polyene macrolide. II. Chemical and biological properties.	Tunac JB, McDaniel LE, Patel M, Schaffner CP.	J Antibiot (Tokyo)	10.7164/antibiotics.32.1230	1979
Metabolism	Structures of DPAGT1 Explain Glycosylation Disease Mechanisms and Advance TB Antibiotic Design.	Dong YY, Wang H, Pike ACW, Cochrane SA, Hamedzadeh S, Wyszynski FJ, Bushell SR, Royer SF, Widdick DA, Sajid A, Boshoff HI, Park Y, Lucas R, Liu WM, Lee SS, Machida T, Minall L, Mehmood S, Belaya K, Liu WW, Chu A, Shrestha L, Mukhopadhyay SMM, Strain-Damerell C, Chalk R, Burgess-Brown NA, Bibb MJ, Barry Iii CE, Robinson CV, Beeson D, Davis BG, Carpenter EP.	Cell	10.1016/j.cell.2018.10.037	2018
Enzymology	Structural insight into the ligand specificity of a thermostable family 51 arabinofuranosidase, Araf51, from Clostridium thermocellum.	Taylor EJ, Smith NL, Turkenburg JP, D'Souza S, Gilbert HJ, Davies GJ.	Biochem J	10.1042/bj20051780	2006
Enzymology	Characterization of a modular enzyme of exo-1,5-alpha-L-arabinofuranosidase and arabinan binding module from Streptomyces avermitilis NBRC14893.	Ichinose H, Yoshida M, Fujimoto Z, Kaneko S.	Appl Microbiol Biotechnol	10.1007/s00253-008-1551-x	2008
Metabolism	Streptomyces Volatile Compounds Influence Exploration and Microbial Community Dynamics by Altering Iron Availability.	Jones SE, Pham CA, Zambri MP, McKillip J, Carlson EE, Elliot MA.	mBio	10.1128/mbio.00171-19	2019
Enzymology	Crystal structure of an Exo-1,5-{alpha}-L-arabinofuranosidase from Streptomyces avermitilis provides insights into the mechanism of substrate discrimination between exo- and endo-type enzymes in glycoside hydrolase family 43.	Fujimoto Z, Ichinose H, Maehara T, Honda M, Kitaoka M, Kaneko S.	J Biol Chem	10.1074/jbc.m110.164251	2010
Metabolism	Family shuffling of expandase genes to enhance substrate specificity for penicillin G.	Hsu JS, Yang YB, Deng CH, Wei CL, Liaw SH, Tsai YC.	Appl Environ Microbiol	10.1128/aem.70.10.6257-6263.2004	2004
Enzymology	Purification and properties of endo-alpha-1,3-glucanase from a Streptomyces chartreusis strain.	Takehara T, Inoue M, Morioka T, Yokogawa K.	J Bacteriol	10.1128/jb.145.2.729-735.1981	1981
Metabolism	Microbial transformation of A23187, a divalent cation ionophore antibiotic.	Abbott BJ, Fukuda DS, Dorman DE, Occolowitz JL, Debono M, Farhner L.	Antimicrob Agents Chemother	10.1128/aac.16.6.808	1979
Enzymology	Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in Toxoplasma gondii.	Kemp LE, Rusch M, Adibekian A, Bullen HE, Graindorge A, Freymond C, Rottmann M, Braun-Breton C, Baumeister S, Porfetye AT, Vetter IR, Hedberg C, Soldati-Favre D.	J Biol Chem	10.1074/jbc.m113.460709	2013
Metabolism	Identification of a gene negatively affecting antibiotic production and morphological differentiation in Streptomyces coelicolor A3(2).	Li W, Ying X, Guo Y, Yu Z, Zhou X, Deng Z, Kieser H, Chater KF, Tao M.	J Bacteriol	10.1128/jb.00933-06	2006
Phylogeny	Streptomyces ziwulingensis sp. nov., isolated from grassland soil.	Lin YB, Wang XY, Wang TT, An SS, Shi P, Wei GH	Int J Syst Evol Microbiol	10.1099/ijs.0.043026-0	2012
Phylogeny	Streptomyces qaidamensis sp. nov., isolated from sand in the Qaidam Basin, China.	Zhang B, Tang S, Chen X, Zhang G, Zhang W, Chen T, Liu G, Li S, Dos Santos LT, Castro HC, Facey P, Hitchings M, Dyson P	J Antibiot (Tokyo)	10.1038/s41429-018-0080-9	2018
Phylogeny	Streptomyces rhizosphaerihabitans sp. nov. and Streptomyces adustus sp. nov., isolated from bamboo forest soil.	Lee HJ, Whang KS	Int J Syst Evol Microbiol	10.1099/ijsem.0.001236	2016
Phylogeny	Streptomyces graminifolii sp. nov., isolated from bamboo (Sasa borealis) litter.	Lee HJ, Whang KS	Int J Syst Evol Microbiol	10.1099/ijs.0.056895-0	2014
Phylogeny	Streptomyces osmaniensis sp. nov., isolated from soil.	Reddy TVK, Mahmood S, Idris MM, Ciesielski S	Int J Syst Evol Microbiol	10.1099/ijs.0.017749-0	2009