Saccharomonospora viridis (DSM 43017, ATCC 15386, CBS 484.63)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	10677
  multimedia content:	DSM_43017.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_43017.jpg
  caption:	Medium 83 45°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	66793
  multimedia content:	EM_DSM_43017_1.jpg
  multimedia.multimedia content:	EM_DSM_43017_1.jpg
  caption:	electron microscopic image
  intellectual property rights:	© HZI/Manfred Rohde
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
10677	CZAPEK PEPTONE AGAR (DSMZ Medium 83)		Medium recipe at MediaDive	Name: CZAPEK PEPTONE AGAR (DSMZ Medium 83) Composition: Sucrose 30.0 g/l Agar 20.0 g/l Peptone 5.0 g/l NaNO3 3.0 g/l Yeast extract 2.0 g/l K2HPO4 1.0 g/l MgSO4 x 7 H2O 0.5 g/l KCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Distilled water
18736	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
18736	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
18736	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
18736	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
18736	ISP 6			Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
18736	ISP 7			Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes

Culture temp

Oxygen tolerance

Halophily

Observation

Fatty acid profile?

Metadata FA analysis
type of FA analysis	whole cell analysis
method/protocol	CCUG
@ref	44875
Fatty acid Percentage ECL C16:0 iso 46.4 15.626 C15:0 11.8 15 C17:1 ω6c 10.4 16.862 C16:0 7.8 16 C17:0 5.6 17 C17:0 iso 2.6 16.629 C12:0 ISO 1.9 11.608 C18:0 ISO 1.6 17.632 C15:0 ISO 1.6 14.621 C16:1 ISO H 1.6 15.461 C17:0 anteiso 1.4 16.722 C17:1 ω8c 1.4 16.792 C15:0 2OH 1.3 16.217 C16:1 ω7c 1.2 15.819 C15:1 ω6c 1.1 14.856 C14:0 ISO 0.9 13.618 C16:0 2OH 0.5 17.233 C10:0 ISO 0.5 9.605 Unidentified 0.5

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence Z38007 (>99% sequence identity) for Saccharomonospora viridis subclade from Microbeatlas

Aquatic Samples	1721
Soil Samples	9368
Animal Samples	4358
Plant Samples	2286
Total Samples	17733

Risk assessment

Phages

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM2386v1 assembly for Saccharomonospora viridis DSM 43017	complete	GCA_000023865	471857.5	644736404	471857	99.44

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Saccharomonospora viridis strain K73 16S-23S ribosomal RNA gene, internal transcribed spacer	U73426	144		471857
20218	Saccharomonospora viridis partial 16S rRNA	X54286	1376		471857
20218	S.viridis gene for 16S ribosomal RNA	Z38007	1490		1852

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Mannitol bioproduction from surplus grape musts and wine lees	Hijosa-Valsero M, Garita-Cambronero J, Paniagua-Garcia AI, Diez-Antolinez R.	Lebensm Wiss Technol		2021
	Metabolic engineering of Streptomyces explomaris for increased production of the reverse antibiotic nybomycin.	Shu W, Stegmuller J, Rodriguez-Estevez M, Ruckert-Reed C, Kalinowski J, Gromyko O, Rebets Y, Luzhetskyy A, Wittmann C.	Microb Cell Fact	10.1186/s12934-025-02860-4	2025
	Novel transaminases from thermophiles: from discovery to application.	Cardenas-Fernandez M, Sinclair O, Ward JM.	Microb Biotechnol	10.1111/1751-7915.13940	2022
	Integrated sequence and -omic features reveal novel small proteome of Mycobacterium tuberculosis.	Sinha PR, Balasubramanian R, Hegde SR.	Front Microbiol	10.3389/fmicb.2024.1335310	2024
	Challenging diagnosis of Mycolicibacterium cosmeticum/canariasense infection: A case report and literature review.	Grupel D, Sagi O, Nissan I, Grossman R, Yair M, Moran-Gilad J, Danino D.	J Clin Tuberc Other Mycobact Dis	10.1016/j.jctube.2023.100393	2023
	Pancreatic Cancer Resistance to Treatment: The Role of Microbiota.	Nista EC, Del Gaudio A, Del Vecchio LE, Mezza T, Pignataro G, Piccioni A, Gasbarrini A, Franceschi F, Candelli M.	Biomedicines	10.3390/biomedicines11010157	2023
Genetics	Genome mining for drug discovery: cyclic lipopeptides related to daptomycin.	Baltz RH.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab020	2021
	D-optimal design model and biosynthetic pathway for gentamicin production by Micromonospora purpureochromogenes NRRL B-16094.	Suliman M, Bishr AS, Tohamy STK, Alshahrani MY, Aboshanab KM.	BMC Microbiol	10.1186/s12866-025-04001-8	2025
	Role of fourteen XRE-DUF397 pairs from Streptomyces coelicolor as regulators of antibiotic production and differentiation. New players in a complex regulatory network.	Riascos C, Martinez-Carrasco A, Diaz M, Santamaria RI.	Front Microbiol	10.3389/fmicb.2023.1217350	2023
Phylogeny	Bacterial community profiling and identification of bacteria with lignin-degrading potential in different gut segments of African palm weevil larvae (Rhynchophorus phoenicis).	Lenka J, Gonzalez-Tortuero E, Kuba S, Ferry N.	Front Microbiol	10.3389/fmicb.2024.1401965	2024
	Genome sequencing and annotation of Amycolatopsis azurea DSM 43854(T).	Khatri I, Subramanian S, Mayilraj S.	Genom Data	10.1016/j.gdata.2013.12.003	2014
Metabolism	Efficient Degradation of 2-Mercaptobenzothiazole and Other Emerging Pollutants by Recombinant Bacterial Dye-Decolorizing Peroxidases.	Alsadik A, Athamneh K, Yousef AF, Shah I, Ashraf SS.	Biomolecules	10.3390/biom11050656	2021
Genetics	Comparative Genomics and Metabolomics Analyses of Clavulanic Acid-Producing Streptomyces Species Provides Insight Into Specialized Metabolism.	AbuSara NF, Piercey BM, Moore MA, Shaikh AA, Nothias LF, Srivastava SK, Cruz-Morales P, Dorrestein PC, Barona-Gomez F, Tahlan K.	Front Microbiol	10.3389/fmicb.2019.02550	2019
Metabolism	Simultaneous saccharification and co-fermentation of un-detoxified rice hull hydrolysate by Saccharomyces cerevisiae ICV D254 and Spathaspora arborariae NRRL Y-48658 for the production of ethanol and xylitol.	Hickert LR, de Souza-Cruz PB, Rosa CA, Ayub MA.	Bioresour Technol	10.1016/j.biortech.2013.05.123	2013
	Draft Genome Sequence of Amycolatopsis decaplanina Strain DSM 44594T.	Kaur N, Kumar S, Bala M, Raghava GP, Mayilraj S.	Genome Announc	10.1128/genomea.00138-13	2013
	Biological Activities of the Fruit Essential Oil, Fruit, and Root Extracts of Ferula drudeana Korovin, the Putative Anatolian Ecotype of the Silphion Plant.	Tosun F, Goger F, Iscan G, Kurkcuoglu M, Kuran FK, Miski M.	Plants (Basel)	10.3390/plants12040830	2023
Pathogenicity	[Enhanced nisin production by overexpression of nisin immunity gene nisI in the nisin-producing strain].	Hu H, Jiang L, Lin Y, Huan L, Zhong J.	Wei Sheng Wu Xue Bao		2010
Metabolism	Effects of pH and corn steep liquor variability on mannitol production by Lactobacillus intermedius NRRL B-3693.	Saha BC, Racine FM.	Appl Microbiol Biotechnol	10.1007/s00253-010-2552-0	2010
Metabolism	Mannitol production by lactic acid bacteria grown in supplemented carob syrup.	Carvalheiro F, Moniz P, Duarte LC, Esteves MP, Girio FM.	J Ind Microbiol Biotechnol	10.1007/s10295-010-0823-5	2011
	Control of pyrimidine nucleotide formation in Pseudomonas fulva.	West TP.	Antonie Van Leeuwenhoek	10.1007/s10482-009-9410-z	2010
Genetics	Discovery of Antimicrobial Phosphonopeptide Natural Products from Bacillus velezensis by Genome Mining.	Wilson J, Cui J, Nakao T, Kwok H, Zhang Y, Kayrouz CM, Pham TM, Roodhouse H, Ju KS.	Appl Environ Microbiol	10.1128/aem.00338-23	2023
Metabolism	Complete genome sequence of Saccharomonospora viridis type strain (P101).	Pati A, Sikorski J, Nolan M, Lapidus A, Copeland A, Glavina Del Rio T, Lucas S, Chen F, Tice H, Pitluck S, Cheng JF, Chertkov O, Brettin T, Han C, Detter JC, Kuske C, Bruce D, Goodwin L, Chain P, D'haeseleer P, Chen A, Palaniappan K, Ivanova N, Mavromatis K, Mikhailova N, Rohde M, Tindall BJ, Goker M, Bristow J, Eisen JA, Markowitz V, Hugenholtz P, Kyrpides NC, Klenk HP.	Stand Genomic Sci	10.4056/sigs.20263	2009
	Bacterial transformation of lignin: key enzymes and high-value products.	Gu J, Qiu Q, Yu Y, Sun X, Tian K, Chang M, Wang Y, Zhang F, Huo H.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02447-4	2024
	Production of mannitol by Lactobacillus intermedius NRRL B-3693 in fed-batch and continuous cell-recycle fermentations	Racine FM, Saha BC.	Process biochemistry.		2007
	Phytochemical composition and pharmacological activities of Teucrium polium L. collected from eastern Turkey.	Gulsoy Toplan G, Goger F, Taskin T, Ecevit-Genc G, Civas A, Iscan G, Kurkcuoglu M, Mat A, Baser KHC.	Turk J Chem	10.3906/kim-2107-13	2022
	Ent-homocyclopiamine B, a Prenylated Indole Alkaloid of Biogenetic Interest from the Endophytic Fungus Penicillium concentricum.	Ali T, Pham TM, Ju KS, Rakotondraibe HL.	Molecules	10.3390/molecules24020218	2019
Metabolism	Creating Oxidase-Peroxidase Fusion Enzymes as a Toolbox for Cascade Reactions.	Colpa DI, Loncar N, Schmidt M, Fraaije MW.	Chembiochem	10.1002/cbic.201700478	2017
	Characterization of a novel aromatic substrate-processing microcompartment in Actinobacteria.	Doron L, Sutter M, Kerfeld CA.	mBio	10.1128/mbio.01216-23	2023
	Production of mannitol from inulin by simultaneous enzymatic saccharification and fermentation with Lactobacillus intermedius NRRL B-3693	Saha BC.	Enzyme and Microbial Technology.		2006
	The Degradative Capabilities of New Amycolatopsis Isolates on Polylactic Acid.	Decorosi F, Exana ML, Pini F, Adessi A, Messini A, Giovannetti L, Viti C.	Microorganisms	10.3390/microorganisms7120590	2019
Pathogenicity	Effect of salt nutrients on mannitol production by Lactobacillus intermedius NRRL B-3693.	Saha BC.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0140-1	2006
Enzymology	Characterization of the amicetin biosynthesis gene cluster from Streptomyces vinaceusdrappus NRRL 2363 implicates two alternative strategies for amide bond formation.	Zhang G, Zhang H, Li S, Xiao J, Zhang G, Zhu Y, Niu S, Ju J, Zhang C.	Appl Environ Microbiol	10.1128/aem.07185-11	2012
	Method for making mannitol with Lactobacillus intermedius	Saha BC.	United States Department of Agriculture patents.		2005
Metabolism	A low-cost medium for mannitol production by Lactobacillus intermedius NRRL B-3693.	Saha BC.	Appl Microbiol Biotechnol	10.1007/s00253-006-0364-z	2006
Metabolism	Heterologous Expression of the Nybomycin Gene Cluster from the Marine Strain Streptomyces albus subsp. chlorinus NRRL B-24108.	Rodriguez Estevez M, Myronovskyi M, Gummerlich N, Nadmid S, Luzhetskyy A.	Mar Drugs	10.3390/md16110435	2018
	Comparative Studies on Essential Oil and Phenolic Content with In Vitro Antioxidant, Anticholinesterase, Antimicrobial Activities of Achillea biebersteinii Afan. and A. millefolium subsp. millefolium Afan. L. Growing in Eastern Turkey.	Toplan GG, Taskin T, Iscan G, Goger F, Kurkcuoglu M, Civas A, Ecevit-Genc G, Mat A, Baser KHC.	Molecules	10.3390/molecules27061956	2022
	Cyanuric acid hydrolase: evolutionary innovation by structural concatenation.	Peat TS, Balotra S, Wilding M, French NG, Briggs LJ, Panjikar S, Cowieson N, Newman J, Scott C.	Mol Microbiol	10.1111/mmi.12249	2013
	Complete genome sequence of Saccharothrix espanaensis DSM 44229(T) and comparison to the other completely sequenced Pseudonocardiaceae.	Strobel T, Al-Dilaimi A, Blom J, Gessner A, Kalinowski J, Luzhetska M, Puhler A, Szczepanowski R, Bechthold A, Ruckert C.	BMC Genomics	10.1186/1471-2164-13-465	2012
Metabolism	Defining sequence space and reaction products within the cyanuric acid hydrolase (AtzD)/barbiturase protein family.	Seffernick JL, Erickson JS, Cameron SM, Cho S, Dodge AG, Richman JE, Sadowsky MJ, Wackett LP.	J Bacteriol	10.1128/jb.00791-12	2012
	Classifying nitrilases as aliphatic and aromatic using machine learning technique.	Sharma N, Verma R, Savitri, Bhalla TC.	3 Biotech	10.1007/s13205-018-1102-9	2018
Metabolism	Production of mannitol and lactic acid by fermentation with Lactobacillus intermedius NRRL B-3693.	Saha BC, Nakamura LK.	Biotechnol Bioeng	10.1002/bit.10638	2003
Genetics	Unravelling the antibiotic and heavy metal resistome of a chronically polluted soil.	Salam LB.	3 Biotech	10.1007/s13205-020-02219-z	2020
	Extending Designed Linear Biocatalytic Cascades for Organic Synthesis.	Gandomkar S, Zadlo-Dobrowolska A, Kroutil W.	ChemCatChem	10.1002/cctc.201801063	2019
	Amidochelocardin Overcomes Resistance Mechanisms Exerted on Tetracyclines and Natural Chelocardin.	Hennessen F, Miethke M, Zaburannyi N, Loose M, Lukezic T, Bernecker S, Huttel S, Jansen R, Schmiedel J, Fritzenwanker M, Imirzalioglu C, Vogel J, Westermann AJ, Hesterkamp T, Stadler M, Wagenlehner F, Petkovic H, Herrmann J, Muller R.	Antibiotics (Basel)	10.3390/antibiotics9090619	2020
Metabolism	Distribution of glucan-branching enzymes among prokaryotes.	Suzuki E, Suzuki R.	Cell Mol Life Sci	10.1007/s00018-016-2243-9	2016
	Streptomyces clavuligerus: The Omics Era.	Liras P, Martin JF.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab072	2021
Metabolism	Identification and utilization of two important transporters: SgvT1 and SgvT2, for griseoviridin and viridogrisein biosynthesis in Streptomyces griseoviridis.	Xie Y, Ma J, Qin X, Li Q, Ju J.	Microb Cell Fact	10.1186/s12934-017-0792-8	2017
	Complete genome sequence of the actinomycete Actinoalloteichus hymeniacidonis type strain HPA 177T isolated from a marine sponge.	Schaffert L, Albersmeier A, Winkler A, Kalinowski J, Zotchev SB, Ruckert C.	Stand Genomic Sci	10.1186/s40793-016-0213-3	2016
	In vivo functional analysis of a class A beta-lactamase-related protein essential for clavulanic acid biosynthesis in Streptomyces clavuligerus.	Srivastava SK, King KS, AbuSara NF, Malayny CJ, Piercey BM, Wilson JA, Tahlan K.	PLoS One	10.1371/journal.pone.0215960	2019
Enzymology	Dedicated ent-kaurene and ent-atiserene synthases for platensimycin and platencin biosynthesis.	Smanski MJ, Yu Z, Casper J, Lin S, Peterson RM, Chen Y, Wendt-Pienkowski E, Rajski SR, Shen B.	Proc Natl Acad Sci U S A	10.1073/pnas.1106919108	2011
Pathogenicity	Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters.	Ahmed Y, Rebets Y, Estevez MR, Zapp J, Myronovskyi M, Luzhetskyy A.	Microb Cell Fact	10.1186/s12934-020-1277-8	2020
	Production of beta-Lactamase Inhibitors by Streptomyces Species.	Viana Marques DA, Machado SEF, Ebinuma VCS, Duarte CAL, Converti A, Porto ALF.	Antibiotics (Basel)	10.3390/antibiotics7030061	2018
Metabolism	Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.	Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K.	Appl Environ Microbiol	10.1128/aem.00693-17	2017
Metabolism	Independent evolutionary origins of functional polyamine biosynthetic enzyme fusions catalysing de novo diamine to triamine formation.	Green R, Hanfrey CC, Elliott KA, McCloskey DE, Wang X, Kanugula S, Pegg AE, Michael AJ.	Mol Microbiol	10.1111/j.1365-2958.2011.07757.x	2011
Genetics	A systematic study of the whole genome sequence of Amycolatopsis methanolica strain 239T provides an insight into its physiological and taxonomic properties which correlate with its position in the genus.	Tang B, Xie F, Zhao W, Wang J, Dai S, Zheng H, Ding X, Cen X, Liu H, Yu Y, Zhou H, Zhou Y, Zhang L, Goodfellow M, Zhao GP.	Synth Syst Biotechnol	10.1016/j.synbio.2016.05.001	2016
Metabolism	Distribution analysis of hydrogenases in surface waters of marine and freshwater environments.	Barz M, Beimgraben C, Staller T, Germer F, Opitz F, Marquardt C, Schwarz C, Gutekunst K, Vanselow KH, Schmitz R, LaRoche J, Schulz R, Appel J.	PLoS One	10.1371/journal.pone.0013846	2010
Metabolism	A mycobacterial phosphoribosyltransferase promotes bacillary survival by inhibiting oxidative stress and autophagy pathways in macrophages and zebrafish.	Mohanty S, Jagannathan L, Ganguli G, Padhi A, Roy D, Alaridah N, Saha P, Nongthomba U, Godaly G, Gopal RK, Banerjee S, Sonawane A.	J Biol Chem	10.1074/jbc.m114.598482	2015
Enzymology	PKMiner: a database for exploring type II polyketide synthases.	Kim J, Yi GS.	BMC Microbiol	10.1186/1471-2180-12-169	2012
Metabolism	Functional heterologous production of reductive dehalogenases from Desulfitobacterium hafniense strains.	Mac Nelly A, Kai M, Svatos A, Diekert G, Schubert T.	Appl Environ Microbiol	10.1128/aem.00881-14	2014
	Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.	Komatsu M, Komatsu K, Koiwai H, Yamada Y, Kozone I, Izumikawa M, Hashimoto J, Takagi M, Omura S, Shin-ya K, Cane DE, Ikeda H.	ACS Synth Biol	10.1021/sb3001003	2013
	Diversity and Functional Properties of Lactic Acid Bacteria Isolated From Wild Fruits and Flowers Present in Northern Argentina.	Ruiz Rodriguez LG, Mohamed F, Bleckwedel J, Medina R, De Vuyst L, Hebert EM, Mozzi F.	Front Microbiol	10.3389/fmicb.2019.01091	2019
Genetics	Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.	Chandra G, Chater KF.	FEMS Microbiol Rev	10.1111/1574-6976.12047	2014
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Metabolism	Biotransformation of sisomicin to gentamicin C2b.	Lee BK, Bailey JV, Condon RG, Marquez JA, Wagman GH, Weinstein MJ.	Antimicrob Agents Chemother	10.1128/aac.12.3.335	1977
Pathogenicity	Mutagenesis of Micromonospora rosaria by using protoplasts and mycelial fragments.	Kim KS, Cho NY, Pai HS, Ryu DD.	Appl Environ Microbiol	10.1128/aem.46.3.689-693.1983	1983
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Phylogeny	Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.	Gao B, Gupta RS.	Microbiol Mol Biol Rev	10.1128/mmbr.05011-11	2012
Genetics	Mining of Microbial Genomes for the Novel Sources of Nitrilases.	Sharma N, Thakur N, Raj T, Savitri, Bhalla TC.	Biomed Res Int	10.1155/2017/7039245	2017
Phylogeny	A scheme for the identification of thermophilic actinomycetes associated with hypersensitivity pneumonitis.	Kurup VP, Fink JN.	J Clin Microbiol	10.1128/jcm.2.1.55-61.1975	1975
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
Enzymology	Distribution, purification, and characterization of thermostable phenylalanine dehydrogenase from thermophilic actinomycetes.	Ohshima T, Takada H, Yoshimura T, Esaki N, Soda K.	J Bacteriol	10.1128/jb.173.13.3943-3948.1991	1991
Metabolism	A Haloalkane Dehalogenase from Saccharomonospora viridis Strain DSM 43017, a Compost Bacterium with Unusual Catalytic Residues, Unique (S)-Enantiopreference, and High Thermostability.	Chmelova K, Sebestova E, Liskova V, Beier A, Bednar D, Prokop Z, Chaloupkova R, Damborsky J	Appl Environ Microbiol	10.1128/AEM.02820-19	2020
Phenotype	Genetic variation during long-term preservation of bacteria in public culture collections.	Sakurai K, Kawasaki H	Int J Syst Evol Microbiol	10.1099/ijsem.0.002717	2018
Genetics	Genome sequencing and annotation of Amycolatopsis vancoresmycina strain DSM 44592(T).	Kaur N, Kumar S, Mayilraj S	Genom Data	10.1016/j.gdata.2013.10.006	2013
Metabolism	Application of a novel alkali-tolerant thermostable DyP-type peroxidase from Saccharomonospora viridis DSM 43017 in biobleaching of eucalyptus kraft pulp.	Yu W, Liu W, Huang H, Zheng F, Wang X, Wu Y, Li K, Xie X, Jin Y	PLoS One	10.1371/journal.pone.0110319	2014
Metabolism	Expression of the endogenous and heterologous clavulanic acid cluster in Streptomyces flavogriseus: why a silent cluster is sleeping.	Alvarez-Alvarez R, Martinez-Burgo Y, Perez-Redondo R, Brana AF, Martin JF, Liras P	Appl Microbiol Biotechnol	10.1007/s00253-013-5148-7	2013
	Amycolatopsis camponoti sp. nov., new tetracenomycin-producing actinomycete isolated from carpenter ant Camponotus vagus.	Zakalyukina YV, Osterman IA, Wolf J, Neumann-Schaal M, Nouioui I, Biryukov MV.	Antonie Van Leeuwenhoek	10.1007/s10482-022-01716-w	2022