Mycobacterium intracellulare (DSM 44161, ATCC 23068, NCTC 10425)

Name: Mycobacterium intracellulare (DSM 44161, ATCC 23068, NCTC 10425)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 8404

Type strain

Strain Designation N100616

Culture col. no. DSM 44161 ATCC 23068 NCTC 10425 N100616

NCBI tax ID(s) 1767

Special Collections DSMZ

History <- ATCC; ATCC 23068 <- NCTC; NCTC 10425 <- M. Tsukamura; N100616 (Mycobacterium americae) <- K. Takeya;

Links

Mycobacterium intracellulare N100616 is a human pathogen that was isolated from human isolate.

human pathogen Bacteria

Name and taxonomic classification

SI-ID 37889

ATCC 23068,NCTC 10425,DSM 44161

@ref 20215

Last LPSN update 2026-02-09 11:19:42

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Mycobacteriales

Family Mycobacteriaceae

Genus Mycobacterium

Species Mycobacterium intracellulare

Full scientific name Mycobacterium intracellulare corrig. (Cuttino and McCabe 1949) Runyon 1965 (Approved Lists 1980)

Synonyms (3)

"Nocardia intracellularis"
Mycobacterium intracellularis
Mycobacterium paraintracellulare

BacDive ID	Other strains from **Mycobacterium intracellulare** (21)	Type strain
8405	M. intracellulare 2123, DSM 44365
8406	M. intracellulare DSM 44655
145189	M. intracellulare CCUG 27852
145260	M. intracellulare CCUG 28000
145261	M. intracellulare CCUG 28001, ATCC 35772, TMC 1469
145625	M. intracellulare CCUG 29033, ATCC 23426
163838	M. intracellulare JCM 30618
163839	M. intracellulare JCM 30619
173070	M. intracellulare 140310075, CRBIP7.149, CIPT 149, Howell P-42
173071	M. intracellulare 140310076, CRBIP7.150, CIPT 150, TMC 1466
173072	M. intracellulare 140310077, CRBIP7.151, CIPT 151
173073	M. intracellulare 140310079, CRBIP7.152, CIPT 152
173074	M. intracellulare P-54, 140310080, CRBIP7.153, CIPT 153
173075	M. intracellulare 140310081, 4990, CRBIP7.154, CIPT 154
173076	M. intracellulare 140310082, W552, CRBIP7.155, CIPT 155
173077	M. intracellulare 140310083, AT545, CRBIP7.156, CIPT 156
173078	M. intracellulare 23393, 140310085, CRBIP7.158, CIPT 158
173079	M. intracellulare 140310086, 12646, CRBIP7.159, CIPT 159
173080	M. intracellulare 140310090, 9055, CRBIP7.162, CIPT 162
173081	M. intracellulare 140310097, CRBIP7.168, CIPT 168
173082	M. intracellulare 140310078, CRBIP7.169, CIPT 169, TMC 1475

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
11559	MIDDLEBROOK MEDIUM (DSMZ Medium 645)		Medium recipe at MediaDive	Name: MIDDLEBROOK MEDIUM (DSMZ Medium 645) Composition: Bacto Middlebrook 7H10 agar 20.9945 g/l Glycerol Distilled water
11559	LÖWENSTEIN-JENSEN MEDIUM (DSMZ Medium 354)		Medium recipe at MediaDive	Name: LÖWENSTEIN-JENSEN MEDIUM (DSMZ Medium 354) Composition: Potato flour 18.6104 g/l L-Asparagin 2.23325 g/l KH2PO4 1.55087 g/l Mg-citrate 0.372208 g/l Malachite green 0.248139 g/l MgSO4 0.148883 g/l Glycerol Fresh egg mixture Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
11559	positive	growth	37

Physiology and metabolism

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2
#Host	#Human

Isolation

11559

Sample typehuman isolate

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Pathogenicity animal	Biosafety level	Biosafety level comment
11559			2	Risk group (German classification) According to TRBA 466

Sequence information

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Proposed Mechanism for Emodin as Agent for Methicillin Resistant Staphylococcus Aureus: In Vitro Testing and In Silico Study.	Ghoneim MM, Al-Serwi RH, El-Sherbiny M, El-Ghaly EM, Hamad AE, Abdelgawad MA, Ragab EA, Bukhari SI, Bukhari K, Elokely K, Nael MA.	Curr Issues Mol Biol	10.3390/cimb44100307	2022
	Potential Medicinal Fungi from Freshwater Environments as Resources of Bioactive Compounds.	Cicero I, Mirabile G, Venturella G.	J Fungi (Basel)	10.3390/jof11010054	2025
	Recent Trends in Synthesis of Chloramphenicol New Derivatives.	Tevyashova AN.	Antibiotics (Basel)	10.3390/antibiotics10040370	2021
	Antimycobacterial and antimalarial activities of endophytic fungi associated with the ancient and narrowly endemic neotropical plant Vellozia gigantea from Brazil.	Ferreira MC, Cantrell CL, Wedge DE, Goncalves VN, Jacob MR, Khan S, Rosa CA, Rosa LH.	Mem Inst Oswaldo Cruz	10.1590/0074-02760170144	2017
	Evaluation of Triazole and Isoxazole Derivatives as Potential Anti-infective Agents.	Tarawneh AH, Al-Momani LAA, Leon F, Jain SK, Gadetskaya AV, Abu-Orabi ST, Tekwani BL, Cutler SJ.	Med Chem Res	10.1007/s00044-018-2146-4	2018
	Hypericum Essential Oils-Composition and Bioactivities: An Update (2012-2022).	Grafakou ME, Barda C, Karikas GA, Skaltsa H.	Molecules	10.3390/molecules27165246	2022
	Promising selective MAO-B inhibition by sesamin, a lignan from Zanthoxylum flavum stems.	Mohamed SM, Chaurasiya ND, Mohamed NM, Bayoumi SAL, Tekwani BL, Ross SA.	Saudi Pharm J	10.1016/j.jsps.2020.02.001	2020
	Perylenequinones from an endophytic Alternaria sp. of Pinus ponderosa.	Tantry MA, Idris AS, Williamson JS, Shafi T, Dar JS, Malik TA, Ganai BA, Shawl AS.	Heliyon	10.1016/j.heliyon.2018.e01046	2018
Enzymology	Secondary metabolites from the fungus Emericella nidulans.	Tarawneh AH, Leon F, Radwan MM, Rosa LH, Cutler SJ.	Nat Prod Commun	10.1177/1934578x1300800925	2013
	New secondary metabolites from bioactive extracts of the fungus Armillaria tabescens.	Herath HM, Jacob M, Wilson AD, Abbas HK, Nanayakkara NP.	Nat Prod Res	10.1080/14786419.2012.738206	2013
Phylogeny	Newly Generated Atractylon Derivatives in Processed Rhizomes of Atractylodes macrocephala Koidz.	Zhai C, Zhao J, Chittiboyina AG, Meng Y, Wang M, Khan IA.	Molecules	10.3390/molecules25245904	2020
Enzymology	Antibacterial secondary metabolites from the cave sponge Xestospongia sp.	Ankisetty S, Slattery M.	Mar Drugs	10.3390/md10051037	2012
Phylogeny	In vitro evaluation of aliphatic fatty alcohol metabolites of Perseaamericana seed as potential antimalarial and antimicrobial agents.	Falodun A, Erharuyi O, Imieje V, Ahomafor J, Akunyuli C, Jacobs M, Khan S, Hamann MT, Langer P.	Niger J Biotechnol		2014
Pathogenicity	Evaluation of three medicinal plant extracts against Plasmodium falciparum and selected microganisms.	Falodun A, Imieje V, Erharuyi O, Ahomafor J, Jacob MR, Khan SI, Hamann MT.	Afr J Tradit Complement Altern Med	10.4314/ajtcam.v11i4.22	2014
Pathogenicity	Antimicrobial Constituents from Machaerium Pers.: Inhibitory Activities and Synergism of Machaeriols and Machaeridiols against Methicillin-Resistant Staphylococcus aureus, Vancomycin-Resistant Enterococcus faecium, and Permeabilized Gram-Negative Pathogens.	Muhammad I, Jacob MR, Ibrahim MA, Raman V, Kumarihamy M, Wang M, Al-Adhami T, Hind C, Clifford M, Martin B, Zhao J, Sutton JM, Rahman KM.	Molecules	10.3390/molecules25246000	2020
	New alpha-Tetralone Galloylglucosides from the Fresh Pericarps of Juglans sigillata.	Liu Q, Zhao P, Li XC, Jacob MR, Yang CR, Zhang YJ.	Helv Chim Acta	10.1002/hlca.200900177	2010
	In vitro and in vivo evaluation of select kahalalide F analogs with antitumor and antifungal activities.	Shilabin AG, Hamann MT.	Bioorg Med Chem	10.1016/j.bmc.2011.06.050	2011
	Sulfated phenolic compounds from Limonium caspium: Isolation, structural elucidation, and biological evaluation.	Gadetskaya AV, Tarawneh AH, Zhusupova GE, Gemejiyeva NG, Cantrell CL, Cutler SJ, Ross SA.	Fitoterapia	10.1016/j.fitote.2015.05.017	2015
	Antiparasitic and antimicrobial indolizidines from the leaves of Prosopis glandulosa var. glandulosa.	Rahman AA, Samoylenko V, Jacob MR, Sahu R, Jain SK, Khan SI, Tekwani BL, Muhammad I.	Planta Med	10.1055/s-0030-1270906	2011
	New triterpenoidal saponins from Koelreuteria paniculata.	Mostafa AE, El-Hela AA, Mohammad AI, Cutler SJ, Ross SA.	Phytochem Lett	10.1016/j.phytol.2016.07.008	2016
	Ursolic Acid, a Natural Pentacylcic Triterpene from Ochrosia elliptica and Its Role in The Management of Certain Neglected Tropical Diseases.	Labib RM, Ebada SS, Youssef FS, Ashour ML, Ross SA.	Pharmacogn Mag	10.4103/0973-1296.192207	2016
	Synthesis, stability and mechanistic studies of potent anticryptococcal hexapeptides.	Shenmar K, Sharma KK, Wangoo N, Maurya IK, Kumar V, Khan SI, Jacob MR, Tikoo K, Jain R.	Eur J Med Chem	10.1016/j.ejmech.2017.03.046	2017
	Isolation and characterization of new secondary metabolites from Asphodelus microcarpus.	Ghoneim MM, Elokely KM, El-Hela AA, Mohammad AE, Jacob M, Cutler SJ, Doerksen RJ, Ross SA.	Med Chem Res	10.1007/s00044-014-0928-x	2014
	Antimicrobial and antiparasitic abietane diterpenoids from the roots of Clerodendrum eriophyllum.	Machumi F, Samoylenko V, Yenesew A, Derese S, Midiwo JO, Wiggers FT, Jacob MR, Tekwani BL, Khan SI, Walker LA, Muhammad I.	Nat Prod Commun	10.1177/1934578x1000500605	2010
Enzymology	Asphodosides A-E, anti-MRSA metabolites from Asphodelus microcarpus.	Ghoneim MM, Elokely KM, El-Hela AA, Mohammad AE, Jacob M, Radwan MM, Doerksen RJ, Cutler SJ, Ross SA.	Phytochemistry	10.1016/j.phytochem.2014.06.011	2014
	Nigrosphaerin A a new isochromene derivative from the endophytic fungus Nigrospora sphaerica.	Metwaly AM, Metwaly AM, Kadry HA, El-Hela AA, Mohammad AI, Ma G, Cutler SJ, Ross SA.	Phytochem Lett	10.1016/j.phytol.2013.09.001	2014
	New thiophene and flavonoid from Tagetes minuta leaves growing in Saudi Arabia.	Al-Musayeib NM, Mohamed GA, Ibrahim SR, Ross SA.	Molecules	10.3390/molecules19032819	2014
	Antimicrobial, antiparasitic and cytotoxic spermine alkaloids from Albizia schimperiana.	Samoylenko V, Jacob MR, Khan SI, Zhao J, Tekwani BL, Midiwo JO, Walker LA, Muhammad I.	Nat Prod Commun	10.1177/1934578x0900400611	2009
Pathogenicity	Methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and Enterococcus faecium active dimeric isobutyrylphloroglucinol from Ivesia gordonii.	Ahmed MH, Ibrahim MA, Zhang J, Melek FR, El-Hawary SS, Jacob MR, Muhammad I.	Nat Prod Commun	10.1177/1934578x1400900223	2014
	Phytochemical, Antimicrobial and Antiplasmodial Investigations of Terminalia brownii.	Machumi F, Midiwo JO, Jacob MR, Khan SI, Tekwani BL, Zhang J, Walker LA, Muhammad I.	Nat Prod Commun	10.1177/1934578x1300800619	2013
	Structure determination and absolute configuration of cannabichromanone derivatives from high potency Cannabis sativa.	Ahmed SA, Ross SA, Slade D, Radwan MM, Khan IA, Elsohly MA.	Tetrahedron Lett	10.1016/j.tetlet.2008.07.178	2008
Enzymology	N-Methyl-4-hydroxy-2-pyridinone analogues from Fusarium oxysporum.	Jayasinghe L, Abbas HK, Jacob MR, Herath WH, Nanayakkara NP.	J Nat Prod	10.1021/np050487v	2006
	Isolation of antileishmanial, antimalarial and antimicrobial metabolites from Jatropha multifida.	Falodun A, Imieje V, Erharuyi O, Joy A, Langer P, Jacob M, Khan S, Abaldry M, Hamann M.	Asian Pac J Trop Biomed	10.12980/apjtb.4.2014c1312	2014
	Minor oxygenated cannabinoids from high potency Cannabis sativa L.	Ahmed SA, Ross SA, Slade D, Radwan MM, Khan IA, ElSohly MA.	Phytochemistry	10.1016/j.phytochem.2015.04.007	2015
Enzymology	Biologically active cannabinoids from high-potency Cannabis sativa.	Radwan MM, Elsohly MA, Slade D, Ahmed SA, Khan IA, Ross SA.	J Nat Prod	10.1021/np900067k	2009
Enzymology	Cannabinoid ester constituents from high-potency Cannabis sativa.	Ahmed SA, Ross SA, Slade D, Radwan MM, Zulfiqar F, Matsumoto RR, Xu YT, Viard E, Speth RC, Karamyan VT, ElSohly MA.	J Nat Prod	10.1021/np070454a	2008
	Bioactive (+)-manzamine A and (+)-8-hydroxymanzamine A tertiary bases and salts from Acanthostrongylophora ingens and their preparations.	Samoylenko V, Khan SI, Jacoba MR, Tekwani BL, Walker LA, Hufford CD, Muhammad I.	Nat Prod Commun	10.1177/1934578x0900400204	2009
	Synthesis and biological evaluation of tricyclic guanidine analogues of batzelladine K for antimalarial, antileishmanial, antibacterial, antifungal, and anti-HIV activities.	Ahmed N, Brahmbhatt KG, Khan SI, Jacob M, Tekwani BL, Sabde S, Mitra D, Singh IP, Khan IA, Bhutani KK.	Chem Biol Drug Des	10.1111/cbdd.1427	2013
Enzymology	Indolizidine, antiinfective and antiparasitic compounds from Prosopis glandulosa var. glandulosa.	Samoylenko V, Ashfaq MK, Jacob MR, Tekwani BL, Khan SI, Manly SP, Joshi VC, Walker LA, Muhammad I.	J Nat Prod	10.1021/np800653z	2009
	Discovery of 3,3'-diindolylmethanes as potent antileishmanial agents.	Bharate SB, Bharate JB, Khan SI, Tekwani BL, Jacob MR, Mudududdla R, Yadav RR, Singh B, Sharma PR, Maity S, Singh B, Khan IA, Vishwakarma RA.	Eur J Med Chem	10.1016/j.ejmech.2013.02.024	2013
Metabolism	Microbial metabolism of cannflavin A and B isolated from Cannabis sativa.	Ibrahim AK, Radwan MM, Ahmed SA, Slade D, Ross SA, ElSohly MA, Khan IA.	Phytochemistry	10.1016/j.phytochem.2010.02.011	2010
Metabolism	Complex marine natural products as potential epigenetic and production regulators of antibiotics from a marine Pseudomonas aeruginosa.	Wang B, Waters AL, Sims JW, Fullmer A, Ellison S, Hamann MT.	Microb Ecol	10.1007/s00248-013-0213-4	2013
Enzymology	New anthraquinone derivatives from Geosmithia lavendula.	Malak LG, Bishay DW, Abdel-Baky AM, Moharram AM, Cutler SJ, Ross SA.	Nat Prod Commun	10.1177/1934578x1300800215	2013
Metabolism	New ursane triterpenoids from Ficus pandurata and their binding affinity for human cannabinoid and opioid receptors.	Khedr AI, Ibrahim SR, Mohamed GA, Ahmed HE, Ahmad AS, Ramadan MA, El-Baky AE, Yamada K, Ross SA.	Arch Pharm Res	10.1007/s12272-016-0784-y	2016
	Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents.	Zhu XY, Mardenborough LG, Li S, Khan A, Zhang W, Fan P, Jacob M, Khan S, Walker L, Ablordeppey SY.	Bioorg Med Chem	10.1016/j.bmc.2006.10.062	2007
	Antimicrobial and antiprotozoal activities of secondary metabolites from the fungus Eurotium repens.	Gao J, Radwan MM, Leon F, Wang X, Jacob MR, Tekwani BL, Khan SI, Lupien S, Hill RA, Dugan FM, Cutler HG, Cutler SJ.	Med Chem Res	10.1007/s00044-011-9798-7	2012
	2-N-Methyl modifications and SAR studies of manzamine A.	Ibrahim MA, Shilabin AG, Prasanna S, Jacob M, Khan SI, Doerksen RJ, Hamann MT.	Bioorg Med Chem	10.1016/j.bmc.2008.05.079	2008
Enzymology	Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.	Yang F, Hamann MT, Zou Y, Zhang MY, Gong XB, Xiao JR, Chen WS, Lin HW.	J Nat Prod	10.1021/np2009016	2012
	Phytochemical investigation of Cycas circinalis and Cycas revoluta leaflets: moderately active antibacterial biflavonoids.	Moawad A, Hetta M, Zjawiony JK, Jacob MR, Hifnawy M, Marais JP, Ferreira D.	Planta Med	10.1055/s-0029-1240743	2010
Enzymology	Bioactive 1,4-dihydroxy-5-phenyl-2-pyridinone alkaloids from Septoria pistaciarum.	Kumarihamy M, Fronczek FR, Ferreira D, Jacob M, Khan SI, Nanayakkara NP.	J Nat Prod	10.1021/np1000939	2010
	Structure-activity relationship and mechanism of action studies of manzamine analogues for the control of neuroinflammation and cerebral infections.	Peng J, Kudrimoti S, Prasanna S, Odde S, Doerksen RJ, Pennaka HK, Choo YM, Rao KV, Tekwani BL, Madgula V, Khan SI, Wang B, Mayer AM, Jacob MR, Tu LC, Gertsch J, Hamann MT.	J Med Chem	10.1021/jm900672t	2010
Enzymology	Antiprotozoal and antimicrobial compounds from the plant pathogen Septoria pistaciarum.	Kumarihamy M, Khan SI, Jacob M, Tekwani BL, Duke SO, Ferreira D, Nanayakkara NP.	J Nat Prod	10.1021/np200940b	2012
	An entry to curcuphenol/elvirol core structures via a retro-Aldol reaction.	Plano MF, Labadie GR, Jacob MR, Tekwani BL, Cravero RM.	Chem Biodivers	10.1002/cbdv.201000160	2011
	Non-cannabinoid constituents from a high potency Cannabis sativa variety.	Radwan MM, Elsohly MA, Slade D, Ahmed SA, Wilson L, El-Alfy AT, Khan IA, Ross SA.	Phytochemistry	10.1016/j.phytochem.2008.07.010	2008
	Antiprotozoal, anticancer and antimicrobial activities of dihydroartemisinin acetal dimers and monomers.	Slade D, Galal AM, Gul W, Radwan MM, Ahmed SA, Khan SI, Tekwani BL, Jacob MR, Ross SA, Elsohly MA.	Bioorg Med Chem	10.1016/j.bmc.2009.10.019	2009
Pathogenicity	Lysosome and HER3 (ErbB3) selective anticancer agent kahalalide F: semisynthetic modifications and antifungal lead-exploration studies.	Shilabin AG, Kasanah N, Wedge DE, Hamann MT.	J Med Chem	10.1021/jm061288r	2007
Pathogenicity	Rapid radiometric method for determining drug susceptibility of Mycobacterium avium-intracellulare.	Yangco BG, Eikman EA, Solomon DA, Deresinski SC, Madden JA.	Antimicrob Agents Chemother	10.1128/aac.19.4.534	1981
	Antimicrobial Lipids from Plants and Marine Organisms: An Overview of the Current State-of-the-Art and Future Prospects.	Alves E, Dias M, Lopes D, Almeida A, Domingues MDR, Rey F.	Antibiotics (Basel)	10.3390/antibiotics9080441	2020
Metabolism	Synthesis, antimalarial, antileishmanial, antimicrobial, cytotoxicity, and methemoglobin (MetHB) formation activities of new 8-quinolinamines.	Kaur K, Patel SR, Patil P, Jain M, Khan SI, Jacob MR, Tekwani BL, Jain R.	Bioorg Med Chem	10.1016/j.bmc.2006.10.036	2007
	Synthesis, antiprotozoal, antimicrobial, beta-hematin inhibition, cytotoxicity and methemoglobin (MetHb) formation activities of bis(8-aminoquinolines).	Kaur K, Jain M, Khan SI, Jacob MR, Tekwani BL, Singh S, Singh PP, Jain R.	Bioorg Med Chem	10.1016/j.bmc.2010.11.036	2011
Phylogeny	Multiplex PCR for identifying mycobacterial isolates.	Cormican M, Glennon M, Riain UN, Flynn J.	J Clin Pathol	10.1136/jcp.48.3.203	1995
Enzymology	Isolation of Mycobacterium paratuberculosis from milk by immunomagnetic separation.	Grant IR, Ball HJ, Rowe MT.	Appl Environ Microbiol	10.1128/aem.64.9.3153-3158.1998	1998
Enzymology	Maximizing capture efficiency and specificity of magnetic separation for Mycobacterium avium subsp. paratuberculosis cells.	Foddai A, Elliott CT, Grant IR.	Appl Environ Microbiol	10.1128/aem.01432-10	2010
Enzymology	Use of polymerase chain reaction for early identification of Mycobacterium tuberculosis in positive cultures.	Cormican MG, Barry T, Gannon F, Flynn J.	J Clin Pathol	10.1136/jcp.45.7.601	1992

References

#11559	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 44161
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Mycobacterium intracellulare (DSM 44161, ATCC 23068, NCTC 10425)

Name and taxonomic classification

Morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Isolation, sampling and environmental information

Isolation source categories

Isolation

Interaction and safety

Risk assessment

Sequence information

Genome-based predictions

Literature

Literature

References

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