Mycoplasmoides pneumoniae (DSM 23978, ATCC 15531, Eaton Agent)

Name: Mycoplasmoides pneumoniae (DSM 23978, ATCC 15531, Eaton Agent)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 8615

Type strain

Strain Designation FH

Culture col. no. DSM 23978 ATCC 15531 Eaton Agent NCTC 10119 CIP 103766 2 more

NCBI tax ID(s) 2104

Special Collections DSMZ CIP

History DSMZ <- R. Herrmann, ZMBH; FH <- ATCC; ATCC 15531 <- L. Hayflick; <- C. Liu; Eaton Agent

Links

Mycoplasmoides pneumoniae FH is an aerobe bacterium that was isolated from monkey kidney tissue-culture fluids of the FH strain supplied by C. Liu, who recovered this strain in embryonated eggs from a student with atypical pneumonia..

aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 311028

ATCC 15531,NCTC 10119,CCUG 37457,CIP 103766,CCUG 3589,IFO 14401,NBRC 14401,DSM 23978

@ref 20215

Last LPSN update 2026-05-29 08:26:54

Domain Bacteria

Phylum Mycoplasmatota

Class Mollicutes

Order Mycoplasmoidales

Family Mycoplasmoidaceae

Genus Mycoplasmoides

Species Mycoplasmoides pneumoniae

Full scientific name Mycoplasmoides pneumoniae (Somerson et al. 1963) Gupta et al. 2018

Synonyms (2)

Mycoplasma pneumoniae
"Schizoplasma pneumoniae"

BacDive ID	Other strains from **Mycoplasmoides pneumoniae** (1)	Type strain
8616	M. pneumoniae M129, M129-B7, DSM 23979, ATCC 29342

Morphology

Cell morphology

@ref	Motility	Confidence	Gram stain
125438		95.171
125439		98.55	negative

Colony morphology

17469

Incubation period2-3 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
17469	SP4-Z MEDIUM (DSMZ Medium 1076b)		Medium recipe at MediaDive	Name: SP4-Z MEDIUM (DSMZ Medium 1076b) Composition: Agar 10.0 g/l Tryptone 10.0 g/l Bacto peptone 5.0 g/l PPLO broth 3.5 g/l Urea 2.0 g/l Glucose 1.0 g/l None 1.0 g/l Yeast extract 0.4 g/l DNA 0.2 g/l CMRL 1066 Fetal bovine serum Swine serum Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
17469	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
17469	aerobe
125439	obligate aerobe	93.398

Spore formation

@ref	Spore formation	Confidence
125438		95.861
125439		99.856

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Laboratory	#Lab enrichment
#Host	#Mammals	#Primates
#Host	#Microbial	#Viriome
#Host Body-Site	#Urogenital tract	#Kidney

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
17469	monkey kidney tissue-culture fluids of the FH strain (Eaton Agent Virus) supplied by C. Liu, who recovered this strain in embryonated eggs from a student with atypical pneumonia.	USA	USA	North America

Taxonmaps

69479

Global distribution of 16S sequence AF132740 (>99% sequence identity) for Mycoplasma pneumoniae from Microbeatlas

Aquatic Samples	113
Soil Samples	32
Animal Samples	1165
Plant Samples	5
Total Samples	1315

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
17469	2	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	50648_A01-3 assembly for Mycoplasmoides pneumoniae NCTC10119	complete	GCA_900660465	2104.332	8045958143	2104	96.42

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Mycoplasma pneumoniae gene for 16S rRNA, partial sequence	AB069819	251	2104
20218	Mycoplasma pneumoniae strain ATCC 15531 16S ribosomal RNA gene and 16S-23S rRNA intergenic spacer, complete sequence	AF132740	1740	722438
20218	Mycoplasma pneumoniae strain ATCC 15531 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	AY816339	862	722438

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: 50648_A01-3 assembly for Mycoplasmoides pneumoniae NCTC10119
BV-BRC: 2104.332

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	93.40	no
125439	gram_stain	BacteriaNetⓘ	negative	98.55	no
125439	motility	BacteriaNetⓘ	no	71.71	no
125439	spore_formation	BacteriaNetⓘ	no	99.86	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Mycoplasma pneumoniae NCTC10119
NCBI: GCA_900660465.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	63.52	no
125438	anaerobic	anaerobicⓘ	no	87.58	no
125438	aerobic	aerobicⓘ	no	83.74	yes
125438	spore-forming	spore-formingⓘ	no	95.86	no
125438	thermophilic	thermophileⓘ	no	97.33	no
125438	flagellated	motile2+ⓘ	no	95.17	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Influenza A Virus and Mycoplasma pneumoniae Coinfection Mediates Immune Dysregulation and Exacerbates Disease Severity.	Wu Y, Zhu Q, Liu J, Chuan H, He L, Wang M, Xu L, Zhang R, Liu Y, Liao G, Li W, Sun C, Zhou J.	Int J Mol Sci	10.3390/ijms262110487	2025
Genetics	Increased macrolide resistance rate of Mycoplasma pneumoniae correlated with epidemic in Beijing, China in 2023.	Chen Y, Jia X, Gao Y, Ren X, Du B, Zhao H, Feng Y, Xue G, Cui J, Gan L, Feng J, Fan Z, Fu T, Xu Z, Yu Z, Yang Y, Zhao S, Huang L, Ke Y, Cao L, Yan C, Yuan J.	Front Microbiol	10.3389/fmicb.2024.1449511	2024
Enzymology	Reconstitution of an active arginine deiminase pathway in Mycoplasma pneumoniae M129.	Rechnitzer H, Rottem S, Herrmann R.	Infect Immun	10.1128/iai.00441-13	2013
Phylogeny	Species identification and subtyping of Ureaplasma parvum and Ureaplasma urealyticum using PCR-based assays.	Kong F, Ma Z, James G, Gordon S, Gilbert GL.	J Clin Microbiol	10.1128/jcm.38.3.1175-1179.2000	2000
Enzymology	Activities of oxidative enzymes in mycoplasmas.	Constantopoulos G, McGarrity GJ.	J Bacteriol	10.1128/jb.169.5.2012-2016.1987	1987
	Identification of an N-terminal 27 kDa fragment of Mycoplasma pneumoniae P116 protein as specific immunogen in M. pneumoniae infections.	Tabassum I, Chaudhry R, Chourasia BK, Malhotra P.	BMC Infect Dis	10.1186/1471-2334-10-350	2010
	Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.	Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.	Antimicrob Agents Chemother	10.1128/aac.01181-10	2011
Pathogenicity	The effects of magainin 2-derived and rationally designed antimicrobial peptides on Mycoplasma pneumoniae.	Hayashi K, Misawa T, Goto C, Demizu Y, Hara-Kudo Y, Kikuchi Y.	PLoS One	10.1371/journal.pone.0261893	2022
	Design, synthesis and antibacterial evaluation of pleuromutilin derivatives.	Wu G, Zhu Z, Li J, Luo X, Zhu W, Liao G, Xia J, Zhang W, Pan W, Li T, Wu S	Bioorg Med Chem	10.1016/j.bmc.2022.116676	2022
Pathogenicity	[Adult respiratory distress syndrome. Two post-operative cases (author's transl)].	Freysz M, Decornet AM, Chalopin JM, Bourdois M, Pothier P, Caillard B	Anesth Analg (Paris)		1981

References

#17469	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 23978
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mycoplasmoides pneumoniae (DSM 23978, ATCC 15531, Eaton Agent)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900660465

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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