Helicobacter pylori (CCUG 15815, LMG 7540, CIP 103995)

Name: Helicobacter pylori (CCUG 15815, LMG 7540, CIP 103995)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6102

Type strain

Strain Designation RPH 13487

Culture col. no. CCUG 15815 LMG 7540 CIP 103995 DSM 21031 ATCC 43504 9 more

NCBI tax ID(s) 102618 210

Special Collections DSMZ CCUG JCM CIP Literature strains

History <- NCTC; NCTC 11637 <- C. S. Goodwin and D. I. Annear; CIP 103995 <-- CCUG 17874 <-- E. Blincow and C. S. Goodwin K0045659.

Links

Helicobacter pylori RPH 13487 is a microaerophile, mesophilic, Gram-negative prokaryote that was isolated from endoscopic biopsy specimen of human gastric mucosa.

Gram-negative rod-shaped microaerophile mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 10524

LMG 18041,CCUG 15815 B,CCUG 17874,CIP 103995,LMG 18045,LMG 7539,LMG 7540,LMG 19449,ATCC 43504,CCUG 39500,NCTC 11637,JCM 7653,CCUG 15815 A,CCUG 15815,DSM 4867,KCTC 2948,KCTC 12083,CCUG 41351,JCM 12093,BCRC 15415,CCRC 15415,VTT E-021812,DSM 21031

@ref 20215

Last LPSN update 2026-02-09 11:19:07

Domain Bacteria

Phylum Pseudomonadota

Class Epsilonproteobacteria

Order Campylobacterales

Family Helicobacteraceae

Genus Helicobacter

Species Helicobacter pylori

Full scientific name Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989

Synonyms (3)

Helicobacter nemestrinae
Campylobacter pylori
Campylobacter pyloridis

BacDive ID	Other strains from **Helicobacter pylori** (69)	Type strain
6099	H. pylori T81213-NTB, T81123-NTB, DSM 7492, ATCC 49396, ...
6100	H. pylori Göteborg 113, DSM 9691, CCUG 21658
6101	H. pylori RPH 13491, DSM 10242, NCTC 11638, CCUG 17875, ...
24099	H. pylori ASTRA J99, J99, DSM 28160, CCUG 47164, ATCC ...
135116	H. pylori 85P, CIP 104086, JCM 12095
135395	H. pylori N6, CIP 104085, JCM 12094
135934	H. pylori 26695, CIP 106780, JCM 12097
137187	H. pylori CGLO-1, CIP 101260, JCM 12092, CCUG 18943, ...
142935	H. pylori CCUG 15815 B
142936	H. pylori CCUG 15816 B, LMG 8773
142937	H. pylori CCUG 15817
142938	H. pylori CCUG 15818, ATCC 43629, NCTC 11639, LMG 8927, ...
143086	H. pylori CCUG 17135, CCUG 17073
143299	H. pylori CCUG 18295
143328	H. pylori CCUG 18430
143425	H. pylori CCUG 19087
143430	H. pylori CCUG 19104
143431	H. pylori CCUG 19106, LMG 8775
143432	H. pylori CCUG 19107
143433	H. pylori CCUG 19110
143627	H. pylori CCUG 20649
143831	H. pylori CCUG 21365
143840	H. pylori CCUG 21460
143952	H. pylori CCUG 22032
143953	H. pylori CCUG 22035
143954	H. pylori CCUG 22036
143955	H. pylori CCUG 22037
143964	H. pylori CCUG 22110
143980	H. pylori CCUG 22225, LMG 8164
144370	H. pylori CCUG 24780
146346	H. pylori CCUG 30985
146347	H. pylori CCUG 30986
146348	H. pylori CCUG 30987
146349	H. pylori CCUG 30988
146350	H. pylori CCUG 30989
146351	H. pylori CCUG 30990
146352	H. pylori CCUG 30992
146353	H. pylori CCUG 30993
146354	H. pylori CCUG 30994
146462	H. pylori CCUG 31209
148598	H. pylori CCUG 35689
148752	H. pylori CCUG 35899
148764	H. pylori CCUG 35914
149009	H. pylori CCUG 36718
149010	H. pylori CCUG 36719
149969	H. pylori CCUG 38770
149970	H. pylori CCUG 38771
149971	H. pylori CCUG 38772
150213	H. pylori CCUG 39297
150435	H. pylori CCUG 39924
150675	H. pylori CCUG 41936, ATCC 700392, NCTC 12455
152974	H. pylori CCUG 48166
156766	H. pylori CCUG 64957
157640	H. pylori 82894, DSM 105195
157641	H. pylori 85107, DSM 105196
157642	H. pylori 87041, DSM 105197
157643	H. pylori 86298, DSM 105198
157644	H. pylori 85369, DSM 105199
157645	H. pylori 85592, DSM 105200
157646	H. pylori 86153, DSM 105260
157647	H. pylori 83321, DSM 105261
157648	H. pylori G27, DSM 105292
157649	H. pylori J166, DSM 105293
157650	H. pylori PMSS1, DSM 105294
157651	H. pylori 2808, DSM 105296
157652	H. pylori Sydney strain, SS1, DSM 105297
157653	H. pylori Tx30, DSM 105400, ATCC 51932
157654	H. pylori 85593, DSM 105470
157655	H. pylori 85866, DSM 105471

Morphology

Cell morphology

@ref	Gram stain	Cell length	Cell width	Cell shape	Flagellum arrangement	Confidence
22920	negative	2.5-5 µm	0.5-1 µm	rod-shaped	polar
125438	negative					98.841
125439	negative					98.5

Colony morphology

15441

Incubation period1-2 days

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
22920	Brain heart infusion
15441	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
41863	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
15441	positive	growth	37	mesophilic
22920	positive	growth	37	mesophilic
41863	positive	growth	37	mesophilic
46705	positive	growth	37	mesophilic
67770	positive	growth	37	mesophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
46705	microaerophile
125439	microaerophile	93.2

Spore formation

@ref	Spore formation	Confidence
125438		95.38
125439		98.3

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
22920	606565 ChEBI	hippurate	-	hydrolysis
22920	17632 ChEBI	nitrate	-	reduction
68373	17272 ChEBI	propionate	-	assimilation	from API CAM
22920	16199 ChEBI	urea	+	hydrolysis
68373	16199 ChEBI	urea	+	hydrolysis	from API CAM

Antibiotic resistance

@ref	ChEBI	Metabolite	Sensitivity conc.
68373	474053	cefazolin	224 µg	from API CAM
68373	48923	erythromycin	14 µg	from API CAM
68373	100147	nalidixic acid	84 µg	from API CAM

Metabolite production

@ref	Chebi-ID	Metabolite	Production
22920	16136 ChEBI	hydrogen sulfide
68373	16136 ChEBI	hydrogen sulfide		from API CAM

Enzymes

@ref	Value	Activity	Ec
22920	alkaline phosphatase	-	3.1.3.1
68373	alkaline phosphatase	+	3.1.3.1	from API CAM
22920	catalase	+	1.11.1.6
15441	catalase	+	1.11.1.6
68373	catalase	+	1.11.1.6	from API CAM
22920	cytochrome oxidase	+	1.9.3.1
15441	cytochrome-c oxidase	+	1.9.3.1
68373	gamma-glutamyltransferase	+	2.3.2.2	from API CAM
68373	L-arginine arylamidase	-		from API CAM
68373	L-aspartate arylamidase	-	3.4.11.21	from API CAM
22920	leucine arylamidase	+/-	3.4.11.1
22920	urease	+	3.5.1.5
68373	urease	+	3.5.1.5	from API CAM

Fatty acid profile

Metadata FA analysis

@ref

46705

Fatty acid	Percentage	ECL
C14:0	50.9	14
C19:0 CYCLO ω8c	19.7	18.9
C18:1 ω7c /12t/9t	6.4	17.824
C16:0 3OH	5.5	17.52
C18:0	4.6	18
C18:0 3OH	3.9	19.551
C16:0	2	16
C18:2 ω6,9c/C18:0 ANTE	1.1	17.724
C15:0	1.1	15
unknown 14.966	1.1	14.966
C13:1 at 12-13	0.9	12.931
C17:0 3OH	0.8	18.535
C12:0	0.6	12
C13:0 ISO 2OH	0.5	13.814
C19:0	0.5	19
C13:0	0.5	13

API CAM

@ref	URE	Reduction of nitrateNIT	EsteraseEST	HIP	GGT	TTC	PYRA	L-arginine arylamidaseArgA	L-aspartic acid arylamidaseAspA	PAL	H2S productionH2S	GLU	SUT	NAL	CFZ	ACE	PROP	MLT	CIT	Erythromycin resistance (+) sensitivity (-)ERO	CAT
15441	+	+	+	-	+	+	+/-	-	-	+	-	+	+/-	-	-	+	-	+/-	+	-	+
15441	+	-	-	-	+	+/-	-	-	-	+	-	+/-	-	-	-	-	-	-	-	-	+
15441	+	-	-	+	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	+/-	-	-	-	-	-	-	-	+
15441	+	-	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
15441	+	-	-	-	+	-	+/-	-	-	+	-	-	-	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Patient	#Biopsy
#Infection	#Patient	#Specimen
#Host	#Human	-
#Host Body-Site	#Gastrointestinal tract	#Stomach

Isolation

@ref	Sample type	Sampling date	Geographic location	Country	Country ISO 3 Code	Continent
15441	endoscopic biopsy specimen of human gastric mucosa			Australia	AUS	Australia and Oceania
46705	Human gastric biopsy	1982-05-05	Perth	Australia	AUS	Australia and Oceania
67770	Endoscopic biopsy specimen of human gastric mucosa		Royal Perth Hospital	Australia	AUS	Australia and Oceania

Taxonmaps

69479

Global distribution of 16S sequence Z25741 (>99% sequence identity) for Helicobacter pylori subclade from Microbeatlas

Aquatic Samples	829
Soil Samples	670
Animal Samples	16307
Plant Samples	278
Total Samples	18084

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
15441	2	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM305066v1 assembly for Helicobacter pylori FDAARGOS_298	complete	GCA_003050665	210.4220	2859855209	210	99.18
66792	35377_D02 assembly for Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093	complete	GCA_900478295	102618.7	2896621630	102618	98.88
66792	HP_PMSS1_01 assembly for Helicobacter pylori PMSS1	complete	GCA_004295545	210.5631	2879776430	210	98.87
66792	HPATCC43504_01 assembly for Helicobacter pylori ATCC 43504	complete	GCA_004295525	210.5630		210	98.53
67770	ASM25884v1 assembly for Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 = JCM 12093	contig	GCA_000258845	102618.3	2537562118	102618	44.59
66792	ASM1465443v1 assembly for Helicobacter pylori JCM 12093	scaffold	GCA_014654435	210.7428		210	39.41
67770	ASM220646v2 assembly for Helicobacter pylori FDAARGOS_299	contig	GCA_002206465	210.2680		210	32.66
66792	ASM131276v1 assembly for Helicobacter pylori JCM 12093	contig	GCA_001312765	1300157.3	2734481914	102618	9.68

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Helicobacter pylori 16S ribosomal RNA gene, partial sequence	AF302106	1445	210
20218	Helicobacter pylori (ATCC 43504) partial 16S ribosomal RNA	M88157	1450	210
20218	Helicobacter pylori isolate ATCC 43504 16S rRNA gene	U01330	1503	210
20218	H.pylori gene for 16S ribosomal RNA (partial)	Z25741	1454	102618
15441	Helicobacter pylori strain ATCC 43504 16S ribosomal RNA, partial sequence	NR_044761	1503	210
67770	Helicobacter pylori JCM 12093 gene for 16S ribosomal RNA, partial sequence	LC507447	1426	210
124043	Helicobacter pylori strain ATCC 43504 16S ribosomal RNA gene, partial sequence.	MN326691	1406	210
124043	Helicobacter pylori strain ATCC 43504 16S ribosomal RNA gene, partial sequence.	PQ482071	1503	210

GC content

@ref	GC-content (mol%)	Method
22920	37.1
67770	37.1	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Helicobacter pylori ATCC 43504
NCBI: GCA_004295525

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	microaerophile	93.20	no
125439	gram_stain	BacteriaNetⓘ	negative	98.50	no
125439	motility	BacteriaNetⓘ	no	70.90	no
125439	spore_formation	BacteriaNetⓘ	no	98.30	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Helicobacter pylori NCTC 11637 = CCUG 17874 = ATCC 43504 NCTC 11637
NCBI: GCA_900478295.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	98.84	yes
125438	anaerobic	anaerobicⓘ	no	78.69	no
125438	aerobic	aerobicⓘ	no	91.07	yes
125438	spore-forming	spore-formingⓘ	no	95.38	no
125438	thermophilic	thermophileⓘ	no	88.12	no
125438	flagellated	motile2+ⓘ	no	52.42	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Therapeutic Potential of Ozonated Ocimum basilicum L. from Saudi Arabia: Phytochemical Characterization and Enhanced Bioactivities	Qanash H, Alsalamah S, Bazaid A, Alghonaim M, Duhduh A, Hudani I.	Pharmaceuticals (Basel)		2025
	Helicobacter pylori, Protected from Antibiotics and Stresses Inside Candida albicans Vacuoles, Cause Gastritis in Mice.	Hiengrach P, Panpetch W, Chindamporn A, Leelahavanichkul A.	Int J Mol Sci	10.3390/ijms23158568	2022
	Detection of Helicobacter pylori by using the polymerase chain reaction.	Valentine JL, Arthur RR, Mobley HL, Dick JD.	J Clin Microbiol	10.1128/jcm.29.4.689-695.1991	1991
	Helicobacter pylori. Its role in the pathogenesis of peptic ulcer disease in a new animal model.	Ross JS, Bui HX, del Rosario A, Sonbati H, George M, Lee CY.	Am J Pathol		1992
Enzymology	Characterization and presumptive identification of Helicobacter pylori isolates from rhesus monkeys.	Drazek ES, Dubois A, Holmes RK.	J Clin Microbiol	10.1128/jcm.32.7.1799-1804.1994	1994
Pathogenicity	Utilization of time-kill kinetic methodologies for assessing the bactericidal activities of ampicillin and bismuth, alone and in combination, against Helicobacter pylori in stationary and logarithmic growth phases.	Coudron PE, Stratton CW.	Antimicrob Agents Chemother	10.1128/aac.39.1.66	1995
	Helicobacter pylori in Dyspepsia - Antibiotic Sensitivity and Virulence Patterns.	Misra RN, Bhagat M, Ahmed N.	Med J Armed Forces India	10.1016/s0377-1237(06)80147-4	2006
Pathogenicity	In vitro synergy testing of clarithromycin and 14-hydroxyclarithromycin with amoxicillin or bismuth subsalicylate against Helicobacter pylori.	Meyer JM, Ryu S, Pendland SL, Danziger LH.	Antimicrob Agents Chemother	10.1128/aac.41.7.1607	1997
Enzymology	Oligonucleotide probe for detection and identification of Campylobacter pylori.	Morotomi M, Hoshina S, Green P, Neu HC, LoGerfo P, Watanabe I, Mutai M, Weinstein IB.	J Clin Microbiol	10.1128/jcm.27.12.2652-2655.1989	1989
Pathogenicity	Bisulfite or sulfite inhibits growth of Helicobacter pylori.	Hawrylik SJ, Wasilko DJ, Haskell SL, Gootz TD, Lee SE.	J Clin Microbiol	10.1128/jcm.32.3.790-792.1994	1994
	Evidence of novel pathogenic pathways for the formation of antigastric autoantibodies in Helicobacter pylori gastritis.	Faller G, Steininger H, Appelmelk B, Kirchner T.	J Clin Pathol	10.1136/jcp.51.3.244	1998
Cultivation	Evaluation of techniques for isolation, subcultivation, and preservation of Helicobacter pylori.	Ansorg R, Von Recklinghausen G, Pomarius R, Schmid EN.	J Clin Microbiol	10.1128/jcm.29.1.51-53.1991	1991
	The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence.	Solnick JV, Hansen LM, Syvanen M.	J Bacteriol	10.1128/jb.179.19.6196-6200.1997	1997
	Bacterial factors and immune pathogenesis in Helicobacter pylori infection.	Shimoyama T, Crabtree JE.	Gut	10.1136/gut.43.2008.s2	1998
Enzymology	Isolation of a Campylobacter-like organism from healthy Syrian hamsters (Mesocricetus auratus).	Stills HF, Hook RR, Kinden DA.	J Clin Microbiol	10.1128/jcm.27.11.2497-2501.1989	1989
	Seroepidemiological study of Helicobacter pylori infection in infancy.	Ashorn M, Miettinen A, Ruuska T, Laippala P, Maki M.	Arch Dis Child Fetal Neonatal Ed	10.1136/fn.74.2.f141	1996
Metabolism	Iron acquisition by Helicobacter pylori: importance of human lactoferrin.	Husson MO, Legrand D, Spik G, Leclerc H.	Infect Immun	10.1128/iai.61.6.2694-2697.1993	1993
Pathogenicity	Binding and killing of bacteria by bismuth subsalicylate.	Sox TE, Olson CA.	Antimicrob Agents Chemother	10.1128/aac.33.12.2075	1989
	Evaluation of a new immunodiagnostic assay for Helicobacter pylori antibody detection: correlation with histopathological and microbiological results.	Pronovost AD, Rose SL, Pawlak JW, Robin H, Schneider R.	J Clin Microbiol	10.1128/jcm.32.1.46-50.1994	1994
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Pathogenicity	Synthesis and antimicrobial evaluation of dirithromycin (AS-E 136; LY237216), a new macrolide antibiotic derived from erythromycin.	Counter FT, Ensminger PW, Preston DA, Wu CY, Greene JM, Felty-Duckworth AM, Paschal JW, Kirst HA.	Antimicrob Agents Chemother	10.1128/aac.35.6.1116	1991
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Metabolism	Interaction of lipopolysaccharides of Helicobacter pylori with basement membrane protein laminin.	Valkonen KH, Wadstrom T, Moran AP.	Infect Immun	10.1128/iai.62.9.3640-3648.1994	1994
	Detection of serum antibodies to CagA and VacA and of serum neutralizing activity for vacuolating cytotoxin in patients with Helicobacter pylori-induced gastritis.	Donati M, Moreno S, Storni E, Tucci A, Poli L, Mazzoni C, Varoli O, Sambri V, Farencena A, Cevenini R.	Clin Diagn Lab Immunol	10.1128/cdli.4.4.478-482.1997	1997
	cagA positive and negative Helicobacter pylori strains are simultaneously present in the stomach of most patients with non-ulcer dyspepsia: relevance to histological damage.	Figura N, Vindigni C, Covacci A, Presenti L, Burroni D, Vernillo R, Banducci T, Roviello F, Marrelli D, Biscontri M, Kristodhullu S, Gennari C, Vaira D.	Gut	10.1136/gut.42.6.772	1998
	Cytotoxin production by Campylobacter pylori strains isolated from patients with peptic ulcers and from patients with chronic gastritis only.	Figura N, Guglielmetti P, Rossolini A, Barberi A, Cusi G, Musmanno RA, Russi M, Quaranta S.	J Clin Microbiol	10.1128/jcm.27.1.225-226.1989	1989
Enzymology	Macromolecular structure and aggregation states of Helicobacter pylori urease.	Austin JW, Doig P, Stewart M, Trust TJ.	J Bacteriol	10.1128/jb.173.18.5663-5667.1991	1991
	Effect of Helicobacter pylori on gastric epithelial cell migration and proliferation in vitro: role of VacA and CagA.	Ricci V, Ciacci C, Zarrilli R, Sommi P, Tummuru MK, Del Vecchio Blanco C, Bruni CB, Cover TL, Blaser MJ, Romano M.	Infect Immun	10.1128/iai.64.7.2829-2833.1996	1996
Enzymology	Identification of Campylobacter cinaedi isolated from blood and feces of children and adult females.	Vandamme P, Falsen E, Pot B, Kersters K, De Ley J.	J Clin Microbiol	10.1128/jcm.28.5.1016-1020.1990	1990
Metabolism	High-affinity binding of the basement membrane proteins collagen type IV and laminin to the gastric pathogen Helicobacter pylori.	Trust TJ, Doig P, Emody L, Kienle Z, Wadstrom T, O'Toole P.	Infect Immun	10.1128/iai.59.12.4398-4404.1991	1991
Metabolism	Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.	Huesca M, Borgia S, Hoffman P, Lingwood CA.	Infect Immun	10.1128/iai.64.7.2643-2648.1996	1996
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	Identification, characterization, and spatial localization of two flagellin species in Helicobacter pylori flagella.	Kostrzynska M, Betts JD, Austin JW, Trust TJ.	J Bacteriol	10.1128/jb.173.3.937-946.1991	1991
Metabolism	Structure, function and localization of Helicobacter pylori urease.	Dunn BE, Phadnis SH.	Yale J Biol Med		1998
Metabolism	Sialic acids in molecular and cellular interactions.	Kelm S, Schauer R.	Int Rev Cytol	10.1016/s0074-7696(08)62127-0	1997
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	Gas-permeable lifecell tissue culture flasks give improved growth of Helicobacter pylori in a liquid medium.	Secker DA, Tompkins DS, Alderson G.	J Clin Microbiol	10.1128/jcm.29.5.1060-1061.1991	1991
Pathogenicity	DNA fingerprints of Helicobacter pylori before and after treatment with omeprazole.	Fraser AG, Bickley J, Owen RJ, Pounder RE.	J Clin Pathol	10.1136/jcp.45.12.1062	1992
Pathogenicity	Omeprazole may exert both a bacteriostatic and a bacteriocidal effect on the growth of Helicobacter pylori (NCTC 11637) in vitro by inhibiting bacterial urease activity.	Mirshahi F, Fowler G, Patel A, Shaw G.	J Clin Pathol	10.1136/jcp.51.3.220	1998
Metabolism	Binding of Helicobacter pylori to sialic acid-containing glycolipids of various origins separated on thin-layer chromatograms.	Miller-Podraza H, Milh MA, Teneberg S, Karlsson KA.	Infect Immun	10.1128/iai.65.6.2480-2482.1997	1997
Phylogeny	Ribosomal RNA gene restriction patterns of Helicobacter pylori: analysis and appraisal of Hae III digests as a molecular typing system.	Owen RJ, Hunton C, Bickley J, Moreno M, Linton D.	Epidemiol Infect		1992
	Characterization of an immunoreactive species-specific 19-kilodalton outer membrane protein from Helicobacter pylori by using a monoclonal antibody.	Drouet EB, Denoyel GA, Boude M, Wallano E, Andujar M, de Montclos HP.	J Clin Microbiol	10.1128/jcm.29.8.1620-1624.1991	1991
Pathogenicity	Bacterial activity of a new antiulcer agent, ecabet sodium, against Helicobacter pylori under acidic conditions.	Shibata K, Ito Y, Hongo A, Yasoshima A, Endo T, Ohashi M.	Antimicrob Agents Chemother	10.1128/aac.39.6.1295	1995
	Incidence of Helicobacter pylori strains activating neutrophils in patients with peptic ulcer disease.	Rautelin H, Blomberg B, Fredlund H, Jarnerot G, Danielsson D.	Gut	10.1136/gut.34.5.599	1993
Cultivation	Enhanced cultivation of Helicobacter pylori in liquid media.	Xia HX, English L, Keane CT, O'Morain CA.	J Clin Pathol	10.1136/jcp.46.8.750	1993
	Ultrastructural study of two patterns in the interaction of Helicobacter pylori with neutrophils.	Rautelin H, von Bonsdorff CH, Blomberg B, Danielsson D.	J Clin Pathol	10.1136/jcp.47.7.667	1994
Enzymology	Monoclonal antibodies against the native urease of Helicobacter pylori: synergistic inhibition of urease activity by monoclonal antibody combinations.	Nagata K, Mizuta T, Tonokatu Y, Fukuda Y, Okamura H, Hayashi T, Shimoyama T, Tamura T.	Infect Immun	10.1128/iai.60.11.4826-4831.1992	1992
	Evaluation of an immunofluorescence assay for specific detection of immunoglobulin G antibodies directed against Helicobacter pylori, and antigenic cross-reactivity between H. pylori and Campylobacter jejuni.	Faulde M, Putzker M, Mertes T, Sobe D.	J Clin Microbiol	10.1128/jcm.29.2.323-327.1991	1991
	Ribosomal RNA gene patterns of Helicobacter pylori from surgical patients with healed and recurrent peptic ulcers.	Owen RJ, Bickley J, Lastovica A, Dunn JP, Borman P, Hunton C.	Epidemiol Infect	10.1017/s0950268800049487	1992
Phylogeny	Isoelectric focusing of ureases from Campylobacter pylori and related organisms.	Tompkins DS, Millar MR, West AP.	J Clin Microbiol	10.1128/jcm.26.12.2678-2679.1988	1988
	Unusual fatty acid substitution in lipids and lipopolysaccharides of Helicobacter pylori.	Geis G, Leying H, Suerbaum S, Opferkuch W.	J Clin Microbiol	10.1128/jcm.28.5.930-932.1990	1990
Metabolism	Helicobacter pylori induced interleukin-8 expression in gastric epithelial cells is associated with CagA positive phenotype.	Crabtree JE, Covacci A, Farmery SM, Xiang Z, Tompkins DS, Perry S, Lindley IJ, Rappuoli R.	J Clin Pathol	10.1136/jcp.48.1.41	1995
	Hemagglutination activity of Campylobacter pylori.	Nakazawa T, Ishibashi M, Konishi H, Takemoto T, Shigeeda M, Kochiyama T.	Infect Immun	10.1128/iai.57.3.989-991.1989	1989
Enzymology	The characterization and pathological significance of gastric Campylobacter-like organisms in the ferret: a model for chronic gastritis?	Tompkins DS, Wyatt JI, Rathbone BJ, West AP.	Epidemiol Infect	10.1017/s0950268800054182	1988
Enzymology	Production of a conserved adhesin by the human gastroduodenal pathogen Helicobacter pylori.	Doig P, Austin JW, Kostrzynska M, Trust TJ.	J Bacteriol	10.1128/jb.174.8.2539-2547.1992	1992
Metabolism	CagA/cytotoxic strains of Helicobacter pylori and interleukin-8 in gastric epithelial cell lines.	Crabtree JE, Farmery SM, Lindley IJ, Figura N, Peichl P, Tompkins DS.	J Clin Pathol	10.1136/jcp.47.10.945	1994
	Identification of surface-exposed outer membrane antigens of Helicobacter pylori.	Doig P, Trust TJ.	Infect Immun	10.1128/iai.62.10.4526-4533.1994	1994
	Contact of lymphocytes with Helicobacter pylori augments natural killer cell activity and induces production of gamma interferon.	Tarkkanen J, Kosunen TU, Saksela E.	Infect Immun	10.1128/iai.61.7.3012-3016.1993	1993
	Prevention of Helicobacter pylori infection by lactobacilli in a gnotobiotic murine model.	Kabir AM, Aiba Y, Takagi A, Kamiya S, Miwa T, Koga Y.	Gut	10.1136/gut.41.1.49	1997
Enzymology	New plate medium for growth and detection of urease activity of Helicobacter pylori.	Cellini L, Allocati N, Piccolomini R, Di Campli E, Dainelli B.	J Clin Microbiol	10.1128/jcm.30.5.1351-1353.1992	1992
	Comparison of PCR-based restriction length polymorphism analysis of urease genes with rRNA gene profiling for monitoring Helicobacter pylori infections in patients on triple therapy.	Owen RJ, Bickley J, Hurtado A, Fraser A, Pounder RE.	J Clin Microbiol	10.1128/jcm.32.5.1203-1210.1994	1994
Pathogenicity	Evaluation of the E test for quantitative antimicrobial susceptibility testing of Helicobacter pylori.	Glupczynski Y, Labbe M, Hansen W, Crokaert F, Yourassowsky E.	J Clin Microbiol	10.1128/jcm.29.9.2072-2075.1991	1991
	Comparison of ELISA antigen preparations alone or in combination for serodiagnosing Helicobacter pylori infections.	Hirschl AM, Rathbone BJ, Wyatt JI, Berger J, Rotter ML.	J Clin Pathol	10.1136/jcp.43.6.511	1990
Cultivation	Egg yolk emulsion agar, a new medium for the cultivation of Helicobacter pylori.	Westblom TU, Madan E, Midkiff BR.	J Clin Microbiol	10.1128/jcm.29.4.819-821.1991	1991
Enzymology	Harnessing of urease activity of Helicobacter pylori to induce self-destruction of the bacterium.	Greig MA, Neithercut WD, Hossack M, McColl KE.	J Clin Pathol	10.1136/jcp.44.2.157	1991
	Immune responses to Helicobacter pylori in children with recurrent abdominal pain.	Crabtree JE, Mahony MJ, Taylor JD, Heatley RV, Littlewood JM, Tompkins DS.	J Clin Pathol	10.1136/jcp.44.9.768	1991
	Evaluation of a commercial ELISA for serodiagnosis of Helicobacter pylori infection.	Crabtree JE, Shallcross TM, Heatley RV, Wyatt JI.	J Clin Pathol	10.1136/jcp.44.4.326	1991
Enzymology	Purification and characterization of the urease enzymes of Helicobacter species from humans and animals.	Turbett GR, Hoj PB, Horne R, Mee BJ.	Infect Immun	10.1128/iai.60.12.5259-5266.1992	1992
Enzymology	Potent inhibitory action of the gastric proton pump inhibitor lansoprazole against urease activity of Helicobacter pylori: unique action selective for H. pylori cells.	Nagata K, Satoh H, Iwahi T, Shimoyama T, Tamura T.	Antimicrob Agents Chemother	10.1128/aac.37.4.769	1993
	Cellular fatty acid composition of Campylobacter pylori from primates and ferrets compared with those of other campylobacters.	Goodwin CS, McConnell W, McCulloch RK, McCullough C, Hill R, Bronsdon MA, Kasper G.	J Clin Microbiol	10.1128/jcm.27.5.938-943.1989	1989
	Biochemical studies of Helicobacter mustelae fatty acid composition and flagella.	Suerbaum S, Geis G, Josenhans C, Opferkuch W.	Infect Immun	10.1128/iai.60.4.1695-1698.1992	1992
	Evidence of clonal variants of Helicobacter pylori in three generations of a duodenal ulcer disease family.	Nwokolo CU, Bickley J, Attard AR, Owen RJ, Costas M, Fraser IA.	Gut	10.1136/gut.33.10.1323	1992
Pathogenicity	Ribotyping patterns and emergence of metronidazole resistance in paired clinical samples of Helicobacter pylori.	Rautelin H, Tee W, Seppala K, Kosunen TU.	J Clin Microbiol	10.1128/jcm.32.4.1079-1082.1994	1994
	Compositional analysis of Helicobacter pylori rough-form lipopolysaccharides.	Moran AP, Helander IM, Kosunen TU.	J Bacteriol	10.1128/jb.174.4.1370-1377.1992	1992
	Nutritional requirements for growth of Helicobacter pylori.	Nedenskov P.	Appl Environ Microbiol	10.1128/aem.60.9.3450-3453.1994	1994
Phylogeny	Ribotyping of Helicobacter pylori from clinical specimens.	Tee W, Lambert J, Smallwood R, Schembri M, Ross BC, Dwyer B.	J Clin Microbiol	10.1128/jcm.30.6.1562-1567.1992	1992
Pathogenicity	Antibacterial action of the urease inhibitor acetohydroxamic acid on Helicobacter pylori.	Phillips K, Munster DJ, Allardyce RA, Bagshaw PF.	J Clin Pathol	10.1136/jcp.46.4.372	1993
Pathogenicity	Role of metronidazole resistance in therapy of Helicobacter pylori infections.	Rautelin H, Seppala K, Renkonen OV, Vainio U, Kosunen TU.	Antimicrob Agents Chemother	10.1128/aac.36.1.163	1992
Pathogenicity	Comparative evaluation of the E test, agar dilution, and broth microdilution for testing susceptibilities of Helicobacter pylori strains to 20 antimicrobial agents.	Piccolomini R, Di Bonaventura G, Catamo G, Carbone F, Neri M.	J Clin Microbiol	10.1128/jcm.35.7.1842-1846.1997	1997
Enzymology	Helicobacter pylori associated phospholipase A2 activity: a factor in peptic ulcer production?	Langton SR, Cesareo SD.	J Clin Pathol	10.1136/jcp.45.3.221	1992
Enzymology	An association between sudden infant death syndrome (SIDS) and Helicobacter pylori infection.	Kerr JR, Al-Khattaf A, Barson AJ, Burnie JP.	Arch Dis Child	10.1136/adc.83.5.429	2000
	Helicobacter pylori expresses a complex surface carbohydrate, Lewis X.	Sherburne R, Taylor DE.	Infect Immun	10.1128/iai.63.12.4564-4568.1995	1995
	Helicobacter pylori in Gambian children with chronic diarrhoea and malnutrition.	Sullivan PB, Thomas JE, Wight DG, Neale G, Eastham EJ, Corrah T, Lloyd-Evans N, Greenwood BM.	Arch Dis Child	10.1136/adc.65.2.189	1990
	Systemic and mucosal humoral responses to Helicobacter pylori in gastric cancer.	Crabtree JE, Wyatt JI, Sobala GM, Miller G, Tompkins DS, Primrose JN, Morgan AG.	Gut	10.1136/gut.34.10.1339	1993
Enzymology	Helicobacter pylori: 10th anniversary of its culture in April 1982.	Goodwin CS.	Gut	10.1136/gut.34.3.293	1993
Metabolism	Acute Helicobacter pylori infection: clinical features, local and systemic immune response, gastric mucosal histology, and gastric juice ascorbic acid concentrations.	Sobala GM, Crabtree JE, Dixon MF, Schorah CJ, Taylor JD, Rathbone BJ, Heatley RV, Axon AT.	Gut	10.1136/gut.32.11.1415	1991
	Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.	Bamford KB, Bickley J, Collins JS, Johnston BT, Potts S, Boston V, Owen RJ, Sloan JM.	Gut	10.1136/gut.34.10.1348	1993
Metabolism	Suicidal destruction of Helicobacter pylori: metabolic consequence of intracellular accumulation of ammonia.	Neithercut WD, Greig MA, Hossack M, McColl KE.	J Clin Pathol	10.1136/jcp.44.5.380	1991
	Healing of protein losing hypertrophic gastropathy by eradication of Helicobacter pylori--is Helicobacter pylori a pathogenic factor in Ménétrier's disease?	Bayerdorffer E, Ritter MM, Hatz R, Brooks W, Ruckdeschel G, Stolte M.	Gut	10.1136/gut.35.5.701	1994
Enzymology	Immunological and molecular characterization of Helicobacter felis urease.	Gootz TD, Perez-Perez GI, Clancy J, Martin BA, Tait-Kamradt A, Blaser MJ.	Infect Immun	10.1128/iai.62.3.793-798.1994	1994
Phylogeny	Molecular typing of Helicobacter pylori isolates from asymptomatic, ulcer and gastritis patients by urease gene polymorphism.	Desai M, Linton D, Owen RJ, Stanley J.	Epidemiol Infect	10.1017/s0950268800057514	1994
Enzymology	Direct polymerase chain reaction test for detection of Helicobacter pylori in humans and animals.	Ho SA, Hoyle JA, Lewis FA, Secker AD, Cross D, Mapstone NP, Dixon MF, Wyatt JI, Tompkins DS, Taylor GR.	J Clin Microbiol	10.1128/jcm.29.11.2543-2549.1991	1991
Enzymology	Use of an alkaline phosphatase-labeled synthetic oligonucleotide probe for detection of Campylobacter jejuni and Campylobacter coli.	Olive DM, Johny M, Sethi SK.	J Clin Microbiol	10.1128/jcm.28.7.1565-1569.1990	1990
	Serodiagnosis of Helicobacter pylori infection in childhood.	Thomas JE, Whatmore AM, Barer MR, Eastham EJ, Kehoe MA.	J Clin Microbiol	10.1128/jcm.28.12.2641-2646.1990	1990
Metabolism	Identification of carboxylation enzymes and characterization of a novel four-subunit pyruvate:flavodoxin oxidoreductase from Helicobacter pylori.	Hughes NJ, Chalk PA, Clayton CL, Kelly DJ.	J Bacteriol	10.1128/jb.177.14.3953-3959.1995	1995
Metabolism	Characterization of "Campylobacter pyloridis" by culture, enzymatic profile, and protein content.	Megraud F, Bonnet F, Garnier M, Lamouliatte H.	J Clin Microbiol	10.1128/jcm.22.6.1007-1010.1985	1985
	Measurement of motility of Helicobacter pylori, Campylobacter jejuni, and Escherichia coli by real time computer tracking using the Hobson BacTracker.	Karim QN, Logan RP, Puels J, Karnholz A, Worku ML.	J Clin Pathol	10.1136/jcp.51.8.623	1998
	Systemic and local immune responses against Helicobacter pylori urease in patients with chronic gastritis: distinct IgA and IgG productive sites.	Futagami S, Takahashi H, Norose Y, Kobayashi M.	Gut	10.1136/gut.43.2.168	1998
	Clinical and histological associations of cagA and vacA genotypes in Helicobacter pylori gastritis.	Warburton VJ, Everett S, Mapstone NP, Axon AT, Hawkey P, Dixon MF.	J Clin Pathol	10.1136/jcp.51.1.55	1998
Phylogeny	DNA-DNA hybridization incompatibility of Campylobacter pylori with other Campylobacter and Wolinella species.	Bukholm G, Nedenskov-Sorensen P, Bovre K	APMIS		1989
Phylogeny	Strain variation in Campylobacter pylori detected by numerical analysis of one-dimensional electrophoretic protein patterns.	Owen RJ, Costas M, Morgan DD, On SL, Hill LR, Pearson AD, Morgan DR	Antonie Van Leeuwenhoek	10.1007/BF00393854	1989
Pathogenicity	Susceptibility of Campylobacter pylori to macrolides and fluoroquinolones.	Hardy DJ, Hanson CW, Hensey DM, Beyer JM, Fernandes PB	J Antimicrob Chemother	10.1093/jac/22.5.631	1988
Pathogenicity	GC content of DNA of Campylobacter pylori and other species belonging or related to the genus Campylobacter.	Beji A, Megraud F, Vincent P, Gavini F, Izard D, Leclerc H	Ann Inst Pasteur Microbiol	10.1016/0769-2609(88)90152-4	1988
	The effect of cooling rate, freeze-drying suspending fluid and culture age on the preservation of Campylobacter pylori.	Owen RJ, On SL, Costas M	J Appl Bacteriol	10.1111/j.1365-2672.1989.tb02486.x	1989

References

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Helicobacter pylori (CCUG 15815, LMG 7540, CIP 103995)

Name and taxonomic classification