Streptococcus anginosus subsp. anginosus Havill III. (R. Lancefield F68A) | Type strain | DSM 20563, ATCC 12395, ATCC 33397, NCTC 10713, CCUG 27298, LMG 14502, JCM 12993, CCUG 35776, CIP 102921, HAMBI 1525, NCFB 2496 | BacDiveID:14717

Strain identifier

BacDive ID: 14717

Type strain:

Species: Streptococcus anginosus subsp. anginosus

Strain Designation: Havill III. (R. Lancefield F68A)

Culture col. no.: DSM 20563, ATCC 12395, ATCC 33397, NCTC 10713, CCUG 27298, LMG 14502, JCM 12993, CCUG 35776, CIP 102921, HAMBI 1525, NCFB 2496

Strain history: CCUG 27298 <-- NCFB 2496 <-- NCTC 10713 <-- G. Colman <-- R. C. Lancefield F68A <-- E. A. Bliss strain Havill lll.

NCBI tax ID(s): 1328 (species)

Section

Streptococcus anginosus subsp. anginosus Havill III. is a microaerophile, mesophilic human pathogen that was isolated from human throat.

human pathogen
mesophilic
microaerophile
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	07-12-2022 (DD-MM-YYYY)
	Domain	"Bacteria"
	Phylum	*Bacillota*
	Class	*Bacilli*
	Order	*Lactobacillales*
	Family	*Streptococcaceae*
	Genus	*Streptococcus*
	Species	**Streptococcus anginosus subsp. anginosus**
	Full Scientific Name (PNU)	Streptococcus anginosus subsp. anginosus (Andrewes and Horder 1906) Jensen et al. 2013

Information on morphological and physiological properties Morphology

Type of hemolysis

beta

Multimedia content

Caption:

electron microscopic image

Intellectual property rights:

© HZI/Manfred Rohde

Caption:

electron microscopic image

Intellectual property rights:

© HZI/Manfred Rohde

Caption:

electron microscopic image

Intellectual property rights:

© HZI/Manfred Rohde

Caption:

electron microscopic image

Intellectual property rights:

© HZI/Manfred Rohde

Caption:

electron microscopic image

Intellectual property rights:

© HZI/Manfred Rohde

Information on culture and growth conditions Culture and growth conditions

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

Culture medium growth

Culture medium link

Medium recipe provided by DSMZ

Culture medium composition

expand / minimize

Culture medium

TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)

Culture medium growth

Culture medium link

Medium recipe provided by DSMZ

Culture medium composition

expand / minimize

Culture medium

MEDIUM 3 - Columbia agar

Culture medium growth

Culture medium composition

expand / minimize

	Temperatures	Kind of temperature		Temperature
[Ref.: #8913]			growth	37 °C
[Ref.: #41326]			growth	37 °C
[Ref.: #67770]			growth	37 °C

[Ref.: #8913]	Temperature range	mesophilic
[Ref.: #41326]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

Oxygen tolerance

microaerophile

[Ref.: #8913]	Murein short key	A11.05
[Ref.: #8913]	Murein types	A3alpha L-Lys-L-Ala₂

	Metabolite utilization	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68381]		alpha-cyclodextrin ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		arginine ChEBI	+	hydrolysis	* from API rID32STR
[Ref.: #68381]		D-arabitol ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		D-mannitol ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		D-ribose ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		D-tagatose ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		glycogen ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		hippurate ChEBI	-	hydrolysis	* from API rID32STR
[Ref.: #68381]		L-arabinose ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		maltose ChEBI	+	builds acid from	* from API rID32STR
[Ref.: #68381]		melezitose ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		methyl beta-D-glucopyranoside ChEBI	+	builds acid from	* from API rID32STR
[Ref.: #68381]		pullulan ChEBI	+	builds acid from	* from API rID32STR
[Ref.: #68381]		raffinose ChEBI	+	builds acid from	* from API rID32STR
[Ref.: #68381]		sorbitol ChEBI	-	builds acid from	* from API rID32STR
[Ref.: #68381]		sucrose ChEBI	+	builds acid from	* from API rID32STR
[Ref.: #68381]		trehalose ChEBI	+	builds acid from	* from API rID32STR
		Only first 10 entries are displayed. Click here to see all.

	Metabolite production	Metabolite
[Ref.: #68381]		acetoin ChEBI	* from API rID32STR

	Physiological tests	Metabolite	Voges-Proskauer-test
[Ref.: #68381]		acetoin ChEBI	+	* from API rID32STR

	Enzymes	Enzyme	Enzyme activity	EC number
[Ref.: #68381]		Alanyl-Phenylalanyl-Proline arylamidase	+		* from API rID32STR
[Ref.: #68381]		alkaline phosphatase	+	3.1.3.1	* from API rID32STR
[Ref.: #68381]		arginine dihydrolase	+	3.5.3.6	* from API rID32STR
[Ref.: #68381]		beta-galactosidase	-	3.2.1.23	* from API rID32STR
[Ref.: #68381]		beta-glucosidase	+	3.2.1.21	* from API rID32STR
[Ref.: #68381]		beta-glucuronidase	-	3.2.1.31	* from API rID32STR
[Ref.: #8913]		catalase	-	1.11.1.6
[Ref.: #8913]		cytochrome-c oxidase	-	1.9.3.1
[Ref.: #68381]		glycyl tryptophan arylamidase	-		* from API rID32STR
[Ref.: #68381]		N-acetyl-beta-glucosaminidase	-	3.2.1.52	* from API rID32STR
[Ref.: #68381]		pyrrolidonyl arylamidase	-	3.4.19.3	* from API rID32STR
		Only first 10 entries are displayed. Click here to see all.

Fatty acid profile

Metadata FA analysis

Reference

Fatty acid	Percentage	ECL
C16:0	23.7	16
C18:1 ω7c /12t/9t	22.3	17.824
C14:0	14.5	14
C16:1 ω9c	9.8	15.774
C18:2 ω6,9c/C18:0 ANTE	7.9	17.724
C16:1 ω7c	7.6	15.819
C18:1 ω9c	7.3	17.769
C16:1 ω5c	3.7	15.908
C18:0	3.2	18

API® rID32STR:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	Arginine dihydrolaseADH (Arg)	beta-Glucosidasebeta GLU	beta-Galactosidasebeta GAR	beta-Glucuronidasebeta GUR	alpha-Galactosidasealpha GAL	Alkaline PhosphatasePAL	Acid from D-riboseRIB	Acid from D-mannitolMAN	Acid from sorbitolSOR	Acid from lactoseLAC	Acid from trehaloseTRE	Acid from raffinoseRAF	Acid from sucroseSAC	Acid from L-arabinoseLARA	Acid from D-arabitolDARL	Acid from alpha-cyclodextrinCDEX	Acetoin production (Voges Proskauer test)VP	Alanyl-Phenylalanyl-Proline arylamidaseAPPA	beta-Galactosidasebeta GAL	Pyrrolidonyl arylamidasePyrA	N-Acetyl-glucosaminidasebeta NAG	Glycyl-tryptophan arylamidaseGTA	Hydrolysis of hippuric acidHIP	Acid from glycogenGLYG	Acid from pullulanPUL	Acid from maltoseMAL	Acid from melibioseMEL	Acid from melezitoseMLZ	Acidification of methyl beta-D-glucopyranosideMbeta DG	Acid from D-tagatoseTAG	beta-Mannosidasebeta MAN	Urease/urea hydrolysisURE
[Ref.: #8913]	10097	+	+	-	-	-	+	-	-	-	+	+	+	+	-	-	-	+	+	-	-	-	-	-	-	+	+	-	-	+	-	+/-	-
[Ref.: #8913]	9987	+	+	-	-	+/-	+	-	-	-	+	+	+	+	-	-	-	+	+	-	-	-	-	-	-	+	+	-	-	+	-	+/-	+
[Ref.: #8913]	9717	+	+	-	-	+	+	-	-	-	+/-	+	+	+	-	-	-	+	+	-	-	-	-	-	-	+	+	-	-	+	-	+	-
[Ref.: #8913]	9716	+	+	-	-	+/-	+	-	-	-	-	+	+	+	-	-	-	+	+	-	-	-	-	-	-	+	+	+/-	-	+	-	-	-

Information on isolation source, the sampling and environmental conditions Isolation, sampling and environmental information

[Ref.: #8913]	Sample type/isolated from	human throat

[Ref.: #67770]	Sample type/isolated from	Tissue, human (human throat)
* marker position based on {}

Isolation sources categories

#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Throat

What are isolation sources categories?

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Global distribution of 16S sequence LC258132 (>99% sequence identity) for Streptococcus from Microbeatlas

Aquatic Samples	2504
Soil Samples	1377
Animal Samples	107283
Plant Samples	731
Total Samples	111895

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #8913]	Pathogenicity (human)	yes
[Ref.: #8913]	Pathogenicity (animal)	yes
[Ref.: #8913]	Biosafety level	2	Risk group (German classification) According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #20218]	Streptococcus anginosus SK52 = DSM 20563 16S ribosomal RNA gene, partial sequence	JN787169	1404	ENA	1000570 tax ID	*
[Ref.: #20218]	Streptococcus anginosus ATCC 12395 16S rRNA gene, partial sequence	U02909	396	ENA	1000570 tax ID	*
[Ref.: #8913]	Streptococcus anginosus strain ATCC33397 16S ribosomal RNA gene, partial sequence	AF104678	1573	ENA	1000570 tax ID
[Ref.: #67770]	Streptococcus anginosus gene for 16S ribosomal RNA, partial sequence, strain: JCM 12993	LC258132	1449	ENA	1328 tax ID
[Ref.: #67770]	S.anginosus 16S rRNA	X58309	1334	ENA	1328 tax ID

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Streptococcus anginosus NCTC10713	GCA_900636475	complete	GenBank	1328 tax ID	*
[Ref.: #66792]	Streptococcus anginosus SK52 = DSM 20563 ATCC 33397	GCA_002088025	contig	GenBank	1000570 tax ID	*
[Ref.: #66792]	Streptococcus anginosus SK52 = DSM 20563 DSM 20563	GCA_000373605	scaffold	GenBank	1000570 tax ID	*
[Ref.: #66792]	Streptococcus anginosus SK52 = DSM 20563 SK52	GCA_000474055	contig	GenBank	1000570 tax ID	*
[Ref.: #66792]	Streptococcus anginosus SK52 = DSM 20563 SK52	GCA_000214555	contig	GenBank	1000570 tax ID	*
[Ref.: #66792]	Streptococcus anginosus SK52 = DSM 20563	GCA_019930105	contig	GenBank	1328 tax ID	*

[Ref.: #8913]	GC-content	36.6 mol%
[Ref.: #67770]	GC-content	38-40 mol%

Availability in culture collections External links

Culture collection no.

DSM 20563, ATCC 12395, ATCC 33397, NCTC 10713, CCUG 27298, LMG 14502, JCM 12993, CCUG 35776, CIP 102921, HAMBI 1525, NCFB 2496

Associated Passport(s) in StrainInfo

55063, 55060, 723654

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Pathogenicity	Emended descriptions and recognition of Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus as distinct species.	Whiley RA, Beighton D	Int J Syst Bacteriol	10.1099/00207713-41-1-1	1991	*
Pathogenicity	Serogrouping of oral Streptococcus intermedius.	Osano E, Tanaka T, Ozeki M, Makita I, Moriyama T	Microbiol Immunol		1990	*
Pathogenicity	[Taxonomic studies of the Streptococcus intermedius strains isolated from human oral cavities].	Fujii Y	Aichi Gakuin Daigaku Shigakkai Shi		1989	*
Phylogeny	DNA-DNA hybridization studies and phenotypic characteristics of strains within the 'Streptococcus milleri group'.	Whiley RA, Hardie JM	J Gen Microbiol	10.1099/00221287-135-10-2623	1989	*
Phylogeny	Deoxyribonucleic acid relatedness and phenotypic characteristics of oral Streptococcus milleri strains.	Taketoshi M, Yakushiji T, Inoue M	Microbios		1993	*
Phylogeny	Rapid species identification of "Streptococcus milleri" strains by line blot hybridization: identification of a distinct 16S rRNA population closely related to Streptococcus constellatus.	Jacobs JA, Schot CS, Bunschoten AE, Schouls LM	J Clin Microbiol	10.1128/JCM.34.7.1717-1721.1996	1996	*
Phylogeny	A study of small-colony, beta-haemolytic, Lancefield group C streptococci within the anginosus group: description of Streptococcus constellatus subsp. pharyngis subsp. nov., associated with the human throat and pharyngitis.	Whiley RA, Hall LM, Hardie JM, Beighton D	Int J Syst Bacteriol	10.1099/00207713-49-4-1443	1999	*
Phylogeny	The Streptococcus anginosus species comprises five 16S rRNA ribogroups with different phenotypic characteristics and clinical relevance.	Jacobs JA, Schot CS, Schouls LM	Int J Syst Evol Microbiol	10.1099/00207713-50-3-1073	2000	*
Metabolism	Antigenic characterisation of a novel Streptococcus anginosus antigen that induces nitric oxide synthesis by murine peritoneal exudate cells.	Sasaki M, Ohara-Nemoto Y, Tajika S, Kobayashi M, Yamaura C, Kimura S	J Med Microbiol	10.1099/0022-1317-50-11-952	2001	*
Enzymology	Dipeptidyl peptidase IV of Streptococcus anginosus: purification and characterization.	Fujimura S, Shibata Y, Hirai K, Ueda O	Eur J Med Res		2005	*
Pathogenicity	The efficacy of povidone-iodine products against periodontopathic bacteria.	Nakagawa T, Hosaka Y, Ishihara K, Hiraishi T, Sato S, Ogawa T, Kamoi K	Dermatology	10.1159/000089208	2006	*
Pathogenicity	Identification of beta-haemolysin-encoding genes in Streptococcus anginosus.	Asam D, Mauerer S, Walheim E, Spellerberg B	Mol Oral Microbiol	10.1111/omi.12026	2013	*
Metabolism	Aciduricity and acid tolerance mechanisms of Streptococcus anginosus.	Sasaki M, Kodama Y, Shimoyama Y, Ishikawa T, Kimura S	J Gen Appl Microbiol	10.2323/jgam.2017.11.005	2018	*
Metabolism	The fibronectin-binding protein homologue Fbp62 of Streptococcus anginosus is a potent virulence factor.	Kodama Y, Ishikawa T, Shimoyama Y, Sasaki D, Kimura S, Sasaki M	Microbiol Immunol	10.1111/1348-0421.12646	2018	*
Phylogeny	Streptococcus periodonticum sp. nov., Isolated from Human Subgingival Dental Plaque of Periodontitis Lesion.	Lim YK, Park SN, Shin JH, Chang YH, Shin Y, Paek J, Kim H, Kook JK	Curr Microbiol	10.1007/s00284-019-01695-8	2019	*
Phylogeny	Streptococcus vaginalis sp. nov., a novel bacterial species isolated from vaginal swabs of a pregnant woman with diabetes.	Chao AS, Lin CY, Chao A, Lee YS, Chang YC, Wu HC, Dai YJ, Liao WQ, Kao FC, Chen YS	Arch Microbiol	10.1007/s00203-021-02532-y	2021	*
	beta-Hemolytic Streptococcus anginosus subsp. anginosus causes streptolysin S-dependent cytotoxicity to human cell culture lines in vitro.	Tabata A, Yamada T, Ohtani H, Ohkura K, Tomoyasu T, Nagamune H	J Oral Microbiol	10.1080/20002297.2019.1609839	2019	*

References

#8913

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20563

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#41326 ; Curators of the CIP;
#48705 Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 27298

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#66793

Mukherjee et al.: GEBA: 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life. 35: 676 - 683 2017 ( DOI 10.1038/nbt.3886 , PubMed 28604660 )

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#68381

Automatically annotated from API rID32STR .

#69479

João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .

#69480

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Predictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

* These data were automatically processed and therefore are not curated

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