Micromonospora echinospora subsp. echinospora (DSM 43816, ATCC 15837, CBS 619.66)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	11289
  multimedia content:	DSM_43816-1.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_43816-1.jpg
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	11289
  multimedia content:	DSM_43816.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_43816.jpg
  caption:	Medium 554 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
11289	N-Z-AMINE-MEDIUM (DSMZ Medium 554)		Medium recipe at MediaDive	Name: N-Z-AMINE-MEDIUM (DSMZ Medium 554) Composition: Starch 20.0 g/l Agar 20.0 g/l Glucose 10.0 g/l N-Z amine 5.0 g/l Yeast extract 5.0 g/l CaCO3 1.0 g/l Distilled water
19959	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19959	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19959	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19959	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19959	ISP 6			Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19959	ISP 7			Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
11289	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 20.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Compound production

Halophily

Observation

Tolerance

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
19959	22599 ChEBI	arabinose	+
68368	29016 ChEBI	arginine	-	hydrolysis	from API 20E
19959	62968 ChEBI	cellulose	-
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
19959	28757 ChEBI	fructose	-
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
19959	17234 ChEBI	glucose	+
68368	25094 ChEBI	lysine	-	degradation	from API 20E
19959	29864 ChEBI	mannitol	-
19959	17268 ChEBI	myo-inositol	-
68368	18257 ChEBI	ornithine	-	degradation	from API 20E
19959	16634 ChEBI	raffinose	+
19959	26546 ChEBI	rhamnose	+
19959	17992 ChEBI	sucrose	+
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	-	hydrolysis	from API 20E
19959	18222 ChEBI	xylose	-

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
67770	17833 ChEBI	gentamicin
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68368	arginine dihydrolase	-	3.5.3.6	from API 20E
68382	beta-galactosidase	+	3.2.1.23	from API zym
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68382	beta-glucosidase	+	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68382	cystine arylamidase	+	3.4.11.3	from API zym
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	+		from API zym
68368	gelatinase	+		from API 20E
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68368	lysine decarboxylase	-	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
68368	ornithine decarboxylase	-	4.1.1.17	from API 20E
68382	trypsin	+	3.4.21.4	from API zym
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	-	3.5.1.5	from API 20E
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	ppGpp biosynthesis	100	4 of 4
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	cardiolipin biosynthesis	100	7 of 7
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	pentose phosphate pathway	100	11 of 11
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	octane oxidation	100	3 of 3
66794	aspartate and asparagine metabolism	100	9 of 9
66794	starch degradation	100	10 of 10
66794	biotin biosynthesis	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	valine metabolism	100	9 of 9
66794	palmitate biosynthesis	100	22 of 22
66794	acetate fermentation	100	4 of 4
66794	enterobactin biosynthesis	100	3 of 3
66794	adipate degradation	100	2 of 2
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	ceramide biosynthesis	100	1 of 1
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	suberin monomers biosynthesis	100	2 of 2
66794	sulfopterin metabolism	100	4 of 4
66794	coenzyme A metabolism	100	4 of 4
66794	aerobactin biosynthesis	100	1 of 1
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	folate polyglutamylation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	ribulose monophosphate pathway	100	2 of 2
66794	cellulose degradation	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	Entner Doudoroff pathway	90	9 of 10
66794	serine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	ketogluconate metabolism	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	flavin biosynthesis	86.67	13 of 15
66794	tetrahydrofolate metabolism	85.71	12 of 14
66794	citric acid cycle	85.71	12 of 14
66794	glutathione metabolism	85.71	12 of 14
66794	photosynthesis	85.71	12 of 14
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	phenol degradation	85	17 of 20
66794	urea cycle	84.62	11 of 13
66794	NAD metabolism	83.33	15 of 18
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	tryptophan metabolism	81.58	31 of 38
66794	purine metabolism	80.85	76 of 94
66794	metabolism of amino sugars and derivatives	80	4 of 5
66794	vitamin K metabolism	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	3-chlorocatechol degradation	80	4 of 5
66794	propionate fermentation	80	8 of 10
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	alanine metabolism	79.31	23 of 29
66794	arginine metabolism	79.17	19 of 24
66794	heme metabolism	78.57	11 of 14
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	methionine metabolism	76.92	20 of 26
66794	glycolysis	76.47	13 of 17
66794	vitamin B12 metabolism	76.47	26 of 34
66794	degradation of sugar acids	76	19 of 25
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	glutamate and glutamine metabolism	75	21 of 28
66794	glycogen biosynthesis	75	3 of 4
66794	lipid metabolism	74.19	23 of 31
66794	non-pathway related	73.68	28 of 38
66794	proline metabolism	72.73	8 of 11
66794	propanol degradation	71.43	5 of 7
66794	myo-inositol biosynthesis	70	7 of 10
66794	vitamin B1 metabolism	69.23	9 of 13
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	lysine metabolism	69.05	29 of 42
66794	histidine metabolism	68.97	20 of 29
66794	pyrimidine metabolism	68.89	31 of 45
66794	degradation of sugar alcohols	68.75	11 of 16
66794	carotenoid biosynthesis	68.18	15 of 22
66794	oxidative phosphorylation	68.13	62 of 91
66794	degradation of hexoses	66.67	12 of 18
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	d-mannose degradation	66.67	6 of 9
66794	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
66794	cyanate degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	tyrosine metabolism	64.29	9 of 14
66794	degradation of pentoses	64.29	18 of 28
66794	metabolism of disaccharids	63.64	7 of 11
66794	d-xylose degradation	63.64	7 of 11
66794	dTDPLrhamnose biosynthesis	62.5	5 of 8
66794	cysteine metabolism	61.11	11 of 18
66794	glycogen metabolism	60	3 of 5
66794	arachidonate biosynthesis	60	3 of 5
66794	3-phenylpropionate degradation	60	9 of 15
66794	lipoate biosynthesis	60	3 of 5
66794	gallate degradation	60	3 of 5
66794	aclacinomycin biosynthesis	57.14	4 of 7
66794	nitrate assimilation	55.56	5 of 9
66794	4-hydroxymandelate degradation	55.56	5 of 9
66794	glycine metabolism	50	5 of 10
66794	toluene degradation	50	2 of 4
66794	butanoate fermentation	50	2 of 4
66794	vitamin E metabolism	50	2 of 4
66794	quinate degradation	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	lactate fermentation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	catecholamine biosynthesis	50	2 of 4
66794	4-hydroxyphenylacetate degradation	50	5 of 10
66794	kanosamine biosynthesis II	50	1 of 2
66794	CMP-KDO biosynthesis	50	2 of 4
66794	coenzyme M biosynthesis	50	5 of 10
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	sulfate reduction	46.15	6 of 13
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	vitamin B6 metabolism	45.45	5 of 11
66794	lipid A biosynthesis	44.44	4 of 9
66794	arachidonic acid metabolism	44.44	8 of 18
66794	androgen and estrogen metabolism	43.75	7 of 16
66794	D-cycloserine biosynthesis	40	2 of 5
66794	elloramycin biosynthesis	40	2 of 5
66794	bacilysin biosynthesis	40	2 of 5
66794	phenylpropanoid biosynthesis	38.46	5 of 13
66794	carnitine metabolism	37.5	3 of 8
66794	dolichyl-diphosphooligosaccharide biosynthesis	36.36	4 of 11
66794	ascorbate metabolism	36.36	8 of 22
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	sulfoquinovose degradation	33.33	1 of 3
66794	pantothenate biosynthesis	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	polyamine pathway	30.43	7 of 23
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	cholesterol biosynthesis	27.27	3 of 11
66794	alginate biosynthesis	25	1 of 4
66794	diterpene phytoalexins precursors biosynthesis	25	4 of 16
66794	daunorubicin biosynthesis	22.22	2 of 9

API 20E

API zym

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	IMG-taxon 2622736613 annotated assembly for Micromonospora echinospora DSM 43816	chromosome	GCA_900091495	1877.5	2622736613	1877	83.62
67770	ASM226684v1 assembly for Micromonospora echinospora ATCC 15837	scaffold	GCA_002266845	1877.7	2855711692	1877	51.78

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Micromonospora echinospora ATCC 15837 16S-23S ribosomal RNA intergenic spacer	AY371887	361		1877
11289	M.echinospora 16S rRNA gene (isolate DSM 43816)	X92607	1465		1877
67770	Micromonospora echinospora echinospora 16S ribosomal RNA gene sequence	U58532	1409		1877

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	A two-component system MechNtrB/MechNtrC related to nitrogen metabolism regulation in Micromonospora echinospora DSM43816.	Long Y, Lu J, Leng S, Li C, Ni H, Zou L, Wu Z, Long ZE.	Front Microbiol	10.3389/fmicb.2025.1678324	2025
	A two-stage metabolome refining pipeline for natural products discovery.	Zhang R, Wang B, Wang C, Huang K, Li Z, Yang J, Kuang J, Ren L, Wu M, Zhang K, Xie H, Liu Y, Wu M, Wu Y, Xu F.	Synth Syst Biotechnol	10.1016/j.synbio.2025.01.006	2025
	Extending the Salinilactone Family.	Schlawis C, Harig T, Ehlers S, Guillen-Matus DG, Creamer KE, Jensen PR, Schulz S.	Chembiochem	10.1002/cbic.201900764	2020
	Furaquinocins K and L: Novel Naphthoquinone-Based Meroterpenoids from Streptomyces sp. Je 1-369.	Tistechok S, Stierhof M, Myronovskyi M, Zapp J, Gromyko O, Luzhetskyy A.	Antibiotics (Basel)	10.3390/antibiotics11111587	2022
	Comparative Genomic Analysis of Soil Dwelling Bacteria Utilizing a Combinational Codon Usage and Molecular Phylogenetic Approach Accentuating on Key Housekeeping Genes.	Saha J, Saha BK, Pal Sarkar M, Roy V, Mandal P, Pal A.	Front Microbiol	10.3389/fmicb.2019.02896	2019
Transcriptome	Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space.	Helbert W, Poulet L, Drouillard S, Mathieu S, Loiodice M, Couturier M, Lombard V, Terrapon N, Turchetto J, Vincentelli R, Henrissat B.	Proc Natl Acad Sci U S A	10.1073/pnas.1815791116	2019
	Induced systemic resistance against Botrytis cinerea by Micromonospora strains isolated from root nodules.	Martinez-Hidalgo P, Garcia JM, Pozo MJ.	Front Microbiol	10.3389/fmicb.2015.00922	2015
	Genetic recombination in Micromonospora.	Beretta M, Betti M, Polsinelli M.	J Bacteriol	10.1128/jb.107.2.415-419.1971	1971
Genetics	Evidence for Divergence of the Genus 'Solwaraspora' Within the Bacterial Family Micromonosporaceae.	Porter HI, Alas I, Krull NK, Braun DR, Rajski SR, Murphy BT, Bugni TS.	Microorganisms	10.3390/microorganisms13071576	2025
	Sequential Reconstruction of Calicheamicin gamma1 I Iodo-Thiobenzoate by Selective Carrier Protein Trapping Reveals a Flavin-Dependent Iodinase.	Pang F, Townsend CA.	Angew Chem Int Ed Engl	10.1002/anie.202506825	2025
	S-Bridged Thioether and Structure-Diversified Angucyclinone Derivatives from the South China Sea-Derived Micromonospora echinospora SCSIO 04089.	Fang Z, Jiang X, Zhang Q, Zhang L, Zhang W, Yang C, Zhang H, Zhu Y, Zhang C.	J Nat Prod	10.1021/acs.jnatprod.0c00719	2020
	Glycosylation of Semi-Synthetic Isoflavene Phenoxodiol with a Recombinant Glycosyltransferase from Micromonospora echinospora ATCC 27932.	Seo M, Seol Y, Park JW.	J Microbiol Biotechnol	10.4014/jmb.2111.11032	2022
Genetics	Stepwise increase of fidaxomicin in an engineered heterologous host Streptomyces albus through multi-level metabolic engineering.	Xie H, Su YT, Bu QT, Li YP, Zhao QW, Du YL, Li YQ.	Synth Syst Biotechnol	10.1016/j.synbio.2024.06.004	2024
Biotechnology	GC/MS Fatty Acid Profile of Marine-Derived Actinomycetes from Extreme Environments: Chemotaxonomic Insights and Biotechnological Potential.	Cunha MB, Jorge AF, Nunes MJ, Sousa JR, Lanca MJ, Gomes da Silva M, Gaudencio SP.	Mar Drugs	10.3390/md23010001	2024
	Numerical Modeling of Gentamicin Transport in Agricultural Soils: Implications for Environmental Pollution	Morales-Duran N, Fuentes S, Garcia-Gallego J, Trevino-Resendez J, Garcia-Espinoza J, Morones-Ramirez R, Chavez C.	Antibiotics (Basel)		2025
	Enediyne natural product biosynthesis unified by a diiodotetrayne intermediate.	Gui C, Kalkreuter E, Lauterbach L, Yang D, Shen B.	Nat Chem Biol	10.1038/s41589-024-01636-y	2024
	In Vitro Anti-Glioblastoma Activity of Echinocereus engelmannii- and Echinocereus pectinatus-Associated Bacterial Endophyte Extracts.	Delgado-Miranda AL, Gomez-Flores R, Rodriguez-Garza NE, Perez-Gonzalez O, Tamez-Guerra P, Caballero-Hernandez D, Clark-Perez DL, Quintanilla-Licea R, Garcia A, Romo-Saenz CI.	Life (Basel)	10.3390/life15040519	2025
	From Natural Microbe Screening to Sustained Chitinase Activity in Exogenous Hosts.	Chaulagain D, Shamabadi NS, Leslie SA, Karig DK.	ACS Synth Biol	10.1021/acssynbio.3c00637	2024
	In Vitro Antitumor Activity of Endophytic and Rhizosphere Gram-Positive Bacteria from Ibervillea sonorae (S. Watson) Greene against L5178Y-R Lymphoma Cells.	Romero-Arguelles R, Romo-Saenz CI, Moran-Santibanez K, Tamez-Guerra P, Quintanilla-Licea R, Orozco-Flores AA, Ramirez-Villalobos JM, Tamez-Guerra R, Rodriguez-Padilla C, Gomez-Flores R.	Int J Environ Res Public Health	10.3390/ijerph19020894	2022
	Biosynthesis of the Unusual Epoxy Isonitrile-Containing Antibiotics Aerocyanidin and Amycomicin.	Zheng Z, Clardy J, Liu HW.	J Am Chem Soc	10.1021/jacs.4c06411	2024
	Strategic and Chemical Advances in Antibody-Drug Conjugates.	Alradwan IA, Alnefaie MK, Al Fayez N, Aodah AH, Majrashi MA, Alturki M, Fallatah MM, Almughem FA, Tawfik EA, Alshehri AA.	Pharmaceutics	10.3390/pharmaceutics17091164	2025
Phylogeny	Niche-Aware Metagenomic Screening for Enzyme Methioninase Illuminates Its Contribution to Metabolic Syntrophy.	Khamespanah E, Asad S, Vanak Z, Mehrshad M.	Microb Ecol	10.1007/s00248-024-02458-0	2024
Enzymology	Identification and characterization of a methionine gamma-lyase in the calicheamicin biosynthetic cluster of Micromonospora echinospora.	Song H, Xu R, Guo Z.	Chembiochem	10.1002/cbic.201402489	2015
Metabolism	Structural Basis of the Selectivity of GenN, an Aminoglycoside N-Methyltransferase Involved in Gentamicin Biosynthesis.	Bury PDS, Huang F, Li S, Sun Y, Sun Y, Leadlay PF, Dias MVB.	ACS Chem Biol	10.1021/acschembio.7b00466	2017
	Long-Chain Alkyl Cyanides: Unprecedented Volatile Compounds Released by Pseudomonas and Micromonospora Bacteria.	Montes Vidal D, von Rymon-Lipinski AL, Ravella S, Groenhagen U, Herrmann J, Zaburannyi N, Zarbin PH, Varadarajan AR, Ahrens CH, Weisskopf L, Muller R, Schulz S.	Angew Chem Int Ed Engl	10.1002/anie.201611940	2017
	Overproduction of gentamicin B in industrial strain Micromonospora echinospora CCTCC M 2018898 by cloning of the missing genes genR and genS.	Chang Y, Chai B, Ding Y, He M, Zheng L, Teng Y, Deng Z, Yu Y, Liu T.	Metab Eng Commun	10.1016/j.mec.2019.e00096	2019
	Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering.	Wei Z, Shi X, Lian R, Wang W, Hong W, Guo S.	Antibiotics (Basel)	10.3390/antibiotics8040267	2019
Metabolism	Genetic engineering combined with random mutagenesis to enhance G418 production in Micromonospora echinospora.	Ni X, Sun Z, Zhang H, He H, Ji Z, Xia H.	J Ind Microbiol Biotechnol	10.1007/s10295-014-1479-3	2014
	Structural and Functional Basis of GenB2 Isomerase Activity from Gentamicin Biosynthesis.	Oliveira GS, Dos S Bury P, Huang F, Li Y, Araujo NC, Zhou J, Sun Y, Leeper FJ, Leadlay PF, Dias MVB.	ACS Chem Biol	10.1021/acschembio.4c00334	2024
Proteome	An off-pathway folding intermediate of an acyl carrier protein domain coexists with the folded and unfolded states under native conditions.	Lim J, Xiao T, Fan J, Yang D.	Angew Chem Int Ed Engl	10.1002/anie.201308512	2014
	Deoxyribonuclease inhibitors.	Kolarevic A, Yancheva D, Kocic G, Smelcerovic A.	Eur J Med Chem	10.1016/j.ejmech.2014.07.040	2014
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Phylogeny	Genome-based classification of micromonosporae with a focus on their biotechnological and ecological potential.	Carro L, Nouioui I, Sangal V, Meier-Kolthoff JP, Trujillo ME, Montero-Calasanz MDC, Sahin N, Smith DL, Kim KE, Peluso P, Deshpande S, Woyke T, Shapiro N, Kyrpides NC, Klenk HP, Goker M, Goodfellow M.	Sci Rep	10.1038/s41598-017-17392-0	2018
Metabolism	Radical SAM enzymes in the biosynthesis of sugar-containing natural products.	Ruszczycky MW, Ogasawara Y, Liu HW.	Biochim Biophys Acta	10.1016/j.bbapap.2011.11.006	2012
Metabolism	Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.	Kaysser L, Wemakor E, Siebenberg S, Salas JA, Sohng JK, Kammerer B, Gust B.	Appl Environ Microbiol	10.1128/aem.02740-09	2010
	The ClusPro web server for protein-protein docking.	Kozakov D, Hall DR, Xia B, Porter KA, Padhorny D, Yueh C, Beglov D, Vajda S.	Nat Protoc	10.1038/nprot.2016.169	2017
	Recent Advances in the Development of Antineoplastic Agents Derived from Natural Products.	Trendowski M.	Drugs	10.1007/s40265-015-0489-4	2015
Metabolism	Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.	Lorenzana LM, Perez-Redondo R, Santamarta I, Martin JF, Liras P.	J Bacteriol	10.1128/jb.186.11.3431-3438.2004	2004
	Detection of transcriptional triggers in the dynamics of microbial growth: application to the respiratorily versatile bacterium Shewanella oneidensis.	Beg QK, Zampieri M, Klitgord N, Collins SB, Altafini C, Serres MH, Segre D.	Nucleic Acids Res	10.1093/nar/gks467	2012
Metabolism	Metabolism of endogenous trehalose by Streptomyces griseus spores and by spores or cells of other actinomycetes.	McBride MJ, Ensign JC.	J Bacteriol	10.1128/jb.169.11.5002-5007.1987	1987
Enzymology	SDR enzymes oxidize specific lipidic alkynylcarbinols into cytotoxic protein-reactive species.	Demange P, Joly E, Marcoux J, Zanon PRA, Listunov D, Rulliere P, Barthes C, Noirot C, Izquierdo JB, Rozie A, Pradines K, Hee R, de Brito MV, Marcellin M, Serre RF, Bouchez O, Burlet-Schiltz O, Oliveira MCF, Ballereau S, Bernardes-Genisson V, Maraval V, Calsou P, Hacker SM, Genisson Y, Chauvin R, Britton S.	Elife	10.7554/elife.73913	2022
Metabolism	Functional angucycline-like antibiotic gene cluster in the terminal inverted repeats of the Streptomyces ambofaciens linear chromosome.	Pang X, Aigle B, Girardet JM, Mangenot S, Pernodet JL, Decaris B, Leblond P.	Antimicrob Agents Chemother	10.1128/aac.48.2.575-588.2004	2004
	Genes for production of the enediyne antitumor antibiotic C-1027 in Streptomyces globisporus are clustered with the cagA gene that encodes the C-1027 apoprotein.	Liu W, Shen B.	Antimicrob Agents Chemother	10.1128/aac.44.2.382-392.2000	2000
Enzymology	Differentiation and protease production in Micromonospora echinospora (ATCC 15837).	Hoskisson PA, Sharples GP, Hobbs G	Antonie Van Leeuwenhoek	10.1007/s10482-005-9001-6	2005
Metabolism	Modulation of glycogen and trehalose levels in Micromonospora echinospora (ATCC 15837).	Hoskisson PA, England R, Sharples GP, Hobbs G	Antonie Van Leeuwenhoek	10.1023/B:ANTO.0000047920.48459.63	2004
Metabolism	The importance of amino acids as carbon sources for Micromonospora echinospora (ATCC 15837).	Hoskisson PA, Sharples GP, Hobbs G	Lett Appl Microbiol	10.1046/j.1472-765x.2003.01306.x	2003
Metabolism	Antibiotic production, accumulation of intracellular carbon reserves, and sporulation in Micromonospora echinospora (ATCC 15837).	Hoskisson PA, Hobbs G, Sharples GP	Can J Microbiol		2001
Cultivation	Response of Micromonospora echinospora (NCIMB 12744) spores to heat treatment with evidence of a heat activation phenomenon.	Hoskisson PA, Hobbs G, Sharples GP	Lett Appl Microbiol	10.1046/j.1472-765x.2000.00680.x	2000
	Micromonospora cathayae sp. nov., isolated from the rhizosphere soil of Cathaya argyrophylla.	Long PL, Fu L, Xiao Y, Gao J.	Int J Syst Evol Microbiol	10.1099/ijsem.0.006332	2024
Genetics	Discovery and biosynthetic assessment of 'Streptomyces ortus' sp. nov. isolated from a deep-sea sponge.	Williams SE, Back CR, Best E, Mantell J, Stach JEM, Williams TA, Race PR, Curnow P.	Microb Genom	10.1099/mgen.0.000996	2023
	Taxonomic description of Micromonospora reichwaldensis sp. nov. and its biosynthetic and plant growth-promoting potential.	Nouioui I, Zimmermann A, Gomez Escribano JP, Jando M, Potter G, Neumann-Schaal M, Mast Y.	Microbiol Spectr	10.1128/spectrum.02129-24	2025
Metabolism	Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. II. Taxonomic study of the producing microorganism.	Takahashi Y, Iwai Y, Omura S.	J Antibiot (Tokyo)	10.7164/antibiotics.39.1413	1986
Metabolism	Clostomicins, new antibiotics produced by Micromonospora echinospora subsp. armeniaca subsp. nov. I. Production, isolation, and physico-chemical and biological properties.	Omura S, Imamura N, Oiwa R, Kuga H, Iwata R, Masuma R, Iwai Y.	J Antibiot (Tokyo)	10.7164/antibiotics.39.1407	1986
Phylogeny	Micromonospora tulbaghiae sp. nov., isolated from the leaves of wild garlic, Tulbaghia violacea.	Kirby BM, Meyers PR	Int J Syst Evol Microbiol	10.1099/ijs.0.013243-0	2009