Streptococcus macacae (CCUG 27653, DSM 20724, ATCC 35911)

Name: Streptococcus macacae (CCUG 27653, DSM 20724, ATCC 35911)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 14733

Type strain

Strain Designation 25-1

Culture col. no. CCUG 27653 DSM 20724 ATCC 35911 NCTC 11558 25-1 1 more

NCBI tax ID(s) 764298 1339

Special Collections DSMZ CCUG CIP

History DSMZ <- NCTC <- D. Beighton, 25-1 CIP <- 1987, NCTC <- D. Beighton, Royal Coll. Surg., Orpington, UK: strain 25-1

Links

Streptococcus macacae 25-1 is a microaerophile, Gram-positive, rod-shaped bacterium that was isolated from dental plaque of monkey.

Gram-positive rod-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 8037

LMG 15097,ATCC 35911,CCRC 14748,CCUG 27653,CIP 102912,DSM 20724,NCTC 11558,KCTC 3659,BCRC 14748,CNCTC 6697

@ref 20215

Last LPSN update 2026-05-29 08:28:21

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Lactobacillales

Family Streptococcaceae

Genus Streptococcus

Species Streptococcus macacae

Full scientific name Streptococcus macacae Beighton et al. 1984

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
125438			91
125438	positive		92.552
120729	positive	rod-shaped

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
9034	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
9034	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	Medium recipe at MediaDive	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water
40478	MEDIUM 38 - for Streptococcus and Gemella Haemolysans		Distilled water make up to (1000.000 ml);Horse serum (200.000 ml);Glucose (10.000 g);Brain heart infusion agar (52.000 g)
120729	CIP Medium 38	Medium recipe at CIP
120729	CIP Medium 253	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
9034	positive	growth	37
40478	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
9034	microaerophile
120729	facultative anaerobe
125439	obligate aerobe	93.913

Spore formation

@ref	Spore formation	Confidence
125438		90.811
125439		93.401

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68381	40585 ChEBI	alpha-cyclodextrin	-	builds acid from	from API rID32STR
68381	29016 ChEBI	arginine	-	hydrolysis	from API rID32STR
68371	17057 ChEBI	cellobiose	+	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68381	18333 ChEBI	D-arabitol	-	builds acid from	from API rID32STR
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68381	16899 ChEBI	D-mannitol	-	builds acid from	from API rID32STR
68371	16899 ChEBI	D-mannitol	+	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	+	builds acid from	from API 50CH acid
68381	16988 ChEBI	D-ribose	-	builds acid from	from API rID32STR
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68381	16443 ChEBI	D-tagatose	-	builds acid from	from API rID32STR
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68381	28087 ChEBI	glycogen	-	builds acid from	from API rID32STR
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68381	606565 ChEBI	hippurate	-	hydrolysis	from API rID32STR
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68381	30849 ChEBI	L-arabinose	-	builds acid from	from API rID32STR
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68381	17716 ChEBI	lactose	-	builds acid from	from API rID32STR
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68381	17306 ChEBI	maltose	+	builds acid from	from API rID32STR
68371	17306 ChEBI	maltose	+	builds acid from	from API 50CH acid
68381	6731 ChEBI	melezitose	-	builds acid from	from API rID32STR
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68381	28053 ChEBI	melibiose	-	builds acid from	from API rID32STR
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68381	320055 ChEBI	methyl beta-D-glucopyranoside	-	builds acid from	from API rID32STR
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
120729	17632 ChEBI	nitrate	-	reduction
120729	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68381	27941 ChEBI	pullulan	-	builds acid from	from API rID32STR
68381	16634 ChEBI	raffinose	-	builds acid from	from API rID32STR
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	+	builds acid from	from API 50CH acid
68381	30911 ChEBI	sorbitol	-	builds acid from	from API rID32STR
68381	17992 ChEBI	sucrose	+	builds acid from	from API rID32STR
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68381	27082 ChEBI	trehalose	+	builds acid from	from API rID32STR
68371	27082 ChEBI	trehalose	+	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68381	16199 ChEBI	urea	-	hydrolysis	from API rID32STR
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68381	15688 ChEBI	acetoin		from API rID32STR
120729	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test
68381	15688 ChEBI	acetoin	+	from API rID32STR

Enzymes

@ref	Value	Activity	Ec
68381	Alanyl-Phenylalanyl-Proline arylamidase	-		from API rID32STR
68381	alkaline phosphatase	-	3.1.3.1	from API rID32STR
68381	alpha-galactosidase	-	3.2.1.22	from API rID32STR
68381	arginine dihydrolase	-	3.5.3.6	from API rID32STR
68381	beta-galactosidase	-	3.2.1.23	from API rID32STR
68381	beta-glucosidase	+	3.2.1.21	from API rID32STR
68381	beta-glucuronidase	-	3.2.1.31	from API rID32STR
68381	beta-mannosidase	-	3.2.1.25	from API rID32STR
120729	catalase	-	1.11.1.6
68381	glycyl tryptophan arylamidase	-		from API rID32STR
68381	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32STR
120729	oxidase	-
68381	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32STR
68381	urease	-	3.5.1.5	from API rID32STR
120729	urease	-	3.5.1.5

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
120729	not determinedn.d.	-	-	-	-	-	-	-	-	-	+	+	-	+	-	-	-	-	+	+/-	-	-	-	+/-	+/-	+/-	+	+	+	-	-	+	+	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	+/-

API rID32STR

@ref	ADH (Arg)	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	TAG	beta MAN	URE
9034	-	+	-	-	-	-	-	-	-	-	+	-	+	-	-	-	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Primates
#Host Body-Site	#Oral cavity and airways	#Plaque
#Host Body-Site	#Oral cavity and airways	#Tooth

Isolation

@ref	Sample type
9034	dental plaque of monkey
48872	Monkey dental plaque
120729	Animal, Monkey: Macaca fascicularis, dental plaque

Taxonmaps

69479

Global distribution of 16S sequence AJ420199 (>99% sequence identity) for Streptococcus macacae subclade from Microbeatlas

Aquatic Samples	98
Soil Samples	62
Animal Samples	1470
Plant Samples	20
Total Samples	1650

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
9034	1	Risk group (German classification) According to TRBA 466
120729	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	44738_A02 assembly for Streptococcus macacae NCTC 11558	contig	GCA_900459485	764298.7	2917313891	764298	77.41
66792	ASM18799v3 assembly for Streptococcus macacae NCTC 11558	contig	GCA_000187995	764298.3	2512047074	764298	77.14

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Streptococcus macacae strain ATCC 35911 16S ribosomal RNA gene, complete sequence	AY188351	1547	764298
20218	Streptococcus macacae partial 16S rRNA gene, strain NCTC11558	AJ420199	1435	764298
20218	S.macacae 16S rRNA	X58302	1332	764298

GC content

9034

GC-content (mol%)36.0

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: 44738_A02 assembly for Streptococcus macacae NCTC 11558
BV-BRC: 764298.7

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	93.91	no
125439	gram_stain	BacteriaNetⓘ	positive	69.99	no
125439	spore_formation	BacteriaNetⓘ	no	93.40	no
125439	motility	BacteriaNetⓘ	no	77.51	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Streptococcus macacae NCTC 11558
PATRIC: 764298.7

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	92.55	no
125438	anaerobic	anaerobicⓘ	no	87.24	no
125438	aerobic	aerobicⓘ	no	95.75	yes
125438	spore-forming	spore-formingⓘ	no	90.81	no
125438	thermophilic	thermophileⓘ	no	95.94	yes
125438	flagellated	motile2+ⓘ	no	91.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Enzymology	Phylogenetic analysis of glucosyltransferases and implications for the coevolution of mutans streptococci with their mammalian hosts.	Argimon S, Alekseyenko AV, DeSalle R, Caufield PW.	PLoS One	10.1371/journal.pone.0056305	2013
Enzymology	Comparison of culture media and chairside assays for enumerating mutans streptococci.	Hildebrandt GH, Bretz WA.	J Appl Microbiol	10.1111/j.1365-2672.2006.02877.x	2006
Metabolism	A Cas9 with PAM recognition for adenine dinucleotides.	Chatterjee P, Lee J, Nip L, Koseki SRT, Tysinger E, Sontheimer EJ, Jacobson JM, Jakimo N.	Nat Commun	10.1038/s41467-020-16117-8	2020
	Sequence analysis and plasmid mobilization of a 6.6-kb kanamycin resistance plasmid, pSNC3-Kan, from a Salmonella enterica serotype Newport isolate.	Chen CY, Nguyen LT, Strobaugh TP.	PLoS One	10.1371/journal.pone.0268502	2022
	Repurposing the Streptococcus mutans CRISPR-Cas9 System to Understand Essential Gene Function.	Shields RC, Walker AR, Maricic N, Chakraborty B, Underhill SAM, Burne RA.	PLoS Pathog	10.1371/journal.ppat.1008344	2020
	Antimicrobial Resistance Determinants Circulating among Thermophilic Campylobacter Isolates Recovered from Broilers in Ireland Over a One-Year Period.	Lynch CT, Lynch H, Burke S, Hawkins K, Buttimer C, Mc Carthy C, Egan J, Whyte P, Bolton D, Coffey A, Lucey B.	Antibiotics (Basel)	10.3390/antibiotics9060308	2020
	Fluorescent nanosensors reveal dynamic pH gradients during biofilm formation.	Hollmann B, Perkins M, Chauhan VM, Aylott JW, Hardie KR.	NPJ Biofilms Microbiomes	10.1038/s41522-021-00221-8	2021
	A multiomic approach to defining the essential genome of the globally important pathogen Corynebacterium diphtheriae.	Goodall ECA, Azevedo Antunes C, Moller J, Sangal V, Torres VVL, Gray J, Cunningham AF, Hoskisson PA, Burkovski A, Henderson IR.	PLoS Genet	10.1371/journal.pgen.1010737	2023
Genetics	Population Genetics and Characterization of Campylobacter jejuni Isolates from Western Jackdaws and Game Birds in Finland.	Kovanen S, Rossi M, Pohja-Mykra M, Nieminen T, Raunio-Saarnisto M, Sauvala M, Fredriksson-Ahomaa M, Hanninen ML, Kivisto R.	Appl Environ Microbiol	10.1128/aem.02365-18	2019
Genetics	Whole genome analysis of Leptospira licerasiae provides insight into leptospiral evolution and pathogenicity.	Ricaldi JN, Fouts DE, Selengut JD, Harkins DM, Patra KP, Moreno A, Lehmann JS, Purushe J, Sanka R, Torres M, Webster NJ, Vinetz JM, Matthias MA.	PLoS Negl Trop Dis	10.1371/journal.pntd.0001853	2012
	PIPS: pathogenicity island prediction software.	Soares SC, Abreu VA, Ramos RT, Cerdeira L, Silva A, Baumbach J, Trost E, Tauch A, Hirata R, Mattos-Guaraldi AL, Miyoshi A, Azevedo V.	PLoS One	10.1371/journal.pone.0030848	2012
	Functional divergence in shrimp anti-lipopolysaccharide factors (ALFs): from recognition of cell wall components to antimicrobial activity.	Rosa RD, Vergnes A, de Lorgeril J, Goncalves P, Perazzolo LM, Saune L, Romestand B, Fievet J, Gueguen Y, Bachere E, Destoumieux-Garzon D.	PLoS One	10.1371/journal.pone.0067937	2013
Enzymology	Biofilm formation and adherence characteristics of an Elizabethkingia meningoseptica isolate from Oreochromis mossambicus.	Jacobs A, Chenia HY.	Ann Clin Microbiol Antimicrob	10.1186/1476-0711-10-16	2011
Enzymology	Enumeration and diversity of campylobacters and bacteriophages isolated during the rearing cycles of free-range and organic chickens.	El-Shibiny A, Connerton PL, Connerton IF.	Appl Environ Microbiol	10.1128/aem.71.3.1259-1266.2005	2005
	Two separate quorum-sensing systems upregulate transcription of the same ABC transporter in Streptococcus pneumoniae.	Knutsen E, Ween O, Havarstein LS.	J Bacteriol	10.1128/jb.186.10.3078-3085.2004	2004
	Fatty acid fingerprints of Streptococcus mutans NCTC 10832 grown at various temperatures.	Drucker DB, Veazey FJ.	Appl Environ Microbiol	10.1128/aem.33.2.221-226.1977	1977
Phylogeny	Comparison of phenotypic characteristics, DNA-DNA hybridization results, and results with a commercial rapid biochemical and enzymatic reaction system for identification of viridans group streptococci.	Kikuchi K, Enari T, Totsuka K, Shimizu K.	J Clin Microbiol	10.1128/jcm.33.5.1215-1222.1995	1995

References

#9034	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20724
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#40478	; Curators of the CIP;
#48872	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 27653
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68371	Automatically annotated from API 50CH acid .
#68381	Automatically annotated from API rID32STR .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120729	Collection of Institut Pasteur ; Curators of the CIP; CIP 102912
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Streptococcus macacae (CCUG 27653, DSM 20724, ATCC 35911)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API 50CHac

API rID32STR

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900459485

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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