Streptomyces avidinii (DSM 40526, ATCC 27419, CBS 730.72)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	9615
  multimedia content:	DSM_40526.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_40526.jpg
  caption:	Medium 65 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9615	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
19470	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19470	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19470	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19470	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19470	ISP 6			Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19470	ISP 7			Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
9615	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Halophily

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
19470	22599 ChEBI	arabinose	-
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
19470	62968 ChEBI	cellulose	-
68368	16947 ChEBI	citrate	+	assimilation	from API 20E
19470	28757 ChEBI	fructose	-
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
19470	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	+	degradation	from API 20E
19470	29864 ChEBI	mannitol	-
19470	17268 ChEBI	myo-inositol	-
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
19470	16634 ChEBI	raffinose	-
19470	26546 ChEBI	rhamnose	-
19470	17992 ChEBI	sucrose	-
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E
19470	18222 ChEBI	xylose	-

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68368	gelatinase	+		from API 20E
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	+	3.5.1.5	from API 20E

API 20E

Isolation

Taxonmaps

69479

Global distribution of 16S sequence AY999904 (>99% sequence identity) for Streptomyces from Microbeatlas

Aquatic Samples	1680
Soil Samples	19336
Animal Samples	1702
Plant Samples	3681
Total Samples	26399

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1787451v1 assembly for Streptomyces avidinii DSM 40526	contig	GCA_017874515	1895.8	2913541555	1895	70.53
66792	ASM1465069v1 assembly for Streptomyces avidinii JCM 4726	scaffold	GCA_014650695	1895.6	8113668723	1895	58.07

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Streptomyces avidinii gene for 16S rRNA, partial sequence	AB122769	564		1895
20218	Streptomyces avidinii gene for 16S ribosomal RNA, partial sequence, strain: JCM 4726	D44313	120		1895
20218	Streptomyces avidinii gene for 16S rRNA, partial sequence, strain: NBRC 13429	AB184395	1476		1895
20218	Streptomyces avidinii strain NRRL 3077 16S ribosomal RNA gene, partial sequence	AY999904	1435		1895
124043	Streptomyces avidinii strain JCM 4726 16S ribosomal RNA gene, partial sequence.	MT760600	1350		1895

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Cytosine deaminase as a negative selection marker for gene disruption and replacement in the genus Streptomyces and other actinobacteria.	Dubeau MP, Ghinet MG, Jacques PE, Clermont N, Beaulieu C, Brzezinski R.	Appl Environ Microbiol	10.1128/aem.02139-08	2009
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Enzymology	Iminobiotin affinity columns and their application to retrieval of streptavidin.	Hofmann K, Wood SW, Brinton CC, Montibeller JA, Finn FM.	Proc Natl Acad Sci U S A	10.1073/pnas.77.8.4666	1980
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Enzymology	Diversity of Cultivable Microbes From Soil of the Fildes Peninsula, Antarctica, and Their Potential Application.	Cong B, Yin X, Deng A, Shen J, Tian Y, Wang S, Yang H.	Front Microbiol	10.3389/fmicb.2020.570836	2020
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Genetics	Bacteriobiota of the Cave Church of Sts. Peter and Paul in Serbia-Culturable and Non-Culturable Communities' Assessment in the Bioconservation Potential of a Peculiar Fresco Painting.	Dimkic I, Copic M, Petrovic M, Stupar M, Savkovic Z, Knezevic A, Subakov Simic G, Ljaljevic Grbic M, Unkovic N.	Int J Mol Sci	10.3390/ijms24021016	2023
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	A Fluorescent Biosensor for Streptavidin Detection Based on Double-Hairpin DNA-Templated Copper Nanoparticles.	Xiao Q, Chen M, Nie W, Xie F, Yu X, Ma C.	Biosensors (Basel)	10.3390/bios13020168	2023
	Morphological-metabolic analysis in Streptomyces rimosus microparticle-enhanced cultivations (MPEC).	Scigaczewska A, Boruta T, Bizukojc M.	Bioprocess Biosyst Eng	10.1007/s00449-024-03015-2	2024
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	A novel multimeric sCD19-streptavidin fusion protein for functional detection and selective expansion of CD19-targeted CAR-T cells.	Lian H, Jiang J, Wang Y, Yu X, Zheng R, Long J, Zhou M, Zhou S, Wei C, Zhao A, Gao J.	Cancer Med	10.1002/cam4.4657	2022
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Metabolism	Recombinant production of human alpha2-macroglobulin variants and interaction studies with recombinant G-related alpha2-macroglobulin binding protein and latent transforming growth factor-beta2.	Marino-Puertas L, Del Amo-Maestro L, Taules M, Gomis-Ruth FX, Goulas T.	Sci Rep	10.1038/s41598-019-45712-z	2019
Metabolism	The highly dynamic oligomeric structure of bradavidin II is unique among avidin proteins.	Leppiniemi J, Meir A, Kahkonen N, Kukkurainen S, Maatta JA, Ojanen M, Janis J, Kulomaa MS, Livnah O, Hytonen VP.	Protein Sci	10.1002/pro.2281	2013
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Metabolism	Pseudomonas aeruginosa pyoverdine maturation enzyme PvdP has a noncanonical domain architecture and affords insight into a new subclass of tyrosinases.	Poppe J, Reichelt J, Blankenfeldt W.	J Biol Chem	10.1074/jbc.ra118.002560	2018
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Pathogenicity	Molecular Imaging of a New Multimodal Microbubble for Adhesion Molecule Targeting.	Ahmed M, Gustafsson B, Aldi S, Dusart P, Egri G, Butler LM, Bone D, Dahne L, Hedin U, Caidahl K.	Cell Mol Bioeng	10.1007/s12195-018-00562-z	2019
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Metabolism	Dimer-tetramer transition between solution and crystalline states of streptavidin and avidin mutants.	Pazy Y, Eisenberg-Domovich Y, Laitinen OH, Kulomaa MS, Bayer EA, Wilchek M, Livnah O.	J Bacteriol	10.1128/jb.185.14.4050-4056.2003	2003
Metabolism	Single-molecule visualization of conformational changes and substrate transport in the vitamin B12 ABC importer BtuCD-F.	Goudsmits JMH, Slotboom DJ, van Oijen AM.	Nat Commun	10.1038/s41467-017-01815-7	2017
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Pathogenicity	Expression and Regulation of Cholecystokinin Receptor in the Chicken's Immune Organs and Cells.	El-Kassas S, Odemuyiwa S, Hajishengallis G, Connell TD, Nashar TO.	J Clin Cell Immunol	10.4172/2155-9899.1000471	2016
Enzymology	An improved method for the single-step purification of streptavidin.	Bayer EA, Ben-Hur H, Gitlin G, Wilchek M.	J Biochem Biophys Methods	10.1016/0165-022x(86)90022-9	1986
Metabolism	Structures and transport dynamics of a Campylobacter jejuni multidrug efflux pump.	Su CC, Yin L, Kumar N, Dai L, Radhakrishnan A, Bolla JR, Lei HT, Chou TH, Delmar JA, Rajashankar KR, Zhang Q, Shin YK, Yu EW.	Nat Commun	10.1038/s41467-017-00217-z	2017
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Pathogenicity	Integrated hollow microneedle-optofluidic biosensor for therapeutic drug monitoring in sub-nanoliter volumes.	Ranamukhaarachchi SA, Padeste C, Dubner M, Hafeli UO, Stoeber B, Cadarso VJ.	Sci Rep	10.1038/srep29075	2016
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	Covalent decoration of adenovirus vector capsids with the carbohydrate epitope alphaGal does not improve vector immunogenicity, but allows to study the in vivo fate of adenovirus immunocomplexes.	Kratzer RF, Espenlaub S, Hoffmeister A, Kron MW, Kreppel F.	PLoS One	10.1371/journal.pone.0176852	2017
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Metabolism	Binding Cooperativity Matters: A GM1-Like Ganglioside-Cholera Toxin B Subunit Binding Study Using a Nanocube-Based Lipid Bilayer Array.	Worstell NC, Krishnan P, Weatherston JD, Wu HJ.	PLoS One	10.1371/journal.pone.0153265	2016
Pathogenicity	Covalent growth factor tethering to direct neural stem cell differentiation and self-organization.	Ham TR, Farrag M, Leipzig ND.	Acta Biomater	10.1016/j.actbio.2017.01.068	2017
Metabolism	Localisation of abundant and organ-specific genes expressed in Rosa hybrida leaves and flower buds by direct in situ RT-PCR.	Jedrzejuk A, Mibus H, Serek M.	ScientificWorldJournal	10.1100/2012/609597	2012
Enzymology	Immunoaffinity isolation of membrane antigens with biotinylated monoclonal antibodies and immobilized streptavidin matrices.	Updyke TV, Nicolson GL.	J Immunol Methods	10.1016/0022-1759(84)90034-6	1984
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	Layer-by-layer biofunctionalization of nanostructured porous silicon for high-sensitivity and high-selectivity label-free affinity biosensing.	Mariani S, Robbiano V, Strambini LM, Debrassi A, Egri G, Dahne L, Barillaro G.	Nat Commun	10.1038/s41467-018-07723-8	2018
Metabolism	Role of LRRK2 in the regulation of dopamine receptor trafficking.	Rassu M, Del Giudice MG, Sanna S, Taymans JM, Morari M, Brugnoli A, Frassineti M, Masala A, Esposito S, Galioto M, Valle C, Carri MT, Biosa A, Greggio E, Crosio C, Iaccarino C.	PLoS One	10.1371/journal.pone.0179082	2017
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Metabolism	The structure of the SBP-Tag-streptavidin complex reveals a novel helical scaffold bridging binding pockets on separate subunits.	Barrette-Ng IH, Wu SC, Tjia WM, Wong SL, Ng KK.	Acta Crystallogr D Biol Crystallogr	10.1107/s0907444913002576	2013
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Enzymology	5'-O-Methylphosphonate nucleic acids--new modified DNAs that increase the Escherichia coli RNase H cleavage rate of hybrid duplexes.	Sipova H, Springer T, Rejman D, Simak O, Petrova M, Novak P, Rosenbergova S, Pav O, Liboska R, Barvik I, Stepanek J, Rosenberg I, Homola J.	Nucleic Acids Res	10.1093/nar/gku125	2014
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Phylogeny	Shielding effect of monovalent and divalent cations on solid-phase DNA hybridization: surface plasmon resonance biosensor study.	Springer T, Sipova H, Vaisocherova H, Stepanek J, Homola J.	Nucleic Acids Res	10.1093/nar/gkq577	2010
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	Self-assembly of proteins and their nucleic acids.	Fletcher G, Mason S, Terrett J, Soloviev M.	J Nanobiotechnology	10.1186/1477-3155-1-1	2003
	Structural and functional characteristics of xenavidin, the first frog avidin from Xenopus tropicalis.	Maatta JA, Helppolainen SH, Hytonen VP, Johnson MS, Kulomaa MS, Airenne TT, Nordlund HR.	BMC Struct Biol	10.1186/1472-6807-9-63	2009
	Improved bone morphogenetic protein-2 retention in an injectable collagen matrix using bifunctional peptides.	Hamilton PT, Jansen MS, Ganesan S, Benson RE, Hyde-Deruyscher R, Beyer WF, Gile JC, Nair SA, Hodges JA, Gron H.	PLoS One	10.1371/journal.pone.0070715	2013
	Streptavidin binding and endothelial cell adhesion to biotinylated fibronectin.	Anamelechi CC, Clermont EE, Brown MA, Truskey GA, Reichert WM.	Langmuir	10.1021/la702322n	2007
Metabolism	Secretion of streptavidin from Bacillus subtilis.	Nagarajan V, Ramaley R, Albertson H, Chen M.	Appl Environ Microbiol	10.1128/aem.59.11.3894-3898.1993	1993
	Rapid development of new protein biosensors utilizing peptides obtained via phage display.	Wu J, Park JP, Dooley K, Cropek DM, West AC, Banta S.	PLoS One	10.1371/journal.pone.0024948	2011
	Intratumoral INF-gamma triggers an antiviral state in GL261 tumor cells: a major hurdle to overcome for oncolytic vaccinia virus therapy of cancer.	Kober C, Weibel S, Rohn S, Kirscher L, Szalay AA.	Mol Ther Oncolytics	10.1038/mto.2015.9	2015
Metabolism	Plasma Exosome Profiling of Cancer Patients by a Next Generation Systems Biology Approach.	Domenyuk V, Zhong Z, Stark A, Xiao N, O'Neill HA, Wei X, Wang J, Tinder TT, Tonapi S, Duncan J, Hornung T, Hunter A, Miglarese MR, Schorr J, Halbert DD, Quackenbush J, Poste G, Berry DA, Mayer G, Famulok M, Spetzler D.	Sci Rep	10.1038/srep42741	2017
Metabolism	Transtactin: a universal transmembrane delivery system for Strep-tag II-fused cargos.	Moosmeier MA, Bulkescher J, Reed J, Schnolzer M, Heid H, Hoppe-Seyler K, Hoppe-Seyler F.	J Cell Mol Med	10.1111/j.1582-4934.2009.00846.x	2010
Metabolism	How the biotin-streptavidin interaction was made even stronger: investigation via crystallography and a chimaeric tetramer.	Chivers CE, Koner AL, Lowe ED, Howarth M.	Biochem J	10.1042/bj20101593	2011
Enzymology	Proteomic analysis of the androgen receptor via MS-compatible purification of biotinylated protein on streptavidin resin.	Austin RJ, Smidansky HM, Holstein CA, Chang DK, Epp A, Josephson NC, Martin DB.	Proteomics	10.1002/pmic.201100348	2012
	Aptamer-nanoparticle strip biosensor for sensitive detection of cancer cells.	Liu G, Mao X, Phillips JA, Xu H, Tan W, Zeng L.	Anal Chem	10.1021/ac901889s	2009
	Pretargeted radioimmunotherapy using genetically engineered antibody-streptavidin fusion proteins for treatment of non-hodgkin lymphoma.	Park SI, Shenoi J, Frayo SM, Hamlin DK, Lin Y, Wilbur DS, Stayton PS, Orgun N, Hylarides M, Buchegger F, Kenoyer AL, Axtman A, Gopal AK, Green DJ, Pagel JM, Press OW.	Clin Cancer Res	10.1158/1078-0432.ccr-11-1204	2011
	Sensitive plasma protein analysis by microparticle-based proximity ligation assays.	Darmanis S, Nong RY, Hammond M, Gu J, Alderborn A, Vanelid J, Siegbahn A, Gustafsdottir S, Ericsson O, Landegren U, Kamali-Moghaddam M.	Mol Cell Proteomics	10.1074/mcp.m900248-mcp200	2010
Metabolism	Force measurements of TCR/pMHC recognition at T cell surface.	Puech PH, Nevoltris D, Robert P, Limozin L, Boyer C, Bongrand P.	PLoS One	10.1371/journal.pone.0022344	2011
	Structural adaptation of a thermostable biotin-binding protein in a psychrophilic environment.	Meir A, Bayer EA, Livnah O.	J Biol Chem	10.1074/jbc.m112.357186	2012
Metabolism	Construction of chimeric dual-chain avidin by tandem fusion of the related avidins.	Riihimaki TA, Kukkurainen S, Varjonen S, Horha J, Nyholm TK, Kulomaa MS, Hytonen VP.	PLoS One	10.1371/journal.pone.0020535	2011
Pathogenicity	Identification of Piperazinylbenzenesulfonamides as New Inhibitors of Claudin-1 Trafficking and Hepatitis C Virus Entry.	Riva L, Song OR, Prentoe J, Helle F, L'homme L, Gattolliat CH, Vandeputte A, Feneant L, Belouzard S, Baumert TF, Asselah T, Bukh J, Brodin P, Cocquerel L, Rouille Y, Dubuisson J.	J Virol	10.1128/jvi.01982-17	2018
	Chimeric Avidin--NMR structure and dynamics of a 56 kDa homotetrameric thermostable protein.	Tossavainen H, Kukkurainen S, Maatta JA, Kahkonen N, Pihlajamaa T, Hytonen VP, Kulomaa MS, Permi P.	PLoS One	10.1371/journal.pone.0100564	2014
	A novel chimeric avidin with increased thermal stability using DNA shuffling.	Taskinen B, Airenne TT, Janis J, Rahikainen R, Johnson MS, Kulomaa MS, Hytonen VP.	PLoS One	10.1371/journal.pone.0092058	2014
Metabolism	Biotinylation is a natural, albeit rare, modification of human histones.	Kuroishi T, Rios-Avila L, Pestinger V, Wijeratne SS, Zempleni J.	Mol Genet Metab	10.1016/j.ymgme.2011.08.030	2011
	Electric field-induced direct delivery of proteins by a nanofountain probe.	Loh OY, Ho AM, Rim JE, Kohli P, Patankar NA, Espinosa HD.	Proc Natl Acad Sci U S A	10.1073/pnas.0806651105	2008
	Streptavidin crystals as nanostructured supports and image-calibration references for cryo-EM data collection.	Wang L, Ounjai P, Sigworth FJ.	J Struct Biol	10.1016/j.jsb.2008.07.008	2008
	Oval cell numbers in human chronic liver diseases are directly related to disease severity.	Lowes KN, Brennan BA, Yeoh GC, Olynyk JK.	Am J Pathol	10.1016/s0002-9440(10)65299-6	1999
	Composite RNA aptamers as functional mimics of proteins.	Xu D, Shi H.	Nucleic Acids Res	10.1093/nar/gkp243	2009
	Magnetic resonance imaging assays for dimethyl sulfoxide effect on cancer vasculature.	Cyran CC, Sennino B, Chaopathomkul B, Fu Y, Rogut V, Shames DM, Wendland MF, McDonald DM, Brasch RC.	Invest Radiol	10.1097/rli.0b013e318164b71d	2008
	Comparison of a tetravalent single-chain antibody-streptavidin fusion protein and an antibody-streptavidin chemical conjugate for pretargeted anti-CD20 radioimmunotherapy of B-cell lymphomas.	Pagel JM, Lin Y, Hedin N, Pantelias A, Axworthy D, Stone D, Hamlin DK, Wilbur DS, Press OW.	Blood	10.1182/blood-2005-11-4327	2006
Enzymology	RNA affinity tags for purification of RNAs and ribonucleoprotein complexes.	Srisawat C, Engelke DR.	Methods	10.1016/s1046-2023(02)00018-x	2002
	A novel immunotherapy for superficial bladder cancer by intravesical immobilization of GM-CSF.	Hu Z, Tan W, Zhang L, Liang Z, Xu C, Su H, Lu J, Gao J.	J Cell Mol Med	10.1111/j.1582-4934.2009.00818.x	2010
	Infrared characterization of biotinylated silicon oxide surfaces, surface stability, and specific attachment of streptavidin.	Lapin NA, Chabal YJ.	J Phys Chem B	10.1021/jp809096m	2009
	Pretarget radiotherapy with an anti-CD25 antibody-streptavidin fusion protein was effective in therapy of leukemia/lymphoma xenografts.	Zhang M, Zhang Z, Garmestani K, Schultz J, Axworthy DB, Goldman CK, Brechbiel MW, Carrasquillo JA, Waldmann TA.	Proc Natl Acad Sci U S A	10.1073/pnas.0437788100	2003
	Synthesis and characterization of polymer nanocarriers for the targeted delivery of therapeutic enzymes.	Simone E, Dziubla T, Shuvaev V, Muzykantov VR.	Methods Mol Biol	10.1007/978-1-60327-029-8_9	2010
Enzymology	Postsecretory modifications of streptavidin.	Bayer EA, Ben-Hur H, Hiller Y, Wilchek M.	Biochem J	10.1042/bj2590369	1989
Metabolism	Direct visualization of ligand-protein interactions using atomic force microscopy.	Neish CS, Martin IL, Henderson RM, Edwardson JM.	Br J Pharmacol	10.1038/sj.bjp.0704660	2002
Metabolism	A gel-based dual antibody capture and detection method for assaying of extracellular cytokine secretion: EliCell.	Spencer LA, Melo RC, Perez SA, Weller PF.	Methods Mol Biol	10.1385/1-59259-903-6:297	2005
Metabolism	Conventional and pretargeted radioimmunotherapy using bismuth-213 to target and treat non-Hodgkin lymphomas expressing CD20: a preclinical model toward optimal consolidation therapy to eradicate minimal residual disease.	Park SI, Shenoi J, Pagel JM, Hamlin DK, Wilbur DS, Orgun N, Kenoyer AL, Frayo S, Axtman A, Back T, Lin Y, Fisher DR, Gopal AK, Green DJ, Press OW.	Blood	10.1182/blood-2010-05-282327	2010
Metabolism	Induction of tolerance to cardiac allografts using donor splenocytes engineered to display on their surface an exogenous fas ligand protein.	Yolcu ES, Gu X, Lacelle C, Zhao H, Bandura-Morgan L, Askenasy N, Shirwan H.	J Immunol	10.4049/jimmunol.181.2.931	2008
Genetics	Zebavidin--an avidin-like protein from zebrafish.	Taskinen B, Zmurko J, Ojanen M, Kukkurainen S, Parthiban M, Maatta JA, Leppiniemi J, Janis J, Parikka M, Turpeinen H, Ramet M, Pesu M, Johnson MS, Kulomaa MS, Airenne TT, Hytonen VP.	PLoS One	10.1371/journal.pone.0077207	2013
	Induction of viral and tumour specific CTL responses using antibody targeted HLA class I peptide complexes.	Savage P, Cowburn P, Clayton A, Man S, McMichael A, Lemoine N, Epenetos A, Ogg G.	Br J Cancer	10.1038/sj.bjc.6600223	2002
Metabolism	Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases.	Jazurek M, Ciesiolka A, Starega-Roslan J, Bilinska K, Krzyzosiak WJ.	Nucleic Acids Res	10.1093/nar/gkw803	2016
	Efficient production of active chicken avidin using a bacterial signal peptide in Escherichia coli.	Hytonen VP, Laitinen OH, Airenne TT, Kidron H, Meltola NJ, Porkka EJ, Horha J, Paldanius T, Maatta JA, Nordlund HR, Johnson MS, Salminen TA, Airenne KJ, Yla-Herttuala S, Kulomaa MS.	Biochem J	10.1042/bj20041114	2004
Metabolism	Factors modulating the delivery and effect of enzymatic cargo conjugated with antibodies targeted to the pulmonary endothelium.	Shuvaev VV, Christofidou-Solomidou M, Scherpereel A, Simone E, Arguiri E, Tliba S, Pick J, Kennel S, Albelda SM, Muzykantov VR.	J Control Release	10.1016/j.jconrel.2006.12.025	2007
Enzymology	Internalization of novel non-viral vector TAT-streptavidin into human cells.	Rinne J, Albarran B, Jylhava J, Ihalainen TO, Kankaanpaa P, Hytonen VP, Stayton PS, Kulomaa MS, Vihinen-Ranta M.	BMC Biotechnol	10.1186/1472-6750-7-1	2007
	Engineering filamentous phage carriers to improve focusing of antibody responses against peptides.	van Houten NE, Henry KA, Smith GP, Scott JK.	Vaccine	10.1016/j.vaccine.2009.12.059	2010
Metabolism	Calcium-sensitive MRI contrast agents based on superparamagnetic iron oxide nanoparticles and calmodulin.	Atanasijevic T, Shusteff M, Fam P, Jasanoff A.	Proc Natl Acad Sci U S A	10.1073/pnas.0606749103	2006
Enzymology	SnAvi--a new tandem tag for high-affinity protein-complex purification.	Schaffer U, Schlosser A, Muller KM, Schafer A, Katava N, Baumeister R, Schulze E.	Nucleic Acids Res	10.1093/nar/gkp1178	2010
Metabolism	Rapid cleavage of RNA by RNase E in the absence of 5' monophosphate stimulation.	Kime L, Jourdan SS, Stead JA, Hidalgo-Sastre A, McDowall KJ.	Mol Microbiol	10.1111/j.1365-2958.2009.06935.x	2010
Metabolism	Three-dimensional electron microscopy reconstruction and cysteine-mediated crosslinking provide a model of the type III secretion system needle tip complex.	Cheung M, Shen DK, Makino F, Kato T, Roehrich AD, Martinez-Argudo I, Walker ML, Murillo I, Liu X, Pain M, Brown J, Frazer G, Mantell J, Mina P, Todd T, Sessions RB, Namba K, Blocker AJ.	Mol Microbiol	10.1111/mmi.12843	2015
Pathogenicity	The Trinity of cGAS, TLR9, and ALRs Guardians of the Cellular Galaxy Against Host-Derived Self-DNA.	Kumar V.	Front Immunol	10.3389/fimmu.2020.624597	2020
	Cleavage of recombinant proteins at poly-His sequences by Co(II) and Cu(II).	Andberg M, Jantti J, Heilimo S, Pihkala P, Paananen A, Koskinen AM, Soderlund H, Linder MB.	Protein Sci	10.1110/ps.072846407	2007
	Monolayers of derivatized poly(L-lysine)-grafted poly(ethylene glycol) on metal oxides as a class of biomolecular interfaces.	Ruiz-Taylor LA, Martin TL, Zaugg FG, Witte K, Indermuhle P, Nock S, Wagner P.	Proc Natl Acad Sci U S A	10.1073/pnas.98.3.852	2001
	Avidin related protein 2 shows unique structural and functional features among the avidin protein family.	Hytonen VP, Maatta JA, Kidron H, Halling KK, Horha J, Kulomaa T, Nyholm TK, Johnson MS, Salminen TA, Kulomaa MS, Airenne TT.	BMC Biotechnol	10.1186/1472-6750-5-28	2005
Metabolism	Structure of bradavidin-C-terminal residues act as intrinsic ligands.	Leppiniemi J, Gronroos T, Maatta JA, Johnson MS, Kulomaa MS, Hytonen VP, Airenne TT.	PLoS One	10.1371/journal.pone.0035962	2012
Metabolism	Action of CMG with strand-specific DNA blocks supports an internal unwinding mode for the eukaryotic replicative helicase.	Langston L, O'Donnell M.	Elife	10.7554/elife.23449	2017
Pathogenicity	Immunization with the SDPM1 peptide lowers amyloid plaque burden and improves cognitive function in the APPswePSEN1(A246E) transgenic mouse model of Alzheimer's disease.	Wang CM, Devries S, Camboni M, Glass M, Martin PT.	Neurobiol Dis	10.1016/j.nbd.2010.05.013	2010
	Revisiting 30 years of biofunctionalization and surface chemistry of inorganic nanoparticles for nanomedicine.	Conde J, Dias JT, Grazu V, Moros M, Baptista PV, de la Fuente JM.	Front Chem	10.3389/fchem.2014.00048	2014
	Site-specific N-glycosylation analysis: matrix-assisted laser desorption/ionization quadrupole-quadrupole time-of-flight tandem mass spectral signatures for recognition and identification of glycopeptides.	Krokhin O, Ens W, Standing KG, Wilkins J, Perreault H.	Rapid Commun Mass Spectrom	10.1002/rcm.1585	2004
	Thermal and sodium dodecylsulfate induced transitions of streptavidin.	Waner MJ, Navrotskaya I, Bain A, Oldham ED, Mascotti DP.	Biophys J	10.1529/biophysj.104.047266	2004
	IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion.	Lubberts E, Joosten LA, Chabaud M, van Den Bersselaar L, Oppers B, Coenen-De Roo CJ, Richards CD, Miossec P, van Den Berg WB.	J Clin Invest	10.1172/jci7739	2000
Genetics	Streptomyces antarcticus sp. nov., isolated from Horseshoe Island, Antarctica.	Sahin SM, Saticioglu IB, Duman M, Ay H.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006856	2025