Micromonospora echinospora (DSM 1039, ATCC 27932, DSM 43822)

Multimedia

• @ref:	481
  multimedia content:	DSM_1039.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_1039.jpg
  caption:	Medium 554 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
481	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
481	SPORULATION-AGAR (SA) (DSMZ Medium 555)		Medium recipe at MediaDive	Name: SPORULATION-AGAR (SA) (DSMZ Medium 555) Composition: Agar 15.0 g/l Glucose 10.0 g/l Tryptone peptone 2.0 g/l Beef extract 1.0 g/l Yeast extract 1.0 g/l Distilled water FeSO4

Culture temp

Compound production

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	ppGpp biosynthesis	100	4 of 4
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	cardiolipin biosynthesis	100	7 of 7
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	pentose phosphate pathway	100	11 of 11
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	octane oxidation	100	3 of 3
66794	aspartate and asparagine metabolism	100	9 of 9
66794	starch degradation	100	10 of 10
66794	biotin biosynthesis	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	valine metabolism	100	9 of 9
66794	palmitate biosynthesis	100	22 of 22
66794	acetate fermentation	100	4 of 4
66794	enterobactin biosynthesis	100	3 of 3
66794	adipate degradation	100	2 of 2
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	ceramide biosynthesis	100	1 of 1
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	suberin monomers biosynthesis	100	2 of 2
66794	sulfopterin metabolism	100	4 of 4
66794	coenzyme A metabolism	100	4 of 4
66794	aerobactin biosynthesis	100	1 of 1
66794	formaldehyde oxidation	100	3 of 3
66794	glycine betaine biosynthesis	100	5 of 5
66794	folate polyglutamylation	100	1 of 1
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	ribulose monophosphate pathway	100	2 of 2
66794	cellulose degradation	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	Entner Doudoroff pathway	90	9 of 10
66794	serine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	molybdenum cofactor biosynthesis	88.89	8 of 9
66794	ketogluconate metabolism	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	flavin biosynthesis	86.67	13 of 15
66794	tetrahydrofolate metabolism	85.71	12 of 14
66794	citric acid cycle	85.71	12 of 14
66794	glutathione metabolism	85.71	12 of 14
66794	photosynthesis	85.71	12 of 14
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	phenol degradation	85	17 of 20
66794	urea cycle	84.62	11 of 13
66794	NAD metabolism	83.33	15 of 18
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	tryptophan metabolism	81.58	31 of 38
66794	purine metabolism	80.85	76 of 94
66794	metabolism of amino sugars and derivatives	80	4 of 5
66794	vitamin K metabolism	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	3-chlorocatechol degradation	80	4 of 5
66794	propionate fermentation	80	8 of 10
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	alanine metabolism	79.31	23 of 29
66794	arginine metabolism	79.17	19 of 24
66794	heme metabolism	78.57	11 of 14
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	methionine metabolism	76.92	20 of 26
66794	glycolysis	76.47	13 of 17
66794	vitamin B12 metabolism	76.47	26 of 34
66794	degradation of sugar acids	76	19 of 25
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	cyclohexanol degradation	75	3 of 4
66794	glutamate and glutamine metabolism	75	21 of 28
66794	glycogen biosynthesis	75	3 of 4
66794	lipid metabolism	74.19	23 of 31
66794	non-pathway related	73.68	28 of 38
66794	proline metabolism	72.73	8 of 11
66794	propanol degradation	71.43	5 of 7
66794	myo-inositol biosynthesis	70	7 of 10
66794	vitamin B1 metabolism	69.23	9 of 13
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	lysine metabolism	69.05	29 of 42
66794	histidine metabolism	68.97	20 of 29
66794	pyrimidine metabolism	68.89	31 of 45
66794	degradation of sugar alcohols	68.75	11 of 16
66794	carotenoid biosynthesis	68.18	15 of 22
66794	oxidative phosphorylation	68.13	62 of 91
66794	degradation of hexoses	66.67	12 of 18
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	d-mannose degradation	66.67	6 of 9
66794	degradation of aromatic, nitrogen containing compounds	66.67	8 of 12
66794	cyanate degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	tyrosine metabolism	64.29	9 of 14
66794	degradation of pentoses	64.29	18 of 28
66794	metabolism of disaccharids	63.64	7 of 11
66794	d-xylose degradation	63.64	7 of 11
66794	dTDPLrhamnose biosynthesis	62.5	5 of 8
66794	cysteine metabolism	61.11	11 of 18
66794	glycogen metabolism	60	3 of 5
66794	arachidonate biosynthesis	60	3 of 5
66794	3-phenylpropionate degradation	60	9 of 15
66794	lipoate biosynthesis	60	3 of 5
66794	gallate degradation	60	3 of 5
66794	aclacinomycin biosynthesis	57.14	4 of 7
66794	nitrate assimilation	55.56	5 of 9
66794	4-hydroxymandelate degradation	55.56	5 of 9
66794	glycine metabolism	50	5 of 10
66794	toluene degradation	50	2 of 4
66794	butanoate fermentation	50	2 of 4
66794	vitamin E metabolism	50	2 of 4
66794	quinate degradation	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	lactate fermentation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	catecholamine biosynthesis	50	2 of 4
66794	4-hydroxyphenylacetate degradation	50	5 of 10
66794	kanosamine biosynthesis II	50	1 of 2
66794	CMP-KDO biosynthesis	50	2 of 4
66794	coenzyme M biosynthesis	50	5 of 10
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	sulfate reduction	46.15	6 of 13
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	vitamin B6 metabolism	45.45	5 of 11
66794	lipid A biosynthesis	44.44	4 of 9
66794	arachidonic acid metabolism	44.44	8 of 18
66794	androgen and estrogen metabolism	43.75	7 of 16
66794	D-cycloserine biosynthesis	40	2 of 5
66794	elloramycin biosynthesis	40	2 of 5
66794	bacilysin biosynthesis	40	2 of 5
66794	phenylpropanoid biosynthesis	38.46	5 of 13
66794	carnitine metabolism	37.5	3 of 8
66794	dolichyl-diphosphooligosaccharide biosynthesis	36.36	4 of 11
66794	ascorbate metabolism	36.36	8 of 22
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	sulfoquinovose degradation	33.33	1 of 3
66794	pantothenate biosynthesis	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	polyamine pathway	30.43	7 of 23
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	cholesterol biosynthesis	27.27	3 of 11
66794	alginate biosynthesis	25	1 of 4
66794	diterpene phytoalexins precursors biosynthesis	25	4 of 16
66794	daunorubicin biosynthesis	22.22	2 of 9

Isolation source categories

Isolation

Risk assessment

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
481	M.rhodorangea 16S rRNA gene	X92612	1466		1877

Literature

Topic	Title	Authors	Journal	DOI	Year
Biotechnology	Recent advances in the biosynthesis and production optimization of gentamicin: A critical review.	Xu F, Hu K, Mohsin A, Wu J, Su L, Wang Y, Ben R, Gao H, Tian X, Chu J.	Synth Syst Biotechnol	10.1016/j.synbio.2024.11.003	2025
	Intertidal marine sediment harbours Actinobacteria with promising bioactive and biosynthetic potential.	Jose PA, Jha B.	Sci Rep	10.1038/s41598-017-09672-6	2017
Metabolism	Glycosylation of Semi-Synthetic Isoflavene Phenoxodiol with a Recombinant Glycosyltransferase from Micromonospora echinospora ATCC 27932.	Seo M, Seol Y, Park JW	J Microbiol Biotechnol	10.4014/jmb.2111.11032	2022
	Kinetic studies on recombinant UDP-glucose: sterol 3-O-beta-glycosyltransferase from Micromonospora rhodorangea and its bioconversion potential.	Hoang NH, Huong NL, Kim B, Park JW	AMB Express	10.1186/s13568-016-0224-x	2016
Metabolism	Biochemical Characterization of Recombinant UDP-Glucose:Sterol 3-O-Glycosyltransferase from Micromonospora rhodorangea ATCC 31603 and Enzymatic Biosynthesis of Sterol-3-O-beta-Glucosides.	Hoang NH, Hong SY, Huong NL, Park JW	J Microbiol Biotechnol	10.4014/jmb.1511.11003	2016
Metabolism	Biotransformation of sisomicin to gentamicin C2b.	Lee BK, Bailey JV, Condon RG, Marquez JA, Wagman GH, Weinstein MJ	Antimicrob Agents Chemother	10.1128/AAC.12.3.335	1977
	Taxonomic description of Micromonospora reichwaldensis sp. nov. and its biosynthetic and plant growth-promoting potential.	Nouioui I, Zimmermann A, Gomez Escribano JP, Jando M, Potter G, Neumann-Schaal M, Mast Y.	Microbiol Spectr	10.1128/spectrum.02129-24	2025