Anaerostipes caccae (DSM 14662, CIP 108612, NCIMB 13811)

Name: Anaerostipes caccae (DSM 14662, CIP 108612, NCIMB 13811)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6339

Type strain

Strain Designation L1-92

Culture col. no. DSM 14662 CIP 108612 NCIMB 13811 CCUG 47493 L1-92 3 more

NCBI tax ID(s) 411490 105841

Special Collections DSMZ CCUG JCM CIP KCTC

History <- S. Duncan; L1-92 DSM 14662 <-- S. Duncan L1-92. CIP <- 2005, J.P. Carlier, Inst. Pasteur, Paris, France: strain AIP 10223 <- DSM <- S. Duncan: strain L1-92

Links

Anaerostipes caccae L1-92 is an anaerobe, mesophilic, Gram-positive prokaryote that was isolated from human faeces.

Gram-positive rod-shaped anaerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 100506

DSM 14662,NCIMB 13811,CCUG 47493,JCM 13470,CIP 108612,VTT E-052773,KCTC 15019,LMG 28898

@ref 20215

Last LPSN update 2026-02-09 11:19:11

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Lachnospiraceae

Genus Anaerostipes

Species Anaerostipes caccae

Full scientific name Anaerostipes caccae Schwiertz et al. 2002

BacDive ID	Other strains from **Anaerostipes caccae** (1)	Type strain
156701	A. caccae CCUG 64219

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
117086	positive	rod-shaped

Colony morphology

@ref	Incubation period
57715	1 day
117086

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
5469	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)	Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
34329	MEDIUM 20 - for Anaerobic bacteria		Agar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)
117086	CIP Medium 20	Medium recipe at CIP
5469	SCHAEDLER BROTH (ROTH; 5772) (DSMZ Medium 1669)	Medium recipe at MediaDive	Name: SCHAEDLER BROTH (ROTH; 5772) (DSMZ Medium 1669) Composition: Glucose 5.83 g/l Casein peptone 5.66 g/l Yeast extract 5.0 g/l Peptone mixture 5.0 g/l Tris 3.0 g/l NaCl 1.66 g/l Soy peptone 1.0 g/l K2HPO4 0.83 g/l L-Cysteine HCl x H2O 0.4 g/l Hemin 0.01 g/l Resazurin 0.001 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
5469	positive	growth	37	mesophilic
34329	positive	growth	37	mesophilic
57715	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
5469	anaerobe
57715	anaerobe
117086	anaerobe
125439	anaerobe	99.5

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
117086	17632 ChEBI	nitrate	-	reduction
117086	16301 ChEBI	nitrite	-	reduction
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A
117086	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
117086	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68380	alpha-glucosidase	-	3.2.1.20	from API rID32A
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	-	3.2.1.23	from API zym
68380	beta-galactosidase	-	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	-	3.2.1.21	from API zym
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
117086	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
68382	leucine arylamidase	-	3.4.11.1	from API zym
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68382	lipase (C 14)	-		from API zym
117086	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
117086	ornithine decarboxylase	-	4.1.1.17
117086	oxidase	-
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68382	trypsin	-	3.4.21.4	from API zym
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
117086	urease	-	3.5.1.5
68380	urease	-	3.5.1.5	from API rID32A
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
117086	-	-	-	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
5469	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
5469	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	not determinedn.d.	-	-	-	-	-
5469	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
5469	human faeces	United Kingdom	GBR	Europe
57715	Human feces	United Kingdom	GBR	Europe
67770	Human feces
117086	Human, Faeces	United Kingdom	GBR	Europe

Taxonmaps

69479

Global distribution of 16S sequence AJ270487 (>99% sequence identity) for Anaerostipes caccae subclade from Microbeatlas

Aquatic Samples	980
Soil Samples	321
Animal Samples	75194
Plant Samples	183
Total Samples	76678

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
5469	1	Risk group (German classification) According to TRBA 466
117086	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1413167v1 assembly for Anaerostipes caccae L1-92 DSM 14662	complete	GCA_014131675	105841.35		411490	96.99
66792	ASM1446707v1 assembly for Anaerostipes caccae L1-92 JCM 13470	complete	GCA_014467075	105841.45		411490	96.99
66792	ASM2514600v1 assembly for Anaerostipes caccae L1-92 DSM 14662	complete	GCA_025146005	411490.43		411490	95.22
67770	ASM15430v1 assembly for Anaerostipes caccae L1-92 DSM 14662	scaffold	GCA_000154305	411490.6	641736227	411490	69.01
67770	81B4 assembly for Anaerostipes caccae L1-92	contig	GCA_900624715	411490.34		411490	66.02

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
5469	Butyrate-producing bacterium L1-92 16S rRNA gene	AJ270487	1456		105841

GC content

@ref	GC-content (mol%)	Method
5469	46.0	high performance liquid chromatography (HPLC)
67770	46	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Anaerostipes caccae L1-92 DSM 14662
NCBI: GCA_014131675

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.50	no
125439	gram_stain	BacteriaNetⓘ	variable	72.20	no
125439	motility	BacteriaNetⓘ	yes	86.20	no
125439	spore_formation	BacteriaNetⓘ	yes	82.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Anaerostipes caccae L1-92 DSM 14662
NCBI: GCA_014131675.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	76.64	no
125438	anaerobic	anaerobicⓘ	yes	82.33	yes
125438	aerobic	aerobicⓘ	no	97.13	no
125438	spore-forming	spore-formingⓘ	yes	56.99	no
125438	thermophilic	thermophileⓘ	no	94.99	yes
125438	flagellated	motile2+ⓘ	no	75.56	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Gorse (Ulex europeaus) wastes with 5,6-dimethyl benzimidazole supplementation can support growth of vitamin B12 producing commensal gut microbes.	Iyer A, Soto Martin EC, Cameron GA, Louis P, Duncan SH, Bestwick CS, Russell WR.	PLoS One	10.1371/journal.pone.0290052	2024
	A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice.	Hesser LA, Puente AA, Arnold J, Ionescu E, Mirmira A, Talasani N, Lopez J, Maccio-Maretto L, Mimee M, Nagler CR.	Cell Host Microbe	10.1016/j.chom.2024.05.019	2024
	Multi-omics technology reveals the changes in gut microbiota to stimulate aromatic amino acid metabolism in children with allergic rhinitis and constipation.	Wang C, Liu H, Li X, Kong W, Wu H, Huang C.	Front Allergy	10.3389/falgy.2025.1562832	2025
	Faecalibacterium duncaniae Mitigates Intestinal Barrier Damage in Mice Induced by High-Altitude Exposure by Increasing Levels of 2-Ketoglutaric Acid.	Sun X, Li W, Chen G, Hu G, Jia J.	Nutrients	10.3390/nu17081380	2025
	Measuring and understanding information storage and transfer in a simulated human gut microbiome.	Zoller H, Garcia Perez C, Betel Geijo Fernandez J, Zu Castell W.	PLoS Comput Biol	10.1371/journal.pcbi.1012359	2024
	Vitamin B12 analogues from gut microbes and diet differentially impact commensal propionate producers of the human gut.	Kundra P, Greppi A, Duppenthaler M, Pluss S, Pugin B, Lacroix C, Geirnaert A.	Front Nutr	10.3389/fnut.2024.1360199	2024
Pathogenicity	Butyrate producers, "The Sentinel of Gut": Their intestinal significance with and beyond butyrate, and prospective use as microbial therapeutics.	Singh V, Lee G, Son H, Koh H, Kim ES, Unno T, Shin JH.	Front Microbiol	10.3389/fmicb.2022.1103836	2022
	Cross-feeding of bifidobacteria promotes intestinal homeostasis: a lifelong perspective on the host health.	Xiao M, Zhang C, Duan H, Narbad A, Zhao J, Chen W, Zhai Q, Yu L, Tian F.	NPJ Biofilms Microbiomes	10.1038/s41522-024-00524-6	2024
	Bacteroides thetaiotaomicron Fosters the Growth of Butyrate-Producing Anaerostipes caccae in the Presence of Lactose and Total Human Milk Carbohydrates.	Chia LW, Mank M, Blijenberg B, Aalvink S, Bongers RS, Stahl B, Knol J, Belzer C.	Microorganisms	10.3390/microorganisms8101513	2020
	Bacterial microcompartments and energy metabolism drive gut colonization by Bilophila wadsworthia	Sayavedra L, Yasir M, Goldson A, Brion A, Le Gall G, Moreno-Gonzalez M, Altera A, Paxhia M, Warren M, Savva G, Turner A, Beraza N, Narbad A.	Nat Commun		2025
	Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria.	de Ram C, Berkhout MD, O Pandeirada C, Vincken JP, Hooiveld GJEJ, Belzer C, Schols HA.	FEMS Microbiol Ecol	10.1093/femsec/fiaf066	2025
	Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease.	Wang X, Zhao J, Feng Y, Feng Z, Ye Y, Liu L, Kang G, Cao X.	Front Cell Infect Microbiol	10.3389/fcimb.2022.916543	2022
	Stable coexistence between an archaeal virus and the dominant methanogen of the human gut.	Baquero DP, Medvedeva S, Martin-Gallausiaux C, Pende N, Sartori-Rupp A, Tachon S, Pedron T, Debarbieux L, Borrel G, Gribaldo S, Krupovic M.	Nat Commun	10.1038/s41467-024-51946-x	2024
	Healthy infants harbor intestinal bacteria that protect against food allergy.	Feehley T, Plunkett CH, Bao R, Choi Hong SM, Culleen E, Belda-Ferre P, Campbell E, Aitoro R, Nocerino R, Paparo L, Andrade J, Antonopoulos DA, Berni Canani R, Nagler CR.	Nat Med	10.1038/s41591-018-0324-z	2019
Pathogenicity	The Contribution of Dietary Fructose to Non-alcoholic Fatty Liver Disease.	Yu S, Li C, Ji G, Zhang L.	Front Pharmacol	10.3389/fphar.2021.783393	2021
Metabolism	Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach.	Chia LW, Hornung BVH, Aalvink S, Schaap PJ, de Vos WM, Knol J, Belzer C.	Antonie Van Leeuwenhoek	10.1007/s10482-018-1040-x	2018
	Ethanol Production by Selected Intestinal Microorganisms and Lactic Acid Bacteria Growing under Different Nutritional Conditions.	Elshaghabee FM, Bockelmann W, Meske D, de Vrese M, Walte HG, Schrezenmeir J, Heller KJ.	Front Microbiol	10.3389/fmicb.2016.00047	2016
Metabolism	Determination of Butyrate Synthesis Capacity in Gut Microbiota: Quantification of but Gene Abundance by qPCR in Fecal Samples.	Daskova N, Heczkova M, Modos I, Videnska P, Splichalova P, Pelantova H, Kuzma M, Gojda J, Cahova M.	Biomolecules	10.3390/biom11091303	2021
	Short-Chain Fatty Acids and Human Health: From Metabolic Pathways to Current Therapeutic Implications.	Facchin S, Bertin L, Bonazzi E, Lorenzon G, De Barba C, Barberio B, Zingone F, Maniero D, Scarpa M, Ruffolo C, Angriman I, Savarino EV.	Life (Basel)	10.3390/life14050559	2024
	Carbohydrate complexity limits microbial growth and reduces the sensitivity of human gut communities to perturbations.	Ostrem Loss E, Thompson J, Cheung PLK, Qian Y, Venturelli OS.	Nat Ecol Evol	10.1038/s41559-022-01930-9	2023
Pathogenicity	Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.	Ring C, Klopfleisch R, Dahlke K, Basic M, Bleich A, Blaut M.	Gut Microbes	10.1080/19490976.2018.1511663	2019
Genetics	Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids.	Yoshida T, Claverie JM, Ogata H.	Virol J	10.1186/1743-422x-8-427	2011
	Effect of cryopreservation and lyophilization on viability and growth of strict anaerobic human gut microbes.	Bircher L, Geirnaert A, Hammes F, Lacroix C, Schwab C.	Microb Biotechnol	10.1111/1751-7915.13265	2018
Metabolism	Clostridium ramosum regulates enterochromaffin cell development and serotonin release.	Mandic AD, Woting A, Jaenicke T, Sander A, Sabrowski W, Rolle-Kampcyk U, von Bergen M, Blaut M.	Sci Rep	10.1038/s41598-018-38018-z	2019
	Design, Biological Evaluation, and Computer-Aided Analysis of Dihydrothiazepines as Selective Antichlamydial Agents.	de Campos LJ, Seleem MA, Feng J, Pires de Oliveira KM, de Andrade Dos Santos JV, Hayer S, Clayton JB, Kathi S, Fisher DJ, Ouellette SP, Conda-Sheridan M.	J Med Chem	10.1021/acs.jmedchem.2c01894	2023
Metabolism	Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome.	Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA.	Cell	10.1016/j.cell.2023.05.037	2023
	High-quality-draft genome sequence of the fermenting bacterium Anaerobium acetethylicum type strain GluBS11^T (DSM 29698).	Patil Y, Muller N, Schink B, Whitman WB, Huntemann M, Clum A, Pillay M, Palaniappan K, Varghese N, Mikhailova N, Stamatis D, Reddy TBK, Daum C, Shapiro N, Ivanova N, Kyrpides N, Woyke T, Junghare M.	Stand Genomic Sci	10.1186/s40793-017-0236-4	2017
Enzymology	Muramidases found in the foregut microbiome of the Tammar wallaby can direct cell aggregation and biofilm formation.	Pope PB, Totsika M, Aguirre de Carcer D, Schembri MA, Morrison M.	ISME J	10.1038/ismej.2010.116	2011
Pathogenicity	Computer-guided design of optimal microbial consortia for immune system modulation.	Stein RR, Tanoue T, Szabady RL, Bhattarai SK, Olle B, Norman JM, Suda W, Oshima K, Hattori M, Gerber GK, Sander C, Honda K, Bucci V.	Elife	10.7554/elife.30916	2018
	BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities.	Bauer E, Zimmermann J, Baldini F, Thiele I, Kaleta C.	PLoS Comput Biol	10.1371/journal.pcbi.1005544	2017
Metabolism	Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics.	Baranwal M, Clark RL, Thompson J, Sun Z, Hero AO, Venturelli OS.	Elife	10.7554/elife.73870	2022
	Design, construction, and in vivo augmentation of a complex gut microbiome.	Cheng AG, Ho PY, Aranda-Diaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA.	Cell	10.1016/j.cell.2022.08.003	2022
Pathogenicity	The Butyrogenic and Lactic Bacteria of the Gut Microbiota Determine the Outcome of Allogenic Hematopoietic Cell Transplant.	Devaux CA, Million M, Raoult D.	Front Microbiol	10.3389/fmicb.2020.01642	2020
Metabolism	Butyrate-producing bacteria supplemented in vitro to Crohn's disease patient microbiota increased butyrate production and enhanced intestinal epithelial barrier integrity.	Geirnaert A, Calatayud M, Grootaert C, Laukens D, Devriese S, Smagghe G, De Vos M, Boon N, Van de Wiele T.	Sci Rep	10.1038/s41598-017-11734-8	2017
	Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut.	Riviere A, Selak M, Lantin D, Leroy F, De Vuyst L.	Front Microbiol	10.3389/fmicb.2016.00979	2016
Metabolism	The Activation of Mucosal-Associated Invariant T (MAIT) Cells Is Affected by Microbial Diversity and Riboflavin Utilization in vitro.	Krause JL, Schape SS, Schattenberg F, Muller S, Ackermann G, Rolle-Kampczyk UE, Jehmlich N, Pierzchalski A, von Bergen M, Herberth G.	Front Microbiol	10.3389/fmicb.2020.00755	2020
Genetics	A phylogenomic view of ecological specialization in the Lachnospiraceae, a family of digestive tract-associated bacteria.	Meehan CJ, Beiko RG.	Genome Biol Evol	10.1093/gbe/evu050	2014
Metabolism	Clostridium ramosum promotes high-fat diet-induced obesity in gnotobiotic mouse models.	Woting A, Pfeiffer N, Loh G, Klaus S, Blaut M.	mBio	10.1128/mbio.01530-14	2014
Pathogenicity	The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut.	Elzinga J, van der Oost J, de Vos WM, Smidt H.	Microbiol Mol Biol Rev	10.1128/mmbr.00054-18	2019
	Fructose: A Dietary Sugar in Crosstalk with Microbiota Contributing to the Development and Progression of Non-Alcoholic Liver Disease.	Lambertz J, Weiskirchen S, Landert S, Weiskirchen R.	Front Immunol	10.3389/fimmu.2017.01159	2017
Metabolism	Polysaccharide utilization loci in Bacteroides determine population fitness and community-level interactions.	Feng J, Qian Y, Zhou Z, Ertmer S, Vivas EI, Lan F, Hamilton JJ, Rey FE, Anantharaman K, Venturelli OS.	Cell Host Microbe	10.1016/j.chom.2021.12.006	2022
	Identification of three novel superantigen-encoding genes in Streptococcus equi subsp. zooepidemicus, szeF, szeN, and szeP.	Paillot R, Darby AC, Robinson C, Wright NL, Steward KF, Anderson E, Webb K, Holden MT, Efstratiou A, Broughton K, Jolley KA, Priestnall SL, Marotti Campi MC, Hughes MA, Radford A, Erles K, Waller AS.	Infect Immun	10.1128/iai.00751-10	2010
	Functional environmental screening of a metagenomic library identifies stlA; a unique salt tolerance locus from the human gut microbiome.	Culligan EP, Sleator RD, Marchesi JR, Hill C.	PLoS One	10.1371/journal.pone.0082985	2013
	Alleviation of high fat diet-induced obesity by oligofructose in gnotobiotic mice is independent of presence of Bifidobacterium longum.	Woting A, Pfeiffer N, Hanske L, Loh G, Klaus S, Blaut M.	Mol Nutr Food Res	10.1002/mnfr.201500249	2015
	Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice.	Ganesh BP, Klopfleisch R, Loh G, Blaut M.	PLoS One	10.1371/journal.pone.0074963	2013
	Analysis of the mobilization functions of the vancomycin resistance transposon Tn1549, a member of a new family of conjugative elements.	Tsvetkova K, Marvaud JC, Lambert T.	J Bacteriol	10.1128/jb.00680-09	2010
Genetics	FSL J1-208, a virulent uncommon phylogenetic lineage IV Listeria monocytogenes strain with a small chromosome size and a putative virulence plasmid carrying internalin-like genes.	den Bakker HC, Bowen BM, Rodriguez-Rivera LD, Wiedmann M.	Appl Environ Microbiol	10.1128/aem.06969-11	2012
	Coculture of Bifidobacterium bifidum G9-1 With Butyrate-Producing Bacteria Promotes Butyrate Production.	Yokota H, Tanaka Y, Ohno H.	Microbiol Immunol	10.1111/1348-0421.13224	2025
	Heterologous Expression and Characterization of Cellouronate (beta-1,4-Glucuronan) Lyase from a Human Intestinal Bacterium Bacteroides luhongzhouii.	Tanaka Y, Matsumura K, Ariga M, Konno N, Ogata M, Habu N.	J Appl Glycosci (1999)	10.5458/jag.7203102	2025
	Clostridium butyricum-altered lung microbiome is associated with enhanced anti-influenza effects via G-protein-coupled receptor120.	Hagihara M, Yamashita M, Ariyoshi T, Minemura A, Yoshida C, Higashi S, Oka K, Takahashi M, Ota A, Maenaka A, Iwasaki K, Hirai J, Shibata Y, Umemura T, Mori T, Kato H, Asai N, Mikamo H.	iScience	10.1016/j.isci.2025.113502	2025
Metabolism	Linear and branched beta-Glucans degrading enzymes from versatile Bacteroides uniformis JCM 13288^T and their roles in cooperation with gut bacteria.	Singh RP, Rajarammohan S, Thakur R, Hassan M.	Gut Microbes	10.1080/19490976.2020.1826761	2020
Metabolism	Characterization of fructooligosaccharide metabolism and fructooligosaccharide-degrading enzymes in human commensal butyrate producers.	Tanno H, Fujii T, Hirano K, Maeno S, Tonozuka T, Sakamoto M, Ohkuma M, Tochio T, Endo A.	Gut Microbes	10.1080/19490976.2020.1869503	2021
Genetics	Complete Genome Sequence of Anaerostipes caccae Strain L1-92(T), a Butyrate-Producing Bacterium Isolated from Human Feces.	Morinaga K, Kusada H, Watanabe M, Tamaki H	Microbiol Resour Announc	10.1128/MRA.00056-21	2021
Metabolism	Lactate- and acetate-based cross-feeding interactions between selected strains of lactobacilli, bifidobacteria and colon bacteria in the presence of inulin-type fructans.	Moens F, Verce M, De Vuyst L	Int J Food Microbiol	10.1016/j.ijfoodmicro.2016.10.019	2016
Phylogeny	Anaerostipes hadrus comb. nov., a dominant species within the human colonic microbiota; reclassification of Eubacterium hadrum Moore et al. 1976.	Allen-Vercoe E, Daigneault M, White A, Panaccione R, Duncan SH, Flint HJ, O'Neal L, Lawson PA	Anaerobe	10.1016/j.anaerobe.2012.09.002	2012
Metabolism	In vitro kinetics of prebiotic inulin-type fructan fermentation by butyrate-producing colon bacteria: implementation of online gas chromatography for quantitative analysis of carbon dioxide and hydrogen gas production.	Falony G, Verschaeren A, De Bruycker F, De Preter V, Verbeke K, Leroy F, De Vuyst L	Appl Environ Microbiol	10.1128/AEM.00876-09	2009
Metabolism	Cross-feeding between Bifidobacterium longum BB536 and acetate-converting, butyrate-producing colon bacteria during growth on oligofructose.	Falony G, Vlachou A, Verbrugghe K, De Vuyst L	Appl Environ Microbiol	10.1128/AEM.01296-06	2006
Metabolism	Two routes of metabolic cross-feeding between Bifidobacterium adolescentis and butyrate-producing anaerobes from the human gut.	Belenguer A, Duncan SH, Calder AG, Holtrop G, Louis P, Lobley GE, Flint HJ	Appl Environ Microbiol	10.1128/AEM.72.5.3593-3599.2006	2006
	Fusimonas intestini gen. nov., sp. nov., a novel intestinal bacterium of the family Lachnospiraceae associated with diabetes in mice.	Kusada H, Kameyama K, Meng XY, Kamagata Y, Tamaki H.	Sci Rep	10.1038/s41598-017-18122-2	2017
Phylogeny	Anaerostipes hominis sp. nov., a novel butyrate-producing bacteria isolated from faeces of a patient with Crohn's disease.	Lee JY, Kang W, Shin NR, Hyun DW, Kim PS, Kim HS, Lee JY, Tak EJ, Sung H, Bae JW.	Int J Syst Evol Microbiol	10.1099/ijsem.0.005129	2021
Phylogeny	Description of Anaerostipes faecalis sp. nov., a new segmented filamentous bacterium isolated from swine faeces.	Choi SH, Choi JY, Park JE, Kim JS, Kang SW, Lee J, Lee MK, Lee JS, Lee JH, Jung H, Hur TY, Kim HB, Lee JH, Kim JK, Hong Y, Park SH	Antonie Van Leeuwenhoek	10.1007/s10482-021-01646-z	2021
Phylogeny	Anaerostipes rhamnosivorans sp. nov., a human intestinal, butyrate-forming bacterium.	Bui TPN, de Vos WM, Plugge CM	Int J Syst Evol Microbiol	10.1099/ijs.0.055061-0	2013
Phylogeny	Anaerostipes butyraticus sp. nov., an anaerobic, butyrate-producing bacterium from Clostridium cluster XIVa isolated from broiler chicken caecal content, and emended description of the genus Anaerostipes.	Eeckhaut V, Van Immerseel F, Pasmans F, De Brandt E, Haesebrouck F, Ducatelle R, Vandamme P	Int J Syst Evol Microbiol	10.1099/ijs.0.015289-0	2009
Phylogeny	Anaerostipes caccae gen. nov., sp. nov., a new saccharolytic, acetate-utilising, butyrate-producing bacterium from human faeces.	Schwiertz A, Hold GL, Duncan SH, Gruhl B, Collins MD, Lawson PA, Flint HJ, Blaut M	Syst Appl Microbiol	10.1078/0723-2020-00096	2002

References

#5469	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 14662
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#34329	; Curators of the CIP;
#57715	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 47493
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68380	Automatically annotated from API rID32A .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#117086	Collection of Institut Pasteur ; Curators of the CIP; CIP 108612
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Anaerostipes caccae (DSM 14662, CIP 108612, NCIMB 13811)

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Genome browser: GCA_014131675

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