Mycobacterium nonchromogenicum (DSM 44164, ATCC 19530, ATCC 23067)

Name: Mycobacterium nonchromogenicum (DSM 44164, ATCC 19530, ATCC 23067)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 8444

Type strain

Culture col. no. DSM 44164 ATCC 19530 ATCC 23067 JCM 6364 NCTC 10424 3 more

NCBI tax ID(s) 1782

Special Collections DSMZ CCUG JCM CIP Wink compendium

History <- ATCC <- M. Tsukamura, 317 (Mycobacterium terrae) M. Tsukamura 09003 (=317). CIP <- 2000, JCM <- M.Tsukamura: strain 09003, Mycobacterium terrae

Links

Mycobacterium nonchromogenicum DSM 44164 is an obligate aerobe, rod-shaped human pathogen that was isolated from soil.

rod-shaped obligate aerobe human pathogen genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 44548

CT1969-01682,ATCC 19530,ATCC 23067,NCTC 10424,CCUG 28009,CIP 106811,JCM 6364,DSM 44164,CNCTC 7283

@ref 20215

Last LPSN update 2026-02-09 11:19:42

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Mycobacteriales

Family Mycobacteriaceae

Genus Mycobacterium

Species Mycobacterium nonchromogenicum

Full scientific name Mycobacterium nonchromogenicum Tsukamura 1965 (Approved Lists 1980)

Synonyms (1)

Mycolicibacter nonchromogenicus

Morphology

Cell morphology

@ref	Cell shape	Confidence	Gram stain
121346	rod-shaped
125438		92.5
125438		90.148	positive
125439		98.2	positive

Colony morphology

@ref	Colony color	Incubation period	Medium used
20009	Light ivory (1015)	10-14 days	5006
20009	Light ivory (1015)	10-14 days	MB7H10
20009	Light ivory (1015)	10-14 days	MB7H11

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
11562	PEPTONE MEAT EXTRACT GLYCEROL AGAR (DSMZ Medium 250)	Medium recipe at MediaDive	Name: PEPTONE MEAT EXTRACT GLYCEROL AGAR (DSMZ Medium 250) Composition: Agar 20.0 g/l Proteose peptone no. 3 5.0 g/l Meat extract 3.0 g/l Glycerol Distilled water
11562	MIDDLEBROOK MEDIUM (DSMZ Medium 645)	Medium recipe at MediaDive	Name: MIDDLEBROOK MEDIUM (DSMZ Medium 645) Composition: Bacto Middlebrook 7H10 agar 20.9945 g/l Glycerol Distilled water
20009	MB7H10		Name: Middlebrook 7H10 (MB7H10) Broth Base Composition: amount in percent Middlebrook 7H10 Agar 1.9% Glycerol 0.5% OADC-Enrichment in ml (NL5633) 10ml Comments: Add broth base and glycerol to ddh2O. Adjust volumes. Autoclave. Cool to 42°C. Add OADC-stock. Sterilisation: 20 minutes Temperature:121°C PH before: PH after: Biological details Culture type: suitable for: Mycobacteria OADC stock solution old broth-name: OADC-Stock Composition: Bovine Serum Albumin, fraction V 5 % 1% Oleic Acid in 0.2N NaOH 5ml Glucose 2 % NaCl 0.85 % Comments: Melt 1% Oleic Acid in 65°C water bath. Dissolve all ingredients in 700ml of ddH2O. Adjust volume to 1L. Filter sterilize and store at 4°C. -To make 1% Oleic Acid in 0.2N NaOH: Dissolve 5g oleic acid (ampule) in 500ml 0.2N NaOH (300ml ddH2O + 20ml NaOH + adjust volume to 500ml). Heat solution to 55°C for oleic acid to melt. Store at -20°C in 50ml aliquots. There is no need to sterilize this. Sterilisation: 20 minutes Temperature:121°C PH before: PH after: Biological details Culture type: suitable for: Mycobacteria
20009	MB7H11		Name: Middlebrook 7H11 (MB7H11) Broth Base Composition: Middlebrook 7H11 Agar 2% Glycerol 0.5% OADC-Enrichment 10ml Comments: Add broth base and glycerol to ddH2O. Adjust volumes. Autoclave. Cool to 42°C. Add OADC-Stock. Sterilisation: 20 minutes Temperature:121°C PH before: PH after: Biological details Culture type: suitable for: Mycobacteria OADC stock solution old broth-name: OADC-Stock Composition: Bovine Serum Albumin, fraction V 5 % 1% Oleic Acid in 0.2N NaOH 5ml Glucose 2 % NaCl 0.85 % Comments: Melt 1% Oleic Acid in 65°C water bath. Dissolve all ingredients in 700ml of ddH2O. Adjust volume to 1L. Filter sterilize and store at 4°C. -To make 1% Oleic Acid in 0.2N NaOH: Dissolve 5g oleic acid (ampule) in 500ml 0.2N NaOH (300ml ddH2O + 20ml NaOH + adjust volume to 500ml). Heat solution to 55°C for oleic acid to melt. Store at -20°C in 50ml aliquots. There is no need to sterilize this. Sterilisation: 20 minutes Temperature:121°C PH before: PH after: Biological details Culture type: suitable for: Mycobacteria
20009	5006		Medium: 5006 Name: Composition (g/l) Sucrose 3,0 Dextrin 15,0 Meat extract 1,0 Yeast extract 2,0 Tryptone soy broth (Oxoid) 5,0 NaCl 0,5 K2HPO4 0,5 MgSO4 x 7 H2O 0,5 FeSO4 x 7 H2O 0,01 Agar 20,0 Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7,3 Usage: Maintenance Organisms: All Actinomycetes
36353	MEDIUM 112 - for Janibacter		Distilled water make up to (1000.000 ml);Magnesium sulphate heptahydrate (1.000 g);Agar (20.000 g);Yeast extract (5.000 g);Peptone (10.000 g);Tween 80 (50.000 mg);Glycerol (2.000 g);Malt extract (5.000 g);Beef extract (2.000 g);Casamino acids (5.000 g);Ca
121346	CIP Medium 112	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
11562	positive	growth	37
20009	positive	optimum	37
36353	positive	growth	37
67770	positive	growth	37
121346	positive	growth	22-37
121346	negative	growth	10
121346	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
121346	obligate aerobe
125439	obligate aerobe	99.5

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68379	17634 ChEBI	D-glucose	-	fermentation	from API Coryne
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
68379	16988 ChEBI	D-ribose	-	fermentation	from API Coryne
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
68379	4853 ChEBI	esculin	-	hydrolysis	from API Coryne
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
121346	606565 ChEBI	hippurate	-	hydrolysis
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
68379	17306 ChEBI	maltose	-	fermentation	from API Coryne
68379	17632 ChEBI	nitrate	-	reduction	from API Coryne
121346	17632 ChEBI	nitrate	+	reduction
121346	17632 ChEBI	nitrate	-	respiration
121346	16301 ChEBI	nitrite	-	reduction
68379	17992 ChEBI	sucrose	+	fermentation	from API Coryne
68379	16199 ChEBI	urea	-	hydrolysis	from API Coryne

Metabolite production

@ref	Chebi-ID	Metabolite	Production
121346	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68379	alkaline phosphatase	+	3.1.3.1	from API Coryne
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68379	alpha-glucosidase	+	3.2.1.20	from API Coryne
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	+	3.2.1.23	from API zym
121346	beta-galactosidase	+	3.2.1.23
68379	beta-galactosidase	+	3.2.1.23	from API Coryne
68382	beta-glucosidase	+	3.2.1.21	from API zym
68379	beta-glucosidase	-	3.2.1.21	from API Coryne
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
121346	catalase	+	1.11.1.6
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
121346	gamma-glutamyltransferase	-	2.3.2.2
121346	gelatinase	-
68379	gelatinase	-		from API Coryne
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68379	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API Coryne
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
121346	oxidase	-
68379	pyrazinamidase	+	3.5.1.B15	from API Coryne
68379	pyrrolidonyl arylamidase	-	3.4.19.3	from API Coryne
68382	trypsin	-	3.4.21.4	from API zym
121346	urease	-	3.5.1.5
68379	urease	-	3.5.1.5	from API Coryne
68382	valine arylamidase	+		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
20009	-	+	-	+	-	+	+	-	-	-	-	not determinedn.d.	-	-	-	-	-	-	+	-	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
20009	not determinedn.d.	+	+	+	-	+	+	+	-	-	+	+	-	+	-	+	+	-	-	+
121346	-	+	+	+	+	+	+	-	-	-	+	+	-	+	-	+	+	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Soil

Isolation

@ref	Sample type
11562	soil
49063	Soil
67770	Soil
121346	Environment, Soil

Taxonmaps

69479

Global distribution of 16S sequence X52928 (>99% sequence identity) for Mycolicibacter from Microbeatlas

Aquatic Samples	1264
Soil Samples	1370
Animal Samples	528
Plant Samples	177
Total Samples	3339

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
11562	2	Risk group (German classification) According to TRBA 466
20009	1	German classification According to TRBA 466
121346	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM210177v1 assembly for Mycolicibacter nonchromogenicus DSM 44164	contig	GCA_002101775	1782.7	8066167219	1782	59.14
66792	ASM2582126v1 assembly for Mycolicibacter nonchromogenicus DSM 44164	scaffold	GCA_025821265	1782.20		1782

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Mycobacterium nonchromogenicum strain ATCC 19530 16S ribosomal RNA gene, partial sequence	DQ058406	1374	1782
20218	Mycobacterium nonchromogenicum strain ATCC 19530 16S ribosomal RNA gene, partial sequence	JN571171	479	1782
20218	M.nonchromogenicum 16S ribosomal RNA	M29565	1376	1782
20218	M.nonchromogenicum 16S ribosomal RNA gene	M59270	146	1782
20218	Mycobacterium nonchromogenicum 16S rRNA gene	X52928	1466	1782
20218	Mycobacterium nonchromogenicum CCUG:28009 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA intergenic spacer, complete sequence; and 23S ribosomal RNA gene, partial sequence	HM584724	278	1782
20218	Mycobacterium nonchromogenicum strain DSM 44164 16S ribosomal RNA gene, partial sequence	AF547952	556	1782
124043	Mycobacterium nonchromogenicum strain DSM 44164 16S-23S ribosomal RNA intergenic spacer, partial sequence.	KT168287	435	1782

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Mycolicibacter nonchromogenicus DSM 44164
NCBI: GCA_025821265

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	80.50	no
125439	motility	BacteriaNetⓘ	no	86.00	no
125439	gram_stain	BacteriaNetⓘ	positive	98.20	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Mycobacterium nonchromogenicum strain DSM 44164
PATRIC: 1782.7

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	90.15	no
125438	anaerobic	anaerobicⓘ	no	94.60	yes
125438	spore-forming	spore-formingⓘ	no	69.57	no
125438	aerobic	aerobicⓘ	yes	83.80	yes
125438	thermophilic	thermophileⓘ	no	94.90	yes
125438	flagellated	motile2+ⓘ	no	92.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	A novel real-time PCR assay for specific detection and quantification of Mycobacterium avium subsp. paratuberculosis in milk with the inherent possibility of differentiation between viable and dead cells.	Dzieciol M, Volgger P, Khol J, Baumgartner W, Wagner M, Hein I.	BMC Res Notes	10.1186/1756-0500-3-251	2010
Phylogeny	Phylogenomics and Comparative Genomic Studies Robustly Support Division of the Genus Mycobacterium into an Emended Genus Mycobacterium and Four Novel Genera.	Gupta RS, Lo B, Son J.	Front Microbiol	10.3389/fmicb.2018.00067	2018
Enzymology	Evaluation of the invader assay with the BACTEC MGIT 960 system for prompt isolation and identification of mycobacterial species from clinical specimens.	Ichimura S, Nagano M, Ito N, Shimojima M, Egashira T, Miyamoto C, Ohkusu K, Ezaki T.	J Clin Microbiol	10.1128/jcm.02289-06	2007
	A Novel Inhibitor against the Biofilms of Non-Tuberculous Mycobacteria.	Kaur P, Krishnamurthy RV, Shandil RK, Mohan R, Narayanan S.	Pathogens	10.3390/pathogens13010040	2023
	Nosiheptide Harbors Potent In Vitro and Intracellular Inhbitory Activities against Mycobacterium tuberculosis.	Yu X, Zhu R, Geng Z, Kong Y, Wang F, Dong L, Zhao L, Xue Y, Ma X, Huang H.	Microbiol Spectr	10.1128/spectrum.01444-22	2022
	In Vitro Activity of the Sudapyridine (WX-081) against Non-Tuberculous Mycobacteria Isolated in Beijing, China.	Zhu R, Shang Y, Chen S, Xiao H, Ren R, Wang F, Xue Y, Li L, Li Y, Chu N, Huang H.	Microbiol Spectr	10.1128/spectrum.01372-22	2022
	In vitro Antimicrobial Activity Comparison of Linezolid, Tedizolid, Sutezolid and Delpazolid Against Slowly Growing Mycobacteria Isolated in Beijing, China.	Yu X, Huo F, Wang F, Wen S, Jiang G, Xue Y, Dong L, Zhao L, Zhu R, Huang H.	Infect Drug Resist	10.2147/idr.s332835	2021
Pathogenicity	Does Phage Therapy Need a Pan-Phage?	Bozidis P, Markou E, Gouni A, Gartzonika K.	Pathogens	10.3390/pathogens13060522	2024
Pathogenicity	In Vitro Activities of Bedaquiline and Delamanid against Nontuberculous Mycobacteria Isolated in Beijing, China.	Yu X, Gao X, Li C, Luo J, Wen S, Zhang T, Ma Y, Dong L, Wang F, Huang H.	Antimicrob Agents Chemother	10.1128/aac.00031-19	2019
	Mycobacteriophage ZoeJ: A broad host-range close relative of mycobacteriophage TM4.	Dedrick RM, Guerrero Bustamante CA, Garlena RA, Pinches RS, Cornely K, Hatfull GF.	Tuberculosis (Edinb)	10.1016/j.tube.2019.01.002	2019
	Specific Proteins in Nontuberculous Mycobacteria: New Potential Tools.	Orduna P, Castillo-Rodal AI, Mercado ME, Ponce de Leon S, Lopez-Vidal Y.	Biomed Res Int	10.1155/2015/964178	2015
Phylogeny	Identification of Mycobacterium species by comparative analysis of the dnaA gene.	Mukai T, Miyamoto Y, Yamazaki T, Makino M.	FEMS Microbiol Lett	10.1111/j.1574-6968.2005.00031.x	2006
Phylogeny	Biochip system for rapid and accurate identification of mycobacterial species from isolates and sputum.	Zhu L, Jiang G, Wang S, Wang C, Li Q, Yu H, Zhou Y, Zhao B, Huang H, Xing W, Mitchelson K, Cheng J, Zhao Y, Guo Y.	J Clin Microbiol	10.1128/jcm.00158-10	2010
	Prospecting environmental mycobacteria: combined molecular approaches reveal unprecedented diversity.	Pontiroli A, Khera TT, Oakley BB, Mason S, Dowd SE, Travis ER, Erenso G, Aseffa A, Courtenay O, Wellington EM.	PLoS One	10.1371/journal.pone.0068648	2013
Phylogeny	Characterization of a trinucleotide repeat sequence (CGG)5 and potential use in restriction fragment length polymorphism typing of Mycobacterium tuberculosis.	Otsuka Y, Parniewski P, Zwolska Z, Kai M, Fujino T, Kirikae F, Toyota E, Kudo K, Kuratsuji T, Kirikae T.	J Clin Microbiol	10.1128/jcm.42.8.3538-3548.2004	2004
Phylogeny	The division between fast- and slow-growing species corresponds to natural relationships among the mycobacteria.	Stahl DA, Urbance JW.	J Bacteriol	10.1128/jb.172.1.116-124.1990	1990
Pathogenicity	Dual-probe assay for rapid detection of drug-resistant Mycobacterium tuberculosis by real-time PCR.	Wada T, Maeda S, Tamaru A, Imai S, Hase A, Kobayashi K.	J Clin Microbiol	10.1128/jcm.42.11.5277-5285.2004	2004
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
	Compilation of 5S rRNA and 5S rRNA gene sequences.	Specht T, Wolters J, Erdmann VA.	Nucleic Acids Res	10.1093/nar/18.suppl.2215	1990
	Bovine Tuberculosis in Wild Boar (Sus scrofa) in Slovenia.	Pate M, Zajc U, Pirs T, Ocepek M, Krt B.	J Wildl Dis	10.7589/jwd-d-23-00123	2024
	Prevalence of nontuberculous mycobacteria and the emergence of rare species in Henan Province, China.	Hongmei S, Ruixia L, Jiankang L, Han W, Chang Z, Yan MY, Kang WZ, Li LF, Zhi DC, Xin L.	Epidemiol Infect	10.1017/s095026882400061x	2024
	Intestinal nontuberculous mycobacteria infection: A case report.	Xu Y, Yang J, Cui L, Huang C, Wu C.	Medicine (Baltimore)	10.1097/md.0000000000036954	2024
	Diagnostic value of nanopore sequencing technology in nontuberculous mycobacterial pulmonary disease.	Lin WH, Tang F, Liu SS.	Am J Transl Res	10.62347/hhrh8076	2024
	Presence of Non-Tuberculous Mycobacteria Including Mycobacterium avium subsp. paratuberculosis Associated with Environmental Amoebae.	Rochard V, Cochard T, Crapart S, Delafont V, Moyen JL, Hechard Y, Biet F.	Animals (Basel)	10.3390/ani13111781	2023
Genetics	Isolation and genetic analysis of mycobacteria from suspect tuberculous lesions in slaughtered cattle from Wolaita, Ethiopia.	Zaba MY, Neway S, Farrell D, Denion E, Perets V, Tilahun M, Bobosha K, Cassidy JP, Asmare A, Gordon SV, WHO, WHO.	Access Microbiol	10.1099/acmi.0.000915.v3	2025
Genetics	Clinicopathological characteristics and diagnostic performance of metagenomic pathogen detection technology in mycobacterial infections among HIV patients.	Li M, Chen J, Zhang L, Chen X, Zhou J, Liu F, Zhou X, Xiao J, Yang K, Qi L, Han X, Liu T, Zhao H, Zhou Z, Chen X, Sun L.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1584189	2025
	Absence of Tuberculosis-Causing Mycobacteria from Slaughtered Livestock Tissues and Environmental Samples, Gauteng Province, South Africa.	Mareledwane V, Adesiyun AA, Hlokwe TM.	Int J Microbiol	10.1155/2024/4636652	2024
	Revolutionizing chronic endometritis diagnosis: real-time polymerase chain reaction unveils microbial pathogens in Indian women with abnormal bleeding and reproductive challenges.	Nandagopal M, Rajan N R, Padhiar C, Abhaya M, Bansal U, Ghambir P.	AJOG Glob Rep	10.1016/j.xagr.2024.100377	2024
	Flexor Tenosynovitis Caused by Mycobacterium heraklionense.	Mason C, Wong D, Lefebvre R.	J Hand Surg Glob Online	10.1016/j.jhsg.2021.12.010	2022
	Detection of wide genetic diversity and several novel strains among non-avium nontuberculous mycobacteria isolated from farmed and wild animals in Hungary.	Ronai Z, Eszterbauer E, Csivincsik A, Guti CF, Dencso L, Janosi S, Dan A.	J Appl Microbiol	10.1111/jam.13152	2016
	Linezolid-associated optic neuropathy in a pediatric patient with Mycobacterium nonchromogenicum: A case report.	Gonzalez Saldana N, Galvis Trujillo DM, Borbolla Pertierra AM, Mondragon Pineda AI, Juarez Olguin H.	Medicine (Baltimore)	10.1097/md.0000000000009200	2017
Enzymology	Presence of Mycobacterium avium subspecies and hepatitis E virus in raw meat products.	Lorencova A, Vasickova P, Makovcova J, Slana I.	J Food Prot	10.4315/0362-028x.jfp-13-252	2014
Phylogeny	Prevalence and distribution of non-tuberculous mycobacteria (NTM) in cattle, African buffaloes (Syncerus caffer) and their environments in South Africa.	Gcebe N, Rutten V, Gey van Pittius NC, Michel A.	Transbound Emerg Dis	10.1111/tbed.12133	2013
	Mycobacterial Infections in Invasive Turtle Species in Poland.	Radulski L, Krajewska-Wedzina M, Lipiec M, Weiner M, Zabost A, Augustynowicz-Kopec E.	Pathogens	10.3390/pathogens12040570	2023
	Linezolid induced optic neuropathy in a child treated for extensively drug resistant tuberculosis: A case report and review of literature.	Agashe P, Doshi A.	Saudi J Ophthalmol	10.1016/j.sjopt.2018.10.010	2019
	Diagnostic Utility of a Mycobacterium Multiplex PCR Detection Panel for Tuberculosis and Nontuberculous Mycobacterial Infections.	Uwamino Y, Aono A, Tomita Y, Morimoto K, Kawashima M, Kamata H, Sasaki Y, Nagai H, Hasegawa N, Mitarai S.	Microbiol Spectr	10.1128/spectrum.05162-22	2023
	Distribution of non-tuberculosis mycobacteria strains from suspected tuberculosis patients by heat shock protein 65 PCR-RFLP.	Nour-Neamatollahie A, Ebrahimzadeh N, Siadat SD, Vaziri F, Eslami M, Akhavan Sepahi A, Khanipour S, Masoumi M, Sakhaee F, Ghazanfari Jajin M, Bahrmand A, Fateh A.	Saudi J Biol Sci	10.1016/j.sjbs.2016.02.001	2017
Pathogenicity	Identification and pathogenicity analysis of a novel non-tuberculous mycobacterium clinical isolate with nine-antibiotic resistance.	Zhang ZY, Sun ZQ, Wang ZL, Hu HR, Wen ZL, Song YZ, Zhao JW, Wang HH, Guo XK, Zhang SL.	Clin Microbiol Infect	10.1111/j.1469-0691.2012.03818.x	2013
	Prurigo nodularis after acupuncture.	Almazan TH, Jung JY.	JAAD Case Rep	10.1016/j.jdcr.2015.08.004	2015
	Infectious tenosynovitis and osteomyelitis caused by Mycobacterium nonchromogenicum.	Eskesen AN, Skramm I, Steinbakk M.	Scand J Infect Dis	10.1080/00365540600798817	2007
Enzymology	Occurrence of Mycobacterium spp. and other pathogens in lymph nodes of slaughtered swine and wild boars (Sus scrofa).	Lara GH, Ribeiro MG, Leite CQ, Paes AC, Guazzelli A, da Silva AV, Santos AC, Listoni FJ.	Res Vet Sci	10.1016/j.rvsc.2010.06.009	2011
Enzymology	A case of Mycobacterium nonchromogenicum pulmonary infection showing multiple nodular shadows in an immunocompetent patient.	Sawai T, Inoue Y, Doi S, Izumikawa K, Ohno H, Yanagihara K, Higashiyama Y, Miyazaki Y, Hirakata Y, Tashiro T, Kohno S.	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2005.11.005	2006
Enzymology	Matrix Assisted Laser Desorption Ionization-Time-of-Flight mass spectrometry identification of Mycobacterium bovis in Bovinae.	Bacanelli G, Olarte LC, Silva MR, Rodrigues RA, Carneiro PAM, Kaneene JB, Pasquatti TN, Takatani H, Zumarraga MJ, Etges RN, Araujo FR, Verbisck NV.	J Vet Med Sci	10.1292/jvms.19-0214	2019
	Mycobacterium nonchromogenicum in nasal mucus from cattle in a herd infected with bovine tuberculosis.	McCorry TP, McCormick CM, Hughes MS, Pollock JM, Neill SD.	Vet Microbiol	10.1016/j.vetmic.2003.12.006	2004
	Identification of New Mycobacterium bovis antigens and development of a multiplexed serological bead-immunoassay for the diagnosis of bovine tuberculosis in cattle.	Moens C, Filee P, Boes A, Alie C, Dufrasne F, Andre E, Marche S, Fretin D.	PLoS One	10.1371/journal.pone.0292590	2023
	Second line molecular diagnosis for bovine tuberculosis to improve diagnostic schemes.	Michelet L, de Cruz K, Karoui C, Tambosco J, Moyen JL, Henault S, Boschiroli ML.	PLoS One	10.1371/journal.pone.0207614	2018
Enzymology	Mycobacterial synovitis caused by slow-growing nonchromogenic species: eighteen cases and a review of the literature.	Olsen RJ, Cernoch PL, Land GA.	Arch Pathol Lab Med	10.5858/2006-130-783-mscbsn	2006
Enzymology	Mycobacterium arupense in Cancer Patients: An Emerging Infection or a Commensal Organism.	Al Hamal Z, Jordan M, Hachem RY, Alawami HM, Alburki AM, Yousif A, Deshmukh P, Jiang Y, Chaftari AM, Raad II.	Medicine (Baltimore)	10.1097/md.0000000000002691	2016
	Mycobacterium tuberculosis infection in cattle from the Eastern Cape Province of South Africa.	Hlokwe TM, Said H, Gcebe N.	BMC Vet Res	10.1186/s12917-017-1220-3	2017
Enzymology	Population-based Incidence of Pulmonary Nontuberculous Mycobacterial Disease in Oregon 2007 to 2012.	Henkle E, Hedberg K, Schafer S, Novosad S, Winthrop KL.	Ann Am Thorac Soc	10.1513/annalsats.201412-559oc	2015
Enzymology	Molecular analyses of mycobacteria other than the M. tuberculosis complex isolated from Northern Ireland cattle.	Hughes MS, Ball NW, McCarroll J, Erskine M, Taylor MJ, Pollock JM, Skuce RA, Neill SD.	Vet Microbiol	10.1016/j.vetmic.2005.03.001	2005
	Comparative Genomics and Proteomic Analysis of Four Non-tuberculous Mycobacterium Species and Mycobacterium tuberculosis Complex: Occurrence of Shared Immunogenic Proteins.	Gcebe N, Michel A, Gey van Pittius NC, Rutten V.	Front Microbiol	10.3389/fmicb.2016.00795	2016
Enzymology	Chronic tenosynovitis of the hand due to Mycobacterium nonchromogenicum: use of high-performance liquid chromatography for identification of isolates.	Ridderhof JC, Wallace RJ, Kilburn JO, Butler WR, Warren NG, Tsukamura M, Steele LC, Wong ES.	Rev Infect Dis	10.1093/clinids/13.5.857	1991
Phylogeny	[Differentiation between Mycobacterium malmoense and Mycobacterium nonchromogenicum by ethambutol susceptibility].	Yamori S, Tsukamura M.	Kekkaku		1989
Phylogeny	[Identification of nontuberculous mycobacteria isolated from clinical materials and some comments on it].	Sato K, Saito H, Soejima R, Adachi M, Yamamura Y, Hirata Y, Fujisawa K, Hayashi M, Ishikawa H, Kuze A.	Kekkaku		1989
Phylogeny	A study of the taxonomy of the Mycobacterium nonchromogenicum complex and report of six cases of lung infection due to Mycobacterium nonchromogenicum.	Tsukamura M, Kita N, Otsuka W, Shimoide H.	Microbiol Immunol	10.1111/j.1348-0421.1983.tb03585.x	1983
	Comparative in-vitro activities of the new quinolone, Bay y 3118, and ciprofloxacin, sparfloxacin, tosufloxacin, CI-960 and CI-990.	Bauernfeind A.	J Antimicrob Chemother	10.1093/jac/31.4.505	1993
Phylogeny	Numerical classification of 280 strains of slowly growing mycobacteria. Proposal of Mycobacterium tuberculosis series, Mycobacterium avium series, and Mycobacterium nonchromogenicum series.	Tsukamura M.	Microbiol Immunol	10.1111/j.1348-0421.1983.tb00591.x	1983
	Mycobacteria isolated from deer in New Zealand from 1970-1983.	de Lisle GW, Havill PF.	N Z Vet J	10.1080/00480169.1985.35198	1985
Phylogeny	Differentiation of mycobacterial species by investigation of petroleum ether-soluble sulfolipids using thin-layer chromatography after incubation with [35S]sulfate.	Tsukamura M, Mizuno S, Toyama H.	Microbiol Immunol	10.1111/j.1348-0421.1984.tb00753.x	1984
	Comparison of proteins from Mycobacterium fortuitum, Mycobacterium nonchromogenicum and Mycobacterium terrae using flat bed electrophoresis.	Vanden Berghe DA, Pattyn SR.	J Gen Microbiol	10.1099/00221287-111-2-283	1979
	Mycolic acid patterns of some species of Mycobacterium.	Minnikin DE, Minnikin SM, Parlett JH, Goodfellow M, Magnusson M.	Arch Microbiol	10.1007/bf00402005	1984
	Isolation and detection of Mycobacterium avium subsp. paratuberculosis (MAP) from cattle in Ireland using both traditional culture and molecular based methods.	Douarre PE, Cashman W, Buckley J, Coffey A, O'Mahony JM.	Gut Pathog	10.1186/1757-4749-2-11	2010
	Inhibition of the proliferative response of peripheral blood lymphocytes to mycobacterial or fungal antigens by co-stimulation with antigens from various mycobacterial species.	Bahr GM, Rook GA, Stanford JL.	Immunology		1981
Enzymology	BactQuant: an enhanced broad-coverage bacterial quantitative real-time PCR assay.	Liu CM, Aziz M, Kachur S, Hsueh PR, Huang YT, Keim P, Price LB.	BMC Microbiol	10.1186/1471-2180-12-56	2012
Phylogeny	Non-tuberculous Mycobacteria in South African Wildlife: Neglected Pathogens and Potential Impediments for Bovine Tuberculosis Diagnosis.	Gcebe N, Hlokwe TM.	Front Cell Infect Microbiol	10.3389/fcimb.2017.00015	2017
Metabolism	Sulfatase-activated fluorophores for rapid discrimination of mycobacterial species and strains.	Beatty KE, Williams M, Carlson BL, Swarts BM, Warren RM, van Helden PD, Bertozzi CR.	Proc Natl Acad Sci U S A	10.1073/pnas.1222041110	2013
	Evidence of the presence of IS1245 and IS1311 or closely related insertion elements in nontuberculous mycobacteria outside of the Mycobacterium avium complex.	Keller AP, Beggs ML, Amthor B, Bruns F, Meissner P, Haas WH.	J Clin Microbiol	10.1128/jcm.40.5.1869-1872.2002	2002
Pathogenicity	Relatively alcohol-resistant mycobacteria are emerging pathogens in patients receiving acupuncture treatment.	Woo PC, Leung KW, Wong SS, Chong KT, Cheung EY, Yuen KY.	J Clin Microbiol	10.1128/jcm.40.4.1219-1224.2002	2002
Pathogenicity	Activities of clarithromycin against eight slowly growing species of nontuberculous mycobacteria, determined by using a broth microdilution MIC system.	Brown BA, Wallace RJ, Onyi GO.	Antimicrob Agents Chemother	10.1128/aac.36.9.1987	1992
Phylogeny	Evaluation of the new GenoType Mycobacterium assay for identification of mycobacterial species.	Russo C, Tortoli E, Menichella D.	J Clin Microbiol	10.1128/jcm.44.2.334-339.2006	2006
Enzymology	Reverse transcription-PCR detection of Mycobacterium leprae in clinical specimens.	Kurabachew M, Wondimu A, Ryon JJ.	J Clin Microbiol	10.1128/jcm.36.5.1352-1356.1998	1998
	Highly accurate antibody assays for early and rapid detection of tuberculosis in African and Asian elephants.	Greenwald R, Lyashchenko O, Esfandiari J, Miller M, Mikota S, Olsen JH, Ball R, Dumonceaux G, Schmitt D, Moller T, Payeur JB, Harris B, Sofranko D, Waters WR, Lyashchenko KP.	Clin Vaccine Immunol	10.1128/cvi.00038-09	2009
Enzymology	Clinical evaluation of the BDProbeTec strand displacement amplification assay for rapid diagnosis of tuberculosis.	Bergmann JS, Woods GL.	J Clin Microbiol	10.1128/jcm.36.9.2766-2768.1998	1998
Enzymology	Occurrence of mycobacteria in water treatment lines and in water distribution systems.	Le Dantec C, Duguet JP, Montiel A, Dumoutier N, Dubrou S, Vincent V.	Appl Environ Microbiol	10.1128/aem.68.11.5318-5325.2002	2002
Enzymology	Enhanced Amplified Mycobacterium Tuberculosis Direct Test for detection of Mycobacterium tuberculosis complex in positive BACTEC 12B broth cultures of respiratory specimens.	Bergmann JS, Woods GL.	J Clin Microbiol	10.1128/jcm.37.6.2099-2101.1999	1999
	Delayed hypersensitivity responses in mice and guinea pigs to Mycobacterium leprae, Mycobacterium vaccae, and Mycobacterium nonchromogenicum cytoplasmic proteins.	Watson SR, Morrison NE, Collins FM.	Infect Immun	10.1128/iai.25.1.229-236.1979	1979
Phylogeny	Heterogeneity of RNA polymerase gene (rpoB) sequences of Mycobacterium gordonae clinical isolates identified with a DNA probe kit and by conventional methods.	Itoh S, Kazumi Y, Abe C, Takahashi M.	J Clin Microbiol	10.1128/jcm.41.4.1656-1663.2003	2003
Enzymology	Novel diagnostic algorithm for identification of mycobacteria using genus-specific amplification of the 16S-23S rRNA gene spacer and restriction endonucleases.	Roth A, Reischl U, Streubel A, Naumann L, Kroppenstedt RM, Habicht M, Fischer M, Mauch H.	J Clin Microbiol	10.1128/jcm.38.3.1094-1104.2000	2000
Phylogeny	Detection of a new Mycobacterium species in wild striped bass in the Chesapeake Bay.	Heckert RA, Elankumaran S, Milani A, Baya A.	J Clin Microbiol	10.1128/jcm.39.2.710-715.2001	2001
Enzymology	Clinical application of PCR-restriction enzyme pattern analysis for rapid identification of aerobic actinomycete isolates.	Wilson RW, Steingrube VA, Brown BA, Wallace RJ.	J Clin Microbiol	10.1128/jcm.36.1.148-152.1998	1998
Phylogeny	Application of the Sherlock Mycobacteria Identification System using high-performance liquid chromatography in a clinical laboratory.	Kellogg JA, Bankert DA, Withers GS, Sweimler W, Kiehn TE, Pfyffer GE.	J Clin Microbiol	10.1128/jcm.39.3.964-970.2001	2001
	Clinically applicable multiplex PCR for four middle ear pathogens.	Hendolin PH, Paulin L, Ylikoski J.	J Clin Microbiol	10.1128/jcm.38.1.125-132.2000	2000
	Antimicrobial susceptibility testing, drug resistance mechanisms, and therapy of infections with nontuberculous mycobacteria.	Brown-Elliott BA, Nash KA, Wallace RJ.	Clin Microbiol Rev	10.1128/cmr.05030-11	2012
Enzymology	Multicenter evaluation of mycobacteria identification by PCR restriction enzyme analysis in laboratories from Latin America and the Caribbean.	Leao SC, Bernardelli A, Cataldi A, Zumarraga M, Robledo J, Realpe T, Mejia GI, da Silva Telles MA, Chimara E, Velazco M, Fernandez J, Rodrigues PA, Guerrero MI, Leon CI, Porras TB, Rastogi N, Goh KS, Suffys P, da Silva Rocha A, dos Santos Netto D, Ritacco V, Lopez B, Barrera L, Palomino JC, Martin A, Portaels F	J Microbiol Methods	10.1016/j.mimet.2004.11.015	2004
	Correction for Vasireddy et al., Mycobacterium arupense, Mycobacterium heraklionense, and a Newly Proposed Species, "Mycobacterium virginiense" sp. nov., but Not Mycobacterium nonchromogenicum, as Species of the Mycobacterium terrae Complex Causing Tenosynovitis and Osteomyelitis.	Vasireddy R, Vasireddy S, Brown-Elliott BA, Wengenack NL, Eke UA, Benwill JL, Turenne C, Wallace RJ.	J Clin Microbiol	10.1128/jcm.02290-16	2017
Phylogeny	Mycobacterium arupense, Mycobacterium heraklionense, and a Newly Proposed Species, "Mycobacterium virginiense" sp. nov., but Not Mycobacterium nonchromogenicum, as Species of the Mycobacterium terrae Complex Causing Tenosynovitis and Osteomyelitis.	Vasireddy R, Vasireddy S, Brown-Elliott BA, Wengenack NL, Eke UA, Benwill JL, Turenne C, Wallace RJ.	J Clin Microbiol	10.1128/jcm.00198-16	2016
Phylogeny	Mycobacterium senuense sp. nov., a slowly growing, non-chromogenic species closely related to the Mycobacterium terrae complex.	Mun HS, Park JH, Kim H, Yu HK, Park YG, Cha CY, Kook YH, Kim BJ.	Int J Syst Evol Microbiol	10.1099/ijs.0.65374-0	2008
Phylogeny	Mycobacterium hiberniae sp. nov.	Kazda J, Cooney R, Monaghan M, Quinn PJ, Stackebrandt E, Dorsch M, Daffe M, Muller K, Cook BR, Tarnok ZS.	Int J Syst Bacteriol	10.1099/00207713-43-2-352	1993
Phylogeny	Mycobacterium arupense sp. nov., a non-chromogenic bacterium isolated from clinical specimens.	Cloud JL, Meyer JJ, Pounder JI, Jost KC, Sweeney A, Carroll KC, Woods GL	Int J Syst Evol Microbiol	10.1099/ijs.0.64194-0	2006

References

#11562	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 44164
#20009	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36353	; Curators of the CIP;
#49063	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 28009
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68379	Automatically annotated from API Coryne .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#121346	Collection of Institut Pasteur ; Curators of the CIP; CIP 106811
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mycobacterium nonchromogenicum (DSM 44164, ATCC 19530, ATCC 23067)

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