Helicobacter pylori (DSM 10242, NCTC 11638, RPH 13491)

Name: Helicobacter pylori (DSM 10242, NCTC 11638, RPH 13491)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6101

Type strain

Strain Designation RPH 13491

Culture col. no. DSM 10242 NCTC 11638 RPH 13491 CCUG 17875 LMG 7542 2 more

NCBI tax ID(s) 102619 210

Special Collections DSMZ CCUG CIP

History <- NCTC; NCTC 11638 <- C. S. Goodwin; RPH 13491 CIP <- 2001, CCUG <- C.S. Goodwin, Perth, Western Australia

Links

Helicobacter pylori RPH 13491 is a microaerophile, Gram-negative, motile bacterium that was isolated from human gastric antrum.

Gram-negative motile rod-shaped microaerophile genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 48787

CCUG 17875,LMG 7542,NCTC 11638,LMG 7541,DSM 10242,CIP 107264

@ref 20215

Last LPSN update 2026-02-09 11:19:07

Domain Bacteria

Phylum Pseudomonadota

Class Epsilonproteobacteria

Order Campylobacterales

Family Helicobacteraceae

Genus Helicobacter

Species Helicobacter pylori

Full scientific name Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989

Synonyms (3)

Helicobacter nemestrinae
Campylobacter pylori
Campylobacter pyloridis

BacDive ID	Other strains from **Helicobacter pylori** (69)	Type strain
6102	H. pylori RPH 13487, CCUG 15815, LMG 7540, CIP 103995, ... (type strain)
6099	H. pylori T81213-NTB, T81123-NTB, DSM 7492, ATCC 49396, ...
6100	H. pylori Göteborg 113, DSM 9691, CCUG 21658
24099	H. pylori ASTRA J99, J99, DSM 28160, CCUG 47164, ATCC ...
135116	H. pylori 85P, CIP 104086, JCM 12095
135395	H. pylori N6, CIP 104085, JCM 12094
135934	H. pylori 26695, CIP 106780, JCM 12097
137187	H. pylori CGLO-1, CIP 101260, JCM 12092, CCUG 18943, ...
142935	H. pylori CCUG 15815 B
142936	H. pylori CCUG 15816 B, LMG 8773
142937	H. pylori CCUG 15817
142938	H. pylori CCUG 15818, ATCC 43629, NCTC 11639, LMG 8927, ...
143086	H. pylori CCUG 17135, CCUG 17073
143299	H. pylori CCUG 18295
143328	H. pylori CCUG 18430
143425	H. pylori CCUG 19087
143430	H. pylori CCUG 19104
143431	H. pylori CCUG 19106, LMG 8775
143432	H. pylori CCUG 19107
143433	H. pylori CCUG 19110
143627	H. pylori CCUG 20649
143831	H. pylori CCUG 21365
143840	H. pylori CCUG 21460
143952	H. pylori CCUG 22032
143953	H. pylori CCUG 22035
143954	H. pylori CCUG 22036
143955	H. pylori CCUG 22037
143964	H. pylori CCUG 22110
143980	H. pylori CCUG 22225, LMG 8164
144370	H. pylori CCUG 24780
146346	H. pylori CCUG 30985
146347	H. pylori CCUG 30986
146348	H. pylori CCUG 30987
146349	H. pylori CCUG 30988
146350	H. pylori CCUG 30989
146351	H. pylori CCUG 30990
146352	H. pylori CCUG 30992
146353	H. pylori CCUG 30993
146354	H. pylori CCUG 30994
146462	H. pylori CCUG 31209
148598	H. pylori CCUG 35689
148752	H. pylori CCUG 35899
148764	H. pylori CCUG 35914
149009	H. pylori CCUG 36718
149010	H. pylori CCUG 36719
149969	H. pylori CCUG 38770
149970	H. pylori CCUG 38771
149971	H. pylori CCUG 38772
150213	H. pylori CCUG 39297
150435	H. pylori CCUG 39924
150675	H. pylori CCUG 41936, ATCC 700392, NCTC 12455
152974	H. pylori CCUG 48166
156766	H. pylori CCUG 64957
157640	H. pylori 82894, DSM 105195
157641	H. pylori 85107, DSM 105196
157642	H. pylori 87041, DSM 105197
157643	H. pylori 86298, DSM 105198
157644	H. pylori 85369, DSM 105199
157645	H. pylori 85592, DSM 105200
157646	H. pylori 86153, DSM 105260
157647	H. pylori 83321, DSM 105261
157648	H. pylori G27, DSM 105292
157649	H. pylori J166, DSM 105293
157650	H. pylori PMSS1, DSM 105294
157651	H. pylori 2808, DSM 105296
157652	H. pylori Sydney strain, SS1, DSM 105297
157653	H. pylori Tx30, DSM 105400, ATCC 51932
157654	H. pylori 85593, DSM 105470
157655	H. pylori 85866, DSM 105471

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
122082	negative	rod-shaped

Colony morphology

@ref	Incubation period
3863	1-2 days
122082

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
3863	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
36116	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
122082	CIP Medium 45	Medium recipe at CIP
122082	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
3863	positive	growth	37
36116	positive	growth	37
46706	positive	growth	37
122082	positive	growth	37-41
122082	negative	growth	5
122082	negative	growth	10
122082	negative	growth	25
122082	negative	growth	30
122082	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
3863	microaerophile
46706	microaerophile
122082	microaerophile

Halophily

@ref	Salt	Growth	Tested relation	Concentration
122082	NaCl		growth	3.5 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68373	30089 ChEBI	acetate	-	assimilation	from API CAM
68373	17634 ChEBI	D-glucose	-	assimilation	from API CAM
122082	606565 ChEBI	hippurate	+	hydrolysis
68373	25115 ChEBI	malate	-	assimilation	from API CAM
68373	17632 ChEBI	nitrate	-	reduction	from API CAM
122082	17632 ChEBI	nitrate	-	reduction
122082	16301 ChEBI	nitrite	-	reduction
68373	17272 ChEBI	propionate	-	assimilation	from API CAM
68373	16199 ChEBI	urea	+	hydrolysis	from API CAM

Antibiotic resistance

@ref	ChEBI	Metabolite	Sensitivity conc.
122082		0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)
68373	474053	cefazolin	224 µg	from API CAM
68373	48923	erythromycin	14 µg	from API CAM
68373	100147	nalidixic acid	84 µg	from API CAM

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68373	16136 ChEBI	hydrogen sulfide		from API CAM
122082	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68373	alkaline phosphatase	+	3.1.3.1	from API CAM
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	-	3.2.1.23	from API zym
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
3863	catalase	+	1.11.1.6
122082	catalase	+	1.11.1.6
68373	catalase	+	1.11.1.6	from API CAM
68382	cystine arylamidase	+	3.4.11.3	from API zym
3863	cytochrome-c oxidase	+	1.9.3.1
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
122082	gamma-glutamyltransferase	+	2.3.2.2
68373	gamma-glutamyltransferase	+	2.3.2.2	from API CAM
68373	L-aspartate arylamidase	-	3.4.11.21	from API CAM
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
122082	oxidase	+
68382	trypsin	-	3.4.21.4	from API zym
122082	urease	+	3.5.1.5
68373	urease	+	3.5.1.5	from API CAM
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
122082	-	+	+	+	-	+	-	+	-	-	+	+	-	-	-	-	-	-	-	-

API CAM

@ref	URE	Reduction of nitrateNIT	EsteraseEST	HIP	GGT	TTC	PYRA	L-arginine arylamidaseArgA	L-aspartic acid arylamidaseAspA	PAL	H2S productionH2S	GLU	SUT	NAL	CFZ	ACE	PROP	MLT	CIT	Erythromycin resistance (+) sensitivity (-)ERO	CAT
3863	+	-	-	+	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	+/-	-	not determinedn.d.
3863	+	-	-	-	+	+	-	+	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
46706	+	-	+	-	+	+	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3863	+	-	-	-	+	-	+	-	-	+	-	-	+/-	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2
#Host	#Human
#Host Body-Site	#Gastrointestinal tract

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent	Latitude	Longitude	Sampling date
3863	human gastric antrum	Perth	Australia	AUS	Australia and Oceania	-31.9535	115.857 -31.9535/115.857
46706	Human gastric biopsy	Perth,Freemantle	Australia	AUS	Australia and Oceania			1982-04-12
122082	Human, Gastric		Australia	AUS	Australia and Oceania

Taxonmaps

69479

Global distribution of 16S sequence Z25742 (>99% sequence identity) for Helicobacter pylori subclade from Microbeatlas

Aquatic Samples	829
Soil Samples	670
Animal Samples	16307
Plant Samples	278
Total Samples	18084

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
3863	2	Risk group (German classification) According to TRBA 466
122082	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	NCBI tax ID	Score
124043	ASM4504054v1 assembly for Helicobacter pylori CCUG 17875	complete	GCA_045040545	210	99
124043	ASM4085388v1 assembly for Helicobacter pylori NCTC 11638	contig	GCA_040853885	102619	45.9

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	H.pylori gene for 16S ribosomal RNA (partial)	Z25742	1454		210

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Signature patterns of DNA restriction fragments of Helicobacter pylori before and after treatment.	Owen RJ, Fraser J, Costas M, Morgan D, Morgan DR.	J Clin Pathol	10.1136/jcp.43.8.646	1990
Pathogenicity	DNA fingerprints of Helicobacter pylori before and after treatment with omeprazole.	Fraser AG, Bickley J, Owen RJ, Pounder RE.	J Clin Pathol	10.1136/jcp.45.12.1062	1992
Metabolism	Binding of Helicobacter pylori to sialic acid-containing glycolipids of various origins separated on thin-layer chromatograms.	Miller-Podraza H, Milh MA, Teneberg S, Karlsson KA.	Infect Immun	10.1128/iai.65.6.2480-2482.1997	1997
	Pathological significance and molecular characterization of the vacuolating toxin gene of Helicobacter pylori.	Phadnis SH, Ilver D, Janzon L, Normark S, Westblom TU.	Infect Immun	10.1128/iai.62.5.1557-1565.1994	1994
Phylogeny	Ribosomal RNA gene restriction patterns of Helicobacter pylori: analysis and appraisal of Hae III digests as a molecular typing system.	Owen RJ, Hunton C, Bickley J, Moreno M, Linton D.	Epidemiol Infect		1992
Phylogeny	Differentiation of strains of Helicobacter pylori by numerical analysis of 1-D SDS-PAGE protein patterns: evidence for post-treatment recrudescence.	Costas M, Morgan DD, Owen RJ, Morgan DR.	Epidemiol Infect	10.1017/s095026880004930x	1991
	Clinical outcome after infection with Helicobacter pylori does not appear to be reliably predicted by the presence of any of the genes of the cag pathogenicity island.	Jenks PJ, Megraud F, Labigne A.	Gut	10.1136/gut.43.6.752	1998
	Recrudescence of Helicobacter pylori after apparently successful eradication: novel application of randomly amplified polymorphic DNA fingerprinting.	Xia HX, Windle HJ, Marshall DG, Smyth CJ, Keane CT, O'Morain CA.	Gut	10.1136/gut.37.1.30	1995
	Helicobacter pylori: comparison of DNA fingerprints provides evidence for intrafamilial infection.	Bamford KB, Bickley J, Collins JS, Johnston BT, Potts S, Boston V, Owen RJ, Sloan JM.	Gut	10.1136/gut.34.10.1348	1993
	Population genetic analysis of Helicobacter pylori by multilocus enzyme electrophoresis: extensive allelic diversity and recombinational population structure.	Go MF, Kapur V, Graham DY, Musser JM.	J Bacteriol	10.1128/jb.178.13.3934-3938.1996	1996
	Serodiagnosis of Helicobacter pylori: comparison of enzyme-linked immunosorbent assays.	Talley NJ, Newell DG, Ormand JE, Carpenter HA, Wilson WR, Zinsmeister AR, Perez-Perez GI, Blaser MJ.	J Clin Microbiol	10.1128/jcm.29.8.1635-1639.1991	1991
Metabolism	Association between Helicobacter pylori infection and serum pepsinogen concentrations in gastroduodenal disease.	Matsumoto K, Konishi N, Ohshima M, Hiasa Y, Kimura E, Samori T.	J Clin Pathol	10.1136/jcp.49.12.1005	1996
	Failure of Campylobacter pylori to grow in commercial blood culture systems.	Westblom TU, Madan E, Midkiff BR, Adkins VW, Subik MA.	J Clin Microbiol	10.1128/jcm.26.5.1029-1030.1988	1988
	Optimal survival of Helicobacter pylori under various transport conditions.	Soltesz V, Zeeberg B, Wadstrom T.	J Clin Microbiol	10.1128/jcm.30.6.1453-1456.1992	1992
	Ribosomal RNA gene patterns of Helicobacter pylori from surgical patients with healed and recurrent peptic ulcers.	Owen RJ, Bickley J, Lastovica A, Dunn JP, Borman P, Hunton C.	Epidemiol Infect	10.1017/s0950268800049487	1992
	Seroepidemiology of Helicobacter pylori infection in vegans and meat-eaters.	Webberley MJ, Webberley JM, Newell DG, Lowe P, Melikian V.	Epidemiol Infect	10.1017/s0950268800049967	1992
Cultivation	Growth of Campylobacter pylori in liquid media.	Morgan DR, Freedman R, Depew CE, Kraft WG.	J Clin Microbiol	10.1128/jcm.25.11.2123-2125.1987	1987
Pathogenicity	Evaluation of the E test for quantitative antimicrobial susceptibility testing of Helicobacter pylori.	Glupczynski Y, Labbe M, Hansen W, Crokaert F, Yourassowsky E.	J Clin Microbiol	10.1128/jcm.29.9.2072-2075.1991	1991
Enzymology	Direct polymerase chain reaction test for detection of Helicobacter pylori in humans and animals.	Ho SA, Hoyle JA, Lewis FA, Secker AD, Cross D, Mapstone NP, Dixon MF, Wyatt JI, Tompkins DS, Taylor GR.	J Clin Microbiol	10.1128/jcm.29.11.2543-2549.1991	1991
Pathogenicity	Role of metronidazole resistance in therapy of Helicobacter pylori infections.	Rautelin H, Seppala K, Renkonen OV, Vainio U, Kosunen TU.	Antimicrob Agents Chemother	10.1128/aac.36.1.163	1992
Pathogenicity	Comparative evaluation of the E test, agar dilution, and broth microdilution for testing susceptibilities of Helicobacter pylori strains to 20 antimicrobial agents.	Piccolomini R, Di Bonaventura G, Catamo G, Carbone F, Neri M.	J Clin Microbiol	10.1128/jcm.35.7.1842-1846.1997	1997
	The major sigma factor (RpoD) from Helicobacter pylori and other gram-negative bacteria shows an enhanced rate of divergence.	Solnick JV, Hansen LM, Syvanen M.	J Bacteriol	10.1128/jb.179.19.6196-6200.1997	1997
	Surface localization of Helicobacter pylori urease and a heat shock protein homolog requires bacterial autolysis.	Phadnis SH, Parlow MH, Levy M, Ilver D, Caulkins CM, Connors JB, Dunn BE.	Infect Immun	10.1128/iai.64.3.905-912.1996	1996
Enzymology	Helicobacter pylori: 10th anniversary of its culture in April 1982.	Goodwin CS.	Gut	10.1136/gut.34.3.293	1993
Enzymology	Characterization and presumptive identification of Helicobacter pylori isolates from rhesus monkeys.	Drazek ES, Dubois A, Holmes RK.	J Clin Microbiol	10.1128/jcm.32.7.1799-1804.1994	1994
	Cellular fatty acid composition of Campylobacter pylori from primates and ferrets compared with those of other campylobacters.	Goodwin CS, McConnell W, McCulloch RK, McCullough C, Hill R, Bronsdon MA, Kasper G.	J Clin Microbiol	10.1128/jcm.27.5.938-943.1989	1989
	Comparison of commercial serological tests for detection of Helicobacter pylori antibodies.	Talley NJ, Kost L, Haddad A, Zinsmeister AR.	J Clin Microbiol	10.1128/jcm.30.12.3146-3150.1992	1992
	Mutation of the cytotoxin-associated cagA gene does not affect the vacuolating cytotoxin activity of Helicobacter pylori.	Tummuru MK, Cover TL, Blaser MJ.	Infect Immun	10.1128/iai.62.6.2609-2613.1994	1994
	Naturally occurring chronic gastritis and C pylori infection in the rhesus monkey: a potential model for gastritis in man.	Baskerville A, Newell DG.	Gut	10.1136/gut.29.4.465	1988
	High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori.	Cao P, Cover TL.	J Bacteriol	10.1128/jb.179.9.2852-2856.1997	1997
Enzymology	Species-specific oligodeoxynucleotide probes for the identification of periodontal bacteria.	Dix K, Watanabe SM, McArdle S, Lee DI, Randolph C, Moncla B, Schwartz DE.	J Clin Microbiol	10.1128/jcm.28.2.319-323.1990	1990
Metabolism	Interaction of lipopolysaccharides of Helicobacter pylori with basement membrane protein laminin.	Valkonen KH, Wadstrom T, Moran AP.	Infect Immun	10.1128/iai.62.9.3640-3648.1994	1994
	The effect of cooling rate, freeze-drying suspending fluid and culture age on the preservation of Campylobacter pylori.	Owen RJ, On SL, Costas M	J Appl Bacteriol	10.1111/j.1365-2672.1989.tb02486.x	1989
Enzymology	Campylobacter pylori isolated from the stomach of the monkey, Macaca nemestrina.	Bronsdon MA, Schoenknecht FD	J Clin Microbiol	10.1128/jcm.26.9.1725-1728.1988	1988

References

#3863	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 10242
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36116	; Curators of the CIP;
#46706	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 17875
#68373	Automatically annotated from API CAM .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#122082	Collection of Institut Pasteur ; Curators of the CIP; CIP 107264
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Helicobacter pylori (DSM 10242, NCTC 11638, RPH 13491)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Halophily

Metabolite utilization

Antibiotic resistance

Metabolite production

Enzymes

API zym

API CAM

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_045040545

16S sequences

Genome-based predictions

Literature

Literature

References

BacDive

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