Roseburia intestinalis (DSM 14610, CIP 107878, JCM 17583)

Name: Roseburia intestinalis (DSM 14610, CIP 107878, JCM 17583)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6366

Type strain

Strain Designation L1-82

Culture col. no. DSM 14610 CIP 107878 JCM 17583 NCIMB 13810 L1-82 1 more

NCBI tax ID(s) 166486

Special Collections DSMZ JCM CIP

History <- S. Duncan; L1-82 DSM 14610 <-- S. Duncan L1-82.

Links

Roseburia intestinalis L1-82 is a mesophilic prokaryote that was isolated from infant faeces.

mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 100933

JCM 17583,DSM 14610,NCIMB 13810,CIP107878,VTT E-052785

@ref 20215

Last LPSN update 2026-02-09 11:19:12

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Lachnospiraceae

Genus Roseburia

Species Roseburia intestinalis

Full scientific name Roseburia intestinalis Duncan et al. 2002

BacDive ID	Other strains from **Roseburia intestinalis** (1)	Type strain
163990	R. intestinalis JCM 31262

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
5410	YCFA-MEDIUM (MODIFIED) (DSMZ Medium 1611)		Medium recipe at MediaDive	Name: YCFA MEDIUM (modified) (DSMZ Medium 1611) Composition: Casitone 10.0 g/l Glucose 5.0 g/l NaHCO3 4.0 g/l Yeast extract 2.5 g/l Acetic acid 1.78695 g/l L-Cysteine HCl 1.0 g/l NaCl 0.9 g/l Propionic acid 0.62559 g/l KH2PO4 0.45 g/l K2HPO4 0.45 g/l CaCl2 x 2 H2O 0.09 g/l n-Valeric acid 0.08451 g/l iso-Valeric acid 0.0837899 g/l iso-Butyric acid 0.07695 g/l MgSO4 x 7 H2O 0.045 g/l Hemin 0.01 g/l Resazurin 0.001 g/l Pyridoxine hydrochloride 0.0001 g/l Nicotinic acid 5e-05 g/l Thiamine-HCl x 2 H2O 5e-05 g/l Riboflavin 5e-05 g/l D-Calcium pantothenate 5e-05 g/l p-Aminobenzoic acid 5e-05 g/l Lipoic acid 5e-05 g/l Folic acid 2e-05 g/l Biotin 2e-05 g/l Vitamin B12 1e-06 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
5410	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125438	anaerobe	90.793
125439	anaerobe	99.9

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	+	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68380	alpha-galactosidase	+	3.2.1.22	from API rID32A
68380	alpha-glucosidase	+	3.2.1.20	from API rID32A
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	+	3.2.1.21	from API rID32A
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
5410	-	-	+	+	-	+	+	+	-	+	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
5410	-	+/-	+	+	-	+	+	+	-	+/-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
5410	-	-	+	+	-	+	+	+	-	+/-	-	-	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-
5410	-	-	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
5410	-	-	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
5410	-	-	+	+	-	+	+	+	-	+	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	+	+	-	-
5410	-	-	+	+	-	+	+	+	-	+	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
5410	-	-	+	+	-	+	+	+	-	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Patient	-
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)
#Host	#Human	#Child

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
5410	infant faeces	Scotland, Aberdeen	United Kingdom	GBR	Europe
67770	Healthy infant fecal samples

Taxonmaps

69479

Global distribution of 16S sequence HM007565 (>99% sequence identity) for Roseburia intestinalis subclade from Microbeatlas

Aquatic Samples	311
Soil Samples	217
Animal Samples	37648
Plant Samples	44
Total Samples	38220

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
5410	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Roseburia intestinalis strain L1-82 assembly for Roseburia intestinalis L1-82	complete	GCA_900537995	536231.75	2836830276	536231	92.83
66792	ASM15653v1 assembly for Roseburia intestinalis L1-82	scaffold	GCA_000156535	536231.5	2562617159	536231

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Roseburia intestinalis strain DSM 14610 16S ribosomal RNA gene, partial sequence	HM007565	1329	166486
5410	Roseburia intestinalis 16S rRNA gene, strain L1-82	AJ312385	1482	536231
67770	Roseburia intestinalis gene for 16S ribosomal RNA, partial sequence, strain: JCM 17583	AB661435	1494	166486

GC content

@ref	GC-content (mol%)	Method
67770	31	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Roseburia intestinalis L1-82
NCBI: GCA_900537995

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	77.30	no
125439	motility	BacteriaNetⓘ	yes	78.40	no
125439	gram_stain	BacteriaNetⓘ	positive	73.90	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.90	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Roseburia intestinalis L1-82 L1-82
NCBI: GCA_900537995.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	69.94	no
125438	anaerobic	anaerobicⓘ	yes	90.79	no
125438	aerobic	aerobicⓘ	no	96.75	no
125438	spore-forming	spore-formingⓘ	yes	53.15	no
125438	thermophilic	thermophileⓘ	no	93.69	yes
125438	flagellated	motile2+ⓘ	yes	73.06	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Specific gFET-Based Aptasensors for Monitoring of Microbiome Quality: Quantification of the Enteric Health-Relevant Bacterium Roseburia Intestinalis.	Zhang Y, Xing H, Li R, Andersson J, Bozdogan A, Strassl R, Draphoen B, Linden M, Henkel M, Knippschild U, Hasler R, Kleber C, Knoll W, Kissmann AK, Rosenau F.	Adv Healthc Mater	10.1002/adhm.202403827	2025
Genetics	Growth stage and interspecies interactions shape the cell biology and cell cycle characteristics of human gut bacteria Bacteroides thetaiotaomicron and Roseburia intestinalis.	Liu B, Sondervorst K, Nesporova K, Faust K, Govers SK.	Commun Biol	10.1038/s42003-025-08949-1	2025
	Oral administration of pioglitazone inhibits pulmonary hypertension by regulating the gut microbiome and plasma metabolome in male rats.	Zhang Z, Liang Y, Mo S, Zhao M, Li Y, Zhang C, Shan X, Liu S, Liao J, Luo X, Zhu J, Wang C, Jiang Q, Hou C, Hong W, Lai N, Chen Y, Xu L, Lu W, Wang J, Wang Z, Yang K.	Physiol Rep	10.14814/phy2.70174	2025
	A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein.	Leonard LM, Simpson AMR, Li S, Reddivari L, Cross TL.	Nutrients	10.3390/nu16071079	2024
	Technical versus biological variability in a synthetic human gut community.	van de Velde C, Joseph C, Simoens K, Raes J, Bernaerts K, Faust K.	Gut Microbes	10.1080/19490976.2022.2155019	2023
Pathogenicity	Gut microbiota controls the development of chronic pancreatitis: A critical role of short-chain fatty acids-producing Gram-positive bacteria.	Pan LL, Ren ZN, Yang J, Li BB, Huang YW, Song DX, Li X, Xu JJ, Bhatia M, Zou DW, Zhou CH, Sun J.	Acta Pharm Sin B	10.1016/j.apsb.2023.08.002	2023
	Development of culture methods capable of culturing a wide range of predominant species of intestinal bacteria.	Hirano R, Nishita I, Nakai R, Bito A, Sasabe R, Kurihara S.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1056866	2023
	Environmental factors drive bacterial degradation of gastrointestinal mucus.	Arias SL, van Wijngaarden EW, Balint D, Jones J, Crawford CC, Shukla PJ, Silberstein M, Brito IL.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00741-7	2025
	The Therapeutic Role of Short-Chain Fatty Acids Mediated Very Low-Calorie Ketogenic Diet-Gut Microbiota Relationships in Paediatric Inflammatory Bowel Diseases.	Alsharairi NA.	Nutrients	10.3390/nu14194113	2022
	SEMQuant: Extending Sipros-Ensemble with Match-Between-Runs for Comprehensive Quantitative Metaproteomics.	Zhang B, Feng S, Parajuli M, Xiong Y, Pan C, Guo X.	Bioinform Res Appl	10.1007/978-981-97-5087-0_9	2024
	A Polyclonal Aptamer Library for the Specific Binding of the Gut Bacterium Roseburia intestinalis in Mixtures with Other Gut Microbiome Bacteria and Human Stool Samples.	Xing H, Zhang Y, Kramer M, Kissmann AK, Amann V, Raber HF, Weil T, Stieger KR, Knippschild U, Henkel M, Andersson J, Rosenau F.	Int J Mol Sci	10.3390/ijms23147744	2022
	Roseburia intestinalis: A Beneficial Gut Organism From the Discoveries in Genus and Species.	Nie K, Ma K, Luo W, Shen Z, Yang Z, Xiao M, Tong T, Yang Y, Wang X.	Front Cell Infect Microbiol	10.3389/fcimb.2021.757718	2021
	Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility.	Wolter M, Grant ET, Boudaud M, Pudlo NA, Pereira GV, Eaton KA, Martens EC, Desai MS.	Mol Syst Biol	10.1038/s44320-024-00036-7	2024
Pathogenicity	Quantifying the varying harvest of fermentation products from the human gut microbiota.	Arnoldini M, Sharma R, Moresi C, Chure G, Chabbey J, Slack E, Cremer J.	Cell	10.1016/j.cell.2025.07.005	2025
	Phylogenetic diversity of core rumen microbiota as described by cryo-ET.	Wimmer BH, Morais S, Zalk R, Mizrahi I, Medalia O.	Microlife	10.1093/femsml/uqad010	2023
Genetics	The estrobolome: Estrogen-metabolizing pathways of the gut microbiome and their relation to breast cancer.	Larnder AH, Manges AR, Murphy RA.	Int J Cancer	10.1002/ijc.35427	2025
	The waxy mutation in sorghum and other cereal grains reshapes the gut microbiome by reducing levels of multiple beneficial species.	Yang Q, Van Haute M, Korth N, Sattler S, Rose D, Juritsch A, Shao J, Beede K, Schmaltz R, Price J, Toy J, Ramer-Tait AE, Benson AK.	Gut Microbes	10.1080/19490976.2023.2178799	2023
	Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria.	de Ram C, Berkhout MD, O Pandeirada C, Vincken JP, Hooiveld GJEJ, Belzer C, Schols HA.	FEMS Microbiol Ecol	10.1093/femsec/fiaf066	2025
	Dietary Melanoidins from Biscuits and Bread Crust Alter the Structure and Short-Chain Fatty Acid Production of Human Gut Microbiota.	Rajakaruna S, Perez-Burillo S, Kramer DL, Rufian-Henares JA, Paliy O.	Microorganisms	10.3390/microorganisms10071268	2022
	Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health.	Xiao M, Zhang C, Duan H, Narbad A, Zhao J, Chen W, Zhai Q, Yu L, Tian F.	NPJ Biofilms Microbiomes	10.1038/s41522-024-00524-6	2024
	Fast quantification of gut bacterial species in cocultures using flow cytometry and supervised classification.	van de Velde CC, Joseph C, Biclot A, Huys GRB, Pinheiro VB, Bernaerts K, Raes J, Faust K.	ISME Commun	10.1038/s43705-022-00123-6	2022
	Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes.	Matsumoto W, Takemura M, Nanaura H, Ami Y, Maoka T, Shindo K, Kurihara S, Misawa N.	Eng Microbiol	10.1016/j.engmic.2024.100147	2024
Pathogenicity	Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation.	Chervet A, Nehme R, Defois-Fraysse C, Decombat C, Blavignac C, Auxenfans C, Evrard B, Michel S, Filaire E, Berthon JY, Dreux-Zigha A, Delort L, Caldefie-Chezet F.	Curr Res Food Sci	10.1016/j.crfs.2025.100974	2025
Pathogenicity	Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host-microbe cross talk.	Steimle A, De Sciscio A, Neumann M, Grant ET, Pereira GV, Ohno H, Martens EC, Desai MS.	STAR Protoc	10.1016/j.xpro.2021.100607	2021
Pathogenicity	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease.	Yu S, Li C, Ji G, Zhang L.	Front Pharmacol	10.3389/fphar.2021.783393	2021
	Barrier Protection and Recovery Effects of Gut Commensal Bacteria on Differentiated Intestinal Epithelial Cells In Vitro.	Mohebali N, Ekat K, Kreikemeyer B, Breitruck A.	Nutrients	10.3390/nu12082251	2020
	A Polyclonal Selex Aptamer Library Directly Allows Specific Labelling of the Human Gut Bacterium Blautia producta without Isolating Individual Aptamers.	Xing H, Zhang Y, Kramer M, Kissmann AK, Henkel M, Weil T, Knippschild U, Rosenau F.	Molecules	10.3390/molecules27175693	2022
	Dynamic metabolic interactions and trophic roles of human gut microbes identified using a minimal microbiome exhibiting ecological properties.	Shetty SA, Kostopoulos I, Geerlings SY, Smidt H, de Vos WM, Belzer C.	ISME J	10.1038/s41396-022-01255-2	2022
	Polyclonal Aptamers for Specific Fluorescence Labeling and Quantification of the Health Relevant Human Gut Bacterium Parabacteroides distasonis.	Xing H, Kissmann AK, Raber HF, Kramer M, Amann V, Kohn K, Weil T, Rosenau F.	Microorganisms	10.3390/microorganisms9112284	2021
	Opposing diet, microbiome, and metabolite mechanisms regulate inflammatory bowel disease in a genetically susceptible host.	Pereira GV, Boudaud M, Wolter M, Alexander C, De Sciscio A, Grant ET, Trindade BC, Pudlo NA, Singh S, Campbell A, Shan M, Zhang L, Yang Q, Willieme S, Kim K, Denike-Duval T, Fuentes J, Bleich A, Schmidt TM, Kennedy L, Lyssiotis CA, Chen GY, Eaton KA, Desai MS, Martens EC.	Cell Host Microbe	10.1016/j.chom.2024.03.001	2024
Metabolism	Chitosan Oligosaccharides Show Protective Effects in Coronary Heart Disease by Improving Antioxidant Capacity via the Increase in Intestinal Probiotics.	Jiang T, Xing X, Zhang L, Liu Z, Zhao J, Liu X.	Oxid Med Cell Longev	10.1155/2019/7658052	2019
	Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.	Sugihara K, Kitamoto S, Saraithong P, Nagao-Kitamoto H, Hoostal M, McCarthy C, Rosevelt A, Muraleedharan CK, Gillilland MG, Imai J, Omi M, Bishu S, Kao JY, Alteri CJ, Barnich N, Schmidt TM, Nusrat A, Inohara N, Golob JL, Kamada N.	Cell Rep	10.1016/j.celrep.2022.111093	2022
	Maternal diet and gut microbiome composition modulate early-life immune development.	Grant ET, Boudaud M, Muller A, Muller A, Macpherson AJ, Desai MS.	EMBO Mol Med	10.15252/emmm.202217241	2023
Metabolism	Gut microbial beta-glucuronidase and glycerol/diol dehydratase activity contribute to dietary heterocyclic amine biotransformation.	Zhang J, Lacroix C, Wortmann E, Ruscheweyh HJ, Sunagawa S, Sturla SJ, Schwab C.	BMC Microbiol	10.1186/s12866-019-1483-x	2019
Pathogenicity	The Butyrogenic and Lactic Bacteria of the Gut Microbiota Determine the Outcome of Allogenic Hematopoietic Cell Transplant.	Devaux CA, Million M, Raoult D.	Front Microbiol	10.3389/fmicb.2020.01642	2020
	The Unique Seed Protein Composition of Quality Protein Popcorn Promotes Growth of Beneficial Bacteria From the Human Gut Microbiome.	Korth N, Parsons L, Van Haute MJ, Yang Q, Hurst P, Schnable JC, Holding DR, Benson AK.	Front Microbiol	10.3389/fmicb.2022.921456	2022
	Assessment of Gram- and Viability-Staining Methods for Quantifying Bacterial Community Dynamics Using Flow Cytometry.	Duquenoy A, Bellais S, Gasc C, Schwintner C, Dore J, Thomas V.	Front Microbiol	10.3389/fmicb.2020.01469	2020
	Effect of cryopreservation and lyophilization on viability and growth of strict anaerobic human gut microbes.	Bircher L, Geirnaert A, Hammes F, Lacroix C, Schwab C.	Microb Biotechnol	10.1111/1751-7915.13265	2018
Metabolism	Wheat bran promotes enrichment within the human colonic microbiota of butyrate-producing bacteria that release ferulic acid.	Duncan SH, Russell WR, Quartieri A, Rossi M, Parkhill J, Walker AW, Flint HJ.	Environ Microbiol	10.1111/1462-2920.13158	2016
	Inter-species Metabolic Interactions in an In-vitro Minimal Human Gut Microbiome of Core Bacteria.	Shetty SA, Kuipers B, Atashgahi S, Aalvink S, Smidt H, de Vos WM.	NPJ Biofilms Microbiomes	10.1038/s41522-022-00275-2	2022
	Gut Microbiota Confers Resistance of Albino Oxford Rats to the Induction of Experimental Autoimmune Encephalomyelitis.	Stanisavljevic S, Dinic M, Jevtic B, Dedovic N, Momcilovic M, Dokic J, Golic N, Mostarica Stojkovic M, Miljkovic D.	Front Immunol	10.3389/fimmu.2018.00942	2018
	Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.	Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascuena AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M.	Nat Commun	10.1038/s41467-023-37533-6	2023
	Microorganisms linked to inflammatory bowel disease-associated dysbiosis differentially impact host physiology in gnotobiotic mice.	Hoffmann TW, Pham HP, Bridonneau C, Aubry C, Lamas B, Martin-Gallausiaux C, Moroldo M, Rainteau D, Lapaque N, Six A, Richard ML, Fargier E, Le Guern ME, Langella P, Sokol H.	ISME J	10.1038/ismej.2015.127	2016
	Developing standards for the microbiome field.	Amos GCA, Logan A, Anwar S, Fritzsche M, Mate R, Bleazard T, Rijpkema S.	Microbiome	10.1186/s40168-020-00856-3	2020
	Next-generation prebiotic promotes selective growth of bifidobacteria, suppressing Clostridioides difficile.	Hirano R, Sakanaka M, Yoshimi K, Sugimoto N, Eguchi S, Yamauchi Y, Nara M, Maeda S, Ami Y, Gotoh A, Katayama T, Iida N, Kato T, Ohno H, Fukiya S, Yokota A, Nishimoto M, Kitaoka M, Nakai H, Kurihara S.	Gut Microbes	10.1080/19490976.2021.1973835	2021
	Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.	Riviere A, Selak M, Lantin D, Leroy F, De Vuyst L.	Front Microbiol	10.3389/fmicb.2016.00979	2016
Metabolism	Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics.	Baranwal M, Clark RL, Thompson J, Sun Z, Hero AO, Venturelli OS.	Elife	10.7554/elife.73870	2022
	Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease.	Lambertz J, Weiskirchen S, Landert S, Weiskirchen R.	Front Immunol	10.3389/fimmu.2017.01159	2017
Pathogenicity	Procyanidin-Cell Wall Interactions within Apple Matrices Decrease the Metabolization of Procyanidins by the Human Gut Microbiota and the Anti-Inflammatory Effect of the Resulting Microbial Metabolome In Vitro.	Le Bourvellec C, Bagano Vilas Boas P, Lepercq P, Comtet-Marre S, Auffret P, Ruiz P, Bott R, Renard CMGC, Dufour C, Chatel JM, Mosoni P.	Nutrients	10.3390/nu11030664	2019
	The metabolic activity of gut microbiota in obese children is increased compared with normal-weight children and exhibits more exhaustive substrate utilization.	Payne AN, Chassard C, Zimmermann M, Muller P, Stinca S, Lacroix C.	Nutr Diabetes	10.1038/nutd.2011.8	2011
	Proteomic indicators of oxidation and hydration state in colorectal cancer.	Dick JM.	PeerJ	10.7717/peerj.2238	2016
	A Dietary Fiber-Deprived Gut Microbiota Degrades the Colonic Mucus Barrier and Enhances Pathogen Susceptibility.	Desai MS, Seekatz AM, Koropatkin NM, Kamada N, Hickey CA, Wolter M, Pudlo NA, Kitamoto S, Terrapon N, Muller A, Young VB, Henrissat B, Wilmes P, Stappenbeck TS, Nunez G, Martens EC.	Cell	10.1016/j.cell.2016.10.043	2016
Metabolism	pH and peptide supply can radically alter bacterial populations and short-chain fatty acid ratios within microbial communities from the human colon.	Walker AW, Duncan SH, McWilliam Leitch EC, Child MW, Flint HJ.	Appl Environ Microbiol	10.1128/aem.71.7.3692-3700.2005	2005
Enzymology	Enterohepatic helicobacter in ulcerative colitis: potential pathogenic entities?	Thomson JM, Hansen R, Berry SH, Hope ME, Murray GI, Mukhopadhya I, McLean MH, Shen Z, Fox JG, El-Omar E, Hold GL.	PLoS One	10.1371/journal.pone.0017184	2011
	New pathway ameliorating ulcerative colitis: focus on Roseburia intestinalis and the gut-brain axis.	Xu F, Cheng Y, Ruan G, Fan L, Tian Y, Xiao Z, Chen D, Wei Y.	Therap Adv Gastroenterol	10.1177/17562848211004469	2021
Metabolism	Characterization of fructooligosaccharide metabolism and fructooligosaccharide-degrading enzymes in human commensal butyrate producers.	Tanno H, Fujii T, Hirano K, Maeno S, Tonozuka T, Sakamoto M, Ohkuma M, Tochio T, Endo A.	Gut Microbes	10.1080/19490976.2020.1869503	2021
	Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120.	Hagihara M, Yamashita M, Ariyoshi T, Minemura A, Yoshida C, Higashi S, Oka K, Takahashi M, Ota A, Maenaka A, Iwasaki K, Hirai J, Shibata Y, Umemura T, Mori T, Kato H, Asai N, Mikamo H.	iScience	10.1016/j.isci.2025.113502	2025
Phylogeny	Bacterial communities in women with bacterial vaginosis: high resolution phylogenetic analyses reveal relationships of microbiota to clinical criteria.	Srinivasan S, Hoffman NG, Morgan MT, Matsen FA, Fiedler TL, Hall RW, Ross FJ, McCoy CO, Bumgarner R, Marrazzo JM, Fredricks DN.	PLoS One	10.1371/journal.pone.0037818	2012
Enzymology	The enemy from within: a prophage of Roseburia intestinalis systematically turns lytic in the mouse gut, driving bacterial adaptation by CRISPR spacer acquisition.	Cornuault JK, Moncaut E, Loux V, Mathieu A, Sokol H, Petit MA, De Paepe M	ISME J	10.1038/s41396-019-0566-x	2019
Metabolism	Integrated culturing, modeling and transcriptomics uncovers complex interactions and emergent behavior in a three-species synthetic gut community.	D'hoe K, Vet S, Faust K, Moens F, Falony G, Gonze D, Llorens-Rico V, Gelens L, Danckaert J, De Vuyst L, Raes J	Elife	10.7554/eLife.37090	2018
Metabolism	In vitro kinetics of prebiotic inulin-type fructan fermentation by butyrate-producing colon bacteria: implementation of online gas chromatography for quantitative analysis of carbon dioxide and hydrogen gas production.	Falony G, Verschaeren A, De Bruycker F, De Preter V, Verbeke K, Leroy F, De Vuyst L	Appl Environ Microbiol	10.1128/AEM.00876-09	2009
Metabolism	Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose.	Falony G, Vlachou A, Verbrugghe K, De Vuyst L	Appl Environ Microbiol	10.1128/AEM.01296-06	2006
Pathogenicity	Effects of alternative dietary substrates on competition between human colonic bacteria in an anaerobic fermentor system.	Duncan SH, Scott KP, Ramsay AG, Harmsen HJ, Welling GW, Stewart CS, Flint HJ	Appl Environ Microbiol	10.1128/AEM.69.2.1136-1142.2003	2003
Metabolism	Peanuts as a nighttime snack enrich butyrate-producing bacteria compared to an isocaloric lower-fat higher-carbohydrate snack in adults with elevated fasting glucose: A randomized crossover trial.	Sapp PA, Kris-Etherton PM, Arnesen EA, Chen See JR, Lamendella R, Petersen KS	Clin Nutr	10.1016/j.clnu.2022.08.004	2022
Phylogeny	Butyribacter intestini gen. nov., sp. nov., a butyric acid-producing bacterium of the family Lachnospiraceae isolated from human faeces, and reclassification of Acetivibrio ethanolgignens as Acetanaerobacter ethanolgignens gen. nov., comb. nov.	Zou Y, Xue W, Lin X, Lv M, Luo G, Dai Y, Sun H, Liu SW, Sun CH, Hu T, Xiao L	Syst Appl Microbiol	10.1016/j.syapm.2021.126201	2021
Phylogeny	Proposal of Roseburia faecis sp. nov., Roseburia hominis sp. nov. and Roseburia inulinivorans sp. nov., based on isolates from human faeces.	Duncan SH, Aminov RI, Scott KP, Louis P, Stanton TB, Flint HJ	Int J Syst Evol Microbiol	10.1099/ijs.0.64098-0	2006
Phylogeny	Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces.	Duncan SH, Hold GL, Barcenilla A, Stewart CS, Flint HJ	Int J Syst Evol Microbiol	10.1099/00207713-52-5-1615	2002

References

#5410	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 14610
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68380	Automatically annotated from API rID32A .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Roseburia intestinalis (DSM 14610, CIP 107878, JCM 17583)

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