Helicobacter pylori (DSM 7492, ATCC 49396, T81213-NTB)

Name: Helicobacter pylori (DSM 7492, ATCC 49396, T81213-NTB)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 6099

Type strain

Strain Designation T81213-NTB, T81123-NTB

Culture col. no. DSM 7492 ATCC 49396 T81213-NTB NCTC 12491 LMG 14378 6 more

NCBI tax ID(s) 210

Special Collections DSMZ CCUG JCM CIP

History DSMZ <- ATCC; ATCC 49396 <- M. A. Bronsdon; T81213-NTB (Helicobacter nemestrinae) JCM <-- CIP 104754 <-- CCUG 45423 <-- ATCC 49396 <-- M. A. Bronsdon T81213-NTB. CIP <- 1997, CCUG, Helicobacter nemestrinae <- 1993, ATCC <- M.A. Bronsdon: strain T81123-NTB

Links

Helicobacter pylori T81213-NTB is a Gram-negative, motile, rod-shaped bacterium that was isolated from gastric mucosa of pigtailed macaque.

Gram-negative motile rod-shaped 16S sequence Bacteria

Name and taxonomic classification

SI-ID 7930

LMG 14378,ATCC 49396,CCUG 32350,CCUG 45423,CIP 104754,CCUG 44615,DSM 7492,NCTC 12491,JCM 12096

@ref 20215

Last LPSN update 2026-05-29 08:26:19

Domain Bacteria

Phylum Pseudomonadota

Class Epsilonproteobacteria

Order Campylobacterales

Family Helicobacteraceae

Genus Helicobacter

Species Helicobacter pylori

Full scientific name Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989

Synonyms (3)

Campylobacter pylori
Campylobacter pyloridis
Helicobacter nemestrinae

BacDive ID	Other strains from **Helicobacter pylori** (69)	Type strain
6102	H. pylori RPH 13487, CCUG 15815, LMG 7540, CIP 103995, ... (type strain)
6100	H. pylori Göteborg 113, DSM 9691, CCUG 21658
6101	H. pylori RPH 13491, DSM 10242, NCTC 11638, CCUG 17875, ...
24099	H. pylori ASTRA J99, J99, DSM 28160, CCUG 47164, ATCC ...
135116	H. pylori 85P, CIP 104086, JCM 12095
135395	H. pylori N6, CIP 104085, JCM 12094
135934	H. pylori 26695, CIP 106780, JCM 12097
137187	H. pylori CGLO-1, CIP 101260, JCM 12092, CCUG 18943, ...
142935	H. pylori CCUG 15815 B
142936	H. pylori CCUG 15816 B, LMG 8773
142937	H. pylori CCUG 15817
142938	H. pylori CCUG 15818, ATCC 43629, NCTC 11639, LMG 8927, ...
143086	H. pylori CCUG 17135, CCUG 17073
143299	H. pylori CCUG 18295
143328	H. pylori CCUG 18430
143425	H. pylori CCUG 19087
143430	H. pylori CCUG 19104
143431	H. pylori CCUG 19106, LMG 8775
143432	H. pylori CCUG 19107
143433	H. pylori CCUG 19110
143627	H. pylori CCUG 20649
143831	H. pylori CCUG 21365
143840	H. pylori CCUG 21460
143952	H. pylori CCUG 22032
143953	H. pylori CCUG 22035
143954	H. pylori CCUG 22036
143955	H. pylori CCUG 22037
143964	H. pylori CCUG 22110
143980	H. pylori CCUG 22225, LMG 8164
144370	H. pylori CCUG 24780
146346	H. pylori CCUG 30985
146347	H. pylori CCUG 30986
146348	H. pylori CCUG 30987
146349	H. pylori CCUG 30988
146350	H. pylori CCUG 30989
146351	H. pylori CCUG 30990
146352	H. pylori CCUG 30992
146353	H. pylori CCUG 30993
146354	H. pylori CCUG 30994
146462	H. pylori CCUG 31209
148598	H. pylori CCUG 35689
148752	H. pylori CCUG 35899
148764	H. pylori CCUG 35914
149009	H. pylori CCUG 36718
149010	H. pylori CCUG 36719
149969	H. pylori CCUG 38770
149970	H. pylori CCUG 38771
149971	H. pylori CCUG 38772
150213	H. pylori CCUG 39297
150435	H. pylori CCUG 39924
150675	H. pylori CCUG 41936, ATCC 700392, NCTC 12455
152974	H. pylori CCUG 48166
156766	H. pylori CCUG 64957
157640	H. pylori 82894, DSM 105195
157641	H. pylori 85107, DSM 105196
157642	H. pylori 87041, DSM 105197
157643	H. pylori 86298, DSM 105198
157644	H. pylori 85369, DSM 105199
157645	H. pylori 85592, DSM 105200
157646	H. pylori 86153, DSM 105260
157647	H. pylori 83321, DSM 105261
157648	H. pylori G27, DSM 105292
157649	H. pylori J166, DSM 105293
157650	H. pylori PMSS1, DSM 105294
157651	H. pylori 2808, DSM 105296
157652	H. pylori Sydney strain, SS1, DSM 105297
157653	H. pylori Tx30, DSM 105400, ATCC 51932
157654	H. pylori 85593, DSM 105470
157655	H. pylori 85866, DSM 105471

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility
122083	negative	rod-shaped

Colony morphology

122083

Hemolysis ability0

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
3190	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
39088	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
122083	Brucella broth
122083	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
3190	positive	growth	37
39088	positive	growth	37
67770	positive	growth	37
122083	positive	growth	30-41
122083	negative	growth	5
122083	negative	growth	10
122083	negative	growth	25
122083	negative	growth	45

Physiology and metabolism

Halophily

@ref	Salt	Growth	Tested relation	Concentration
122083	NaCl		growth	3.5 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68373	30089 ChEBI	acetate	-	assimilation	from API CAM
68373	16947 ChEBI	citrate	-	assimilation	from API CAM
68373	17634 ChEBI	D-glucose	-	assimilation	from API CAM
68373	606565 ChEBI	hippurate	-	hydrolysis	from API CAM
122083	606565 ChEBI	hippurate	-	hydrolysis
68373	25115 ChEBI	malate	-	assimilation	from API CAM
68373	17632 ChEBI	nitrate	-	reduction	from API CAM
122083	17632 ChEBI	nitrate	-	reduction
122083	16301 ChEBI	nitrite	-	reduction
68373	17272 ChEBI	propionate	-	assimilation	from API CAM
68373	16199 ChEBI	urea	+	hydrolysis	from API CAM

Antibiotic resistance

@ref	ChEBI	Group ID	Metabolite	Sensitivity conc.
122083			0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)
68373	474053	0	cefazolin	224 µg	from API CAM
68373	48923	0	erythromycin	14 µg	from API CAM
68373	100147	0	nalidixic acid	84 µg	from API CAM

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68373	16136 ChEBI	hydrogen sulfide		from API CAM
122083	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68373	alkaline phosphatase	+	3.1.3.1	from API CAM
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	+	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	-	3.2.1.23	from API zym
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
122083	catalase	+	1.11.1.6
68373	catalase	+	1.11.1.6	from API CAM
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
122083	gamma-glutamyltransferase	+	2.3.2.2
68373	gamma-glutamyltransferase	+	2.3.2.2	from API CAM
122083	gelatinase	-
68373	L-aspartate arylamidase	-	3.4.11.21	from API CAM
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
122083	oxidase	+
68373	pyrrolidonyl arylamidase	-	3.4.19.3	from API CAM
68382	trypsin	-	3.4.21.4	from API zym
122083	urease	+	3.5.1.5
68373	urease	+	3.5.1.5	from API CAM
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
122083	-	+	+	+	-	+	-	-	-	-	+	+	-	-	-	+	-	-	-	-

API CAM

@ref	URE	Reduction of nitrateNIT	EsteraseEST	HIP	GGT	TTC	PYRA	L-arginine arylamidaseArgA	L-aspartic acid arylamidaseAspA	PAL	H2S productionH2S	GLU	SUT	NAL	CFZ	ACE	PROP	MLT	CIT	Erythromycin resistance (+) sensitivity (-)ERO	CAT
3190	+	-	-	-	+	-	-	-	-	+	-	-	+	-	-	-	-	-	-	-	+
3190	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3190	+	-	+	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3190	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3190	+	-	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+
3190	+	-	+	-	+	+	-	+	-	+	-	-	-	-	-	-	-	-	-	-	+
3190	+	-	+/-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Mammals	#Primates
#Host Body-Site	#Gastrointestinal tract	#Stomach

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent	Latitude	Longitude	Host species
3190	gastric mucosa of pigtailed macaque	Seattle	USA	USA	North America	47.6062	-122.332 47.6062/-122.332
67770	Gastric mucosa of a 6-year-old healthy pigtailed macaque (Macaca nemestrina)							Macaca nemestrina
122083	Animal, Pig - tailed macaque, gastric mucosa		United States of America	USA	North America

Taxonmaps

69479

Global distribution of 16S sequence LC507449 (>99% sequence identity) for Helicobacter pylori subclade from Microbeatlas

Aquatic Samples	829
Soil Samples	670
Animal Samples	16307
Plant Samples	278
Total Samples	18084

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
3190	2	Risk group (German classification) According to TRBA 466
122083	2	Risk group (French classification) According to TRBA 466

Sequence information

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Helicobacter nemestrinae 16S ribosomal RNA gene, partial sequence	AF348617	1477	210
20218	Helicobacter nemestrinae strain ATCC49396 16S ribosomal RNA gene, partial sequence	AF363064	1437	210
20218	H.nemestrinae (ATCC 49396T) gene for 16S rRNA	X67854	1463	210
67770	Helicobacter pylori JCM 12096 gene for 16S ribosomal RNA, partial sequence	LC507449	1426	210

GC content

@ref	GC-content (mol%)	Method
3190	24.0
67770	24	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Phylogeny	Diagnosis of Genus Helicobacter through a hemi-nested PCR assay of 16S rRNA.	Qin H, Tang G, Yi P, Pan X, Huang H, Chang R, Shi Z, Ashraf MA.	Saudi Pharm J	10.1016/j.jsps.2016.04.015	2016
Genetics	Whole-Genome Sequencing and Bioinformatics as Pertinent Tools to Support Helicobacteracae Taxonomy, Based on Three Strains Suspected to Belong to Novel Helicobacter Species.	Berthenet E, Benejat L, Menard A, Varon C, Lacomme S, Gontier E, Raymond J, Boussaba O, Toulza O, Ducournau A, Buissonniere A, Giese A, Megraud F, Bessede E, Jehanne Q, Lehours P.	Front Microbiol	10.3389/fmicb.2019.02820	2019
Phylogeny	Identification of thermotolerant campylobacter species by fluorescence in situ hybridization.	Poppert S, Haas M, Yildiz T, Alter T, Bartel E, Fricke U, Essig A.	J Clin Microbiol	10.1128/jcm.01512-07	2008
Enzymology	Specific detection and prevalence of Helicobacter heilmannii-like organisms in the human gastric mucosa by fluorescent in situ hybridization and partial 16S ribosomal DNA sequencing.	Trebesius K, Adler K, Vieth M, Stolte M, Haas R.	J Clin Microbiol	10.1128/jcm.39.4.1510-1516.2001	2001
Enzymology	Purification and characterization of the urease enzymes of Helicobacter species from humans and animals.	Turbett GR, Hoj PB, Horne R, Mee BJ.	Infect Immun	10.1128/iai.60.12.5259-5266.1992	1992
Phylogeny	Emergence of diverse Helicobacter species in the pathogenesis of gastric and enterohepatic diseases.	Solnick JV, Schauer DB.	Clin Microbiol Rev	10.1128/cmr.14.1.59-97.2001	2001
Pathogenicity	Rapid detection, by PCR and reverse hybridization, of mutations in the Helicobacter pylori 23S rRNA gene, associated with macrolide resistance.	van Doorn LJ, Debets-Ossenkopp YJ, Marais A, Sanna R, Megraud F, Kusters JG, Quint WG.	Antimicrob Agents Chemother	10.1128/aac.43.7.1779	1999
Pathogenicity	Evaluation of antibiotic treatment against "Candidatus Helicobacter suis" in a mouse model.	Hellemans A, Decostere A, Haesebrouck F, Ducatelle R.	Antimicrob Agents Chemother	10.1128/aac.49.11.4530-4535.2005	2005
Pathogenicity	Simultaneous identification of campylobacters and prediction of quinolone resistance by comparative sequence analysis.	Husmann M, Feddersen A, Steitz A, Freytag C, Bhakdi S.	J Clin Microbiol	10.1128/jcm.35.9.2398-2400.1997	1997
Enzymology	Differences in surface-exposed antigen expression between Helicobacter pylori strains isolated from duodenal ulcer patients and from asymptomatic subjects.	Thoreson AC, Hamlet A, Celik J, Bystrom M, Nystrom S, Olbe L, Svennerholm AM.	J Clin Microbiol	10.1128/jcm.38.9.3436-3441.2000	2000
Enzymology	Development of a loop-mediated isothermal amplification assay for rapid Helicobacter pylori detection.	Horiuchi S, Nakano R, Nakano A, Hishiya N, Uno K, Suzuki Y, Tanouchi A, Kakuta N, Masui T, Jojima N, Yano H	J Microbiol Methods	10.1016/j.mimet.2019.105653	2019
Phylogeny	Helicobacter nemestrinae ATCC 49396T is a strain of Helicobacter pylori (Marshall et al. 1985) Goodwin et al. 1989, and Helicobacter nemestrinae Bronsdon et al. 1991 is therefore a junior heterotypic synonym of Helicobacter pylori.	Suerbaum S, Kraft C, Dewhirst FE, Fox JG	Int J Syst Evol Microbiol	10.1099/00207713-52-2-437	2002
Phylogeny	Helicobacter mesocricetorum sp. nov., A novel Helicobacter isolated from the feces of Syrian hamsters.	Simmons JH, Riley LK, Besch-Williford CL, Franklin CL.	J Clin Microbiol	10.1128/jcm.38.5.1811-1817.2000	2000
Phylogeny	Helicobacter winghamensis sp. nov., a novel Helicobacter sp. isolated from patients with gastroenteritis.	Melito PL, Munro C, Chipman PR, Woodward DL, Booth TF, Rodgers FG.	J Clin Microbiol	10.1128/jcm.39.7.2412-2417.2001	2001
Phylogeny	Helicobacter nemestrinae sp. nov., a spiral bacterium found in the stomach of a pigtailed macaque (Macaca nemestrina)	Bronsdon MA, Goodwin CS, Sly LI, Chilvers T, Schoenknecht FD	Int J Syst Bacteriol	10.1099/00207713-41-1-148	1991

References

#3190	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 7492
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#39088	; Curators of the CIP;
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68373	Automatically annotated from API CAM .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#122083	Collection of Institut Pasteur ; Curators of the CIP; CIP 104754
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Helicobacter pylori (DSM 7492, ATCC 49396, T81213-NTB)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Halophily

Metabolite utilization

Antibiotic resistance

Metabolite production

Enzymes

API zym

API CAM

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

16S sequences

GC content

Genome-based predictions

Literature

Literature

References

BacDive

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