Streptococcus infantis (DSM 12492, ATCC 700779, JCM 10157)

Name: Streptococcus infantis (DSM 12492, ATCC 700779, JCM 10157)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14806

Type strain

Strain Designation O-122

Culture col. no. DSM 12492 ATCC 700779 JCM 10157 CCUG 39817 LMG 18720 4 more

NCBI tax ID(s) 889204 68892

Special Collections DSMZ CCUG JCM CIP

History DSMZ <- JCM <- Y. Kawamura; GTC 849 <- H. Ohkuni; O-122 JCM <-- Y. Kawamura GTC 849 <-- H. Ohkuni O-122. CIP <- 1999, JCM <- Y. Kawamura: strain GTC849 <- H. Ohkuni: strain O-122

Links

Streptococcus infantis O-122 is a microaerophile, Gram-positive, coccus-shaped bacterium that was isolated from human tooth surface.

Gram-positive coccus-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 92415

LMG 18720,JCM 10157,NCTC 13771,ATCC 700779,CIP 105949,DSM 12492,CCUG 39817,CCM 7373

@ref 20215

Last LPSN update 2026-05-29 08:28:22

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus infantis

Full scientific name Streptococcus infantis Kawamura et al. 1998

BacDive ID	Other strains from **Streptococcus infantis** (20)	Type strain
144103	S. infantis CCUG 23055
144595	S. infantis CCUG 25857
145064	S. infantis CCUG 27568
145404	S. infantis CCUG 28372
147124	S. infantis CCUG 32905
147261	S. infantis CCUG 33221 A
147389	S. infantis CCUG 33513
148270	S. infantis CCUG 35130 A
149035	S. infantis CCUG 36756
150391	S. infantis CCUG 39818
150392	S. infantis CCUG 39819
150393	S. infantis CCUG 39820
150394	S. infantis CCUG 39821
151693	S. infantis CCUG 44654
151974	S. infantis CCUG 45411 A
151975	S. infantis CCUG 45411 B
152018	S. infantis CCUG 45564
152093	S. infantis CCUG 45729
152637	S. infantis CCUG 47249
154835	S. infantis CCUG 55362

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
125438				90
120104	positive	coccus-shaped

Colony morphology

120104

Hemolysis ability1

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
4746	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
4746	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	Medium recipe at MediaDive	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
40272	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
120104	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
4746	positive	growth	37
40272	positive	growth	37
54944	positive	growth	37
67770	positive	growth	37
120104	positive	growth	25-41
120104	negative	growth	10
120104	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
4746	microaerophile
54944	microaerophile
120104	facultative anaerobe
125439	facultative anaerobe	93.419

Spore formation

@ref	Spore formation	Confidence
125439		93.384

Halophily

@ref	Salt	Growth	Tested relation	Concentration
120104	NaCl		growth	6.5 %

Murein

@ref	Murein short key	Type
4746	A11	A1alpha L-Lys-direct

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68371	18305 ChEBI	arbutin	+	builds acid from	from API 50CH acid
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
120104	4853 ChEBI	esculin	-	hydrolysis
68371	4853 ChEBI	esculin	+	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
120104	606565 ChEBI	hippurate	-	hydrolysis
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	+	builds acid from	from API 50CH acid
120104	17632 ChEBI	nitrate	-	reduction
120104	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68381	27082 ChEBI	trehalose	-	builds acid from	from API rID32STR
68371	27082 ChEBI	trehalose	+	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	+	builds acid from	from API 50CH acid
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
68381	15688 ChEBI	acetoin	-	from API rID32STR
120104	15688 ChEBI	acetoin	-

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68381	Alanyl-Phenylalanyl-Proline arylamidase	+		from API rID32STR
120104	alcohol dehydrogenase	-	1.1.1.1
68381	alkaline phosphatase	-	3.1.3.1	from API rID32STR
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	+	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68382	beta-galactosidase	+	3.2.1.23	from API zym
120104	beta-galactosidase	-	3.2.1.23
68381	beta-glucosidase	-	3.2.1.21	from API rID32STR
68382	beta-glucosidase	-	3.2.1.21	from API zym
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
120104	catalase	-	1.11.1.6
68382	cystine arylamidase	+	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
120104	gamma-glutamyltransferase	-	2.3.2.2
68381	glycyl tryptophan arylamidase	+		from API rID32STR
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
120104	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
120104	ornithine decarboxylase	-	4.1.1.17
120104	oxidase	-
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68382	trypsin	-	3.4.21.4	from API zym
68381	urease	-	3.5.1.5	from API rID32STR
68382	valine arylamidase	+		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
120104	-	-	+	+	-	+	+	+	-	+	+	+	-	+	-	+	-	+	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
120104	not determinedn.d.	-	-	-	-	-	-	-	-	-	+	+	+	+	-	-	-	-	-	-	-	-	+	+/-	+	+	+	+/-	+	+	-	+	+	-	-	-	+/-	-	-	-	+	-	-	-	-	-	-	-	-	-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
4746	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-
4746	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	+	+	-	-	-	-	-	-	-	-	-
4746	-	-	+	-	-	-	-	-	-	+	-	-	+	-	-	-	-	+	-	-	-	+	-	-	+	+	-	-	-	-	-	-
4746	-	-	+	-	-	-	-	-	-	+	-	-	+	-	-	-	-	+	+	-	+	+	+	-	+	+	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Tooth

Isolation

@ref	Sample type	Host species	Geographic location	Country	Country ISO 3 Code	Continent	Sampling date	Isolation date
4746	human tooth surface	Homo sapiens	Japan	Japan	JPN	Asia
54944	Human pharynx,3-year-old healthy male	Homo sapiens		Japan	JPN	Asia	1990
67770	Human tooth surface	Homo sapiens
120104	Human, Pharynx	Homo sapiens		Japan	JPN	Asia		1990

Taxonmaps

69479

Global distribution of 16S sequence AY485603 (>99% sequence identity) for Streptococcus from Microbeatlas

Aquatic Samples	108
Soil Samples	30
Animal Samples	9178
Plant Samples	110
Total Samples	9426

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Biosafety level	Biosafety level comment
4746	yes, in single cases	1	Risk group (German classification) According to TRBA 466
120104		2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM18746v1 assembly for Streptococcus infantis ATCC 700779	scaffold	GCA_000187465	889204.3	649990007	889204	72.62
67770	SinfantisSK959v1.0 assembly for Streptococcus infantis ATCC 700779	contig	GCA_000260755	889204.5	2534682079	889204	68.13

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
4746	Streptococcus infantis strain ATCC 700779 16S small subunit ribosomal RNA gene, partial sequence	AY485603	1468	889204
67770	Streptococcus infantis gene for 16S rRNA, partial sequence	AB008315	1338	889204
67770	Streptococcus infantis strain CCUG 39817 16S ribosomal RNA gene, partial sequence	EU156759	1329	889204
67770	Streptococcus infantis gene for 16S ribosomal RNA, partial sequence, strain: JCM 10157	LC096227	1485	68892
124043	Streptococcus infantis strain CCUG 39817 16S-23S ribosomal RNA intergenic spacer, partial sequence.	DQ204503	248	68892

GC content

@ref	GC-content (mol%)	Method
4746	40.1	high performance liquid chromatography (HPLC)
67770	39.9-40.4	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM18746v1 assembly for Streptococcus infantis ATCC 700779
BV-BRC: 889204.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	gram_stain	BacteriaNetⓘ	variable	66.47	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	93.42	no
125439	motility	BacteriaNetⓘ	no	85.63	no
125439	spore_formation	BacteriaNetⓘ	no	93.38	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus infantis ATCC 700779
PATRIC: 889204.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	89.96	no
125438	anaerobic	anaerobicⓘ	no	91.77	yes
125438	aerobic	aerobicⓘ	no	97.86	no
125438	spore-forming	spore-formingⓘ	no	86.53	no
125438	thermophilic	thermophileⓘ	no	96.00	yes
125438	flagellated	motile2+ⓘ	no	90.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Reference-guided assembly of metagenomes with MetaCompass.	Luan T, Cepeda-Espinoza VP, Liu B, Bowen Z, Ayyangar U, Almeida M, Koren S, Treangen TJ, Porter A, Pop M.	Cell Rep Methods	10.1016/j.crmeth.2025.101186	2025
Pathogenicity	Insights into Within-Host Evolution and Dynamics of Oral and Intestinal Streptococci Unveil Niche Adaptation.	Abdelbary MMH, Hatting M, Dahlhausen A, Bott A, Conrads G.	Int J Mol Sci	10.3390/ijms252413507	2024
	Evolutionary Relationships Between Dysregulated Genes in Oral Squamous Cell Carcinoma and Oral Microbiota.	Fang Y, Yang Y, Liu C.	Front Cell Infect Microbiol	10.3389/fcimb.2022.931011	2022
Genetics	Nisin-like biosynthetic gene clusters are widely distributed across microbiomes.	Hourigan D, Field D, Murray E, Sugrue I, O'Connor PM, Hill C, Ross RP.	mBio	10.1128/mbio.01545-25	2025
	Partially hydrolyzed, whey-based infant formula with six human milk oligosaccharides, B. infantis LMG11588, and B. lactis CNCM I-3446 is safe, well tolerated, and improves gut health: a staged analysis of a randomized trial.	Picaud JC, Claris O, Gil-Campos M, De La Cueva IS, Cornette L, Alliet P, Leke A, Castanet M, Piloquet H, de Halleux V, Mitanchez D, Vandenplas Y, Maton P, Jochum F, Olbertz D, Policarpo SN, Lavalle L, Fumero C, Rodriguez-Garcia P, Moll JM, Silva-Zolezzi I, Zemrani B, Hays NP, Sprenger N, Miranda-Mallea J.	Front Nutr	10.3389/fnut.2025.1628847	2025
	Combining Bifidobacterium longum subsp. infantis and human milk oligosaccharides synergistically increases short chain fatty acid production ex vivo.	De Bruyn F, James K, Cottenet G, Dominick M, Katja J.	Commun Biol	10.1038/s42003-024-06628-1	2024
	Identification of Clinically Relevant Streptococcus and Enterococcus Species Based on Biochemical Methods and 16S rRNA, sodA, tuf, rpoB, and recA Gene Sequencing.	Kosecka-Strojek M, Wolska M, Zabicka D, Sadowy E, Miedzobrodzki J.	Pathogens	10.3390/pathogens9110939	2020
	Microbiological, chemical and rheological properties of low fat set yoghurt produced with exopolysaccharide (EPS) producing Bifidobacterium strains	Prasanna PHP, Grandison AS, Charalampopoulos D.	Food Res Int	10.1016/j.foodres.2012.11.016	2013
	Evidence of immunomodulatory effects of a novel probiotic, Bifidobacterium longum bv. infantis CCUG 52486.	You J, Yaqoob P.	FEMS Immunol Med Microbiol	10.1111/j.1574-695x.2012.01014.x	2012
	Screening human intestinal Bifidobacterium strains for growth, acidification, EPS production and viscosity potential in low-fat milk	Prasanna PHP, Grandison AS, Charalampopoulos D.	Int Dairy J	10.1016/j.idairyj.2011.09.008	2012
Enzymology	Emulsifying, rheological and physicochemical properties of exopolysaccharide produced by Bifidobacterium longum subsp. infantis CCUG 52486 and Bifidobacterium infantis NCIMB 702205.	Prasanna PH, Bell A, Grandison AS, Charalampopoulos D.	Carbohydr Polym	10.1016/j.carbpol.2012.05.075	2012
	Effect of dairy-based protein sources and temperature on growth, acidification and exopolysaccharide production of Bifidobacterium strains in skim milk	Prasanna PHP, Grandison AS, Charalampopoulos D.	Food Res Int	10.1016/j.foodres.2012.01.004	2012
Phylogeny	Phylogenetic, Functional and Safety Features of 1950s B. infantis Strains.	Duboux S, Ngom-Bru C, De Bruyn F, Bogicevic B.	Microorganisms	10.3390/microorganisms10020203	2022
	Streptococcus infantis, Streptococcus mitis, and Streptococcus oralis Strains With Highly Similar cps5 Loci and Antigenic Relatedness to Serotype 5 Pneumococci.	Pimenta F, Gertz RE, Park SH, Kim E, Moura I, Milucky J, Rouphael N, Farley MM, Harrison LH, Bennett NM, Bigogo G, Feikin DR, Breiman R, Lessa FC, Whitney CG, Rajam G, Schiffer J, da Gloria Carvalho M, Beall B.	Front Microbiol	10.3389/fmicb.2018.03199	2018
Transcriptome	Gene expression of bacterial collagenolytic proteases in root caries.	Dame-Teixeira N, Parolo CCF, Maltz M, Rup AG, Devine DA, Do T.	J Oral Microbiol	10.1080/20002297.2018.1424475	2018
	Minocycline resistance in an oral Streptococcus infantis isolate is encoded by tet(S) on a novel small, low copy number plasmid.	Ciric L, Brouwer MS, Mullany P, Roberts AP.	FEMS Microbiol Lett	10.1111/1574-6968.12410	2014
	Cell factory for gamma-aminobutyric acid (GABA) production using Bifidobacterium adolescentis.	Altaib H, Kozakai T, Badr Y, Nakao H, El-Nouby MAM, Yanase E, Nomura I, Suzuki T.	Microb Cell Fact	10.1186/s12934-021-01729-6	2022
	Probing oral microbial functionality--expression of spxB in plaque samples.	Zhu L, Xu Y, Ferretti JJ, Kreth J.	PLoS One	10.1371/journal.pone.0086685	2014
	Two mechanisms of oral malodor inhibition by zinc ions.	Suzuki N, Nakano Y, Watanabe T, Yoneda M, Hirofuji T, Hanioka T.	J Appl Oral Sci	10.1590/1678-7757-2017-0161	2018
	The Role and Regulatory Network of the CiaRH Two-Component System in Streptococcal Species.	He LY, Le YJ, Guo Z, Li S, Yang XY.	Front Microbiol	10.3389/fmicb.2021.693858	2021
	Exopolysaccharide Produced by Pediococcus pentosaceus E8: Structure, Bio-Activities, and Its Potential Application.	Jiang G, He J, Gan L, Li X, Xu Z, Yang L, Li R, Tian Y.	Front Microbiol	10.3389/fmicb.2022.923522	2022
	Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides.	Ojima MN, Jiang L, Arzamasov AA, Yoshida K, Odamaki T, Xiao J, Nakajima A, Kitaoka M, Hirose J, Urashima T, Katoh T, Gotoh A, van Sinderen D, Rodionov DA, Osterman AL, Sakanaka M, Katayama T.	ISME J	10.1038/s41396-022-01270-3	2022
Pathogenicity	Identification of Anion Channels Responsible for Fluoride Resistance in Oral Streptococci.	Men X, Shibata Y, Takeshita T, Yamashita Y.	PLoS One	10.1371/journal.pone.0165900	2016
Enzymology	Characterization of a purified beta-fructofuranosidase from Bifidobacterium infantis ATCC 15697.	Warchol M, Perrin S, Grill JP, Schneider F.	Lett Appl Microbiol	10.1046/j.1472-765x.2002.01224.x	2002
Pathogenicity	Rice Defensin OsAFP1 is a New Drug Candidate against Human Pathogenic Fungi.	Ochiai A, Ogawa K, Fukuda M, Ohori M, Kanaoka T, Tanaka T, Taniguchi M, Sagehashi Y.	Sci Rep	10.1038/s41598-018-29715-w	2018
	In vitro Probiotic Potential and Safety Evaluation (Hemolytic, Cytotoxic Activity) of Bifidobacterium Strains Isolated from Raw Camel Milk.	Yasmin I, Saeed M, Khan WA, Khaliq A, Chughtai MFJ, Iqbal R, Tehseen S, Naz S, Liaqat A, Mehmood T, Ahsan S, Tanweer S.	Microorganisms	10.3390/microorganisms8030354	2020
Metabolism	Gut bacteria identified in colorectal cancer patients promote tumourigenesis via butyrate secretion.	Okumura S, Konishi Y, Narukawa M, Sugiura Y, Yoshimoto S, Arai Y, Sato S, Yoshida Y, Tsuji S, Uemura K, Wakita M, Matsudaira T, Matsumoto T, Kawamoto S, Takahashi A, Itatani Y, Miki H, Takamatsu M, Obama K, Takeuchi K, Suematsu M, Ohtani N, Fukunaga Y, Ueno M, Sakai Y, Nagayama S, Hara E.	Nat Commun	10.1038/s41467-021-25965-x	2021
Phylogeny	recA-based PCR assay for accurate differentiation of Streptococcus pneumoniae from other viridans streptococci.	Zbinden A, Kohler N, Bloemberg GV.	J Clin Microbiol	10.1128/jcm.01450-10	2011
Metabolism	A Novel Actin Binding Drug with In Vivo Efficacy.	Ravichandran A, Geng M, Hull KG, Li J, Romo D, Lu SE, Albee A, Nutter C, Gordon DM, Ghannoum MA, Lockless SW, Smith L.	Antimicrob Agents Chemother	10.1128/aac.01585-18	2019
	Recent Development of Probiotic Bifidobacteria for Treating Human Diseases.	Chen J, Chen X, Ho CL.	Front Bioeng Biotechnol	10.3389/fbioe.2021.770248	2021
Metabolism	Age-Related Changes in the Natural Killer Cell Response to Seasonal Influenza Vaccination Are Not Influenced by a Synbiotic: a Randomised Controlled Trial.	Przemska-Kosicka A, Childs CE, Maidens C, Dong H, Todd S, Gosney MA, Tuohy KM, Yaqoob P.	Front Immunol	10.3389/fimmu.2018.00591	2018
	Effect of S-PRG Eluate on Biofilm Formation and Enzyme Activity of Oral Bacteria.	Yoneda M, Suzuki N, Masuo Y, Fujimoto A, Iha K, Yamada K, Iwamoto T, Hirofuji T.	Int J Dent	10.1155/2012/814913	2012
	Novel antimicrobial activities of a peptide derived from a Japanese soybean fermented food, Natto, against Streptococcus pneumoniae and Bacillus subtilis group strains.	Kitagawa M, Shiraishi T, Yamamoto S, Kutomi R, Ohkoshi Y, Sato T, Wakui H, Itoh H, Miyamoto A, Yokota SI.	AMB Express	10.1186/s13568-017-0430-1	2017
Pathogenicity	Insights into physiological and genetic mupirocin susceptibility in bifidobacteria.	Serafini F, Bottacini F, Viappiani A, Baruffini E, Turroni F, Foroni E, Lodi T, van Sinderen D, Ventura M.	Appl Environ Microbiol	10.1128/aem.02540-10	2011
	Bactericidal action of photogenerated singlet oxygen from photosensitizers used in plaque disclosing agents.	Ishiyama K, Nakamura K, Ikai H, Kanno T, Kohno M, Sasaki K, Niwano Y.	PLoS One	10.1371/journal.pone.0037871	2012
Genetics	Phylogenomic and MALDI-TOF MS analysis of Streptococcus sinensis HKU4T reveals a distinct phylogenetic clade in the genus Streptococcus.	Teng JL, Huang Y, Tse H, Chen JH, Tang Y, Lau SK, Woo PC.	Genome Biol Evol	10.1093/gbe/evu232	2014
	Surface properties of dental zirconia ceramics affected by ultrasonic scaling and low-temperature degradation.	Nakazawa K, Nakamura K, Harada A, Shirato M, Inagaki R, Ortengren U, Kanno T, Niwano Y, Egusa H.	PLoS One	10.1371/journal.pone.0203849	2018
Metabolism	Live and let die: Hydrogen peroxide production by the commensal flora and its role in maintaining a symbiotic microbiome.	Redanz S, Cheng X, Giacaman RA, Pfeifer CS, Merritt J, Kreth J.	Mol Oral Microbiol	10.1111/omi.12231	2018
Pathogenicity	Molecular Assay for Detection of Genetic Markers Associated with Decreased Susceptibility to Cephalosporins in Neisseria gonorrhoeae.	Peterson SW, Martin I, Demczuk W, Bharat A, Hoang L, Wylie J, Allen V, Lefebvre B, Tyrrell G, Horsman G, Haldane D, Garceau R, Wong T, Mulvey MR.	J Clin Microbiol	10.1128/jcm.00493-15	2015
Metabolism	Complementary Mechanisms for Degradation of Inulin-Type Fructans and Arabinoxylan Oligosaccharides among Bifidobacterial Strains Suggest Bacterial Cooperation.	Riviere A, Selak M, Geirnaert A, Van den Abbeele P, De Vuyst L.	Appl Environ Microbiol	10.1128/aem.02893-17	2018
Metabolism	Purification and characterisation of the extracellular cholesterol oxidase enzyme from Enterococcus hirae.	Yehia HM, Hassanein WA, Ibraheim SM.	BMC Microbiol	10.1186/s12866-015-0517-2	2015
	Impact of ageing and a synbiotic on the immune response to seasonal influenza vaccination; a randomised controlled trial.	Enani S, Przemska-Kosicka A, Childs CE, Maidens C, Dong H, Conterno L, Tuohy K, Todd S, Gosney M, Yaqoob P.	Clin Nutr	10.1016/j.clnu.2017.01.011	2018
	Streptococcus thermophilus ST28 ameliorates colitis in mice partially by suppression of inflammatory Th17 cells.	Ogita T, Nakashima M, Morita H, Saito Y, Suzuki T, Tanabe S.	J Biomed Biotechnol	10.1155/2011/378417	2011
	Effect of a synbiotic on the response to seasonal influenza vaccination is strongly influenced by degree of immunosenescence.	Przemska-Kosicka A, Childs CE, Enani S, Maidens C, Dong H, Dayel IB, Tuohy K, Todd S, Gosney MA, Yaqoob P.	Immun Ageing	10.1186/s12979-016-0061-4	2016
	Probiotic modulation of dendritic cell function is influenced by ageing.	You J, Dong H, Mann ER, Knight SC, Yaqoob P.	Immunobiology	10.1016/j.imbio.2013.08.012	2014
	The principal fucosylated oligosaccharides of human milk exhibit prebiotic properties on cultured infant microbiota.	Yu ZT, Chen C, Kling DE, Liu B, McCoy JM, Merighi M, Heidtman M, Newburg DS.	Glycobiology	10.1093/glycob/cws138	2013
Metabolism	The ability of bifidobacteria to degrade arabinoxylan oligosaccharide constituents and derived oligosaccharides is strain dependent.	Riviere A, Moens F, Selak M, Maes D, Weckx S, De Vuyst L.	Appl Environ Microbiol	10.1128/aem.02853-13	2014
Genetics	Pangenome analysis of Bifidobacterium longum and site-directed mutagenesis through by-pass of restriction-modification systems.	O'Callaghan A, Bottacini F, O'Connell Motherway M, van Sinderen D.	BMC Genomics	10.1186/s12864-015-1968-4	2015
Pathogenicity	Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects.	Martinez I, Kim J, Duffy PR, Schlegel VL, Walter J.	PLoS One	10.1371/journal.pone.0015046	2010
Metabolism	Broad conservation of milk utilization genes in Bifidobacterium longum subsp. infantis as revealed by comparative genomic hybridization.	LoCascio RG, Desai P, Sela DA, Weimer B, Mills DA.	Appl Environ Microbiol	10.1128/aem.00675-10	2010
Enzymology	Detection of human intestinal catalase-negative, Gram-positive cocci by rRNA-targeted reverse transcription-PCR.	Kubota H, Tsuji H, Matsuda K, Kurakawa T, Asahara T, Nomoto K.	Appl Environ Microbiol	10.1128/aem.03132-09	2010
Metabolism	Kinetic analysis of bifidobacterial metabolism reveals a minor role for succinic acid in the regeneration of NAD+ through its growth-associated production.	Van der Meulen R, Adriany T, Verbrugghe K, De Vuyst L.	Appl Environ Microbiol	10.1128/aem.00146-06	2006
	Streptococcus taonis sp. nov., a novel bacterial species isolated from a blood culture of a patient.	Lee CY, Chan CK, Chida M, Miyashita M, Lee YS, Wu HC, Chang YC, Lin WT, Chen YS.	Arch Microbiol	10.1007/s00203-024-03884-x	2024
	Identification and characterisation of carbapenem-resistant Streptococcus nidrosiense sp. nov. isolated from blood culture.	Ronning TG, Olaisen C, As CG, Afset JE, Haugan MS.	New Microbes New Infect	10.1016/j.nmni.2024.101473	2024
Phylogeny	Streptococcus peroris sp. nov. and Streptococcus infantis sp. nov., new members of the Streptococcus mitis group, isolated from human clinical specimens.	Kawamura Y, Hou XG, Todome Y, Sultana F, Hirose K, Shu SE, Ezaki T, Ohkuni H	Int J Syst Bacteriol	10.1099/00207713-48-3-921	1998
Phylogeny	Noncontiguous finished genome sequence and description of Streptococcus timonensis sp. nov. isolated from the human stomach.	Ricaboni D, Mailhe M, Lagier JC, Michelle C, Armstrong N, Bittar F, Vitton V, Benezech A, Raoult D, Million M	New Microbes New Infect	10.1016/j.nmni.2016.11.013	2016

References

#4746	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 12492
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#40272	; Curators of the CIP;
#54944	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 39817
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68381	Automatically annotated from API rID32STR .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120104	Collection of Institut Pasteur ; Curators of the CIP; CIP 105949
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus infantis (DSM 12492, ATCC 700779, JCM 10157)

Name and taxonomic classification

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