Actinoplanes teichomyceticus (DSM 43866, ATCC 31121, BCRC 12106)

Cell morphology

Colony morphology

Multicellular morphology

Multimedia

• @ref:	11347
  multimedia content:	DSM_43866.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_43866.jpg
  caption:	Medium 252 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
11347	STARCH - MINERAL SALT - AGAR (STMS) (DSMZ Medium 252)		Medium recipe at MediaDive	Name: STARCH - MINERAL SALT - AGAR (STMS) (DSMZ Medium 252) Composition: Agar 14.985 g/l Starch 9.99001 g/l (NH4)2SO4 1.998 g/l CaCO3 1.998 g/l K2HPO4 0.999001 g/l MgSO4 x 7 H2O 0.999001 g/l NaCl 0.999001 g/l FeSO4 x 7 H2O 0.000999001 g/l MnCl2 x 4 H2O 0.000999001 g/l ZnSO4 x 7 H2O 0.000999001 g/l Distilled water
11347	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
19610	ISP 2			Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19610	ISP 3			Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19610	ISP 4			Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19610	ISP 5			Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19610	ISP 6			Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19610	ISP 7			Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes

Culture temp

Oxygen tolerance

Spore formation

Compound production

Halophily

Observation

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68368	29016 ChEBI	arginine	+	hydrolysis	from API 20E
68368	16947 ChEBI	citrate	-	assimilation	from API 20E
68368	5291 ChEBI	gelatin	+	hydrolysis	from API 20E
68368	25094 ChEBI	lysine	+	degradation	from API 20E
68368	18257 ChEBI	ornithine	+	degradation	from API 20E
68368	27897 ChEBI	tryptophan	-	energy source	from API 20E
68368	16199 ChEBI	urea	+	hydrolysis	from API 20E

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68368	15688 ChEBI	acetoin		from API 20E
68368	16136 ChEBI	hydrogen sulfide		from API 20E
68368	35581 ChEBI	indole		from API 20E

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Indole test
68368	15688 ChEBI	acetoin	+		from API 20E
68368	35581 ChEBI	indole		-	from API 20E

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68368	arginine dihydrolase	+	3.5.3.6	from API 20E
68382	beta-galactosidase	-	3.2.1.23	from API zym
68368	beta-galactosidase	-	3.2.1.23	from API 20E
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
68368	gelatinase	+		from API 20E
68382	leucine arylamidase	-	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68368	lysine decarboxylase	+	4.1.1.18	from API 20E
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
68368	ornithine decarboxylase	+	4.1.1.17	from API 20E
68382	trypsin	-	3.4.21.4	from API zym
68368	tryptophan deaminase	-	4.1.99.1	from API 20E
68368	urease	+	3.5.1.5	from API 20E
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	biotin biosynthesis	100	4 of 4
66794	octane oxidation	100	3 of 3
66794	sulfopterin metabolism	100	4 of 4
66794	coenzyme A metabolism	100	4 of 4
66794	formaldehyde oxidation	100	3 of 3
66794	valine metabolism	100	9 of 9
66794	glycogen metabolism	100	5 of 5
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	adipate degradation	100	2 of 2
66794	kanosamine biosynthesis II	100	2 of 2
66794	starch degradation	100	10 of 10
66794	ethanol fermentation	100	2 of 2
66794	threonine metabolism	100	10 of 10
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	ppGpp biosynthesis	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	cardiolipin biosynthesis	100	7 of 7
66794	denitrification	100	2 of 2
66794	methylglyoxal degradation	100	5 of 5
66794	folate polyglutamylation	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	aerobactin biosynthesis	100	1 of 1
66794	cellulose degradation	100	5 of 5
66794	ceramide biosynthesis	100	1 of 1
66794	tetrahydrofolate metabolism	92.86	13 of 14
66794	phenylalanine metabolism	92.31	12 of 13
66794	leucine metabolism	92.31	12 of 13
66794	pentose phosphate pathway	90.91	10 of 11
66794	NAD metabolism	88.89	16 of 18
66794	serine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	flavin biosynthesis	86.67	13 of 15
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	heme metabolism	85.71	12 of 14
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	glutathione metabolism	85.71	12 of 14
66794	photosynthesis	85.71	12 of 14
66794	vitamin B12 metabolism	85.29	29 of 34
66794	urea cycle	84.62	11 of 13
66794	purine metabolism	84.04	79 of 94
66794	1,4-dihydroxy-6-naphthoate biosynthesis	83.33	5 of 6
66794	glycolate and glyoxylate degradation	83.33	5 of 6
66794	selenocysteine biosynthesis	83.33	5 of 6
66794	glycolysis	82.35	14 of 17
66794	methionine metabolism	80.77	21 of 26
66794	glycine betaine biosynthesis	80	4 of 5
66794	hydrogen production	80	4 of 5
66794	Entner Doudoroff pathway	80	8 of 10
66794	vitamin K metabolism	80	4 of 5
66794	3-chlorocatechol degradation	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	tyrosine metabolism	78.57	11 of 14
66794	glutamate and glutamine metabolism	78.57	22 of 28
66794	citric acid cycle	78.57	11 of 14
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	4-hydroxymandelate degradation	77.78	7 of 9
66794	allantoin degradation	77.78	7 of 9
66794	lipid metabolism	77.42	24 of 31
66794	histidine metabolism	75.86	22 of 29
66794	alanine metabolism	75.86	22 of 29
66794	glycogen biosynthesis	75	3 of 4
66794	CMP-KDO biosynthesis	75	3 of 4
66794	gluconeogenesis	75	6 of 8
66794	dTDPLrhamnose biosynthesis	75	6 of 8
66794	acetate fermentation	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	ketogluconate metabolism	75	6 of 8
66794	oxidative phosphorylation	73.63	67 of 91
66794	metabolism of disaccharids	72.73	8 of 11
66794	cysteine metabolism	72.22	13 of 18
66794	aclacinomycin biosynthesis	71.43	5 of 7
66794	ubiquinone biosynthesis	71.43	5 of 7
66794	propanol degradation	71.43	5 of 7
66794	pyrimidine metabolism	71.11	32 of 45
66794	tryptophan metabolism	71.05	27 of 38
66794	myo-inositol biosynthesis	70	7 of 10
66794	4-hydroxyphenylacetate degradation	70	7 of 10
66794	vitamin B1 metabolism	69.23	9 of 13
66794	carotenoid biosynthesis	68.18	15 of 22
66794	IAA biosynthesis	66.67	2 of 3
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	d-mannose degradation	66.67	6 of 9
66794	acetoin degradation	66.67	2 of 3
66794	enterobactin biosynthesis	66.67	2 of 3
66794	non-pathway related	65.79	25 of 38
66794	isoprenoid biosynthesis	65.38	17 of 26
66794	polyamine pathway	65.22	15 of 23
66794	phenol degradation	65	13 of 20
66794	degradation of pentoses	64.29	18 of 28
66794	lysine metabolism	64.29	27 of 42
66794	d-xylose degradation	63.64	7 of 11
66794	degradation of sugar alcohols	62.5	10 of 16
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	3-phenylpropionate degradation	60	9 of 15
66794	propionate fermentation	60	6 of 10
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	lipoate biosynthesis	60	3 of 5
66794	gallate degradation	60	3 of 5
66794	elloramycin biosynthesis	60	3 of 5
66794	arginine metabolism	58.33	14 of 24
66794	androgen and estrogen metabolism	56.25	9 of 16
66794	degradation of sugar acids	56	14 of 25
66794	degradation of hexoses	55.56	10 of 18
66794	vitamin B6 metabolism	54.55	6 of 11
66794	proline metabolism	54.55	6 of 11
66794	coenzyme M biosynthesis	50	5 of 10
66794	ribulose monophosphate pathway	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	lactate fermentation	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	toluene degradation	50	2 of 4
66794	grixazone biosynthesis	50	1 of 2
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	quinate degradation	50	1 of 2
66794	bile acid biosynthesis, neutral pathway	47.06	8 of 17
66794	phosphatidylethanolamine bioynthesis	46.15	6 of 13
66794	sulfate reduction	46.15	6 of 13
66794	arachidonic acid metabolism	44.44	8 of 18
66794	lipid A biosynthesis	44.44	4 of 9
66794	nitrate assimilation	44.44	4 of 9
66794	daunorubicin biosynthesis	44.44	4 of 9
66794	ascorbate metabolism	40.91	9 of 22
66794	D-cycloserine biosynthesis	40	2 of 5
66794	ethylmalonyl-CoA pathway	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	glycine metabolism	40	4 of 10
66794	bacilysin biosynthesis	40	2 of 5
66794	carnitine metabolism	37.5	3 of 8
66794	sphingosine metabolism	33.33	2 of 6
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	chlorophyll metabolism	27.78	5 of 18
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	catecholamine biosynthesis	25	1 of 4
66794	vitamin E metabolism	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12
66794	alginate biosynthesis	25	1 of 4

API 20E

API zym

Isolation source categories

Isolation

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM371110v1 assembly for Actinoplanes teichomyceticus ATCC 31121	complete	GCA_003711105	457423.5	2856816149	457423	91.88
66792	Actinoplanes teichomyceticus DSM 43866	complete			651716759	1867	90.12
66792	ASM782991v1 assembly for Actinoplanes teichomyceticus DSM 43866	contig	GCA_007829915	1867.3	2818991480	1867	69.79
66792	ASM1686241v1 assembly for Actinoplanes teichomyceticus NBRC 13999	contig	GCA_016862415	1867.7	8117703225	1867	29.66

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Actinoplanes teichomyceticus gene for 16S rRNA, partial sequence	AB047513	1472		1867
20218	Actinoplanes teichomyceticus partial 16S rRNA gene, strain IMSNU 20043	AJ277584	1456		1867
11347	Actinoplanes teichomyceticus 16S rRNA gene, type strain DSM 43866T	AJ865472	1365		1867

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Draft Genome Sequence of Teicoplanin-Producing Strain Actinoplanes teichomyceticus CPCC 203265.	Li X, Zhang C, Lei X, Wang L, Hong B.	Microbiol Resour Announc	10.1128/mra.01091-19	2019
	Extending the Salinilactone Family.	Schlawis C, Harig T, Ehlers S, Guillen-Matus DG, Creamer KE, Jensen PR, Schulz S.	Chembiochem	10.1002/cbic.201900764	2020
Genetics	Metagenomic analysis of soybean endosphere microbiome to reveal signatures of microbes for health and disease.	Chouhan U, Gamad U, Choudhari JK.	J Genet Eng Biotechnol	10.1186/s43141-023-00535-4	2023
	A proof-reading mechanism for non-proteinogenic amino acid incorporation into glycopeptide antibiotics.	Kaniusaite M, Tailhades J, Marschall EA, Goode RJA, Schittenhelm RB, Cryle MJ.	Chem Sci	10.1039/c9sc03678d	2019
Genetics	A Genomics-Based Discovery of Secondary Metabolite Biosynthetic Gene Clusters in the Potential Novel Strain Streptomyces sp. 21So2-11 Isolated from Antarctic Soil	Du Y, Han W, Hao P, Hu Y, Hu T, Zeng Y.	Microorganisms		2024
Genetics	Complete Genome Assembly of Amycolatopsis bartoniae DSM 45807T Allows the Characterization of a Novel Glycopeptide Biosynthetic Gene Cluster.	Stepanyshyn A, Ruckert-Reed C, Busche T, Yaruta B, Andreo-Vidal A, Marinelli F, Kalinowski J, Yushchuk O.	Genes (Basel)	10.3390/genes15121651	2024
	Cross-Talking of Pathway-Specific Regulators in Glycopeptide Antibiotics (Teicoplanin and A40926) Production.	Andreo-Vidal A, Yushchuk O, Marinelli F, Binda E.	Antibiotics (Basel)	10.3390/antibiotics12040641	2023
	Specificity of Induction of Glycopeptide Antibiotic Resistance in the Producing Actinomycetes.	Binda E, Cappelletti P, Marinelli F, Marcone GL.	Antibiotics (Basel)	10.3390/antibiotics7020036	2018
	A rare peptide scaffold in kineomicins, the glycopeptide antibiotics produced by Actinokineospora auranticolor DSM 44650.	Yushchuk O, Berini F, Zhong L, Ruckert-Reed C, Bernasconi E, Bartolone L, Busche T, Kalinowski J, Sussmuth RD, Marinelli F.	Commun Chem	10.1038/s42004-025-01534-x	2025
	Genetics Behind the Glycosylation Patterns in the Biosynthesis of Dalbaheptides.	Yushchuk O, Zhukrovska K, Berini F, Fedorenko V, Marinelli F.	Front Chem	10.3389/fchem.2022.858708	2022
Metabolism	Microbial transformation of 2-amino-4-methyl-3-nitropyridine.	Tully T, Liu M, Huang Y, Ye Q, Patel RN, Goswami A.	J Ind Microbiol Biotechnol	10.1007/s10295-012-1189-7	2012
Pathogenicity	Relationship between glycopeptide production and resistance in the actinomycete Nonomuraea sp. ATCC 39727.	Marcone GL, Binda E, Carrano L, Bibb M, Marinelli F.	Antimicrob Agents Chemother	10.1128/aac.02626-14	2014
Enzymology	Granulomatous amebic encephalitis in a child with acute lymphoblastic leukemia successfully treated with multimodal antimicrobial therapy and hyperbaric oxygen.	Maritschnegg P, Sovinz P, Lackner H, Benesch M, Nebl A, Schwinger W, Walochnik J, Urban C.	J Clin Microbiol	10.1128/jcm.01456-10	2011
Metabolism	Overproduction of Ristomycin A by activation of a silent gene cluster in Amycolatopsis japonicum MG417-CF17.	Spohn M, Kirchner N, Kulik A, Jochim A, Wolf F, Muenzer P, Borst O, Gross H, Wohlleben W, Stegmann E.	Antimicrob Agents Chemother	10.1128/aac.03512-14	2014
	DNA in antibiotic preparations: absence of intact resistance genes.	Woegerbauer M, Lagler H, Graninger W, Burgmann H.	Antimicrob Agents Chemother	10.1128/aac.49.6.2490-2494.2005	2005
	Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within the Actinobacteria Phylum.	Andreo-Vidal A, Binda E, Fedorenko V, Marinelli F, Yushchuk O.	Antibiotics (Basel)	10.3390/antibiotics10121533	2021
Pathogenicity	Novel mechanism of glycopeptide resistance in the A40926 producer Nonomuraea sp. ATCC 39727.	Marcone GL, Beltrametti F, Binda E, Carrano L, Foulston L, Hesketh A, Bibb M, Marinelli F.	Antimicrob Agents Chemother	10.1128/aac.00106-10	2010
Metabolism	Essentiality of the Maltase AmlE in Maltose Utilization and Its Transcriptional Regulation by the Repressor AmlR in the Acarbose-Producing Bacterium Actinoplanes sp. SE50/110.	Schaffert L, Schneiker-Bekel S, Dymek S, Droste J, Persicke M, Busche T, Brandt D, Puhler A, Kalinowski J.	Front Microbiol	10.3389/fmicb.2019.02448	2019
Pathogenicity	Comparison of the in vitro activities of teichomycin A2 and vancomycin against staphylococci and enterococci.	Cynamon MH, Granato PA.	Antimicrob Agents Chemother	10.1128/aac.21.3.504	1982
Metabolism	Use of direct-infusion electrospray mass spectrometry to guide empirical development of improved conditions for expression of secondary metabolites from actinomycetes.	Zahn JA, Higgs RE, Hilton MD.	Appl Environ Microbiol	10.1128/aem.67.1.377-386.2001	2001
Metabolism	Charge and lipophilicity govern the pharmacokinetics of glycopeptide antibiotics.	Pitkin DH, Mico BA, Sitrin RD, Nisbet LJ.	Antimicrob Agents Chemother	10.1128/aac.29.3.440	1986
	In vitro activity and human pharmacokinetics of teicoplanin.	Verbist L, Tjandramaga B, Hendrickx B, Van Hecken A, Van Melle P, Verbesselt R, Verhaegen J, De Schepper PJ.	Antimicrob Agents Chemother	10.1128/aac.26.6.881	1984
	The Impact of Heterologous Regulatory Genes from Lipodepsipeptide Biosynthetic Gene Clusters on the Production of Teicoplanin and A40926.	Zhukrovska K, Binda E, Fedorenko V, Marinelli F, Yushchuk O.	Antibiotics (Basel)	10.3390/antibiotics13020115	2024
Biotechnology	Strain Improvement and Strain Maintenance Revisited. The Use of Actinoplanes teichomyceticus ATCC 31121 Protoplasts in the Identification of Candidates for Enhanced Teicoplanin Production.	Mellere L, Bava A, Capozzoli C, Branduardi P, Berini F, Beltrametti F	Antibiotics (Basel)	10.3390/antibiotics11010024	2021
Metabolism	Microparticles enhance the formation of seven major classes of natural products in native and metabolically engineered actinobacteria through accelerated morphological development.	Kuhl M, Ruckert C, Glaser L, Beganovic S, Luzhetskyy A, Kalinowski J, Wittmann C	Biotechnol Bioeng	10.1002/bit.27818	2021
Genetics	Genetic insights into the mechanism of teicoplanin self-resistance in Actinoplanes teichomyceticus.	Yushchuk O, Homoniuk V, Ostash B, Marinelli F, Fedorenko V	J Antibiot (Tokyo)	10.1038/s41429-019-0274-9	2020
Enzymology	Cloning of metK from Actinoplanes teichomyceticus ATCC31121 and effect of its high expression on antibiotic production.	Kim DY, Hwang YI, Choi SU	J Microbiol Biotechnol	10.4014/jmb.1101.01018	2011
Metabolism	Actinoplanes teichomyceticus ATCC 31121 as a cell factory for producing teicoplanin.	Taurino C, Frattini L, Marcone GL, Gastaldo L, Marinelli F	Microb Cell Fact	10.1186/1475-2859-10-82	2011
Metabolism	Protoplast preparation and reversion to the normal filamentous growth in antibiotic-producing uncommon actinomycetes.	Marcone GL, Carrano L, Marinelli F, Beltrametti F	J Antibiot (Tokyo)	10.1038/ja.2009.127	2010
Metabolism	Biotransformations of lipoglycopeptides to obtain novel antibiotics.	Gandolfi R, Jovetic S, Marinelli F, Molinari F	J Antibiot (Tokyo)	10.1038/ja.2007.33	2007
Metabolism	Resistance to glycopeptide antibiotics in the teicoplanin producer is mediated by van gene homologue expression directing the synthesis of a modified cell wall peptidoglycan.	Beltrametti F, Consolandi A, Carrano L, Bagatin F, Rossi R, Leoni L, Zennaro E, Selva E, Marinelli F	Antimicrob Agents Chemother	10.1128/AAC.01071-06	2007
Pathogenicity	Synthesis and antibacterial activity of alkyl derivatives of the glycopeptide antibiotic A40926 and their amides.	Maffioli SI, Ciabatti R, Romano G, Marzorati E, Preobrazhenskaya M, Pavlov A	Bioorg Med Chem Lett	10.1016/j.bmcl.2005.05.076	2005
Metabolism	Biosynthetic studies of the glycopeptide teicoplanin by (1)H and (13)C NMR.	Heydorn A, Petersen BO, Duus JO, Bergmann S, Suhr-Jessen T, Nielsen J	J Biol Chem	10.1074/jbc.275.9.6201	2000
Enzymology	Growth and production kinetics of a teicoplanin producing strain of Actinoplanes teichomyceticus.	Heydorn A, Suhr-Jessen T, Nielsen J	J Antibiot (Tokyo)	10.7164/antibiotics.52.40	1999
Metabolism	Microbial de-mannosylation and mannosylation of teicoplanin derivatives.	Borghi A, Ferrari P, Gallo GG, Zanol M, Zerilli LF, Lancini GC	J Antibiot (Tokyo)	10.7164/antibiotics.44.1444	1991
Metabolism	Teichomycins, new antibiotics from Actinoplanes teichomyceticus Nov. Sp. I. Description of the producer strain, fermentation studies and biological properties.	Parenti F, Beretta G, Berti M, Arioli V	J Antibiot (Tokyo)	10.7164/antibiotics.31.276	1978
Phylogeny	Actinoplanes liguriensis sp. nov. and Actinoplanes teichomyceticus sp. nov.	Wink JM, Kroppenstedt RM, Schumann P, Seibert G, Stackebrandt E	Int J Syst Evol Microbiol	10.1099/ijs.0.64240-0	2006