Archive BacDiveID:10.13145/bacdive5300.20230509.8.1

Strain identifier

BacDive ID: 5300

Type strain:

Species: Enterococcus faecium

Strain history: <- K. Huppertz, GENARS; Van A <- Merlin Diagnostika GmbH;

NCBI tax ID(s): 1352 (species)

For citation purpose refer to the digital object identifier (doi) of the current version.

General

@ref: 6710

BacDive-ID: 5300

DSM-Number: 17050

keywords: Bacteria, microaerophile, mesophilic, antibiotic resistance

description: Enterococcus faecium DSM 17050 is a microaerophile, mesophilic bacterium that has multiple antibiotic resistances and was isolated from clinical sample.

NCBI tax id

NCBI tax id: 1352
Matching level: species

strain history

@ref: 6710
history: <- K. Huppertz, GENARS; Van A <- Merlin Diagnostika GmbH;

doi: 10.13145/bacdive5300.20230509.8.1

Name and taxonomic classification

LPSN

@ref: 20215
description: domain/bacteria
keyword: phylum/bacillota
domain: Bacteria
phylum: Bacillota
class: Bacilli
order: Lactobacillales
family: Enterococcaceae
genus: Enterococcus
species: Enterococcus faecium
full scientific name: Enterococcus faecium (Orla-Jensen 1919) Schleifer and Kilpper-Bälz 1984
synonyms
- @ref: 20215
- synonym: Streptococcus faecium

@ref: 6710

domain: Bacteria

phylum: Firmicutes

class: Bacilli

order: Lactobacillales

family: Enterococcaceae

genus: Enterococcus

species: Enterococcus faecium

full scientific name: Enterococcus faecium (Orla-Jensen 1919) Schleifer and Kilpper-Bälz 1984

type strain: no

Morphology

colony morphology

@ref: 6710
type of hemolysis: alpha
hemolysis ability: 1
incubation period: 1-2 days

Culture and growth conditions

culture medium

@ref	name	growth	link	composition
6710	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	yes	https://mediadive.dsmz.de/medium/693	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
6710	TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)	yes	https://mediadive.dsmz.de/medium/92	Name: TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Yeast extract 3.0 g/l Distilled water

culture temp

@ref: 6710
growth: positive
type: growth
temperature: 37
range: mesophilic

Physiology and metabolism

oxygen tolerance

@ref: 6710
oxygen tolerance: microaerophile

antibiogram

@ref	medium	incubation temperature	oxygen condition	ampicillin	mezlocillin	imipenem	tetracycline	chloramphenicol	gentamycin	amikacin	ofloxacin	norfloxacin	nitrofurantoin	bacitracin	polymyxin b	kanamycin	neomycin	doxycycline	ceftriaxone	clindamycin	fosfomycin	moxifloxacin	linezolid	nystatin	quinupristin/dalfopristin	teicoplanin	piperacillin/tazobactam
6710	Mueller-Hinton Agar	37	microaerophil	12	10-12	0	10-12	26	12	12-14	20	22	8-10	0	0	10	14	20	0	0	20	24-26	32	0	18	8	8
6710	Mueller-Hinton Agar			10	10	8	10-12	24	14-16	16	20	24	8	8	8	22	14-16	18-20	0	0	18-20	26	28	0	20	10	6
6710	Mueller-Hinton Agar	37		0	8	20	8	0	0	0	0	16	6	0	0	0	10	12	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.	n.d.
6710	Mueller-Hinton Agar	37	microaerophil	10	10	0	10	22-24	12	14	18	20	6-8	0	0	10	14	16-18	0	0	18	22	30	0	18	8-10	6
6710	Mueller-Hinton Agar	37	microaerophil	10	10	0	10	22-24	12	14	18	20	6-8	0	0	10	14	16-18	0	0	18	22	30	0	18	8-10	6

observation

@ref: 6710
observation: Vancomycin resistant

metabolite utilization

@ref	Chebi-ID	metabolite	utilization activity	kind of utilization tested
68381	29016	arginine	+	hydrolysis
68381	16988	D-ribose	+	builds acid from
68381	16899	D-mannitol	+	builds acid from
68381	30911	sorbitol	-	builds acid from
68381	17716	lactose	+	builds acid from
68381	27082	trehalose	+	builds acid from
68381	17992	sucrose	-	builds acid from
68381	30849	L-arabinose	+	builds acid from
68381	18333	D-arabitol	-	builds acid from
68381	28087	glycogen	-	builds acid from
68381	27941	pullulan	-	builds acid from
68381	17306	maltose	+	builds acid from
68381	6731	melezitose	-	builds acid from
68381	320055	methyl beta-D-glucopyranoside	+	builds acid from
68381	16443	D-tagatose	-	builds acid from

metabolite production

@ref: 68381
Chebi-ID: 15688
metabolite: acetoin
production: yes

metabolite tests

@ref: 68381
Chebi-ID: 15688
metabolite: acetoin
voges-proskauer-test: +

enzymes

@ref	value	activity	ec
6710	catalase	-	1.11.1.6
6710	cytochrome-c oxidase	-	1.9.3.1
68381	pyrrolidonyl arylamidase	+	3.4.19.3
68381	beta-galactosidase	+	3.2.1.23
68381	Alanyl-Phenylalanyl-Proline arylamidase	-
68381	alkaline phosphatase	-	3.1.3.1
68381	beta-glucuronidase	-	3.2.1.31
68381	beta-glucosidase	+	3.2.1.21
68381	arginine dihydrolase	+	3.5.3.6

API rID32STR

@ref	ADH Arg	beta GLU	beta GAR	beta GUR	alpha GAL	PAL	RIB	MAN	SOR	LAC	TRE	RAF	SAC	LARA	DARL	CDEX	VP	APPA	beta GAL	PyrA	beta NAG	GTA	HIP	GLYG	PUL	MAL	MEL	MLZ	Mbeta DG	TAG	beta MAN	URE
6710	+	+	-	-	-	-	+	+	-	+	+	-	-	+	-	+	+	-	+	+	+	+	-	-	-	+	-	-	+	-	-	-
6710	+	+	+	-	-	-	+	+	-	+	+	-	-	+	-	+	+	-	+	+	+	+	+	-	-	+	-	-	+	-	-	-
6710	+	+	-	-	-	-	+	+	-	+	+	-	-	+	-	-	+	-	+	+	-	-	-	-	-	+	-	-	+	-	-	+
6710	+	+	-	-	-	-	+	+	-	+	+	-	-	+	-	+	+	-	+	+	-	-	-	-	-	+	-	-	+	-	+	-
6710	+	+	-	-	+/-	-	+	+	-	+	+	+	-	+	-	+	+	-	+	+	-	-	-	-	-	+	+	-	+	-	-	-

Isolation, sampling and environmental information

isolation

@ref: 6710
sample type: clinical sample
geographic location: Lüdenscheid
country: Germany
origin.country: DEU
continent: Europe
latitude: 51.2191
longitude: 7.6313

isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Built environment
#Infection	#Medical environment	#Clinic

Safety information

risk assessment

@ref: 6710
biosafety level: 2
biosafety level comment: Risk group (German classification)

External links

@ref: 6710

culture collection no.: DSM 17050, RKI UW4673/03, Van A

straininfo link

@ref: 74790
straininfo: 297649

literature

topic	Pubmed-ID	title	authors	journal	DOI	year	mesh	topic2
Metabolism	1503450	Evidence for in vivo incorporation of D-lactate into peptidoglycan precursors of vancomycin-resistant enterococci.	Arthur M, Molinas C, Bugg TD, Wright GD, Walsh CT, Courvalin P	Antimicrob Agents Chemother	10.1128/AAC.36.4.867	1992	Drug Resistance, Microbial, Enterococcus faecium/drug effects/metabolism, Lactates/metabolism, Lactic Acid, Microbial Sensitivity Tests, Peptidoglycan/*metabolism, Vancomycin/metabolism/pharmacology	Pathogenicity
Pathogenicity	1510448	Characterization of vanY, a DD-carboxypeptidase from vancomycin-resistant Enterococcus faecium BM4147.	Wright GD, Molinas C, Arthur M, Courvalin P, Walsh CT	Antimicrob Agents Chemother	10.1128/AAC.36.7.1514	1992	Carboxypeptidases/biosynthesis/metabolism, Chromatography, High Pressure Liquid, Drug Resistance, Microbial, Enterococcus faecium/drug effects/enzymology/genetics, Multigene Family/drug effects, R Factors/drug effects, Uridine Diphosphate N-Acetylmuramic Acid/analogs & derivatives/metabolism, Vancomycin/*pharmacology	Metabolism
Pathogenicity	1510455	Inconsistent bactericidal activity of triple-combination therapy with vancomycin, ampicillin, and gentamicin against vancomycin-resistant, highly ampicillin-resistant Enterococcus faecium.	Fraimow HS, Venuti E	Antimicrob Agents Chemother	10.1128/AAC.36.7.1563	1992	Ampicillin/pharmacology, Ampicillin Resistance, Drug Resistance, Microbial, Drug Therapy, Combination, Enterococcus faecium/drug effects/isolation & purification, Gentamicins/pharmacology, Humans, Microbial Sensitivity Tests, Vancomycin/pharmacology	Enzymology
Enzymology	1556077	The VanS-VanR two-component regulatory system controls synthesis of depsipeptide peptidoglycan precursors in Enterococcus faecium BM4147.	Arthur M, Molinas C, Courvalin P	J Bacteriol	10.1128/jb.174.8.2582-2591.1992	1992	Amino Acid Sequence, Bacterial Proteins, Base Sequence, Cloning, Molecular, DNA Mutational Analysis, DNA, Bacterial/genetics, Drug Resistance, Microbial, Enterococcus faecium/drug effects/enzymology, Genes, Bacterial, Genes, Regulator, Molecular Sequence Data, Oligodeoxyribonucleotides/chemistry, Peptidoglycan/biosynthesis, Polymerase Chain Reaction, Promoter Regions, Genetic, Protein Kinases/genetics, Sequence Alignment, Transcription Factors/genetics, Transcription, Genetic, Vancomycin/pharmacology	Genetics
Pathogenicity	1562656	Concomitant high-level vancomycin and penicillin resistance in clinical isolates of enterococci.	Handwerger S, Perlman DC, Altarac D, McAuliffe V	Clin Infect Dis	10.1093/clinids/14.3.655	1992	Aged, Ampicillin Resistance, Bacterial Proteins, Carrier Proteins/analysis, Conjugation, Genetic, Drug Resistance, Microbial, Drug Synergism, Enterococcus faecalis/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Female, Hexosyltransferases, Humans, Microbial Sensitivity Tests, Muramoylpentapeptide Carboxypeptidase/analysis, Penicillin Resistance, Penicillin-Binding Proteins, Peptidyl Transferases, Vancomycin/pharmacology
Enzymology	1931965	Molecular basis for vancomycin resistance in Enterococcus faecium BM4147: biosynthesis of a depsipeptide peptidoglycan precursor by vancomycin resistance proteins VanH and VanA.	Bugg TD, Wright GD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT	Biochemistry	10.1021/bi00107a007	1991	Amino Acid Sequence, Bacterial Proteins/genetics/isolation & purification/metabolism, Carbon-Oxygen Ligases, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Genes, Bacterial, Kinetics, L-Lactate Dehydrogenase/metabolism, Molecular Sequence Data, Protein Precursors/biosynthesis, Sequence Alignment, Substrate Specificity, Vancomycin/metabolism/pharmacology	Metabolism
Enzymology	1998664	Identification of vancomycin resistance protein VanA as a D-alanine:D-alanine ligase of altered substrate specificity.	Bugg TD, Dutka-Malen S, Arthur M, Courvalin P, Walsh CT	Biochemistry	10.1021/bi00222a002	1991	Amino Acid Sequence, Bacterial Proteins/genetics/isolation & purification/metabolism, Carbon-Oxygen Ligases, Chromatography, Gel, Drug Resistance, Microbial/physiology, Gram-Negative Bacteria/enzymology, Molecular Sequence Data, Peptide Synthases/genetics/isolation & purification/metabolism, Streptococcus/drug effects/enzymology, Substrate Specificity, Vancomycin/*pharmacology	Phylogeny
Pathogenicity	7492109	In vitro activity of the semisynthetic glycopeptide amide MDL 63,246.	Kenny MT, Brackman MA, Dulworth JK	Antimicrob Agents Chemother	10.1128/AAC.39.7.1589	1995	Anti-Bacterial Agents/pharmacology, Gram-Positive Cocci/drug effects, Microbial Sensitivity Tests, Teicoplanin/analogs & derivatives/pharmacology, Vancomycin/pharmacology
Genetics	7726499	Heterogeneity of the vanA gene cluster in clinical isolates of enterococci from the northeastern United States.	Handwerger S, Skoble J, Discotto LF, Pucci MJ	Antimicrob Agents Chemother	10.1128/AAC.39.2.362	1995	Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Carbon-Oxygen Ligases, DNA Transposable Elements, Enterococcus faecium/genetics, Genes, Bacterial, Ligases/genetics, Molecular Sequence Data, Multigene Family, Open Reading Frames
Enzymology	7852582	Evaluation and characterization of multiresistant Enterococcus faecium from 12 U.S. medical centers.	Sader HS, Pfaller MA, Tenover FC, Hollis RJ, Jones RN	J Clin Microbiol	10.1128/jcm.32.11.2840-2842.1994	1994	DNA, Bacterial/analysis, Drug Resistance, Microbial, Drug Resistance, Multiple, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/*drug effects/genetics	Pathogenicity
Metabolism	7854121	Glycopeptide resistance mediated by enterococcal transposon Tn1546 requires production of VanX for hydrolysis of D-alanyl-D-alanine.	Reynolds PE, Depardieu F, Dutka-Malen S, Arthur M, Courvalin P	Mol Microbiol	10.1111/j.1365-2958.1994.tb00497.x	1994	Alanine/analogs & derivatives/metabolism, Amino Acid Sequence, Bacterial Proteins/biosynthesis/genetics/physiology, Base Sequence, Carbon-Oxygen Ligases, DNA Transposable Elements/genetics, Dipeptides/metabolism, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Gene Expression Regulation, Bacterial, Genes, Bacterial, Hydrolysis, Lactates/metabolism, Ligases/biosynthesis/genetics, Molecular Sequence Data, Peptidoglycan/metabolism, Protein Kinases/biosynthesis/genetics, Pyruvates/metabolism, Pyruvic Acid, Serine-Type D-Ala-D-Ala Carboxypeptidase, Teicoplanin/pharmacology, Transcription Factors/biosynthesis/genetics, Vancomycin/*pharmacology	Genetics
Pathogenicity	7868403	Farm animals as a putative reservoir for vancomycin-resistant enterococcal infection in man.	Bates J, Jordens JZ, Griffiths DT	J Antimicrob Chemother	10.1093/jac/34.4.507	1994	Animals, Animals, Domestic/microbiology, Cattle, Disease Reservoirs, Dogs, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Food Microbiology, Gram-Positive Bacterial Infections/microbiology, Horses, Humans, Meat, Microbial Sensitivity Tests, Polymerase Chain Reaction, Poultry, Sewage, Sheep, Swine, United Kingdom, Vancomycin/*pharmacology, Water Microbiology	Biotechnology
Genetics	8040119	vanA-mediated vancomycin-resistant Enterococcus spp. in sewage.	Torres C, Reguera JA, Sanmartin MJ, Perez-Diaz JC, Baquero F	J Antimicrob Chemother	10.1093/jac/33.3.553	1994	Bacterial Proteins/genetics/physiology, Base Sequence, Carbon-Oxygen Ligases, Conjugation, Genetic, Drug Resistance, Microbial/genetics, Enterococcus/drug effects/genetics, Ligases/genetics/physiology, Molecular Sequence Data, Nucleic Acid Hybridization, Sewage, Vancomycin/pharmacology, *Water Microbiology	Phylogeny
Enzymology	8285611	Characterization of glycopeptide-resistant enterococci from U.S. hospitals.	Clark NC, Cooksey RC, Hill BC, Swenson JM, Tenover FC	Antimicrob Agents Chemother	10.1128/AAC.37.11.2311	1993	Anti-Bacterial Agents/pharmacology, Base Sequence, Cross Infection/microbiology, DNA, Bacterial/analysis/isolation & purification, Drug Resistance, Microbial/genetics, Electrophoresis, Polyacrylamide Gel, Enterococcus/drug effects/genetics, Glycopeptides, Gram-Positive Bacterial Infections/*microbiology, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Nucleic Acid Hybridization, Plasmids, Polymerase Chain Reaction, United States	Phylogeny
Pathogenicity	8328775	Constitutively vancomycin-resistant Enterococcus faecium resistant to synergistic beta-lactam combinations.	Green M, Binczewski B, Pasculle AW, Edmund M, Barbadora K, Kusne S, Shlaes DM	Antimicrob Agents Chemother	10.1128/AAC.37.6.1238	1993	Adult, Anti-Bacterial Agents/pharmacology, Base Sequence, DNA Probes, Drug Resistance, Microbial, Drug Synergism, Drug Therapy, Combination/pharmacology, Enterococcus faecium/drug effects/genetics/physiology, Humans, Immunoblotting, Microbial Sensitivity Tests, Molecular Sequence Data, Novobiocin/pharmacology, Penicillins/pharmacology, Phenotype, Vancomycin/pharmacology, beta-Lactams	Genetics
Enzymology	8486959	In vivo development of teicoplanin resistance in a VanB Enterococcus faecium isolate.	Hayden MK, Trenholme GM, Schultz JE, Sahm DF	J Infect Dis	10.1093/infdis/167.5.1224	1993	Bacterial Proteins/genetics, Drug Resistance, Microbial/genetics, Electrophoresis, Gel, Pulsed-Field, Electrophoresis, Polyacrylamide Gel, Enterococcus faecium/drug effects/genetics, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, Infant, Middle Aged, Teicoplanin/pharmacology, Vancomycin/pharmacology	Pathogenicity
Pathogenicity	8641304	In vitro conjugative transfer of VanA vancomycin resistance between Enterococci and Listeriae of different species.	Biavasco F, Giovanetti E, Miele A, Vignaroli C, Facinelli B, Varaldo PE	Eur J Clin Microbiol Infect Dis	10.1007/BF01586185	1996	Anti-Bacterial Agents/pharmacology, Base Sequence, Conjugation, Genetic, Drug Resistance, Microbial/genetics, Enterococcus/drug effects/genetics, Listeria/drug effects/genetics, Molecular Sequence Data, Vancomycin/*pharmacology	Genetics
Genetics	8675038	Mobilization of vancomycin resistance by transposon-mediated fusion of a VanA plasmid with an Enterococcus faecium sex pheromone-response plasmid.	Heaton MP, Discotto LF, Pucci MJ, Handwerger S	Gene	10.1016/0378-1119(96)00022-4	1996	Amino Acid Sequence, Anti-Bacterial Agents/pharmacology, Bacterial Adhesion/genetics, Bacterial Proteins/genetics, Base Sequence, Conjugation, Genetic/genetics, DNA Transposable Elements/genetics, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Molecular Sequence Data, Open Reading Frames/genetics, Plasmids/genetics, Replicon/genetics, Sex Attractants/genetics, Vancomycin/*pharmacology	Pathogenicity
Pathogenicity	8792949	Vancomycin-resistant enterococci.	Gin AS, Zhanel GG	Ann Pharmacother	10.1177/106002809603000610	1996	Animals, Anti-Bacterial Agents/pharmacology/therapeutic use, Clinical Trials as Topic, Drug Resistance, Microbial, Enterococcus/drug effects/genetics, Humans, Phenotype, Vancomycin/*pharmacology/therapeutic use	Phenotype
Metabolism	8807826	Synthesis and evaluation of inhibitors of bacterial D-alanine:D-alanine ligases.	Ellsworth BA, Tom NJ, Bartlett PA	Chem Biol	10.1016/s1074-5521(96)90082-4	1996	Bacteria/enzymology, Enzyme Inhibitors/chemical synthesis/metabolism/pharmacology, Peptide Synthases/antagonists & inhibitors/metabolism, Substrate Specificity	Enzymology
Pathogenicity	8843309	Glycopeptide susceptibility among Danish Enterococcus faecium and Enterococcus faecalis isolates of animal and human origin and PCR identification of genes within the VanA cluster.	Aarestrup FM, Ahrens P, Madsen M, Pallesen LV, Poulsen RL, Westh H	Antimicrob Agents Chemother	10.1128/AAC.40.8.1938	1996	Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases, Cattle/microbiology, Chickens/microbiology, DNA Transposable Elements, Denmark, Drug Resistance, Microbial/genetics, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial, Glycopeptides, Humans, Ligases/genetics, Microbial Sensitivity Tests, Multigene Family, Polymerase Chain Reaction, Serine-Type D-Ala-D-Ala Carboxypeptidase, Swine/microbiology, Transcription Factors/genetics, Vancomycin/pharmacology	Enzymology
Metabolism	8843432	Quantitative analysis of the metabolism of soluble cytoplasmic peptidoglycan precursors of glycopeptide-resistant enterococci.	Arthur M, Depardieu F, Reynolds P, Courvalin P	Mol Microbiol	10.1046/j.1365-2958.1996.00617.x	1996	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases, Cytoplasm/metabolism, DNA Transposable Elements, Dipeptidases/genetics/metabolism, Drug Resistance, Microbial/genetics, Enterococcus/drug effects/genetics/metabolism, Enterococcus faecalis/drug effects/genetics/metabolism, Enterococcus faecium/drug effects/genetics/metabolism, Genes, Bacterial, Genetic Complementation Test, Glycopeptides/pharmacology, Ligases/genetics/metabolism, Multigene Family, Peptidoglycan/metabolism, Plasmids/genetics, Protein Precursors/metabolism, *Serine-Type D-Ala-D-Ala Carboxypeptidase, Solubility	Pathogenicity
Pathogenicity	8849237	In vitro activities of U-100592 and U-100766, novel oxazolidinone antibacterial agents.	Zurenko GE, Yagi BH, Schaadt RD, Allison JW, Kilburn JO, Glickman SE, Hutchinson DK, Barbachyn MR, Brickner SJ	Antimicrob Agents Chemother	10.1128/AAC.40.4.839	1996	Acetamides/pharmacology, Anti-Bacterial Agents/pharmacology, Bacteria/drug effects, Drug Resistance, Microbial, Linezolid, Microbial Sensitivity Tests, Oxazoles/pharmacology, *Oxazolidinones, Vancomycin/pharmacology
Pathogenicity	8923271	Epidemiology of an outbreak due to glycopeptide-resistant Enterococcus faecium on a leukaemia unit.	Chadwick PR, Oppenheim BA, Fox A, Woodford N, Morgenstern GR, Scarffe JH	J Hosp Infect	10.1016/s0195-6701(96)90063-8	1996	Adult, Anti-Bacterial Agents/pharmacology, Cross Infection/epidemiology/microbiology/prevention & control, DNA Fingerprinting, DNA, Bacterial, Disease Outbreaks/prevention & control, Drug Resistance, Microbial, England/epidemiology, Enterococcus faecium/drug effects/isolation & purification, Female, Gram-Positive Bacterial Infections/epidemiology/microbiology/prevention & control, Humans, Infection Control/methods, Leukemia/*complications, Male, Middle Aged, Vancomycin/pharmacology	Enzymology
Genetics	8981985	The VanS sensor negatively controls VanR-mediated transcriptional activation of glycopeptide resistance genes of Tn1546 and related elements in the absence of induction.	Arthur M, Depardieu F, Gerbaud G, Galimand M, Leclercq R, Courvalin P	J Bacteriol	10.1128/jb.179.1.97-106.1997	1997	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/biosynthesis/genetics, Chloramphenicol O-Acetyltransferase/genetics, Conjugation, Genetic, DNA Transposable Elements/genetics, Dipeptidases/biosynthesis, Drug Resistance, Microbial/genetics, Enterococcus faecalis/genetics, Enterococcus faecium/drug effects/enzymology/genetics, Gene Expression Regulation, Bacterial/drug effects/genetics, Genes, Reporter/genetics, Glycopeptides, Molecular Sequence Data, Multigene Family/genetics, Mutation, Operon/genetics, Polymorphism, Restriction Fragment Length, Promoter Regions, Genetic/genetics, Protein Kinases/genetics/physiology, Recombinant Fusion Proteins, Serine-Type D-Ala-D-Ala Carboxypeptidase, Transcription Factors/genetics/physiology, Transcriptional Activation/drug effects/*physiology	Pathogenicity
Pathogenicity	9158753	Conjugative mobilization of a vancomycin resistance plasmid by a putative Enterococcus faecium sex pheromone response plasmid.	Heaton MP, Handwerger S	Microb Drug Resist	10.1089/mdr.1995.1.177	1995	Anti-Bacterial Agents/pharmacology, Conjugation, Genetic/genetics, DNA Probes, DNA, Bacterial/analysis/isolation & purification, Enterococcus faecium/drug effects/genetics, Erythromycin/pharmacology, Gram-Negative Bacterial Infections/microbiology, Humans, Plasmids/genetics, Restriction Mapping, Sex Attractants/pharmacology, Vancomycin/pharmacology	Genetics
Pathogenicity	9158786	Enterococcus faecium strains with vanA-mediated high-level glycopeptide resistance isolated from animal foodstuffs and fecal samples of humans in the community.	Klare I, Heier H, Claus H, Bohme G, Marin S, Seltmann G, Hakenbeck R, Antanassova V, Witte W	Microb Drug Resist	10.1089/mdr.1995.1.265	1995	Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/analysis/genetics, Carbon-Oxygen Ligases, Chickens, DNA Fingerprinting, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/enzymology/genetics, Feces/microbiology, Food Microbiology, Genes, Bacterial/genetics, Germany, Glycopeptides, Humans, Ligases/analysis/genetics, *Meat, Meat Products, Microbial Sensitivity Tests, Swine, Turkeys	Biotechnology
Pathogenicity	9230375	Rapid characterization schemes for surveillance isolates of vancomycin-resistant enterococci.	Sahm DF, Free L, Smith C, Eveland M, Mundy LM	J Clin Microbiol	10.1128/jcm.35.8.2026-2030.1997	1997	Anti-Bacterial Agents/pharmacology, Drug Resistance, Microbial/genetics, Enterococcus/drug effects/genetics/*isolation & purification, Humans, Microbiological Techniques, Phenotype, Polymerase Chain Reaction, Vancomycin/pharmacology	Phenotype
Enzymology	9255886	Intrahospital spread of vancomycin-resistant Enterococcus faecium in Sweden.	Torell E, Fredlund H, Tornquist E, Myhre EB, Sjoberg L, Sundsfjord A	Scand J Infect Dis	10.3109/00365549709019039	1997	Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases, Cross Infection/epidemiology/microbiology/transmission, DNA, Bacterial/chemistry/genetics, Disease Outbreaks, Drug Resistance, Microbial, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification, Female, Gram-Positive Bacterial Infections/epidemiology/microbiology/transmission, Humans, Ligases/genetics, Male, Middle Aged, Polymerase Chain Reaction, Sweden/epidemiology, Vancomycin/*pharmacology	Pathogenicity
Genetics	9257766	Identification and characterization of IS1476, an insertion sequence-like element that disrupts VanY function in a vancomycin-resistant Enterococcus faecium strain.	MacKinnon MG, Drebot MA, Tyrrell GJ	Antimicrob Agents Chemother	10.1128/AAC.41.8.1805	1997	Anti-Bacterial Agents/pharmacology, DNA Transposable Elements/genetics, DNA, Bacterial/analysis, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Genes, Bacterial/genetics, Molecular Sequence Data, Vancomycin/pharmacology	Pathogenicity
Genetics	9303405	VanD-type glycopeptide-resistant Enterococcus faecium BM4339.	Perichon B, Reynolds P, Courvalin P	Antimicrob Agents Chemother	10.1128/AAC.41.9.2016	1997	Amino Acid Sequence, Anti-Bacterial Agents/pharmacology, Base Sequence, Drug Resistance, Microbial, Enterococcus faecium/drug effects/enzymology/genetics, Genes, Bacterial, Genotype, Molecular Sequence Data, Peptide Synthases/genetics/metabolism, Sequence Homology, Amino Acid, Teicoplanin/pharmacology, Vancomycin/*pharmacology	Enzymology
Genetics	9350769	Strains of glycopeptide-resistant Enterococcus faecium can alter their van genotypes during an outbreak.	Woodford N, Chadwick PR, Morrison D, Cookson BD	J Clin Microbiol	10.1128/jcm.35.11.2966-2968.1997	1997	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/biosynthesis/genetics, Carbon-Oxygen Ligases/biosynthesis/genetics, Cross Infection/epidemiology/microbiology, Disease Outbreaks, Drug Resistance, Microbial, Enterococcus faecium/classification/drug effects, Genes, Bacterial, Genotype, Gram-Positive Bacterial Infections/epidemiology, Humans, Microbial Sensitivity Tests/methods, Multigene Family, Plasmids, Teicoplanin/pharmacology, Vancomycin/pharmacology	Pathogenicity
Enzymology	9461358	Control of a nosocomial outbreak of vancomycin resistant Enterococcus faecium in a paediatric oncology unit: risk factors for colonisation.	Nourse C, Murphy H, Byrne C, O'Meara A, Breatnach F, Kaufmann M, Clarke A, Butler K	Eur J Pediatr	10.1007/s004310050760	1998	Adolescent, Anti-Bacterial Agents/pharmacology/therapeutic use, Case-Control Studies, Child, Child, Preschool, Colony Count, Microbial, Confidence Intervals, Cross Infection/drug therapy/epidemiology/prevention & control, Disease Outbreaks/prevention & control, Drug Resistance, Microbial, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/isolation & purification, Feces/microbiology, Female, Gram-Positive Bacterial Infections/drug therapy/epidemiology/prevention & control, Humans, Infection Control/methods, Male, Mass Screening/methods, Odds Ratio, Oncology Service, Hospital, Risk Factors, Vancomycin/pharmacology/therapeutic use	Pathogenicity
Metabolism	9517923	Diversity of VanA glycopeptide resistance elements in enterococci from humans and nonhuman sources.	Woodford N, Adebiyi AM, Palepou MF, Cookson BD	Antimicrob Agents Chemother	10.1128/AAC.42.3.502	1998	Animals, Anti-Bacterial Agents/metabolism, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Cross Infection/microbiology, DNA Transposable Elements/genetics, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/*genetics, Glycopeptides, Gram-Positive Bacterial Infections/microbiology, Humans, Phenotype, Repetitive Sequences, Nucleic Acid	Pathogenicity
Pathogenicity	9593132	Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin.	Eliopoulos GM, Wennersten CB, Gold HS, Schulin T, Souli M, Farris MG, Cerwinka S, Nadler HL, Dowzicky M, Talbot GH, Moellering RC Jr	Antimicrob Agents Chemother	10.1128/AAC.42.5.1088	1998	Anti-Bacterial Agents/pharmacology, Drug Resistance, Microbial, Enterococcus faecium/drug effects/isolation & purification/metabolism, Humans, Microbial Sensitivity Tests, United States, Vancomycin/pharmacology, Virginiamycin/*pharmacology	Enzymology
Pathogenicity	9665988	Emergence of vancomycin-resistant enterococci in Australia: phenotypic and genotypic characteristics of isolates.	Bell JM, Paton JC, Turnidge J	J Clin Microbiol	10.1128/JCM.36.8.2187-2190.1998	1998	Anti-Bacterial Agents/pharmacology, Australia/epidemiology, Bacterial Proteins/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Drug Resistance, Microbial/genetics, Enterococcus/classification/drug effects/genetics/isolation & purification, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Phenotype, Polymerase Chain Reaction/methods, Teicoplanin/pharmacology, Vancomycin/pharmacology	Phylogeny
Pathogenicity	9764397	European Glycopeptide Susceptibility Survey of gram-positive bacteria for 1995. European Glycopeptide Resistance Survey Study Group.	Felmingham D, Brown DF, Soussy CJ	Diagn Microbiol Infect Dis	10.1016/s0732-8893(98)00053-4	1998	Anti-Bacterial Agents/pharmacology, Coagulase/metabolism, Drug Resistance, Microbial, Drug Resistance, Multiple, Enterococcus/drug effects, Europe, Gram-Positive Bacteria/drug effects, Humans, Microbial Sensitivity Tests, Staphylococcus/drug effects/enzymology, Streptococcus/drug effects, Teicoplanin/pharmacology, Vancomycin/pharmacology	Metabolism
Pathogenicity	9788808	Glycopeptide-resistant enterococci: a decade of experience.	Woodford N	J Med Microbiol	10.1099/00222615-47-10-849	1998	Animals, Anti-Bacterial Agents/pharmacology, Cross Infection/drug therapy/epidemiology, DNA Transposable Elements, Disease Reservoirs, Drug Resistance, Microbial/genetics, Enterococcus/drug effects/enzymology/genetics, Europe/epidemiology, Global Health, *Glycopeptides, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Humans, Ligases/genetics, Multigene Family, Phylogeny, United Kingdom/epidemiology, United States/epidemiology	Phylogeny
Enzymology	9819690	Epidemiology and control of vancomycin-resistant enterococci (VRE) in a renal unit.	Brown AR, Amyes SG, Paton R, Plant WD, Stevenson GM, Winney RJ, Miles RS	J Hosp Infect	10.1016/s0195-6701(98)90090-1	1998	Anti-Bacterial Agents/pharmacology, Cross Infection/epidemiology/prevention & control, DNA, Bacterial/analysis, Disease Outbreaks, Drug Resistance, Microbial, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Genotype, Gram-Positive Bacterial Infections/epidemiology/prevention & control, Hemodialysis Units, Hospital, Humans, Infection Control/methods, Kidney Diseases/complications, Microbial Sensitivity Tests, Phenotype, Polymerase Chain Reaction, Scotland/epidemiology, Vancomycin/pharmacology	Pathogenicity
Enzymology	9841835	The changing molecular epidemiology and establishment of endemicity of vancomycin resistance in enterococci at one hospital over a 6-year period.	Kim WJ, Weinstein RA, Hayden MK	J Infect Dis	10.1086/314564	1999	Adult, Aged, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Chicago/epidemiology, Cross Infection/drug therapy/epidemiology/microbiology, DNA, Bacterial/genetics/isolation & purification, Drug Resistance, Microbial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus/classification/drug effects/genetics, Female, Genotype, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology, Hospitals, Teaching, Humans, Longitudinal Studies, Male, Middle Aged, Molecular Epidemiology, Polymerase Chain Reaction, Vancomycin/pharmacology	Pathogenicity
Pathogenicity	9988050	Transmission of VanA-type vancomycin-resistant enterococci and vanA resistance elements between chicken and humans at avoparcin-exposed farms.	Simonsen GS, Haaheim H, Dahl KH, Kruse H, Lovseth A, Olsvik O, Sundsfjord A	Microb Drug Resist	10.1089/mdr.1998.4.313	1998	Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Chickens/microbiology, DNA, Bacterial/analysis, Disease Reservoirs, Drug Resistance, Microbial, Drug Resistance, Multiple, Enterococcus/drug effects/genetics/isolation & purification, Feces/microbiology, Glycopeptides, Humans, Meat/microbiology, Microbial Sensitivity Tests, Norway, Vancomycin/pharmacology	Enzymology
Phylogeny	10063476	Isolation and epidemiological study of vancomycin-resistant Enterococcus faecium from patients of a haematological unit in Poland.	Samet A, Bronk M, Hellmann A, Kur J	J Hosp Infect	10.1016/s0195-6701(99)90051-8	1999	Adult, Anti-Bacterial Agents, Cross Infection/microbiology, DNA Fingerprinting, DNA, Bacterial/genetics, Drug Resistance, Microbial, Enterococcus faecium/classification/genetics/isolation & purification, Female, Gram-Positive Bacterial Infections/microbiology, Hematology, Hospital Units, Humans, Infection Control, Male, Microbial Sensitivity Tests, Middle Aged, Poland, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Serotyping, Teicoplanin, Vancomycin	Pathogenicity
Pathogenicity	10066045	Low faecal carrier rate of vancomycin resistant enterococci in Norwegian hospital patients.	Simonsen GS, Andersen BM, Digranes A, Harthug S, Jacobsen T, Lingaas E, Natas OB, Olsvik O, Ringertz SH, Skulberg A, Syversen G, Sundsfjord A	Scand J Infect Dis	10.1080/00365549850161449	1998	Anti-Bacterial Agents/pharmacology, Carrier State/epidemiology, Cross Infection/epidemiology/prevention & control, Drug Resistance, Microbial, Enterococcus/drug effects/isolation & purification, Feces/microbiology, Gram-Positive Bacterial Infections/epidemiology/prevention & control, Humans, Norway/epidemiology, Prevalence, Vancomycin/*pharmacology	Enzymology
Pathogenicity	10227164	Nucleotide sequence of IS1542, an insertion sequence identified within VanA glycopeptide resistance elements of enterococci.	Darini AL, Palepou MF, Woodford N	FEMS Microbiol Lett	10.1111/j.1574-6968.1999.tb13523.x	1999	Amino Acid Sequence, Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Base Sequence, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, DNA, Bacterial/analysis, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Humans, Molecular Sequence Data, Poultry/microbiology, Transposases/genetics, Vancomycin/*pharmacology	Genetics
Genetics	10368136	Characterization of the vanD glycopeptide resistance gene cluster from Enterococcus faecium BM4339.	Casadewall B, Courvalin P	J Bacteriol	10.1128/JB.181.12.3644-3648.1999	1999	Amino Acid Sequence, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/chemistry/genetics, Base Sequence, Carboxypeptidases, Chromosomes, Bacterial, Conserved Sequence, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics/growth & development, Escherichia coli/genetics, Frameshift Mutation, Genotype, Membrane Proteins, Molecular Sequence Data, Multigene Family, Open Reading Frames, Peptide Synthases/chemistry/genetics, Plasmids, Sequence Alignment, Streptomyces/genetics, Vancomycin/pharmacology	Pathogenicity
Enzymology	10417422	Crystallization and preliminary X-ray characterization of VanA from Enterococcus faecium BM4147: towards the molecular basis of bacterial resistance to the glycopeptide antibiotic vancomycin.	Huyton T, Roper DI	Acta Crystallogr D Biol Crystallogr	10.1107/s0907444999007155	1999	Bacterial Proteins/chemistry/genetics/isolation & purification, Carbon-Oxygen Ligases/chemistry/genetics/isolation & purification, Crystallization, Crystallography, X-Ray, Drug Resistance, Microbial, Enterococcus faecium/*enzymology/genetics, Escherichia coli/genetics, Recombinant Proteins/chemistry/genetics/isolation & purification, Substrate Specificity, Vancomycin/pharmacology	Phylogeny
Phenotype	10432277	First confirmed case of a vancomycin-resistant Enterococcus faecium with vanA phenotype from Brazil: isolation from a meningitis case in Sao Paulo.	Zanella RC, Valdetaro F, Lovgren M, Tyrrel GJ, Bokermann S, Almeida SC, Vieira VS, Brandileone MC	Microb Drug Resist	10.1089/mdr.1999.5.159	1999	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics/isolation & purification, Female, Humans, Meningitis, Bacterial/microbiology, Microbial Sensitivity Tests, Middle Aged, Phenotype, Polymerase Chain Reaction, Vancomycin/pharmacology	Pathogenicity
Pathogenicity	10479146	A cluster of VanD vancomycin-resistant Enterococcus faecium: molecular characterization and clinical epidemiology.	Ostrowsky BE, Clark NC, Thauvin-Eliopoulos C, Venkataraman L, Samore MH, Tenover FC, Eliopoulos GM, Moellering RC Jr, Gold HS	J Infect Dis	10.1086/315030	1999	Amino Acid Sequence, Bacterial Proteins/genetics, Base Sequence, Chromosome Mapping, DNA Primers, Enterococcus faecium/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Molecular Epidemiology, Molecular Sequence Data, Open Reading Frames, Peptide Synthases/genetics, Polymerase Chain Reaction, Sequence Alignment, Sequence Homology, Amino Acid, Vancomycin/pharmacology, *Vancomycin Resistance	Genetics
Pathogenicity	10722130	Eradication of vancomycin resistant Enterococcus faecium from a paediatric oncology unit and prevalence of colonization in hospitalized and community-based children.	Nourse C, Byrne C, Murphy H, Kaufmann ME, Clarke A, Butler K	Epidemiol Infect	10.1017/s095026889900326x	2000	Adolescent, Child, Child, Preschool, Cross Infection/complications/epidemiology/prevention & control, Disease Outbreaks/prevention & control, Enterococcus faecium, Female, Gram-Positive Bacterial Infections/complications/epidemiology/prevention & control, Hospital Units, Humans, Infant, Infection Control/methods, Ireland/epidemiology, Male, Mass Screening, Neoplasms/microbiology, Prevalence, *Vancomycin Resistance
Genetics	10770779	Effects of the movement of insertion sequences on the structure of VanA glycopeptide resistance elements in Enterococcus faecium.	Darini AL, Palepou MF, Woodford N	Antimicrob Agents Chemother	10.1128/AAC.44.5.1362-1364.2000	2000	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements/genetics, Drug Resistance, Microbial/genetics, Enterococcus faecium/drug effects/genetics, Gene Deletion, Genome, Bacterial, Glycopeptides, Polymerase Chain Reaction	Pathogenicity
Phylogeny	10834961	Evaluation of a new system, VITEK 2, for identification and antimicrobial susceptibility testing of enterococci.	Garcia-Garrote F, Cercenado E, Bouza E	J Clin Microbiol	10.1128/JCM.38.6.2108-2111.2000	2000	Bacterial Typing Techniques/instrumentation/standards, Drug Resistance, Microbial, Enterococcus/classification/drug effects, Evaluation Studies as Topic, Microbial Sensitivity Tests/instrumentation/standards, Time Factors	Pathogenicity
Pathogenicity	10834962	Isolation and characterization of glycopeptide-resistant enterococci from hospitalized patients over a 30-month period.	Nelson RR, McGregor KF, Brown AR, Amyes SG, Young H	J Clin Microbiol	10.1128/JCM.38.6.2112-2116.2000	2000	Aminoglycosides, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Bacterial Typing Techniques, Cross Infection/epidemiology, Electrophoresis, Gel, Pulsed-Field, Enterococcus/classification/drug effects/genetics, Glycopeptides, Gram-Positive Bacterial Infections/epidemiology, Humans, Molecular Epidemiology, Scotland, Vancomycin Resistance	Phylogeny
Pathogenicity	10868807	Typeability of Tn1546-like elements in vancomycin-resistant enterococci using long-range PCRs and specific analysis of polymorphic regions.	Simonsen GS, Myhre MR, Dahl KH, Olsvik O, Sundsfjord A	Microb Drug Resist	10.1089/mdr.2000.6.49	2000	Base Sequence, DNA Primers, DNA Transposable Elements, Enterococcus/drug effects/genetics, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction/methods, Polymorphism, Restriction Fragment Length, Vancomycin Resistance/*genetics
Pathogenicity	10908650	The molecular basis of vancomycin resistance in clinically relevant Enterococci: crystal structure of D-alanyl-D-lactate ligase (VanA).	Roper DI, Huyton T, Vagin A, Dodson G	Proc Natl Acad Sci U S A	10.1073/pnas.150116497	2000	Bacterial Proteins/chemistry, Carbon-Oxygen Ligases/chemistry, Crystallography, X-Ray, Enterococcus faecium/drug effects, Hydrogen Bonding, Protein Conformation, Vancomycin Resistance
Pathogenicity	10921944	PCR fragment length polymorphism analysis of vancomycin-resistant Enterococcus faecium.	Donabedian S, Hershberger E, Thal LA, Chow JW, Clewell DB, Robinson-Dunn B, Zervos MJ	J Clin Microbiol	10.1128/JCM.38.8.2885-2888.2000	2000	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements/genetics, DNA, Bacterial/analysis/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Polymerase Chain Reaction/methods, Polymorphism, Genetic, Taq Polymerase/metabolism, Vancomycin Resistance/*genetics	Enzymology
Pathogenicity	10950627	Problems and perils of vancomycin resistant enterococci.	Murray BE	Braz J Infect Dis		2000	Enterococcus/drug effects/genetics, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, *Vancomycin Resistance/genetics
Enzymology	10966227	Genotypic characterisation of endemic VanA Enterococcus faecium strains isolated in a paediatric hospital.	Barnaud G, Bingen E	J Med Microbiol	10.1099/0022-1317-49-9-793	2000	Adolescent, Adult, Bacterial Proteins/isolation & purification, Carbon-Oxygen Ligases/isolation & purification, Child, Child, Preschool, Cross Infection/epidemiology/microbiology, Electrophoresis, Gel, Pulsed-Field, Endemic Diseases, Enterococcus faecium/drug effects/genetics, Feces/microbiology, Female, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, Pediatric, Hospitals, University, Humans, Infant, Male, Polymorphism, Restriction Fragment Length, Vancomycin Resistance	Pathogenicity
Enzymology	10970377	Outbreak of vancomycin-resistant enterococci in a hospital in Gdask, Poland, due to horizontal transfer of different Tn1546-like transposon variants and clonal spread of several strains.	Kawalec M, Gniadkowski M, Hryniewicz W	J Clin Microbiol	10.1128/JCM.38.9.3317-3322.2000	2000	Adult, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Gene Transfer, Horizontal, Genetic Variation, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, University, Humans, Microbial Sensitivity Tests, Poland/epidemiology, Polymorphism, Restriction Fragment Length, Vancomycin Resistance/genetics	Pathogenicity
Pathogenicity	11036050	Impact of flavophospholipol and vancomycin on conjugational transfer of vancomycin resistance plasmids.	Riedl S, Ohlsen K, Werner G, Witte W, Hacker J	Antimicrob Agents Chemother	10.1128/AAC.44.11.3189-3192.2000	2000	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Bambermycins/pharmacology, Carbon-Oxygen Ligases/genetics, Conjugation, Genetic/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Plasmids/genetics, Vancomycin/pharmacology, Vancomycin Resistance/*genetics
Pathogenicity	11064468	Vancomycin-resistant Enterococcus faecium infection in three children given allogeneic hematopoietic stem cell transplantation: clinical and microbiologic features.	Carretto E, Barbarini D, Locatelli F, Giraldi E, Pellegrini N, Perversi L, Grossi P, Marone P, Bonetti F	Haematologica		2000	Anti-Bacterial Agents/administration & dosage, Child, Preschool, Drug Therapy, Combination, Enterococcus faecium/drug effects, Female, Gram-Positive Bacterial Infections/drug therapy/etiology, Hematopoietic Stem Cell Transplantation/adverse effects, Humans, Infant, Male, Peptides, Transplantation, Homologous/adverse effects, *Vancomycin Resistance
Phylogeny	11158160	Vancomycin-resistant Enterococcus faecium strain carrying the vanB2 gene variant in a Polish hospital.	Kawalec M, Gniadkowski M, Zielinska U, Klos W, Hryniewicz W	J Clin Microbiol	10.1128/JCM.39.2.811-815.2001	2001	Acute Disease, Aged, Anti-Bacterial Agents, Bacterial Proteins/genetics, Drug Therapy, Combination/therapeutic use, Enterococcus faecium/classification/genetics/isolation & purification, Fatal Outcome, Female, Genetic Variation, Gram-Positive Bacterial Infections/diagnosis, Humans, Microbial Sensitivity Tests, Multigene Family, Multiple Organ Failure, Necrosis, Pancreatitis/pathology/surgery, Poland, Vancomycin Resistance	Pathogenicity
Pathogenicity	11252326	In-vitro activity of fosfomycin against vancomycin-resistant enterococci.	Allerberger F, Klare I	J Antimicrob Chemother	10.1093/jac/43.2.211	1999	Anti-Bacterial Agents/pharmacology, Enterococcus/drug effects/physiology, Fosfomycin/pharmacology, Microbial Sensitivity Tests/methods, Vancomycin Resistance
Pathogenicity	11328790	Effect of LY333328 against vancomycin-resistant Enterococcus faecium in a rat central venous catheter-associated infection model.	Rupp ME, Fey PD, Longo GM	J Antimicrob Chemother	10.1093/jac/47.5.705	2001	Animals, Anti-Bacterial Agents/therapeutic use, Catheters, Indwelling/microbiology, Disease Models, Animal, Enterococcus faecium/drug effects, Glycopeptides, Gram-Positive Bacterial Infections/drug therapy, Lipoglycopeptides, Male, Prosthesis-Related Infections/*drug therapy, Rats, Rats, Sprague-Dawley, Vancomycin Resistance
Pathogenicity	11453590	Recovery from a single blood culture of two enterococcus gallinarum isolates carrying both vanC-1 and vanA cluster genes and differing in glycopeptide susceptibility.	Biavasco F, Paladini C, Vignaroli C, Foglia G, Manso E, Varaldo PE	Eur J Clin Microbiol Infect Dis	10.1007/pl00011270	2001	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Drug Resistance, Electrophoresis, Gel, Pulsed-Field, Enterococcus/drug effects/*genetics/isolation & purification, Female, Gram-Positive Bacterial Infections, Humans, Immunocompromised Host, Microbial Sensitivity Tests, Middle Aged, Polymerase Chain Reaction, Teicoplanin/pharmacology, Vancomycin/pharmacology, Vancomycin Resistance	Enzymology
Genetics	11478671	Characterisation of VanA and VanB elements from glycopeptide-resistant Enterococcus faecium from Greece.	Demertzi E, Palepou MI, Kaufmann ME, Avlamis A, Woodford N	J Med Microbiol	10.1099/0022-1317-50-8-682	2001	Alleles, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/classification/genetics, Carbon-Oxygen Ligases/classification/genetics, Deoxyribonucleases, Type II Site-Specific, Drug Resistance, Microbial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification, Gene Amplification, Genotype, Greece, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Multigene Family, Phenotype, Point Mutation, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Rectum/microbiology, Teicoplanin/pharmacology, Vancomycin Resistance/genetics	Phylogeny
Metabolism	11535797	The VanY(D) DD-carboxypeptidase of Enterococcus faecium BM4339 is a penicillin-binding protein.	Reynolds PE, Ambur OH, Casadewall B, Courvalin P	Microbiology (Reading)	10.1099/00221287-147-9-2571	2001	Bacterial Proteins/chemistry/genetics/metabolism, Carboxypeptidases/antagonists & inhibitors/chemistry/genetics/metabolism, Carrier Proteins/chemistry/genetics/metabolism, Catalytic Domain, Enterococcus faecium/drug effects/genetics/growth & development/metabolism, Enzyme Inhibitors/pharmacology, Hexosyltransferases, Membrane Proteins, Models, Biological, Muramoylpentapeptide Carboxypeptidase/chemistry/genetics/metabolism, Oligopeptides/metabolism, Penicillin G/pharmacology, Penicillin Resistance, Penicillin-Binding Proteins, Peptidoglycan/metabolism, Peptidyl Transferases, Uridine Diphosphate N-Acetylmuramic Acid/analogs & derivatives/metabolism, Vancomycin Resistance	Pathogenicity
Pathogenicity	11759084	Epidemiology of the genetic elements responsible for acquired glycopeptide resistance in enterococci.	Woodford N	Microb Drug Resist	10.1089/10766290152652774	2001	Anti-Bacterial Agents/pharmacology, Drug Resistance, Microbial, Enterococcus/drug effects/genetics, Genes, Bacterial, Genotype, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Humans, Phenotype, Vancomycin/pharmacology, Vancomycin Resistance/*genetics	Genetics
Pathogenicity	11789720	Comparison of two commercially available selective media to screen for vancomycin-resistant enterococci.	Shigei J, Tan G, Shiao A, de la Maza LM, Peterson EM	Am J Clin Pathol	10.1309/TWY5-04QE-9KV0-52MT	2002	Culture Media, Enterococcus/drug effects/isolation & purification, Humans, *Vancomycin Resistance	Cultivation
	11851705	Identification of enterococci and determination of their glycopeptide resistance in German and Austrian clinical microbiology laboratories.	Klare I, Badstubner D, Konstabel C, Witte W	Clin Microbiol Infect	10.1111/j.1469-0691.1999.tb00431.x	1999
	11864101	Colonization by vancomycin-resistant enterococci of the intestinal tract of patients in intensive care units from French general hospitals.	Boisivon A, Thibault M, Leclercq R	Clin Microbiol Infect	10.1111/j.1469-0691.1997.tb00594.x	1997
Phylogeny	11864182	Comparison of agar-based media for primary isolation of glycopeptide-resistant enterococci.	Chadwick PR, Brown DF, Wilcox MH, Collyns TA, Walpole E, Dillon J, Smith R, Gopal Rao G, Oppenheim BA	Clin Microbiol Infect	10.1111/j.1469-0691.1997.tb00308.x	1997
	11866843	Surveillance of intestinal colonization and of infection by vancomycin-resistant enterococci in hospitalized cancer patients.	Moulin F, Dumontier S, Saulnier P, Chachaty E, Loubeyre C, Brugieres L, Andremont A	Clin Microbiol Infect	10.1016/s1198-743x(14)65142-9	1996
Pathogenicity	12019727	The occurrence of vancomycin-resistant enterococci in hematological patients in relation to antibiotic use.	Kolar M, Vagnerova I, Latal T, Urbanek K, Typovska H, Hubacek J, Papajik T, Raida L, Faber E	New Microbiol		2002	Anti-Bacterial Agents/pharmacology/therapeutic use, Drug Resistance, Microbial, Enterococcus/classification/drug effects/isolation & purification, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology, Hematologic Diseases/drug therapy/microbiology, Humans, Retrospective Studies, *Vancomycin Resistance/genetics	Phylogeny
Enzymology	12194774	First characterization of a cluster of VanA-type glycopeptide-resistant Enterococcus faecium, Colombia.	Panesso D, Ospina S, Robledo J, Vela MC, Pena J, Hernandez O, Reyes J, Arias CA	Emerg Infect Dis	10.3201/eid0809.010435	2002	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Colombia, Disease Outbreaks, Drug Resistance, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Evolution, Molecular, Genotype, Glycopeptides, Gram-Positive Bacterial Infections/microbiology, Hospitals, Teaching, Humans, Microbial Sensitivity Tests	Pathogenicity
Cultivation	12202574	Possible connection between a widely disseminated conjugative gentamicin resistance (pMG1-like) plasmid and the emergence of vancomycin resistance in Enterococcus faecium.	Tomita H, Pierson C, Lim SK, Clewell DB, Ike Y	J Clin Microbiol	10.1128/JCM.40.9.3326-3333.2002	2002	Anti-Bacterial Agents/pharmacology, Conjugation, Genetic, Culture Media, Drug Resistance, Bacterial/genetics, Enterococcus faecium/drug effects/genetics, Gene Transfer, Horizontal, Gentamicins/pharmacology, Nucleic Acid Hybridization, Plasmids/genetics, Vancomycin Resistance	Phylogeny
Enzymology	12205065	First outbreak of vancomycin-resistant enterococci in a tertiary hospital in Turkey.	Colak D, Naas T, Gunseren F, Fortineau N, Ogunc D, Gultekin M, Nordmann P	J Antimicrob Chemother	10.1093/jac/dkf134	2002	Adolescent, Adult, Cross Infection/microbiology, DNA, Bacterial/analysis, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial/genetics, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, University, Humans, Infant, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Turkey/epidemiology, *Vancomycin Resistance	Pathogenicity
Pathogenicity	12363004	Stability, persistence, and evolution of plasmid-encoded VanA glycopeptide resistance in enterococci in the absence of antibiotic selection in vitro and in gnotobiotic mice.	Johnsen PJ, Simonsen GS, Olsvik O, Midtvedt T, Sundsfjord A	Microb Drug Resist	10.1089/107662902760326869	2002	Animals, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Enterococcus/drug effects/genetics/growth & development, Germ-Free Life, In Vitro Techniques, Mice, Microbial Sensitivity Tests, Multigene Family, Plasmids, Selection, Genetic, Vancomycin Resistance/*genetics
Pathogenicity	12451730	[Antibiotic resistance in hospital strains of Enterococcus faecalis and Enterococcus faecium].	Mirovic V	Vojnosanit Pregl	10.2298/vsp0205499m	2002	Drug Resistance, Bacterial, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/*drug effects/isolation & purification, Humans, Inpatients, Microbial Sensitivity Tests	Enzymology
Pathogenicity	12499192	A clonal lineage of VanA-type Enterococcus faecalis predominates in vancomycin-resistant Enterococci isolated in New Zealand.	Manson JM, Keis S, Smith JM, Cook GM	Antimicrob Agents Chemother	10.1128/AAC.47.1.204-210.2003	2003	Animals, Enterococcus faecalis/genetics/isolation & purification, Humans, New Zealand, Poultry/genetics, Vancomycin Resistance/*genetics	Enzymology
Pathogenicity	12543654	Activity of tigecycline (GAR-936), a novel glycylcycline, against Enterococci in the mouse peritonitis model.	Nannini EC, Pai SR, Singh KV, Murray BE	Antimicrob Agents Chemother	10.1128/AAC.47.2.529-532.2003	2003	Animals, Anti-Bacterial Agents/pharmacology/therapeutic use, Disease Models, Animal, Enterococcus faecalis/drug effects, Enterococcus faecium/drug effects, Female, Mice, Mice, Inbred ICR, Microbial Sensitivity Tests, Minocycline/analogs & derivatives/pharmacology/therapeutic use, Peritonitis/*drug therapy, Tetracyclines/pharmacology/therapeutic use, Tigecycline, Vancomycin/pharmacology/therapeutic use
Pathogenicity	12572243	Prospective study using standardized methodology for antimicrobial susceptibility of gram-positive cocci isolated from the Puerto Rico Medical Center.	Rodriguez JL, Vazquez GJ, Bermudez M, De Orbeta J, Garcia Y, Rivera Y, Robledo IE	P R Health Sci J		2002	Gram-Positive Cocci/drug effects/isolation & purification, Humans, Microbial Sensitivity Tests/methods, Prospective Studies, Puerto Rico	Enzymology
Pathogenicity	12600007	[Detection of vancomycin-resistant Enterococcus faecium: 2 years' experience in a high complexity hospital ].	Lopreto CR, Viegas Caetano JA, Padlog R, Sorgentini M, Bardi C, Silvestri C	Rev Argent Microbiol		2002	Argentina/epidemiology, Chloramphenicol/pharmacology, Drug Resistance, Drug Resistance, Multiple, Bacterial, Enterococcus faecium/drug effects/isolation & purification, Gentamicins/pharmacology, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, District/statistics & numerical data, Humans, Microbial Sensitivity Tests, Retrospective Studies, Tetracycline/pharmacology, Vancomycin/pharmacology	Enzymology
Pathogenicity	12673410	Sudden increase of vancomycin-resistant enterococcal infections in a Korean tertiary care hospital: possible consequences of increased use of oral vancomycin.	Shin JW, Yong D, Kim MS, Chang KH, Lee K, Kim JM, Chong Y	J Infect Chemother	10.1007/s10156-002-0215-5	2003	Administration, Oral, Adult, Aged, Anti-Bacterial Agents/pharmacology, Child, Preschool, Clostridioides difficile/drug effects, Cross Infection/epidemiology/microbiology/prevention & control, Electrophoresis, Gel, Pulsed-Field, Enterococcus/classification/drug effects/genetics/isolation & purification, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Enterocolitis, Pseudomembranous/drug therapy/microbiology, Female, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, Urban, Humans, Korea, Male, Microbial Sensitivity Tests, Middle Aged, Plasmids, Polymerase Chain Reaction, Vancomycin/administration & dosage/pharmacology/therapeutic use, *Vancomycin Resistance/genetics	Enzymology
Pathogenicity	12729641	Identification of potent and broad-spectrum antibiotics from SAR studies of a synthetic vancomycin analogue.	Ahrendt KA, Olsen JA, Wakao M, Trias J, Ellman JA	Bioorg Med Chem Lett	10.1016/s0960-894x(03)00243-9	2003	Anti-Bacterial Agents/chemical synthesis/pharmacology, Bacteria/drug effects, Combinatorial Chemistry Techniques, Drug Resistance, Bacterial, Enterococcus faecium/drug effects, Microbial Sensitivity Tests, Structure-Activity Relationship, Vancomycin/analogs & derivatives/chemical synthesis/*pharmacology
Pathogenicity	12742321	Geographic variations and trends in antimicrobial resistance among Enterococcus faecalis and Enterococcus faecium in the SENTRY Antimicrobial Surveillance Program (1997-2000).	Mutnick AH, Biedenbach DJ, Jones RN	Diagn Microbiol Infect Dis	10.1016/s0732-8893(03)00012-9	2003	Anti-Bacterial Agents/pharmacology, Drug Resistance, Bacterial, Drug Resistance, Multiple, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Humans, Microbial Sensitivity Tests, Retrospective Studies, Sensitivity and Specificity, *Vancomycin Resistance	Enzymology
Pathogenicity	12801937	European survey of vancomycin-resistant enterococci in at-risk hospital wards and in vitro susceptibility testing of ramoplanin against these isolates.	Goossens H, Jabes D, Rossi R, Lammens C, Privitera G, Courvalin P	J Antimicrob Chemother	10.1093/jac/dkg271	2003	Anti-Bacterial Agents/pharmacology, Cross Infection/epidemiology/microbiology, Depsipeptides, Enterococcus faecalis/drug effects/genetics/isolation & purification, Europe/epidemiology, Feces/microbiology, Gram-Positive Bacterial Infections/epidemiology/microbiology, Health Surveys, Humans, International Cooperation, Microbial Sensitivity Tests, Peptides, Cyclic/pharmacology, Phenotype, Prospective Studies, Vancomycin Resistance/*genetics	Phenotype
Genetics	12820805	Molecular alterations of VanA element in vancomycin-resistant enterococci isolated during a survey of colonized patients in an Italian intensive care unit.	Campanile F, Bartoloni A, Bartalesi F, Borbone S, Mangani V, Mantella A, Nicoletti G, Paradisi F, Russo G, Strohmeyer M, Stefani S	Microb Drug Resist	10.1089/107662903765826796	2003	Adolescent, Adult, Aged, Aged, 80 and over, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Child, DNA, Bacterial/genetics, Data Collection, Electrophoresis, Gel, Pulsed-Field, Enterococcus/drug effects/genetics, Feces/microbiology, Female, Genome, Bacterial, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Infection Control, Intensive Care Units, Italy/epidemiology, Male, Microbial Sensitivity Tests, Middle Aged, Multigene Family/genetics, Polymorphism, Genetic/genetics, Polymorphism, Restriction Fragment Length, Prospective Studies, Reverse Transcriptase Polymerase Chain Reaction, Vancomycin Resistance/genetics	Pathogenicity
Pathogenicity	12888592	Antibiotic activity against urinary tract infection (UTI) isolates of vancomycin-resistant enterococci (VRE): results from the 2002 North American Vancomycin Resistant Enterococci Susceptibility Study (NAVRESS).	Zhanel GG, Laing NM, Nichol KA, Palatnick LP, Noreddin A, Hisanaga T, Johnson JL, Hoban DJ	J Antimicrob Chemother	10.1093/jac/dkg352	2003	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Enterococcus/drug effects/genetics, Humans, Microbial Sensitivity Tests, North America/epidemiology, Phenotype, Reverse Transcriptase Polymerase Chain Reaction, Urinary Tract Infections/epidemiology/microbiology, *Vancomycin Resistance	Metabolism
Pathogenicity	14597000	Occurrence and spread of antibiotic resistances in Enterococcus faecium.	Klare I, Konstabel C, Badstubner D, Werner G, Witte W	Int J Food Microbiol	10.1016/s0168-1605(03)00190-9	2003	Animal Husbandry/methods, Animals, Animals, Domestic, Anti-Bacterial Agents/pharmacology/therapeutic use, Cross Infection, Drug Resistance, Bacterial, Drug Resistance, Multiple, Bacterial, Enterococcus faecium/drug effects/genetics, Food Microbiology, Glycopeptides, Gram-Positive Bacterial Infections/*drug therapy, Humans, Microbial Sensitivity Tests, Vancomycin Resistance/genetics	Biotechnology
Pathogenicity	14617670	Highly conjugative pMG1-like plasmids carrying Tn1546-like transposons that encode vancomycin resistance in Enterococcus faecium.	Tomita H, Tanimoto K, Hayakawa S, Morinaga K, Ezaki K, Oshima H, Ike Y	J Bacteriol	10.1128/JB.185.23.7024-7028.2003	2003	Anti-Bacterial Agents/pharmacology, DNA Transposable Elements, Drug Resistance, Bacterial/genetics, Enterococcus faecium/drug effects/genetics, Humans, Molecular Sequence Data, Plasmids/*genetics/isolation & purification, Vancomycin/pharmacology, Vancomycin Resistance	Genetics
Phylogeny	15071018	Convenient selective differential broth for isolation of vancomycin-resistant enterococcus from fecal material.	Novicki TJ, Schapiro JM, Ulness BK, Sebeste A, Busse-Johnston L, Swanson KM, Swanzy SR, Leisenring W, Limaye AP	J Clin Microbiol	10.1128/JCM.42.4.1637-1640.2004	2004	Anti-Bacterial Agents/pharmacology, Bacteriological Techniques/methods, Culture Media/chemistry, Enterococcus faecium/classification/drug effects/isolation & purification, Feces/microbiology, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Sensitivity and Specificity, Vancomycin/pharmacology, *Vancomycin Resistance	Pathogenicity
Enzymology	15131146	Distribution of insertion sequences associated with Tn1546-like elements among Enterococcus faecium isolates from patients in Korea.	Huh JY, Lee WG, Lee K, Shin WS, Yoo JH	J Clin Microbiol	10.1128/JCM.42.5.1897-1902.2004	2004	Bacterial Proteins/genetics, Base Sequence, Carbon-Oxygen Ligases/genetics, Chromosome Mapping, DNA Primers/genetics, DNA Transposable Elements/genetics, DNA, Bacterial/genetics/isolation & purification, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial, Gram-Positive Bacterial Infections/microbiology, Humans, Korea, Multigene Family, Vancomycin Resistance/genetics	Pathogenicity
Pathogenicity	15334199	Clonal dissemination of VanA-type glycopeptide-resistant Enterococcus faecalis between hospitals of two cities located 100 km apart.	Moretti ML, Bratfich OJ, Stucchi RB, Levi C, Levin AS, Duboc GM, Vormittag E, Blum-Menezes D	Braz J Med Biol Res	10.1590/s0100-879x2004000900008	2004	Anti-Bacterial Agents/therapeutic use, Bacterial Proteins/genetics, Brazil/epidemiology, Carbon-Oxygen Ligases/genetics, Cross Infection/epidemiology/microbiology, Disease Outbreaks, Enterococcus faecalis/genetics/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/*microbiology/transmission, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction, Vancomycin/therapeutic use, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	15471103	Two episodes of vancomycin-resistant Enterococcus faecium outbreaks caused by two genetically different clones in a newborn intensive care unit.	Borgmann S, Niklas DM, Klare I, Zabel LT, Buchenau P, Autenrieth IB, Heeg P	Int J Hyg Environ Health	10.1078/1438-4639-00304	2004	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Cross Infection/epidemiology/genetics/transmission, Disease Outbreaks, Enterococcus faecium/genetics, Female, Germany/epidemiology, Gram-Positive Bacterial Infections/epidemiology/genetics/transmission, Humans, Infant, Newborn, Intensive Care Units, Neonatal, Membrane Proteins/genetics, *Vancomycin Resistance
Pathogenicity	15522003	Emergence of vancomycin-resistant enterococci in a tertiary hospital in Crete, Greece: a cluster of cases and prevalence study on intestinal colonisation.	Christidou A, Gikas A, Scoulica E, Pediaditis J, Roumbelaki M, Georgiladakis A, Tselentis Y	Clin Microbiol Infect	10.1111/j.1469-0691.2004.00992.x	2004	Adult, Aged, Bacterial Proteins/genetics, Carrier State/epidemiology/microbiology, Communicable Diseases, Emerging/epidemiology/microbiology, Enterococcus/classification/drug effects/isolation & purification, Enterococcus faecalis/drug effects, Enterococcus faecium/drug effects, Female, Gram-Positive Bacterial Infections/epidemiology/microbiology, Greece/epidemiology, Hospitals, Humans, Intestines/microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Polymerase Chain Reaction, Prevalence, Vancomycin Resistance/*genetics	Phylogeny
Pathogenicity	15528890	The emergence of glycopeptide-resistant Enterococcus faecium in a university hospital in southwestern Greece.	Kolonitsiou F, Mani V, Parikou H, Trakala M, Dimitracopoulos G, Spiliopoulou I	Chemotherapy	10.1159/000081945	2004	Anti-Bacterial Agents/pharmacology, Cross Infection/microbiology, DNA, Bacterial/genetics, Drug Resistance, Bacterial, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial/drug effects, Genotype, Glycopeptides, Gram-Positive Bacterial Infections/*microbiology, Greece, Hospitals, University, Humans, Microbial Sensitivity Tests, Phenotype, Time Factors	Genetics
Pathogenicity	15552535	[The frequency of resistance to antibiotics of most frequently isolated bacteria from blood cultures during the period 1997-2002].	Mirovic V, Tomanovic B, Konstantinovic S	Vojnosanit Pregl	10.2298/vsp0404391m	2004	Bacteremia/microbiology, Drug Resistance, Bacterial, Humans, Microbial Sensitivity Tests
Pathogenicity	15585502	Antimicrobial susceptibility testing of vancomycin-resistant Enterococcus by the VITEK 2 system, and comparison with two NCCLS reference methods.	Kobayashi I, Muraoka H, Iyoda T, Nishida M, Hasegawa M, Yamaguchi K	J Med Microbiol	10.1099/jmm.0.45765-0	2004	Anti-Bacterial Agents/pharmacology, Automation, Enterococcus/drug effects, Erythromycin/pharmacology, Humans, Microbial Sensitivity Tests/methods, Penicillin G/pharmacology, Reference Standards, Sensitivity and Specificity, Teicoplanin/pharmacology, Vancomycin/pharmacology, *Vancomycin Resistance
Pathogenicity	15644931	Identification of an unusual VanA element in glycopeptide-resistant Enterococcus faecium in Brazil following international transfer of a bone marrow transplant patient.	Camargo IL, Del Peloso PF, Da Costa Leite CF, Goldman GH, Darini AL	Can J Microbiol	10.1139/w04-054	2004	Aged, Bacterial Proteins/genetics, Bone Marrow Transplantation/adverse effects, Brazil, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Enterococcus faecium/classification/drug effects/genetics, Female, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Sequence Analysis, DNA, Transportation of Patients, United States, *Vancomycin Resistance	Genetics
Pathogenicity	15790295	Occurrence of insertion sequences within the genomes and Tn1546-like elements of glycopeptide-resistant enterococci isolated in Brazil, and identification of a novel element, ISEfa5.	Camargo IL, Zanella RC, Brandileone MC, Pignatari AC, Goldman GH, Woodford N, Darini AL	Int J Med Microbiol	10.1016/j.ijmm.2004.11.003	2005	Anti-Bacterial Agents/pharmacology, Brazil, DNA Transposable Elements/genetics, DNA, Bacterial/genetics/isolation & purification, Enterococcus/drug effects/genetics, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial, Glycopeptides, Humans, Vancomycin Resistance/*genetics	Phylogeny
Pathogenicity	15872259	Molecular characterization of vancomycin-resistant Enterococcus faecium isolates from Korea.	Ko KS, Baek JY, Lee JY, Oh WS, Peck KR, Lee N, Lee WG, Lee K, Song JH	J Clin Microbiol	10.1128/JCM.43.5.2303-2306.2005	2005	Bacterial Typing Techniques, Drug Resistance, Bacterial/genetics, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Genotype, Humans, Korea, Phenotype, Polymerase Chain Reaction/methods, Teicoplanin/pharmacology, Vancomycin/*pharmacology	Phylogeny
Pathogenicity	15926119	[Prevalence of vancomycin-resistant enterococci in hospital and community environment.].	Kolar M, Pantucek R, Vagnerova I, Cekanova L, Kesselova M, Sauer P, Koukalova D, Kolar V, Ruzi kova M, Dosar J	Klin Mikrobiol Infekc Lek		2005	Anti-Bacterial Agents/pharmacology, Enterococcus, Humans, Polymerase Chain Reaction, Prevalence, Vancomycin Resistance, Vancomycin-Resistant Enterococci
Genetics	16081891	First nosocomial outbreak of vancomycin-resistant Enterococcus faecium expressing a VanD-like phenotype associated with a vanA genotype.	Naas T, Fortineau N, Snanoudj R, Spicq C, Durrbach A, Nordmann P	J Clin Microbiol	10.1128/JCM.43.8.3642-3649.2005	2005	Adult, Aged, Aged, 80 and over, Bacterial Proteins/analysis/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Cross Infection/epidemiology/microbiology, DNA Transposable Elements, Disease Outbreaks, Enterococcus faecium/classification/drug effects/genetics, Female, Genotype, Humans, Male, Microbial Sensitivity Tests, Middle Aged, Peptide Synthases/analysis, Phenotype, Vancomycin Resistance	Phenotype
Pathogenicity	16091445	Community-acquired vancomycin-resistant Enterococcus faecium: a case report from Malaysia.	Raja NS, Karunakaran R, Ngeow YF, Awang R	J Med Microbiol	10.1099/jmm.0.46169-0	2005	Abscess/microbiology, Adult, Anti-Bacterial Agents/pharmacology, Community-Acquired Infections/microbiology, Enterococcus faecium/drug effects/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Humans, Malaysia, Male, Microbial Sensitivity Tests, Mouth Mucosa/microbiology, *Vancomycin Resistance	Enzymology
Pathogenicity	16157551	Occurrence of vancomycin-resistant enterococci in humans and animals in the Czech Republic between 2002 and 2004.	Kolar M, Pantucek R, Bardon J, Cekanova L, Kesselova M, Sauer P, Vagnerova I, Koukalova D	J Med Microbiol	10.1099/jmm.0.45824-0	2005	Animals, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Carrier State/epidemiology, Cloaca/microbiology, Cluster Analysis, Czech Republic/epidemiology, DNA Fingerprinting, DNA, Bacterial/genetics, Deoxyribonucleases, Type II Site-Specific, Enterococcus/classification/drug effects/genetics/isolation & purification, Genetic Variation, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Peptide Synthases/genetics, Polymorphism, Restriction Fragment Length, Poultry/microbiology, Rectum/microbiology, Vancomycin Resistance/genetics	Phylogeny
Pathogenicity	16190391	[Pathogenic characters of infected bacteria after liver transplantation].	Zhou JD, Zhu SH, Chen Y, Nie XM, Peng HY, Cheng K	Zhong Nan Da Xue Xue Bao Yi Xue Ban		2005	Adolescent, Adult, Aged, Child, Child, Preschool, Drug Resistance, Bacterial/genetics, Enterobacteriaceae/drug effects/enzymology/isolation & purification, Enterobacteriaceae Infections/microbiology, Female, Humans, Infant, Liver Cirrhosis/surgery, Liver Neoplasms/surgery, Liver Transplantation/*adverse effects, Male, Microbial Sensitivity Tests, Middle Aged, Postoperative Complications/microbiology, Retrospective Studies, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	16204568	High prevalence of VanA-type vancomycin-resistant Enterococci in Austrian poultry.	Eisner A, Feierl G, Gorkiewicz G, Dieber F, Kessler HH, Marth E, Kofer J	Appl Environ Microbiol	10.1128/AEM.71.10.6407-6409.2005	2005	Adolescent, Adult, Aged, Aged, 80 and over, Animal Husbandry, Animals, Anti-Bacterial Agents/pharmacology, Austria, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Cattle, Chickens/microbiology, Child, Child, Preschool, Enterococcus/classification/drug effects/genetics/isolation & purification, Feces/microbiology, Female, Humans, Infant, Male, Microbial Sensitivity Tests, Middle Aged, Prevalence, Swine, Vancomycin Resistance	Phylogeny
Phylogeny	16374593	Spread of ampicillin/vancomycin-resistant Enterococcus faecium of the epidemic-virulent clonal complex-17 carrying the genes esp and hyl in German hospitals.	Klare I, Konstabel C, Mueller-Bertling S, Werner G, Strommenger B, Kettlitz C, Borgmann S, Schulte B, Jonas D, Serr A, Fahr AM, Eigner U, Witte W	Eur J Clin Microbiol Infect Dis	10.1007/s10096-005-0056-0	2005	Acetamides/pharmacology, Ampicillin Resistance, Anti-Infective Agents/pharmacology, Bacterial Proteins/genetics, Cross Infection/epidemiology/microbiology, DNA Restriction Enzymes, Drug Resistance, Multiple, Bacterial, Enterococcus faecium/classification/drug effects/genetics/pathogenicity, Germany/epidemiology, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Hyaluronoglucosaminidase/genetics, Linezolid, Membrane Proteins/*genetics, Oxazolidinones/pharmacology, Phenotype, Phylogeny, Polymerase Chain Reaction/methods, Vancomycin Resistance	Pathogenicity
Pathogenicity	16451175	Comparative study of vanA gene transfer from Enterococcus faecium to Enterococcus faecalis and to Enterococcus faecium in the intestine of mice.	Bourgeois-Nicolaos N, Moubareck C, Mangeney N, Butel MJ, Doucet-Populaire F	FEMS Microbiol Lett	10.1111/j.1574-6968.2005.00004.x	2006	Animals, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Conjugation, Genetic, Enterococcus faecalis/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Feces/microbiology, Gene Transfer, Horizontal, Germ-Free Life, Humans, Intestines/*microbiology, Mice, Microbial Sensitivity Tests
Pathogenicity	16504687	Clinical glycopeptide-resistant enterococci isolated from patients after solid organ transplantation.	Sawicka-Grzelak A, Rokosz A, Przybylski M, Kawecki D, Krawczyk E, Rowinski W, Durlik M, Paczek L, Luczak M	Transplant Proc	10.1016/j.transproceed.2005.11.095	2006	Drug Resistance, Enterococcus/drug effects/isolation & purification, Glycopeptides/pharmacology, Humans, Microbial Sensitivity Tests, *Organ Transplantation, Vancomycin/pharmacology	Enzymology
Phylogeny	16524412	Genotypic characterisation of vancomycin-resistant Enterococcus faecium isolates from haemato-oncological patients at Olomouc University Hospital, Czech Republic.	Kolar M, Pantucek R, Vagnerova I, Kesselova M, Sauer P, Matouskova I, Doskar J, Koukalova D, Hejnar P	Clin Microbiol Infect	10.1111/j.1469-0691.2006.01365.x	2006	Cancer Care Facilities, Cross Infection/microbiology, Czech Republic, Enterococcus faecalis/classification/isolation & purification, Enterococcus faecium/classification/genetics/isolation & purification, Genotype, Gram-Positive Bacterial Infections/microbiology, Hematologic Neoplasms, Humans, Neoplasms, Polymorphism, Restriction Fragment Length, Vancomycin Resistance/genetics	Enzymology
Transcriptome	16825401	Sequence analysis of Enterococcus faecium strain 10/96A (VanD4), the original vancomycin-resistant E. faecium strain in Brazil.	Camargo IL, Dalla Costa LM, Woodford N, Gilmore MS, Darini AL	J Clin Microbiol	10.1128/JCM.00509-06	2006	Brazil, Cross Infection/microbiology, DNA, Bacterial/chemistry/genetics, Enterococcus faecium/classification/drug effects/*genetics, Gram-Positive Bacterial Infections/microbiology, Humans, Molecular Epidemiology, Phylogeny, Sequence Analysis, DNA, Vancomycin Resistance	Phylogeny
Pathogenicity	16841552	Prevalence of vancomycin-resistant enterococci in hospitalized patients and those living in the community in the Czech Republic.	Kolar M, Pantucek R, Vagnerova I, Sauer P, Kesselova M, Cekanova L, Koukalova D, Doskar J, Ruzickova V	New Microbiol		2006	Cross Infection/epidemiology/microbiology, Czech Republic/epidemiology, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Microbial Sensitivity Tests, Prevalence, Residence Characteristics, *Vancomycin Resistance	Enzymology
Pathogenicity	16936913	Sources and pathways of spread of vancomycin-resistant enterococci in hemato-oncological patients.	Vagnerova I, Sauer P, Kolar M, Slepickova S, Hubacek J, Faber E, Raida L, Papajik T	Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub	10.5507/bp.2006.017	2006	Cross Infection/microbiology/transmission, Drug Resistance, Bacterial, Enterococcus/classification/drug effects/isolation & purification, Gram-Positive Bacterial Infections/transmission, Hematologic Neoplasms/microbiology, Humans, Teicoplanin/pharmacology, Vancomycin Resistance	Phylogeny
Pathogenicity	17030515	Efficacy of daptomycin in the treatment of experimental endocarditis due to susceptible and multidrug-resistant enterococci.	Vouillamoz J, Moreillon P, Giddey M, Entenza JM	J Antimicrob Chemother	10.1093/jac/dkl406	2006	Amoxicillin/administration & dosage/blood/pharmacology/therapeutic use, Animals, Anti-Bacterial Agents/administration & dosage/blood/pharmacology/therapeutic use, Blood Proteins/metabolism, Daptomycin/administration & dosage/blood/pharmacology/therapeutic use, Disease Models, Animal, Drug Resistance, Multiple, Bacterial, Endocarditis, Bacterial/drug therapy/microbiology, Enterococcus faecalis/drug effects, Enterococcus faecium/drug effects, Female, Microbial Sensitivity Tests, Microbial Viability, Protein Binding, Rats, Rats, Wistar, Teicoplanin/administration & dosage/blood/pharmacology/therapeutic use, Vancomycin/administration & dosage/blood/pharmacology/therapeutic use	Metabolism
Phenotype	17124995	Case report vancomycin -resistant Enterococcus faecium VanA phenotype: first documented isolation in India.	Mohanty S, Dhawan B, Gadepalli RS, Lodha R, Kapil A	Southeast Asian J Trop Med Public Health		2006	Bacterial Proteins, Carbon-Oxygen Ligases, Catheterization/adverse effects, Child, Preschool, Cross Infection, Ductus Arteriosus, Patent/complications, Enterococcus faecium/drug effects/genetics, Equipment Contamination, Fatal Outcome, Female, Gram-Positive Bacterial Infections/diagnosis/microbiology/mortality, Humans, India, Microbial Sensitivity Tests, Phenotype, Sepsis/diagnosis/microbiology/mortality, Vancomycin Resistance/*genetics	Pathogenicity
Pathogenicity	17205686	[Molecular analysis of vancomycin-resistant enterococci isolated from clinical samples].	Kilic A, Senses Z, Aydogan H, Basustaoglu A	Mikrobiyol Bul		2006	Bacteremia/microbiology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Cerebrospinal Fluid/microbiology, DNA, Bacterial/chemistry, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics, Genotype, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, Polymerase Chain Reaction, Turkey, Vancomycin Resistance/genetics	Enzymology
Phylogeny	17220439	Actinomadura rudentiformis sp. nov., isolated from soil.	le Roes M, Meyers PR	Int J Syst Evol Microbiol	10.1099/ijs.0.64438-0	2007	Actinomycetales/classification/genetics/isolation & purification/metabolism, Antibiosis, Bacterial Typing Techniques, DNA, Bacterial/analysis, DNA, Ribosomal/analysis, Enterococcus faecium/drug effects/growth & development, Escherichia coli/drug effects/growth & development, Genes, rRNA, Humans, Microbial Sensitivity Tests, Molecular Sequence Data, Mycobacterium/drug effects/growth & development, Phenotype, Phylogeny, RNA, Ribosomal, 16S/genetics, Sequence Analysis, DNA, Soil Microbiology, South Africa	Pathogenicity
Phylogeny	17351100	VanA-type enterococci from humans, animals, and food: species distribution, population structure, Tn1546 typing and location, and virulence determinants.	Biavasco F, Foglia G, Paoletti C, Zandri G, Magi G, Guaglianone E, Sundsfjord A, Pruzzo C, Donelli G, Facinelli B	Appl Environ Microbiol	10.1128/AEM.02239-06	2007	Animals, Bacterial Proteins/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Carboxy-Lyases/genetics, Chromosomes, Bacterial/genetics, DNA Fingerprinting, DNA Transposable Elements/genetics, DNA, Bacterial/genetics/metabolism, Enterococcus/classification/drug effects/genetics/isolation & purification, Enterococcus faecalis/classification/drug effects/genetics/isolation & purification, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Feces/microbiology, Food Microbiology, Gram-Positive Bacterial Infections/epidemiology/microbiology/transmission/veterinary, Humans, Meat/microbiology, Molecular Epidemiology, Plasmids/genetics, Point Mutation, Polymorphism, Restriction Fragment Length, Poultry, Swine, Vancomycin Resistance/genetics, Virulence Factors/genetics	Pathogenicity
Pathogenicity	17368801	Antimicrobial resistance and molecular epidemiology of vancomycin-resistant enterococci from North America and Europe: a report from the SENTRY antimicrobial surveillance program.	Deshpande LM, Fritsche TR, Moet GJ, Biedenbach DJ, Jones RN	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2006.12.022	2007	Drug Resistance, Multiple, Bacterial/genetics, Enterococcus faecalis/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Europe/epidemiology, Humans, Microbial Sensitivity Tests, Molecular Epidemiology, North America/epidemiology, Sentinel Surveillance, Vancomycin Resistance
Pathogenicity	17561499	Transposon characterization of vancomycin-resistant Enterococcus faecium (VREF) and dissemination of resistance associated with transferable plasmids.	Garcia-Migura L, Liebana E, Jensen LB	J Antimicrob Chemother	10.1093/jac/dkm186	2007	Animals, Blotting, Southern, Chickens/microbiology, DNA Primers, DNA Transposable Elements/genetics, Enterococcus faecium/drug effects/genetics, Gene Transfer, Horizontal, Gram-Positive Bacterial Infections/microbiology/veterinary, Lincosamides, Macrolides/pharmacology, Plasmids/genetics, Poultry Diseases/epidemiology/microbiology, Replicon/genetics, Reverse Transcriptase Polymerase Chain Reaction, Streptogramin B/pharmacology, United Kingdom/epidemiology, Vancomycin Resistance/genetics, Virginiamycin/analogs & derivatives/pharmacology
Pathogenicity	17634295	Molecular characterization of vancomycin-resistant enterococcus faecium isolates from mainland China.	Zheng B, Tomita H, Xiao YH, Wang S, Li Y, Ike Y	J Clin Microbiol	10.1128/JCM.00457-07	2007	Bacterial Typing Techniques/methods, China/epidemiology, Conjugation, Genetic, DNA Transposable Elements/genetics, DNA, Bacterial/chemistry/genetics, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Gene Transfer, Horizontal, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Molecular Epidemiology, Plasmids/genetics, Sequence Analysis, DNA, Vancomycin Resistance/genetics	Phylogeny
Pathogenicity	17718844	The first molecular analysis of clinical isolates of VanA-type vancomycin-resistant Enterococcus faecium strains in Mainland China.	Zheng B, Tomita H, Xiao YH, Ike Y	Lett Appl Microbiol	10.1111/j.1472-765X.2007.02191.x	2007	Anti-Bacterial Agents/metabolism/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, China, DNA Transposable Elements, DNA, Bacterial/metabolism, Enterococcus faecium/drug effects/genetics/isolation & purification, Genes, Bacterial/drug effects, Humans, Models, Genetic, Vancomycin/metabolism/pharmacology, *Vancomycin Resistance	Metabolism
Pathogenicity	17875531	Intensified strategies to control vancomycin-resistant enterococci in immunocompromised patients.	Schmidt-Hieber M, Blau IW, Schwartz S, Uharek L, Weist K, Eckmanns T, Jonas D, Ruden H, Thiel E, Brandt C	Int J Hematol	10.1532/IJH97.E0632	2007	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Disease Outbreaks, Enterococcus/isolation & purification/pathogenicity, Female, Genes, Bacterial, Genotype, Hospital Units, Humans, Immunocompromised Host, Infection Control/methods, Infections/diagnosis/etiology, Lymphoma, Non-Hodgkin/complications, Male, Neoplasms/complications, Vancomycin Resistance	Genetics
Pathogenicity	17933244	[Investigation of phenotypic and genotypic characteristics of vancomycin-resistant Enterococcus faecium isolates].	Aktas Z, Diyarbakirli P, Bal C, Gurler N, Keser M, Somer A, Salman N	Mikrobiyol Bul		2007	Ampicillin/pharmacology, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Drug Resistance, Multiple, Bacterial/genetics/physiology, Enterococcus faecium/classification/drug effects/genetics, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Peptide Synthases/genetics, Phenotype, Polymerase Chain Reaction, Random Amplified Polymorphic DNA Technique, Streptomycin/pharmacology, Teicoplanin/pharmacology, Turkey, Vancomycin Resistance/genetics/physiology	Genetics
Phylogeny	18022008	Significant increase in the isolation of glycopeptide-resistant enterococci from patients hospitalized in the transplant surgery ward in 2004-2005.	Mlynarczyk G, Grzybowska W, Mlynarczyk A, Tyski S, Kawecki D, Luczak M, Chmura A, Rowinski W	Transplant Proc	10.1016/j.transproceed.2007.08.045	2007	Anti-Bacterial Agents/pharmacology, DNA, Bacterial/genetics/isolation & purification, Drug Resistance, Bacterial, Enterococcus/drug effects/isolation & purification, Glycopeptides/pharmacology, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Hospitalization/statistics & numerical data, Humans, Poland, Transplantation/*adverse effects, Vancomycin/therapeutic use	Pathogenicity
Pathogenicity	18424792	In vitro activity of telavancin against recent Gram-positive clinical isolates: results of the 2004-05 Prospective European Surveillance Initiative.	Draghi DC, Benton BM, Krause KM, Thornsberry C, Pillar C, Sahm DF	J Antimicrob Chemother	10.1093/jac/dkn124	2008	Adult, Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Child, Child, Preschool, Europe, Gram-Positive Bacteria/drug effects/isolation & purification, Gram-Positive Bacterial Infections/*microbiology, Humans, Israel, Lipoglycopeptides, Microbial Sensitivity Tests	Enzymology
Enzymology	18440933	Analysis of VanA vancomycin-resistant Enterococcus faecium isolates from Saudi Arabian hospitals reveals the presence of clonal cluster 17 and two new Tn1546 lineage types.	Khan MA, van der Wal M, Farrell DJ, Cossins L, van Belkum A, Alaidan A, Hays JP	J Antimicrob Chemother	10.1093/jac/dkn173	2008	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Cluster Analysis, Conjugation, Genetic, DNA Fingerprinting, DNA Transposable Elements, DNA, Bacterial/chemistry/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification, Gene Order, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, Humans, Hyaluronoglucosaminidase/genetics, Membrane Proteins/genetics, Microbial Sensitivity Tests, Saudi Arabia/epidemiology, Sequence Analysis, DNA, Vancomycin Resistance	Pathogenicity
Enzymology	18592102	Molecular characterization of enterococci harboring genotype and phenotype incongruence related to glycopeptide resistance isolated in Brazilian hospitals.	Henrique PM, Palazzo IC, Zanella RC, Darini AL	Mem Inst Oswaldo Cruz	10.1590/s0074-02762008000300014	2008	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Brazil, Carbon-Oxygen Ligases/genetics, DNA, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Genotype, Humans, Microbial Sensitivity Tests, Phenotype, Polymerase Chain Reaction, Sequence Analysis, DNA, Teicoplanin/pharmacology, Vancomycin/*pharmacology, Vancomycin Resistance/genetics	Pathogenicity
Phylogeny	18609203	Molecular characterization of vancomycin-resistant Enterococcus spp. clinical isolates from Hungary and Serbia.	Libisch B, Lepsanovic Z, Top J, Muzslay M, Konkoly-Thege M, Gacs M, Balogh B, Fuzi M, Willems RJ	Scand J Infect Dis	10.1080/00365540802165740	2008	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Cluster Analysis, Conjugation, Genetic, DNA Fingerprinting, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Humans, Hungary, Membrane Proteins/genetics, Methyltransferases/genetics, Microbial Sensitivity Tests, Minisatellite Repeats, Phylogeny, Polymerase Chain Reaction, Sequence Analysis, DNA, Serbia, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	18646406	Characterization of glycopeptides, aminoglycosides and macrolide resistance among Enterococcus faecalis and Enterococcus faecium isolates from hospitals in Tehran.	Emaneini M, Aligholi M, Aminshahi M	Pol J Microbiol		2008	Acetyltransferases/genetics, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Cross Infection/epidemiology, Disk Diffusion Antimicrobial Tests, Drug Resistance, Bacterial, Enterococcus faecalis/drug effects/enzymology/genetics, Enterococcus faecium/drug effects/enzymology/*genetics, Erythromycin/pharmacology, Genes, Bacterial, Gentamicins/pharmacology, Humans, Iran/epidemiology, Kanamycin Kinase/genetics, Methyltransferases/genetics, Phosphotransferases (Alcohol Group Acceptor)/genetics, Vancomycin/pharmacology, Vancomycin Resistance	Enzymology
Pathogenicity	18792691	Vancomycin resistance VanS/VanR two-component systems.	Hong HJ, Hutchings MI, Buttner MJ	Adv Exp Med Biol	10.1007/978-0-387-78885-2_14	2008	Actinobacteria/drug effects/genetics/physiology, Amino Acid Sequence, Bacterial Proteins/chemistry/genetics/physiology, Enterococcus/drug effects/genetics/pathogenicity/physiology, Genes, Bacterial, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, Molecular Sequence Data, Multigene Family, Peptidyl Transferases/metabolism, Protein Kinases/chemistry/genetics/physiology, Sequence Homology, Amino Acid, Signal Transduction/genetics/physiology, Teicoplanin/pharmacology, Transcription Factors/chemistry/genetics/physiology, Vancomycin Resistance/genetics/physiology	Genetics
Pathogenicity	19021959	Emergence and spread of vancomycin resistance among enterococci in Europe.	Werner G, Coque TM, Hammerum AM, Hope R, Hryniewicz W, Johnson A, Klare I, Kristinsson KG, Leclercq R, Lester CH, Lillie M, Novais C, Olsson-Liljequist B, Peixe LV, Sadowy E, Simonsen GS, Top J, Vuopio-Varkila J, Willems RJ, Witte W, Woodford N	Euro Surveill		2008	Disease Outbreaks/statistics & numerical data, Drug Resistance, Bacterial, Enterococcus/drug effects, Europe/epidemiology, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Humans, Incidence, Population Surveillance, Risk Assessment/methods, Risk Factors, Vancomycin/*therapeutic use
Enzymology	19073301	A new Tn1546 type of VanB phenotype-vanA genotype vancomycin-resistant Enterococcus faecium isolates in mainland China.	Gu L, Cao B, Liu Y, Guo P, Song S, Li R, Dai H, Wang C	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2008.08.018	2009	Anti-Bacterial Agents/therapeutic use, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, China, Drug Resistance, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/genetics/isolation & purification, Gram-Positive Bacterial Infections/drug therapy/microbiology, Hospitals, Humans, Microbial Sensitivity Tests, Polymerase Chain Reaction, Sequence Analysis, DNA, Serotyping, Vancomycin Resistance/genetics	Pathogenicity
Phylogeny	19243566	Classification and antimicrobial susceptibilities of enterococcus species isolated from apparently healthy food-producing animals in Japan.	Kojima A, Morioka A, Kijima M, Ishihara K, Asai T, Fujisawa T, Tamura Y, Takahashi T	Zoonoses Public Health	10.1111/j.1863-2378.2008.01204.x	2009	Animal Husbandry/methods, Animals, Anti-Bacterial Agents/pharmacology, Cattle, Chickens, Colony Count, Microbial, Dose-Response Relationship, Drug, Drug Resistance, Bacterial, Enterococcus/classification/drug effects/isolation & purification, Enterococcus faecalis/classification/drug effects/isolation & purification, Enterococcus faecium/classification/drug effects/isolation & purification, Food Contamination/prevention & control, Gram-Positive Bacterial Infections/transmission/veterinary, Humans, Japan, Microbial Sensitivity Tests, Phylogeny, Swine, Zoonoses	Pathogenicity
Pathogenicity	19369269	Time-kill kinetics of oritavancin and comparator agents against Staphylococcus aureus, Enterococcus faecalis and Enterococcus faecium.	McKay GA, Beaulieu S, Arhin FF, Belley A, Sarmiento I, Parr T Jr, Moeck G	J Antimicrob Chemother	10.1093/jac/dkp126	2009	Anti-Bacterial Agents/pharmacology, Dose-Response Relationship, Drug, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Glycopeptides/pharmacology, Gram-Positive Bacterial Infections/microbiology, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Microbial Viability, Staphylococcal Infections/microbiology, Staphylococcus aureus/*drug effects/isolation & purification, Time Factors	Enzymology
Phylogeny	19477606	[Glycopeptide-resistant enterococci carriage: Are actual isolation and identification techniques sufficient?].	Surcouf C, Fabre M, Enouf V, Cade S, Soler C, Mac Nab C, Samson T, Foissaud V	Pathol Biol (Paris)	10.1016/j.patbio.2009.04.004	2009	Aged, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Bacteriological Techniques, Carbon-Oxygen Ligases/genetics, Carrier State/microbiology, Cross Infection/microbiology, Drug Resistance, Multiple, Bacterial/genetics, Enterococcus/classification/drug effects/genetics/growth & development/isolation & purification, Feces/microbiology, Female, France, Glycopeptides/pharmacology, Gram-Positive Bacterial Infections/diagnosis/microbiology, Hospital Units, Humans, Male, Mass Screening/methods, Middle Aged, Peptide Synthases/genetics, *Reagent Kits, Diagnostic, Rectum/microbiology, Species Specificity, Vancomycin/pharmacology, Vancomycin Resistance/genetics, Young Adult	Pathogenicity
Phylogeny	19502306	Streptomyces polyantibioticus sp. nov., isolated from the banks of a river.	le Roes-Hill M, Meyers PR	Int J Syst Evol Microbiol	10.1099/ijs.0.006171-0	2009	Antibiosis, Bacterial Typing Techniques, DNA, Bacterial/analysis, DNA, Ribosomal/analysis, Fatty Acids/analysis, Gram-Negative Bacteria/growth & development, Gram-Positive Bacteria/growth & development, Microbial Sensitivity Tests/methods, Molecular Sequence Data, Phenotype, Phylogeny, RNA, Ribosomal, 16S/genetics, Rivers, Sequence Analysis, DNA, Soil Microbiology, South Africa, Species Specificity, Streptomyces/*classification/genetics/isolation & purification/physiology	Genetics
Enzymology	19622078	High prevalence of ST-78 infection-associated vancomycin-resistant Enterococcus faecium from hospitals in Asuncion, Paraguay.	Khan MA, Northwood JB, Loor RG, Tholen AT, Riera E, Falcon M, van Belkum A, van Westreenen M, Hays JP	Clin Microbiol Infect	10.1111/j.1469-0691.2009.02898.x	2009	Bacterial Proteins/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Cluster Analysis, Cross Infection/epidemiology/microbiology, DNA Fingerprinting, DNA Transposable Elements, DNA, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/isolation & purification, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospitals, Humans, Paraguay/epidemiology, Prevalence, Sequence Analysis, DNA, Vancomycin Resistance	Pathogenicity
Pathogenicity	19623898	[Vancomycin-resistant enterococci: prevalence and factors associated with intestinal colonization in oncology patients from Hospital de Ninos de Cordoba].	Reale AL, Depetri ML, Culasso C, Paviolo M, Cheguirian ML, Enrico MC, Ledesma EM, Vidal C, Glatstein E, Bertoni L	Rev Argent Microbiol	S0325-75412009000200006	2009	Adolescent, Anti-Bacterial Agents/pharmacology, Argentina/epidemiology, Child, Child, Preschool, Cross Infection/prevention & control, Drug Resistance, Multiple, Bacterial, Enterococcus/drug effects/isolation & purification, Female, Gram-Positive Bacterial Infections/prevention & control, Hospitals, Pediatric, Humans, Immunocompromised Host, Infant, Infant, Newborn, Intestines/microbiology, Male, Neoplasms/microbiology, Neutropenia/microbiology, Prevalence, Risk Factors, Vancomycin Resistance	Enzymology
Enzymology	19694552	vanA in Enterococcus faecium, Enterococcus faecalis, and Enterococcus casseliflavus detected in French cattle.	Haenni M, Saras E, Chatre P, Meunier D, Martin S, Lepage G, Menard MF, Lebreton P, Rambaud T, Madec JY	Foodborne Pathog Dis	10.1089/fpd.2009.0303	2009	Animal Husbandry/legislation & jurisprudence/methods, Animals, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Cattle/microbiology, Cattle Diseases/epidemiology/microbiology, Electrophoresis, Gel, Pulsed-Field, Enterococcus/drug effects/genetics/isolation & purification, Enterococcus faecalis/isolation & purification, Enterococcus faecium/isolation & purification, Feces/microbiology, Foodborne Diseases/prevention & control, France/epidemiology, Gene Transfer, Horizontal, Genotype, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology/veterinary, Microbial Sensitivity Tests, Peptide Synthases/genetics/metabolism, Phenotype, Vancomycin Resistance/*genetics	Metabolism
Pathogenicity	19738026	Comparative in vitro activity profile of oritavancin against recent gram-positive clinical isolates.	Arhin FF, Draghi DC, Pillar CM, Parr TR Jr, Moeck G, Sahm DF	Antimicrob Agents Chemother	10.1128/AAC.00952-09	2009	Anti-Bacterial Agents/pharmacology, Drug Resistance, Bacterial, Enterococcus faecium/drug effects, Glycopeptides/pharmacology, Gram-Positive Bacteria/*drug effects, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Staphylococcus aureus/drug effects, Streptococcus/drug effects
Phylogeny	20084906	[First isolation and detection of multiple clones of vancomycin-resistant enterococci in the pediatric unit of Van Yuzuncu Yil University Turkey].	Guducuoglu H, Aktas E, Begendik Comert F, Aygul K, Ozlu N, Baykal S, Berktas M, Ceylan A	Mikrobiyol Bul		2009	Adolescent, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Child, Child, Preschool, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Female, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Infant, Infant, Newborn, Male, Rectum/microbiology, Skin/microbiology, Turkey, *Vancomycin Resistance/genetics	Enzymology
Enzymology	20170984	Characterisation of vancomycin-resistant enterococci from hospitalised patients at a tertiary centre over a seven-year period.	Chang CM, Wang LR, Lee HC, Lee NY, Wu CJ, Ko WC	J Hosp Infect	10.1016/j.jhin.2009.10.025	2010	Bacterial Proteins/genetics, Bacterial Typing Techniques, Carbon-Oxygen Ligases/genetics, Cluster Analysis, DNA Fingerprinting, DNA, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecalis/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Membrane Proteins/genetics, Molecular Epidemiology, Taiwan/epidemiology, *Vancomycin Resistance, Virulence Factors/genetics	Pathogenicity
Pathogenicity	20185550	Analysis of methods commonly used for glycopeptide and oxazolidinone susceptibility testing in Enterococcus faecium isolates.	Raponi G, Ghezzi MC, Gherardi G, Lorino G, Dicuonzo G	J Med Microbiol	10.1099/jmm.0.016444-0	2010	Acetamides/pharmacology, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA, Bacterial/genetics, Enterococcus faecium/drug effects, Glycopeptides/pharmacology, Humans, Linezolid, Microbial Sensitivity Tests/methods, Oxazolidinones/pharmacology, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, RNA, Ribosomal, 23S/genetics, Teicoplanin/pharmacology, Vancomycin/pharmacology
Pathogenicity	20207140	Synthesis, crystal and antibacterial studies of diversely functionalized tetrahydropyridin-4-ol.	Aridoss G, Amirthaganesan S, Jeong YT	Bioorg Med Chem Lett	10.1016/j.bmcl.2010.02.015	2010	Anti-Bacterial Agents/chemical synthesis/chemistry/pharmacology, Bacteria/drug effects, Bacterial Infections/drug therapy, Crystallography, X-Ray, Humans, Microbial Sensitivity Tests, Models, Molecular, Pyridines/chemical synthesis/chemistry/*pharmacology
Phylogeny	20237442	Characterization of vancomycin-resistant Enterococcus isolates from broilers in Selangor, Malaysia.	Getachew YM, Hassan L, Zakaria Z, Saleha AA, Kamaruddin MI, Che Zalina MZ	Trop Biomed		2009	Animals, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Chickens/microbiology, DNA, Bacterial/analysis, Enterococcus/classification/drug effects/genetics/isolation & purification, Genetic Variation, Malaysia, Microbial Sensitivity Tests, Polymerase Chain Reaction, Vancomycin/pharmacology, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	20558469	Tn1546 is part of a larger plasmid-encoded genetic unit horizontally disseminated among clonal Enterococcus faecium lineages.	Sletvold H, Johnsen PJ, Wikmark OG, Simonsen GS, Sundsfjord A, Nielsen KM	J Antimicrob Chemother	10.1093/jac/dkq219	2010	Amino Acid Sequence, Animals, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Chromosome Walking, Cluster Analysis, DNA Primers/genetics, DNA Transposable Elements, DNA, Bacterial/chemistry/genetics, Enterococcus faecium/genetics/isolation & purification, France, Gene Order, Gene Transfer, Horizontal, Gram-Positive Bacterial Infections/microbiology/veterinary, Humans, Models, Molecular, Molecular Sequence Data, Nucleic Acid Conformation, Plasmids, Sequence Alignment, Sequence Analysis, DNA, Sequence Homology	Genetics
Enzymology	20733041	vanM, a new glycopeptide resistance gene cluster found in Enterococcus faecium.	Xu X, Lin D, Yan G, Ye X, Wu S, Guo Y, Zhu D, Hu F, Zhang Y, Wang F, Jacoby GA, Wang M	Antimicrob Agents Chemother	10.1128/AAC.01710-09	2010	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Chromatography, Liquid, Drug Resistance, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics, Glycopeptides/*pharmacology, Mass Spectrometry, Microbial Sensitivity Tests, Molecular Sequence Data, Multigene Family/genetics/physiology, Polymerase Chain Reaction	Genetics
Pathogenicity	20739492	Evaluation of BBL CHROMagar VanRE for detection of vancomycin-resistant Enterococci in rectal swab specimens.	Stamper PD, Shulder S, Bekalo P, Manandhar D, Ross TL, Speser S, Kingery J, Carroll KC	J Clin Microbiol	10.1128/JCM.01522-10	2010	Anti-Bacterial Agents/pharmacology, Azides/metabolism, Bile/metabolism, Culture Media/chemistry, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Esculin/metabolism, Humans, Microbial Sensitivity Tests/methods, Predictive Value of Tests, Rectum/microbiology, Sensitivity and Specificity, Vancomycin/pharmacology, *Vancomycin Resistance	Metabolism
Pathogenicity	20846936	Telavancin activity against Gram-positive bacteria isolated from respiratory tract specimens of patients with nosocomial pneumonia.	Pfaller MA, Mendes RE, Sader HS, Jones RN	J Antimicrob Chemother	10.1093/jac/dkq335	2010	Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Asia, Cross Infection/microbiology, Culture Media/chemistry, Europe, Gram-Positive Bacteria/drug effects/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Humans, Latin America, Lipoglycopeptides, Microbial Sensitivity Tests, North America, Pacific Islands, Pneumonia, Bacterial/microbiology, Respiratory System/microbiology, United States	Cultivation
	20858227	Proteomic characterization of vanA-containing Enterococcus recovered from Seagulls at the Berlengas Natural Reserve, W Portugal.	Radhouani H, Poeta P, Pinto L, Miranda J, Coelho C, Carvalho C, Rodrigues J, Lopez M, Torres C, Vitorino R, Domingues P, Igrejas G	Proteome Sci	10.1186/1477-5956-8-48	2010
Pathogenicity	21234755	Vancomycin-resistance transferability from VanA enterococci to Staphylococcus aureus.	de Niederhausern S, Bondi M, Messi P, Iseppi R, Sabia C, Manicardi G, Anacarso I	Curr Microbiol	10.1007/s00284-011-9868-6	2011	Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Conjugation, Genetic, Enterococcus/drug effects/enzymology/genetics, Gene Transfer, Horizontal, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Staphylococcal Infections/microbiology, Staphylococcus aureus/drug effects/*genetics, Vancomycin/pharmacology, Vancomycin Resistance	Metabolism
Enzymology	21709077	Genetic organization and mode of action of a novel bacteriocin, bacteriocin 51: determinant of VanA-type vancomycin-resistant Enterococcus faecium.	Yamashita H, Tomita H, Inoue T, Ike Y	Antimicrob Agents Chemother	10.1128/AAC.01274-10	2011	Bacterial Proteins/genetics, Bacteriocins/genetics, Blotting, Northern, Electrophoresis, Gel, Pulsed-Field, Electrophoresis, Polyacrylamide Gel, Enterococcus faecium/*genetics, Polymerase Chain Reaction, Sequence Analysis, DNA, Vancomycin Resistance	Transcriptome
Enzymology	21741112	Changes in vancomycin-resistant Enterococcus faecium causing outbreaks in Brazil.	Palazzo IC, Pitondo-Silva A, Levy CE, da Costa Darini AL	J Hosp Infect	10.1016/j.jhin.2011.04.016	2011	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Brazil/epidemiology, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Molecular Typing, Multilocus Sequence Typing, Polymorphism, Genetic, Protein Kinases/genetics, Transcription Factors/genetics, Vancomycin/pharmacology, *Vancomycin Resistance	Pathogenicity
Metabolism	21940270	Resistance patterns and occurrence of virulence determinants among GRE strains in southwestern Poland.	Kowalska-Krochmal B, Dworniczek E, Dolna I, Bania J, Walecka E, Seniuk A, Gosciniak G	Adv Med Sci	10.2478/v10039-011-0022-2	2011	Acetamides/pharmacology, Agar/chemistry, Anti-Bacterial Agents/pharmacology, Biofilms, Daptomycin/pharmacology, Deoxyribonucleases/metabolism, Drug Resistance, Drug Resistance, Bacterial, Enterococcus/genetics/*metabolism, Gelatinases/metabolism, Glycopeptides/chemistry, Hemolysin Proteins/metabolism, Hospitalization, Humans, Linezolid, Lipase/metabolism, Minocycline/analogs & derivatives/pharmacology, Norfloxacin/pharmacology, Oxazolidinones/pharmacology, Phenotype, Poland, Tigecycline, Virulence	Pathogenicity
Pathogenicity	22097115	[Frequency of vancomycin-resistant enterococci isolated from blood cultures from 2008 to 2010].	Mihajlovic Ukropina M, Jelesic Z, Gusman V, Milosavljevic B	Med Pregl	10.2298/mpns1110481m	2011	Bacteremia/microbiology, Drug Resistance, Bacterial, Enterococcus/drug effects/isolation & purification, Humans, *Vancomycin Resistance	Enzymology
Pathogenicity	22124681	Efficiency of the Cepheid Xpert vanA/vanB assay for screening of colonization with vancomycin-resistant enterococci during hospital outbreak.	Zabicka D, Strzelecki J, Wozniak A, Strzelecki P, Sadowy E, Kuch A, Hryniewicz W	Antonie Van Leeuwenhoek	10.1007/s10482-011-9681-z	2011	Bacterial Proteins/genetics, Bacteriological Techniques, Cancer Care Facilities, Carbon-Oxygen Ligases/genetics, Carrier State/epidemiology/microbiology, Chromogenic Compounds, Cross Infection/epidemiology/microbiology, DNA, Bacterial/analysis/genetics, Disease Outbreaks, Enterococcus faecium/drug effects/enzymology/genetics/isolation & purification, Feces/microbiology, Gastroenterology, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hematology, Hospital Units, Humans, Mass Screening, Poland/epidemiology, Predictive Value of Tests, Real-Time Polymerase Chain Reaction/methods, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	22431854	Unmet needs and prospects for oritavancin in the management of vancomycin-resistant enterococcal infections.	Arias CA, Mendes RE, Stilwell MG, Jones RN, Murray BE	Clin Infect Dis	10.1093/cid/cir924	2012	Animals, Anti-Bacterial Agents/pharmacology, Colony Count, Microbial, Disease Models, Animal, Drug Resistance, Multiple, Bacterial, Drug Therapy, Combination, Enterococcus/drug effects, Glycopeptides/pharmacology, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Rabbits, Rats, Vancomycin Resistance
Pathogenicity	22619881	Vancomycin-resistant enterococci (VRE) isolates isolated in Rajavithi Hospital between 1999 and 2009.	Thongkoom P, Kanjanahareutai S, Chantrakooptungool S, Rahule S	J Med Assoc Thai		2012	Cross Infection/drug therapy/microbiology, Enterococcus/drug effects/isolation & purification, Humans, Microbial Sensitivity Tests, Phenotype, Thailand, *Vancomycin Resistance	Phylogeny
Pathogenicity	22627577	Polyclonal outbreak of vancomycin-resistant Enterococcus faecium in a pediatric oncology department.	Iosifidis E, Karakoula K, Protonotariou E, Kaperoni M, Matapa E, Pournaras S, Koliouskas D, Sofianou D, Roilides E	J Pediatr Hematol Oncol	10.1097/MPH.0b013e318257a5d3	2012	Case-Control Studies, Child, Cross Infection/drug therapy/epidemiology, Disease Outbreaks, Enterococcus faecium/drug effects, Gram-Positive Bacterial Infections/drug therapy/epidemiology, Humans, Medical Oncology, Retrospective Studies, *Vancomycin Resistance
Enzymology	22953740	Antimicrobial resistance profiles of Enterococcus faecalis and Enterococcus faecium isolated from artisanal food of animal origin in Argentina.	Delpech G, Pourcel G, Schell C, De Luca M, Basualdo J, Bernstein J, Grenovero S, Sparo M	Foodborne Pathog Dis	10.1089/fpd.2012.1192	2012	Animals, Anti-Bacterial Agents/pharmacology, Argentina, Bacterial Proteins/genetics/isolation & purification/metabolism, Carbon-Oxygen Ligases/genetics/isolation & purification/metabolism, Cattle, Ciprofloxacin/pharmacology, Dairy Products/microbiology, Drug Resistance, Multiple, Bacterial, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Food Contamination/analysis, Food Microbiology, Genotype, Gentamicins/pharmacology, Goats, Meat Products/microbiology, Microbial Sensitivity Tests, Penicillins/pharmacology, Phenotype, Streptomycin/pharmacology, Teicoplanin/pharmacology, Vancomycin/pharmacology, beta-Lactamases/metabolism	Phylogeny
Pathogenicity	23298432	In vitro activity of telavancin and comparators against selected groups of Gram-positive cocci.	Hope R, Chaudhry A, Adkin R, Livermore DM	Int J Antimicrob Agents	10.1016/j.ijantimicag.2012.10.016	2013	Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Enterococcus/drug effects/isolation & purification, Gram-Positive Cocci/drug effects/isolation & purification, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Staphylococcus/drug effects/isolation & purification, Streptococcus/drug effects/isolation & purification	Enzymology
	23400108	High frequency of vancomycin-resistant enterococcus faecalis in an Iranian referral children medical hospital.	Pourakbari B, Aghdam MK, Mahmoudi S, Ashtiani MT, Sabouni F, Movahedi Z, Alyari AE, Sadeghi RH, Mamishi S	Maedica (Bucur)		2012
Genetics	23429076	Clinical and microbiological characteristics of vancomycin-resistant enterococci with the VanD phenotype and vanA genotype.	Song JY, Cheong HJ, Seo YB, Kim IS, Heo JY, Noh JY, Choi WS, Kim WJ	Jpn J Infect Dis	10.7883/yoken.66.1	2013	Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Case-Control Studies, Enterococcus faecium/drug effects/genetics/isolation & purification, Female, Genotype, Gram-Positive Bacterial Infections/microbiology, Hospitals, University, Humans, Intensive Care Units, Male, Microbial Sensitivity Tests, Middle Aged, Peptide Synthases/genetics, Phenotype, Retrospective Studies, Risk Factors, Teicoplanin/pharmacology, Vancomycin/pharmacology, Vancomycin Resistance/*genetics, Virulence Factors/genetics	Phenotype
Phenotype	23844821	Diversity of Tn1546 in vanA-positive Enterococcus faecium clinical isolates with VanA, VanB, and VanD phenotypes and susceptibility to vancomycin.	Cha JO, Yoo JI, Kim HK, Kim HS, Yoo JS, Lee YS, Jung YH	J Appl Microbiol	10.1111/jam.12300	2013	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Hospitals, Humans, Peptide Synthases/genetics, Phenotype, Vancomycin Resistance/*genetics	Pathogenicity
Metabolism	24397493	Functional motions modulating VanA ligand binding unraveled by self-organizing maps.	Bouvier G, Duclert-Savatier N, Desdouits N, Meziane-Cherif D, Blondel A, Courvalin P, Nilges M, Malliavin TE	J Chem Inf Model	10.1021/ci400354b	2014	Artificial Intelligence, Bacterial Proteins/chemistry/metabolism, Carbon-Oxygen Ligases/chemistry/metabolism, Catalytic Domain, Computational Biology, Crystallography, X-Ray, Drug Design, Enterococcus faecium/enzymology, Ligands, *Models, Molecular, Molecular Dynamics Simulation, Protein Conformation, Software, Vancomycin Resistance	Enzymology
Pathogenicity	24463723	Molecular characteristics of vancomycin-resistant Enterococcus faecium from a tertiary care hospital in Chengdu, China: molecular characteristics of VRE in China.	Kang M, Xie Y, He C, Chen ZX, Guo L, Yang Q, Liu JY, Du Y, Ou QS, Wang LL	Eur J Clin Microbiol Infect Dis	10.1007/s10096-013-2029-z	2014	Adhesins, Bacterial/genetics, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, China, Cross Infection/microbiology, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Hyaluronoglucosaminidase/genetics, Membrane Proteins/genetics, Microbial Sensitivity Tests, Multilocus Sequence Typing, Phenotype, Polymerase Chain Reaction, Tertiary Care Centers, *Vancomycin Resistance, Virulence Factors/genetics	Phylogeny
Pathogenicity	24968036	[In vitro antimicrobial susceptibility in Enterococcus faecalis and Enterococcus faecium isolated from hospitalized patients].	Medell M, Hart M, Batista ML	Biomedica	10.1590/S0120-41572014000500007	2014	Acetamides/pharmacology, Bacterial Typing Techniques, Cross Infection/epidemiology/microbiology, Cuba/epidemiology, Drug Resistance, Multiple, Bacterial, Enterococcus faecalis/drug effects/isolation & purification, Enterococcus faecium/drug effects/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/*microbiology, Hospitals, Urban/statistics & numerical data, Humans, Linezolid, Microbial Sensitivity Tests, Oxazolidinones/pharmacology, Tertiary Care Centers/statistics & numerical data, Vancomycin Resistance	Enzymology
Pathogenicity	25362568	Activity of oritavancin against Gram-positive clinical isolates responsible for documented skin and soft-tissue infections in European and US hospitals (2010-13).	Mendes RE, Farrell DJ, Sader HS, Flamm RK, Jones RN	J Antimicrob Chemother	10.1093/jac/dku421	2014	Anti-Bacterial Agents/pharmacology, Cross Infection/epidemiology/microbiology, Drug Resistance, Bacterial, Europe/epidemiology, Glycopeptides/pharmacology, Gram-Positive Bacteria/classification/drug effects/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Public Health Surveillance, Skin Diseases, Bacterial/epidemiology/microbiology, Soft Tissue Infections/epidemiology/*microbiology, United States/epidemiology	Phylogeny
Proteome	25449832	Effect of vancomycin on the proteome of the multiresistant Enterococcus faecium SU18 strain.	Ramos S, Chafsey I, Silva N, Hebraud M, Santos H, Capelo-Martinez JL, Poeta P, Igrejas G	J Proteomics	10.1016/j.jprot.2014.10.012	2014	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/biosynthesis/genetics, Drug Resistance, Multiple, Bacterial/drug effects/genetics, Enterococcus faecium/genetics/metabolism, Gene Expression Regulation, Bacterial/drug effects/genetics, Proteome/biosynthesis/genetics, Vancomycin/*pharmacology	Pathogenicity
	25584223	Neonatal septicaemia caused by vancomycin resistant enterococcus faecium-a case report.	Gb S, T N, Dr P, Tr H, R K	J Clin Diagn Res	10.7860/JCDR/2014/10284.5220	2014
Phylogeny	25588068	Different VanA Elements in E. faecalis and in E. faecium Suggest at Least Two Origins of Tn1546 Among VRE in a Brazilian Hospital.	Merlo TP, Dabul AN, Camargo IL	Microb Drug Resist	10.1089/mdr.2014.0077	2015	Ampicillin/pharmacology, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Brazil/epidemiology, Carbon-Oxygen Ligases/genetics/metabolism, Clone Cells, Cross Infection/drug therapy/epidemiology/microbiology, DNA Mutational Analysis, DNA Transposable Elements, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecalis/classification/drug effects/genetics/isolation & purification, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Gene Expression Regulation, Bacterial, Genetic Variation, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology, Hospitals, Humans, Microbial Sensitivity Tests, Penicillins/pharmacology, Phylogeny, Plasmids/chemistry/metabolism, Vancomycin/pharmacology, Vancomycin Resistance/genetics	Enzymology
Enzymology	25618421	Update of the telavancin activity in vitro tested against a worldwide collection of Gram-positive clinical isolates (2013), when applying the revised susceptibility testing method.	Mendes RE, Farrell DJ, Sader HS, Streit JM, Jones RN	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2014.12.011	2014	Americas, Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Asia, Europe, Global Health, Gram-Positive Bacteria/drug effects/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Lipoglycopeptides, Microbial Sensitivity Tests, United States	Phylogeny
	25664041	Investigation of vancomycin resistant Enterococcus faecium outbreak in neonatal intensive care unit.	Cilo BD, Agca H, Efe K, Sinirtas M, Celebi S, Ozkan H, Koksal N, Hacimustafaoglu M, Ozakin C	Int J Clin Exp Med		2014
Pathogenicity	25976380	Molecular characterization of resistance, virulence and clonality in vancomycin-resistant Enterococcus faecium and Enterococcus faecalis: A hospital-based study in Beijing, China.	Yang JX, Li T, Ning YZ, Shao DH, Liu J, Wang SQ, Liang GW	Infect Genet Evol	10.1016/j.meegid.2015.05.012	2015	Cross Infection, Enterococcus faecalis/classification/drug effects/genetics/pathogenicity, Enterococcus faecium/classification/drug effects/genetics/pathogenicity, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Multilocus Sequence Typing, Vancomycin Resistance/genetics, Virulence/genetics	Phylogeny
Pathogenicity	26058844	Telavancin activity tested against Gram-positive clinical isolates from European, Russian and Israeli hospitals (2011-2013) using a revised broth microdilution testing method: redefining the baseline activity of telavancin.	Mendes RE, Flamm RK, Farrell DJ, Sader HS, Jones RN	J Chemother	10.1179/1973947815Y.0000000050	2016	Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Europe, Gram-Positive Bacteria/*drug effects/isolation & purification, Gram-Positive Bacterial Infections/microbiology, Hospitals, Humans, Israel, Lipoglycopeptides, Microbial Sensitivity Tests/methods, Russia	Enzymology
Metabolism	27270282	Substrate Inhibition of VanA by d-Alanine Reduces Vancomycin Resistance in a VanX-Dependent Manner.	van der Aart LT, Lemmens N, van Wamel WJ, van Wezel GP	Antimicrob Agents Chemother	10.1128/AAC.00276-16	2016	Alanine/metabolism, Anti-Bacterial Agents/pharmacology, Bacterial Proteins/metabolism, Carbon-Oxygen Ligases/metabolism, Cell Wall/drug effects/metabolism, Drug Resistance, Microbial/drug effects, Enterococcus faecium/drug effects/metabolism, Glycopeptides/metabolism, Ligases/metabolism, Peptidoglycan/metabolism, Serine-Type D-Ala-D-Ala Carboxypeptidase/metabolism, Streptomyces coelicolor/drug effects/metabolism, Vancomycin/pharmacology, Vancomycin Resistance/drug effects	Pathogenicity
Pathogenicity	27351410	Characteristics of Vancomycin-Resistant Enterococcus Strains in the West Balkans: A First Report.	Jakovac S, Bojic EF, Ibrisimovic MA, Tutis B, Ostojic M, Hukic M	Microb Drug Resist	10.1089/mdr.2015.0355	2016	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Bacterial Typing Techniques, Bosnia and Herzegovina/epidemiology, Carbon-Oxygen Ligases/genetics/metabolism, Croatia/epidemiology, Enterococcus faecalis/drug effects/genetics/growth & development/isolation & purification, Enterococcus faecium/drug effects/genetics/growth & development/isolation & purification, Gene Expression Regulation, Bacterial, Gene Transfer, Horizontal, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology/transmission, Humans, Microbial Sensitivity Tests, Pilot Projects, Plasmids/chemistry/metabolism, Prospective Studies, Public Health Surveillance, Vancomycin/pharmacology, Vancomycin Resistance/genetics, Vancomycin-Resistant Enterococci/drug effects/genetics/growth & development/isolation & purification	Metabolism
Enzymology	27530756	Multilevel population genetic analysis of vanA and vanB Enterococcus faecium causing nosocomial outbreaks in 27 countries (1986-2012).	Freitas AR, Tedim AP, Francia MV, Jensen LB, Novais C, Peixe L, Sanchez-Valenzuela A, Sundsfjord A, Hegstad K, Werner G, Sadowy E, Hammerum AM, Garcia-Migura L, Willems RJ, Baquero F, Coque TM	J Antimicrob Chemother	10.1093/jac/dkw312	2016	Bacterial Proteins/genetics, Bacteriocins/analysis, Carbon-Oxygen Ligases/genetics, Cross Infection/epidemiology/microbiology, DNA Transposable Elements, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/genetics/isolation & purification, Gene Transfer, Horizontal, Genetic Variation, Genetics, Population, Genotype, Global Health, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Multilocus Sequence Typing, Plasmids/analysis, Vancomycin-Resistant Enterococci/*classification/genetics/isolation & purification, Virulence Factors/genetics	Phylogeny
Pathogenicity	27609052	Longitudinal (2001-14) analysis of enterococci and VRE causing invasive infections in European and US hospitals, including a contemporary (2010-13) analysis of oritavancin in vitro potency.	Mendes RE, Castanheira M, Farrell DJ, Flamm RK, Sader HS, Jones RN	J Antimicrob Chemother	10.1093/jac/dkw319	2016	Anti-Bacterial Agents/pharmacology, Bacteremia/epidemiology/microbiology, Cross Infection/epidemiology/microbiology, Enterococcus/drug effects/isolation & purification, Europe, Glycopeptides/pharmacology, Hospitals, Humans, Lipoglycopeptides, Longitudinal Studies, Microbial Sensitivity Tests, Prevalence, United States, Vancomycin Resistance	Enzymology
Metabolism	27611478	Incorporation of a Valine-Leucine-Lysine-Containing Substrate in the Bacterial Cell Wall.	Hansenova Manaskova S, Bikker FJ, Nazmi K, van Zuidam R, Slotman JA, van Cappellen WA, Houtsmuller AB, Veerman EC, Kaman WE	Bioconjug Chem	10.1021/acs.bioconjchem.6b00381	2016	Amino Acid Motifs, Aminoacyltransferases/genetics/metabolism, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/metabolism, Cell Wall/chemistry/metabolism, Cysteine Endopeptidases/genetics/metabolism, Enterococcus faecium/cytology/drug effects/metabolism, Gram-Positive Bacteria/cytology/metabolism, Leucine/chemistry, Lysine/chemistry, Microbial Sensitivity Tests, Peptides/*pharmacokinetics, Staphylococcus aureus/cytology/genetics, Valine/chemistry	Pathogenicity
Phylogeny	27752789	Diversity of plasmids and Tn1546-type transposons among VanA Enterococcus faecium in Poland.	Wardal E, Kuch A, Gawryszewska I, Zabicka D, Hryniewicz W, Sadowy E	Eur J Clin Microbiol Infect Dis	10.1007/s10096-016-2804-8	2016	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Enterococcus faecium/genetics/isolation & purification, Evolution, Molecular, Genetic Variation, Genotyping Techniques, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Molecular Typing, Nucleic Acid Hybridization, Plasmids, Poland, Polymerase Chain Reaction, Sequence Analysis, DNA	Pathogenicity
Enzymology	27852447	A polyclonal outbreak of bloodstream infections by Enterococcus faecium in patients with hematologic malignancies.	Alatorre-Fernandez P, Mayoral-Teran C, Velazquez-Acosta C, Franco-Rodriguez C, Flores-Moreno K, Cevallos MA, Lopez-Vidal Y, Volkow-Fernandez P	Am J Infect Control	10.1016/j.ajic.2016.10.002	2016	Adolescent, Adult, Case-Control Studies, DNA, Bacterial/genetics, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/genetics/isolation & purification, Female, Genetic Variation, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hematologic Neoplasms/complications, Humans, Male, Middle Aged, Molecular Epidemiology, Molecular Typing, Polymerase Chain Reaction, Retrospective Studies, Sepsis/epidemiology/microbiology, Survival Analysis, Vancomycin-Resistant Enterococci/classification/genetics/isolation & purification, Young Adult	Phylogeny
Phylogeny	28228089	Genotypic Characterization of Vancomycin-Resistant Enterococcus spp. In Tertiary Center, Iran.	Shokouhi S, Darazam IA, Javadi A, Rouhani M, Ghasemnejad M	Infect Disord Drug Targets	10.2174/1871526517666170210164649	2017	Adult, Anti-Bacterial Agents/pharmacology, Enterococcus/classification/drug effects/genetics/isolation & purification, Enterococcus faecalis/genetics/isolation & purification, Enterococcus faecium/genetics/isolation & purification, Feces/microbiology, Female, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Iran/epidemiology, Male, Microbial Sensitivity Tests, Middle Aged, Phenotype, Vancomycin/pharmacology, Vancomycin Resistance/*genetics	Enzymology
Enzymology	28698020	First outbreak of colonization by linezolid- and glycopeptide-resistant Enterococcus faecium harbouring the cfr gene in a UK nephrology unit.	Inkster T, Coia J, Meunier D, Doumith M, Martin K, Pike R, Imrie L, Kane H, Hay M, Wiuff C, Wilson J, Deighan C, Hopkins KL, Woodford N, Hill R	J Hosp Infect	10.1016/j.jhin.2017.07.003	2017	Anti-Bacterial Agents/pharmacology, Carrier State/epidemiology/microbiology, Cross Infection/epidemiology/microbiology, Drug Resistance, Bacterial, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/classification/drug effects/genetics/isolation & purification, Genes, Bacterial, Genotype, Glycopeptides/pharmacology, Gram-Positive Bacterial Infections/epidemiology/microbiology, Hospital Departments, Humans, Infection Control/methods, Linezolid/*pharmacology, Male, Middle Aged, Polymerase Chain Reaction, Sequence Analysis, DNA, United Kingdom	Pathogenicity
Pathogenicity	28735051	Telavancin activity in vitro tested against a worldwide collection of Gram-positive clinical isolates (2014).	Duncan LR, Sader HS, Smart JI, Flamm RK, Mendes RE	J Glob Antimicrob Resist	10.1016/j.jgar.2017.03.018	2017	Americas/epidemiology, Aminoglycosides/pharmacology, Anti-Bacterial Agents/pharmacology, Asia/epidemiology, Community-Acquired Infections/microbiology, Cross Infection/microbiology, Europe/epidemiology, Gram-Positive Bacteria/classification/drug effects/isolation & purification, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Lipoglycopeptides/*pharmacology, Microbial Sensitivity Tests, Population Surveillance	Phylogeny
Enzymology	28754459	First description in Europe of the emergence of Enterococcus faecium ST117 carrying both vanA and vanB genes, isolated in Greece.	Papagiannitsis CC, Malli E, Florou Z, Medvecky M, Sarrou S, Hrabak J, Petinaki E	J Glob Antimicrob Resist	10.1016/j.jgar.2017.07.010	2017	Anti-Bacterial Agents/pharmacology, Bacteremia/microbiology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Electrophoresis, Gel, Pulsed-Field, Enterococcus faecium/drug effects/genetics/isolation & purification/pathogenicity, Europe, Gene Expression Regulation, Bacterial, Genes, Bacterial/genetics, Genotype, Gram-Positive Bacterial Infections/microbiology, Greece/epidemiology, Hospitals, Humans, Microbial Sensitivity Tests, *Molecular Epidemiology, Multilocus Sequence Typing, Phenotype, Plasmids/genetics, Protein Kinases/genetics, Teicoplanin/pharmacology, Transcription Factors/genetics, Vancomycin/pharmacology, Vancomycin Resistance, Vancomycin-Resistant Enterococci/genetics	Pathogenicity
Enzymology	28784674	Comparative Pharmacodynamics of Single-Dose Oritavancin and Daily High-Dose Daptomycin Regimens against Vancomycin-Resistant Enterococcus faecium Isolates in an In Vitro Pharmacokinetic/Pharmacodynamic Model of Infection.	Belley A, Lalonde-Seguin D, Arhin FF, Moeck G	Antimicrob Agents Chemother	10.1128/AAC.01265-17	2017	Anti-Bacterial Agents/pharmacokinetics/pharmacology, Daptomycin/pharmacokinetics/pharmacology, Enterococcus faecium/drug effects/isolation & purification, Glycopeptides/pharmacokinetics/pharmacology, Gram-Positive Bacterial Infections/drug therapy, Humans, Lipoglycopeptides, Microbial Sensitivity Tests, Vancomycin Resistance/physiology, Vancomycin-Resistant Enterococci/drug effects/isolation & purification	Pathogenicity
Phylogeny	29110155	Streptomyces swartbergensis sp. nov., a novel tyrosinase and antibiotic producing actinobacterium.	le Roes-Hill M, Prins A, Meyers PR	Antonie Van Leeuwenhoek	10.1007/s10482-017-0979-3	2017	Anti-Bacterial Agents/biosynthesis/isolation & purification/pharmacology, Bacteria/drug effects, DNA Gyrase/genetics, Diaminopimelic Acid/analysis, Fatty Acids/analysis, Glycolipids/analysis, Melanins/analysis, Monophenol Monooxygenase/biosynthesis, Peptidoglycan/analysis, Phospholipids/analysis, Phylogeny, RNA, Ribosomal, 16S/genetics, Soil Microbiology, South Africa, Streptomyces/chemistry/classification/enzymology/genetics, Vitamin K 2/analysis	Enzymology
Enzymology	29175606	High rates of colonisation by ampicillin-resistant enterococci in residents of long-term care facilities in Porto, Portugal.	Freitas AR, Novais C, Duarte B, Pereira AP, Coque TM, Peixe L	Int J Antimicrob Agents	10.1016/j.ijantimicag.2017.11.007	2017	Aged, Aged, 80 and over, Ampicillin/pharmacology, Anti-Bacterial Agents/pharmacology, Carrier State/epidemiology/microbiology, Cross Infection/epidemiology/microbiology, Electrophoresis, Gel, Pulsed-Field, Enterococcus/classification/drug effects/genetics/isolation & purification, Feces/microbiology, Female, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology, Health Facilities, Humans, Long-Term Care, Male, Molecular Epidemiology, Multilocus Sequence Typing, Plasmids/analysis, Polymerase Chain Reaction, Portugal/epidemiology, *beta-Lactam Resistance	Pathogenicity
Genetics	29245276	Clinical and microbiological characteristics of vancomycin-resistant Enterococcus faecium bloodstream infection in Central Taiwan.	Chen CH, Lin LC, Chang YJ, Chang CY	Medicine (Baltimore)	10.1097/MD.0000000000009000	2017	Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/therapeutic use, Bacteremia/drug therapy/epidemiology/microbiology, Bacteriological Techniques, Enterococcus faecium, Female, Genotype, Gram-Positive Bacterial Infections/drug therapy/epidemiology/physiopathology, Humans, Male, Middle Aged, Risk Factors, Taiwan/epidemiology, Vancomycin Resistance, Young Adult	Pathogenicity
Pathogenicity	29308974	Immunological responses against vancomycin-resistant Enterococcus faecium and Enterococcus faecalis by mice.	Cho YS, Lee MH, Kim JM, Lee HS, Yoo HS, Park YH, Ryu PD	J Immunoassay Immunochem	10.1080/15321819.2017.1407943	2018	Animals, Anti-Bacterial Agents/administration & dosage/pharmacology, Drug Resistance, Bacterial/drug effects, Enterococcus faecalis/drug effects, Enterococcus faecium/drug effects, Mice, Mice, Inbred ICR, Microbial Sensitivity Tests, Vancomycin/administration & dosage/*pharmacology
	29348921	Genetic characteristics of VanA-type vancomycin-resistant Enterococcus faecalis and Enterococcus faecium in Cuba.	Quinones D, Aung MS, Sousa Martins JP, Urushibara N, Kobayashi N	New Microbes New Infect	10.1016/j.nmni.2017.12.001	2017
Pathogenicity	29407752	Presence of the esp gene in Enterococcus faecium derived from oropharyngeal microbiota of haematology patients.	Jovanovic M, Tosic T, Jovanovic S, Stosovic R, Stevanovic G, Velebit B, Zervos MJ	Arch Oral Biol	10.1016/j.archoralbio.2018.01.008	2018	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, DNA, Bacterial, Enterococcus/drug effects/genetics/isolation & purification, Enterococcus faecium/drug effects/genetics/isolation & purification, Feces/microbiology, Genes, Bacterial, Genotype, Hematology, Humans, Membrane Proteins/genetics, Microbiota/drug effects/genetics, Multiplex Polymerase Chain Reaction, Oropharynx/microbiology, Vancomycin-Resistant Enterococci/drug effects/genetics, Virulence Factors/genetics	Enzymology
Pathogenicity	29664245	Analysis of the world epidemiological situation among vancomycin-resistant Enterococcus faecium infections and the current situation in Poland	Talaga-Cwiertnia K, Bulanda M	Przegl Epidemiol		2018	Enterococcus faecium, Gram-Positive Bacterial Infections/epidemiology, Humans, Poland/epidemiology, *Vancomycin-Resistant Enterococci
Pathogenicity	29750597	Dissemination of VanA-Type Enterococcus faecium Isolates in Hungary.	Melegh S, Nyul A, Kovacs K, Kovacs T, Ghidan A, Dombradi Z, Szabo J, Berta B, Lesinszki V, Paszti J, Toth A, Mestyan G	Microb Drug Resist	10.1089/mdr.2017.0296	2018	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, DNA, Bacterial/genetics, Enterococcus faecium/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/drug therapy/microbiology, Humans, Hungary, Multilocus Sequence Typing/methods, Plasmids/genetics, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	29885179	Vancomycin resistant Enterococci: A brief review.	Raza T, Ullah SR, Mehmood K, Andleeb S	J Pak Med Assoc	8691	2018	Anti-Bacterial Agents/pharmacology/therapeutic use, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Enterococcus faecalis/drug effects/genetics/pathogenicity, Enterococcus faecium/drug effects/genetics/pathogenicity, Gram-Positive Bacterial Infections/drug therapy, Humans, Vancomycin/pharmacology/therapeutic use, Vancomycin Resistance/genetics, Vancomycin-Resistant Enterococci/*drug effects/genetics/pathogenicity
Phylogeny	29957103	Characterization of Clinical Vancomycin-Resistant Enterococcus faecium Isolated in Eastern Hungary.	Franyo D, Kocsi B, Lesinszki V, Paszti J, Kozak A, Bukta EE, Szabo J, Dombradi Z	Microb Drug Resist	10.1089/mdr.2018.0074	2018
Genetics	30012442	Emergence of unusual vanA/vanB2 genotype in a highly mutated vanB2-vancomycin-resistant hospital-associated E. faecium background in Vietnam.	Santona A, Taviani E, Hoang HM, Fiamma M, Deligios M, Ngo TVQ, Van Le A, Cappuccinelli P, Rubino S, Paglietti B	Int J Antimicrob Agents	10.1016/j.ijantimicag.2018.07.006	2018	Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Chromosomes, Bacterial, Cross Infection/epidemiology/microbiology/transmission, DNA Transposable Elements, Disease Transmission, Infectious, Drug Resistance, Bacterial, Enterococcus faecium/genetics/isolation & purification, Evolution, Molecular, Gene Transfer, Horizontal, Genotype, Gram-Positive Bacterial Infections/epidemiology/microbiology/transmission, Hospitals, Humans, Molecular Epidemiology, Molecular Typing, Mutation, Operon, Plasmids, Polymorphism, Single Nucleotide, Teicoplanin/pharmacology, Vancomycin/pharmacology, Vancomycin-Resistant Enterococci/classification/genetics/*isolation & purification, Vietnam/epidemiology, Whole Genome Sequencing	Phylogeny
Genetics	30533817	Draft Genome Sequence of Enterococcus faecium CL-6729, a Clinical Isolate Showing Constitutive Vancomycin Resistance.	Monteiro da Silva BN, Faria AR, de Souza SDSR, Planet PJ, Merquior VLC, Teixeira LM	Microbiol Resour Announc	10.1128/MRA.00888-18	2018
Pathogenicity	30597255	Phenotypic and genetic characteristics of vancomycin-resistant Enterococcus faecium.	Yang J, Yuan Y, Tang M, Liu L, Yang K, Liu J	Microb Pathog	10.1016/j.micpath.2018.12.046	2018	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Carrier Proteins/genetics, China, Drug Resistance, Multiple, Bacterial/drug effects/genetics, Enterococcus faecium/drug effects/enzymology/genetics, Gene Amplification, Genes, Bacterial/genetics, Genetic Variation, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Membrane Proteins/genetics, Microbial Sensitivity Tests, Molecular Typing, Multilocus Sequence Typing, Phenotype, Vancomycin-Resistant Enterococci/drug effects/genetics, Virulence Factors/genetics, Whole Genome Sequencing	Genetics
	30619158	Impact on Public Health of the Spread of High-Level Resistance to Gentamicin and Vancomycin in Enterococci.	Sparo M, Delpech G, Garcia Allende N	Front Microbiol	10.3389/fmicb.2018.03073	2018
Pathogenicity	30753495	In vitro activity of oritavancin alone or in combination against vancomycin-susceptible and -resistant enterococci.	Wu T, Meyer K, Harrington AT, Danziger LH, Wenzler E	J Antimicrob Chemother	10.1093/jac/dkz010	2019	Anti-Bacterial Agents/pharmacology, Bacteremia/microbiology, Drug Resistance, Multiple, Bacterial, Drug Synergism, Drug Therapy, Combination, Enterococcus/drug effects, Gram-Positive Bacterial Infections/blood, Humans, Lipoglycopeptides/pharmacology, Microbial Sensitivity Tests, Vancomycin/pharmacology, Vancomycin-Resistant Enterococci/drug effects
Pathogenicity	31151413	Species, antibiotic susceptibility profiles and van gene frequencies among enterococci isolated from patients at Mulago National Referral Hospital in Kampala, Uganda.	Kateete DP, Edolu M, Kigozi E, Kisukye J, Baluku H, Mwiine FN, Najjuka CF	BMC Infect Dis	10.1186/s12879-019-4136-7	2019	Adult, Carrier State/epidemiology/microbiology, Cross-Sectional Studies, Female, Gene Frequency, Gram-Positive Bacterial Infections/epidemiology/microbiology, Humans, Male, Microbial Sensitivity Tests, Polymerase Chain Reaction, Referral and Consultation, Secondary Care Centers/statistics & numerical data, Uganda/epidemiology, Vancomycin/therapeutic use, Vancomycin Resistance/drug effects/genetics, Vancomycin-Resistant Enterococci/classification/drug effects/genetics/isolation & purification, Young Adult	Phylogeny
Pathogenicity	31232334	VanA-type vancomycin-resistant Enterococcus faecium ST1336 isolated from mussels in an anthropogenically impacted ecosystem.	Sacramento AG, Fernandes MR, Sellera FP, Dolabella SS, Zanella RC, Cerdeira L, Lincopan N	Mar Pollut Bull	10.1016/j.marpolbul.2019.04.014	2019	Animals, Bacterial Proteins/genetics, Brazil, Carbon-Oxygen Ligases/genetics, DNA Transposable Elements, Ecosystem, Enterococcus faecium/drug effects/genetics/isolation & purification, Humans, Microbial Sensitivity Tests, Perna/microbiology, Vancomycin Resistance/genetics	Enzymology
Pathogenicity	31339695	TiCaPCON-Supported Pt- and Fe-Based Nanoparticles and Related Antibacterial Activity.	Ponomarev VA, Sheveyko AN, Permyakova ES, Lee J, Voevodin AA, Berman D, Manakhov AM, Michlicek M, Slukin PV, Firstova VV, Ignatov SG, Chepkasov IV, Popov ZI, Shtansky DV	ACS Appl Mater Interfaces	10.1021/acsami.9b09649	2019	Anti-Bacterial Agents/chemistry/pharmacology, Bacteria/growth & development, Humans, Iron/chemistry/pharmacology, Lymphocytes/metabolism, Materials Testing, Metal Nanoparticles/chemistry, *Platinum/chemistry/pharmacology	Metabolism
Genetics	31686360	Assessing the intestinal carriage rates of vancomycin-resistant enterococci (VRE) at a tertiary care hospital in Hungary.	Franyo D, Kocsi B, Bukta EE, Szabo J, Dombradi Z	Folia Microbiol (Praha)	10.1007/s12223-019-00751-x	2019	Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents/pharmacology/therapeutic use, Carrier State/epidemiology/microbiology, Child, Child, Preschool, Feces/microbiology, Female, Genotype, Gram-Positive Bacterial Infections/drug therapy/epidemiology/microbiology, Humans, Hungary/epidemiology, Intestines/microbiology, Male, Microbial Sensitivity Tests, Middle Aged, Retrospective Studies, Risk Factors, Tertiary Care Centers, Vancomycin Resistance/genetics, Vancomycin-Resistant Enterococci/*isolation & purification, Young Adult	Pathogenicity
Pathogenicity	31798546	Novel Multidrug-Resistant Enterococcal Mobile Linear Plasmid pELF1 Encoding vanA and vanM Gene Clusters From a Japanese Vancomycin-Resistant Enterococci Isolate.	Hashimoto Y, Taniguchi M, Uesaka K, Nomura T, Hirakawa H, Tanimoto K, Tamai K, Ruan G, Zheng B, Tomita H	Front Microbiol	10.3389/fmicb.2019.02568	2019
Pathogenicity	31931148	Expression of VanA-type vancomycin resistance in a clinical isolate of Enterococcus faecium showing insertion of IS19 in the vanS gene.	Monteiro da Silva BN, Faria AR, Souza SDSR, Colodette SS, Morais JM, Teixeira LM, Merquior VLC	Int J Antimicrob Agents	10.1016/j.ijantimicag.2020.105897	2020	Bacterial Proteins/genetics, DNA Transposable Elements/genetics, Drug Resistance, Multiple, Bacterial/genetics, Enterococcus faecium/drug effects/genetics/isolation & purification, Gram-Positive Bacterial Infections/drug therapy, Humans, Microbial Sensitivity Tests, Mutagenesis, Insertional/genetics, Protein Kinases/genetics, Transcription Factors/genetics, Urinary Tract Infections/drug therapy/microbiology, Vancomycin/pharmacology, Vancomycin Resistance/*genetics	Enzymology
Pathogenicity	32021333	Antibiotic Resistance and Molecular Epidemiology of Vancomycin-Resistant Enterococci in a Tertiary Care Hospital in Turkey.	Asgin N, Otlu B	Infect Drug Resist	10.2147/IDR.S191881	2020
Pathogenicity	32242789	Antibiogram of Urinary Enterococcus Isolates from a Tertiary Care Hospital.	Bhat NR, Shivashankar SBK, Dhanashree B	Infect Disord Drug Targets	10.2174/1871526520666200403140618	2021	Anti-Bacterial Agents/pharmacology, Gram-Positive Bacterial Infections, Humans, Microbial Sensitivity Tests, Tertiary Care Centers, Vancomycin, Vancomycin Resistance, Vancomycin-Resistant Enterococci/*drug effects
Genetics	32269153	First Report of the Local Spread of Vancomycin-Resistant Enterococci Ascribed to the Interspecies Transmission of a vanA Gene Cluster-Carrying Linear Plasmid.	Hashimoto Y, Kita I, Suzuki M, Hirakawa H, Ohtaki H, Tomita H	mSphere	10.1128/mSphere.00102-20	2020	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Drug Resistance, Multiple, Bacterial/genetics, Electrophoresis, Gel, Pulsed-Field, Enterococcus/genetics, Enterococcus faecium/genetics, Gene Transfer, Horizontal, Genome, Bacterial, Gram-Positive Bacterial Infections/microbiology, Humans, Microbial Sensitivity Tests, Multigene Family, Plasmids/genetics, Vancomycin Resistance/genetics, Vancomycin-Resistant Enterococci/classification/genetics/pathogenicity, Whole Genome Sequencing	Enzymology
Pathogenicity	32315459	Quantifying Human Health Risks from Virginiamycin Use in Food Animals in China.	Cox LA Jr, Popken DA, Sun J, Liao XP, Fang LX	Risk Anal	10.1111/risa.13466	2020	Animals, Anti-Bacterial Agents/administration & dosage/pharmacology/toxicity, Chickens, China, Humans, Meat Products/microbiology, Microbial Sensitivity Tests, Vancomycin-Resistant Enterococci/drug effects, Virginiamycin/administration & dosage/*toxicity
	32318043	VanZ Reduces the Binding of Lipoglycopeptide Antibiotics to Staphylococcus aureus and Streptococcus pneumoniae Cells.	Vimberg V, Zieglerova L, Buriankova K, Branny P, Balikova Novotna G	Front Microbiol	10.3389/fmicb.2020.00566	2020
Phenotype	32340989	Impact of vanA-Positive Enterococcus faecium Exhibiting Diverse Susceptibility Phenotypes to Glycopeptides on 30-Day Mortality of Patients with a Bloodstream Infection.	Kim D, Yoon EJ, Hong JS, Lee H, Shin KS, Shin JH, Kim YR, Kim HS, Kim YA, Uh Y, Shin JH, Park YS, Jeong SH	Antimicrob Agents Chemother	10.1128/AAC.02180-19	2020	Anti-Bacterial Agents/pharmacology/therapeutic use, Bacteremia/drug therapy, Bacterial Proteins/genetics, Enterococcus faecium/genetics, Glycopeptides, *Gram-Positive Bacterial Infections/drug therapy, Humans, Phenotype, Prospective Studies, Republic of Korea, Vancomycin Resistance/genetics	Pathogenicity
Pathogenicity	32409678	N-Terminal guanidine derivatives of teicoplanin antibiotics strongly active against glycopeptide resistant Enterococcus faecium.	Szucs Z, Bereczki I, Roth E, Milankovits M, Ostorhazi E, Batta G, Nagy L, Dombradi Z, Borbas A, Herczegh P	J Antibiot (Tokyo)	10.1038/s41429-020-0313-6	2020	Anti-Bacterial Agents/pharmacology, Drug Resistance, Microbial/drug effects, Enterococcus faecium/drug effects, Glycopeptides/pharmacology, Gram-Positive Bacteria/drug effects, Gram-Positive Bacterial Infections/drug therapy, Guanidines/pharmacology, Humans, Microbial Sensitivity Tests/methods, Teicoplanin/pharmacology
	33171728	Analysis of Vancomycin-Resistant Enterococci in Hemato-Oncological Patients.	Hricova K, Stosova T, Kucova P, Fiserova K, Bardon J, Kolar M	Antibiotics (Basel)	10.3390/antibiotics9110785	2020
Metabolism	33831063	ddcP, pstB, and excess D-lactate impact synergism between vancomycin and chlorhexidine against Enterococcus faecium 1,231,410.	Bhardwaj P, Islam MZ, Kim C, Nguyen UT, Palmer KL	PLoS One	10.1371/journal.pone.0249631	2021	ATP-Binding Cassette Transporters/genetics/metabolism, Adenosine Triphosphatases/genetics/metabolism, Anti-Bacterial Agents/pharmacology, Anti-Infective Agents, Local/pharmacology, Bacterial Proteins/genetics/metabolism, Chlorhexidine/pharmacology, Drug Synergism, Enterococcus faecium/drug effects, Gram-Positive Bacterial Infections/drug therapy/genetics/microbiology, Humans, Lactic Acid/metabolism, Vancomycin/*pharmacology	Pathogenicity
Metabolism	34060906	Effect of Vancomycin on Cytoplasmic Peptidoglycan Intermediates and van Operon mRNA Levels in VanA-Type Vancomycin-Resistant Enterococcus faecium.	Gargvanshi S, Vemula H, Gutheil WG	J Bacteriol	10.1128/JB.00230-21	2021	Anti-Bacterial Agents/pharmacology, Bacterial Proteins/genetics/metabolism, Carbon-Oxygen Ligases/genetics/metabolism, Cell Wall/drug effects/genetics/metabolism, Enterococcus faecium/drug effects/enzymology/genetics/metabolism, Operon/drug effects, Peptidoglycan/metabolism, RNA, Messenger/genetics/metabolism, Vancomycin/*pharmacology, Vancomycin Resistance	Pathogenicity
Biotechnology	34163185	Characterisation of ESKAPE Pathogens with Special Reference to Multidrug Resistance and Biofilm Production in a Nepalese Hospital.	Pandey R, Mishra SK, Shrestha A	Infect Drug Resist	10.2147/IDR.S306688	2021		Pathogenicity
Phylogeny	34285270	Transmission dynamics of a linear vanA-plasmid during a nosocomial multiclonal outbreak of vancomycin-resistant enterococci in a non-endemic area, Japan.	Fujiya Y, Harada T, Sugawara Y, Akeda Y, Yasuda M, Masumi A, Hayashi J, Tanimura N, Tsujimoto Y, Shibata W, Yamaguchi T, Kawahara R, Nishi I, Hamada S, Tomono K, Kakeya H	Sci Rep	10.1038/s41598-021-94213-5	2021	Aged, Antimicrobial Stewardship, Bacterial Proteins/genetics, Carbon-Oxygen Ligases/genetics, Case-Control Studies, Cross Infection/microbiology/transmission, Disease Outbreaks, Electrophoresis, Gel, Pulsed-Field, Endemic Diseases, Female, Gram-Positive Bacterial Infections/transmission, Humans, Japan, Male, Phylogeny, Plasmids/genetics, Population Surveillance, Vancomycin-Resistant Enterococci/*classification/genetics/isolation & purification	Enzymology
Pathogenicity	34285472	In vitro Antimicrobial Activity of Fosfomycin, Rifampin, Vancomycin, Daptomycin Alone and in Combination Against Vancomycin-Resistant Enterococci.	Tong J, Jiang Y, Xu H, Jin X, Zhang L, Ying S, Yu W, Qiu Y	Drug Des Devel Ther	10.2147/DDDT.S315061	2021	Anti-Bacterial Agents/administration & dosage/pharmacology, Biofilms/drug effects, Drug Therapy, Combination, Enterococcus faecalis/drug effects/genetics, Enterococcus faecium/drug effects/genetics, Genes, Bacterial, Humans, Microbial Sensitivity Tests, Multilocus Sequence Typing, Vancomycin/administration & dosage/pharmacology, Vancomycin Resistance/genetics, Vancomycin-Resistant Enterococci/drug effects/genetics
Genetics	34718966	Genetic description of VanD phenotype vanA genotype in vancomycin-resistant Enterococcus faecium isolates from a Bone Marrow Transplantation Unit.	Marchi AP, Neto LVP, Cortes MF, de Castro Lima VAC, Martins RCR, Franco LAM, Rossi F, Rocha V, Levin AS, Costa SF	Braz J Microbiol	10.1007/s42770-021-00634-9	2021	Anti-Bacterial Agents/pharmacology/therapeutic use, Bacterial Proteins/genetics, Bone Marrow Transplantation, Carbon-Oxygen Ligases/genetics, Enterococcus faecium/genetics, Genotype, Gram-Positive Bacterial Infections/microbiology, Humans, Phenotype, Vancomycin/pharmacology, Vancomycin Resistance	Phenotype
	34733028	Increasing Trend of Vancomycin-resistant Enterococci Bacteremia in a Tertiary Care Hospital of South India: A Three-year Prospective Study.	Sivaradjy M, Gunalan A, Priyadarshi K, Madigubba H, Rajshekar D, Sastry AS	Indian J Crit Care Med	10.5005/jp-journals-10071-23916	2021
Pathogenicity	34918959	Detection of Vancomycin-Resistant Enterococcus faecium Endocarditis After Clearance of Vancomycin-Sensitive Enterococcus faecium Bacteremia.	McEllistrem MC, Nordstrom HR, Lucas A, Decker BK, Van Tyne D	Microb Drug Resist	10.1089/mdr.2021.0233	2021	Aged, Anti-Bacterial Agents/pharmacology, Bacteremia/drug therapy/microbiology, Daptomycin/therapeutic use, Drug Resistance, Multiple, Bacterial, Endocarditis, Bacterial/drug therapy/microbiology, Enterococcus faecium, Genes, Bacterial, Humans, Male, Microbial Sensitivity Tests, Pacemaker, Artificial/microbiology, Tricuspid Valve/microbiology, Vancomycin-Resistant Enterococci/drug effects/*isolation & purification	Enzymology
Pathogenicity	34958996	Glycopeptide resistance in Enterococcus spp. and coagulase-negative staphylococci from hospitalised patients in Germany: occurrence, characteristics and dalbavancin susceptibility.	Kresken M, Klare I, Wichelhaus TA, Wohlfarth E, Layer-Nicolaou F, Neumann B, Werner G	J Glob Antimicrob Resist	10.1016/j.jgar.2021.12.016	2021	Anti-Bacterial Agents/pharmacology/therapeutic use, Coagulase, Enterococcus, Glycopeptides/pharmacology, Humans, Microbial Sensitivity Tests, Staphylococcus, Teicoplanin/analogs & derivatives/pharmacology, Vancomycin/pharmacology
	35204419	Rapid and Reproducible MALDI-TOF-Based Method for the Detection of Vancomycin-Resistant Enterococcus faecium Using Classifying Algorithms.	Candela A, Arroyo MJ, Sanchez-Molleda A, Mendez G, Quiroga L, Ruiz A, Cercenado E, Marin M, Munoz P, Mancera L, Rodriguez-Temporal D, Rodriguez-Sanchez B	Diagnostics (Basel)	10.3390/diagnostics12020328	2022
	35336207	High-Resolution Genotyping Unveils Identical Ampicillin-Resistant Enterococcus faecium Strains in Different Sources and Countries: A One Health Approach.	Freitas AR, Tedim AP, Almeida-Santos AC, Duarte B, Elghaieb H, Abbassi MS, Hassen A, Novais C, Peixe L	Microorganisms	10.3390/microorganisms10030632	2022
	35395119	Nigella sativa oil extract: A natural novel specific conjugal transfer inhibitor of vancomycin resistance from vanA/B-resistant Enterococcus faecium to Staphylococcus aureus.	Ahmad AAM, Gharib AA, Elshorbgy I, Elewasy OA, Elmowalid GA	J Appl Microbiol	10.1111/jam.15567	2022
Pathogenicity	35969069	Library Screening for Synergistic Combinations of FDA-Approved Drugs and Metabolites with Vancomycin against VanA-Type Vancomycin-Resistant Enterococcus faecium.	Gargvanshi S, Gutheil WG	Microbiol Spectr	10.1128/spectrum.01412-22	2022	Humans, Vancomycin/pharmacology, Enterococcus faecium, Linezolid, Methicillin-Resistant Staphylococcus aureus, Mupirocin, Gram-Positive Bacterial Infections/drug therapy, Vancomycin-Resistant Enterococci, Microbial Sensitivity Tests, Anti-Bacterial Agents/pharmacology/therapeutic use, Rifabutin, *Rifamycins

Reference

@id	authors	catalogue	doi/url	title
6710	Curators of the DSMZ	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH (DSM 17050)	https://www.dsmz.de/collection/catalogue/details/culture/DSM-17050
20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.		10.1099/ijsem.0.004332	List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ
68381				Automatically annotated from API rID32STR
74790	Reimer, L.C., Lissin, A.,Schober, I., Witte,J.F., Podstawka, A., Lüken, H., Bunk, B.,Overmann, J.		10.60712/SI-ID297649.1	StrainInfo: A central database for resolving microbial strain identifiers

General

NCBI tax id

strain history

Name and taxonomic classification

LPSN

synonyms

Morphology

colony morphology

Culture and growth conditions

culture medium

culture temp

Physiology and metabolism

oxygen tolerance

antibiogram

observation

metabolite utilization

metabolite production

metabolite tests

enzymes

API rID32STR

Isolation, sampling and environmental information

isolation

isolation source categories

Safety information

risk assessment

External links

straininfo link

literature

Reference