Helicobacter mastomyrinus (DSM 22886, ATCC BAA-1046, CCUG 52417)

Name: Helicobacter mastomyrinus (DSM 22886, ATCC BAA-1046, CCUG 52417)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6108

Type strain

Culture col. no. DSM 22886 ATCC BAA-1046 CCUG 52417 MIT 97-5574

NCBI tax ID(s) 287948

Special Collections DSMZ CCUG

History DSMZ <- CCUG; CCUG 52417 <- Z. Shen, Massachusetts Inst. Technology (MIT), Cambridge, USA; <- S. Xu, Massachusetts Inst. Technology (MIT), Cambridge, USA; MIT 97-5574

Links

Helicobacter mastomyrinus DSM 22886 is an anaerobe bacterium that was isolated from liver or cecum of the African rodent Mastomys natalensis.

anaerobe 16S sequence Bacteria

Name and taxonomic classification

SI-ID 297225

ATCC BAA-1046,CCUG 52417,DSM 22886

@ref 20215

Last LPSN update 2026-05-29 08:26:19

Domain Bacteria

Phylum Pseudomonadota

Class Epsilonproteobacteria

Order Campylobacterales

Family Helicobacteraceae

Genus Helicobacter

Species Helicobacter mastomyrinus

Full scientific name Helicobacter mastomyrinus Shen et al. 2006

Morphology

Colony morphology

16601

Incubation period2-3 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
16601	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)		Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base

Culture temp

@ref	Growth	Type	Temperature (°C)
16601	positive	growth	37
59541	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
16601	anaerobe
59541	microaerophile

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68373	30089 ChEBI	acetate	-	assimilation	from API CAM
68373	16947 ChEBI	citrate	-	assimilation	from API CAM
68373	25115 ChEBI	malate	-	assimilation	from API CAM
68373	17272 ChEBI	propionate	-	assimilation	from API CAM
68373	30031 ChEBI	succinate	-	assimilation	from API CAM
68373	78019 ChEBI	triphenyltetrazolium chloride	-	reduction	from API CAM
68373	16199 ChEBI	urea	+	hydrolysis	from API CAM

Antibiotic resistance

@ref	ChEBI	Metabolite	Sensitivity conc.
68373	474053	cefazolin	224 µg	from API CAM
68373	48923	erythromycin	14 µg	from API CAM
68373	100147	nalidixic acid	84 µg	from API CAM

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68373	16136 ChEBI	hydrogen sulfide		from API CAM

Enzymes

@ref	Value	Activity	Ec
16601	catalase	+	1.11.1.6
68373	catalase	+	1.11.1.6	from API CAM
16601	cytochrome-c oxidase	+	1.9.3.1
68373	esterase	-		from API CAM
68373	gamma-glutamyltransferase	-	2.3.2.2	from API CAM
68373	L-arginine arylamidase	-		from API CAM
68373	L-aspartate arylamidase	-	3.4.11.21	from API CAM
68373	pyrrolidonyl arylamidase	-	3.4.19.3	from API CAM
68373	urease	+	3.5.1.5	from API CAM

API CAM

@ref	URE	Reduction of nitrateNIT	EsteraseEST	HIP	GGT	TTC	PYRA	L-arginine arylamidaseArgA	L-aspartic acid arylamidaseAspA	PAL	H2S productionH2S	GLU	SUT	NAL	CFZ	ACE	PROP	MLT	CIT	Erythromycin resistance (+) sensitivity (-)ERO	CAT
16601	+	+	-	+	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	+
16601	+	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	not determinedn.d.
16601	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
16601	+	+	-	-	-	-	-	-	-	+	-	+	-	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Muridae (Mouse/Rat)
#Host Body-Site	#Gastrointestinal tract	#Large intestine
#Host Body-Site	#Organ	#Liver

Isolation

@ref	Sample type	Sampling date	Geographic location	Country	Country ISO 3 Code	Continent	Host species
16601	liver or cecum of the African rodent Mastomys natalensis						Mastomys natalensis
59541	Mastomys liver or cecum (Mastomys natalensis)	1997-03-13	MA,Cambridge	USA	USA	North America

Taxonmaps

69479

Global distribution of 16S sequence AY742307 (>99% sequence identity) for Helicobacter mastomyrinus subclade from Microbeatlas

Aquatic Samples	0
Soil Samples	3
Animal Samples	844
Plant Samples	1
Total Samples	848

Interaction and safety

Risk assessment

@ref	Pathogenicity animal	Biosafety level	Biosafety level comment
16601	yes, in single cases	1	Risk group (German classification) According to TRBA 466

Sequence information

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
16601	Helicobacter mastomyrinus 16S ribosomal RNA gene, partial sequence	AY742307	1760		287948

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Phylogeny	Diagnosis of Genus Helicobacter through a hemi-nested PCR assay of 16S rRNA.	Qin H, Tang G, Yi P, Pan X, Huang H, Chang R, Shi Z, Ashraf MA.	Saudi Pharm J	10.1016/j.jsps.2016.04.015	2016
Genetics	Genome and pathogenicity analysis of Helicobacter mastomyrinus isolated from mice.	Liqi Z, Yuanyuan L, Linghan Y, Jun Y, Tao W, Quan Z.	Arch Microbiol	10.1007/s00203-025-04254-x	2025
	Institutional Cost Savings and Improved Pathogen Detection by Replacing Sentinel Mice with Environmental Soiled Bedding Health Monitoring Methods.	Tu-Wood ML, Hart ML, Livingston RS, Donovan KM, Hansen SA.	J Am Assoc Lab Anim Sci	10.30802/aalas-jaalas-25-087	2025
	Helicobacter mastomyrinus infection induces autoimmune hepatitis in mice.	Zhu L, Liang Y, Yang L, Yang Q, Yin J, Wang T, Xu X, Zhang Q.	J Transl Autoimmun	10.1016/j.jtauto.2025.100275	2025
	Non-Invasive Analyses of Altered Schaedler Flora in C57Bl/6J and Balb/c Mice to Monitor Hygiene Status of a Housing Facility.	Nistelberger R, Gibler P, Barones L, Absenger A, Kral-Pointner JB, Salzmann M, Hartmann B, Podesser BK, Hohensinner PJ, Plasenzotti R.	Animals (Basel)	10.3390/ani15121725	2025
	Rodent Pathogen Detection via Testing of Soiled Nesting Material.	Kurtz DM, Angermeier L, Chisolm M, Johnston M, Whiteside T, Locklear J, Shi M.	J Am Assoc Lab Anim Sci	10.30802/aalas-jaalas-25-037	2025
Genetics	Effect of minocycline, methyl prednisolone, or combination treatment on the colonic bacterial population in a state of colonic inflammation using the murine dextran sulfate sodium model.	Khajah MA, Hawai S.	Microb Cell Fact	10.1186/s12934-023-02242-8	2023
Enzymology	Assessing the Biosecurity Risk of Footwear as a Fomite for Transmission of Adventitious Infectious Agents to Mice	Palillo M, Mishkin N, Atmane M, Palillo J, Carrasco S, Woods C, Henderson K, Lipman N, Ricart Arbona R.	J Am Assoc Lab Anim Sci		2025
	Burrowing Behavior as Robust Parameter for Early Humane Endpoint Determination in Murine Models for Pancreatic Cancer.	Brandstetter J, Hoffmann L, Koopmann I, Schreiber T, Schulz B, Rosshart SP, Zechner D, Vollmar B, Kumstel S.	Animals (Basel)	10.3390/ani15091241	2025
	Electroacupuncture relieves portal hypertension by improving vascular angiogenesis and linking gut microbiota in bile duct ligation rats.	Huang PY, Liu HM, Ko YR, Chang ZY, Lee TY.	Front Microbiol	10.3389/fmicb.2023.1207137	2023
	Supplemental Effects of Functional Oils on the Modulation of Mucosa-Associated Microbiota, Intestinal Health, and Growth Performance of Nursery Pigs.	Moita VHC, Duarte ME, da Silva SN, Kim SW.	Animals (Basel)	10.3390/ani11061591	2021
	Significance of Mucosa-Associated Microbiota and Its Impacts on Intestinal Health of Pigs Challenged with F18⁺E. coli.	Duarte ME, Kim SW.	Pathogens	10.3390/pathogens11050589	2022
	The Neuroprotective Effects of Spray-Dried Porcine Plasma Supplementation Involve the Microbiota-Gut-Brain Axis.	Rosell-Cardona C, Amat C, Grinan-Ferre C, Polo J, Pallas M, Perez-Bosque A, Moreto M, Miro L.	Nutrients	10.3390/nu14112211	2022
Pathogenicity	Secoisolariciresinol diglucoside attenuates neuroinflammation and cognitive impairment in female Alzheimer's disease mice via modulating gut microbiota metabolism and GPER/CREB/BDNF pathway.	Jia M, Ning F, Wen J, Wang X, Chen J, Hu J, Chen X, Liu Z.	J Neuroinflammation	10.1186/s12974-024-03195-4	2024
Pathogenicity	Impacts of weaning weights and mycotoxin challenges on jejunal mucosa-associated microbiota, intestinal and systemic health, and growth performance of nursery pigs.	Holanda DM, Kim SW.	J Anim Sci Biotechnol	10.1186/s40104-022-00691-6	2022
	Postbiotic effects of Lactobacillus fermentate on intestinal health, mucosa-associated microbiota, and growth efficiency of nursery pigs challenged with F18+Escherichia coli.	Xu X, Duarte ME, Kim SW.	J Anim Sci	10.1093/jas/skac210	2022
Genetics	Whole-Genome Sequencing and Bioinformatics as Pertinent Tools to Support Helicobacteracae Taxonomy, Based on Three Strains Suspected to Belong to Novel Helicobacter Species.	Berthenet E, Benejat L, Menard A, Varon C, Lacomme S, Gontier E, Raymond J, Boussaba O, Toulza O, Ducournau A, Buissonniere A, Giese A, Megraud F, Bessede E, Jehanne Q, Lehours P.	Front Microbiol	10.3389/fmicb.2019.02820	2019
Phylogeny	A novel enterohepatic Helicobacter species 'Helicobacter mastomyrinus' isolated from the liver and intestine of rodents.	Shen Z, Xu S, Dewhirst FE, Paster BJ, Pena JA, Modlin IM, Kidd M, Fox JG.	Helicobacter	10.1111/j.1523-5378.2005.00292.x	2005
Phylogeny	Composition of gut and oropharynx bacterial communities in Rattus norvegicus and Suncus murinus in China.	He WQ, Xiong YQ, Ge J, Chen YX, Chen XJ, Zhong XS, Ou ZJ, Gao YH, Cheng MJ, Mo Y, Wen YQ, Qiu M, Huo ST, Chen SW, Zheng XY, He H, Li YZ, You FF, Zhang MY, Chen Q.	BMC Vet Res	10.1186/s12917-020-02619-6	2020
	The Role of Ames Dwarfism and Calorie Restriction on Gut Microbiota.	Wiesenborn DS, Galvez EJC, Spinel L, Victoria B, Allen B, Schneider A, Gesing A, Al-Regaiey KA, Strowig T, Schafer KH, Masternak MM.	J Gerontol A Biol Sci Med Sci	10.1093/gerona/glz236	2020
	Modulation of jejunal mucosa-associated microbiota in relation to intestinal health and nutrient digestibility in pigs by supplementation of beta-glucanase to corn-soybean meal-based diets with xylanase.	Duarte ME, Sparks C, Kim SW.	J Anim Sci	10.1093/jas/skab190	2021
Metabolism	Ulcerative typhlocolitis associated with Helicobacter mastomyrinus in telomerase-deficient mice.	Eaton KA, Opp JS, Gray BM, Bergin IL, Young VB.	Vet Pathol	10.1177/0300985810383876	2011
	Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis.	Beyaz S, Chung C, Mou H, Bauer-Rowe KE, Xifaras ME, Ergin I, Dohnalova L, Biton M, Shekhar K, Eskiocak O, Papciak K, Ozler K, Almeqdadi M, Yueh B, Fein M, Annamalai D, Valle-Encinas E, Erdemir A, Dogum K, Shah V, Alici-Garipcan A, Meyer HV, Ozata DM, Elinav E, Kucukural A, Kumar P, McAleer JP, Fox JG, Thaiss CA, Regev A, Roper J, Orkin SH, Yilmaz OH.	Cell Stem Cell	10.1016/j.stem.2021.08.007	2021
	Dual epithelial and immune cell function of Dvl1 regulates gut microbiota composition and intestinal homeostasis.	Belinson H, Savage AK, Fadrosh D, Kuo YM, Lin D, Valladares R, Nusse Y, Wynshaw-Boris A, Lynch SV, Locksley RM, Klein OD.	JCI Insight	10.1172/jci.insight.85395	2016
Metabolism	Giardia Infection of the Small Intestine Induces Chronic Colitis in Genetically Susceptible Hosts.	Dann SM, Le CHY, Hanson EM, Ross MC, Eckmann L.	J Immunol	10.4049/jimmunol.1700824	2018
	Limiting oxidative DNA damage reduces microbe-induced colitis-associated colorectal cancer.	Irrazabal T, Thakur BK, Kang M, Malaise Y, Streutker C, Wong EOY, Copeland J, Gryfe R, Guttman DS, Navarre WW, Martin A.	Nat Commun	10.1038/s41467-020-15549-6	2020
Pathogenicity	Efficacy of a Yeast Cell Wall Extract to Mitigate the Effect of Naturally Co-Occurring Mycotoxins Contaminating Feed Ingredients Fed to Young Pigs: Impact on Gut Health, Microbiome, and Growth.	Kim SW, Holanda DM, Gao X, Park I, Yiannikouris A.	Toxins (Basel)	10.3390/toxins11110633	2019
Metabolism	Transgenic mice expressing tunable levels of DUX4 develop characteristic facioscapulohumeral muscular dystrophy-like pathophysiology ranging in severity.	Jones TI, Chew GL, Barraza-Flores P, Schreier S, Ramirez M, Wuebbles RD, Burkin DJ, Bradley RK, Jones PL.	Skelet Muscle	10.1186/s13395-020-00227-4	2020
	Persistent Helicobacter pullorum colonization in C57BL/6NTac mice: a new mouse model for an emerging zoonosis.	Turk ML, Cacioppo LD, Ge Z, Shen Z, Whary MT, Parry N, Boutin SR, Klein HJ, Fox JG.	J Med Microbiol	10.1099/jmm.0.040055-0	2012
	Dose-dependent incidence of hepatic tumors in adult mice following perinatal exposure to bisphenol A.	Weinhouse C, Anderson OS, Bergin IL, Vandenbergh DJ, Gyekis JP, Dingman MA, Yang J, Dolinoy DC.	Environ Health Perspect	10.1289/ehp.1307449	2014
Pathogenicity	Bacterial toxin modulation of the eukaryotic cell cycle: are all cytolethal distending toxins created equally?	Gargi A, Reno M, Blanke SR.	Front Cell Infect Microbiol	10.3389/fcimb.2012.00124	2012
Phylogeny	Helicobacter apri sp. nov., isolated from wild boars.	Zanoni RG, Piva S, Florio D, Bassi P, Mion D, Cnockaert M, Luchetti A, Vandamme P.	Int J Syst Evol Microbiol	10.1099/ijsem.0.001071	2016

References

#16601	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 22886
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#59541	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 52417
#68373	Automatically annotated from API CAM .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Helicobacter mastomyrinus (DSM 22886, ATCC BAA-1046, CCUG 52417)

Name and taxonomic classification

Morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Metabolite utilization

Antibiotic resistance

Metabolite production

Enzymes

API CAM

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

16S sequences

Genome-based predictions

Literature

Literature

References

BacDive

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