Gardnerella vaginalis AmMS 117 is a facultative anaerobe, Gram-negative, rod-shaped bacterium that was isolated from Human.
Gram-negative rod-shaped facultative anaerobe genome sequence Bacteria SI-ID 42321
| @ref 20215 |
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Last LPSN update
2026-05-29 08:38:32 |
| Domain Bacteria |
| Phylum Actinomycetota |
| Class Actinomycetes |
| Order Bifidobacteriales |
| Family Bifidobacteriaceae |
| Genus Gardnerella |
| Species Gardnerella vaginalis |
| Full scientific name Gardnerella vaginalis (Gardner and Dukes 1955) Greenwood and Pickett 1980 |
| Synonyms (2) |
| 34416 | Oxygen tolerancefacultative anaerobe |
| @ref | Chebi-ID | Metabolite | Utilization activity | Kind of utilization tested | |
|---|---|---|---|---|---|
| 68371 | 27613 ChEBI | amygdalin | - | builds acid from | from API 50CH acid |
| 68371 | 18305 ChEBI | arbutin | - | builds acid from | from API 50CH acid |
| 68371 | 17057 ChEBI | cellobiose | - | builds acid from | from API 50CH acid |
| 68371 | 17108 ChEBI | D-arabinose | - | builds acid from | from API 50CH acid |
| 68371 | 18333 ChEBI | D-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 15824 ChEBI | D-fructose | + | builds acid from | from API 50CH acid |
| 68371 | 28847 ChEBI | D-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 12936 ChEBI | D-galactose | + | builds acid from | from API 50CH acid |
| 68371 | 17634 ChEBI | D-glucose | + | builds acid from | from API 50CH acid |
| 68371 | 62318 ChEBI | D-lyxose | - | builds acid from | from API 50CH acid |
| 68371 | 16899 ChEBI | D-mannitol | - | builds acid from | from API 50CH acid |
| 68371 | 16024 ChEBI | D-mannose | - | builds acid from | from API 50CH acid |
| 68371 | 16988 ChEBI | D-ribose | + | builds acid from | from API 50CH acid |
| 68371 | 17924 ChEBI | D-sorbitol | - | builds acid from | from API 50CH acid |
| 68371 | 16443 ChEBI | D-tagatose | - | builds acid from | from API 50CH acid |
| 68371 | 65327 ChEBI | D-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17113 ChEBI | erythritol | - | builds acid from | from API 50CH acid |
| 34416 | 4853 ChEBI | esculin | - | hydrolysis | |
| 68371 | 4853 ChEBI | esculin | - | builds acid from | from API 50CH acid |
| 68371 | 16813 ChEBI | galactitol | - | builds acid from | from API 50CH acid |
| 68371 | 28066 ChEBI | gentiobiose | - | builds acid from | from API 50CH acid |
| 68371 | 24265 ChEBI | gluconate | + | builds acid from | from API 50CH acid |
| 68371 | 17754 ChEBI | glycerol | - | builds acid from | from API 50CH acid |
| 68371 | 28087 ChEBI | glycogen | + | builds acid from | from API 50CH acid |
| 34416 | 606565 ChEBI | hippurate | - | hydrolysis | |
| 68371 | 15443 ChEBI | inulin | - | builds acid from | from API 50CH acid |
| 68371 | 30849 ChEBI | L-arabinose | + | builds acid from | from API 50CH acid |
| 68371 | 18403 ChEBI | L-arabitol | - | builds acid from | from API 50CH acid |
| 68371 | 18287 ChEBI | L-fucose | - | builds acid from | from API 50CH acid |
| 68371 | 62345 ChEBI | L-rhamnose | - | builds acid from | from API 50CH acid |
| 68371 | 17266 ChEBI | L-sorbose | - | builds acid from | from API 50CH acid |
| 68371 | 65328 ChEBI | L-xylose | - | builds acid from | from API 50CH acid |
| 68371 | 17716 ChEBI | lactose | - | builds acid from | from API 50CH acid |
| 68371 | 17306 ChEBI | maltose | + | builds acid from | from API 50CH acid |
| 68371 | 6731 ChEBI | melezitose | - | builds acid from | from API 50CH acid |
| 68371 | 28053 ChEBI | melibiose | - | builds acid from | from API 50CH acid |
| 68371 | 320061 ChEBI | methyl alpha-D-glucopyranoside | + | builds acid from | from API 50CH acid |
| 68371 | 43943 ChEBI | methyl alpha-D-mannoside | - | builds acid from | from API 50CH acid |
| 68371 | 74863 ChEBI | methyl beta-D-xylopyranoside | - | builds acid from | from API 50CH acid |
| 68371 | 17268 ChEBI | myo-inositol | - | builds acid from | from API 50CH acid |
| 68371 | 59640 ChEBI | N-acetylglucosamine | - | builds acid from | from API 50CH acid |
| 34416 | 17632 ChEBI | nitrate | - | reduction | |
| 34416 | 17632 ChEBI | nitrate | + | respiration | |
| 34416 | 16301 ChEBI | nitrite | - | reduction | |
| 68371 | 0 ChEBI | Potassium 2-ketogluconate | - | builds acid from | from API 50CH acid |
| 68371 | 0 ChEBI | Potassium 5-ketogluconate | + | builds acid from | from API 50CH acid |
| 68371 | 16634 ChEBI | raffinose | - | builds acid from | from API 50CH acid |
| 68371 | 15963 ChEBI | ribitol | - | builds acid from | from API 50CH acid |
| 68371 | 17814 ChEBI | salicin | - | builds acid from | from API 50CH acid |
| 68371 | 28017 ChEBI | starch | + | builds acid from | from API 50CH acid |
| 68371 | 17992 ChEBI | sucrose | - | builds acid from | from API 50CH acid |
| 68371 | 32528 ChEBI | turanose | + | builds acid from | from API 50CH acid |
| 68371 | 17151 ChEBI | xylitol | - | builds acid from | from API 50CH acid |
| @ref | Metabolite | Is sensitive | Is resistant | |
|---|---|---|---|---|
| 34416 | 0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate) |
| @ref | Value | Activity | Ec | |
|---|---|---|---|---|
| 68382 | acid phosphatase | + | 3.1.3.2 | from API zym |
| 34416 | alcohol dehydrogenase | - | 1.1.1.1 | |
| 68382 | alkaline phosphatase | - | 3.1.3.1 | from API zym |
| 68382 | alpha-chymotrypsin | - | 3.4.21.1 | from API zym |
| 68382 | alpha-fucosidase | - | 3.2.1.51 | from API zym |
| 68382 | alpha-galactosidase | - | 3.2.1.22 | from API zym |
| 68382 | alpha-glucosidase | + | 3.2.1.20 | from API zym |
| 68382 | alpha-mannosidase | - | 3.2.1.24 | from API zym |
| 34416 | amylase | + | ||
| 68382 | beta-galactosidase | + | 3.2.1.23 | from API zym |
| 34416 | beta-galactosidase | + | 3.2.1.23 | |
| 68382 | beta-glucosidase | - | 3.2.1.21 | from API zym |
| 68382 | beta-glucuronidase | - | 3.2.1.31 | from API zym |
| 34416 | caseinase | - | 3.4.21.50 | |
| 34416 | catalase | - | 1.11.1.6 | |
| 68382 | cystine arylamidase | - | 3.4.11.3 | from API zym |
| 34416 | DNase | - | ||
| 68382 | esterase (C 4) | + | from API zym | |
| 68382 | esterase lipase (C 8) | + | from API zym | |
| 34416 | gamma-glutamyltransferase | - | 2.3.2.2 | |
| 34416 | gelatinase | - | ||
| 34416 | lecithinase | + | ||
| 68382 | leucine arylamidase | + | 3.4.11.1 | from API zym |
| 34416 | lipase | - | ||
| 68382 | lipase (C 14) | - | from API zym | |
| 34416 | lysine decarboxylase | - | 4.1.1.18 | |
| 68382 | N-acetyl-beta-glucosaminidase | - | 3.2.1.52 | from API zym |
| 68382 | naphthol-AS-BI-phosphohydrolase | + | from API zym | |
| 34416 | ornithine decarboxylase | - | 4.1.1.17 | |
| 34416 | oxidase | - | ||
| 34416 | protease | + | ||
| 68382 | trypsin | - | 3.4.21.4 | from API zym |
| 34416 | tryptophan deaminase | - | ||
| 34416 | tween esterase | - | ||
| 34416 | urease | - | 3.5.1.5 | |
| 68382 | valine arylamidase | - | from API zym |
| @ref | ControlQ | GLY | ERY | DARA | LARA | RIB | DXYL | LXYL | ADO | MDX | GAL | GLU | FRU | MNE | SBE | RHA | DUL | INO | MAN | SOR | MDM | MDG | NAG | AMY | ARB | ESC | SAL | CEL | MAL | LAC | MEL | SAC | TRE | INU | MLZ | RAF | AMD | GLYG | XLT | GEN | TUR | LYX | TAG | DFUC | LFUC | DARL | LARL | GNT | 2KG | 5KG | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 34416 | not determinedn.d. | - | - | - | + | + | - | - | - | - | + | + | + | - | - | - | - | - | - | - | - | + | - | - | - | - | - | - | + | - | - | - | +/- | - | - | - | + | + | - | - | + | - | - | - | - | - | - | + | - | + |
| @ref | Description | Assembly level | INSDC accession | BV-BRC accession | IMG accession | NCBI tax ID | Score | |
|---|---|---|---|---|---|---|---|---|
| 66792 | ASM191383v1 assembly for Gardnerella vaginalis ATCC 49145 | contig | GCA_001913835   | 2702.107  | 2854673377  | 2702 | 74.87 | |
| 66792 | ASM303492v1 assembly for Gardnerella vaginalis ATCC 49145 | contig | GCA_003034925 | 2702.154 | 2854671940 | 2702 | 74.61 | |
| Topic | Title | Authors | Journal | DOI | Year | |
|---|---|---|---|---|---|---|
| Transformation of Gardnerella vaginalis with a Bifidobacterium-Escherichia coli shuttle vector plasmid. | Kularatne BMDN, Hill JE. | Microbiol Spectr | 10.1128/spectrum.00481-25 | 2025 | | |
| Ceragenins Prevent the Development of Murine Vaginal Infection Caused by Gardnerella vaginalis. | Wnorowska U, Piktel E, Daniluk T, Paprocka P, Savage PB, Durnas B, Bucki R. | Pharmaceuticals (Basel) | 10.3390/ph17111445 | 2024 | | |
| Pathogenicity | Genetic transformation of Gardnerella species and characterization of vaginolysin and sialidase mutants. | Klimowicz AK, Garcia EM, Jefferson KK, Dillard JP. | Infect Immun | 10.1128/iai.00299-25 | 2025 | |
| Genetics | Isolation, identification and comparative genomic analysis of Lactobacillus salivarius from Mongolian horse vagina. | Zhao Y, Liu Y, Tao J, Cao J, Lin Y, He Q, Fang X, Yun S, Du M, Su S, Bao T, Bai D, Zhang X, Dugarjaviin M. | Front Microbiol | 10.3389/fmicb.2025.1635639 | 2025 | |
| Gardnerella fibrinogen-binding protein as a candidate adherence factor. | Bulavaite A, Dapkunas J, Reskeviciute R, Dalgediene I, Valancauskas L, Baranauskiene L, Pleckaityte M. | Front Cell Infect Microbiol | 10.3389/fcimb.2025.1556232 | 2025 | | |
| Genetics | Interpretation of vaginal metagenomic characteristics in different types of vaginitis. | Song J, Dong X, Lan Y, Lu Y, Liu X, Kang X, Huang Z, Yue B, Liu Y, Ma W, Zhang L, Yan H, He M, Fan Z, Guo T. | mSystems | 10.1128/msystems.01377-23 | 2024 | |
| Type II Restriction-Modification System from Gardnerella vaginalis ATCC 14018. | Bulavaite A, Dalgediene I, Michailoviene V, Pleckaityte M. | Pathogens | 10.3390/pathogens9090703 | 2020 | | |
| Prevotella are major contributors of sialidases in the human vaginal microbiome. | Pelayo P, Hussain FA, Werlang CA, Wu CM, Woolston BM, Xiang CM, Rutt L, France MT, Ravel J, Ribbeck K, Kwon DS, Balskus EP. | Proc Natl Acad Sci U S A | 10.1073/pnas.2400341121 | 2024 | | |
| Microdroplet co-cultivation and interaction characterization of human vaginal bacteria. | Jackman CM, Deans KW, Forney LJ, Lin XN. | Integr Biol (Camb) | 10.1093/intbio/zyz006 | 2019 | | |
| A Cationic Amphipathic Tilapia Piscidin 4 Peptide-Based Antimicrobial Formulation Promotes Eradication of Bacterial Vaginosis-Associated Bacterial Biofilms. | Lin WC, Chen YR, Chuang CM, Chen JY. | Front Microbiol | 10.3389/fmicb.2022.806654 | 2022 | | |
| Phylogeny | Complex species and strain ecology of the vaginal microbiome from pregnancy to postpartum and association with preterm birth. | Pace RM, Chu DM, Prince AL, Ma J, Seferovic MD, Aagaard KM. | Med | 10.1016/j.medj.2021.06.001 | 2021 | |
| Genetics | Assessing the Genomic Variability of Gardnerella vaginalis through Comparative Genomic Analyses: Evolutionary and Ecological Implications. | Tarracchini C, Lugli GA, Mancabelli L, Milani C, Turroni F, Ventura M. | Appl Environ Microbiol | 10.1128/aem.02188-20 | 2020 | |
| Genetics | Genome Investigation of Urinary Gardnerella Strains and Their Relationship to Isolates of the Vaginal Microbiota. | Putonti C, Thomas-White K, Crum E, Hilt EE, Price TK, Wolfe AJ. | mSphere | 10.1128/msphere.00154-21 | 2021 | |
| Testing of Anti-EMT, Anti-Inflammatory and Antibacterial Activities of 2',4'-Dimethoxychalcone. | Zhao P, Xu M, Gong K, Lu K, Ruan C, Yu X, Zhu J, Guan H, Zhu Q. | Pharmaceuticals (Basel) | 10.3390/ph17050653 | 2024 | | |
| Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens. | Ma Z, He S, Yuan Y, Zhuang Z, Liu Y, Wang H, Chen J, Xu X, Ding C, Molodtsov V, Lin W, Robertson GT, Weiss WJ, Pulse M, Nguyen P, Duncan L, Doyle T, Ebright RH, Lynch AS. | J Med Chem | 10.1021/acs.jmedchem.1c02045 | 2022 | | |
| Gardnerella Revisited: Species Heterogeneity, Virulence Factors, Mucosal Immune Responses, and Contributions to Bacterial Vaginosis. | Shvartsman E, Hill JE, Sandstrom P, MacDonald KS. | Infect Immun | 10.1128/iai.00390-22 | 2023 | | |
| Genetics | Resolution and characterization of distinct cpn60-based subgroups of Gardnerella vaginalis in the vaginal microbiota. | Paramel Jayaprakash T, Schellenberg JJ, Hill JE. | PLoS One | 10.1371/journal.pone.0043009 | 2012 | |
| Identification and characterization of NanH2 and NanH3, enzymes responsible for sialidase activity in the vaginal bacterium Gardnerella vaginalis. | Robinson LS, Schwebke J, Lewis WG, Lewis AL. | J Biol Chem | 10.1074/jbc.ra118.006221 | 2019 | | |
| Pathogenicity | Effect of biofilm phenotype on resistance of Gardnerella vaginalis to hydrogen peroxide and lactic acid. | Patterson JL, Girerd PH, Karjane NW, Jefferson KK. | Am J Obstet Gynecol | 10.1016/j.ajog.2007.02.027 | 2007 | |
| Metabolism | Bacterial modulation of human fetal membrane Toll-like receptor expression. | Abrahams VM, Potter JA, Bhat G, Peltier MR, Saade G, Menon R. | Am J Reprod Immunol | 10.1111/aji.12016 | 2013 | |
| Metabolism | Functional and phylogenetic characterization of Vaginolysin, the human-specific cytolysin from Gardnerella vaginalis. | Gelber SE, Aguilar JL, Lewis KL, Ratner AJ. | J Bacteriol | 10.1128/jb.01965-07 | 2008 | |
| Amniotic fluid and maternal race influence responsiveness of fetal membranes to bacteria. | Peltier MR, Drobek CO, Bhat G, Saade G, Fortunato SJ, Menon R. | J Reprod Immunol | 10.1016/j.jri.2012.07.006 | 2012 | | |
| Pathogenicity | Human-specific bacterial pore-forming toxins induce programmed necrosis in erythrocytes. | LaRocca TJ, Stivison EA, Hod EA, Spitalnik SL, Cowan PJ, Randis TM, Ratner AJ. | mBio | 10.1128/mbio.01251-14 | 2014 | |
| Metabolism | Activity of Genital Tract Secretions and Synthetic Antimicrobial Peptides against Group B Streptococcus. | Agarwal N, Buckley N, Nakra N, Gialanella P, Yuan W, Ghartey JP. | Am J Reprod Immunol | 10.1111/aji.12427 | 2015 | |
| Enzymology | Lactobacillus crispatus dominant vaginal microbiome is associated with inhibitory activity of female genital tract secretions against Escherichia coli. | Ghartey JP, Smith BC, Chen Z, Buckley N, Lo Y, Ratner AJ, Herold BC, Burk RD. | PLoS One | 10.1371/journal.pone.0096659 | 2014 | |
| The Cervicovaginal Microbiota-Host Interaction Modulates Chlamydia trachomatis Infection. | Edwards VL, Smith SB, McComb EJ, Tamarelle J, Ma B, Humphrys MS, Gajer P, Gwilliam K, Schaefer AM, Lai SK, Terplan M, Mark KS, Brotman RM, Forney LJ, Bavoil PM, Ravel J. | mBio | 10.1128/mbio.01548-19 | 2019 | | |
| Metabolism | Acquisition of iron by Gardnerella vaginalis. | Jarosik GP, Land CB, Duhon P, Chandler R, Mercer T. | Infect Immun | 10.1128/iai.66.10.5041-5047.1998 | 1998 | |
| Enzymology | In vitro inhibition of commercial douche products against vaginal microflora. | Pavlova SI, Tao L. | Infect Dis Obstet Gynecol | 10.1002/(sici)1098-0997(2000)8:2<99::aid-idog7>3.0.co;2-n | 2000 | |
| Genetics | Draft Genome Sequence of Gardnerella vaginalis Strain ATCC 49145 Associated with Bacterial Vaginosis. | Kidane DT, Arivett BA, Crigler J, Vick EJ, Farone AL, Farone MB | Genome Announc | 10.1128/genomeA.00286-17 | 2017 | |
| Pathogenicity | Inhibitory activity of thymol on native and mature Gardnerella vaginalis biofilms: in vitro study. | Braga PC, Dal Sasso M, Culici M, Spallino A | Arzneimittelforschung | 10.1055/s-0031-1296346 | 2010 | |
How to citeIf you want to cite this particular strain cite the following doi:
https://doi.org/10.13145/bacdive135327.20260601.11
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BacDive in 2025: the core database for prokaryotic strain data
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