Strain identifier
BacDive ID: 6801
Type strain: 
Species: Leptospira santarosai
Strain Designation: 1342, LT 821, Shermani
Strain history: <- R. Galloway, CDC; Shermani {2008} <- N. B. Gale
NCBI tax ID(s): 28183 (species)
version 8.1 (current version)
General
@ref: 15760
BacDive-ID: 6801
DSM-Number: 21524
keywords: genome sequence, 16S sequence, Bacteria
description: Leptospira santarosai 1342 is a bacterium that was isolated from spiney rat kidney, Proechimys semispinosus.
NCBI tax id
- NCBI tax id: 28183
- Matching level: species
strain history
- @ref: 15760
- history: <- R. Galloway, CDC; Shermani {2008} <- N. B. Gale
doi: 10.13145/bacdive6801.20230509.8.1
Name and taxonomic classification
LPSN
- @ref: 20215
- description: domain/bacteria
- keyword: phylum/spirochaetota
- domain: Bacteria
- phylum: Spirochaetota
- class: Spirochaetia
- order: Leptospirales
- family: Leptospiraceae
- genus: Leptospira
- species: Leptospira santarosai
- full scientific name: Leptospira santarosai Yasuda et al. 1987
@ref: 15760
domain: Bacteria
phylum: Spirochaetes
class: Spirochaetia
order: Spirochaetales
family: Leptospiraceae
genus: Leptospira
species: Leptospira santarosai
full scientific name: Leptospira santarosai Yasuda et al. 1987
strain designation: 1342, LT 821, Shermani
type strain: yes
Isolation, sampling and environmental information
isolation
- @ref: 15760
- sample type: spiney rat kidney, Proechimys semispinosus
- host species: Proechimys semispinosus
- country: Panama
- origin.country: PAN
- continent: Middle and South America
isolation source categories
| Cat1 | Cat2 | Cat3 |
|---|---|---|
| #Host | #Mammals | #Rodentia (Other) |
| #Host Body-Site | #Urogenital tract | #Kidney |
Safety information
risk assessment
- @ref: 15760
- biosafety level: 2
- biosafety level comment: Risk group (German classification)
Sequence information
16S sequences
- @ref: 15760
- description: Leptospira santarosai serovar Shermani strain LT 821 16S ribosomal RNA gene, partial sequence
- accession: AY631883
- length: 1431
- database: ena
- NCBI tax ID: 758847
Genome sequences
| @ref | description | accession | assembly level | database | NCBI tax ID |
|---|---|---|---|---|---|
| 66792 | Leptospira santarosai serovar Shermani str. LT 821 | GCA_000313175 | contig | ncbi | 758847 |
| 66792 | Leptospira santarosai serovar Shermani str. LT 821 | 758847.3 | wgs | patric | 758847 |
GC content
- @ref: 15760
- GC-content: 40.7
- method: high performance liquid chromatography (HPLC)
Genome-based predictions
predictions
| trait | prediction | confidence | training_data |
|---|---|---|---|
| motile | yes | 88.796 | no |
| motile | yes | 88.796 | no |
| flagellated | no | 77.109 | no |
| flagellated | no | 77.109 | no |
| gram-positive | no | 98.202 | no |
| gram-positive | no | 98.202 | no |
| anaerobic | no | 93.88 | no |
| anaerobic | no | 93.88 | no |
| aerobic | yes | 65.264 | no |
| aerobic | yes | 65.264 | no |
| halophile | no | 93.579 | no |
| halophile | no | 93.579 | no |
| spore-forming | no | 88.069 | no |
| spore-forming | no | 88.069 | no |
| thermophile | no | 84.145 | no |
| glucose-util | yes | 65.992 | no |
| glucose-util | yes | 65.992 | no |
| thermophile | no | 84.145 | no |
| glucose-ferment | no | 86.259 | no |
| glucose-ferment | no | 86.259 | no |
External links
@ref: 15760
culture collection no.: DSM 21524, ATCC 43286
straininfo link
- @ref: 76269
- straininfo: 41756
literature
| topic | Pubmed-ID | title | authors | journal | DOI | year | mesh | topic2 |
|---|---|---|---|---|---|---|---|---|
| Metabolism | 15686833 | Omp52 is a growth-phase-regulated outer membrane protein of Leptospira santarosai serovar Shermani. | Hsieh WJ, Chang YF, Chen CS, Pan MJ | FEMS Microbiol Lett | 10.1016/j.femsle.2004.12.021 | 2005 | Amino Acid Sequence, Bacterial Outer Membrane Proteins/*genetics/immunology/*metabolism, *Gene Expression Regulation, Bacterial, Humans, Immune Sera/immunology, Leptospira/genetics/*growth & development/immunology/metabolism, Leptospirosis/immunology/microbiology, Molecular Sequence Data, Recombinant Proteins/genetics/metabolism, Sequence Analysis, DNA | Pathogenicity |
| Metabolism | 16339163 | Leptospiral membrane proteins stimulate pro-inflammatory chemokines secretion by renal tubule epithelial cells through toll-like receptor 2 and p38 mitogen activated protein kinase. | Hung CC, Chang CT, Tian YC, Wu MS, Yu CC, Pan MJ, Vandewalle A, Yang CW | Nephrol Dial Transplant | 10.1093/ndt/gfi316 | 2005 | Animals, Bacterial Outer Membrane Proteins/*pharmacology, Cells, Cultured, Chemokine CCL2/genetics/metabolism, Chemokine CXCL2, Chemokines/genetics/metabolism, Cytokines/*metabolism, Enzyme-Linked Immunosorbent Assay, Epithelial Cells/drug effects/metabolism, Extracellular Signal-Regulated MAP Kinases/metabolism, Humans, JNK Mitogen-Activated Protein Kinases/metabolism, Kidney Tubules, Proximal/cytology/*drug effects/metabolism, *Leptospira, Mice, NF-kappa B/genetics/metabolism, RNA, Messenger/metabolism, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction, Toll-Like Receptor 2/genetics/*metabolism, Transfection, p38 Mitogen-Activated Protein Kinases/*metabolism | Pathogenicity |
| Pathogenicity | 16437059 | Toll-like receptor 2 mediates early inflammation by leptospiral outer membrane proteins in proximal tubule cells. | Yang CW, Hung CC, Wu MS, Tian YC, Chang CT, Pan MJ, Vandewalle A | Kidney Int | 10.1038/sj.ki.5000119 | 2006 | Animals, Antigens, Bacterial/administration & dosage, Bacterial Outer Membrane Proteins/immunology, Base Sequence, Cells, Cultured, Chemokine CCL2/metabolism, DNA/genetics, Humans, Inflammation Mediators/metabolism, Kidney Tubules, Proximal/*immunology/*parasitology, Leptospira/*immunology, Leptospirosis/immunology, Lipoproteins/immunology, Mice, Nitric Oxide Synthase Type II/metabolism, Recombinant Proteins/administration & dosage/immunology, Toll-Like Receptor 2/genetics/*metabolism, Toll-Like Receptor 4/genetics, Transfection | Metabolism |
| Pathogenicity | 16625148 | Upregulation of chemokine CXCL1/KC by leptospiral membrane lipoprotein preparation in renal tubule epithelial cells. | Hung CC, Chang CT, Chen KH, Tian YC, Wu MS, Pan MJ, Vandewalle A, Yang CW | Kidney Int | 10.1038/sj.ki.5000362 | 2006 | Animals, Bacterial Outer Membrane Proteins/immunology, Cell Line, Cells, Cultured, Chemokines, CXC/analysis/genetics/*metabolism, Dose-Response Relationship, Drug, Epithelial Cells/drug effects/immunology/metabolism, Humans, Kidney Tubules, Proximal/cytology/*immunology/*parasitology, Kinetics, Leptospira/chemistry, Lipoproteins/immunology/*pharmacology, Mice, Mice, Transgenic, RNA, Messenger/analysis, Toll-Like Receptor 2/analysis/metabolism, *Up-Regulation | Metabolism |
| Metabolism | 16928805 | Leptospiral outer membrane protein induces extracellular matrix accumulation through a TGF-beta1/Smad-dependent pathway. | Tian YC, Chen YC, Hung CC, Chang CT, Wu MS, Phillips AO, Yang CW | J Am Soc Nephrol | 10.1681/ASN.2006020159 | 2006 | Bacterial Outer Membrane Proteins/*pharmacology, Blotting, Western, Cells, Cultured, Collagen Type I/metabolism, Collagen Type IV/metabolism, Enzyme-Linked Immunosorbent Assay, Extracellular Matrix/*metabolism/microbiology, Humans, Kidney Tubules, Proximal/metabolism, Leptospira/genetics/*metabolism, Leptospirosis/blood, Reverse Transcriptase Polymerase Chain Reaction, Smad3 Protein/*metabolism, Transforming Growth Factor beta1/*metabolism | Pathogenicity |
| Pathogenicity | 17595998 | Leptospirosis in Taiwan--an underestimated infectious disease. | Yang CW | Chang Gung Med J | 3002/300202 | 2007 | Acute Kidney Injury/etiology, Adult, Aged, Female, Hemorrhage/etiology, Humans, Immunoglobulin M/blood, Leptospirosis/*complications/diagnosis/drug therapy, Lung Diseases/etiology, Male, Middle Aged, Nephritis, Interstitial/etiology, Penicillins/therapeutic use, Taiwan | |
| Pathogenicity | 18473102 | Demographic and clinical features of leptospirosis: three-year experience in central Taiwan. | Lin PC, Chi CY, Ho MW, Chen CM, Ho CM, Wang JH | J Microbiol Immunol Infect | 2008 | Adult, Demography, Female, Humans, Leptospira/isolation & purification, Leptospirosis/*diagnosis/*epidemiology/mortality/pathology, Lung/diagnostic imaging/pathology, Male, Middle Aged, Radiography, Retrospective Studies, Taiwan/epidemiology | Enzymology | |
| Genetics | 23041083 | Sequence of Leptospira santarosai serovar Shermani genome and prediction of virulence-associated genes. | Chou LF, Chen YT, Lu CW, Ko YC, Tang CY, Pan MJ, Tian YC, Chiu CH, Hung CC, Yang CW | Gene | 10.1016/j.gene.2012.09.074 | 2012 | Comparative Genomic Hybridization, *Genome, Bacterial, Leptospira/*genetics, Virulence/*genetics | |
| Metabolism | 24349474 | LipL41, a hemin binding protein from Leptospira santarosai serovar Shermani. | Lin MH, Chang YC, Hsiao CD, Huang SH, Wang MS, Ko YC, Yang CW, Sun YJ | PLoS One | 10.1371/journal.pone.0083246 | 2013 | Bacterial Proteins/genetics/*metabolism, Carrier Proteins/genetics/*metabolism, Heme-Binding Proteins, Hemeproteins/genetics/*metabolism, Hemin/genetics/*metabolism, Leptospira/genetics/*metabolism, Lipoproteins/genetics/*metabolism, Protein Multimerization/*physiology | |
| 26038504 | Potential impact on kidney infection: a whole-genome analysis of Leptospira santarosai serovar Shermani. | Chou LF, Chen TW, Ko YC, Pan MJ, Tian YC, Chiu CH, Tang P, Hung CC, Yang CW | Emerg Microbes Infect | 10.1038/emi.2014.78 | 2014 | |||
| Metabolism | 27278903 | Leptospiral outer membrane protein LipL32 induces inflammation and kidney injury in zebrafish larvae. | Chang MY, Cheng YC, Hsu SH, Ma TL, Chou LF, Hsu HH, Tian YC, Chen YC, Sun YJ, Hung CC, Pan RL, Yang CW | Sci Rep | 10.1038/srep27838 | 2016 | Animals, Bacterial Outer Membrane Proteins/genetics/*metabolism, Inflammation/embryology/genetics/microbiology, *Kidney/embryology/microbiology, *Kidney Diseases/embryology/genetics/microbiology, Leptospira/genetics/*metabolism, Lipoproteins/genetics/*metabolism, *Pronephros/embryology/microbiology, *Zebrafish/embryology/microbiology | Pathogenicity |
| Phylogeny | 28472618 | Plurality of Leptospira strains on slaughtered animals suggest a broader concept of adaptability of leptospires to cattle. | Pinto PS, Pestana C, Medeiros MA, Lilenbaum W | Acta Trop | 10.1016/j.actatropica.2017.04.032 | 2017 | Animals, Brazil/epidemiology, Cattle, Cattle Diseases/*microbiology, Female, Leptospira/*classification/*isolation & purification, Leptospirosis/epidemiology/microbiology/*veterinary, Serogroup | Enzymology |
| Pathogenicity | 29934034 | Factors associated with severity and mortality in patients with confirmed leptospirosis at a regional hospital in northern Taiwan. | Wang HK, Lee MH, Chen YC, Hsueh PR, Chang SC | J Microbiol Immunol Infect | 10.1016/j.jmii.2018.05.005 | 2018 | Acute Kidney Injury, Adult, Aged, Female, Hemorrhage/complications/epidemiology, Hospitals, Teaching, Humans, Jaundice/complications/epidemiology, Leptospira, Leptospirosis/*complications/*mortality/physiopathology, Logistic Models, Lung, Male, Meningitis/complications/epidemiology, Middle Aged, Myocarditis/complications/epidemiology, Respiratory Distress Syndrome/complications/epidemiology, Retrospective Studies, Risk Factors, *Severity of Illness Index, Shock/complications/epidemiology, Taiwan/epidemiology, Ventilators, Mechanical |
Reference
| @id | authors | catalogue | doi/url | title |
|---|---|---|---|---|
| 15760 | Curators of the DSMZ | Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 21524) | https://www.dsmz.de/collection/catalogue/details/culture/DSM-21524 | |
| 20215 | Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M. | 10.1099/ijsem.0.004332 | List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ | |
| 66792 | Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann | https://diaspora-project.de/progress.html#genomes | Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) | |
| 76269 | Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J. | 10.60712/SI-ID41756.1 | StrainInfo: A central database for resolving microbial strain identifiers |