Strain identifier

BacDive ID: 6449

Type strain: Yes

Species: Lactobacillus delbrueckii subsp. bulgaricus

Strain Designation: 14, Lb.14

Strain history: CIP <- 1984, DSMZ <- ATCC <- P.A. Hansen: strain Lb14, Lactobacillus bulgaricus <- S. Orla-Jensen: strain 14, Thermobacterium bulgaricum

NCBI tax ID(s): 390333 (strain), 1585 (subspecies)

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General

@ref: 8508

BacDive-ID: 6449

DSM-Number: 20081

keywords: genome sequence, 16S sequence, Bacteria, anaerobe, mesophilic

description: Lactobacillus delbrueckii subsp. bulgaricus 14 is an anaerobe, mesophilic bacterium that was isolated from bulgarian yoghourt.

NCBI tax id

NCBI tax idMatching level
390333strain
1585subspecies

strain history

@refhistory
8508<- ATCC <- P.A. Hansen, Lb.14 <- S. Orla-Jensen, 14 (Thermobacterium bulgaricum)
67770T. Mitsuoka S1-3 <-- ISL <-- P. A. Hansen Lb 14 <-- S. Orla-Jensen 14 ("Thermobacterium bulgaricum").
118884CIP <- 1984, DSMZ <- ATCC <- P.A. Hansen: strain Lb14, Lactobacillus bulgaricus <- S. Orla-Jensen: strain 14, Thermobacterium bulgaricum

doi: 10.13145/bacdive6449.20230509.8.1

Name and taxonomic classification

LPSN

  • @ref: 20215
  • description: domain/bacteria
  • keyword: phylum/bacillota
  • domain: Bacteria
  • phylum: Bacillota
  • class: Bacilli
  • order: Lactobacillales
  • family: Lactobacillaceae
  • genus: Lactobacillus
  • species: Lactobacillus delbrueckii subsp. bulgaricus
  • full scientific name: Lactobacillus delbrueckii subsp. bulgaricus (Orla-Jensen 1919) Weiss et al. 1984

  • synonyms

    @refsynonym
    20215Lactobacillus bulgaricus
    20215Thermobacterium bulgaricum

@ref: 8508

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Lactobacillaceae

genus: Lactobacillus

species: Lactobacillus delbrueckii subsp. bulgaricus

full scientific name: Lactobacillus delbrueckii subsp. bulgaricus (Orla-Jensen 1919) Weiss et al. 1984

strain designation: 14, Lb.14

type strain: yes

Morphology

cell morphology

@refmotilityconfidencegram staincell shape
69480no95.236
69480100positive
118884nopositiverod-shaped

colony morphology

@refincubation period
550422 days
118884

Culture and growth conditions

culture medium

@refnamegrowthlinkcomposition
8508MRS MEDIUM (DSMZ Medium 11)yeshttps://mediadive.dsmz.de/medium/11Name: MRS MEDIUM (DSMZ Medium 11) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Distilled water
41834MEDIUM 40- for Lactobacillus and LeuconostocyesDistilled water make up to (1000.000 ml);Man Rogosa Sharp agar (68.000 g)
8508MRS pre-reduced (DSMZ Medium 11b)yeshttps://mediadive.dsmz.de/medium/11bName: MRS MEDIUM (pre-reduced) (DSMZ Medium 11b) Composition: Glucose 20.0 g/l Casein peptone 10.0 g/l Meat extract 10.0 g/l Na-acetate 5.0 g/l Yeast extract 5.0 g/l (NH4)3 citrate 2.0 g/l K2HPO4 2.0 g/l Tween 80 1.0 g/l L-Cysteine HCl x H2O 0.5 g/l MgSO4 x 7 H2O 0.2 g/l MnSO4 x H2O 0.05 g/l Resazurin 0.001 g/l Distilled water
118884CIP Medium 29yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=29
118884CIP Medium 40yeshttps://catalogue-crbip.pasteur.fr/fiche_milieu.xhtml?crbip=40

culture temp

@refgrowthtypetemperaturerange
8508positivegrowth37mesophilic
41834positivegrowth37mesophilic
67770positivegrowth37mesophilic
118884positivegrowth30-45
118884nogrowth10psychrophilic
118884nogrowth15psychrophilic
118884nogrowth22psychrophilic

Physiology and metabolism

oxygen tolerance

@refoxygen tolerance
8508anaerobe
8508microaerophile
55042anaerobe
118884facultative anaerobe

spore formation

  • @ref: 69480
  • spore formation: no
  • confidence: 99.997

murein

  • @ref: 8508
  • murein short key: A11.31
  • type: A4alpha L-Lys-D-Asp

metabolite utilization

@refmetaboliteutilization activitykind of utilization testedChebi-ID
68371Potassium 5-ketogluconate-builds acid from
68371Potassium 2-ketogluconate-builds acid from
68371gluconate-builds acid from24265
68371L-arabitol-builds acid from18403
68371D-arabitol-builds acid from18333
68371L-fucose-builds acid from18287
68371D-fucose-builds acid from28847
68371D-tagatose-builds acid from16443
68371D-lyxose-builds acid from62318
68371turanose-builds acid from32528
68371gentiobiose-builds acid from28066
68371xylitol-builds acid from17151
68371glycogen-builds acid from28087
68371starch-builds acid from28017
68371raffinose-builds acid from16634
68371melezitose-builds acid from6731
68371inulin-builds acid from15443
68371trehalose-builds acid from27082
68371sucrose-builds acid from17992
68371melibiose-builds acid from28053
68371lactose+builds acid from17716
68371maltose-builds acid from17306
68371cellobiose-builds acid from17057
68371salicin-builds acid from17814
68371arbutin-builds acid from18305
68371amygdalin-builds acid from27613
68371N-acetylglucosamine-builds acid from59640
68371methyl alpha-D-glucopyranoside-builds acid from320061
68371methyl alpha-D-mannoside-builds acid from43943
68371D-sorbitol-builds acid from17924
68371D-mannitol-builds acid from16899
68371myo-inositol-builds acid from17268
68371galactitol-builds acid from16813
68371L-rhamnose-builds acid from62345
68371L-sorbose-builds acid from17266
68371D-galactose-builds acid from12936
68371methyl beta-D-xylopyranoside-builds acid from74863
68371ribitol-builds acid from15963
68371L-xylose-builds acid from65328
68371D-xylose-builds acid from65327
68371D-ribose-builds acid from16988
68371L-arabinose-builds acid from30849
68371D-arabinose-builds acid from17108
68371erythritol-builds acid from17113
68371glycerol-builds acid from17754
118884nitrate-reduction17632
118884nitrite-reduction16301
118884nitrate+respiration17632

metabolite production

  • @ref: 118884
  • Chebi-ID: 35581
  • metabolite: indole
  • production: no

metabolite tests

@refChebi-IDmetabolitevoges-proskauer-testmethylred-test
11888415688acetoin-
11888417234glucose+

enzymes

@refvalueactivityec
68382alpha-fucosidase-3.2.1.51
68382alpha-mannosidase-3.2.1.24
68382N-acetyl-beta-glucosaminidase-3.2.1.52
68382beta-glucosidase-3.2.1.21
68382alpha-glucosidase-3.2.1.20
68382beta-glucuronidase-3.2.1.31
68382beta-galactosidase+3.2.1.23
68382alpha-galactosidase-3.2.1.22
68382naphthol-AS-BI-phosphohydrolase+
68382acid phosphatase+3.1.3.2
68382alpha-chymotrypsin-3.4.21.1
68382trypsin-3.4.21.4
68382cystine arylamidase-3.4.11.3
68382valine arylamidase-
68382leucine arylamidase+3.4.11.1
68382lipase (C 14)-
68382esterase lipase (C 8)-
68382esterase (C 4)-
68382alkaline phosphatase+3.1.3.1
118884oxidase-
118884alcohol dehydrogenase-1.1.1.1
118884catalase-1.11.1.6
118884lysine decarboxylase-4.1.1.18
118884ornithine decarboxylase-4.1.1.17
118884urease-3.5.1.5

API zym

@refControlAlkaline phosphataseEsteraseEsterase LipaseLipaseLeucine arylamidaseValine arylamidaseCystine arylamidaseTrypsinalpha- ChymotrypsinAcid phosphataseNaphthol-AS-BI-phosphohydrolasealpha- Galactosidasebeta- Galactosidasebeta- Glucuronidasealpha- Glucosidasebeta- GlucosidaseN-acetyl-beta- glucosaminidasealpha- Mannosidasealpha- Fucosidase
118884-+---+----++-+------

API 50CHac

@refQGLYERYDARALARARIBDXYLLXYLADOMDXGALGLUFRUMNESBERHADULINOMANSORMDMMDGNAGAMYARBESCSALCELMALLACMELSACTREINUMLZRAFAMDGLYGXLTGENTURLYXTAGDFUCLFUCDARLLARLGNT2KG5KG
8508-----------++----------------+--------------------
8508-----------+++---------------+--------------------
8508-----------++/-----------------+--------------------
8508-----------+++---------------+--------------------
8508-----------+++---------------+--------------------
8508-----------------------------+--------------------
8508-----------+++-----------+/----+--------------------

Isolation, sampling and environmental information

isolation

@refsample type
8508bulgarian yoghourt
55042Bulgarian yogurt
67770Bulgarian yogurt
118884Food, Bulgarian yogurt

isolation source categories

  • Cat1: #Engineered
  • Cat2: #Food production
  • Cat3: #Dairy product

taxonmaps

  • @ref: 69479
  • File name: preview.99_226.png
  • url: https://microbeatlas.org/index.html?action=taxon&taxon_id=90_46;96_161;97_172;98_193;99_226&stattab=map
  • Last taxonomy: Lactobacillus delbrueckii
  • 16S sequence: KC429786
  • Sequence Identity:
  • Total samples: 60658
  • soil counts: 2030
  • aquatic counts: 6667
  • animal counts: 50988
  • plant counts: 973

Safety information

risk assessment

@refbiosafety levelbiosafety level comment
85081Risk group (German classification)
1188841Risk group (French classification)

Sequence information

16S sequences

@refdescriptionaccessionlengthdatabaseNCBI tax ID
20218Lactobacillus delbrueckii subsp. bulgaricus 16S-23S ribosomal RNA intergenic spacer region, complete sequenceAF113602220ena390333
20218Lactobacillus delbrueckii subsp. bulgaris ATCC 11842 16S ribosomal RNA gene, partial sequenceAF429503502ena390333
20218Lactobacillus delbrueckii subsp. bulgaricus strain ATCC 11842 16S ribosomal RNA gene, partial sequence; 16S-23S intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequenceAF429590536ena390333
20218Lactobacillus delbrueckii subsp. bulgaricus partial 16S rRNA gene, strain ATCC 11842AJ414693535ena390333
20218Lactobacillus delbrueckii subsp. bulgaricus 16S ribosomal RNA gene, partial sequenceAY0501711513ena390333
20218Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 16S ribosomal RNA gene, partial sequenceKC4297861423ena390333
20218L.bulgaricus rrn operon, 16S-23S rRNA spacer (long), tRNA-Ile and tRNA-Ala genesZ75475455ena390333
20218L.bulgaricus rrn operon, 16S-23S rRNA spacer (short)Z75476217ena390333
20218Lactobacillus delbrueckii subsp. bulgaricus strain BCRC10696 16S ribosomal RNA gene, complete sequenceAY7739481494ena1585
20218Lactobacillus delbrueckii subsp. bulgaricus partial 16S rRNA gene, type strain ATCC 11842TFR6831021475ena1585
20218Lactobacillus delbrueckii 16S rRNA gene from I-CeuI fragment 1, strain DSM20081AJ010835436ena1584
20218Lactobacillus delbrueckii bulgaricus (strain DSM20081) 16S rRNA gene, partialAJ010983436ena1584
20218Lactobacillus delbrueckii gene for 16S rRNA, partial sequenceAB0079081516ena1584
20218Lactobacillus delbrueckii gene, 16S-23S rRNA intergenic spacer region and 23S rRNA gene 5' flanking region, partial sequenceAB035485671ena1584
20218Lactobacillus delbrueckii subsp. bulgaricus gene for 16S rRNA, partial sequence, strain: JCM 1002AB289080675ena1585
20218Lactobacillus delbrueckii subsp. bulgaricus gene for 16S rRNA, partial sequence, strain: NBRC 13953AB6805311489ena1585
67770Lactobacillus delbrueckii subsp. bulgaricus gene for 16S ribosomal RNA, partial sequence, strain: JCM 1002LC0631621525ena1585

Genome sequences

@refdescriptionaccessionassembly leveldatabaseNCBI tax ID
66792Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002GCA_000056065completencbi390333
66792Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842390333.7completepatric390333
66792Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002390333.12wgspatric390333
66792Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002 strain DSM 20081390333.13wgspatric390333
66792Lactobacillus delbrueckii subsp. bulgaricus strain NBRC 139531585.83wgspatric1585
66792Lactobacillus delbrueckii bulgaricus JCM 10022728369678draftimg390333
66792Lactobacillus delbrueckii DSM 200812916485263draftimg1584
67770Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002GCA_001311275contigncbi390333
67770Lactobacillus delbrueckii subsp. bulgaricus NBRC 13953GCA_006539405contigncbi1585
67770Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002 DSM 20081GCA_001437195scaffoldncbi390333
66792Lactobacillus delbrueckii subsp. bulgaricus ATCC 11842 = JCM 1002 DSM 20081GCA_029823585scaffoldncbi390333

GC content

@refGC-contentmethod
850850.3
6777049.9genome sequence analysis

Genome-based predictions

predictions

traitpredictionconfidencetraining_data
spore-formingno87no
motileno95.425no
flagellatedno98.086no
gram-positiveyes94.326no
anaerobicyes56.149no
aerobicno97.429no
halophileyes84.093no
spore-formingno96.23no
thermophileno99.269yes
glucose-utilyes93.375no
glucose-fermentyes90.13no

External links

@ref: 8508

culture collection no.: DSM 20081, ATCC 11842, NCDO 1489, WDCM 00102, CCUG 41390, CIP 101027, LMG 6901, IMET 10708, JCM 1002, BCRC 10696, CCM 7190, CCUG 21450, CECT 4005, IAM 12472, IFO 13953, KCTC 3635, LMG 13551, NBRC 13953, NCFB 1489, NCIMB 11778, NCTC 12712, NRIC 1688, VKM B-1923, VTT E-96662

straininfo link

  • @ref: 75922
  • straininfo: 3281

literature

topicPubmed-IDtitleauthorsjournalDOIyearmeshtopic2
Biotechnology1368012Stability of Lactobacillus bulgaricus immobilized in kappa-carrageenan gels.Buyukgungor HJ Chem Technol Biotechnol10.1002/jctb.2805302111992Alginates, Biotechnology, Carrageenan, Fermentation, Gels, Glucuronic Acid, Hexuronic Acids, Lactobacillus/*metabolismMetabolism
Metabolism1539976Jenseniin G, a heat-stable bacteriocin produced by Propionibacterium jensenii P126.Grinstead DA, Barefoot SFAppl Environ Microbiol10.1128/aem.58.1.215-220.19921992Bacteriocins/*biosynthesis/pharmacology, Catalase/metabolism, Hot Temperature, Kinetics, Microbial Sensitivity Tests, Propionibacterium/*metabolism, TemperatureStress
Phylogeny4935327Deoxyribonucleic acid hybridization among strains of lactobacilli.Simonds J, Hansen PA, Lakshmanan SJ Bacteriol10.1128/jb.107.1.382-384.19711971Bacteriological Techniques, *DNA, Bacterial/isolation & purification, Hydroxyapatites, Lactobacillus/*classification, Phosphorus Isotopes, TemperatureEnzymology
Genetics8636057Lactobacillus bulgaricus asparagine synthetase and asparaginyl-tRNA synthetase: coregulation by transcription antitermination?Kim SI, Germond JE, Pridmore D, Soll DJ Bacteriol10.1128/jb.178.8.2459-2461.19961996Amino Acid Sequence, Amino Acyl-tRNA Synthetases/biosynthesis/*genetics, Aspartate-Ammonia Ligase/biosynthesis/*genetics, *Aspartate-tRNA Ligase, Base Sequence, *Gene Expression Regulation, Bacterial, Genes, Bacterial, Genetic Complementation Test, Lactobacillus/enzymology/*genetics, Molecular Sequence Data, Nucleic Acid Conformation, *RNA, Transfer, Amino Acyl, Sequence Homology, Amino Acid, *Terminator Regions, Genetic, *Transcription, GeneticEnzymology
Enzymology9039561Production, purification and characterization of reutericin 6, a bacteriocin with lytic activity produced by Lactobacillus reuteri LA6.Kabuki T, Saito T, Kawai Y, Uemura J, Itoh TInt J Food Microbiol10.1016/s0168-1605(96)01180-41997Amino Acids/analysis, Bacteriocins/biosynthesis/*isolation & purification/pharmacology, Lactobacillus/*metabolismBiotechnology
Metabolism11097906Physiological study of Lactobacillus delbrueckii subsp. bulgaricus strains in a novel chemically defined medium.Chervaux C, Ehrlich SD, Maguin EAppl Environ Microbiol10.1128/AEM.66.12.5306-5311.20002000Bacteriophages/growth & development, Carbohydrate Metabolism, Culture Media/*chemistry, Deoxyglucose/pharmacology, Drug Resistance, Microbial/genetics, Lactobacillus/genetics/growth & development/*physiology, Mutation, Phosphotransferases/genetics/metabolism, Polysaccharides, Bacterial/biosynthesisCultivation
Enzymology12101291Isolation of the patC gene encoding the cystathionine beta-lyase of Lactobacillus delbrueckii subsp. bulgaricus and molecular analysis of inter-strain variability in enzyme biosynthesis.Aubel D, Germond JE, Gilbert C, Atlan DMicrobiology (Reading)10.1099/00221287-148-7-20292002Amino Acid Sequence, Bacterial Proteins/*biosynthesis/chemistry/*genetics/isolation & purification, *Cloning, Molecular, Culture Media, Escherichia coli/genetics/metabolism, Kinetics, Lactobacillus/classification/*enzymology/immunology, Lyases/*biosynthesis/chemistry/*genetics/isolation & purification, Methionine/metabolism, Molecular Sequence Data, Sequence Analysis, DNAPhylogeny
Biotechnology14672834The lactobin A and amylovorin L471 encoding genes are identical, and their distribution seems to be restricted to the species Lactobacillus amylovorus that is of interest for cereal fermentations.De Vuyst L, Avonts L, Neysens P, Hoste B, Vancanneyt M, Swings J, Callewaert RInt J Food Microbiol10.1016/s0168-1605(03)00298-82004Amino Acid Sequence, Bacterial Proteins/biosynthesis/*chemistry/pharmacology, Bacteriocins/biosynthesis/*chemistry/pharmacology, Base Sequence, Edible Grain/*microbiology, Fermentation, *Food Microbiology, Hydrogen-Ion Concentration, Lactobacillus acidophilus/genetics/*metabolism, Molecular Sequence Data, Molecular Weight, Polymerase Chain Reaction/methods, Sequence Homology, Nucleic AcidGenetics
Biotechnology14678176Characterization of urease genes cluster of Streptococcus thermophilus.Mora D, Maguin E, Masiero M, Parini C, Ricci G, Manachini PL, Daffonchio DJ Appl Microbiol10.1046/j.1365-2672.2003.02148.x2004Animals, DNA, Bacterial/genetics, Food Microbiology, *Genes, Bacterial, Humans, Hydrogen-Ion Concentration, Milk/*microbiology, *Multigene Family, Mutagenesis, Site-Directed, Phenotype, Sequence Analysis, DNA/methods, Streptococcus/enzymology/*genetics/growth & development, Urease/*genetics, Yogurt/microbiologyPathogenicity
Metabolism15128544Heterologous expression of lactose- and galactose-utilizing pathways from lactic acid bacteria in Corynebacterium glutamicum for production of lysine in whey.Barrett E, Stanton C, Zelder O, Fitzgerald G, Ross RPAppl Environ Microbiol10.1128/AEM.70.5.2861-2866.20042004Bacterial Proteins/genetics/metabolism, Corynebacterium/genetics/growth & development/*metabolism, Culture Media, Galactose/*metabolism, Gene Expression Regulation, Bacterial, Genetic Engineering/methods, Lactobacillus/enzymology/genetics, Lactococcus lactis/enzymology/genetics, Lactose/*metabolism, Lysine/*metabolism, Membrane Transport Proteins/genetics/metabolism, Milk Proteins/*metabolism, *Transformation, Bacterial, Whey Proteins, beta-Galactosidase/genetics/metabolismCultivation
Genetics16300933Testing of a whole genome PCR scanning approach to identify genomic variability in four different species of lactic acid bacteria.Ben Zakour N, Grimaldi C, Gautier M, Langella P, Azevedo V, Maguin E, Le Loir YRes Microbiol10.1016/j.resmic.2005.09.0062005Bacterial Typing Techniques, Bifidobacterium/*genetics, DNA Primers, DNA, Bacterial/genetics, *Genetic Variation, *Genome, Bacterial, Lactic Acid/metabolism, Lactobacillus/*genetics, Lactobacillus plantarum/genetics, Lactococcus lactis/genetics, Polymerase Chain Reaction, SoftwareMetabolism
Metabolism16885258Production of a heterologous nonheme catalase by Lactobacillus casei: an efficient tool for removal of H2O2 and protection of Lactobacillus bulgaricus from oxidative stress in milk.Rochat T, Gratadoux JJ, Gruss A, Corthier G, Maguin E, Langella P, van de Guchte MAppl Environ Microbiol10.1128/AEM.00482-062006Animals, Catalase/*genetics/*metabolism, Culture Media, Fermentation, Food Microbiology, Gene Expression Regulation, Bacterial, Gene Expression Regulation, Enzymologic, Hydrogen Peroxide/*metabolism, Lactobacillus/*growth & development/metabolism/physiology, Lactobacillus casei/*enzymology/genetics/growth & development, Manganese/metabolism, Milk/*microbiology, *Oxidative Stress, Recombinant Proteins/genetics/metabolismBiotechnology
Metabolism19114510Postgenomic analysis of streptococcus thermophilus cocultivated in milk with Lactobacillus delbrueckii subsp. bulgaricus: involvement of nitrogen, purine, and iron metabolism.Herve-Jimenez L, Guillouard I, Guedon E, Boudebbouze S, Hols P, Monnet V, Maguin E, Rul FAppl Environ Microbiol10.1128/AEM.01984-082008Animals, Bacterial Proteins/analysis, Coculture Techniques, Gene Expression Profiling, Iron/*metabolism, Lactobacillus delbrueckii/*growth & development, Milk/*microbiology, Nitrogen/*metabolism, Proteome/analysis, Purines/*metabolism, Streptococcus thermophilus/*chemistry/*genetics/growth & developmentProteome
Enzymology19786095Exploring the acidotolerance of beta-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus: an attractive enzyme for lactose bioconversion.Rhimi M, Aghajari N, Jaouadi B, Juy M, Boudebbouze S, Maguin E, Haser R, Bejar SRes Microbiol10.1016/j.resmic.2009.09.0042009Biotransformation, Cloning, Molecular, Gene Expression, Genes, Bacterial, Hydrogen-Ion Concentration, Hydrolysis/drug effects, Lac Operon, Lactobacillus delbrueckii/*enzymology/genetics, Lactose/*metabolism, Sequence Analysis, DNA, Temperature, beta-Galactosidase/genetics/isolation & purification/*metabolismMetabolism
Metabolism20536722Cholesterol removal by some lactic acid bacteria that can be used as probiotic.Tok E, Aslim BMicrobiol Immunol10.1111/j.1348-0421.2010.00219.x2010Bile/metabolism, Cholesterol/*metabolism, Colony Count, Microbial, Food Microbiology, Lactobacillus delbrueckii/*metabolism, Polysaccharides, Bacterial/metabolism, Probiotics/*metabolism, Yogurt/microbiologyBiotechnology
Metabolism21745695Characterization of the cysK2-ctl1-cysE2 gene cluster involved in sulfur metabolism in Lactobacillus casei.Bogicevic B, Irmler S, Portmann R, Meile L, Berthoud HInt J Food Microbiol10.1016/j.ijfoodmicro.2011.06.0152011Carbon-Sulfur Lyases/genetics, Cysteine/biosynthesis, Lactobacillus casei/enzymology/*genetics/metabolism, Methionine/metabolism, Molecular Sequence Data, Multigene Family, *Mutagenesis, Insertional, Open Reading Frames, Sulfur/*metabolismGenetics
Enzymology22283494Homodimeric beta-galactosidase from Lactobacillus delbrueckii subsp. bulgaricus DSM 20081: expression in Lactobacillus plantarum and biochemical characterization.Nguyen TT, Nguyen HA, Arreola SL, Mlynek G, Djinovic-Carugo K, Mathiesen G, Nguyen TH, Haltrich DJ Agric Food Chem10.1021/jf203909e2012Cloning, Molecular, DNA, Bacterial/genetics, Galactose/metabolism, *Gene Expression, Genetic Vectors, Lactobacillus delbrueckii/*enzymology/genetics, Lactobacillus plantarum/*enzymology/genetics, Lactose/metabolism, Protein Multimerization, Recombinant Proteins/biosynthesis/genetics/metabolism, beta-Galactosidase/chemistry/*genetics/metabolismMetabolism
Biotechnology22950663In vivo study of the survival of Lactobacillus delbruecki subsp. bulgaricus CECT 4005T and Streptococcus thermophilus CECT 801 by DVC-FISH after consumption of fermented milk.Garcia-Hernandez J, Moreno Y, Chuan C, Hernandez MJ Food Sci10.1111/j.1750-3841.2012.02918.x2012DNA, Bacterial/genetics, Feces/*microbiology, *Fermentation, Food Microbiology, Gastrointestinal Tract/metabolism/microbiology, Humans, In Situ Hybridization, Fluorescence, Lactobacillus delbrueckii/*growth & development/isolation & purification, Streptococcus thermophilus/*growth & development/isolation & purification, Yogurt/*microbiologyPathogenicity
Metabolism22968410Growth advantage of Streptococcus thermophilus over Lactobacillus bulgaricus in vitro and in the gastrointestinal tract of gnotobiotic rats.Ben-Yahia L, Mayeur C, Rul F, Thomas MBenef Microbes10.3920/BM2012.00122012Animals, Gastrointestinal Tract/*microbiology, Germ-Free Life, Lactic Acid/metabolism, Lactobacillus/*growth & development, Male, Rats, Rats, Inbred F344, Streptococcus thermophilus/*growth & development, Yogurt/microbiology
Phylogeny23181509Isolation and characterization of bacteriocin-producing bacteria from the intestinal microbiota of elderly Irish subjects.Lakshminarayanan B, Guinane CM, O'Connor PM, Coakley M, Hill C, Stanton C, O'Toole PW, Ross RPJ Appl Microbiol10.1111/jam.120852012Aged, Bacterial Proteins/isolation & purification, Bacteriocins/biosynthesis/*isolation & purification, DNA Fingerprinting, DNA, Bacterial/genetics, Enterococcus/genetics/*isolation & purification/metabolism, Feces/microbiology, Humans, Intestines/*microbiology, Ireland, Lactobacillus/genetics/*isolation & purification/metabolism, *Microbiota, Probiotics, RNA, Ribosomal, 16S/geneticsEnzymology
Metabolism24292439Highly stereoselective biosynthesis of (R)-alpha-hydroxy carboxylic acids through rationally re-designed mutation of D-lactate dehydrogenase.Zheng Z, Sheng B, Gao C, Zhang H, Qin T, Ma C, Xu PSci Rep10.1038/srep034012013Biocatalysis, Butyrates/metabolism, Carboxylic Acids/*metabolism, Formate Dehydrogenases/genetics/metabolism, Lactate Dehydrogenases/*genetics/*metabolism, Lactobacillus/genetics/metabolism, Mutation/*genetics, NAD/genetics/metabolism, Phenylpyruvic Acids/metabolism, Pyruvates/metabolismEnzymology
Metabolism25048227Proteomic analysis of the response to NaCl stress of Lactobacillus bulgaricus.Li C, Li PZ, Sun JW, Huo GC, Liu LBBiotechnol Lett10.1007/s10529-014-1601-72014Bacterial Proteins/*analysis/chemistry/metabolism, Electrophoresis, Gel, Two-Dimensional, Freeze Drying, Lactobacillus/*drug effects/metabolism, Proteome/analysis/chemistry/*drug effects/metabolism, Proteomics/*methods, Sodium Chloride/*toxicity, Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization, Stress, Physiological/*drug effectsPathogenicity
Enzymology25089519Efficient production of (R)-2-hydroxy-4-phenylbutyric acid by using a coupled reconstructed D-lactate dehydrogenase and formate dehydrogenase system.Sheng B, Zheng Z, Lv M, Zhang H, Qin T, Gao C, Ma C, Xu PPLoS One10.1371/journal.pone.01042042014Angiotensin-Converting Enzyme Inhibitors/chemical synthesis/chemistry/*metabolism, Escherichia coli/chemistry/genetics/growth & development, Fermentation, Formate Dehydrogenases/biosynthesis/*genetics, Humans, Lactate Dehydrogenases/*genetics/metabolism, Lactobacillus/enzymology, Mutation, Phenylbutyrates/chemical synthesis/metabolism, *Protein EngineeringMetabolism
Metabolism25160914Phosphorylation of uridine and cytidine by uridine-cytidine kinase.Qian Y, Ding Q, Li Y, Zou Z, Yan B, Ou LJ Biotechnol10.1016/j.jbiotec.2014.08.0182014Cytidine/*metabolism, Hydrogen-Ion Concentration, Phosphorylation, Temperature, Uridine/*metabolism, Uridine Kinase/*metabolism
Enzymology25217009Major Role of NAD-Dependent Lactate Dehydrogenases in the Production of l-Lactic Acid with High Optical Purity by the Thermophile Bacillus coagulans.Wang L, Cai Y, Zhu L, Guo H, Yu BAppl Environ Microbiol10.1128/AEM.01864-142014Bacillus/*enzymology/genetics/*metabolism, Fermentation, Gene Expression Profiling, Kinetics, Lactate Dehydrogenases/genetics/*metabolism, Lactic Acid/*metabolism, Lactobacillus delbrueckii/enzymology/genetics/metabolism, Lactobacillus plantarum/enzymology/genetics/metabolismMetabolism
Metabolism25884980Lactobacillus gasseri SBT2055 suppresses fatty acid release through enlargement of fat emulsion size in vitro and promotes fecal fat excretion in healthy Japanese subjects.Ogawa A, Kobayashi T, Sakai F, Kadooka Y, Kawasaki YLipids Health Dis10.1186/s12944-015-0019-02015Adult, Aged, Double-Blind Method, Emulsions/metabolism, Fats/analysis/*metabolism, Fatty Acids/*metabolism, Feces/*chemistry, Female, Humans, Hymecromone/analogs & derivatives/metabolism, Japan, Lactobacillus/*metabolism, Lipase/metabolism, Male, Middle Aged, Particle SizePathogenicity
Biotechnology25940225Enhancing the light-driven production of D-lactate by engineering cyanobacterium using a combinational strategy.Li C, Tao F, Ni J, Wang Y, Yao F, Xu PSci Rep10.1038/srep097772015Combinatorial Chemistry Techniques/methods, Computer Simulation, Genetic Enhancement/*methods, Lactic Acid/*biosynthesis/isolation & purification, Light, *Models, Genetic, Multienzyme Complexes/*genetics, Photosynthesis/*physiology/radiation effects, Recombinant Proteins/genetics, Synechococcus/*physiology/radiation effects, Up-Regulation/physiology/radiation effectsEnzymology
Metabolism26509553Catabolite responsive element deficiency of xyl operon resulting in carbon catabolite derepression in Lactobacillus fermentum 1001.Zhang C, Guo T, Xin Y, Gao X, Kong JJ Appl Microbiol10.1111/jam.129902015Bacterial Proteins/genetics/metabolism, Carbon/*metabolism, Fermentation, *Gene Expression Regulation, Bacterial, Glucose/metabolism, Lactobacillus fermentum/genetics/*metabolism, *Operon, Promoter Regions, Genetic, Xylose/*metabolism
Metabolism26975338Transferase Activity of Lactobacillal and Bifidobacterial beta-Galactosidases with Various Sugars as Galactosyl Acceptors.Arreola SL, Intanon M, Wongputtisin P, Kosma P, Haltrich D, Nguyen THJ Agric Food Chem10.1021/acs.jafc.5b060092016Acetylgalactosamine/analogs & derivatives/metabolism/pharmacokinetics, Acetylglucosamine/metabolism/pharmacokinetics, Bifidobacterium/metabolism, Galactosamine/metabolism, Galactose/*metabolism, Glucosamine/metabolism, Glucose/metabolism, Lactobacillus/*enzymology, Lactobacillus reuteri/metabolism, Lactose/*metabolism, Oligosaccharides/*metabolism, Substrate Specificity, Transferases/*metabolism, beta-Galactosidase/*metabolismEnzymology
28319379Immobilization of beta-Galactosidases from Lactobacillus on Chitin Using a Chitin-Binding Domain.Pham ML, Leister T, Nguyen HA, Do BC, Pham AT, Haltrich D, Yamabhai M, Nguyen TH, Nguyen TTJ Agric Food Chem10.1021/acs.jafc.6b049822017
Metabolism28578054Formation of tyramine in yoghurt during fermentation - Interaction between yoghurt starter bacteria and Lactobacillus plantarum.Yilmaz C, Gokmen VFood Res Int10.1016/j.foodres.2017.04.0142017Amino Acids/analysis/metabolism, Fermentation/physiology, Hydrogen-Ion Concentration, *Lactobacillus plantarum/metabolism/physiology, Microbial Interactions/*physiology, Tyramine/analysis/*metabolism, *Yogurt/analysis/microbiology
29178877Non-sterilized fermentation of high optically pure D-lactic acid by a genetically modified thermophilic Bacillus coagulans strain.Zhang C, Zhou C, Assavasirijinda N, Yu B, Wang L, Ma YMicrob Cell Fact10.1186/s12934-017-0827-12017Bacillus coagulans/*chemistry, Fermentation, Genetic Engineering/*methods, Lactic Acid/*chemistry
Metabolism29627251A selective medium for the enumeration and differentiation of Lactobacillus delbrueckii ssp. bulgaricus.Nwamaioha NO, Ibrahim SAJ Dairy Sci10.3168/jds.2017-141552018Animals, Bifidobacterium/growth & development/metabolism, Culture Media/*chemistry/metabolism, Lactobacillus/growth & development/metabolism, Lactobacillus delbrueckii/*growth & development/metabolism, Yogurt/microbiologyCultivation
30669666Assessment of Ready-to-Use Freeze-dried Immobilized Biocatalysts as Innovative Starter Cultures in Sourdough Bread Making.Mantzourani I, Terpou A, Alexopoulos A, Bezirtzoglou E, Plessas SFoods10.3390/foods80100402019
Metabolism31931839Effects of ccpA gene deficiency in Lactobacillus delbrueckii subsp. bulgaricus under aerobic conditions as assessed by proteomic analysis.Zhang G, Liu L, Li CMicrob Cell Fact10.1186/s12934-020-1278-72020Aerobiosis, Bacterial Proteins/genetics/*metabolism, Gene Deletion, Genes, Bacterial, Lactobacillus delbrueckii/*genetics, Metabolic Engineering/methods, Probiotics/metabolism, *Proteome/genetics/metabolism, Proteomics, Pyruvic Acid/metabolismProteome
Genetics32715364Whole-genome sequencing and genomic-based acid tolerance mechanisms of Lactobacillus delbrueckii subsp. bulgaricus LJJ.Li W, Yang L, Nan W, Lu J, Zhang S, Ujiroghene OJ, Pang X, Lv JAppl Microbiol Biotechnol10.1007/s00253-020-10788-52020Acids/toxicity, Fermentation, Genomics, *Lactobacillus delbrueckii/genetics, *Probiotics
Pathogenicity34387638Global transcriptomic analysis of Lactobacillus delbrueckii subsp. bulgaricus ATCC11842 reveals the role of LDB_RS05285 in the post-acidification of yogurt.Zhang S, Li D, Zhang X, Sun Y, Xu S, Wang X, Zhang N, Wang M, Tian H, Li CFood Funct10.1039/d1fo01357b2021Functional Food, Humans, Hydrogen-Ion Concentration, Lactobacillus delbrueckii/genetics/*metabolism, Taste, Transcriptome, *YogurtTranscriptome
34967915Insights into lactic acid bacteria cryoresistance using FTIR microspectroscopy.Girardeau A, Passot S, Meneghel J, Cenard S, Lieben P, Trelea IC, Fonseca FAnal Bioanal Chem10.1007/s00216-021-03774-x2021Acclimatization, Cold Temperature, Cold-Shock Response, Fatty Acids/analysis, Freezing, Lactobacillales/chemistry/*cytology, Phase Transition, Spectroscopy, Fourier Transform Infrared, Vitrification

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41834Curators of the CIPhttps://brclims.pasteur.fr/brcWeb/souche/detail/1/12557
55042Curators of the CCUGCulture Collection University of Gothenburg (CCUG) (CCUG 41390)https://www.ccug.se/strain?id=41390
66792Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesAutomatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
66794Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg10.1093/nar/gkaa1025BRENDA, the ELIXIR core data resource in 2021: new developments and updatesNucleic Acids Res. 49: D498-D508 202033211880
67770Curators of the JCMhttps://jcm.brc.riken.jp/en/
68371Automatically annotated from API 50CH acid
68382Automatically annotated from API zym
69479João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.https://microbeatlas.org/MicrobeAtlas 1.0 beta
69480Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmannhttps://diaspora-project.de/progress.html#genomesPredictions based on genome sequence made in the Diaspora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
75922Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.10.60712/SI-ID3281.1StrainInfo: A central database for resolving microbial strain identifiers
118884Curators of the CIPCollection of Institut Pasteur (CIP 101027)https://catalogue-crbip.pasteur.fr/fiche_catalogue.xhtml?crbip=CIP%20101027