Actinoplanes friuliensis (DSM 45797, CCUG 63250, JCM 31203)

Cell morphology

Colony morphology

Multimedia

• @ref:	18228
  multimedia content:	DSM_45797.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_45797.jpg
  caption:	Medium 553 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
18228	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
18228	GPHF-MEDIUM (DSMZ Medium 553)		Medium recipe at MediaDive	Name: GPHF-MEDIUM (DSMZ Medium 553) Composition: Agar 20.0 g/l Glucose 10.0 g/l Beef extract 5.0 g/l Yeast extract 5.0 g/l Casein peptone 5.0 g/l CaCl2 x 2 H2O 0.74 g/l Distilled water
18228	TRYPTICASE SOY BROTH AGAR (DSMZ Medium 535)		Medium recipe at MediaDive	Name: TRYPTICASE SOY BROTH AGAR (DSMZ Medium 535) Composition: Trypticase soy broth 30.0 g/l Agar 15.0 g/l Distilled water
18228	BHI MEDIUM (DSMZ Medium 215)		Medium recipe at MediaDive	Name: BHI MEDIUM (DSMZ Medium 215) Composition: Brain heart infusion 37.0 g/l Distilled water

Culture temp

Oxygen tolerance

Compound production

Observation

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	acetate fermentation	100	4 of 4
66794	adipate degradation	100	2 of 2
66794	myo-inositol biosynthesis	100	10 of 10
66794	formaldehyde oxidation	100	3 of 3
66794	coenzyme A metabolism	100	4 of 4
66794	methylglyoxal degradation	100	5 of 5
66794	glycogen metabolism	100	5 of 5
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	cardiolipin biosynthesis	100	7 of 7
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	starch degradation	100	10 of 10
66794	biotin biosynthesis	100	4 of 4
66794	kanosamine biosynthesis II	100	2 of 2
66794	valine metabolism	100	9 of 9
66794	resorcinol degradation	100	2 of 2
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	ppGpp biosynthesis	100	4 of 4
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	folate polyglutamylation	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	palmitate biosynthesis	100	22 of 22
66794	isoleucine metabolism	100	8 of 8
66794	cellulose degradation	100	5 of 5
66794	ceramide biosynthesis	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	mannosylglycerate biosynthesis	100	2 of 2
66794	NAD metabolism	94.44	17 of 18
66794	glutathione metabolism	92.86	13 of 14
66794	vitamin B12 metabolism	91.18	31 of 34
66794	pentose phosphate pathway	90.91	10 of 11
66794	Entner Doudoroff pathway	90	9 of 10
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	serine metabolism	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	glycolysis	88.24	15 of 17
66794	degradation of sugar acids	88	22 of 25
66794	degradation of sugar alcohols	87.5	14 of 16
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	pyrimidine metabolism	86.67	39 of 45
66794	flavin biosynthesis	86.67	13 of 15
66794	alanine metabolism	86.21	25 of 29
66794	purine metabolism	86.17	81 of 94
66794	photosynthesis	85.71	12 of 14
66794	heme metabolism	85.71	12 of 14
66794	propanol degradation	85.71	6 of 7
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	phenylalanine metabolism	84.62	11 of 13
66794	urea cycle	84.62	11 of 13
66794	leucine metabolism	84.62	11 of 13
66794	tryptophan metabolism	84.21	32 of 38
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	glutamate and glutamine metabolism	82.14	23 of 28
66794	d-xylose degradation	81.82	9 of 11
66794	3-chlorocatechol degradation	80	4 of 5
66794	4-hydroxyphenylacetate degradation	80	8 of 10
66794	glycine betaine biosynthesis	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	histidine metabolism	79.31	23 of 29
66794	citric acid cycle	78.57	11 of 14
66794	degradation of pentoses	78.57	22 of 28
66794	d-mannose degradation	77.78	7 of 9
66794	degradation of hexoses	77.78	14 of 18
66794	allantoin degradation	77.78	7 of 9
66794	4-hydroxymandelate degradation	77.78	7 of 9
66794	methionine metabolism	76.92	20 of 26
66794	oxidative phosphorylation	76.92	70 of 91
66794	non-pathway related	76.32	29 of 38
66794	arginine metabolism	75	18 of 24
66794	cyclohexanol degradation	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	dTDPLrhamnose biosynthesis	75	6 of 8
66794	CMP-KDO biosynthesis	75	3 of 4
66794	phenol degradation	75	15 of 20
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	lipid metabolism	74.19	23 of 31
66794	3-phenylpropionate degradation	73.33	11 of 15
66794	proline metabolism	72.73	8 of 11
66794	metabolism of disaccharids	72.73	8 of 11
66794	cysteine metabolism	72.22	13 of 18
66794	tyrosine metabolism	71.43	10 of 14
66794	tetrahydrofolate metabolism	71.43	10 of 14
66794	propionate fermentation	70	7 of 10
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	vitamin B1 metabolism	69.23	9 of 13
66794	sulfoquinovose degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	chlorophyll metabolism	66.67	12 of 18
66794	IAA biosynthesis	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	lysine metabolism	64.29	27 of 42
66794	ketogluconate metabolism	62.5	5 of 8
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	phenylacetate degradation (aerobic)	60	3 of 5
66794	lipoate biosynthesis	60	3 of 5
66794	gallate degradation	60	3 of 5
66794	vitamin K metabolism	60	3 of 5
66794	degradation of aromatic, nitrogen containing compounds	58.33	7 of 12
66794	polyamine pathway	56.52	13 of 23
66794	androgen and estrogen metabolism	56.25	9 of 16
66794	carotenoid biosynthesis	54.55	12 of 22
66794	phenylpropanoid biosynthesis	53.85	7 of 13
66794	phosphatidylethanolamine bioynthesis	53.85	7 of 13
66794	lactate fermentation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	ethanol fermentation	50	1 of 2
66794	sphingosine metabolism	50	3 of 6
66794	ribulose monophosphate pathway	50	1 of 2
66794	toluene degradation	50	2 of 4
66794	coenzyme M biosynthesis	50	5 of 10
66794	pantothenate biosynthesis	50	3 of 6
66794	carnitine metabolism	50	4 of 8
66794	quinate degradation	50	1 of 2
66794	glycine metabolism	50	5 of 10
66794	vitamin E metabolism	50	2 of 4
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	sulfate reduction	46.15	6 of 13
66794	vitamin B6 metabolism	45.45	5 of 11
66794	ascorbate metabolism	45.45	10 of 22
66794	arachidonic acid metabolism	44.44	8 of 18
66794	nitrate assimilation	44.44	4 of 9
66794	lipid A biosynthesis	44.44	4 of 9
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	aclacinomycin biosynthesis	42.86	3 of 7
66794	bacilysin biosynthesis	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	creatinine degradation	40	2 of 5
66794	hydrogen production	40	2 of 5
66794	enterobactin biosynthesis	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	mevalonate metabolism	28.57	2 of 7
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	alginate biosynthesis	25	1 of 4
66794	catecholamine biosynthesis	25	1 of 4
66794	daunorubicin biosynthesis	22.22	2 of 9

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM49475v1 assembly for Actinoplanes friuliensis DSM 7358	complete	GCA_000494755	1246995.3	2554235379	1246995	93.25

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
18228	Actinoplanes friuliensis partial 16S rRNA gene, type strain HAG 010964T	FR733685	1506		1246995

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	PhytoPipe: a phytosanitary pipeline for plant pathogen detection and diagnosis using RNA-seq data.	Hu X, Hurtado-Gonzales OP, Adhikari BN, French-Monar RD, Malapi M, Foster JA, McFarland CD.	BMC Bioinformatics	10.1186/s12859-023-05589-2	2023
Genetics	Genome mining for drug discovery: cyclic lipopeptides related to daptomycin.	Baltz RH.	J Ind Microbiol Biotechnol	10.1093/jimb/kuab020	2021
Genetics	Metagenomic analysis of soybean endosphere microbiome to reveal signatures of microbes for health and disease.	Chouhan U, Gamad U, Choudhari JK.	J Genet Eng Biotechnol	10.1186/s43141-023-00535-4	2023
Genetics	Actinobacterial community in Shuanghe Cave using culture-dependent and -independent approaches.	Long Y, Jiang J, Hu X, Zhou J, Hu J, Zhou S.	World J Microbiol Biotechnol	10.1007/s11274-019-2713-y	2019
	Integrated Omics-Based Discovery of Bioactive Halogenated Metabolites from the Deep-Sea Streptomyces sp. B188M101.	Oluwabusola ET, Jackson SA, Brunati C, Gackstatter S, Vedder H, Iorio M, Chawande G, Margassery LM, Nguyen GS, Clarke DJ, Ebel R, Jaspars M, Dobson ADW.	Mar Drugs	10.3390/md23090362	2025
Metabolism	Development of cultivation strategies for friulimicin production in Actinoplanes friuliensis.	Steinkamper A, Schmid J, Schwartz D, Biener R.	J Biotechnol	10.1016/j.jbiotec.2014.12.013	2015
	Optimization of the precursor supply for an enhanced FK506 production in Streptomyces tsukubaensis.	Schulz S, Schall C, Stehle T, Breitmeyer C, Krysenko S, Mitulski A, Wohlleben W.	Front Bioeng Biotechnol	10.3389/fbioe.2022.1067467	2022
	Streptomyces uses both polar and dispersed cell wall synthesis during exploratory growth.	Zambri MP, Baglio CR, Irazoki O, Jones SE, Garner EC, Cava F, Elliot MA.	Nat Microbiol	10.1038/s41564-025-02080-x	2025
	The ssgB gene is required for the early stages of sporangium formation in Actinoplanes missouriensis.	Akutsu T, Tezuka T, Maruko M, Hirata A, Ohnishi Y.	J Bacteriol	10.1128/jb.00428-23	2024
	Surfactin Shows Relatively Low Antimicrobial Activity against Bacillus subtilis and Other Bacterial Model Organisms in the Absence of Synergistic Metabolites.	Lilge L, Ersig N, Hubel P, Aschern M, Pillai E, Klausmann P, Pfannstiel J, Henkel M, Morabbi Heravi K, Hausmann R.	Microorganisms	10.3390/microorganisms10040779	2022
	Exploring the diversity and antimicrobial potential of actinomycetes isolated from different environments in Saudi Arabia: a systematic review.	Helmi NR.	Front Microbiol	10.3389/fmicb.2025.1568899	2025
	Comparative analysis of transcriptional activities of heterologous promoters in the rare actinomycete Actinoplanes friuliensis.	Wagner N, Osswald C, Biener R, Schwartz D.	J Biotechnol	10.1016/j.jbiotec.2009.05.002	2009
Phylogeny	Genome guided investigation of antibiotics producing actinomycetales strain isolated from a Macau mangrove ecosystem.	Hu D, Chen Y, Sun C, Jin T, Fan G, Liao Q, Mok KM, Lee MS.	Sci Rep	10.1038/s41598-018-32076-z	2018
Metabolism	Analysis of RegA, a pathway-specific regulator of the friulimicin biosynthesis in Actinoplanes friuliensis.	Nolden S, Wagner N, Biener R, Schwartz D.	J Biotechnol	10.1016/j.jbiotec.2008.12.013	2009
Biotechnology	An Overview of Microorganisms Immobilized in a Gel Structure for the Production of Precursors, Antibiotics, and Valuable Products.	Berillo D, Malika T, Baimakhanova BB, Sadanov AK, Berezin VE, Trenozhnikova LP, Baimakhanova GB, Amangeldi AA, Kerimzhanova B.	Gels	10.3390/gels10100646	2024
Phylogeny	Isolation, antibacterial screening, and identification of bioactive cave dwelling bacteria in Fiji.	Pipite A, Lockhart PJ, McLenachan PA, Christi K, Kumar D, Prasad S, Subramani R.	Front Microbiol	10.3389/fmicb.2022.1012867	2022
Metabolism	An acyl-CoA dehydrogenase is involved in the formation of the Delta cis3 double bond in the acyl residue of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis.	Heinzelmann E, Berger S, Muller C, Hartner T, Poralla K, Wohlleben W, Schwartz D.	Microbiology (Reading)	10.1099/mic.0.27844-0	2005
Stress	Structural and dynamic characterization of a freestanding acyl carrier protein involved in the biosynthesis of cyclic lipopeptide antibiotics.	Paul S, Ishida H, Nguyen LT, Liu Z, Vogel HJ.	Protein Sci	10.1002/pro.3138	2017
Metabolism	Streptomyces sp. VN1, a producer of diverse metabolites including non-natural furan-type anticancer compound.	Nguyen HT, Pokhrel AR, Nguyen CT, Pham VTT, Dhakal D, Lim HN, Jung HJ, Kim TS, Yamaguchi T, Sohng JK.	Sci Rep	10.1038/s41598-020-58623-1	2020
Metabolism	Genetic and Transcriptional Analyses of the Flagellar Gene Cluster in Actinoplanes missouriensis.	Jang MS, Mouri Y, Uchida K, Aizawa S, Hayakawa M, Fujita N, Tezuka T, Ohnishi Y.	J Bacteriol	10.1128/jb.00306-16	2016
	The Cell Envelope Stress Response of Bacillus subtilis towards Laspartomycin C.	Diehl A, Wood TM, Gebhard S, Martin NI, Fritz G.	Antibiotics (Basel)	10.3390/antibiotics9110729	2020
Genetics	A comprehensive metagenomics framework to characterize organisms relevant for planetary protection.	Danko DC, Sierra MA, Benardini JN, Guan L, Wood JM, Singh N, Seuylemezian A, Butler DJ, Ryon K, Kuchin K, Meleshko D, Bhattacharya C, Venkateswaran KJ, Mason CE.	Microbiome	10.1186/s40168-021-01020-1	2021
Genetics	In silico and Genetic Analyses of Cyclic Lipopeptide Synthetic Gene Clusters in Pseudomonas sp. 11K1.	Zhao H, Liu YP, Zhang LQ.	Front Microbiol	10.3389/fmicb.2019.00544	2019
Metabolism	Sequencing and analysis of the biosynthetic gene cluster of the lipopeptide antibiotic Friulimicin in Actinoplanes friuliensis.	Muller C, Nolden S, Gebhardt P, Heinzelmann E, Lange C, Puk O, Welzel K, Wohlleben W, Schwartz D.	Antimicrob Agents Chemother	10.1128/aac.00942-06	2007
Pathogenicity	The lipopeptide antibiotic Friulimicin B inhibits cell wall biosynthesis through complex formation with bactoprenol phosphate.	Schneider T, Gries K, Josten M, Wiedemann I, Pelzer S, Labischinski H, Sahl HG.	Antimicrob Agents Chemother	10.1128/aac.01040-08	2009
	Diverse and Abundant Secondary Metabolism Biosynthetic Gene Clusters in the Genomes of Marine Sponge Derived Streptomyces spp. Isolates.	Jackson SA, Crossman L, Almeida EL, Margassery LM, Kennedy J, Dobson ADW.	Mar Drugs	10.3390/md16020067	2018
Metabolism	Tuning the Mycobacterium tuberculosis Alternative Sigma Factor SigF through the Multidomain Regulator Rv1364c and Osmosensory Kinase Protein Kinase D.	Misra R, Menon D, Arora G, Virmani R, Gaur M, Naz S, Jaisinghani N, Bhaduri A, Bothra A, Maji A, Singhal A, Karwal P, Hentschker C, Becher D, Rao V, Nandicoori VK, Gandotra S, Singh Y.	J Bacteriol	10.1128/jb.00725-18	2019
Pathogenicity	Anti-infectious agents against MRSA.	Koyama N, Inokoshi J, Tomoda H.	Molecules	10.3390/molecules18010204	2012
Enzymology	Molecular cloning and identification of the laspartomycin biosynthetic gene cluster from Streptomyces viridochromogenes.	Wang Y, Chen Y, Shen Q, Yin X.	Gene	10.1016/j.gene.2011.05.005	2011
	A glutamate mutase is involved in the biosynthesis of the lipopeptide antibiotic friulimicin in Actinoplanes friuliensis.	Heinzelmann E, Berger S, Puk O, Reichenstein B, Wohlleben W, Schwartz D.	Antimicrob Agents Chemother	10.1128/aac.47.2.447-457.2003	2003
	Identification of Secondary Metabolite Gene Clusters in the Pseudovibrio Genus Reveals Encouraging Biosynthetic Potential toward the Production of Novel Bioactive Compounds.	Naughton LM, Romano S, O'Gara F, Dobson ADW.	Front Microbiol	10.3389/fmicb.2017.01494	2017
Pathogenicity	A liaR deletion restores susceptibility to daptomycin and antimicrobial peptides in multidrug-resistant Enterococcus faecalis.	Reyes J, Panesso D, Tran TT, Mishra NN, Cruz MR, Munita JM, Singh KV, Yeaman MR, Murray BE, Shamoo Y, Garsin D, Bayer AS, Arias CA.	J Infect Dis	10.1093/infdis/jiu602	2015
Metabolism	Selective overproduction of the proteasome inhibitor salinosporamide A via precursor pathway regulation.	Lechner A, Eustaquio AS, Gulder TA, Hafner M, Moore BS.	Chem Biol	10.1016/j.chembiol.2011.10.014	2011
Metabolism	Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.	Gomez C, Horna DH, Olano C, Palomino-Schatzlein M, Pineda-Lucena A, Carbajo RJ, Brana AF, Mendez C, Salas JA.	J Bacteriol	10.1128/jb.05062-11	2011
Metabolism	The complete genome sequence of the acarbose producer Actinoplanes sp. SE50/110.	Schwientek P, Szczepanowski R, Ruckert C, Kalinowski J, Klein A, Selber K, Wehmeier UF, Stoye J, Puhler A.	BMC Genomics	10.1186/1471-2164-13-112	2012
	Amidoligases with ATP-grasp, glutamine synthetase-like and acetyltransferase-like domains: synthesis of novel metabolites and peptide modifications of proteins.	Iyer LM, Abhiman S, Maxwell Burroughs A, Aravind L.	Mol Biosyst	10.1039/b917682a	2009
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Genetics	Complete genome sequence of the actinobacterium Actinoplanes friuliensis HAG 010964, producer of the lipopeptide antibiotic friulimycin.	Ruckert C, Szczepanowski R, Albersmeier A, Goesmann A, Fischer N, Steinkamper A, Puhler A, Biener R, Schwartz D, Kalinowski J	J Biotechnol	10.1016/j.jbiotec.2014.03.011	2014
	Purification and characterization of a novel lipopeptide from Streptomyces amritsarensis sp. nov. active against methicillin-resistant Staphylococcus aureus.	Sharma D, Mandal SM, Manhas RK.	AMB Express	10.1186/s13568-014-0050-y	2014
Phylogeny	Actinoplanes lichenis sp. nov., isolated from lichen.	Phongsopitanun W, Matsumoto A, Inahashi Y, Kudo T, Mori M, Shiomi K, Takahashi Y, Tanasupawat S	Int J Syst Evol Microbiol	10.1099/ijsem.0.000746	2015
Phylogeny	Emended description of Actinoplanes friuliensis and description of Actinoplanes nipponensis sp. nov., antibiotic-producing species of the genus Actinoplanes.	Wink J, Schumann P, Spoer C, Eisenbarth K, Glaeser SP, Martin K, Kampfer P	Int J Syst Evol Microbiol	10.1099/ijs.0.057836-0	2013
Phylogeny	Friulimicins: novel lipopeptide antibiotics with peptidoglycan synthesis inhibiting activity from Actinoplanes friuliensis sp. nov. II. Isolation and structural characterization.	Vertesy L, Ehlers E, Kogler H, Kurz M, Meiwes J, Seibert G, Vogel M, Hammann P	J Antibiot (Tokyo)	10.7164/antibiotics.53.816	2000
Metabolism	Friulimicins: novel lipopeptide antibiotics with peptidoglycan synthesis inhibiting activity from Actinoplanes friuliensis sp. nov. I. Taxonomic studies of the producing microorganism and fermentation.	Aretz W, Meiwes J, Seibert G, Vobis G, Wink J	J Antibiot (Tokyo)	10.7164/antibiotics.53.807	2000