Bacillus coagulans (DSM 1, CCM 2013, NCIB 9365)

Name: Bacillus coagulans (DSM 1, CCM 2013, NCIB 9365)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 654

Type strain

Strain Designation 609, NRS-609

Culture col. no. DSM 1 CCM 2013 NCIB 9365 NCTC 10334 WDCM 00002 27 more

NCBI tax ID(s) 1121088 1398

Special Collections DSMZ CCUG JCM KCTC CIP Literature strains

History <- ATCC <- N.R. Smith, 609 <- J. Porter <- B. Hammer IAM 1115 <-- ATCC 7050 <-- N. R. Smith 609 <-- J. R. Porter <-- B. W. Hammer. CIP <- 1966, ATCC <- N.R. Smith: strain NRS-609 <- 1937, J. Porter <- B. Hammer

Links

Bacillus coagulans 609 is an aerobe bacterium that produces lactate and was isolated from evaporated milk.

lactate production aerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 92137

LMG 6326,ATCC 7050,CCM 2013,CCUG 7417,CECT 12,DSM 1,IAM 1115,IAM 12463,IFO 12583,JCM 2257,LMG 17450,LMG 17455,NCFB 1761,NCIB 9365,NCTC 10334,NRRL NRS-609,NBIMCC 8941,PCM 1843,NCDO 1761,CCRC 10606,IMET 10993,NCIMB 9365,VKM B-731,VKM B-497,LMD 48.14,LMD 77.25,NCAIM B.01086,VTT E-82150,KCTC 3625,NBRC 12583,NCCB 77025,NCCB 48014,BCRC 10606,CFBP 4225,HAMBI 1931,CCT 0199,CCT 2467,KACC 11248,NBIMCC 1511,CNCTC 5646,CGMCC 1.2009,VTT E-98150,CIP 66.25

@ref 20215

Last LPSN update 2026-02-09 11:17:55

Domain Bacteria

Phylum Bacillota

Class Bacilli

Order Caryophanales

Family Bacillaceae

Genus Bacillus

Species Bacillus coagulans

Full scientific name Bacillus coagulans Hammer 1915 (Approved Lists 1980)

Synonyms (2)

Heyndrickxia coagulans
Weizmannia coagulans

BacDive ID	Other strains from **Bacillus coagulans** (9)	Type strain
100137	B. coagulans STI09070(IMET), 1032-005,
100138	B. coagulans STI09076(IMET), 1141-003,
100139	B. coagulans STI09080(IMET), 1136-014,
100140	B. coagulans STI09210(IMET), 485-59,
100141	B. coagulans STI09208(IMET), 491-25,
136030	B. coagulans 963.85, CIP 102020
137618	B. coagulans CIP 51.34, CN 2821
140654	B. coagulans 36D1, ATCC 5827
147772	B. coagulans CCUG 34203

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Cell length
22893				5.5-6 µm
118318	positive	rod-shaped

Colony morphology

@ref	Colony color
22893	white
118318

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
41798	MEDIUM 3 - Columbia agar		Columbia agar (39.000 g);distilled water (1000.000 ml)
2009	NUTRIENT AGAR (DSMZ Medium 1)	Medium recipe at MediaDive	Name: NUTRIENT AGAR (DSMZ Medium 1) Composition: Agar 15.0 g/l Peptone 5.0 g/l Meat extract 3.0 g/l Distilled water
2009	STANDARD I MEDIUM (DSMZ Medium 453)	Medium recipe at MediaDive	Name: STANDARD I MEDIUM (DSMZ Medium 453) Composition: Casein peptone 7.8 g/l Meat peptone 7.8 g/l NaCl 5.6 g/l Yeast extract 2.8 g/l D(+)-Glucose 1.0 g/l Distilled water
118318	CIP Medium 72	Medium recipe at CIP
118318	CIP Medium 3	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
2009	positive	growth	40
22893	positive	growth	30-55
22894	positive	maximum	60
41798	positive	growth	37
44986	positive	growth	37
67770	positive	growth	37
118318	positive	growth	22-55
118318	negative	growth	10

Culture pH

@ref	Ability	Type	PH
118318	positive	growth	6

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
44986	aerobe
44986	anaerobe
118318	facultative anaerobe

Spore formation

@ref	Spore formation	Confidence
125438		90.115

Compound production

@ref	Compound
2009	inhibitors for glycoside hydrolases
2009	L(+) lactic acid
2009	oligo-1,6 glucosidase
22893	Lactic acid
22893	Acetoin
22894	Acetoin
20216	Inhibitors for glycoside hydrolases

Halophily

@ref	Salt	Growth	Tested relation	Concentration
118318	NaCl	positive	growth	0-6 %
118318	NaCl		growth	8 %
118318	NaCl		growth	10 %

Observation

67770

Observationquinones: MK-7

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
22894	16808 ChEBI	2-dehydro-D-gluconate	-	growth
22894	58143 ChEBI	5-dehydro-D-gluconate	-	growth
22894		casein	-	hydrolysis
22894	16947 ChEBI	citrate	-	growth
118318	16947 ChEBI	citrate	-	carbon source
22894	15824 ChEBI	D-fructose	+	growth
22894	28847 ChEBI	D-fucose	-	growth
22894	12936 ChEBI	D-galactose	+	growth
22894	12936 ChEBI	D-galactose	+	fermentation
22894	17634 ChEBI	D-glucose	+	growth
22893	62318 ChEBI	D-lyxose	-	builds acid from
22894	62318 ChEBI	D-lyxose	-	growth
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
22894	16024 ChEBI	D-mannose	+	growth
22894	16024 ChEBI	D-mannose	+	fermentation
68379	16988 ChEBI	D-ribose	-	fermentation	from API Coryne
22893	16443 ChEBI	D-tagatose	-	builds acid from
22894	16443 ChEBI	D-tagatose	-	growth
22893	65327 ChEBI	D-xylose	-	builds acid from
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
22893	4853 ChEBI	esculin	+	builds acid from
68379	4853 ChEBI	esculin	-	hydrolysis	from API Coryne
118318	4853 ChEBI	esculin	+	hydrolysis
22893	28757 ChEBI	fructose	+	builds acid from
22894	16813 ChEBI	galactitol	-	growth
22893	28260 ChEBI	galactose	+	builds acid from
22893	5291 ChEBI	gelatin	-	hydrolysis
22894	5291 ChEBI	gelatin	-	hydrolysis
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
22893	24265 ChEBI	gluconate	+	builds acid from
22893	17234 ChEBI	glucose	+	builds acid from
22893	17234 ChEBI	glucose	+	fermentation
22893	17754 ChEBI	glycerol	+	builds acid from
22894	17754 ChEBI	glycerol	+	growth
22894	28087 ChEBI	glycogen	-	growth
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
118318	606565 ChEBI	hippurate	-	hydrolysis
22894	15443 ChEBI	inulin	-	growth
22893	30849 ChEBI	L-arabinose	-	builds acid from
22894	18403 ChEBI	L-arabitol	-	growth
22894	18287 ChEBI	L-fucose	-	growth
22894	17266 ChEBI	L-sorbose	-	growth
22894	65328 ChEBI	L-xylose	-	growth
22893	17716 ChEBI	lactose	+	builds acid from
22894	17716 ChEBI	lactose	+	fermentation
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
22894	17306 ChEBI	maltose	+	growth
22894	17306 ChEBI	maltose	+	fermentation
68379	17306 ChEBI	maltose	+	fermentation	from API Coryne
22893	29864 ChEBI	mannitol	-	builds acid from
22894	29864 ChEBI	mannitol	-	growth
22893	37684 ChEBI	mannose	+	builds acid from
22894	6731 ChEBI	melezitose	-	growth
22894	28053 ChEBI	melibiose	+	growth
22894	28053 ChEBI	melibiose	+	fermentation
22894	43943 ChEBI	methyl alpha-D-mannoside	-	growth
22894	74863 ChEBI	methyl beta-D-xylopyranoside	-	growth
22893	37657 ChEBI	methyl D-glucoside	-	builds acid from
22893	506227 ChEBI	N-acetyl-D-glucosamine	+	builds acid from
22894	506227 ChEBI	N-acetyl-D-glucosamine	+	growth
22894	17632 ChEBI	nitrate	-	reduction
68379	17632 ChEBI	nitrate	-	reduction	from API Coryne
118318	17632 ChEBI	nitrate	-	reduction
118318	17632 ChEBI	nitrate	+	respiration
118318	16301 ChEBI	nitrite	-	reduction
22894	17272 ChEBI	propionate	-	growth
22893	26546 ChEBI	rhamnose	-	builds acid from
22894	15963 ChEBI	ribitol	-	growth
22893	33942 ChEBI	ribose	-	builds acid from
22893	17814 ChEBI	salicin	+/-	builds acid from
22893	28017 ChEBI	starch	+/-	builds acid from
22894	28017 ChEBI	starch	+	hydrolysis
22894	28017 ChEBI	starch	+	fermentation
22893	17992 ChEBI	sucrose	-	builds acid from
22894	17992 ChEBI	sucrose	+	fermentation
68379	17992 ChEBI	sucrose	+	fermentation	from API Coryne
22893	27082 ChEBI	trehalose	+	builds acid from
22894	27082 ChEBI	trehalose	+	growth
22893	32528 ChEBI	turanose	+	builds acid from
68379	16199 ChEBI	urea	-	hydrolysis	from API Coryne
22894	17151 ChEBI	xylitol	-	growth

Metabolite production

@ref	Chebi-ID	Metabolite
22893	15688 ChEBI	acetoin
22894	15688 ChEBI	acetoin
22894	16136 ChEBI	hydrogen sulfide
22894	35581 ChEBI	indole
118318	35581 ChEBI	indole
22893	24996 ChEBI	lactate

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
22893	15688 ChEBI	acetoin	+
22894	15688 ChEBI	acetoin	+
118318	15688 ChEBI	acetoin	+
22893	17234 ChEBI	glucose		+
118318	17234 ChEBI	glucose		+

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
118318	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68379	alkaline phosphatase	-	3.1.3.1	from API Coryne
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68379	alpha-glucosidase	-	3.2.1.20	from API Coryne
68382	alpha-mannosidase	-	3.2.1.24	from API zym
118318	amylase	-
22894	arginine dihydrolase	-	3.5.3.6
22893	beta-galactosidase	+	3.2.1.23
68382	beta-galactosidase	+	3.2.1.23	from API zym
118318	beta-galactosidase	+	3.2.1.23
68379	beta-galactosidase	+	3.2.1.23	from API Coryne
68382	beta-glucosidase	-	3.2.1.21	from API zym
68379	beta-glucosidase	-	3.2.1.21	from API Coryne
68382	beta-glucuronidase	+	3.2.1.31	from API zym
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
118318	caseinase	+	3.4.21.50
118318	catalase	+	1.11.1.6
68379	catalase	+	1.11.1.6	from API Coryne
68382	cystine arylamidase	-	3.4.11.3	from API zym
118318	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
118318	gamma-glutamyltransferase	-	2.3.2.2
22893	gelatinase	-
22894	gelatinase	-
118318	gelatinase	-
68379	gelatinase	-		from API Coryne
118318	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
118318	lipase	-
68382	lipase (C 14)	-		from API zym
22894	lysine decarboxylase	-	4.1.1.18
118318	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68379	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API Coryne
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
22894	ornithine decarboxylase	-	4.1.1.17
118318	ornithine decarboxylase	-	4.1.1.17
118318	oxidase	-
68379	pyrazinamidase	+	3.5.1.B15	from API Coryne
68379	pyrrolidonyl arylamidase	-	3.4.19.3	from API Coryne
68382	trypsin	-	3.4.21.4	from API zym
22894	tryptophan deaminase	-	4.1.99.1
118318	tween esterase	+
22894	urease	-	3.5.1.5
118318	urease	-	3.5.1.5
68379	urease	-	3.5.1.5	from API Coryne
68382	valine arylamidase	-		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
44986	-	+	-	-	-	+	-	-	-	-	-	-	not determinedn.d.	-	-	-	+	-	+	-	+

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
118318	-	+	+	+	-	+	-	-	-	-	+	+	+	+	+	+	-	-	-	-

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
118318	not determinedn.d.	-	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Engineered	#Food production	#Dairy product

Isolation

@ref	Sample type
2009	evaporated milk
44986	Milk,evaporated
67770	Evaporated milk
118318	Food, Milk powder

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Biosafety level	Biosafety level comment
2009	yes, in single cases	1	Risk group (German classification) According to TRBA 466
118318		1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM83290v1 assembly for Heyndrickxia coagulans DSM 1 = ATCC 7050	complete	GCA_000832905	1121088.10	2630968645	1121088	97.54
67770	IMG-taxon 2582581263 annotated assembly for Heyndrickxia coagulans DSM 1 = ATCC 7050	scaffold	GCA_900128875	1121088.13	2582581263	1121088	48.51
67770	ASM42020v1 assembly for Heyndrickxia coagulans DSM 1 = ATCC 7050	contig	GCA_000420205	1121088.9	2524614861	1121088	43.83
124043	ASM3131671v1 assembly for Heyndrickxia coagulans DSM 1 = ATCC 7050	contig	GCA_031316715	1121088.44	8118935624	1121088	16.61
67770	ASM29061v1 assembly for Heyndrickxia coagulans DSM 1 = ATCC 7050	contig	GCA_000290615	1121088.3	2551306088	1121088	16.31

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
2009	Bacillus coagulans strain ATCC 7050 16S ribosomal RNA gene, partial sequence	DQ297928	1549	1121088
67770	Bacillus coagulans gene for 16S rRNA, partial sequence	AB271752	1479	1398
67770	Bacillus coagulans gene for 16S rRNA, partial sequence, strain: IAM 12463	D16267	1481	1398
67770	B.coagulans 16S ribosomal RNA	X60614	1429	1398
124043	Bacillus coagulans gene for 16S rRNA, partial sequence.	AB006924	277	1398
124043	Bacillus coagulans strain JCM2257 DNA for 16S ribosomal RNA, partial sequence.	D78313	1422	1398
124043	Bacillus coagulans strain NBRC-12583 16S ribosomal RNA gene, partial sequence.	KX261624	1285	1398

GC content

@ref	GC-content (mol%)	Method
2009	47.1	thermal denaturation, midpoint method (Tm)
2009	44.5	Buoyant density centrifugation (BD)
67770	46.6	thermal denaturation, midpoint method (Tm)
67770	44.9	Buoyant density centrifugation (BD)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Bacillus coagulans DSM 1 = ATCC 7050
PATRIC: 1121088.10

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	63.90	no
125439	gram_stain	BacteriaNetⓘ	variable	87.20	no
125439	motility	BacteriaNetⓘ	yes	65.20	no
125439	spore_formation	BacteriaNetⓘ	yes	75.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Weizmannia coagulans DSM 1 = ATCC 7050 ATCC 7050
NCBI: GCA_000832905.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	79.71	no
125438	anaerobic	anaerobicⓘ	no	86.88	no
125438	aerobic	aerobicⓘ	yes	59.25	no
125438	spore-forming	spore-formingⓘ	yes	90.12	no
125438	thermophilic	thermophileⓘ	no	82.10	yes
125438	flagellated	motile2+ⓘ	yes	78.09	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Targeted Assay Engineering Enhances Bile Salt Hydrolase Activity in Heyndrickxia coagulans ATCC 7050 and Lactiplantibacillus plantarum ATCC 10012.	Nair PP, Annapure US.	Curr Microbiol	10.1007/s00284-024-04028-6	2025
Cultivation	Fermentation dynamics of bile salt hydrolase production in Heyndrickxia coagulans ATCC 7050 and Lactiplantibacillus plantarum ATCC 10012: Addressing ninhydrin assay limitations with a novel HPTLC-MS method.	Nair PP, Annapure US.	J Microbiol Methods	10.1016/j.mimet.2024.107050	2024
	Characterization of a newly isolated biosurfactant fengycin produced by Heyndrickxia coagulans strain.	Stykova E, Bedlovicova Z, Surin Hudakova N, Karaffova V, Kalocsaiova K, Bhide M.	AMB Express	10.1186/s13568-025-01942-1	2025
	Comprehensive genomic analysis and evaluation of in vivo and in vitro safety of Heyndrickxia coagulans BC99.	Wu Y, Wu Z, Gao Y, Fan Y, Dong Y, Zhang Y, Gai Z, Gu S.	Sci Rep	10.1038/s41598-024-78202-y	2024
Biotechnology	Complete genome sequence of Heyndrickxia (Bacillus) coagulans BC99 isolated from a fecal sample of a healthy infant.	Zhu M, Zhu J, Fang S, Zhao B.	Microbiol Resour Announc	10.1128/mra.00449-23	2024
	Characterisation of Enterocins Produced by Antilisterial Enterococcus faeciumBH04, BH12, BH84, and BH99 and In Vitro/In Situ Inhibition of Listeria monocytogenes.	Aktas H.	Food Sci Nutr	10.1002/fsn3.70142	2025
	Effects of Bacillus coagulans (GBI-30, 6086) Supplementation on the Fecal Characteristics and Microbiota of Healthy Adult Dogs Subjected to an Abrupt Diet Change.	Wilson SM, Kang Y, Wren JF, Menton JF, Vinay E, Millette M, Kelly MR, Swanson KS.	Microorganisms	10.3390/microorganisms13112462	2025
	The Potential of Bacillus Species as Probiotics in the Food Industry: A Review.	Payne J, Bellmer D, Jadeja R, Muriana P.	Foods	10.3390/foods13152444	2024
Pathogenicity	A Rapid Screening Method of Candidate Probiotics for Inflammatory Bowel Diseases and the Anti-inflammatory Effect of the Selected Strain Bacillus smithii XY1.	Huang X, Ai F, Ji C, Tu P, Gao Y, Wu Y, Yan F, Yu T	Front Microbiol	10.3389/fmicb.2021.760385	2021
Enzymology	Development and validation of a predictive model for the effect of temperature, pH and water activity on the growth kinetics of Bacillus coagulans in non-refrigerated ready-to-eat food products.	Misiou O, Zourou C, Koutsoumanis K	Food Res Int	10.1016/j.foodres.2021.110705	2021
Biotechnology	Third-generation L-Lactic acid production by the microwave-assisted hydrolysis of red macroalgae Eucheuma denticulatum extract.	Tong KTX, Tan IS, Foo HCY, Tiong ACY, Lam MK, Lee KT	Bioresour Technol	10.1016/j.biortech.2021.125880	2021
Biotechnology	Rapid detection and discrimination of food-related bacteria using IR-microspectroscopy in combination with multivariate statistical analysis.	Klein D, Breuch R, Reinmuller J, Engelhard C, Kaul P	Talanta	10.1016/j.talanta.2021.122424	2021
Biotechnology	[Expression and characterization of beta-N-acetylglucosaminidases from Bacillus coagulans DSM1 for N-acetyl-beta-D glucosamine production].	Li C, Jiang S, Du C, Zhou Y, Jiang S, Zhang G	Sheng Wu Gong Cheng Xue Bao	10.13345/j.cjb.200190	2021
	Effect of Physical and Chemical Treatments on Viability, Sub-Lethal Injury, and Release of Cellular Components from Bacillus clausii and Bacillus coagulans Spores and Cells.	Bevilacqua A, Petruzzi L, Sinigaglia M, Speranza B, Campaniello D, Ciuffreda E, Corbo MR	Foods	10.3390/foods9121814	2020
Genetics	Genome based safety assessment for Bacillus coagulans strain LBSC (DSM 17654) for probiotic application.	Saroj DB, Gupta AK	Int J Food Microbiol	10.1016/j.ijfoodmicro.2020.108523	2020
Metabolism	Elucidating the Role and Regulation of a Lactate Permease as Lactate Transporter in Bacillus coagulans DSM1.	Wang Y, Zhang C, Liu G, Ju J, Yu B, Wang L	Appl Environ Microbiol	10.1128/AEM.00672-19	2019
Pathogenicity	Dietary supplementation of probiotic Bacillus coagulans ATCC 7050, improves the growth performance, intestinal morphology, microflora, immune response, and disease confrontation of Pacific white shrimp, Litopenaeus vannamei.	Amoah K, Huang QC, Tan BP, Zhang S, Chi SY, Yang QH, Liu HY, Dong XH	Fish Shellfish Immunol	10.1016/j.fsi.2019.02.029	2019
	Simultaneous consumption of cellobiose and xylose by Bacillus coagulans to circumvent glucose repression and identification of its cellobiose-assimilating operons.	Zheng Z, Jiang T, Zou L, Ouyang S, Zhou J, Lin X, He Q, Wang L, Yu B, Xu H, Ouyang J	Biotechnol Biofuels	10.1186/s13068-018-1323-5	2018
	Non-sterilized fermentation of high optically pure D-lactic acid by a genetically modified thermophilic Bacillus coagulans strain.	Zhang C, Zhou C, Assavasirijinda N, Yu B, Wang L, Ma Y	Microb Cell Fact	10.1186/s12934-017-0827-1	2017
Metabolism	Contributory roles of two l-lactate dehydrogenases for l-lactic acid production in thermotolerant Bacillus coagulans.	Sun L, Zhang C, Lyu P, Wang Y, Wang L, Yu B	Sci Rep	10.1038/srep37916	2016
Cultivation	Systematic development and optimization of chemically defined medium supporting high cell density growth of Bacillus coagulans.	Chen Y, Dong F, Wang Y	Appl Microbiol Biotechnol	10.1007/s00253-016-7644-z	2016
Metabolism	Hemp hurds biorefining: A path to green L-(+)-lactic acid production.	Gandolfi S, Pistone L, Ottolina G, Xu P, Riva S	Bioresour Technol	10.1016/j.biortech.2015.04.118	2015
Enzymology	Purification and characterization of a novel plantaricin, KL-1Y, from Lactobacillus plantarum KL-1.	Rumjuankiat K, Perez RH, Pilasombut K, Keawsompong S, Zendo T, Sonomoto K, Nitisinprasert S	World J Microbiol Biotechnol	10.1007/s11274-015-1851-0	2015
Pathogenicity	Open fermentative production of L-lactic acid with high optical purity by thermophilic Bacillus coagulans using excess sludge as nutrient.	Ma K, Maeda T, You H, Shirai Y	Bioresour Technol	10.1016/j.biortech.2013.10.022	2013
Pathogenicity	Mode of action and safety of lactosporin, a novel antimicrobial protein produced by Bacillus coagulans ATCC 7050.	Riazi S, Dover SE, Chikindas ML	J Appl Microbiol	10.1111/j.1365-2672.2012.05376.x	2012
Enzymology	Characterization of lactosporin, a novel antimicrobial protein produced by Bacillus coagulans ATCC 7050.	Riazi S, Wirawan RE, Badmaev V, Chikindas ML	J Appl Microbiol	10.1111/j.1365-2672.2008.04105.x	2009
Phylogeny	Characterization, N-terminal sequencing and classification of cerein MRX1, a novel bacteriocin purified from a newly isolated bacterium: Bacillus cereus MRX1.	Sebei S, Zendo T, Boudabous A, Nakayama J, Sonomoto K	J Appl Microbiol	10.1111/j.1365-2672.2007.03395.x	2007
Metabolism	Biosorption of Cr(VI) by three different bacterial species supported on granular activated carbon: a comparative study.	Quintelas C, Fernandes B, Castro J, Figueiredo H, Tavares T	J Hazard Mater	10.1016/j.jhazmat.2007.09.027	2007
Phylogeny	Open L-lactic acid fermentation of food refuse using thermophilic Bacillus coagulans and fluorescence in situ hybridization analysis of microflora.	Sakai K, Ezaki Y	J Biosci Bioeng	10.1263/jbb.101.457	2006
Biotechnology	Application of the broad-spectrum bacteriocin enterocin AS-48 to inhibit Bacillus coagulans in canned fruit and vegetable foods.	Lucas R, Grande MA, Abriouel H, Maqueda M, Ben Omar N, Valdivia E, Martinez-Canamero M, Galvez A	Food Chem Toxicol	10.1016/j.fct.2006.05.019	2006
Phylogeny	Isolation and characterization of acid-tolerant, thermophilic bacteria for effective fermentation of biomass-derived sugars to lactic acid.	Patel MA, Ou MS, Harbrucker R, Aldrich HC, Buszko ML, Ingram LO, Shanmugam KT	Appl Environ Microbiol	10.1128/AEM.72.5.3228-3235.2006	2006
Cultivation	[Inhibition of Bacillus coagulans growth in laboratory media and in fruit purees].	Cerrutti P, Alzamora SM, de Huergo MS	Rev Argent Microbiol		2000
Enzymology	Clustered proline residues around the active-site cleft in thermostable oligo-1,6-glucosidase of Bacillus flavocaldarius KP1228.	Kashiwabara S, Matsuki Y, Kishimoto T, Suzuki Y	Biosci Biotechnol Biochem	10.1271/bbb.62.1093	1998
Enzymology	Analysis of the critical sites for protein thermostabilization by proline substitution in oligo-1,6-glucosidase from Bacillus coagulans ATCC 7050 and the evolutionary consideration of proline residues.	Watanabe K, Kitamura K, Suzuki Y	Appl Environ Microbiol	10.1128/aem.62.6.2066-2073.1996	1996
Enzymology	Purification and characterization of Bacillus coagulans oligo-1,6-glucosidase.	Suzuki Y, Tomura Y	Eur J Biochem	10.1111/j.1432-1033.1986.tb09723.x	1986
Enzymology	Purification and properties of the D-alanyl-D-alanine carboxypeptidase of Bacillus coagulans NCIB 9365.	McArthur HA, Reynolds PE	Biochim Biophys Acta	10.1016/0005-2744(80)90283-1	1980
Enzymology	The solubilisation of the membrane-bound D-alanyl-D-alanine carboxypeptidase of Bacillus coagulans NCIB 9365.	McArthur HA, Reynolds PE	Biochim Biophys Acta	10.1016/0005-2744(79)90308-5	1979
Enzymology	Thermal inactivation kinetics of Bacillus coagulans spores in tomato juice.	Peng J, Mah JH, Somavat R, Mohamed H, Sastry S, Tang J	J Food Prot	10.4315/0362-028X.JFP-11-490	2012
	In vitro assessment of probiotic attributes for strains contained in commercial formulations.	Mazzantini D, Calvigioni M, Celandroni F, Lupetti A, Ghelardi E	Sci Rep	10.1038/s41598-022-25688-z	2022
Phylogeny	Bacillus acidiproducens sp. nov., vineyard soil isolates that produce lactic acid.	Jung MY, Kim JS, Chang YH	Int J Syst Evol Microbiol	10.1099/ijs.0.003913-0	2009
Phylogeny	Streptomyces pharetrae sp. nov., isolated from soil from the semi-arid Karoo region.	le Roes M, Meyers PR	Syst Appl Microbiol	10.1016/j.syapm.2005.03.006	2005
Phylogeny	Weizmannia faecalis sp. nov., isolated from a human stool sample.	Kieu HT, Pham TPT, Lo CI, Alibar S, Brechard L, Armstrong N, Decloquement P, Diallo A, Sokhna C, Million M, Lagier JC, Raoult D, Tidjani Alou M	Arch Microbiol	10.1007/s00203-022-03229-6	2022

References

#2009	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 1
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20216	Curators of the HKI: Collection Description Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI) . Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. Hans-Knöll-Institut (HKI):
#22893	Min Young Jung, Joong-Su Kim, Young-Hyo Chang: Bacillus acidiproducens sp. nov., vineyard soil isolates that produce lactic acid. IJSEM 59: 2226 - 2231 2009 ( DOI 10.1099/ijs.0.003913-0 , PubMed 19605722 )
#22894	LAWRENCE K. NAKAMURA*, INGE BLUMENSTOCK, DIETER CLAUS: Taxonomic Study of Bacillus coagulans Hammer 1915 with a Proposal for Bacillus smithii sp. nov.. IJSEM 38: 63 - 73 1988 ( DOI 10.1099/00207713-38-1-63 )
#41798	; Curators of the CIP;
#44986	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 7417
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68379	Automatically annotated from API Coryne .
#68382	Automatically annotated from API zym .
#118318	Collection of Institut Pasteur ; Curators of the CIP; CIP 66.25
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Bacillus coagulans (DSM 1, CCM 2013, NCIB 9365)

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