Archive BacDiveID:10.13145/bacdive23294.20230509.8.1

Strain identifier

BacDive ID: 23294

Type strain:

Species: Staphylococcus aureus

Strain Designation: RN4220

Strain history: <- M. Mosa, IMUNA s.r.o., Praha, Czech Republic <- J. Doskar, Masaryk Univ., Faculty of Science, Brno, Czech Republic <- F. Götz, Univ. Tübingen <- R. P. Novick <- B. Kreisworth and S. Lofdahl

NCBI tax ID(s): 1280 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.

General

@ref: 18922

BacDive-ID: 23294

DSM-Number: 26309

keywords: genome sequence, Bacteria, mesophilic, human pathogen

description: Staphylococcus aureus RN4220 is a mesophilic human pathogen that was isolated from laboratory research strain originally derived from NCTC 8325-4 using UV and chemical mutagenesis.

NCBI tax id

NCBI tax id: 1280
Matching level: species

strain history

@ref: 18922
history: <- M. Mosa, IMUNA s.r.o., Praha, Czech Republic <- J. Doskar, Masaryk Univ., Faculty of Science, Brno, Czech Republic <- F. Götz, Univ. Tübingen <- R. P. Novick <- B. Kreisworth and S. Lofdahl

doi: 10.13145/bacdive23294.20230509.8.1

Name and taxonomic classification

LPSN

@ref: 20215
description: domain/bacteria
keyword: phylum/bacillota
domain: Bacteria
phylum: Bacillota
class: Bacilli
order: Caryophanales
family: Staphylococcaceae
genus: Staphylococcus
species: Staphylococcus aureus
full scientific name: Staphylococcus aureus Rosenbach 1884 (Approved Lists 1980)
synonyms
- @ref: 20215
- synonym: Staphylococcus aureus subsp. anaerobius

@ref: 18922

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Bacillales

family: Staphylococcaceae

genus: Staphylococcus

species: Staphylococcus aureus

full scientific name: Staphylococcus aureus Rosenbach 1884

strain designation: RN4220

type strain: no

Culture and growth conditions

culture medium

@ref: 18922
name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)
growth: yes
link: https://mediadive.dsmz.de/medium/92
composition: Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water

culture temp

@ref: 18922
growth: positive
type: growth
temperature: 37
range: mesophilic

Physiology and metabolism

metabolite utilization

@ref	Chebi-ID	metabolite	utilization activity	kind of utilization tested
68375	16199	urea	-	hydrolysis
68375	29016	arginine	+	hydrolysis
68375	18257	ornithine	-	degradation
68375	4853	esculin	-	hydrolysis
68375	17634	D-glucose	+	fermentation
68375	15824	D-fructose	+	fermentation
68375	16024	D-mannose	+	fermentation
68375	17306	maltose	+	fermentation
68375	17716	lactose	+	fermentation
68375	27082	trehalose	+	fermentation
68375	16899	D-mannitol	+	fermentation
68375	16634	raffinose	-	fermentation
68375	16988	D-ribose	-	fermentation
68375	17057	cellobiose	-	fermentation
68375	17632	nitrate	+	reduction
68375	17992	sucrose	+	fermentation
68375	59640	N-acetylglucosamine	+	fermentation
68375	32528	turanose	+	fermentation
68375	22599	arabinose	-	fermentation

antibiotic resistance

@ref: 68375
ChEBI: 28368
metabolite: novobiocin
is antibiotic: yes
is resistant: yes
resistance conc.: 1.8 µg

metabolite production

@ref: 68375
Chebi-ID: 15688
metabolite: acetoin
production: yes

metabolite tests

@ref: 68375
Chebi-ID: 15688
metabolite: acetoin
voges-proskauer-test: +

enzymes

@ref	value	activity	ec
68375	beta-glucuronidase	-	3.2.1.31
68375	pyrrolidonyl arylamidase	-	3.4.19.3
68375	alkaline phosphatase	+	3.1.3.1
68375	L-arginine arylamidase	-
68375	beta-galactosidase	-	3.2.1.23
68375	beta-glucosidase	-	3.2.1.21
68375	ornithine decarboxylase	-	4.1.1.17
68375	arginine dihydrolase	+	3.5.3.6
68375	urease	-	3.5.1.5

API ID32STA

@ref	URE	ADH Arg	ODC	ESC	GLU	FRU	MNE	MAL	LAC	TRE	MAN	RAF	RIB	CEL	NIT	VP	beta GAL	ArgA	PAL	PyrA	NOVO	SAC	NAG	TUR	ARA	beta GUR
18922	-	+	-	-	+	+	+	+	+	+	+	-	-	-	+	+	-	-	+	-	+	+	+	+	-	-

Isolation, sampling and environmental information

isolation

@ref: 18922
sample type: laboratory research strain originally derived from NCTC 8325-4 using UV and chemical mutagenesis

isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Laboratory
#Host	#Microbial	#Bacteria

Safety information

risk assessment

@ref: 18922
pathogenicity human: yes
pathogenicity animal: yes
biosafety level: 2
biosafety level comment: Risk group (German classification)

Sequence information

Genome sequences

@ref	description	accession	assembly level	database	NCBI tax ID
66792	Staphylococcus aureus subsp. aureus RN4220 RN4220	GCA_018732165	complete	ncbi	561307
66792	Staphylococcus aureus subsp. aureus RN4220	GCA_011751615	scaffold	ncbi	561307
66792	Staphylococcus aureus subsp. aureus RN4220	GCA_000212435	contig	ncbi	561307
66792	Staphylococcus aureus subsp. aureus RN4220	561307.24	complete	patric	561307
66792	Staphylococcus aureus subsp. aureus RN4220	561307.22	wgs	patric	561307
66792	Staphylococcus aureus subsp. aureus RN4220	561307.5	wgs	patric	561307
66792	Staphylococcus aureus subsp. aureus RN4220	GCA_024296825	complete	ncbi	561307

Genome-based predictions

predictions

trait	prediction	confidence	training_data
flagellated	no	92.128	no
gram-positive	yes	88.988	no
anaerobic	no	99.508	no
aerobic	yes	89.085	no
halophile	yes	94.5	no
spore-forming	no	93.424	no
thermophile	no	99.688	no
motile	no	90.356	no
glucose-util	yes	87.555	no
glucose-ferment	yes	86.048	no

External links

@ref: 18922

culture collection no.: DSM 26309

straininfo link

@ref: 87514
straininfo: 405493

literature

topic	Pubmed-ID	title	authors	journal	DOI	year	mesh	topic2
Metabolism	2233255	Inducible erythromycin resistance in staphylococci is encoded by a member of the ATP-binding transport super-gene family.	Ross JI, Eady EA, Cove JH, Cunliffe WJ, Baumberg S, Wootton JC	Mol Microbiol	10.1111/j.1365-2958.1990.tb00696.x	1990	Adenosine Triphosphate/metabolism, Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Base Sequence, Biological Transport, Drug Resistance, Microbial/genetics, Erythromycin/pharmacology, Gene Expression Regulation, Bacterial, Membrane Transport Proteins, Molecular Sequence Data, Multigene Family, Restriction Mapping, Sequence Homology, Nucleic Acid, Staphylococcus epidermidis/drug effects/genetics	Genetics
Enzymology	2559912	Characterisation and molecular cloning of the novel macrolide-streptogramin B resistance determinant from Staphylococcus epidermidis.	Ross JI, Farrell AM, Eady EA, Cove JH, Cunliffe WJ	J Antimicrob Chemother	10.1093/jac/24.6.851	1989	Cloning, Molecular, DNA Restriction Enzymes, DNA, Bacterial/analysis/genetics/isolation & purification, Drug Resistance, Microbial, Microbial Sensitivity Tests, Phenotype, Plasmids, Staphylococcus aureus/drug effects/genetics, Staphylococcus epidermidis/drug effects/genetics, Transformation, Bacterial, Virginiamycin/*pharmacology	Phenotype
Enzymology	3009410	Cloning and expression of the exfoliative toxin B gene from Staphylococcus aureus.	Jackson MP, Iandolo JJ	J Bacteriol	10.1128/jb.166.2.574-580.1986	1986	Bacterial Toxins/genetics, Cadmium/pharmacology, Cloning, Molecular, DNA Restriction Enzymes/metabolism, Drug Resistance, Microbial, Electrophoresis, Agar Gel, Exfoliatins/genetics, Gene Expression Regulation, Immunosorbent Techniques, Staphylococcus aureus/*genetics	Pathogenicity
Enzymology	6411618	Expression of a cloned Staphylococcus aureus alpha-hemolysin determinant in Bacillus subtilis and Staphylococcus aureus.	Fairweather N, Kennedy S, Foster TJ, Kehoe M, Dougan G	Infect Immun	10.1128/iai.41.3.1112-1117.1983	1983	Bacillus subtilis/genetics, Cloning, Molecular, DNA, Bacterial/genetics, Gene Expression Regulation, Hemolysin Factors, Hemolytic Plaque Technique, Plasmids, Staphylococcus aureus/genetics, Transformation, Bacterial
Enzymology	7492103	Analysis of gyrA and grlA mutations in stepwise-selected ciprofloxacin-resistant mutants of Staphylococcus aureus.	Ferrero L, Cameron B, Crouzet J	Antimicrob Agents Chemother	10.1128/AAC.39.7.1554	1995	Ciprofloxacin/pharmacology, DNA Gyrase, DNA Topoisomerase IV, DNA Topoisomerases, Type II/genetics, Drug Resistance, Microbial/genetics, Genes, Bacterial, Mutation, Norfloxacin/pharmacokinetics, Staphylococcus aureus/drug effects/genetics/metabolism	Pathogenicity
Metabolism	7747966	The lysostaphin endopeptidase resistance gene (epr) specifies modification of peptidoglycan cross bridges in Staphylococcus simulans and Staphylococcus aureus.	DeHart HP, Heath HE, Heath LS, LeBlanc PA, Sloan GL	Appl Environ Microbiol	10.1128/aem.61.4.1475-1479.1995	1995	Cell Wall/chemistry/metabolism, Cloning, Molecular, Drug Resistance, Microbial/genetics, Genes, Bacterial, Glycine/analysis, Lysostaphin/metabolism/pharmacology, Peptidoglycan/chemistry/metabolism, Serine/analysis, Staphylococcus/drug effects/genetics/metabolism, Staphylococcus aureus/drug effects/genetics/metabolism	Enzymology
Enzymology	8088537	A genetic and molecular characterization of the recA gene from Staphylococcus aureus.	Bayles KW, Brunskill EW, Iandolo JJ, Hruska LL, Huang S, Pattee PA, Smiley BK, Yasbin RE	Gene	10.1016/0378-1119(94)90033-7	1994	Amino Acid Sequence, Base Sequence, Cloning, Molecular, Genes, Bacterial, Molecular Sequence Data, Mutagenesis, Insertional, Rec A Recombinases/genetics, Restriction Mapping, Staphylococcus aureus/*genetics	Genetics
Pathogenicity	8171126	Molecular characterization of a plasmid-borne (pGT633) erythromycin resistance determinant (ermGT) from Lactobacillus reuteri 100-63.	Tannock GW, Luchansky JB, Miller L, Connell H, Thode-Andersen S, Mercer AA, Klaenhammer TR	Plasmid	10.1006/plas.1994.1007	1994	Amino Acid Sequence, Bacillus subtilis/drug effects/genetics, Bacterial Proteins, Base Sequence, Drug Resistance, Microbial/genetics, Enterococcus faecalis/drug effects/genetics, Erythromycin/toxicity, Genes, Bacterial, Lactobacillus/drug effects/genetics, Methyltransferases/biosynthesis, Molecular Sequence Data, Nucleic Acid Conformation, Open Reading Frames, Plasmids, Protein Sorting Signals/genetics, RNA, Messenger/biosynthesis/chemistry, Restriction Mapping, Staphylococcus aureus/drug effects/genetics, Streptococcus sanguis/drug effects/genetics, *Transformation, Bacterial	Genetics
Genetics	8335347	Lack of complete correlation between emetic and T-cell-stimulatory activities of staphylococcal enterotoxins.	Harris TO, Grossman D, Kappler JW, Marrack P, Rich RR, Betley MJ	Infect Immun	10.1128/iai.61.8.3175-3183.1993	1993	Amino Acid Sequence, Animals, Base Sequence, Enterotoxins/chemistry/immunology/toxicity, Female, Lymphocyte Activation, Macaca mulatta, Mice, Mice, Inbred BALB C, Molecular Sequence Data, Mutation, Staphylococcus aureus/pathogenicity, Structure-Activity Relationship, T-Lymphocytes/immunology, Vomiting/*chemically induced	Pathogenicity
Pathogenicity	8432600	Toxicity of recombinant toxic shock syndrome toxin 1 and mutant toxins produced by Staphylococcus aureus in a rabbit infection model of toxic shock syndrome.	Bonventre PF, Heeg H, Cullen C, Lian CJ	Infect Immun	10.1128/iai.61.3.793-799.1993	1993	Animals, Antibodies, Monoclonal, Bacterial Toxins, Blood Chemical Analysis, Enterotoxins/immunology/toxicity, Mitogens, Rabbits, Recombinant Proteins/toxicity, Shock, Septic/physiopathology, Staphylococcus aureus/pathogenicity, Structure-Activity Relationship, *Superantigens
Phenotype	8515230	Recombination at the coagulase locus in Staphylococcus aureus: plasmid integration and amplification.	McDevitt D, Wann ER, Foster TJ	J Gen Microbiol	10.1099/00221287-139-4-695	1993	Alleles, Blotting, Southern, Coagulase/genetics, Gene Amplification, Genes, Bacterial, Mutagenesis, Phenotype, Plasmids, Recombination, Genetic, Staphylococcus aureus/enzymology/genetics, Transduction, Genetic, Transformation, Genetic	Enzymology
Genetics	8723458	Alterations in the DNA topoisomerase IV grlA gene responsible for quinolone resistance in Staphylococcus aureus.	Yamagishi J, Kojima T, Oyamada Y, Fujimoto K, Hattori H, Nakamura S, Inoue M	Antimicrob Agents Chemother	10.1128/AAC.40.5.1157	1996	Amino Acid Sequence, Base Sequence, DNA Topoisomerase IV, DNA Topoisomerases, Type II/analysis/genetics, Drug Resistance, Microbial/genetics, Genes, Bacterial/genetics, Molecular Sequence Data, Mutagenesis, Site-Directed, Mutation, Open Reading Frames, Plasmids/genetics, Quinolones/chemistry, Sequence Analysis, DNA, Staphylococcus aureus/drug effects/enzymology/genetics	Transcriptome
Enzymology	8795206	Purification and partial characterization of a novel antibacterial agent (Bac1829) Produced by Staphylococcus aureus KSI1829.	Crupper SS, Iandolo JJ	Appl Environ Microbiol	10.1128/aem.62.9.3171-3175.1996	1996	Bacteria/drug effects, Bacteriocins/isolation & purification/metabolism/pharmacology, Dose-Response Relationship, Drug, Staphylococcus aureus/*metabolism	Metabolism
Phenotype	8869496	Suppression of the thermosensitive replication phenotype of the derivative plasmid of pI9789::Tn552 in Staphylococcus aureus may involve integration of the plasmid into the host chromosome.	Sohail M, Dyke KG	FEMS Microbiol Lett	10.1111/j.1574-6968.1996.tb08038.x	1996	Arsenates/antagonists & inhibitors, Blotting, Southern, Cadmium/antagonists & inhibitors, Chromosomes, Bacterial/genetics, Gene Deletion, Herbicides/antagonists & inhibitors, Lysogeny/genetics, Mercury/antagonists & inhibitors, Penicillins/antagonists & inhibitors, Phenotype, Plasmids/genetics, R Factors/genetics, Replicon/genetics, Restriction Mapping, Staphylococcus aureus/*genetics, Temperature	Pathogenicity
Phenotype	8996099	Minimal functional system required for expression of erythromycin resistance by msrA in Staphylococcus aureus RN4220.	Ross JI, Eady EA, Cove JH, Baumberg S	Gene	10.1016/s0378-1119(96)00541-0	1996	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/physiology, Carrier Proteins/genetics/physiology, Chromosomes, Bacterial/genetics, Crossing Over, Genetic, Drug Resistance, Microbial/genetics, Erythromycin/pharmacology, Gene Expression Regulation, Bacterial/genetics, Membrane Proteins/genetics/physiology, Membrane Transport Proteins, Phenotype, Sequence Deletion, Staphylococcus aureus/drug effects/genetics, Virginiamycin/pharmacology	Pathogenicity
Enzymology	9116505	Purification of Staphylococcus aureus beta-toxin: comparison of three isoelectric focusing methods.	Gaskin DK, Bohach GA, Schlievert PM, Hovde CJ	Protein Expr Purif	10.1006/prep.1996.0664	1997	Bacterial Toxins/isolation & purification, Electrophoresis, Polyacrylamide Gel, Hemolysin Proteins, Immunoblotting, Isoelectric Focusing/methods, Sphingomyelin Phosphodiesterase/isolation & purification, Staphylococcus aureus/chemistry	Phylogeny
Pathogenicity	9333072	Quinolone susceptibility of norA-disrupted Staphylococcus aureus.	Yamada H, Kurose-Hamada S, Fukuda Y, Mitsuyama J, Takahata M, Minami S, Watanabe Y, Narita H	Antimicrob Agents Chemother	10.1128/AAC.41.10.2308	1997	4-Quinolones, Anti-Infective Agents/chemistry/pharmacology, Blotting, Southern, Drug Resistance, Microbial, Genes, Bacterial/genetics/physiology, Microbial Sensitivity Tests, Mutation, Staphylococcus aureus/drug effects/genetics
Enzymology	9361432	Recombinant luminescent bacteria for measuring bioavailable arsenite and antimonite.	Tauriainen S, Karp M, Chang W, Virta M	Appl Environ Microbiol	10.1128/aem.63.11.4456-4461.1997	1997	Antimony/pharmacokinetics/toxicity, Arsenites/pharmacokinetics/toxicity, Bacteria/metabolism, Biological Availability, DNA, Recombinant, Luminescent Measurements, Plasmids	Metabolism
Enzymology	9573165	Penicillin-binding protein 1 of Staphylococcus aureus is essential for growth.	Wada A, Watanabe H	J Bacteriol	10.1128/JB.180.10.2759-2765.1998	1998	Amino Acid Sequence, Bacterial Proteins, Base Sequence, Carrier Proteins/genetics/physiology, Cloning, Molecular, Hexosyltransferases, Molecular Sequence Data, Muramoylpentapeptide Carboxypeptidase/genetics/physiology, Penicillin-Binding Proteins, Peptidyl Transferases, Sequence Alignment, Sequence Homology, Amino Acid, Staphylococcus aureus/genetics/growth & development	Genetics
Pathogenicity	9624482	A new ketolide, HMR 3004, active against streptococci inducibly resistant to erythromycin.	Rosato A, Vicarini H, Bonnefoy A, Chantot JF, Leclercq R	Antimicrob Agents Chemother	10.1128/AAC.42.6.1392	1998	Anti-Bacterial Agents/pharmacology, Artificial Gene Fusion, Base Sequence, DNA, Bacterial/drug effects/genetics, Drug Resistance, Microbial, Enterococcus/drug effects/genetics, Erythromycin/pharmacology, Ketolides, Macrolides, Molecular Sequence Data, Sequence Alignment, Streptococcus/*drug effects/genetics	Genetics
Enzymology	9687416	Effects of mutations in GrlA of topoisomerase IV from Staphylococcus aureus on quinolone and coumarin activity.	Fournier B, Hooper DC	Antimicrob Agents Chemother	10.1128/AAC.42.8.2109	1998	Alleles, Anti-Infective Agents/pharmacology, Coumarins/pharmacology, DNA Topoisomerase IV, DNA Topoisomerases, Type II/genetics, Drug Resistance, Microbial, Fluoroquinolones, Mutation, Staphylococcus aureus/drug effects/*enzymology	Pathogenicity
Pathogenicity	9839381	Luminescent bacterial sensor for cadmium and lead.	Tauriainen S, Karp M, Chang W, Virta M	Biosens Bioelectron	10.1016/s0956-5663(98)00027-x	1998	Animals, Bacillus subtilis/drug effects/enzymology/genetics, Base Sequence, Biosensing Techniques/methods, Cadmium/analysis/pharmacology, Coleoptera/enzymology/genetics, DNA Primers/genetics, Freeze Drying, Gene Expression Regulation, Enzymologic/drug effects, Genes, Reporter/drug effects, Lead/*analysis/pharmacology, Luciferases/genetics, Luminescent Measurements, Plasmids/genetics, Staphylococcus aureus/drug effects/genetics	Enzymology
Genetics	9919657	Genetic analysis of the cap5 locus of Staphylococcus aureus.	Wann ER, Dassy B, Fournier JM, Foster TJ	FEMS Microbiol Lett	10.1111/j.1574-6968.1999.tb13360.x	1999	Bacterial Capsules/biosynthesis/chemistry/genetics, Bacterial Proteins/genetics, Blotting, Southern, Carbohydrate Sequence, DNA Transposable Elements, DNA, Bacterial, Genetic Complementation Test, Molecular Sequence Data, Mutation, Restriction Mapping, Serotyping, Staphylococcus aureus/classification/*genetics, Transduction, Genetic	Phylogeny
Enzymology	10428901	Activities of trovafloxacin compared with those of other fluoroquinolones against purified topoisomerases and gyrA and grlA mutants of Staphylococcus aureus.	Gootz TD, Zaniewski RP, Haskell SL, Kaczmarek FS, Maurice AE	Antimicrob Agents Chemother	10.1128/AAC.43.8.1845	1999	Adrenergic Uptake Inhibitors/pharmacology, Anti-Infective Agents/pharmacology, Antitubercular Agents/pharmacology, Ciprofloxacin/pharmacology, DNA Gyrase, DNA Topoisomerase IV, DNA Topoisomerases, Type II/genetics/isolation & purification/metabolism, DNA, Bacterial/biosynthesis/metabolism, DNA, Superhelical/metabolism, Drug Interactions, Drug Resistance, Microbial, Enzyme Inhibitors/pharmacology, Fluoroquinolones, Levofloxacin, Microbial Sensitivity Tests, Mutation, Naphthyridines/pharmacology, Ofloxacin/pharmacology, Reserpine/pharmacology, Staphylococcus aureus/drug effects/enzymology/genetics/isolation & purification, Topoisomerase II Inhibitors	Metabolism
Enzymology	10436926	Transposition of IS1181 in the genomes of Staphylococcus and Listeria.	Chesneau O, Lailler R, Derbise A, El Solh N	FEMS Microbiol Lett	10.1111/j.1574-6968.1999.tb13718.x	1999	Base Sequence, Cloning, Molecular/methods, DNA Transposable Elements, DNA, Bacterial/chemistry/genetics, Genetic Vectors, Genome, Bacterial, Listeria monocytogenes/genetics, Mutagenesis, Insertional/methods, Plasmids, Restriction Mapping, Staphylococcus/genetics, Staphylococcus aureus/genetics	Genetics
Pathogenicity	10543753	Effects of genes encoding resistance to streptogramins A and B on the activity of quinupristin-dalfopristin against Enterococcus faecium.	Bozdogan B, Leclercq R	Antimicrob Agents Chemother	10.1128/AAC.43.11.2720	1999	Acetyltransferases/genetics, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Drug Resistance, Microbial, Enterococcus faecium/drug effects/genetics, Genes, Bacterial/genetics, Genotype, Gram-Positive Bacterial Infections/microbiology, Hemeproteins/genetics, Humans, Methyltransferases/genetics, Microbial Sensitivity Tests, Plasmids/genetics, Polymerase Chain Reaction, Staphylococcus aureus/drug effects, Virginiamycin/*pharmacology	Genetics
Genetics	10873532	A method for demonstrating gene essentiality in Staphylococcus aureus.	Jana M, Luong TT, Komatsuzawa H, Shigeta M, Lee CY	Plasmid	10.1006/plas.2000.1473	2000	Base Sequence, Genes, Bacterial, Genes, Essential, Molecular Sequence Data, Peptide Synthases/genetics, Staphylococcus aureus/enzymology/genetics/growth & development	Enzymology
Metabolism	11344159	Biosynthesis of the glycolipid anchor in lipoteichoic acid of Staphylococcus aureus RN4220: role of YpfP, the diglucosyldiacylglycerol synthase.	Kiriukhin MY, Debabov DV, Shinabarger DL, Neuhaus FC	J Bacteriol	10.1128/JB.183.11.3506-3514.2001	2001	Animals, Bacterial Proteins/genetics/metabolism, Escherichia coli/enzymology/genetics, Glucose/metabolism, Glucosyltransferases/genetics/metabolism, Glycolipids/metabolism, Glycosyltransferases, Lipopolysaccharides/metabolism, Mice, Microscopy, Electron, Scanning, Mutation, Staphylococcal Infections/microbiology, Staphylococcus aureus/enzymology/genetics/growth & development/pathogenicity, Teichoic Acids/*metabolism, Virulence	Enzymology
Pathogenicity	11368915	Phage conversion of Panton-Valentine leukocidin in Staphylococcus aureus: molecular analysis of a PVL-converting phage, phiSLT.	Narita S, Kaneko J, Chiba J, Piemont Y, Jarraud S, Etienne J, Kamio Y	Gene	10.1016/s0378-1119(01)00390-0	2001	Amino Acid Sequence, Bacterial Proteins, Bacterial Toxins, Base Sequence, Capsid/biosynthesis/genetics, Exotoxins, Gene Conversion, Genome, Viral, Humans, Leukocidins/genetics, Lysogeny/physiology, Membrane Proteins/genetics, Molecular Sequence Data, Operon, Promoter Regions, Genetic, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Staphylococcus Phages/genetics/isolation & purification, Staphylococcus aureus/genetics/pathogenicity/virology, Terminator Regions, Genetic, Viral Proteins/analysis, Virus Replication	Genetics
Metabolism	11535794	The Fbe (SdrG) protein of Staphylococcus epidermidis HB promotes bacterial adherence to fibrinogen.	Hartford O, O'Brien L, Schofield K, Wells J, Foster TJ	Microbiology (Reading)	10.1099/00221287-147-9-2545	2001	Adhesins, Bacterial/genetics/physiology, Bacterial Adhesion/genetics/physiology, Bacterial Proteins/genetics/physiology, Base Sequence, Carrier Proteins/genetics/physiology, DNA Transposable Elements/genetics, DNA, Bacterial/genetics, Fibrinogen/metabolism, Gene Expression, Genes, Bacterial, Mutation, Plasmids/genetics, Staphylococcus epidermidis/genetics/physiology
Metabolism	11673420	Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP2) by the drug resistance protein PBP2A in Staphylococcus aureus.	Pinho MG, Filipe SR, de Lencastre H, Tomasz A	J Bacteriol	10.1128/JB.183.22.6525-6531.2001	2001	Aminoacyltransferases/metabolism, Bacterial Proteins, Carrier Proteins/genetics/metabolism, Drug Resistance, Bacterial, Hexosyltransferases, Methicillin/pharmacology, Muramoylpentapeptide Carboxypeptidase/deficiency/genetics/metabolism, Penicillin-Binding Proteins, Penicillins/pharmacology, Peptidyl Transferases, Staphylococcus aureus/drug effects/genetics/*metabolism, Transcription, Genetic	Pathogenicity
Cultivation	11709324	Measurement of effects of antibiotics in bioluminescent Staphylococcus aureus RN4220.	Tenhami M, Hakkila K, Karp M	Antimicrob Agents Chemother	10.1128/AAC.45.12.3456-3461.2001	2001	Anti-Bacterial Agents/pharmacology, Culture Media, Drug Evaluation, Preclinical, Hydrogen-Ion Concentration, Luminescent Measurements, Microbial Sensitivity Tests/methods, Photometry, Staphylococcus aureus/*drug effects	Pathogenicity
Metabolism	11751840	Direct quantitation of the numbers of individual penicillin-binding proteins per cell in Staphylococcus aureus.	Pucci MJ, Dougherty TJ	J Bacteriol	10.1128/JB.184.2.588-591.2002	2002	Bacterial Proteins, Carrier Proteins/metabolism, Densitometry/methods, Hexosyltransferases, Isotope Labeling, Lasers, Methicillin Resistance, Muramoylpentapeptide Carboxypeptidase/metabolism, Penicillin G/metabolism, Penicillin-Binding Proteins, Peptidyl Transferases, Staphylococcus aureus/growth & development/metabolism, Tritium
Cultivation	11822776	Genetic linkage between resistance to quaternary ammonium compounds and beta-lactam antibiotics in food-related Staphylococcus spp.	Sidhu MS, Heir E, Sorum H, Holck A	Microb Drug Resist	10.1089/10766290152773374	2001	Anti-Bacterial Agents/pharmacology, Anti-Infective Agents, Local/pharmacology, Benzalkonium Compounds/pharmacology, Blotting, Southern, Culture Media, DNA, Bacterial/genetics/isolation & purification, Drug Resistance, Microbial, Food Microbiology, Hybridization, Genetic, Microbial Sensitivity Tests, Plasmids/genetics, Quaternary Ammonium Compounds/pharmacology, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus/drug effects/growth & development, Transformation, Bacterial/genetics, beta-Lactam Resistance/genetics, beta-Lactams	Biotechnology
Pathogenicity	12069975	Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus.	Malbruny B, Canu A, Bozdogan B, Fantin B, Zarrouk V, Dutka-Malen S, Feger C, Leclercq R	Antimicrob Agents Chemother	10.1128/AAC.46.7.2200-2207.2002	2002	Amino Acid Sequence, Bacterial Proteins/genetics, Drug Resistance, Microbial/genetics, Drug Therapy, Combination/pharmacology, Humans, Molecular Sequence Data, Mutation, RNA, Ribosomal, 23S/genetics, RNA-Binding Proteins/chemistry/genetics, Ribosomal Proteins, Ribosomes/metabolism, Staphylococcus aureus/drug effects/genetics, Virginiamycin/pharmacology	Genetics
Metabolism	12121924	Small-colony mutants of Staphylococcus aureus allow selection of gyrase-mediated resistance to dual-target fluoroquinolones.	Pan XS, Hamlyn PJ, Talens-Visconti R, Alovero FL, Manzo RH, Fisher LM	Antimicrob Agents Chemother	10.1128/AAC.46.8.2498-2506.2002	2002	Anti-Infective Agents/pharmacology, Coagulase/metabolism, DNA Gyrase/biosynthesis/genetics/metabolism, DNA Topoisomerase IV/genetics/metabolism, Drug Resistance, Microbial, Fluoroquinolones, Hemin/metabolism, Microbial Sensitivity Tests, Mutation/genetics, Phenotype, Quinolones/pharmacology, Staphylococcus aureus/enzymology/*genetics, Thymidine/metabolism, Vitamin K 3/metabolism	Phenotype
Pathogenicity	12161395	Insertional inactivation of mutS in Staphylococcus aureus reveals potential for elevated mutation frequencies, although the prevalence of mutators in clinical isolates is low.	O'Neill AJ, Chopra I	J Antimicrob Chemother	10.1093/jac/dkf118	2002	Adenosine Triphosphatases/genetics, Bacterial Proteins, DNA-Binding Proteins, Escherichia coli Proteins/genetics, Humans, MutS DNA Mismatch-Binding Protein, Mutagenesis, Insertional/methods, Mutation/genetics, Sequence Analysis, DNA/methods, Staphylococcus aureus/genetics/isolation & purification	Transcriptome
Pathogenicity	12384362	An elevated mutation frequency favors development of vancomycin resistance in Staphylococcus aureus.	Schaaff F, Reipert A, Bierbaum G	Antimicrob Agents Chemother	10.1128/AAC.46.11.3540-3548.2002	2002	Adenosine Triphosphatases/genetics, Anti-Bacterial Agents/pharmacology, Antibiotics, Antitubercular/pharmacology, Bacterial Proteins, Bacteriophage Typing, DNA-Binding Proteins, Drug Resistance, Microbial, Escherichia coli Proteins/genetics, Genetic Complementation Test, Microbial Sensitivity Tests, MutS DNA Mismatch-Binding Protein, Mutation/genetics, Rifampin/pharmacology, Staphylococcus aureus/drug effects/genetics/growth & development, Teicoplanin/pharmacology, Vancomycin Resistance/*genetics
Pathogenicity	12443831	Characterization of a holin (HolNU3-1) in methicillin-resistant Staphylococcus aureus host.	Horii T, Suzuki Y, Kobayashi M	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.2002.tb00638.x	2002	Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Bacteriophages, Cloning, Molecular, Evolution, Molecular, Humans, Methicillin Resistance, Molecular Sequence Data, N-Acetylmuramoyl-L-alanine Amidase, Sequence Analysis, DNA, Sequence Homology, Amino Acid, Staphylococcal Infections/microbiology, Staphylococcus aureus/*drug effects/genetics/metabolism	Metabolism
Pathogenicity	12519196	Molecular analysis of fusidic acid resistance in Staphylococcus aureus.	Besier S, Ludwig A, Brade V, Wichelhaus TA	Mol Microbiol	10.1046/j.1365-2958.2003.03307.x	2003	Amino Acid Sequence, Amino Acid Substitution, Anti-Bacterial Agents/pharmacology, Cloning, Molecular, Drug Resistance, Bacterial/genetics, Fusidic Acid/pharmacology, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mutagenesis, Site-Directed, Peptide Elongation Factor G/chemistry/genetics, Point Mutation, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/*drug effects/genetics	Enzymology
Pathogenicity	12677529	Biflavonoids with cytotoxic and antibacterial activity from Ochna macrocalyx.	Tang S, Bremner P, Kortenkamp A, Schlage C, Gray AI, Gibbons S, Heinrich M	Planta Med	10.1055/s-2003-38478	2003	Anti-Bacterial Agents/pharmacology, Antineoplastic Agents, Phytogenic/pharmacology, Breast Neoplasms/drug therapy/pathology, Drug Resistance, Multiple, Flavonoids/chemistry/pharmacology, Humans, Magnetic Resonance Spectroscopy, Malpighiaceae, Microbial Sensitivity Tests, NF-kappa B/antagonists & inhibitors, Phytotherapy, Plant Bark, Plant Extracts/chemistry/pharmacology, Staphylococcus aureus/drug effects, Tumor Cells, Cultured/drug effects
Pathogenicity	12726988	Inactivation of mprF affects vancomycin susceptibility in Staphylococcus aureus.	Ruzin A, Severin A, Moghazeh SL, Etienne J, Bradford PA, Projan SJ, Shlaes DM	Biochim Biophys Acta	10.1016/s0304-4165(03)00028-x	2003	Aminoacyltransferases, Bacterial Proteins/genetics/physiology, DNA Transposable Elements, Microbial Sensitivity Tests, Mutagenesis, Insertional, Staphylococcus aureus/drug effects, Vancomycin Resistance/*genetics
	15000739	Effect of disruption of Staphylococcus aureus PBP4 gene on resistance to beta-lactam antibiotics.	Katayama Y, Zhang HZ, Chambers HF	Microb Drug Resist	10.1089/107662903322762752	2003	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carrier Proteins/genetics, DNA, Bacterial/genetics, Electroporation, Genes, Bacterial/genetics, Genetic Complementation Test, Hexosyltransferases/genetics, Muramoylpentapeptide Carboxypeptidase/genetics, Mutagenesis, Nafcillin/pharmacology, Penicillin-Binding Proteins, Penicillins/pharmacology, Peptidyl Transferases/genetics, Plasmids/genetics, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/genetics/growth & development, beta-Lactam Resistance/genetics
Metabolism	15073314	Low-proline environments impair growth, proline transport and in vivo survival of Staphylococcus aureus strain-specific putP mutants.	Schwan WR, Wetzel KJ, Gomez TS, Stiles MA, Beitlich BD, Grunwald S	Microbiology (Reading)	10.1099/mic.0.26710-0	2004	Amino Acid Transport Systems, Neutral/genetics/metabolism, Animals, Culture Media, Escherichia coli/genetics/metabolism, Humans, Lethal Dose 50, Mice, Mice, Inbred BALB C, Mutation, Plasmids, Proline/metabolism, Species Specificity, Staphylococcal Infections/microbiology/physiopathology, Staphylococcus aureus/classification/genetics/growth & development/*pathogenicity, Virulence	Phylogeny
Pathogenicity	15287009	Discarding multidrug resistance inducers, the possible role of a biosensing reporter in antimicrobial discovery.	Galluzzi L, Virtanen P, Karp M	Luminescence	10.1002/bio.771	2004	Biosensing Techniques, Disinfectants/pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Microbial/genetics, Drug Resistance, Multiple/genetics, Genes, Reporter, Plasmids, Staphylococcus aureus/drug effects/*genetics
Pathogenicity	15336408	The cme gene of Clostridium difficile confers multidrug resistance in Enterococcus faecalis.	Lebel S, Bouttier S, Lambert T	FEMS Microbiol Lett	10.1016/j.femsle.2004.07.022	2004	Amino Acid Sequence, Anti-Bacterial Agents/metabolism/pharmacology, Bacterial Proteins/chemistry/genetics/metabolism, Biological Transport, Active, Cloning, Molecular, Clostridioides difficile/genetics, Consensus Sequence, DNA, Bacterial/chemistry/genetics/isolation & purification, Drug Resistance, Multiple, Bacterial/genetics, Enterococcus faecalis/drug effects/genetics, Erythromycin/pharmacology, Ethidium/pharmacology, Gene Expression, Genes, Bacterial, Molecular Sequence Data, Multidrug Resistance-Associated Proteins, Open Reading Frames, Phenazines/pharmacology, Recombinant Proteins/metabolism, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology, Staphylococcus aureus/drug effects/genetics	Metabolism
Pathogenicity	15471995	Nucleotide sequence and organization of the multiresistance plasmid pSCFS1 from Staphylococcus sciuri.	Kehrenberg C, Ojo KK, Schwarz S	J Antimicrob Chemother	10.1093/jac/dkh457	2004	ATP-Binding Cassette Transporters/genetics/physiology, Base Sequence, Drug Resistance, Multiple, Bacterial/genetics, Open Reading Frames, Plasmids, Staphylococcus/drug effects/genetics
Metabolism	15477462	Intravitreally injected human immunoglobulin attenuates the effects of Staphylococcus aureus culture supernatant in a rabbit model of toxin-mediated endophthalmitis.	Perkins SL, Han DP, Burke JM, Schlievert PM, Wirostko WJ, Tarasewicz DG, Skumatz CM	Arch Ophthalmol	10.1001/archopht.122.10.1499	2004	Animals, Bacterial Toxins/immunology/metabolism/pharmacology, Culture Media/metabolism, Disease Models, Animal, Endophthalmitis/immunology/pathology/therapy, Enterotoxins/immunology/metabolism/pharmacology, Hemolysin Proteins, Humans, Immunoglobulins/pharmacology, Immunotherapy/methods, Rabbits, Retina/immunology/pathology, Sphingomyelin Phosphodiesterase/immunology/metabolism/pharmacology, Staphylococcus aureus/metabolism, Superantigens/immunology/metabolism/pharmacology, Vitreous Body/immunology/pathology	Pathogenicity
Phenotype	15519475	Bactericidal activity of quinupristin-dalfopristin against strains of Staphylococcus aureus with the MLS(B) phenotype of resistance according to the erm gene type.	Clarebout G, Nativelle E, Bozdogan B, Villers C, Leclercq R	Int J Antimicrob Agents	10.1016/j.ijantimicag.2004.06.016	2004	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Drug Resistance, Bacterial/genetics, Genes, Bacterial/genetics, Genotype, Methyltransferases/genetics, Microbial Sensitivity Tests/methods, Phenotype, Staphylococcus aureus/drug effects/enzymology, Virginiamycin/*pharmacology	Genetics
Pathogenicity	15531595	Comparison of assays for detection of agents causing membrane damage in Staphylococcus aureus.	O'Neill AJ, Miller K, Oliva B, Chopra I	J Antimicrob Chemother	10.1093/jac/dkh476	2004	Anti-Bacterial Agents/pharmacology, Bacteriolysis, Cell Membrane/drug effects, Cell Membrane Permeability/drug effects, Cetrimonium, Cetrimonium Compounds/pharmacology, Microbial Sensitivity Tests, Nisin/pharmacology, Protoplasts/drug effects, Staphylococcus aureus/*drug effects/enzymology/genetics, beta-Galactosidase/genetics/metabolism	Enzymology
Pathogenicity	15638329	Characterization of a bifunctional aminoglycoside-modifying enzyme with novel substrate specificity and its gene from a clinical isolate of methicillin-resistant Staphylococcus aureus with high arbekacin resistance.	Ishino K, Ishikawa J, Ikeda Y, Hotta K	J Antibiot (Tokyo)	10.7164/antibiotics.57.679	2004	Amino Acid Sequence, Aminoglycosides/metabolism/pharmacology, Dibekacin/analogs & derivatives/pharmacology, Drug Resistance, Bacterial, Humans, Methicillin Resistance, Molecular Sequence Data, Phosphorylation, RNA, Messenger/analysis, Staphylococcus aureus/drug effects/enzymology/genetics, Substrate Specificity	Enzymology
Pathogenicity	15649995	Enhanced resistance to erythromycin is conferred by the enterococcal msrC determinant in Staphylococcus aureus.	Reynolds E, Cove JH	J Antimicrob Chemother	10.1093/jac/dkh541	2005	Bacterial Proteins/genetics/isolation & purification, Base Sequence, Drug Resistance, Bacterial/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Erythromycin/pharmacology, Molecular Sequence Data, Staphylococcus aureus/drug effects/*genetics	Genetics
Pathogenicity	15747765	Intravitreal human immune globulin in a rabbit model of Staphylococcus aureus toxin-mediated endophthalmitis: a potential adjunct in the treatment of endophthalmitis.	Han DP	Trans Am Ophthalmol Soc		2004	Animals, Bacterial Toxins, Drug Administration Schedule, Endophthalmitis/chemically induced/metabolism/pathology, Exotoxins, Feasibility Studies, Humans, Immunoglobulins/administration & dosage/metabolism/pharmacology, Injections, Rabbits, Staphylococcus aureus, *Vitreous Body	Metabolism
Enzymology	15817797	Sau42I, a BcgI-like restriction-modification system encoded by the Staphylococcus aureus quadruple-converting phage Phi42.	Dempsey RM, Carroll D, Kong H, Higgins L, Keane CT, Coleman DC	Microbiology (Reading)	10.1099/mic.0.27646-0	2005	Amino Acid Sequence, Chromosome Mapping, Cloning, Molecular, DNA Restriction-Modification Enzymes/genetics/metabolism, Escherichia coli/genetics, Genes, Viral, Lysogeny, Molecular Sequence Data, Open Reading Frames, Phenotype, Sequence Homology, Amino Acid, Staphylococcus Phages/classification/genetics/metabolism, Staphylococcus aureus/virology	Metabolism
Enzymology	15866932	Role of mutS and mutL genes in hypermutability and recombination in Staphylococcus aureus.	Prunier AL, Leclercq R	J Bacteriol	10.1128/JB.187.10.3455-3464.2005	2005	Adenosine Triphosphatases/genetics, Bacterial Proteins/genetics, Cloning, Molecular, DNA Repair Enzymes/genetics, DNA-Binding Proteins/genetics, Escherichia coli Proteins, MutS DNA Mismatch-Binding Protein, Mutation/genetics, Operon/genetics, Phenotype, Recombination, Genetic/genetics, Staphylococcus aureus/classification/enzymology/*genetics	Phenotype
Genetics	15980097	Staphylococcal tetracycline-MLSB resistance plasmid pSTE2 is the product of an RSA-mediated in vivo recombination.	Hauschild T, Luthje P, Schwarz S	J Antimicrob Chemother	10.1093/jac/dki207	2005	Anti-Bacterial Agents/pharmacology, Base Sequence, Drug Resistance, Multiple, Bacterial/genetics, Genes, Bacterial, Molecular Sequence Data, Plasmids/genetics, Recombination, Genetic, Staphylococcus/drug effects/genetics, Tetracycline Resistance/genetics	Pathogenicity
Pathogenicity	16468992	A slipped-mispairing mutation in AgrA of laboratory strains and clinical isolates results in delayed activation of agr and failure to translate delta- and alpha-haemolysins.	Traber K, Novick R	Mol Microbiol	10.1111/j.1365-2958.2006.04986.x	2006	Adenine, Amino Acid Sequence, Bacterial Proteins/genetics/metabolism, Bacterial Toxins/genetics/metabolism, Base Sequence, Frameshift Mutation, Gene Expression Regulation, Bacterial, Genetic Complementation Test, Hemolysin Proteins, Humans, Laboratories, Methylnitronitrosoguanidine/pharmacology, Molecular Sequence Data, Protein Biosynthesis, Staphylococcus aureus/drug effects/genetics/isolation & purification, Trans-Activators/*genetics/metabolism	Metabolism
Enzymology	16644226	A novel antimicrobial epoxide isolated from larval Galleria mellonella infected by the nematode symbiont, Photorhabdus luminescens (Enterobacteriaceae).	Hu K, Li J, Li B, Webster JM, Chen G	Bioorg Med Chem	10.1016/j.bmc.2006.01.025	2006	Animals, Anti-Bacterial Agents/chemistry/isolation & purification/pharmacology, Antibiotics, Antineoplastic/chemistry/isolation & purification/pharmacology, Bacteria/drug effects, Cell Line, Tumor, Epoxy Compounds/chemistry/isolation & purification/pharmacology, Humans, Larva/chemistry/microbiology, Lepidoptera/metabolism/microbiology, Mice, Phenoxypropanolamines/chemistry/isolation & purification/pharmacology, Photorhabdus, Propylamines/chemistry/isolation & purification/*pharmacology	Phylogeny
Enzymology	16855248	Sau1: a novel lineage-specific type I restriction-modification system that blocks horizontal gene transfer into Staphylococcus aureus and between S. aureus isolates of different lineages.	Waldron DE, Lindsay JA	J Bacteriol	10.1128/JB.00418-06	2006	Bacterial Proteins/genetics, DNA Restriction-Modification Enzymes/genetics, Deoxyribonucleases, Type I Site-Specific/genetics/physiology, Gene Transfer, Horizontal, Genes, Bacterial, Genetic Variation, Species Specificity, Staphylococcus aureus/drug effects/enzymology/genetics, Vancomycin Resistance	Phylogeny
Metabolism	17198402	Repression of Staphylococcus aureus SrrAB using inducible antisense srrA alters growth and virulence factor transcript levels.	Pragman AA, Ji Y, Schlievert PM	Biochemistry	10.1021/bi0603266	2007	Bacterial Proteins/antagonists & inhibitors/genetics/metabolism/physiology, Down-Regulation, Gene Expression Regulation, Bacterial, Metabolism, Models, Biological, RNA, Antisense/metabolism, RNA, Bacterial/metabolism, Repressor Proteins/antagonists & inhibitors/genetics/metabolism/physiology, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/genetics/growth & development/pathogenicity, Time Factors, Transcription, Genetic, Virulence Factors/*genetics/metabolism
Enzymology	17329268	Identification and characterization of nine novel types of small staphylococcal plasmids carrying the lincosamide nucleotidyltransferase gene lnu(A).	Luthje P, von Kockritz-Blickwede M, Schwarz S	J Antimicrob Chemother	10.1093/jac/dkm008	2007	Animals, Anti-Bacterial Agents/pharmacology, Blotting, Southern, Cattle, DNA, Bacterial/genetics, Drug Resistance, Bacterial/genetics, Female, Gene Dosage, Gene Expression Regulation, Bacterial/genetics, Lincosamides, Macrolides/pharmacology, Mastitis, Bovine/microbiology, Microbial Sensitivity Tests, Nucleotidyltransferases/genetics, Reverse Transcriptase Polymerase Chain Reaction, Reverse Transcription, Staphylococcus aureus/drug effects/enzymology/*genetics, Transformation, Bacterial	Pathogenicity
Pathogenicity	17462772	Specific Bifidobacterium strains isolated from elderly subjects inhibit growth of Staphylococcus aureus.	Lahtinen SJ, Jalonen L, Ouwehand AC, Salminen SJ	Int J Food Microbiol	10.1016/j.ijfoodmicro.2007.02.023	2007	Aged, 80 and over, Antibiosis/physiology, Bifidobacterium/physiology, Colony Count, Microbial, Escherichia coli K12/growth & development, Gastrointestinal Tract/microbiology, Humans, Hydrogen Peroxide/metabolism, Luminescence, Salmonella typhimurium/growth & development, Staphylococcus aureus/growth & development	Metabolism
Metabolism	17620379	Role of a qnr-like gene in the intrinsic resistance of Enterococcus faecalis to fluoroquinolones.	Arsene S, Leclercq R	Antimicrob Agents Chemother	10.1128/AAC.00274-07	2007	Amino Acid Sequence, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/metabolism, Culture Media, DNA Gyrase/metabolism, Drug Resistance, Bacterial/genetics, Enterococcus faecalis/drug effects/genetics, Fluoroquinolones/pharmacology, Gene Expression Regulation, Bacterial/genetics, Genes, Bacterial, Microbial Sensitivity Tests, Molecular Sequence Data, Reverse Transcriptase Polymerase Chain Reaction	Cultivation
Pathogenicity	17666795	Transduction of the plasmid encoding antiseptic resistance gene qacB in Staphylococcus aureus.	Nakaminami H, Noguchi N, Nishijima S, Kurokawa I, So H, Sasatsu M	Biol Pharm Bull	10.1248/bpb.30.1412	2007	Bacterial Proteins/genetics, Bacteriophage Typing, Blotting, Southern, Conjugation, Genetic, DNA, Bacterial/genetics, Drug Resistance, Bacterial/genetics, Humans, Membrane Transport Proteins/genetics, Methicillin Resistance/genetics, Plasmids/genetics, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcal Infections/microbiology, Staphylococcus aureus/genetics, Transduction, Genetic
Pathogenicity	17714489	Role of hypermutability on bacterial fitness and emergence of resistance in experimental osteomyelitis due to Staphylococcus aureus.	Daurel C, Prunier AL, Chau F, Garry L, Leclercq R, Fantin B	FEMS Immunol Med Microbiol	10.1111/j.1574-695X.2007.00310.x	2007	Adenosine Triphosphatases/genetics, Animals, Bacterial Proteins/genetics, Bone and Bones/microbiology, Colony Count, Microbial, Drug Resistance, Bacterial/genetics, Gene Deletion, Microbial Sensitivity Tests, Mutagenesis, Insertional, Osteomyelitis/drug therapy/microbiology, Rats, Rifampin/therapeutic use, Staphylococcal Infections/drug therapy/microbiology, Staphylococcus aureus/drug effects/genetics/*physiology, Survival Analysis
Pathogenicity	18047789	Detection of antistaphylococcal and toxic compounds by biological assay systems developed with a reporter Staphylococcus aureus strain harboring a heat inducible promoter - lacZ transcriptional fusion.	Chanda PK, Ganguly T, Das M, Lee CY, Luong TT, Sau S	J Biochem Mol Biol	10.5483/bmbrep.2007.40.6.936	2007	Anti-Bacterial Agents/pharmacology, Arsenates/pharmacology, Base Sequence, Biological Assay/methods, Chaperonin 10/genetics, Chaperonin 60/genetics, DNA Primers/genetics, Gene Fusion, Genes, Bacterial/drug effects, Genes, Reporter, Hot Temperature, Hydrogen Peroxide/pharmacology, Lac Operon, Microbial Sensitivity Tests/methods, Operon, Promoter Regions, Genetic/drug effects, Staphylococcus aureus/drug effects/*genetics	Stress
Transcriptome	18077631	Differences in potential for selection of clindamycin-resistant mutants between inducible erm(A) and erm(C) Staphylococcus aureus genes.	Daurel C, Huet C, Dhalluin A, Bes M, Etienne J, Leclercq R	J Clin Microbiol	10.1128/JCM.01925-07	2007	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Clindamycin/pharmacology, DNA, Bacterial/genetics, Drug Resistance, Bacterial/genetics, Macrolides/pharmacology, Methyltransferases/genetics, Mutation, Selection, Genetic, Sequence Analysis, DNA, Staphylococcus aureus/drug effects/genetics, Streptogramin Group B/pharmacology	Pathogenicity
Enzymology	18510563	Two thermostable nucleases coexisted in Staphylococcus aureus: evidence from mutagenesis and in vitro expression.	Tang J, Zhou R, Shi X, Kang M, Wang H, Chen H	FEMS Microbiol Lett	10.1111/j.1574-6968.2008.01194.x	2008	Bacterial Proteins/genetics, Cloning, Molecular, DNA, Bacterial/isolation & purification, Enzyme Stability, Escherichia coli/enzymology, Gene Deletion, Gene Expression Regulation, Bacterial, Genes, Bacterial, Micrococcal Nuclease/genetics, Plasmids, RNA, Bacterial/isolation & purification, Recombinant Proteins/biosynthesis, Reverse Transcriptase Polymerase Chain Reaction, Staphylococcus aureus/enzymology/genetics, Transformation, Bacterial	Phylogeny
Pathogenicity	18571379	Frequencies of resistance to Melaleuca alternifolia (tea tree) oil and rifampicin in Staphylococcus aureus, Staphylococcus epidermidis and Enterococcus faecalis.	Hammer KA, Carson CF, Riley TV	Int J Antimicrob Agents	10.1016/j.ijantimicag.2008.03.013	2008	Anti-Bacterial Agents/pharmacology, Drug Resistance, Bacterial/genetics, Enterococcus faecalis/drug effects/genetics, Gram-Positive Cocci/drug effects/genetics, Humans, Melaleuca/chemistry, Microbial Sensitivity Tests, Mutation, Rifampin/pharmacology, Staphylococcus aureus/drug effects/genetics, Staphylococcus epidermidis/drug effects/genetics, Tea Tree Oil/*pharmacology
Pathogenicity	18638536	Antibacterial, antioxidant and fibroblast growth stimulation of aqueous extracts of Ficus asperifolia Miq. and Gossypium arboreum L., wound-healing plants of Ghana.	Annan K, Houghton PJ	J Ethnopharmacol	10.1016/j.jep.2008.06.017	2008	Anti-Bacterial Agents/administration & dosage/isolation & purification/pharmacology, Antioxidants/administration & dosage/isolation & purification/pharmacology, Cell Line, Dose-Response Relationship, Drug, Fibroblasts/drug effects/metabolism, Ficus/chemistry, Ghana, Gossypium/chemistry, Humans, Hydrogen Peroxide/toxicity, Medicine, African Traditional, Oxidative Stress/drug effects, Plant Extracts/administration & dosage/pharmacology, Plant Leaves, Wound Healing/drug effects	Enzymology
Metabolism	18803257	Antibiotics, arsenate and H2O2 induce the promoter of Staphylococcus aureus cspC gene more strongly than cold.	Chanda PK, Mondal R, Sau K, Sau S	J Basic Microbiol	10.1002/jobm.200800065	2009	Amino Acid Sequence, Anti-Bacterial Agents/pharmacology, Arsenates/pharmacology, Bacterial Proteins/genetics/metabolism, Cloning, Molecular, Cold Temperature, Gene Expression Regulation, Bacterial, Heat-Shock Proteins/genetics/metabolism, Hydrogen Peroxide/pharmacology, Molecular Sequence Data, Promoter Regions, Genetic/drug effects, Sequence Alignment, Staphylococcus aureus/drug effects/*genetics/metabolism, beta-Galactosidase/genetics/metabolism	Enzymology
Enzymology	19304835	Inactivation of the SauI type I restriction-modification system is not sufficient to generate Staphylococcus aureus strains capable of efficiently accepting foreign DNA.	Veiga H, Pinho MG	Appl Environ Microbiol	10.1128/AEM.01862-08	2009	DNA Restriction-Modification Enzymes/genetics/metabolism, DNA, Bacterial/metabolism, Gene Deletion, Gene Transfer, Horizontal, Staphylococcus aureus/enzymology/genetics, *Transformation, Bacterial	Metabolism
Pathogenicity	19528208	Inhibition of Staphylococcus epidermidis biofilm formation by rabbit polyclonal antibodies against the SesC protein.	Shahrooei M, Hira V, Stijlemans B, Merckx R, Hermans PW, Van Eldere J	Infect Immun	10.1128/IAI.01464-08	2009	Animals, Antibodies, Bacterial/pharmacology, Bacterial Proteins/immunology/physiology, Biofilms, Fibrinogen/metabolism, Humans, Rabbits, Rats, Rats, Inbred F344, Staphylococcus epidermidis/physiology	Metabolism
Pathogenicity	20100878	Activity of linezolid in an in vitro pharmacokinetic-pharmacodynamic model using different dosages and Staphylococcus aureus and Enterococcus faecalis strains with and without a hypermutator phenotype.	Ba BB, Arpin C, Bikie Bi Nso B, Dubois V, Saux MC, Quentin C	Antimicrob Agents Chemother	10.1128/AAC.01022-09	2010	Acetamides/administration & dosage/pharmacokinetics/pharmacology, Anti-Bacterial Agents/administration & dosage/pharmacokinetics/pharmacology, Base Sequence, DNA Primers/genetics, Dose-Response Relationship, Drug, Drug Resistance, Bacterial/genetics, Enterococcus faecalis/drug effects/genetics, Humans, In Vitro Techniques, Linezolid, Microbial Sensitivity Tests, Models, Biological, Oxazolidinones/administration & dosage/pharmacokinetics/pharmacology, Phenotype, Point Mutation, RNA, Bacterial/genetics, RNA, Ribosomal, 23S/genetics, Species Specificity, Staphylococcus aureus/drug effects/genetics	Phenotype
Metabolism	20185825	Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM.	Xia G, Maier L, Sanchez-Carballo P, Li M, Otto M, Holst O, Peschel A	J Biol Chem	10.1074/jbc.M109.096172	2010	Acetylglucosamine/chemistry/genetics/metabolism, Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/metabolism, Cell Wall/chemistry/enzymology/genetics, DNA Transposable Elements/genetics, Gene Knockdown Techniques, Glycosylation, Glycosyltransferases/chemistry/genetics/metabolism, Magnetic Resonance Spectroscopy, Mutation, Polysaccharides/chemistry/genetics/metabolism, Recombinant Proteins/chemistry/genetics/metabolism, Sequence Deletion, Staphylococcus aureus/enzymology/genetics, Teichoic Acids/*biosynthesis/chemistry/genetics	Enzymology
Pathogenicity	20585119	Cloning and occurrence of czrC, a gene conferring cadmium and zinc resistance in methicillin-resistant Staphylococcus aureus CC398 isolates.	Cavaco LM, Hasman H, Stegger M, Andersen PS, Skov R, Fluit AC, Ito T, Aarestrup FM	Antimicrob Agents Chemother	10.1128/AAC.00058-10	2010	Acetates/pharmacology, Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/physiology, Cadmium/pharmacology, Chlorides/pharmacology, Humans, Methicillin Resistance/genetics, Microbial Sensitivity Tests, Staphylococcus aureus/drug effects/genetics, Swine, Zinc Compounds/*pharmacology	Enzymology
Metabolism	20937760	Characterization of a Staphylococcus aureus surface virulence factor that promotes resistance to oxidative killing and infectious endocarditis.	Malachowa N, Kohler PL, Schlievert PM, Chuang ON, Dunny GM, Kobayashi SD, Miedzobrodzki J, Bohach GA, Seo KS	Infect Immun	10.1128/IAI.00736-10	2010	Animals, Bacterial Proteins/genetics/metabolism, Computational Biology, Endocarditis, Bacterial/microbiology, Gene Deletion, Gene Expression Regulation, Bacterial/physiology, Humans, Neutrophils/physiology, Oxidative Stress, Polymorphism, Restriction Fragment Length, Rabbits, Staphylococcus aureus/metabolism, Virulence Factors/chemistry/genetics/metabolism	Pathogenicity
Metabolism	21049039	Duckweed (Lemna minor) as a model plant system for the study of human microbial pathogenesis.	Zhang Y, Hu Y, Yang B, Ma F, Lu P, Li L, Wan C, Rayner S, Chen S	PLoS One	10.1371/journal.pone.0013527	2010	Bacterial Infections/metabolism/microbiology, Humans, Plants/metabolism, Pseudomonas aeruginosa/growth & development/isolation & purification, Staphylococcus aureus/growth & development/isolation & purification	Pathogenicity
Metabolism	21393142	The minor groove-binding agent ELB-21 forms multiple interstrand and intrastrand covalent cross-links with duplex DNA and displays potent bactericidal activity against methicillin-resistant Staphylococcus aureus.	Rosado H, Rahman KM, Feuerbaum EA, Hinds J, Thurston DE, Taylor PW	J Antimicrob Chemother	10.1093/jac/dkr044	2011	Anti-Bacterial Agents/metabolism/pharmacology, Benzodiazepines/metabolism/pharmacology, Binding Sites, DNA/metabolism, DNA Adducts/metabolism/pharmacology, DNA Repair/drug effects, Gene Expression Profiling, Gene Expression Regulation, Bacterial/drug effects, Methicillin-Resistant Staphylococcus aureus/drug effects, Microarray Analysis, Microbial Viability/drug effects, Protein Binding, Pyrroles/metabolism/*pharmacology	Pathogenicity
Enzymology	21808542	Wound healing properties and kill kinetics of Clerodendron splendens G. Don, a Ghanaian wound healing plant.	Gbedema SY, Emelia K, Francis A, Kofi A, Eric W	Pharmacognosy Res	10.4103/0974-8490.62948	2010
Metabolism	21880144	Lysis-deficient phages as novel therapeutic agents for controlling bacterial infection.	Paul VD, Sundarrajan S, Rajagopalan SS, Hariharan S, Kempashanaiah N, Padmanabhan S, Sriram B, Ramachandran J	BMC Microbiol	10.1186/1471-2180-11-195	2011	Animals, Biological Therapy, Endopeptidases/genetics/metabolism, Humans, Male, Mice, Staphylococcal Infections/microbiology/therapy, Staphylococcus Phages/enzymology/genetics/physiology, Staphylococcus aureus/physiology/virology, Viral Proteins/genetics/metabolism, Virus Release	Pathogenicity
Metabolism	22102735	Formylated peptides are important virulence factors in Staphylococcus aureus arthritis in mice.	Gjertsson I, Jonsson IM, Peschel A, Tarkowski A, Lindholm C	J Infect Dis	10.1093/infdis/jir713	2011	Animals, Arthritis, Infectious/immunology/microbiology/pathology, Chemotactic Factors/immunology, Chemotaxis, Leukocyte, Female, Hindlimb/microbiology/pathology, Hydroxymethyl and Formyl Transferases/genetics, Interleukin-6/blood, Kidney/immunology, Mice, N-Formylmethionine Leucyl-Phenylalanine/immunology, Neutrophils/immunology, Peroxidase/metabolism, Staphylococcal Infections/immunology/metabolism, Staphylococcus aureus/genetics/immunology/*pathogenicity, Synovial Membrane/enzymology/immunology, Weight Loss	Enzymology
Metabolism	22155775	Genes involved in immunity to and secretion of aureocin A53, an atypical class II bacteriocin produced by Staphylococcus aureus A53.	Nascimento Jdos S, Coelho ML, Ceotto H, Potter A, Fleming LR, Salehian Z, Nes IF, Bastos Mdo C	J Bacteriol	10.1128/JB.06203-11	2011	ATP-Binding Cassette Transporters/genetics/metabolism, Antimicrobial Cationic Peptides, Bacterial Proteins/chemistry/genetics/metabolism, Bacteriocins/chemistry/genetics/metabolism/pharmacology, Base Sequence, Escherichia coli/drug effects, Gene Expression, Genes, Bacterial, Mutation, Open Reading Frames, Operon, Peptides/genetics/immunology/metabolism/pharmacology, Sequence Analysis, DNA, Staphylococcus aureus/genetics/metabolism	Transcriptome
Pathogenicity	22178792	Direct and synergistic hemolysis caused by Staphylococcus phenol-soluble modulins: implications for diagnosis and pathogenesis.	Cheung GY, Duong AC, Otto M	Microbes Infect	10.1016/j.micinf.2011.11.013	2011	Bacterial Toxins/biosynthesis/chemistry/metabolism, Hemolysin Proteins/chemistry/metabolism, Hemolysis, Humans, Neutrophils/immunology/pathology, Sphingomyelin Phosphodiesterase/chemistry/metabolism, Staphylococcus aureus/chemistry/*pathogenicity, Staphylococcus epidermidis/chemistry/pathogenicity, Virulence	Metabolism
Metabolism	22380879	Comparative expression analysis of two thermostable nuclease genes in Staphylococcus aureus.	Hu Y, Xie Y, Tang J, Shi X	Foodborne Pathog Dis	10.1089/fpd.2011.1033	2012	Bacterial Proteins/chemistry/genetics/metabolism, Cell Proliferation, Enzyme Stability, Gene Expression Regulation, Bacterial, Genetic Markers, Isoenzymes/chemistry/genetics/metabolism, Micrococcal Nuclease/chemistry/genetics/metabolism, Mutation, RNA, Messenger/metabolism, Real-Time Polymerase Chain Reaction, Reverse Transcriptase Polymerase Chain Reaction, Species Specificity, Staphylococcus aureus/genetics/growth & development/*metabolism	Enzymology
Metabolism	22685284	The extracytoplasmic function sigma factor sigmaS protects against both intracellular and extracytoplasmic stresses in Staphylococcus aureus.	Miller HK, Carroll RK, Burda WN, Krute CN, Davenport JE, Shaw LN	J Bacteriol	10.1128/JB.00484-12	2012	Animals, Anti-Bacterial Agents/metabolism, Bacterial Proteins/metabolism, Cell Line, Cell Wall/drug effects, DNA, Bacterial/drug effects, Gene Expression Profiling, Gene Expression Regulation, Bacterial, Macrophages/immunology/microbiology, Mice, Microbial Viability, Promoter Regions, Genetic, Sigma Factor/metabolism, Staphylococcus aureus/genetics/metabolism/physiology, *Stress, Physiological	Pathogenicity
Pathogenicity	22982124	Synthesis and antimicrobial evaluation of L-phenylalanine-derived C5-substituted rhodanine and chalcone derivatives containing thiobarbituric acid or 2-thioxo-4-thiazolidinone.	Jin X, Zheng CJ, Song MX, Wu Y, Sun LP, Li YJ, Yu LJ, Piao HR	Eur J Med Chem	10.1016/j.ejmech.2012.08.026	2012	Anti-Bacterial Agents/chemical synthesis/chemistry/pharmacology, Chalcone/chemical synthesis/chemistry/pharmacology, Dose-Response Relationship, Drug, Microbial Sensitivity Tests, Molecular Structure, Phenylalanine/chemistry, Rhodanine/chemical synthesis/chemistry/pharmacology, Staphylococcus aureus/drug effects, Structure-Activity Relationship, Thiazolidines/chemistry, Thiobarbiturates/chemistry
Enzymology	23386262	Detection and new genetic environment of the pleuromutilin-lincosamide-streptogramin A resistance gene lsa(E) in methicillin-resistant Staphylococcus aureus of swine origin.	Li B, Wendlandt S, Yao J, Liu Y, Zhang Q, Shi Z, Wei J, Shao D, Schwarz S, Wang S, Ma Z	J Antimicrob Chemother	10.1093/jac/dkt015	2013	Animals, Anti-Bacterial Agents/pharmacology, China, Cloning, Molecular, DNA, Bacterial/genetics, Diterpenes/pharmacology, Drug Resistance, Bacterial/genetics, Enterococcus faecalis/drug effects, Lincosamides/pharmacology, Methicillin-Resistant Staphylococcus aureus/genetics, Microbial Sensitivity Tests, Multilocus Sequence Typing, Plasmids/genetics, Polycyclic Compounds, Staphylococcal Infections/drug therapy/microbiology/veterinary, Streptogramin A/pharmacology, Swine, Swine Diseases/drug therapy/microbiology, Transformation, Bacterial	Pathogenicity
Metabolism	23541215	Synergistic effects of diosmetin with erythromycin against ABC transporter over-expressed methicillin-resistant Staphylococcus aureus (MRSA) RN4220/pUL5054 and inhibition of MRSA pyruvate kinase.	Chan BC, Ip M, Gong H, Lui SL, See RH, Jolivalt C, Fung KP, Leung PC, Reiner NE, Lau CB	Phytomedicine	10.1016/j.phymed.2013.02.007	2013	ATP-Binding Cassette Transporters/metabolism, Adenosine Triphosphate/metabolism, Anti-Bacterial Agents/pharmacology, Diosmin/pharmacology, Dose-Response Relationship, Drug, Drug Synergism, Erythromycin/pharmacology, Flavonoids/pharmacology, Methicillin-Resistant Staphylococcus aureus/drug effects/metabolism, Microbial Sensitivity Tests, Pyruvate Kinase/antagonists & inhibitors	Pathogenicity
Enzymology	23555002	Stably luminescent Staphylococcus aureus clinical strains for use in bioluminescent imaging.	Plaut RD, Mocca CP, Prabhakara R, Merkel TJ, Stibitz S	PLoS One	10.1371/journal.pone.0059232	2013	Animals, Bacteriophages/genetics, Chromosomes, Bacterial/genetics, Electroporation, Founder Effect, Gene Transfer Techniques, Injections, Intravenous, Luminescence, Luminescent Measurements, Mice, Operon, Photorhabdus/chemistry/genetics, Plasmids, Staphylococcal Infections/microbiology/mortality, Staphylococcus aureus/genetics/isolation & purification/ultrastructure, Survival Analysis	Phylogeny
Pathogenicity	23629701	Novel erm(T)-carrying multiresistance plasmids from porcine and human isolates of methicillin-resistant Staphylococcus aureus ST398 that also harbor cadmium and copper resistance determinants.	Gomez-Sanz E, Kadlec K, Fessler AT, Zarazaga M, Torres C, Schwarz S	Antimicrob Agents Chemother	10.1128/AAC.00171-13	2013	Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Base Sequence, Cadmium/pharmacology, Copper/pharmacology, Drug Resistance, Multiple, Bacterial/genetics, Humans, Kanamycin/pharmacology, Membrane Proteins/genetics, Methicillin-Resistant Staphylococcus aureus/enzymology/genetics/isolation & purification, Methyltransferases/genetics, Microbial Sensitivity Tests, Molecular Sequence Data, Oxidoreductases/genetics, Plasmids/drug effects/genetics, Sequence Alignment, Sequence Analysis, DNA, Swine, Tetracycline Resistance/genetics, Tetracyclines/pharmacology, Trimethoprim Resistance/genetics	Enzymology
Enzymology	23639984	Prevalence of fusB in Staphylococcus aureus clinical isolates.	Huang J, Ye M, Ding H, Guo Q, Ding B, Wang M	J Med Microbiol	10.1099/jmm.0.058305-0	2013	Adult, Aged, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, China/epidemiology, Drug Resistance, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Fusidic Acid/pharmacology, Humans, Male, Microbial Sensitivity Tests, Multilocus Sequence Typing, Mutation, Plasmids/genetics, Polymerase Chain Reaction, Prevalence, Sequence Analysis, DNA, Staphylococcal Infections/epidemiology/microbiology, Staphylococcal Protein A/genetics, Staphylococcus aureus/classification/drug effects/genetics/isolation & purification, Young Adult	Pathogenicity
Genetics	24098817	Genetic variation in the Staphylococcus aureus 8325 strain lineage revealed by whole-genome sequencing.	Baek KT, Frees D, Renzoni A, Barras C, Rodriguez N, Manzano C, Kelley WL	PLoS One	10.1371/journal.pone.0077122	2013	Amino Acid Sequence, Base Sequence, Computational Biology, Genetic Variation/genetics, Genome, Bacterial/genetics, High-Throughput Nucleotide Sequencing/methods, INDEL Mutation/genetics, Molecular Sequence Data, Pedigree, Polymorphism, Single Nucleotide/genetics, Real-Time Polymerase Chain Reaction, Sequence Alignment, Sequence Analysis, DNA, Species Specificity, Staphylococcus aureus/*genetics	Transcriptome
Genetics	24324222	Identification of a novel vga(E) gene variant that confers resistance to pleuromutilins, lincosamides and streptogramin A antibiotics in staphylococci of porcine origin.	Li J, Li B, Wendlandt S, Schwarz S, Wang Y, Wu C, Ma Z, Shen J	J Antimicrob Chemother	10.1093/jac/dkt482	2013	Animals, Anti-Bacterial Agents/pharmacology, DNA, Bacterial/chemistry/genetics, Diterpenes/pharmacology, Drug Resistance, Multiple, Bacterial, Genes, Bacterial, Lincosamides/pharmacology, Microbial Sensitivity Tests, Molecular Sequence Data, Plasmids, Polycyclic Compounds, Sequence Analysis, DNA, Staphylococcus/drug effects/genetics/isolation & purification, Streptogramin A/pharmacology, Swine, Transformation, Bacterial	Transcriptome
Pathogenicity	24338874	Flavonoids from Sophora moorcroftiana and their synergistic antibacterial effects on MRSA.	Wang SY, Sun ZL, Liu T, Gibbons S, Zhang WJ, Qing M	Phytother Res	10.1002/ptr.5098	2013	Anti-Bacterial Agents/pharmacology, Drug Synergism, Flavonoids/pharmacology, Genistein/pharmacology, Methicillin-Resistant Staphylococcus aureus/drug effects, Microbial Sensitivity Tests, Molecular Structure, Plant Extracts/pharmacology, Sophora/chemistry
Enzymology	24366733	Identification of the novel lincosamide resistance gene lnu(E) truncated by ISEnfa5-cfr-ISEnfa5 insertion in Streptococcus suis: de novo synthesis and confirmation of functional activity in Staphylococcus aureus.	Zhao Q, Wendlandt S, Li H, Li J, Wu C, Shen J, Schwarz S, Wang Y	Antimicrob Agents Chemother	10.1128/AAC.02007-13	2013	Anti-Bacterial Agents/pharmacology, Base Sequence, Cloning, Molecular, Drug Resistance, Bacterial/genetics, Genes, Bacterial/genetics, INDEL Mutation/genetics, Lincosamides/pharmacology, Molecular Sequence Data, R Factors/chemical synthesis/genetics, Sequence Alignment, Staphylococcus aureus/drug effects/genetics, Streptococcus suis/drug effects/*genetics	Genetics
Pathogenicity	24641976	Synthesis and antibacterial evaluation of amino acid-antibiotic conjugates.	Ibrahim MA, Panda SS, Birs AS, Serrano JC, Gonzalez CF, Alamry KA, Katritzky AR	Bioorg Med Chem Lett	10.1016/j.bmcl.2014.01.065	2014	Amino Acids/chemistry, Anti-Bacterial Agents/chemical synthesis/chemistry/pharmacology, Bacillus subtilis/drug effects, Dose-Response Relationship, Drug, Escherichia coli/drug effects, Metronidazole/chemical synthesis/chemistry/pharmacology, Microbial Sensitivity Tests, Molecular Structure, Pseudomonas aeruginosa/drug effects, Quinolones/chemical synthesis/chemistry/pharmacology, Staphylococcus aureus/drug effects, Structure-Activity Relationship, Sulfadiazine/chemical synthesis/chemistry/*pharmacology
Phylogeny	24951306	The Staphylococcal Cassette Chromosome mec type V from Staphylococcus aureus ST398 is packaged into bacteriophage capsids.	Chlebowicz MA, Maslanova I, Kuntova L, Grundmann H, Pantucek R, Doskar J, van Dijl JM, Buist G	Int J Med Microbiol	10.1016/j.ijmm.2014.05.010	2014	Genes, Bacterial, Methicillin Resistance, Methicillin-Resistant Staphylococcus aureus/genetics/virology, Plasmids, Prophages/genetics/physiology, Staphylococcus Phages/classification/genetics, Transduction, Genetic, *Virus Assembly
Pathogenicity	25212982	Combating against methicillin-resistant Staphylococcus aureus - two fatty acids from Purslane (Portulaca oleracea L.) exhibit synergistic effects with erythromycin.	Chan BC, Han XQ, Lui SL, Wong CW, Wang TB, Cheung DW, Cheng SW, Ip M, Han SQ, Yang XS, Jolivalt C, Lau CB, Leung PC, Fung KP	J Pharm Pharmacol	10.1111/jphp.12315	2014	Anti-Bacterial Agents/pharmacology, Ciprofloxacin/pharmacology, Drug Synergism, Drug Therapy, Combination, Erythromycin/pharmacology, Gas Chromatography-Mass Spectrometry, Linoleic Acid/chemistry/pharmacology, Methicillin-Resistant Staphylococcus aureus/drug effects, Microbial Sensitivity Tests, Oleic Acid/chemistry/pharmacology, Plant Extracts/chemistry, Portulaca
Enzymology	25477024	Enhancing DNA electro-transformation efficiency on a clinical Staphylococcus capitis isolate.	Cui B, Smooker PM, Rouch DA, Deighton MA	J Microbiol Methods	10.1016/j.mimet.2014.11.012	2014	Bacteremia/microbiology, DNA Restriction-Modification Enzymes/radiation effects, DNA, Bacterial/genetics, Electroporation/methods, Genetic Vectors, Hot Temperature, Humans, Infant, Newborn, Staphylococcus/genetics/isolation & purification/radiation effects, *Transformation, Bacterial	Stress
Pathogenicity	25600843	Detection of heterogeneous vancomycin-intermediate Staphylococcus aureus isolates using a combination of delta-hemolysis assay and Etest.	Chang SC, Liu TP, Chen CJ, Lin LC, Lu JJ	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2014.12.006	2014	Algorithms, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/analysis, Bacteriological Techniques/methods, Carbon Dioxide/metabolism, Drug Tolerance, Hemolysin Proteins/analysis, Humans, Sensitivity and Specificity, Staphylococcus aureus/classification/drug effects/isolation & purification, Temperature, Time Factors, Vancomycin/pharmacology	Phylogeny
Enzymology	26015493	Complete Bypass of Restriction Systems for Major Staphylococcus aureus Lineages.	Monk IR, Tree JJ, Howden BP, Stinear TP, Foster TJ	mBio	10.1128/mBio.00308-15	2015	DNA Methylation, DNA Restriction-Modification Enzymes/genetics/metabolism, DNA, Bacterial/genetics, Escherichia coli/genetics, Genetic Vectors, Mutation, Plasmids, Staphylococcus aureus/genetics, Transformation, Bacterial	Metabolism
	26052549	The Essential WalK Histidine Kinase and WalR Regulator Differentially Mediate Autolysis of Staphylococcus aureus RN4220.	Zheng L, Yan M, Fan F, Ji Y	J Nat Sci		2015
Pathogenicity	26193939	Compounds in a particular production lot of tryptic soy broth inhibit Staphylococcus aureus cell growth.	Ishii M, Matsumoto Y, Sekimizu K	Drug Discov Ther	10.5582/ddt.2015.01030	2015	Caseins/pharmacology, Cell Proliferation/drug effects, Methicillin-Resistant Staphylococcus aureus/drug effects, Protein Hydrolysates/pharmacology, Staphylococcus aureus/*drug effects/growth & development	Biotechnology
Pathogenicity	26453316	In vitro activity of human and animal cathelicidins against livestock-associated methicillin-resistant Staphylococcus aureus.	Blodkamp S, Kadlec K, Gutsmann T, Naim HY, von Kockritz-Blickwede M, Schwarz S	Vet Microbiol	10.1016/j.vetmic.2015.09.018	2015	Animals, Anti-Bacterial Agents/pharmacology, Cathelicidins/isolation & purification/pharmacology, Cattle, Drug Resistance, Bacterial/genetics, Humans, Methicillin-Resistant Staphylococcus aureus/drug effects/genetics, Mice, Microbial Sensitivity Tests	Enzymology
Metabolism	27260167	Dissecting the regulation of bile-induced biofilm formation in Staphylococcus aureus.	Ulluwishewa D, Wang L, Pereira C, Flynn S, Cain E, Stick S, Reen FJ, Ramsay JP, O'Gara F	Microbiology (Reading)	10.1099/mic.0.000317	2016	ATP-Binding Cassette Transporters/genetics, Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Bile/metabolism, Biofilms/growth & development, Cell Wall/metabolism, Cystic Fibrosis/microbiology/pathology, DNA Transposable Elements/genetics, Humans, Lung/microbiology/pathology, Microbial Sensitivity Tests, Protein Transport/genetics, Staphylococcal Infections/microbiology, Staphylococcus aureus/drug effects/growth & development, Teichoic Acids/biosynthesis/metabolism	Pathogenicity
	27298617	Action of cholecalciferol and alpha-tocopherol on Staphylococcus aureus efflux pumps.	Tintino SR, Morais-Tintino CD, Campina FF, Pereira RL, Costa Mdo S, Braga MF, Limaverde PW, Andrade JC, Siqueira-Junior JP, Coutinho HD, Balbino VQ, Leal-Balbino TC, Ribeiro-Filho J, Quintans-Junior LJ	EXCLI J	10.17179/excli2016-277	2016
	27567890	Efficient transformation of Staphylococcus aureus using multi-pulse electroporation.	Hisatsune J, Sato'o Y, Yu L, Kutsuno S, Hayakawa Y, Sugai M	J Microbiol Methods	10.1016/j.mimet.2016.08.012	2016	DNA, Bacterial/genetics, Electric Conductivity, Electricity, Electroporation/instrumentation/methods, Genetic Techniques/instrumentation, Plasmids, Staphylococcus aureus/genetics, Temperature, Transformation, Bacterial
Pathogenicity	28088472	Cholesterol and ergosterol affect the activity of Staphylococcus aureus antibiotic efflux pumps.	Tintino SR, Oliveira-Tintino CD, Campina FF, Costa MS, Cruz RP, Pereira RL, Andrade JC, Sousa EO, Siqueira-Junior JP, Coutinho HD, Leal-Balbino TC, Balbino VQ	Microb Pathog	10.1016/j.micpath.2017.01.019	2017	Anti-Bacterial Agents/chemistry/pharmacology, Cholesterol/chemistry/pharmacology, Drug Antagonism, Ergosterol/chemistry/pharmacology, Microbial Sensitivity Tests, Staphylococcus aureus/drug effects/physiology
Pathogenicity	28365326	Inhibitory effects of flavonoids on biofilm formation by Staphylococcus aureus that overexpresses efflux protein genes.	Lopes LAA, Dos Santos Rodrigues JB, Magnani M, de Souza EL, de Siqueira-Junior JP	Microb Pathog	10.1016/j.micpath.2017.03.033	2017	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Biofilms/drug effects/growth & development, Flavonoids/administration & dosage/antagonists & inhibitors/chemistry, Gene Expression Regulation, Bacterial/genetics, Glycosylation/drug effects, Hesperidin/administration & dosage/antagonists & inhibitors/chemistry, Membrane Transport Proteins/genetics, Microbial Sensitivity Tests, Multidrug Resistance-Associated Proteins/genetics, Phloretin/administration & dosage/antagonists & inhibitors/chemistry, Phlorhizin/administration & dosage/antagonists & inhibitors/chemistry, Staphylococcus aureus/drug effects/genetics
Metabolism	28588310	The development of fluorescent protein tracing vectors for multicolor imaging of clinically isolated Staphylococcus aureus.	Kato F, Nakamura M, Sugai M	Sci Rep	10.1038/s41598-017-02930-7	2017	Bacterial Proteins/genetics/metabolism, Codon, Fluorescent Antibody Technique, Gene Expression, Genes, Reporter, Genetic Vectors/genetics, Green Fluorescent Proteins/genetics/metabolism, Molecular Imaging, Mutation, Promoter Regions, Genetic, Staphylococcal Infections/diagnosis/microbiology, Staphylococcus aureus/genetics/*metabolism	Phylogeny
Phenotype	28841421	Tannic acid affects the phenotype of Staphylococcus aureus resistant to tetracycline and erythromycin by inhibition of efflux pumps.	Tintino SR, Morais-Tintino CD, Campina FF, Costa MDS, Menezes IRA, de Matos YMLS, Calixto-Junior JT, Pereira PS, Siqueira-Junior JP, Leal-Balbino TC, Coutinho HDM, Balbino VQ	Bioorg Chem	10.1016/j.bioorg.2017.08.004	2017	Anti-Bacterial Agents/chemistry/pharmacology, Dose-Response Relationship, Drug, Drug Resistance, Bacterial/drug effects/genetics, Erythromycin/chemistry/pharmacology, Microbial Sensitivity Tests, Molecular Structure, Phenotype, Staphylococcus aureus/drug effects/genetics, Structure-Activity Relationship, Tannins/chemistry/pharmacology, Tetracycline/chemistry/pharmacology	Pathogenicity
Pathogenicity	29253342	Safe Staphylococcal Platform for the Development of Multivalent Nanoscale Vesicles against Viral Infections.	Yuan J, Yang J, Hu Z, Yang Y, Shang W, Hu Q, Zheng Y, Peng H, Zhang X, Cai X, Zhu J, Li M, Hu X, Zhou R, Rao X	Nano Lett	10.1021/acs.nanolett.7b03893	2018	Animals, Bacterial Proteins/genetics, Cell-Derived Microparticles/genetics, Dengue/prevention & control, Dengue Vaccines/administration & dosage/genetics/therapeutic use, Dengue Virus/genetics, Gene Deletion, Humans, Mice, Mice, Inbred BALB C, Recombinant Fusion Proteins/genetics, Staphylococcus aureus/genetics, Trans-Activators/genetics, Viral Envelope Proteins/genetics
	29312199	Construction of Stable Fluorescent Reporter Plasmids for Use in Staphylococcus aureus.	Rodriguez MD, Paul Z, Wood CE, Rice KC, Triplett EW	Front Microbiol	10.3389/fmicb.2017.02491	2017
Pathogenicity	29705276	Biophysical evaluation of cardiolipin content as a regulator of the membrane lytic effect of antimicrobial peptides.	Hernandez-Villa L, Manrique-Moreno M, Leidy C, Jemiola-Rzeminska M, Ortiz C, Strzalka K	Biophys Chem	10.1016/j.bpc.2018.04.001	2018	Anti-Bacterial Agents/pharmacology, Antimicrobial Cationic Peptides/pharmacology, Cardiolipins/chemistry, Cell Membrane/chemistry/drug effects, Microbial Sensitivity Tests, Staphylococcus aureus/cytology/*drug effects
Enzymology	29758246	Creation of deletion and insertion clonal complex 8 Staphylococcus aureus mutants using a common cloning vector.	Chen P, Karna SLR, Leung KP	J Microbiol Methods	10.1016/j.mimet.2018.05.008	2018	Bacterial Proteins/genetics, Biofilms, DNA, Bacterial, Electroporation/methods, Exotoxins/genetics, Genes, Bacterial/genetics, Genetic Vectors, Mutagenesis, Insertional/methods, Plasmids, Pseudomonas aeruginosa/genetics, Sequence Deletion, Staphylococcus aureus/genetics	Pathogenicity
Metabolism	30149194	Changes in resistance to and antimicrobial activity of antibiotics during in vitro human digestion.	Lee SY, Kim OY, Yoon SY, Lee DY, Hur SJ	J Glob Antimicrob Resist	10.1016/j.jgar.2018.08.017	2018	Anti-Bacterial Agents/metabolism/pharmacology, Digestion, Drug Resistance, Bacterial, Gastrointestinal Tract/metabolism/microbiology, Humans, Microbial Sensitivity Tests, Models, Biological, Ofloxacin/metabolism/pharmacology, Penicillins/metabolism/pharmacology, Staphylococcus aureus/*drug effects/growth & development, Tetracycline/metabolism/pharmacology	Pathogenicity
Enzymology	30176356	Isovalerylshikonin, a new resistance-modifying agent from Arnebia euchroma, supresses antimicrobial resistance of drug-resistant Staphylococcus aureus.	He JM, Sun SC, Sun ZL, Chen JT, Mu Q	Int J Antimicrob Agents	10.1016/j.ijantimicag.2018.08.021	2018	Animals, Anti-Bacterial Agents/administration & dosage/pharmacokinetics/pharmacology, Boraginaceae/chemistry, Drug Synergism, Mice, Microbial Sensitivity Tests, Naphthoquinones/administration & dosage/chemistry/pharmacokinetics/pharmacology, Pentanoic Acids/administration & dosage/chemistry/pharmacokinetics/pharmacology, Peritonitis/drug therapy/microbiology, Sepsis/drug therapy/microbiology, Staphylococcal Infections/drug therapy/microbiology, Staphylococcus aureus/drug effects	Pathogenicity
Metabolism	30518106	Intracellular Accumulation of Linezolid and Florfenicol in OptrA-Producing Enterococcus faecalis and Staphylococcus aureus.	Wang Y, Li X, Wang Y, Schwarz S, Shen J, Xia X	Molecules	10.3390/molecules23123195	2018	Drug Resistance, Bacterial, Enterococcus faecalis/metabolism, Linezolid/metabolism, Oxazolidinones/pharmacology, Species Specificity, Staphylococcus aureus/metabolism, Thiamphenicol/*analogs & derivatives/metabolism	Phylogeny
Pathogenicity	30538695	Characterization of the Multi-Drug Resistance Gene cfr in Methicillin-Resistant Staphylococcus aureus (MRSA) Strains Isolated From Animals and Humans in China.	Li SM, Zhou YF, Li L, Fang LX, Duan JH, Liu FR, Liang HQ, Wu YT, Gu WQ, Liao XP, Sun J, Xiong YQ, Liu YH	Front Microbiol	10.3389/fmicb.2018.02925	2018		Phylogeny
Metabolism	30942689	Use of the counter selectable marker PheS* for genome engineering in Staphylococcus aureus.	Schuster CF, Howard SA, Grundling A	Microbiology (Reading)	10.1099/mic.0.000791	2019	Bacterial Proteins/genetics/metabolism, Cloning, Molecular, Gene Knockout Techniques, Genetic Engineering, Genetic Vectors/genetics/metabolism, Genome, Bacterial, Humans, Phenylalanine-tRNA Ligase/genetics/metabolism, Plasmids/genetics/metabolism, Staphylococcal Infections/microbiology, Staphylococcus aureus/enzymology/genetics/metabolism	Enzymology
Pathogenicity	31022566	Capsaicin and gingerol analogues inhibit the growth of efflux-multidrug resistant bacteria and R-plasmids conjugal transfer.	Oyedemi BO, Kotsia EM, Stapleton PD, Gibbons S	J Ethnopharmacol	10.1016/j.jep.2019.111871	2019	Anti-Bacterial Agents/pharmacology, Capsaicin/pharmacology, Catechols/pharmacology, Drug Resistance, Multiple, Bacterial/drug effects, Fatty Alcohols/pharmacology, Microbial Sensitivity Tests, R Factors, Staphylococcus aureus/drug effects/growth & development
	31195521	Osmoadaptation by Staphylococcus aureus : Analysis of Several Strains Linked to Food Poisoning Outbreaks.	Louch HA, Eck ML, Miller KJ	J Food Prot	10.4315/0362-028X-60.2.139	1997
Pathogenicity	31231110	Molecular characterization of multi-drug resistant coagulase negative cocci in non-hospital environment.	Nwibo DD, Panthee S, Hamamoto H, Sekimizu K	Drug Discov Ther	10.5582/ddt.2019.01031	2019	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Base Composition, Coagulase/metabolism, Drug Resistance, Multiple, Bacterial, Genome Size, Microbial Sensitivity Tests, Staphylococcus capitis/drug effects/genetics/isolation & purification, Staphylococcus haemolyticus/drug effects/genetics/isolation & purification, Whole Genome Sequencing/methods	Genetics
Pathogenicity	31307989	The tva(A) Gene from Brachyspira hyodysenteriae Confers Decreased Susceptibility to Pleuromutilins and Streptogramin A in Escherichia coli.	Garcia-Martin AB, Schwendener S, Perreten V	Antimicrob Agents Chemother	10.1128/AAC.00930-19	2019	Animals, Brachyspira hyodysenteriae/drug effects/genetics, Diterpenes/pharmacology, Drug Resistance, Bacterial/genetics, Escherichia coli/drug effects/genetics, Microbial Sensitivity Tests, Polycyclic Compounds/pharmacology, Staphylococcus aureus/drug effects/genetics, Streptogramin A/*pharmacology, Swine, Swine Diseases/microbiology
Pathogenicity	31388727	Silviavirus phage MR003 displays a broad host range against methicillin-resistant Staphylococcus aureus of human origin.	Peng C, Hanawa T, Azam AH, LeBlanc C, Ung P, Matsuda T, Onishi H, Miyanaga K, Tanji Y	Appl Microbiol Biotechnol	10.1007/s00253-019-10039-2	2019	Genetic Variation, Genome, Viral, Host Specificity, Humans, Methicillin-Resistant Staphylococcus aureus/virology, Phage Therapy, Sewage/virology, Staphylococcal Infections/therapy, Staphylococcus Phages/genetics/isolation & purification/*physiology, Teichoic Acids/metabolism, Tokyo, Virus Attachment	Genetics
Metabolism	31548327	In Staphylococcus aureus, the Particulate State of the Cell Envelope Is Required for the Efficient Induction of Host Defense Responses.	Kim B, Jiang T, Bae JH, Yun HS, Jang SH, Kim JH, Kim JD, Hur JH, Shibata K, Kurokawa K, Jung Y, Peschel A, Bae T, Lee BL	Infect Immun	10.1128/IAI.00674-19	2019	Animals, Cell Wall/immunology, Chemokine CCL2/metabolism, Chemokine CXCL1/metabolism, Female, Immunity, Innate/immunology, Leukocyte L1 Antigen Complex/metabolism, Macrophages/immunology, Male, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Knockout, Monocytes/immunology, Neutrophils/immunology, Phagocytosis/immunology, Staphylococcal Infections/immunology/microbiology, Staphylococcus aureus/*immunology	Pathogenicity
	32200127	A class A beta-lactamase produced by borderline oxacillin-resistant Staphylococcus aureus hydrolyses oxacillin.	Nomura R, Nakaminami H, Takasao K, Muramatsu S, Kato Y, Wajima T, Noguchi N	J Glob Antimicrob Resist	10.1016/j.jgar.2020.03.002	2020	Anti-Bacterial Agents/pharmacology/therapeutic use, Methicillin-Resistant Staphylococcus aureus/genetics, Oxacillin/pharmacology, Staphylococcus aureus/genetics, beta-Lactamases/genetics
	32263116	Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria.	Spagnul C, Greenman J, Wainwright M, Kamil Z, Boyle RW	J Mater Chem B	10.1039/c5tb02569a	2016
Pathogenicity	32419377	Penicillin-binding protein PBP2a provides variable levels of protection toward different beta-lactams in Staphylococcus aureus RN4220.	Fergestad ME, Stamsas GA, Morales Angeles D, Salehian Z, Wasteson Y, Kjos M	Microbiologyopen	10.1002/mbo3.1057	2020	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Drug Resistance, Bacterial/genetics, Humans, Methicillin-Resistant Staphylococcus aureus/drug effects/genetics/isolation & purification, Microbial Sensitivity Tests, Microfluidics, Penicillin-Binding Proteins/genetics/metabolism, beta-Lactams/*pharmacology	Metabolism
Pathogenicity	32449250	MsrA Efflux Pump Inhibitory Activity of Piper cubeba L.f. and its Phytoconstituents against Staphylococcus aureus RN4220.	Ahirrao P, Tambat R, Chandal N, Mahey N, Kamboj A, Jain UK, Singh IP, Jachak SM, Nandanwar HS	Chem Biodivers	10.1002/cbdv.202000144	2020	Animals, Bacterial Proteins/antagonists & inhibitors, Carbon-13 Magnetic Resonance Spectroscopy, Cell Line, Chromatography, High Pressure Liquid, Humans, Lignans/pharmacology, Mass Spectrometry, Membrane Transport Proteins/drug effects, Mice, Microbial Sensitivity Tests, Piper/chemistry, Plant Extracts/pharmacology, Proton Magnetic Resonance Spectroscopy, Staphylococcus aureus/drug effects
Genetics	32607281	Whole-genome sequence analyses of Glaesserella parasuis isolates reveals extensive genomic variation and diverse antibiotic resistance determinants.	Wan X, Li X, Osmundson T, Li C, Yan H	PeerJ	10.7717/peerj.9293	2020		Transcriptome
	32983054	The Role of Amino Acid Substitution in HepT Toward Menaquinone Isoprenoid Chain Length Definition and Lysocin E Sensitivity in Staphylococcus aureus.	Panthee S, Paudel A, Hamamoto H, Uhlemann AC, Sekimizu K	Front Microbiol	10.3389/fmicb.2020.02076	2020
Pathogenicity	33127513	Effect of estragole over the RN4220 Staphylococcus aureus strain and its toxicity in Drosophila melanogaster.	Bezerra AH, Bezerra SR, Macedo NS, de Sousa Silveira Z, Dos Santos Barbosa CR, de Freitas TS, Muniz DF, de Sousa Junior DL, Junior JPS, Donato IA, Coutinho HDM, da Cunha FAB	Life Sci	10.1016/j.lfs.2020.118675	2020	Allylbenzene Derivatives, Animals, Anisoles/administration & dosage/toxicity, Anti-Bacterial Agents/administration & dosage/toxicity, Dose-Response Relationship, Drug, Drosophila melanogaster, Drug Resistance, Multiple, Bacterial/drug effects/physiology, Erythromycin/administration & dosage, Flavoring Agents/administration & dosage/toxicity, Microbial Sensitivity Tests/methods, Staphylococcus aureus/drug effects/physiology
Pathogenicity	33635515	Inhibition of Staphylococcus aureus TetK and MsrA efflux pumps by hydroxyamines derived from lapachol and norlachol.	Figueredo FG, Parente RELT, Cavalcante-Figueredo MR, Figueiredo JG, da Silva RLP, Ferreira Matias EF, Silva TMS, Camara CA, de Morais Oliveira-Tintino CD, Tintino SR, Coutinho HDM, Fonteles MMF	J Bioenerg Biomembr	10.1007/s10863-021-09885-5	2021	Anti-Bacterial Agents/pharmacology/therapeutic use, Naphthoquinones/pharmacology/therapeutic use, Staphylococcus aureus/*drug effects
Metabolism	33987904	N-terminal acetylation of antimicrobial peptide L163 improves its stability against protease degradation.	Li D, Yang Y, Li R, Huang L, Wang Z, Deng Q, Dong S	J Pept Sci	10.1002/psc.3337	2021	Acetylation, Anti-Bacterial Agents/pharmacology, Antimicrobial Peptides, Microbial Sensitivity Tests, Peptide Hydrolases, Staphylococcus aureus
Enzymology	33997506	Multiplexed detection and differentiation of bacterial enzymes and bacteria by color-encoded sensor hydrogels.	Jia Z, Muller M, Le Gall T, Riool M, Muller M, Zaat SAJ, Montier T, Schonherr H	Bioact Mater	10.1016/j.bioactmat.2021.04.022	2021
	34001856	ROS induces NETosis by oxidizing DNA and initiating DNA repair.	Azzouz D, Khan MA, Palaniyar N	Cell Death Discov	10.1038/s41420-021-00491-3	2021
	34069037	Identification of the Multiresistance Gene poxtA in Oxazolidinone-Susceptible Staphylococcus haemolyticus and Staphylococcus saprophyticus of Pig and Feed Origins.	Chen L, Hu JX, Liu C, Liu J, Ma ZB, Tang ZY, Li YF, Zeng ZL	Pathogens	10.3390/pathogens10050601	2021
	34575478	Hypericin and Pheophorbide a Mediated Photodynamic Therapy Fighting MRSA Wound Infections: A Translational Study from In Vitro to In Vivo.	Chan BCL, Dharmaratne P, Wang B, Lau KM, Lee CC, Cheung DWS, Chan JYW, Yue GGL, Lau CBS, Wong CK, Fung KP, Ip M	Pharmaceutics	10.3390/pharmaceutics13091399	2021
Metabolism	34878306	Novel Tet(L) Efflux Pump Variants Conferring Resistance to Tigecycline and Eravacycline in Staphylococcus Spp.	Wang N, Li D, Schwarz S, Qin S, Yao H, Du XD	Microbiol Spectr	10.1128/Spectrum.01310-21	2021	Animals, Anti-Bacterial Agents/metabolism/pharmacology, Bacterial Proteins/genetics/metabolism, Disease Models, Animal, Drug Resistance, Multiple, Bacterial/genetics, Female, Genome, Bacterial/genetics, Mice, Mice, Inbred BALB C, Microbial Sensitivity Tests, Multigene Family/genetics, Pneumonia/microbiology, Protein Transport/genetics, Sepsis/microbiology, Staphylococcal Infections/drug therapy, Staphylococcus aureus/drug effects/genetics/metabolism, Swine, Swine Diseases/microbiology, Tetracyclines/metabolism/pharmacology, Tigecycline/metabolism/pharmacology, Whole Genome Sequencing	Genetics
	35625264	Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Staphylococcus aureus from Diabetic Foot Ulcer Infections.	Oliveira D, Borges A, Saavedra MJ, Borges F, Simoes M	Antibiotics (Basel)	10.3390/antibiotics11050620	2022
Pathogenicity	35711812	A Small Multihost Plasmid Carrying erm(T) Identified in Enterococcus faecalis.	Li XY, Yu R, Xu C, Shang Y, Li D, Du XD	Front Vet Sci	10.3389/fvets.2022.850466	2022
Pathogenicity	35745011	Antibacterial and Oxidative Stress-Protective Effects of Five Monoterpenes from Softwood.	Muilu-Makela R, Aapola U, Tienaho J, Uusitalo H, Sarjala T	Molecules	10.3390/molecules27123891	2022	Anti-Bacterial Agents/pharmacology, Antioxidants/pharmacology, Escherichia coli, Humans, Hydrogen Peroxide/pharmacology, Microbial Sensitivity Tests, Monoterpenes/pharmacology, Oils, Volatile/pharmacology, Oxidative Stress	Stress
Genetics	35880893	Bioinformatic Analysis of a Set of 14 Temperate Bacteriophages Isolated from Staphylococcus aureus Strains Highlights Their Massive Genetic Diversity.	Suarez CA, Carrasco ST, Brandolisio FNA, Abatangelo V, Boncompain CA, Peresutti-Bacci N, Morbidoni HR	Microbiol Spectr	10.1128/spectrum.00334-22	2022	Animals, Bacteriophages/genetics, Cattle, Computational Biology, Genetic Variation, Genome, Viral, Humans, Staphylococcal Infections/veterinary, Staphylococcus aureus/genetics	Pathogenicity
Pathogenicity	36037346	Breaking down antibiotic resistance in methicillin-resistant Staphylococcus aureus: Combining antimicrobial photodynamic and antibiotic treatments.	Willis JA, Cheburkanov V, Chen S, Soares JM, Kassab G, Blanco KC, Bagnato VS, de Figueiredo P, Yakovlev VV	Proc Natl Acad Sci U S A	10.1073/pnas.2208378119	2022	Anti-Bacterial Agents/pharmacology, Drug Resistance, Microbial/drug effects/radiation effects, Humans, Methicillin-Resistant Staphylococcus aureus/drug effects/radiation effects, *Photochemotherapy, Photosensitizing Agents/pharmacology, Reactive Oxygen Species/pharmacology
Genetics	36387480	Hybrid assembly using long reads resolves repeats and completes the genome sequence of a laboratory strain of Staphylococcus aureus subsp. aureus RN4220.	Panthee S, Hamamoto H, Paudel A, Kaito C, Suzuki Y, Sekimizu K	Heliyon	10.1016/j.heliyon.2022.e11376	2022
	36465119	An 11-year linezolid-resistant Staphylococcus capitis clone dissemination with a similar cfr-carrying plasmid in China.	Shen W, Chen J, Zhang R, Cai J	iScience	10.1016/j.isci.2022.105644	2022
Biotechnology	36472430	Horizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness.	Krauss S, Harbig TA, Rapp J, Schaefle T, Franz-Wachtel M, Reetz L, Elsherbini AMA, Macek B, Grond S, Link H, Nieselt K, Krismer B, Peschel A, Heilbronner S	Microbiol Spectr	10.1128/spectrum.03176-22	2022

Reference

@id	authors	catalogue	doi/url	title
18922	Curators of the DSMZ	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 26309)	https://www.dsmz.de/collection/catalogue/details/culture/DSM-26309
20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.		10.1099/ijsem.0.004332	List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann		https://diaspora-project.de/progress.html#genomes	Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information)
68375				Automatically annotated from API ID32STA
87514	Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.		10.60712/SI-ID405493.1	StrainInfo: A central database for resolving microbial strain identifiers

General

NCBI tax id

strain history

Name and taxonomic classification

LPSN

synonyms

Culture and growth conditions

culture medium

culture temp

Physiology and metabolism

metabolite utilization

antibiotic resistance

metabolite production

metabolite tests

enzymes

API ID32STA

Isolation, sampling and environmental information

isolation

isolation source categories

Safety information

risk assessment

Sequence information

Genome sequences

Genome-based predictions

predictions

External links

straininfo link

literature

Reference