Haloferax mediterranei (DSM 1411, ATCC 33500, CCM 3361)

Name: Haloferax mediterranei (DSM 1411, ATCC 33500, CCM 3361)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 5932

Type strain

Strain Designation R-4

Culture col. no. DSM 1411 ATCC 33500 CCM 3361 R-4 JCM 8866 8 more

NCBI tax ID(s) 523841 2252

Special Collections DSMZ JCM

History DSMZ <- F. Rodriguez-Valera, R-4 JCM <-- IFO 14739 <-- ATCC 33500 <-- F. Rodoriguez-Valera R-4.

Links

Haloferax mediterranei R-4 is an archaeon that was isolated from solar salt pond.

genome sequence 16S sequence Archaea

Name and taxonomic classification

SI-ID 40524

ATCC 33500,CCM 3361,IFO 14739,NCMB 2177,DSM 1411,JCM 8866,NCIMB 2177,VKM B-1748,VKM B-1538,NBRC 14739,BCRC 15765,CCRC 15765,IAM 13647,CGMCC 1.2087,CGMCC 1.2143,CGMCC 1.2630

@ref 20215

Last LPSN update 2026-05-29 08:26:17

Domain Archaea

Phylum Methanobacteriota

Class Halobacteria

Order Halobacteriales

Family Haloferacaceae

Genus Haloferax

Species Haloferax mediterranei

Full scientific name Haloferax mediterranei (Rodriguez-Valera et al. 1983) Torreblanca et al. 1987

Synonyms (1)

Halobacterium mediterranei

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
496	HALOBACTERIA MEDIUM (DSMZ Medium 372)		Medium recipe at MediaDive	Name: HALOBACTERIA MEDIUM (DSMZ Medium 372) Composition: NaCl 200.0 g/l MgSO4 x 7 H2O 20.0 g/l Agar 20.0 g/l Yeast extract 5.0 g/l Casamino acids 5.0 g/l Na3-citrate 3.0 g/l KCl 2.0 g/l Na glutamate 1.0 g/l FeCl2 x 4 H2O 0.036 g/l MnCl2 x 4 H2O 0.00036 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
496	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	facultative anaerobe	92.086

Spore formation

@ref	Spore formation	Confidence
125439		97.797

Observation

67770

Observationquinones: MK-8

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Aquatic	#Pond (small)
#Condition	#Saline	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
496	solar salt pond	near Alicante	Spain	ESP	Europe
67770	Salt pond near Alicante		Spain	ESP	Europe

Taxonmaps

69479

Global distribution of 16S sequence D11107 (>99% sequence identity) for Haloferax from Microbeatlas

Aquatic Samples	3
Soil Samples	2
Animal Samples	0
Plant Samples	0
Total Samples	5

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
496	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM30676v2 assembly for Haloferax mediterranei ATCC 33500 CGMCC 1.2087	complete	GCA_000306765	523841.19	2521172713	523841	98.62
66792	Haloferax mediterranei R-4	complete			2508501019	523841	98.12
66792	ASM540632v1 assembly for Haloferax mediterranei ATCC 33500	complete	GCA_005406325	523841.46		523841	97.79
66792	ASM68563v1 assembly for Haloferax mediterranei ATCC 33500	chromosome	GCA_000685635	523841.20	2576861458	523841	83.33
124043	ASM3384302v1 assembly for Haloferax mediterranei ATCC 33500	contig	GCA_033843025			523841	78.58
67770	ASM33729v1 assembly for Haloferax mediterranei ATCC 33500	contig	GCA_000337295	523841.21	2529293245	523841	76.31

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Haloferax mediterranei ATCC 33500 16S ribosomal RNA gene, partial sequence; 16S-23S ribosomal RNA spacer region and tRNA-Ala genes, complete sequence; 23S ribosomal RNA genes, partial sequence; 23S-5S ribosomal RNA spacer region gene, complete sequence; and 5S ribosomal RNA gene, partial sequence	AH009830	422	523841
496	Haloferax mediterranei gene for 16S rRNA, strain: ATCC 33500	D11107	1472	523841
124043	Haloferax mediterranei gene for 16S rRNA, complete sequence, strain: JCM 8866.	AB663379	1473	2252

GC content

@ref	GC-content (mol%)	Method
496	60.0
67770	62.2	Buoyant density centrifugation (BD)
67770	60	fluorimetric
67770	59.1	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM30676v2 assembly for Haloferax mediterranei ATCC 33500 CGMCC 1.2087
BV-BRC: 523841.19

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	92.09	no
125439	gram_stain	BacteriaNetⓘ	negative	65.79	no
125439	motility	BacteriaNetⓘ	yes	40.51	no
125439	spore_formation	BacteriaNetⓘ	no	97.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Haloferax mediterranei ATCC 33500 ATCC 33500
NCBI: GCA_005406325.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	73.89	no
125438	anaerobic	anaerobicⓘ	no	83.80	no
125438	aerobic	aerobicⓘ	yes	83.58	no
125438	spore-forming	spore-formingⓘ	no	80.63	no
125438	thermophilic	thermophileⓘ	no	81.09	yes
125438	flagellated	motile2+ⓘ	no	82.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Characterizing the growth of PHA-producing microorganisms on short-chain carboxylic acids.	Leonhardt S, Tamang P, Tovar GEM, Zibek S.	Microb Cell Fact	10.1186/s12934-025-02840-8	2025
	Genetic algorithm-optimized artificial neural network for multi-objective optimization of biomass and exopolysaccharide production by Haloferax mediterranei.	Al Rawahi AM, Zafar M, Khan TA, Al Araimi S, Mahanty B, Behera SK.	Bioprocess Biosyst Eng	10.1007/s00449-025-03143-3	2025
	Purification and Characterization of Polyhydroxyalkanoate Synthase from Extremely Halophilic Archaeon Haloferax mediterranei: Key Enzyme of Biodegradable Plastic Synthesis.	Alsafadi D, Ghalawinji Y, Khalili FI.	Bioengineering (Basel)	10.3390/bioengineering12091003	2025
	Bioconversion of bread waste into high-quality proteins and biopolymers by fermentation of archaea Haloferax mediterranei.	Unis R, Gnaim R, Kashyap M, Shamis O, Gnayem N, Gozin M, Liberzon A, Gnaim J, Golberg A.	Front Microbiol	10.3389/fmicb.2024.1491333	2024
	Continuous bioreactor production of polyhydroxyalkanoates in Haloferax mediterranei.	Parroquin-Gonzalez M, Winterburn J.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1220271	2023
Biotechnology	Toward Sustainable Polyhydroxyalkanoates: A Next-Gen Biotechnology Approach.	Kalia VC, Singh RV, Gong C, Lee JK.	Polymers (Basel)	10.3390/polym17070853	2025
	Bioplastic Production from Agri-Food Waste through the Use of Haloferax mediterranei: A Comprehensive Initial Overview	Longo A, Fanelli F, Villano M, Montemurro M, Rizzello C.	Microorganisms		2024
Metabolism	Haloarchaea as Cell Factories to Produce Bioplastics.	Simo-Cabrera L, Garcia-Chumillas S, Hagagy N, Saddiq A, Tag H, Selim S, AbdElgawad H, Arribas Aguero A, Monzo Sanchez F, Canovas V, Pire C, Martinez-Espinosa RM.	Mar Drugs	10.3390/md19030159	2021
	Valorization of Algal Biomass to Produce Microbial Polyhydroxyalkanoates: Recent Updates, Challenges, and Perspectives.	Narayanasamy A, Patel SKS, Singh N, Rohit MV, Lee JK.	Polymers (Basel)	10.3390/polym16152227	2024
	Electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds - a step towards ligament repair applications.	Khamplod T, Winterburn JB, Cartmell SH.	Sci Technol Adv Mater	10.1080/14686996.2022.2149034	2022
Biotechnology	A Review of Polyhydroxyalkanoates: Characterization, Production, and Application from Waste.	Getino L, Martin JL, Chamizo-Ampudia A.	Microorganisms	10.3390/microorganisms12102028	2024
	Soft Sensor-Based Monitoring and Efficient Control Strategies of Biomass Concentration for Continuous Cultures of Haloferax mediterranei and Their Application to an Industrial Production Chain.	Mainka T, Mahler N, Herwig C, Pflugl S.	Microorganisms	10.3390/microorganisms7120648	2019
Biotechnology	Reducing Organic Load From Industrial Residual Process Brine With a Novel Halophilic Mixed Culture: Scale-Up and Long-Term Piloting of an Integrated Bioprocess.	Mainka T, Herwig C, Pflugl S.	Front Bioeng Biotechnol	10.3389/fbioe.2022.896576	2022
	What Is New in the Field of Industrial Wastes Conversion into Polyhydroxyalkanoates by Bacteria?	Marciniak P, Mozejko-Ciesielska J.	Polymers (Basel)	10.3390/polym13111731	2021
	Utilization of Sugarcane Bagasse by Halogeometricum borinquense Strain E3 for Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate).	Salgaonkar BB, Braganca JM.	Bioengineering (Basel)	10.3390/bioengineering4020050	2017
	Utilization of vinasse for production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) by Haloferax mediterranei.	Bhattacharyya A, Pramanik A, Maji SK, Haldar S, Mukhopadhyay UK, Mukherjee J.	AMB Express	10.1186/2191-0855-2-34	2012
	Targeting Aspergillus allergen oryzin with a chemical probe at atomic precision.	Pattelli ON, Diec DDL, Guo W, Russi S, Fernandez D.	Sci Rep	10.1038/s41598-023-45028-z	2023
Enzymology	Recent Trends in the Production and Recovery of Bioplastics Using Polyhydroxyalkanoates Copolymers.	Garcia A, Aguirre C, Perez A, Bahamonde SS, Urtuvia V, Diaz-Barrera A, Pena C.	Microorganisms	10.3390/microorganisms12112135	2024
Metabolism	Archaeal production of polyhydroxyalkanoate (PHA) co- and terpolyesters from biodiesel industry-derived by-products.	Hermann-Krauss C, Koller M, Muhr A, Fasl H, Stelzer F, Braunegg G.	Archaea	10.1155/2013/129268	2013
Metabolism	Food waste conversion to microbial polyhydroxyalkanoates.	Nielsen C, Rahman A, Rehman AU, Walsh MK, Miller CD.	Microb Biotechnol	10.1111/1751-7915.12776	2017
	Generation of PHB from Spent Sulfite Liquor Using Halophilic Microorganisms.	Weissgram M, Gstottner J, Lorantfy B, Tenhaken R, Herwig C, Weber HK.	Microorganisms	10.3390/microorganisms3020268	2015
	The nucleotide sequence of the 5S rRNA from the archaebacterium Haloferax mediterranei.	McDougall J.	Nucleic Acids Res	10.1093/nar/17.8.3296	1989
Pathogenicity	Cell cycle arrest in archaea by the hypusination inhibitor N(1)-guanyl-1,7-diaminoheptane.	Jansson BP, Malandrin L, Johansson HE.	J Bacteriol	10.1128/jb.182.4.1158-1161.2000	2000
	Potential and Prospects of Continuous Polyhydroxyalkanoate (PHA) Production.	Koller M, Braunegg G.	Bioengineering (Basel)	10.3390/bioengineering2020094	2015
	Recent Advances and Challenges towards Sustainable Polyhydroxyalkanoate (PHA) Production.	Kourmentza C, Placido J, Venetsaneas N, Burniol-Figols A, Varrone C, Gavala HN, Reis MAM.	Bioengineering (Basel)	10.3390/bioengineering4020055	2017
	Compilation of 5S rRNA and 5S rRNA gene sequences.	Specht T, Wolters J, Erdmann VA.	Nucleic Acids Res	10.1093/nar/18.suppl.2215	1990
	Identification and Mitigation of Inhibitory Substances Contained in High-Salinity Crude Glycerol Generated from Biodiesel Production for Polyhydroxyalkanoate Synthesis by Haloferax mediterranei.	Zhang X, Helm RF, McCoy EL, Zhao F, Wang M, Li Y, Lansing S, Huang H, Wang Z.	ACS Sustain Chem Eng	10.1021/acssuschemeng.5c05475	2025
	Halocin H4 is activated through cleavage by halolysin HlyR4.	Chen S, Dai Y, Ke J, Luo Y, Wang C, Hao Y, Zhang A, Han J, Xiang H.	Appl Environ Microbiol	10.1128/aem.02284-23	2024
	Production of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) by Haloferax mediterranei Using Candy Industry Waste as Raw Materials.	Simo-Cabrera L, Garcia-Chumillas S, Benitez-Benitez SJ, Canovas V, Monzo F, Pire C, Martinez-Espinosa RM.	Bioengineering (Basel)	10.3390/bioengineering11090870	2024
	Study on the production of high 3HV content PHBV via an open fermentation with waste silkworm excrement as the carbon source by the haloarchaeon Haloferax mediterranei.	Cai S, Wu Y, Liu R, Jia H, Qiu Y, Jiang M, Ma Y, Yang X, Zhang S, Zhao Y, Cai L.	Front Microbiol	10.3389/fmicb.2022.981605	2022
	Deepening the knowledge of universal stress proteins in Haloferax mediterranei.	Matarredona L, Zafrilla B, Rubio-Portillo E, Bonete MJ, Esclapez J.	Appl Microbiol Biotechnol	10.1007/s00253-023-12899-1	2024
	Towards the Understanding of the Function of Lanthipeptide and TOMM-Related Genes in Haloferax mediterranei.	Costa T, Cassin E, Moreirinha C, Mendo S, Caetano TS.	Biology (Basel)	10.3390/biology12020236	2023
	Analysis of the external signals driving the transcriptional regulation of the main genes involved in denitrification in Haloferax mediterranei.	Miralles-Robledillo JM, Martinez-Espinosa RM, Pire C.	Front Microbiol	10.3389/fmicb.2023.1109550	2023
	A Haloarchaeal Transcriptional Regulator That Represses the Expression of CRISPR-Associated Genes.	Turgeman-Grott I, Shalev Y, Shemesh N, Levy R, Eini I, Pasmanik-Chor M, Gophna U.	Microorganisms	10.3390/microorganisms12091772	2024
Genetics	Production, characterization, and genomic insights of a human lectin-binding exopolysaccharide from Haloarcula japonica strain SST1.	Ghevondyan D, Hakobyan A, Margaryan A, Finore I, Cattaneo A, Chiodo F, Birkeland NK, Poli A, Panosyan H.	Sci Rep	10.1038/s41598-025-18462-4	2025
	Halolysin R4 of Haloferax mediterranei confers its host antagonistic and defensive activities.	Chen S, Sun S, Wang R, Feng H, Xiang H.	Appl Environ Microbiol	10.1128/aem.02889-20	2021
	Coupling Magnetic Field and Salinity Upshock To Improve Polyhydroxyalkanoate Productivity by Haloferax mediterranei Feeding on Molasses Wastewater.	Chen S, Cui YW, Huang MQ.	Appl Environ Microbiol	10.1128/aem.00305-22	2022
	Methylomes of Two Extremely Halophilic Archaea Species, Haloarcula marismortui and Haloferax mediterranei.	DasSarma S, Fomenkov A, DasSarma SL, Vincze T, DasSarma P, Roberts RJ.	Microbiol Resour Announc	10.1128/mra.00577-19	2019
Metabolism	Production of Polyhydroxyalkanoates (PHA) by Haloferax mediterranei from Food Waste Derived Nutrients for Biodegradable Plastic Applications.	Wang K, Zhang R.	J Microbiol Biotechnol	10.4014/jmb.2008.08057	2021
	Towards the Elucidation of Assimilative nasABC Operon Transcriptional Regulation in Haloferax mediterranei.	Pastor-Soler S, Camacho M, Bautista V, Bonete MJ, Esclapez J.	Genes (Basel)	10.3390/genes12050619	2021
Metabolism	Haloferax mediterranei Cells as C50 Carotenoid Factories.	Giani M, Montero-Lobato Z, Garbayo I, Vilchez C, Vega JM, Martinez-Espinosa RM.	Mar Drugs	10.3390/md19020100	2021
	Expression, purification, and enzymatic characterization of an extracellular protease from Halococcus salifodinae.	Hong T, Pan R, Ke J, Luo Y, Hao Y, Chen L, Tu D, Dai Y, Chen T, Chen S.	Braz J Microbiol	10.1007/s42770-023-01114-y	2023
Phylogeny	Lipidomic chemotaxonomy aligned with phylogeny of Halobacteria.	Yao W, Zhang W, He W, Xiao W, Chen Y, Zhu Y, Zheng F, Zhang C.	Front Microbiol	10.3389/fmicb.2023.1297600	2023
	Process Development of Polyhydroxyalkanoates Production by Halophiles Valorising Food Waste.	Wang K, Chen C, Zhang R.	Bioengineering (Basel)	10.3390/bioengineering9110630	2022
	Neighboring inteins interfere with one another's homing capacity.	Turgeman-Grott I, Arsenault D, Yahav D, Feng Y, Miezner G, Naki D, Peri O, Papke RT, Gogarten JP, Gophna U.	PNAS Nexus	10.1093/pnasnexus/pgad354	2023
Enzymology	Heterologous and Homologous Expression of Proteins from Haloarchaea: Denitrification as Case of Study.	Martinez-Espinosa RM.	Int J Mol Sci	10.3390/ijms21010082	2019
	Genome Sequence of the Poly-3-Hydroxybutyrate Producer Clostridium acetireducens DSM 10703.	Fluchter S, Poehlein A, Schiel-Bengelsdorf B, Daniel R, Durre P.	Genome Announc	10.1128/genomea.01399-16	2016
	A Halocin Promotes DNA Uptake in Haloferax mediterranei.	Chen S, Sun S, Korfanty GA, Liu J, Xiang H.	Front Microbiol	10.3389/fmicb.2019.01960	2019
Metabolism	Unusual Phosphoenolpyruvate (PEP) Synthetase-Like Protein Crucial to Enhancement of Polyhydroxyalkanoate Accumulation in Haloferax mediterranei Revealed by Dissection of PEP-Pyruvate Interconversion Mechanism.	Chen J, Mitra R, Zhang S, Zuo Z, Lin L, Zhao D, Xiang H, Han J.	Appl Environ Microbiol	10.1128/aem.00984-19	2019
Genetics	Comparative Genomic Insights into the Evolution of Halobacteria-Associated "Candidatus Nanohaloarchaeota".	Zhao D, Zhang S, Kumar S, Zhou H, Xue Q, Sun W, Zhou J, Xiang H.	mSystems	10.1128/msystems.00669-22	2022
Metabolism	Complete genome sequence of the metabolically versatile halophilic archaeon Haloferax mediterranei, a poly(3-hydroxybutyrate-co-3-hydroxyvalerate) producer.	Han J, Zhang F, Hou J, Liu X, Li M, Liu H, Cai L, Zhang B, Chen Y, Zhou J, Hu S, Xiang H.	J Bacteriol	10.1128/jb.00880-12	2012
Metabolism	Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins.	Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H, Li M.	Nucleic Acids Res	10.1093/nar/gkab821	2021
	Small RNAs of Haloferax mediterranei: Identification and Potential Involvement in Nitrogen Metabolism.	Paya G, Bautista V, Camacho M, Castejon-Fernandez N, Alcaraz LA, Bonete MJ, Esclapez J.	Genes (Basel)	10.3390/genes9020083	2018
Metabolism	A patatin-like protein associated with the polyhydroxyalkanoate (PHA) granules of Haloferax mediterranei acts as an efficient depolymerase in the degradation of native PHA.	Liu G, Hou J, Cai S, Zhao D, Cai L, Han J, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.04269-14	2015
	Activation of a dormant replication origin is essential for Haloferax mediterranei lacking the primary origins.	Yang H, Wu Z, Liu J, Liu X, Wang L, Cai S, Xiang H.	Nat Commun	10.1038/ncomms9321	2015
Metabolism	Propionyl coenzyme A (propionyl-CoA) carboxylase in Haloferax mediterranei: Indispensability for propionyl-CoA assimilation and impacts on global metabolism.	Hou J, Xiang H, Han J.	Appl Environ Microbiol	10.1128/aem.03167-14	2015
	An Acidic Exopolysaccharide from Haloarcula hispanica ATCC33960 and Two Genes Responsible for Its Synthesis.	Lu Y, Lu H, Wang S, Han J, Xiang H, Jin C.	Archaea	10.1155/2017/5842958	2017
Genetics	Peeling the Layers Away: The Genomic Characterization of Bacillus pumilus 64-1, an Isolate With Antimicrobial Activity From the Marine Sponge Plakina cyanorosea (Porifera, Homoscleromorpha).	Freitas-Silva J, de Oliveira BFR, Vigoder FM, Muricy G, Dobson ADW, Laport MS.	Front Microbiol	10.3389/fmicb.2020.592735	2020
	Characterization of multicomponent antioxidants from Haloferax alexandrinus GUSF-1 (KF796625).	Alvares JJ, Furtado IJ.	3 Biotech	10.1007/s13205-020-02584-9	2021
Stress	HtrAs are essential for the survival of the haloarchaeon Natrinema gari J7-2 in response to heat, high salinity, and toxic substances.	Luo H, Qu X, Deng X, He L, Wu Y, Liu Y, He D, Yin J, Wang B, Gan F, Tang B, Tang X-F.	Appl Environ Microbiol	10.1128/aem.02048-23	2024
Metabolism	Identification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei.	Cai S, Cai L, Liu H, Liu X, Han J, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.07114-11	2012
	Interplay of intracellular and trans-cellular DNA methylation in natural archaeal consortia.	Reva ON, La Cono V, Crisafi F, Smedile F, Mudaliyar M, Ghosal D, Giuliano L, Krupovic M, Yakimov MM.	Environ Microbiol Rep	10.1111/1758-2229.13258	2024
Metabolism	A novel DNA-binding protein, PhaR, plays a central role in the regulation of polyhydroxyalkanoate accumulation and granule formation in the haloarchaeon Haloferax mediterranei.	Cai S, Cai L, Zhao D, Liu G, Han J, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.02878-14	2015
Metabolism	Multiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei.	Han J, Hou J, Zhang F, Ai G, Li M, Cai S, Liu H, Wang L, Wang Z, Zhang S, Cai L, Zhao D, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.03915-12	2013
Metabolism	Nitrogen regulation of protein-protein interactions and transcript levels of GlnK PII regulator and AmtB ammonium transporter homologs in Archaea.	Pedro-Roig L, Lange C, Bonete MJ, Soppa J, Maupin-Furlow J.	Microbiologyopen	10.1002/mbo3.120	2013
Metabolism	Malate Synthase and beta-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica.	Borjian F, Han J, Hou J, Xiang H, Zarzycki J, Berg IA.	J Bacteriol	10.1128/jb.00657-16	2017
Biotechnology	Synthesis, production, and biotechnological applications of exopolysaccharides and polyhydroxyalkanoates by archaea.	Poli A, Di Donato P, Abbamondi GR, Nicolaus B.	Archaea	10.1155/2011/693253	2011
Phylogeny	Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms.	Boya BR, Kumar P, Lee JH, Lee J.	Microorganisms	10.3390/microorganisms9102156	2021
	Halo(natrono)archaea isolated from hypersaline lakes utilize cellulose and chitin as growth substrates.	Sorokin DY, Toshchakov SV, Kolganova TV, Kublanov IV.	Front Microbiol	10.3389/fmicb.2015.00942	2015
Metabolism	The Halophile protein database.	Sharma N, Farooqi MS, Chaturvedi KK, Lal SB, Grover M, Rai A, Pandey P.	Database (Oxford)	10.1093/database/bau114	2014
	PHA Production and PHA Synthases of the Halophilic Bacterium Halomonas sp. SF2003.	Thomas T, Sudesh K, Bazire A, Elain A, Tan HT, Lim H, Bruzaud S.	Bioengineering (Basel)	10.3390/bioengineering7010029	2020
Metabolism	Halophilic archaea and their potential to generate renewable fuels and chemicals.	Kasirajan L, Maupin-Furlow JA.	Biotechnol Bioeng	10.1002/bit.27639	2021
	Characterizing the DNA Methyltransferases of Haloferax volcanii via Bioinformatics, Gene Deletion, and SMRT Sequencing.	Ouellette M, Gogarten JP, Lajoie J, Makkay AM, Papke RT.	Genes (Basel)	10.3390/genes9030129	2018
	Deciphering the Structural Basis of High Thermostability of Dehalogenase from Psychrophilic Bacterium Marinobacter sp. ELB17.	Chrast L, Tratsiak K, Planas-Iglesias J, Daniel L, Prudnikova T, Brezovsky J, Bednar D, Kuta Smatanova I, Chaloupkova R, Damborsky J.	Microorganisms	10.3390/microorganisms7110498	2019
Metabolism	Dihydroxyacetone metabolism in Haloferax volcanii.	Ouellette M, Makkay AM, Papke RT.	Front Microbiol	10.3389/fmicb.2013.00376	2013
Enzymology	Crystallization and preliminary X-ray analysis of binary and ternary complexes of Haloferax mediterranei glucose dehydrogenase.	Esclapez J, Britton KL, Baker PJ, Fisher M, Pire C, Ferrer J, Bonete MJ, Rice DW.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309105019949	2005
Genetics	Bipyrimidine Signatures as a Photoprotective Genome Strategy in G + C-rich Halophilic Archaea.	Jones DL, Baxter BK.	Life (Basel)	10.3390/life6030037	2016
Enzymology	Exopolysaccharides from Marine and Marine Extremophilic Bacteria: Structures, Properties, Ecological Roles and Applications.	Casillo A, Lanzetta R, Parrilli M, Corsaro MM.	Mar Drugs	10.3390/md16020069	2018
Transcriptome	Sequencing of seven haloarchaeal genomes reveals patterns of genomic flux.	Lynch EA, Langille MG, Darling A, Wilbanks EG, Haltiner C, Shao KS, Starr MO, Teiling C, Harkins TT, Edwards RA, Eisen JA, Facciotti MT.	PLoS One	10.1371/journal.pone.0041389	2012
Pathogenicity	Inhibition of the growth of Bacillus subtilis DSM10 by a newly discovered antibacterial protein from the soil metagenome.	O'Mahony MM, Henneberger R, Selvin J, Kennedy J, Doohan F, Marchesi JR, Dobson AD.	Bioengineered	10.1080/21655979.2015.1018493	2015
Metabolism	Genetic and biochemical characterization of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthase in Haloferax mediterranei.	Lu Q, Han J, Zhou L, Zhou J, Xiang H.	J Bacteriol	10.1128/jb.00134-08	2008
	Cellular and Genomic Properties of Haloferax gibbonsii LR2-5, the Host of Euryarchaeal Virus HFTV1.	Tittes C, Schwarzer S, Pfeiffer F, Dyall-Smith M, Rodriguez-Franco M, Oksanen HM, Quax TEF.	Front Microbiol	10.3389/fmicb.2021.625599	2021
Phylogeny	Polyhydroxyalkanoates (PHAs) as Biomaterials in Tissue Engineering: Production, Isolation, Characterization.	Miu DM, Eremia MC, Moscovici M.	Materials (Basel)	10.3390/ma15041410	2022
	Cis-regulatory evolution in prokaryotes revealed by interspecific archaeal hybrids.	Artieri CG, Naor A, Turgeman-Grott I, Zhou Y, York R, Gophna U, Fraser HB.	Sci Rep	10.1038/s41598-017-04278-4	2017
	Phylogeny and Taxonomy of Archaea: A Comparison of the Whole-Genome-Based CVTree Approach with 16S rRNA Sequence Analysis.	Zuo G, Xu Z, Hao B.	Life (Basel)	10.3390/life5010949	2015
	Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.	Corral P, Amoozegar MA, Ventosa A.	Mar Drugs	10.3390/md18010033	2019
Phylogeny	A Real-Time PCR Method to Detect the Population Level of Halovirus SNJ1.	Mei Y, He C, Deng W, Ba D, Yang M, Zhang J, Zhang S, Shen P, Chen X.	PLoS One	10.1371/journal.pone.0155642	2016
	Reprocessing of side-streams towards obtaining valuable bacterial metabolites.	Piwowarek K, Lipinska E, Kieliszek M.	Appl Microbiol Biotechnol	10.1007/s00253-023-12458-8	2023
Metabolism	GlpR Is a Direct Transcriptional Repressor of Fructose Metabolic Genes in Haloferax volcanii.	Martin JH, Sherwood Rawls K, Chan JC, Hwang S, Martinez-Pastor M, McMillan LJ, Prunetti L, Schmid AK, Maupin-Furlow JA.	J Bacteriol	10.1128/jb.00244-18	2018
	Isolation, sequence, and expression of the gene encoding halocin H4, a bacteriocin from the halophilic archaeon Haloferax mediterranei R4.	Cheung J, Danna KJ, O'Connor EM, Price LB, Shand RF.	J Bacteriol	10.1128/jb.179.2.548-551.1997	1997
Genetics	Genomic stability in the archaeae Haloferax volcanii and Haloferax mediterranei.	Lopez-Garcia P, St Jean A, Amils R, Charlebois RL.	J Bacteriol	10.1128/jb.177.5.1405-1408.1995	1995
	The Ribbon-Helix-Helix Domain Protein CdrS Regulates the Tubulin Homolog ftsZ2 To Control Cell Division in Archaea.	Darnell CL, Zheng J, Wilson S, Bertoli RM, Bisson-Filho AW, Garner EC, Schmid AK.	mBio	10.1128/mbio.01007-20	2020
Metabolism	Molecular characterization of the phaECHm genes, required for biosynthesis of poly(3-hydroxybutyrate) in the extremely halophilic archaeon Haloarcula marismortui.	Han J, Lu Q, Zhou L, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.00953-07	2007
Metabolism	Genomic organization of the halophilic archaeon Haloferax mediterranei: physical map of the chromosome.	Lopez-Garcia P, Abad JP, Smith C, Amils R.	Nucleic Acids Res	10.1093/nar/20.10.2459	1992
Transcriptome	Population and genomic analysis of the genus Halorubrum.	Fullmer MS, Soucy SM, Swithers KS, Makkay AM, Wheeler R, Ventosa A, Gogarten JP, Papke RT.	Front Microbiol	10.3389/fmicb.2014.00140	2014
	Effects of Culture Conditions on Poly(beta-Hydroxybutyric Acid) Production by Haloferax mediterranei.	Lillo JG, Rodriguez-Valera F.	Appl Environ Microbiol	10.1128/aem.56.8.2517-2521.1990	1990
Enzymology	Further thermal characterization of an aspartate aminotransferase from a halophilic organism.	Muriana FJ, Alvarez-Ossorio MC, Relimpio AM.	Biochem J	10.1042/bj2980465	1994
	An ancient autoproteolytic domain found in GAIN, ZU5 and Nucleoporin98.	Liao Y, Pei J, Cheng H, Grishin NV.	J Mol Biol	10.1016/j.jmb.2014.10.011	2014
	Production of an Extracellular Polysaccharide by Haloferax mediterranei.	Anton J, Meseguer I, Rodriguez-Valera F.	Appl Environ Microbiol	10.1128/aem.54.10.2381-2386.1988	1988
Phylogeny	Quantifying homologous replacement of loci between haloarchaeal species.	Williams D, Gogarten JP, Papke RT.	Genome Biol Evol	10.1093/gbe/evs098	2012
	Transformation of members of the genus Haloarcula with shuttle vectors based on Halobacterium halobium and Haloferax volcanii plasmid replicons.	Cline SW, Doolittle WF.	J Bacteriol	10.1128/jb.174.3.1076-1080.1992	1992
Phylogeny	Phylogenetic analyses of some extremely halophilic archaea isolated from Dead Sea water, determined on the basis of their 16S rRNA sequences.	Arahal DR, Dewhirst FE, Paster BJ, Volcani BE, Ventosa A.	Appl Environ Microbiol	10.1128/aem.62.10.3779-3786.1996	1996
	Emergent Approaches to Efficient and Sustainable Polyhydroxyalkanoate Production.	Bedade DK, Edson CB, Gross RA.	Molecules	10.3390/molecules26113463	2021
Phylogeny	PH1: an archaeovirus of Haloarcula hispanica related to SH1 and HHIV-2.	Porter K, Tang SL, Chen CP, Chiang PW, Hong MJ, Dyall-Smith M.	Archaea	10.1155/2013/456318	2013
Metabolism	A complex of Cas proteins 5, 6, and 7 is required for the biogenesis and stability of clustered regularly interspaced short palindromic repeats (crispr)-derived rnas (crrnas) in Haloferax volcanii.	Brendel J, Stoll B, Lange SJ, Sharma K, Lenz C, Stachler AE, Maier LK, Richter H, Nickel L, Schmitz RA, Randau L, Allers T, Urlaub H, Backofen R, Marchfelder A.	J Biol Chem	10.1074/jbc.m113.508184	2014
	Heavily Armed Ancestors: CRISPR Immunity and Applications in Archaea with a Comparative Analysis of CRISPR Types in Sulfolobales.	Zink IA, Wimmer E, Schleper C.	Biomolecules	10.3390/biom10111523	2020
	Halocin S8: a 36-amino-acid microhalocin from the haloarchaeal strain S8a.	Price LB, Shand RF.	J Bacteriol	10.1128/jb.182.17.4951-4958.2000	2000
	Lysis of halobacteria in bacto-peptone by bile acids.	Kamekura M, Oesterhelt D, Wallace R, Anderson P, Kushner DJ.	Appl Environ Microbiol	10.1128/aem.54.4.990-995.1988	1988
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
	Gene cloning and heterologous synthesis of a haloalkaliphilic extracellular protease of Natrialba magadii (Nep).	De Castro RE, Ruiz DM, Gimenez MI, Silveyra MX, Paggi RA, Maupin-Furlow JA.	Extremophiles	10.1007/s00792-008-0174-6	2008
	Static Magnetic Field Increases Polyhydroxyalkanoates Biosynthesis in Haloferax mediterranei: Parameter Optimization and Mechanistic Insights from Metabolomics.	Gao ZL, Cui YW.	Polymers (Basel)	10.3390/polym17091190	2025
	Improving poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis with the construction of a genome-scale metabolic model for Haloferax mediterranei	Gao Q, Zhang L, Huang W, Zhang Y, Hewage R, Zhou M, Xu Y, Han Y, Yu J, Wang Z, Xie Z, Han J, Xiang H.	International Journal of Biological Macromolecules.		2025
Enzymology	Maintenance energy-driven polyhydroxyalkanoates production from food waste digestate by Haloferax mediterranei.	Zhang X, Wang J, Hassanein A, An Z, Lansing S, Wang ZW.	Bioresour Technol	10.1016/j.biortech.2025.132952	2025
Genetics	Improving poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis with the construction of a genome-scale metabolic model for Haloferax mediterranei.	Gao Q, Zhang L, Huang W, Zhang Y, Hewage R, Zhou M, Xu Y, Han Y, Yu J, Wang Z, Xie Z, Han J, Xiang H.	Int J Biol Macromol	10.1016/j.ijbiomac.2025.146335	2025
Cultivation	Expanding time-resolved ICP-MS capabilities for characterizing cells and biogenic nanoparticles in hypersaline media.	Guijarro-Ramirez N, Gonzalez-de Vega R, Saez-Zamacona I, Gras L, Martinez-Espinosa RM, Clases D, Grindlay G.	Anal Chim Acta	10.1016/j.aca.2025.344731	2025
	Promoter engineering for enhanced poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) production in Haloferax mediterranei.	Zhou M, Xu Y, Li J, Han Y, Yu H, Qi L, Chen J, Xiang H, Han J.	Int J Biol Macromol	10.1016/j.ijbiomac.2025.143237	2025
	Enhancement of 3-hydroxyvalerate fraction in poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei fed with food waste pretreated via arrested anaerobic digestion integrated with microbial electrolysis cells.	Zhang X, Amradi NK, Moore M, Hassanein A, Mickol RL, McCoy EL, Eddie BJ, Shepard JS, Wang J, Lansing S, Yates MD, Kim YT, Wang ZW.	Bioresour Technol	10.1016/j.biortech.2025.132536	2025
Biotechnology	Haloferax and the Haloferacaceae: Potential role in bioindustry.	Griffiths DB, Tiwari RP, Murphy DV, Scott C.	Biotechnol Adv	10.1016/j.biotechadv.2025.108666	2025
	Bioconversion of dairy co-products to polyhydroxyalkanoates by halophilic microbes with salts and nutrients recycling.	Wang K, M Hobby A, Chio A, E El Mashad H, Zhang R.	Bioresour Technol	10.1016/j.biortech.2025.132228	2025
	CRISPR-based gene knockout in the model haloarchaeon Haloferax mediterranei.	Gong M, Ding Y, Jin Y, Zhao S, Jiang X, Shao S, Chen S.	FEMS Microbiol Lett	10.1093/femsle/fnaf096	2025
Proteome	Determination of in cellulo proteome molecular dynamics in different halophilic Archaea.	Carre L, Natali F, Zaccai G, Cumaku V, Franzetti B.	J R Soc Interface	10.1098/rsif.2024.0630	2025
	Rapid rewiring of an archaeal transcription factor function via flexible cis-trans interactions.	Pastor MM, Darnell CL, Vreugdenhil A, Schmid AK.	Mol Biol Cell	10.1091/mbc.e24-11-0505	2025
	Effects of magnetic field exposure patterns on polyhydroxyalkanoates synthesis by Haloferax mediterranei at extreme hypersaline context: Carbon distribution and salt tolerance.	Yan HJ, Cui YW, Chen S, Wang X.	Int J Biol Macromol	10.1016/j.ijbiomac.2024.137769	2024
	Characterization of biogenic selenium nanoparticles in hypersaline media by single particle inductively coupled plasma mass spectrometry: Haloferax mediterranei case.	Guijarro-Ramirez N, Saez-Zamacona I, Torregrosa D, Grindlay G, Gras L, Pire C, Mora J, Martinez-Espinosa RM.	Anal Chim Acta	10.1016/j.aca.2024.343453	2025
	Long-term effects of cycle time and volume exchange ratio on poly(3-hydroxybutyrate-co-3-hydroxyvalerate) production from food waste digestate by Haloferax mediterranei cultivated in sequencing batch reactors for 450 days.	Zhang X, An Z, Wang J, Lansing S, Kumar Amradi N, Sazzadul Haque M, Wang ZW.	Bioresour Technol	10.1016/j.biortech.2024.131771	2025
	Bioplastic Production from Agri-Food Waste through the Use of Haloferax mediterranei: A Comprehensive Initial Overview.	Longo A, Fanelli F, Villano M, Montemurro M, Rizzello CG.	Microorganisms	10.3390/microorganisms12061038	2024
	Advances in polyhydroxyalkanoate (PHA) production from renewable waste materials using halophilic microorganisms: A comprehensive review.	Ben Abdallah M, Saadaoui I, Al-Ghouti MA, Zouari N, Hahladakis JN, Chamkha M, Sayadi S.	Sci Total Environ	10.1016/j.scitotenv.2025.178452	2025
	Global Lrp regulator protein from Haloferax mediterranei: Transcriptional analysis and structural characterization.	Matarredona L, Garcia-Bonete MJ, Guio J, Camacho M, Fillat MF, Esclapez J, Bonete MJ.	Int J Biol Macromol	10.1016/j.ijbiomac.2024.129541	2024
	Toxicity Assessment and Bioremediation of Deep Eutectic Solvents by Haloferax mediterranei: A Step toward Sustainable Circular Chemistry.	Martinez G, Guillena G, Martinez-Espinosa RM.	ChemSusChem	10.1002/cssc.202500825	2025
	Production of polyhydroxyalkanoates from hydrolysed rapeseed meal by Haloferax mediterranei.	Khamplod T, Wongsirichot P, Winterburn J.	Bioresour Technol	10.1016/j.biortech.2023.129541	2023
	Food wastes for bioproduct production and potential strategies for high feedstock variability.	Wongsirichot P, Barroso-Ingham B, Hamilton A, Parroquin Gonzalez M, Romero Jimenez R, Hoeven R, Winterburn J.	Waste Manag	10.1016/j.wasman.2024.05.027	2024
Biotechnology	Comparative genomics of the highly halophilic Haloferacaceae.	Griffiths DB, Tiwari RP, Murphy DV, Scott C.	Sci Rep	10.1038/s41598-024-78438-8	2024
	Advanced Strategies for Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) Production: PHA Synthase Homologous Overexpression in the Extremophile Haloferax mediterranei.	Simica A, Segovia Y, Navarro-Sempere A, Martinez-Espinosa RM, Pire C.	Mar Drugs	10.3390/md23040166	2025
Enzymology	Pharmaceutical applications of halophilic enzymes.	Yavari-Bafghi M, Amoozegar MA.	Heliyon	10.1016/j.heliyon.2025.e42754	2025
	Genetic identification of acetyl-CoA synthetases involved in acetate activation in Haloferax mediterranei.	Mitra R, Xu Y, Lin L, Guo J, Xu T, Zhou M, Guo F, Li H, Xiang H, Han J.	Appl Environ Microbiol	10.1128/aem.01843-24	2025
	Lrp as a potential transcriptional regulator involved in stress response in Haloferax mediterranei.	Matarredona L, Camacho M, Bautista V, Bonete MJ, Esclapez J.	Biochimie	10.1016/j.biochi.2023.01.012	2023
	Production of Polyhydroxyalkanoates for Biodegradable Food Packaging Applications Using Haloferax mediterranei and Agrifood Wastes.	Atares L, Chiralt A, Gonzalez-Martinez C, Vargas M.	Foods	10.3390/foods13060950	2024
	Effects of chaotropic salts on global proteome stability in halophilic archaea: Implications for life signatures on Mars.	Carre L, Gonzalez D, Girard E, Franzetti B.	Environ Microbiol	10.1111/1462-2920.16451	2023
	Effect of levulinic acid on production of polyhydroxyalkanoates from food waste by Haloferax mediterranei.	Priya A, Hathi Z, Haque MA, Kumar S, Kumar A, Singh E, Lin CSK.	Environ Res	10.1016/j.envres.2022.114001	2022
	Adaptive traits for chitin utilization in the saprotrophic aquatic chytrid fungus Rhizoclosmatium globosum.	Chrismas N, Bird K, Laundon D, Lieng C, Hesketh-Best P, Cunliffe M.	Proc Biol Sci	10.1098/rspb.2025.0337	2025
	Potassium binding by carbonyl clusters, halophilic adaptation and catalysis of Haloferax mediterranei D-2-hydroxyacid dehydrogenase.	Domenech J, Pramanpol N, Bisson C, Sedelnikova SE, Barrett JR, Dakhil AAAB, Mykhaylyk V, Abdelhameed AS, Harding SE, Rice DW, Baker PJ, Ferrer J.	Commun Biol	10.1038/s42003-025-08587-7	2025
	Halophyte biorefinery for polyhydroxyalkanoates production from Ulva sp. Hydrolysate with Haloferax mediterranei in pneumatically agitated bioreactors and ultrasound harvesting.	Ghosh S, Coons J, Yeager C, Halley P, Chemodanov A, Belgorodsky B, Gozin M, Chen GQ, Golberg A.	Bioresour Technol	10.1016/j.biortech.2021.125964	2022
	Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies.	Giani M, Pire C, Martinez-Espinosa RM.	Mar Drugs	10.3390/md22040167	2024
	Evaluating haloarchaeal culture media for ultrahigh-molecular-weight polyhydroxyalkanoate biosynthesis by Haloferax mediterranei.	Sato S, Ino K, Ushimaru K, Wada K, Saika A, Fukuoka T, Ohshiman K, Morita T.	Appl Microbiol Biotechnol	10.1007/s00253-021-11508-3	2021
	Understanding the tolerance of halophilic archaea to stress landscapes.	Matarredona L, Zafrilla B, Camacho M, Bonete MJ, Esclapez J.	Environ Microbiol Rep	10.1111/1758-2229.70039	2024
Genetics	Bacterioruberin extract from Haloferax mediterranei induces apoptosis and cell cycle arrest in myeloid leukaemia cell lines.	Baeza-Morales A, Pascual-Garcia S, Martinez-Peinado P, Navarro-Sempere A, Segovia Y, Medina-Garcia M, Pujalte-Satorre C, Garcia MM, Martinez-Espinosa RM, Sempere-Ortells JM.	Sci Rep	10.1038/s41598-025-06999-3	2025
Transcriptome	Transcriptomic profiling of haloarchaeal denitrification through RNA-Seq analysis.	Miralles-Robledillo JM, Martinez-Espinosa RM, Pire C.	Appl Environ Microbiol	10.1128/aem.00571-24	2024
Metabolism	Functional analysis of Lsm protein under multiple stress conditions in the extreme haloarchaeon Haloferax mediterranei.	Paya G, Bautista V, Camacho M, Bonete MJ, Esclapez J.	Biochimie	10.1016/j.biochi.2021.05.002	2021
	Analysis of Lsm Protein-Mediated Regulation in the Haloarchaeon Haloferax mediterranei.	Paya G, Bautista V, Pastor-Soler S, Camacho M, Esclapez J, Bonete MJ.	Int J Mol Sci	10.3390/ijms25010580	2024
	Biosynthesized poly(3-hydroxybutyrate-co-3-hydroxyvalerate) as biocompatible microcapsules with extended release for busulfan and montelukast.	Ibrahim MI, Alsafadi D, Safi E, Alenazi E, Aboulsoud M, Hussein MA, Alamry KA.	Int J Biol Macromol	10.1016/j.ijbiomac.2022.05.181	2022
Biotechnology	Halophilic archaea as tools for bioremediation technologies.	Martinez-Espinosa RM.	Appl Microbiol Biotechnol	10.1007/s00253-024-13241-z	2024
	Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications.	Moopantakath J, Imchen M, Anju VT, Busi S, Dyavaiah M, Martinez-Espinosa RM, Kumavath R.	Front Microbiol	10.3389/fmicb.2023.1113540	2023
Metabolism	The metabolic pathways of polyhydroxyalkanoates and exopolysaccharides synthesized by Haloferax mediterranei in response to elevated salinity.	Pacholak A, Gao ZL, Gong XY, Kaczorek E, Cui YW.	J Proteomics	10.1016/j.jprot.2020.104065	2021
	Evaluation of Haloferax mediterranei Strain R4 Capabilities for Cadmium Removal from Brines.	Saez-Zamacona I, Grindlay G, Martinez-Espinosa RM.	Mar Drugs	10.3390/md21020072	2023
	Deletion of the pps-like gene activates the cryptic phaC genes in Haloferax mediterranei.	Chen J, Mitra R, Xiang H, Han J.	Appl Microbiol Biotechnol	10.1007/s00253-020-10898-0	2020
	Polyhydroxyalkanoates and biochar from green macroalgal Ulva sp. biomass subcritical hydrolysates: Process optimization and a priori economic and greenhouse emissions break-even analysis.	Ghosh S, Greiserman S, Chemodanov A, Slegers PM, Belgorodsky B, Epstein M, Kribus A, Gozin M, Chen GQ, Golberg A.	Sci Total Environ	10.1016/j.scitotenv.2021.145281	2021
	Exploring the antimicrobial potential of two haloarchaeal strains belonging to the genera Halopiger and Natrialba isolated from the Algerian Sahara	Quadri I, Hassani I, Hacene H.	Iran J Microbiol		2025
	The lanthipeptide biosynthetic clusters of the domain Archaea.	Castro I, Costa H, Turgeman-Grott I, Allers T, Mendo S, Caetano T.	Microbiol Res	10.1016/j.micres.2021.126884	2021
Metabolism	New proposal of nitrogen metabolism regulation by small RNAs in the extreme halophilic archaeon Haloferax mediterranei.	Paya G, Bautista V, Camacho M, Bonete MJ, Esclapez J.	Mol Genet Genomics	10.1007/s00438-020-01659-9	2020
	Essentiality of the glnA gene in Haloferax mediterranei: gene conversion and transcriptional analysis.	Rodriguez-Herrero V, Paya G, Bautista V, Vegara A, Cortes-Molina M, Camacho M, Esclapez J, Bonete MJ.	Extremophiles	10.1007/s00792-020-01169-x	2020
	Classification and Identification of Archaea Using Single-Cell Raman Ejection and Artificial Intelligence: Implications for Investigating Uncultivated Microorganisms.	Wang Y, Xu J, Cui D, Kong L, Chen S, Xie W, Zhang C.	Anal Chem	10.1021/acs.analchem.1c03495	2021
Metabolism	In Silico Analysis of the Enzymes Involved in Haloarchaeal Denitrification.	Bernabeu E, Miralles-Robledillo JM, Giani M, Valdes E, Martinez-Espinosa RM, Pire C.	Biomolecules	10.3390/biom11071043	2021
	Carbon Source Influences Antioxidant, Antiglycemic, and Antilipidemic Activities of Haloferax mediterranei Carotenoid Extracts.	Giani M, Gervasi L, Loizzo MR, Martinez-Espinosa RM.	Mar Drugs	10.3390/md20110659	2022
	Utilizing the crop waste of date palm fruit to biosynthesize polyhydroxyalkanoate bioplastics with favorable properties.	Alsafadi D, Ibrahim MI, Alamry KA, Hussein MA, Mansour A.	Sci Total Environ	10.1016/j.scitotenv.2020.139716	2020
	Haloarchaeal carotenoids exert an in vitro antiproliferative effect on human breast cancer cell lines.	Giani M, Montoyo-Pujol YG, Peiro G, Martinez-Espinosa RM.	Sci Rep	10.1038/s41598-023-34419-x	2023
	Excavation of acoustic nanostructures biosynthesis gene clusters by combinatorial strategy.	Liu W, Liu T, Huang S, Yan F, Liu JZ.	Adv Biotechnol (Singap)	10.1007/s44307-025-00069-5	2025
	A Spotlight on Archaea in Humans, Livestock and Poultry: A Review.	Salahi A, Abd El-Ghany WA.	Vet Med Sci	10.1002/vms3.70263	2025
	A Polyhydroxybutyrate-Supported Xerogel Biosensor for Rapid BOD Mapping and Integration with Satellite Data for Regional Water Quality Assessment.	Gurkin G, Efremov A, Koryakina I, Perchikov R, Kharkova A, Medvedeva A, Fabiano B, Reverberi AP, Arlyapov V.	Gels	10.3390/gels11110849	2025
	Exploring the structural landscape of universal stress proteins in Archaea.	Matarredona L, Garcia-Bonete MJ, Zafrilla B, Esclapez J.	World J Microbiol Biotechnol	10.1007/s11274-025-04439-y	2025
	Analysis of Polyhydroxyalkanoates Granules in Haloferax mediterranei by Double-Fluorescence Staining with Nile Red and SYBR Green by Confocal Fluorescence Microscopy.	Canovas V, Garcia-Chumillas S, Monzo F, Simo-Cabrera L, Fernandez-Ayuso C, Pire C, Martinez-Espinosa RM.	Polymers (Basel)	10.3390/polym13101582	2021
	Differences in homologous recombination and maintenance of heteropolyploidy between Haloferax volcanii and Haloferax mediterranei.	Dattani A, Sharon I, Shtifman-Segal E, Robinzon S, Gophna U, Allers T, Altman-Price N.	G3 (Bethesda)	10.1093/g3journal/jkac306	2023
Metabolism	Macroalgal biomass subcritical hydrolysates for the production of polyhydroxyalkanoate (PHA) by Haloferax mediterranei.	Ghosh S, Gnaim R, Greiserman S, Fadeev L, Gozin M, Golberg A.	Bioresour Technol	10.1016/j.biortech.2018.09.108	2019
	Tailoring 3HV Fraction in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Azotobacter vinelandii Through Oxygen and Carbon Limitation in Continuous Cultures.	Perez A, Garcia A, Urtuvia V, Pena C, Diaz-Barrera A.	Polymers (Basel)	10.3390/polym17192578	2025
Genetics	Study on the correlation between the dominant microflora and the main flavor substances in the fermentation process of cigar tobacco leaves.	Wu X, Hu Y, Wang Q, Liu J, Fang S, Huang D, Pang X, Cao J, Gao Y, Ning Y.	Front Microbiol	10.3389/fmicb.2023.1267447	2023
	Harnessing Waste Bread: From Potential Use in Microbial Growth and Enzyme Production to Techno-Economic Assessment.	Ben Mabrouk S, Ben Hadj Hmida B, Sallami W, Dhaouadi S, Varzakas T, Smaoui S.	Microorganisms	10.3390/microorganisms13071571	2025
Metabolism	Denitrifying haloarchaea within the genus Haloferax display divergent respiratory phenotypes, with implications for their release of nitrogenous gases.	Torregrosa-Crespo J, Pire C, Martinez-Espinosa RM, Bergaust L.	Environ Microbiol	10.1111/1462-2920.14474	2019
	Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography.	Chmelova K, Gao T, Polak M, Schenkmayerova A, Croll TI, Shaikh TR, Skarupova J, Chaloupkova R, Diederichs K, Read RJ, Damborsky J, Novacek J, Marek M.	Protein Sci	10.1002/pro.4751	2023
Metabolism	Production of the copolymer poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with varied composition using different nitrogen sources with Haloferax mediterranei.	Ferre-Guell A, Winterburn J.	Extremophiles	10.1007/s00792-017-0964-9	2017
Metabolism	Optimization of nitrogen source supply for enhanced biosynthesis and quality of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by extremely halophilic archaeon Haloferax mediterranei.	Alsafadi D, Al-Mashaqbeh O, Mansour A, Alsaad M.	Microbiologyopen	10.1002/mbo3.1055	2020
	Perspectives of RNAi, CUADb and CRISPR/Cas as Innovative Antisense Technologies for Insect Pest Control: From Discovery to Practice.	Kumar H, Gal'chinsky N, Sweta V, Negi N, Filatov R, Chandel A, Ali J, Oberemok V, Laikova K.	Insects	10.3390/insects16070746	2025
	Unveiling the repressive mechanism of a PPS-like regulator (PspR) in polyhydroxyalkanoates biosynthesis network.	Chen J, Cui Y, Zhang S, Wu B, Han J, Xiang H.	Appl Microbiol Biotechnol	10.1007/s00253-024-13100-x	2024
Metabolism	Systematic Analysis of Lysine Acetylation in the Halophilic Archaeon Haloferax mediterranei.	Liu J, Wang Q, Jiang X, Yang H, Zhao D, Han J, Luo Y, Xiang H.	J Proteome Res	10.1021/acs.jproteome.7b00222	2017
Metabolism	Biosynthesis and Characterization of Polyhydroxyalkanoates with Controlled Composition and Microstructure.	Ferre-Guell A, Winterburn J.	Biomacromolecules	10.1021/acs.biomac.7b01788	2018
	Archaeal Tubulin-like Proteins Modify Cell Shape in Haloferax volcanii during Early Biofilm Development.	Cooper A, Makkay AM, Papke RT.	Genes (Basel)	10.3390/genes14101861	2023
Genetics	The biosynthesis mechanism of bacterioruberin in halophilic archaea revealed by genome and transcriptome analysis.	Ma Y, Sun Z, Yang H, Xie W, Song M, Zhang B, Sui L.	Appl Environ Microbiol	10.1128/aem.00540-24	2024
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	CRISPR-Cas Systems in the Fight Against Antimicrobial Resistance: Current Status, Potentials, and Future Directions.	Ahmed MM, Kayode HH, Okesanya OJ, Ukoaka BM, Eshun G, Mourid MR, Adigun OA, Ogaya JB, Mohamed ZO, Lucero-Prisno DE.	Infect Drug Resist	10.2147/idr.s494327	2024
	Quorum-driven microbial consortium for Bioplastic production from agro-waste.	Crespo-Roche D, Herraez M, Guerrero-Flores J, Martinez MJ, Louie K, Northen T, Prieto A, Barriuso J.	ACS Sustain Chem Eng	10.1021/acssuschemeng.5c05453	2025
	Replication Origin Deletion Enhances Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) Synthesis in Haloarchaea.	Yang H, Chen J, Mitra R, Xue Q, Xiang H, Han J.	Microbiol Spectr	10.1128/spectrum.02149-22	2022
	Exploring the Molecular Machinery of Denitrification in Haloferax mediterranei Through Proteomics.	Torregrosa-Crespo J, Pire C, Richardson DJ, Martinez-Espinosa RM.	Front Microbiol	10.3389/fmicb.2020.605859	2020
	Production of the Polyhydroxyalkanoate PHBV from Ricotta Cheese Exhausted Whey by Haloferax mediterranei Fermentation.	Raho S, Carofiglio VE, Montemurro M, Miceli V, Centrone D, Stufano P, Schioppa M, Pontonio E, Rizzello CG.	Foods	10.3390/foods9101459	2020
Metabolism	Analysis of Haloferax mediterranei Lrp Transcriptional Regulator.	Matarredona L, Camacho M, Garcia-Bonete MJ, Esquerra B, Zafrilla B, Esclapez J, Bonete MJ.	Genes (Basel)	10.3390/genes12060802	2021
	A review on microbes mediated resource recovery and bioplastic (polyhydroxyalkanoates) production from wastewater.	Ahuja V, Singh PK, Mahata C, Jeon JM, Kumar G, Yang YH, Bhatia SK.	Microb Cell Fact	10.1186/s12934-024-02430-0	2024
	A promising antimicrobial bionanocomposite based poly(3-hydroxybutyrate-co-3-hydroxyvalerate) reinforced silver doped zinc oxide nanoparticles.	Ibrahim MI, Alsafadi D, Alamry KA, Oves M, Alosaimi AM, Hussein MA.	Sci Rep	10.1038/s41598-022-17470-y	2022
Metabolism	A one-stage cultivation process for the production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) from olive mill wastewater by Haloferax mediterranei.	Alsafadi D, Al-Mashaqbeh O.	N Biotechnol	10.1016/j.nbt.2016.05.003	2017
	Characterization of Polyhydroxybutyrate, PHB, Synthesized by Newly Isolated Haloarchaea Halolamina spp.	Hagagy N, Saddiq AA, Tag HM, Selim S, AbdElgawad H, Martinez-Espinosa RM.	Molecules	10.3390/molecules27217366	2022
Metabolism	Novel Glutamate-Putrescine Ligase Activity in Haloferax mediterranei: A New Function for glnA-2 Gene.	Rodriguez-Herrero V, Peris A, Camacho M, Bautista V, Esclapez J, Bonete MJ.	Biomolecules	10.3390/biom11081156	2021
Enzymology	Haloferax mediterranei, an Archaeal Model for Denitrification in Saline Systems, Characterized Through Integrated Physiological and Transcriptional Analyses.	Torregrosa-Crespo J, Pire C, Bergaust L, Martinez-Espinosa RM.	Front Microbiol	10.3389/fmicb.2020.00768	2020
Genetics	Comprehensive whole metagenomics analysis uncovers microbial community and resistome variability across anthropogenically contaminated soils in urban and suburban areas of Tamil Nadu, India.	Vasanthrao R, Nidhin IK, Taj Z, Chattopadhyay I.	Front Microbiol	10.3389/fmicb.2025.1649872	2025
	CRISPR-Cas13a as a next-generation tool for rapid and precise plant RNA virus diagnostics.	Karimi M, Ghorbani A, Niazi A, Rostami M, Tahmasebi A.	Plant Methods	10.1186/s13007-025-01401-9	2025
Metabolism	Effects of combined magnetic fields on bacteria Rhodospirillum rubrum VKM B-1621.	Khokhlova G, Abashina T, Belova N, Panchelyuga V, Petrov A, Abreu F, Vainshtein M.	Bioelectromagnetics	10.1002/bem.22130	2018
	Fabrication and Evaluation of Polyhydroxyalkanoate-Based Nanoparticles for Curcumin Delivery in Biomedical Applications.	Sha'at F, Miu D, Eremia MC, Neagu G, Albulescu A, Albulescu R, Deaconu M, Vladu MG, Pavaloiu RD.	Molecules	10.3390/molecules30061216	2025
	Optimization and characterization of polyhydroxybutyrate produced by Halomonas meridiana using orange peel waste.	Hendy MH, Shehabeldine AM, Hashem AH, El-Sayed AF, El-Sheikh HH.	BMC Microbiol	10.1186/s12866-025-04007-2	2025
	The Survival of Haloferax mediterranei under Stressful Conditions.	Matarredona L, Camacho M, Zafrilla B, Bravo-Barrales G, Esclapez J, Bonete MJ.	Microorganisms	10.3390/microorganisms9020336	2021
	Optimization and characterization of polyhydroxybutyrate produced by Vreelandella piezotolerans using orange peel waste.	Hendy MH, Shehabeldine AM, Hashem AH, El-Sayed AF, El-Sheikh HH.	Sci Rep	10.1038/s41598-025-10899-x	2025
	Carotenoids as a Protection Mechanism against Oxidative Stress in Haloferax mediterranei.	Giani M, Martinez-Espinosa RM.	Antioxidants (Basel)	10.3390/antiox9111060	2020
Metabolism	Production of Polyhydroxyalkanoates in Unsterilized Hyper-Saline Medium by Halophiles Using Waste Silkworm Excrement as Carbon Source.	Cai S, Wu Y, Li Y, Yang S, Liu Z, Ma Y, Lv J, Shao Y, Jia H, Zhao Y, Cai L.	Molecules	10.3390/molecules26237122	2021
Metabolism	Mass production of C50 carotenoids by Haloferax mediterranei in using extruded rice bran and starch under optimal conductivity of brined medium.	Chen CW, Hsu SH, Lin MT, Hsu YH.	Bioprocess Biosyst Eng	10.1007/s00449-015-1471-y	2015
Metabolism	Conversion of cheese whey into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by Haloferax mediterranei.	Pais J, Serafim LS, Freitas F, Reis MA.	N Biotechnol	10.1016/j.nbt.2015.06.001	2016
	Liquid formulation of halo-alkali-thermo-tolerant rhizobacteria for enhanced growth of mung bean crops under abiotic stresses.	Vaghela NR, Gohel SD.	Sci Rep	10.1038/s41598-025-05883-4	2025
	Optimization of Growth and Carotenoid Production by Haloferax mediterranei Using Response Surface Methodology.	Montero-Lobato Z, Ramos-Merchante A, Fuentes JL, Sayago A, Fernandez-Recamales A, Martinez-Espinosa RM, Vega JM, Vilchez C, Garbayo I.	Mar Drugs	10.3390/md16100372	2018
	Biosynthesis, characterization, and hemostasis potential of tailor-made poly(3-hydroxybutyrate-co-3-hydroxyvalerate) produced by Haloferax mediterranei.	Han J, Wu LP, Hou J, Zhao D, Xiang H.	Biomacromolecules	10.1021/bm5016267	2015
	Synthesis and Properties of Degradable Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) [P(3HB-co-3HV)] Derived from Waste Fish Oil	Volova T, Kiselev E, Sukovatyi A, Zhila N, Sapozhnikova K, Ipatova N, Shishatskii P.	Polymers (Basel)		2025
Metabolism	Integration of poly-3-(hydroxybutyrate-co-hydroxyvalerate) production by Haloferax mediterranei through utilization of stillage from rice-based ethanol manufacture in India and its techno-economic analysis.	Bhattacharyya A, Jana K, Haldar S, Bhowmic A, Mukhopadhyay UK, De S, Mukherjee J.	World J Microbiol Biotechnol	10.1007/s11274-015-1823-4	2015
	Production, characterization, and antimicrobial activity of polyhydroxyalkanoates synthesized by Bacillus species against skin pathogens.	Manal, Munir F, Safdar W, Abu Bakr Shabbir M, Ahmed S, Navid MT, Ali M, Ahmed I.	RSC Adv	10.1039/d5ra04375a	2025
Metabolism	Transcriptional profiles of Haloferax mediterranei based on nitrogen availability.	Esclapez J, Pire C, Camacho M, Bautista V, Martinez-Espinosa RM, Zafrilla B, Vegara A, Alcaraz LA, Bonete MJ.	J Biotechnol	10.1016/j.jbiotec.2014.11.018	2015
	Microbial weeds in hypersaline habitats: the enigma of the weed-like Haloferax mediterranei.	Oren A, Hallsworth JE.	FEMS Microbiol Lett	10.1111/1574-6968.12571	2014
Genetics	In silico identification of bacterial seaweed-degrading bioplastic producers.	Leadbeater DR, Bruce NC, Tonon T.	Microb Genom	10.1099/mgen.0.000866	2022
Metabolism	Deciphering Pathways for Carotenogenesis in Haloarchaea.	Giani M, Miralles-Robledillo JM, Peiro G, Pire C, Martinez-Espinosa RM.	Molecules	10.3390/molecules25051197	2020
Metabolism	Characterisation of chlorate reduction in the haloarchaeon Haloferax mediterranei.	Martinez-Espinosa RM, Richardson DJ, Bonete MJ.	Biochim Biophys Acta	10.1016/j.bbagen.2014.12.011	2015
Genetics	Scarless gene disruption enabled by a dual-plasmid knockout platform in a clinical infant-derived Bifidobacterium breve strain.	Gao Z, Feng L.	Front Microbiol	10.3389/fmicb.2025.1653505	2025
	Exploring Bacillus amyloliquefaciens strain OM81 for the production of polyhydroxyalkanoate (PHA) bioplastic using olive mill wastewater.	Bacha S, Arous F, Chouikh E, Jaouani A, Gtari M, Charradi K, Attia H, Ghorbel D.	3 Biotech	10.1007/s13205-023-03808-4	2023
	Sugar alcohol degradation in Archaea: uptake and degradation of mannitol and sorbitol in Haloarcula hispanica.	Ortjohann M, Schonheit P.	Extremophiles	10.1007/s00792-024-01365-z	2024
	Identification and characterization of a potential strain for the production of polyhydroxyalkanoate from glycerol.	Xue M, Huang R, Liu W, Cheng J, Liu Y, Zhang J, Wang L, Liu D, Jiang H.	Front Microbiol	10.3389/fmicb.2024.1413120	2024
Pathogenicity	A halocin-H4 mutant Haloferax mediterranei strain retains the ability to inhibit growth of other halophilic archaea.	Naor A, Yair Y, Gophna U.	Extremophiles	10.1007/s00792-013-0579-8	2013
	Cell Wall Glycopolymers of Type Strains from Three Species of the Genus Actinoplanes.	Streshinskaya GM, Sashkov AS, Tul'skaya EM, Senchenkova SN, Dmitrenok AS, Piskunkova NF, Bueva OV, Evtushenko LI.	Biochemistry (Mosc)	10.1134/s0006297916090091	2016
	Cytotoxic effects of halophilic archaea metabolites on ovarian cancer cell lines.	Kowalewicz-Kulbat M, Krawczyk KT, Szulc-Kielbik I, Rykowski S, Denel-Bobrowska M, Olejniczak AB, Locht C, Klink M.	Microb Cell Fact	10.1186/s12934-023-02206-y	2023
	Production and characterization of polyhydroxyalkanoates by Halomonas alkaliantarctica utilizing dairy waste as feedstock.	Mozejko-Ciesielska J, Moraczewski K, Czaplicki S, Singh V.	Sci Rep	10.1038/s41598-023-47489-8	2023
	Survival strategies of Rhinocladiella similis in perchlorate-rich Mars like environments.	Dos Santos A, Schultz J, Souza FO, Ribeiro LR, Verano Braga T, Pilau EJ, Rodrigues-Filho E, Rosado AS.	NPJ Microgravity	10.1038/s41526-025-00475-y	2025
Metabolism	Production of poly-3-(hydroxybutyrate-co-hydroxyvalerate) by Haloferax mediterranei using rice-based ethanol stillage with simultaneous recovery and re-use of medium salts.	Bhattacharyya A, Saha J, Haldar S, Bhowmic A, Mukhopadhyay UK, Mukherjee J.	Extremophiles	10.1007/s00792-013-0622-9	2014
Metabolism	Ferredoxin-dependent glutamate synthase: involvement in ammonium assimilation in Haloferax mediterranei.	Pire C, Martinez-Espinosa RM, Perez-Pomares F, Esclapez J, Bonete MJ.	Extremophiles	10.1007/s00792-013-0606-9	2014
Metabolism	[Development of PhaP-tagged protein expression and purification systems for extremely halophilic archaea ].	Wul J, Cai S, Liu H, Hou J, Han J, Zhou J, Hua X.	Wei Sheng Wu Xue Bao		2014
	Production, optimization, scale up and characterization of polyhydoxyalkanoates copolymers utilizing dairy processing waste.	Patil TD, Ghosh S, Agarwal A, Patel SKS, Tripathi AD, Mahato DK, Kumar P, Slama P, Pavlik A, Haque S.	Sci Rep	10.1038/s41598-024-52098-0	2024
Metabolism	Haloferax mediterranei GlnK proteins are post-translationally modified by uridylylation.	Pedro-Roig L, Camacho M, Bonete MJ.	Proteomics	10.1002/pmic.201200465	2013
	Isolation, characterization and exploring biotechnological potential of halophilic archaea from salterns of western India.	Singh A, Singh AK.	3 Biotech	10.1007/s13205-017-1072-3	2018
	CRISPR/Cas9: an overview of recent developments and applications in cancer research.	Shamjetsabam ND, Rana R, Malik P, Ganguly NK.	Int J Surg	10.1097/js9.0000000000001081	2024
Metabolism	Anaerobic Metabolism in Haloferax Genus: Denitrification as Case of Study.	Torregrosa-Crespo J, Martinez-Espinosa RM, Esclapez J, Bautista V, Pire C, Camacho M, Richardson DJ, Bonete MJ.	Adv Microb Physiol	10.1016/bs.ampbs.2016.02.001	2016
	Mechanism-Based Design of the First GlnA4-Specific Inhibitors.	Purder PL, Meyners C, Krysenko S, Funk J, Wohlleben W, Hausch F.	Chembiochem	10.1002/cbic.202200312	2022
Metabolism	Cu-NirK from Haloferax mediterranei as an example of metalloprotein maturation and exportation via Tat system.	Esclapez J, Zafrilla B, Martinez-Espinosa RM, Bonete MJ.	Biochim Biophys Acta	10.1016/j.bbapap.2013.03.002	2013
Enzymology	Characterization of genes for chitin catabolism in Haloferax mediterranei.	Hou J, Han J, Cai L, Zhou J, Lu Y, Jin C, Liu J, Xiang H.	Appl Microbiol Biotechnol	10.1007/s00253-013-4969-8	2014
	Characterization of the minimal replicon of pHM300 and independent copy number control of major and minor chromosomes of Haloferax mediterranei.	Liu X, Miao D, Zhang F, Wu Z, Liu J, Xiang H.	FEMS Microbiol Lett	10.1111/1574-6968.12052	2013
Metabolism	Regulation of ammonium assimilation in Haloferax mediterranei: interaction between glutamine synthetase and two GlnK proteins.	Pedro-Roig L, Camacho M, Bonete MJ.	Biochim Biophys Acta	10.1016/j.bbapap.2012.10.006	2013
Metabolism	Improving polyhydroxyalkanoate production by knocking out the genes involved in exopolysaccharide biosynthesis in Haloferax mediterranei.	Zhao D, Cai L, Wu J, Li M, Liu H, Han J, Zhou J, Xiang H.	Appl Microbiol Biotechnol	10.1007/s00253-012-4415-3	2013
Phylogeny	[Archaeons--still unknown microorganisms].	Efenberger M, Brzezinska-Blaszczyk E, Wodz K.	Postepy Hig Med Dosw (Online)	10.5604/17322693.1131697	2014
	Engineering Haloferax mediterranei as an Efficient Platform for High Level Production of Lycopene.	Zuo ZQ, Xue Q, Zhou J, Zhao DH, Han J, Xiang H.	Front Microbiol	10.3389/fmicb.2018.02893	2018
Pathogenicity	Stoichiometric and kinetic analysis of extreme halophilic Archaea on various substrates in a corrosion resistant bioreactor.	Lorantfy B, Seyer B, Herwig C.	N Biotechnol	10.1016/j.nbt.2013.08.003	2014
	Life in the brine of Lunenburg, Germany: unveiling microorganisms associated with Zechstein salt deposits.	Runzheimer K, Schwab L, Engel D, Schaudinn C, Laue M, Rebrosova K, Beblo-Vranesevic K, Azizah M, Leuko S.	Front Microbiol	10.3389/fmicb.2025.1625916	2025
	Rapid detection of haloarchaeal carotenoids via liquid-liquid microextraction enabled direct TLC MALDI-MS.	Manikandan M, Hasan N, Wu HF.	Talanta	10.1016/j.talanta.2013.01.005	2013
	Vinasse: from a residue to a high added value biopolymer.	Trape DV, Lopez OV, Villar MA.	Bioresour Bioprocess	10.1186/s40643-021-00476-1	2021
Metabolism	Cyclodextrin glycosyltransferase: a key enzyme in the assimilation of starch by the halophilic archaeon Haloferax mediterranei.	Bautista V, Esclapez J, Perez-Pomares F, Martinez-Espinosa RM, Camacho M, Bonete MJ.	Extremophiles	10.1007/s00792-011-0414-z	2012
	A TrmBL2-like transcription factor mediates the growth phase-dependent expression of halolysin SptA in a concentration-dependent manner in Natrinema gari J7-2.	Yin J, Liu Y, He D, Li P, Qiao M, Luo H, Qu X, Mei S, Wu Y, Sun Y, Gan F, Tang B, Tang X-F.	Appl Environ Microbiol	10.1128/aem.00741-24	2024
Metabolism	Comprehensive Bioinformatics Analysis of the Biodiversity of Lsm Proteins in the Archaea Domain.	Paya G, Bautista V, Camacho M, Esclapez J, Bonete MJ.	Microorganisms	10.3390/microorganisms11051196	2023
	Comparative Analysis of rRNA Removal Methods for RNA-Seq Differential Expression in Halophilic Archaea.	Pastor MM, Sakrikar S, Rodriguez DN, Schmid AK.	Biomolecules	10.3390/biom12050682	2022
	Low species barriers in halophilic archaea and the formation of recombinant hybrids.	Naor A, Lapierre P, Mevarech M, Papke RT, Gophna U.	Curr Biol	10.1016/j.cub.2012.05.056	2012
	Conversion of Short and Medium Chain Fatty Acids into Novel Polyhydroxyalkanoates Copolymers by Aeromonas sp. AC_01.	Szacherska K, Moraczewski K, Czaplicki S, Oleskowicz-Popiel P, Mozejko-Ciesielska J.	Materials (Basel)	10.3390/ma15134482	2022
	Systematic Analysis of Lysine Acetylation Reveals Diverse Functions in Azorhizobium caulinodans Strain ORS571.	Liu Y, Liu X, Dong X, Yin Z, Xie Z, Luo Y.	Microbiol Spectr	10.1128/spectrum.03539-22	2023
	Identification, Antioxidant Capacity, and Matrix Metallopeptidase 9 (MMP-9) In Silico Inhibition of Haloarchaeal Carotenoids from Natronococcus sp. and Halorubrum tebenquichense.	Delgado-Garcia M, Gomez-Secundino O, Rodriguez JA, Mateos-Diaz JC, Muller-Santos M, Aguilar CN, Camacho-Ruiz RM.	Microorganisms	10.3390/microorganisms11092344	2023
	Development of pyrF-based gene knockout systems for genome-wide manipulation of the archaea Haloferax mediterranei and Haloarcula hispanica.	Liu H, Han J, Liu X, Zhou J, Xiang H.	J Genet Genomics	10.1016/j.jgg.2011.05.003	2011
Metabolism	Optimising PHBV biopolymer production in haloarchaea via CRISPRi-mediated redirection of carbon flux.	Lin L, Chen J, Mitra R, Gao Q, Cheng F, Xu T, Zuo Z, Xiang H, Han J.	Commun Biol	10.1038/s42003-021-02541-z	2021
	Biochemical Characterization of the Amylase Activity from the New Haloarchaeal Strain Haloarcula sp. HS Isolated in the Odiel Marshlands.	Gomez-Villegas P, Vigara J, Romero L, Gotor C, Raposo S, Goncalves B, Leon R.	Biology (Basel)	10.3390/biology10040337	2021
	Characterization of a new exopolysaccharide produced by Halorubrum sp. TBZ112 and evaluation of its anti-proliferative effect on gastric cancer cells.	Hamidi M, Mirzaei R, Delattre C, Khanaki K, Pierre G, Gardarin C, Petit E, Karimitabar F, Faezi S.	3 Biotech	10.1007/s13205-018-1515-5	2019
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Metabolism	Perchlorate and halophilic prokaryotes: implications for possible halophilic life on Mars.	Oren A, Elevi Bardavid R, Mana L.	Extremophiles	10.1007/s00792-013-0594-9	2014
Phylogeny	Mapping of active replication origins in vivo in thaum- and euryarchaeal replicons.	Pelve EA, Martens-Habbena W, Stahl DA, Bernander R.	Mol Microbiol	10.1111/mmi.12382	2013
Metabolism	In vitro proof of direct regulation of glutamine synthetase by GlnK proteins in the extreme halophilic archaeon Haloferax mediterranei.	Pedro-Roig L, Camacho M, Bonete MJ.	Biochem Soc Trans	10.1042/bst0390259	2011
Metabolism	Role of the denitrifying Haloarchaea in the treatment of nitrite-brines.	Najera-Fernandez C, Zafrilla B, Bonete MJ, Martinez-Espinosa RM.	Int Microbiol	10.2436/20.1501.01.164	2012
Transcriptome	Function of the RNA-targeting class 2 type VI CRISPR Cas system of Rhodobacter capsulatus.	Kretz J, Borner J, Friedrich T, McIntosh M, Procida-Kowalski T, Gerken F, Wilhelm J, Klug G.	Front Microbiol	10.3389/fmicb.2024.1384543	2024
Genetics	Isolation and characterization of a Halomonas species for non-axenic growth-associated production of bio-polyesters from sustainable feedstocks.	Woo S-G, Averesch NJH, Berliner AJ, Deutzmann JS, Pane VE, Chatterjee S, Criddle CS.	Appl Environ Microbiol	10.1128/aem.00603-24	2024
Enzymology	[Identification of the phaB genes and analysis of the PHBV precursor supplying pathway in Haloferax mediterranei].	Feng B, Cai S, Han J, Liu H, Zhou J, Xiang H.	Wei Sheng Wu Xue Bao		2010
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	Intermolecular Gene Conversion for the Equalization of Genome Copies in the Polyploid Haloarchaeon Haloferax volcanii: Identification of Important Proteins.	Ozer H, Wasser D, Sandner L, Soppa J.	Genes (Basel)	10.3390/genes15070861	2024
	Sustainable biorefining and bioprocessing of green seaweed (Ulva spp.) for the production of edible (ulvan) and non-edible (polyhydroxyalkanoate) biopolymeric films.	Manikandan NA, Lens PNL.	Microb Cell Fact	10.1186/s12934-023-02154-7	2023
	Antioxidant Capacity of Carotenoid Extracts from the Haloarchaeon Halorhabdus utahensis.	Serino I, Squillaci G, Errichiello S, Carbone V, Baraldi L, La Cara F, Morana A.	Antioxidants (Basel)	10.3390/antiox12101840	2023
Metabolism	Enoyl-CoA hydratase mediates polyhydroxyalkanoate mobilization in Haloferax mediterranei.	Liu G, Cai S, Hou J, Zhao D, Han J, Zhou J, Xiang H.	Sci Rep	10.1038/srep24015	2016
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Metabolism	Identification of several intracellular carbohydrate-degrading activities from the halophilic archaeon Haloferax mediterranei.	Perez-Pomares F, Diaz S, Bautista V, Pire C, Bravo G, Esclapez J, Zafrilla B, Bonete MJ.	Extremophiles	10.1007/s00792-009-0246-2	2009
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Metabolism	Production of Polyhydroxyalkanoates by Two Halophilic Archaeal Isolates from Chott El Jerid Using Inexpensive Carbon Sources.	Ben Abdallah M, Karray F, Sayadi S.	Biomolecules	10.3390/biom10010109	2020
	Marine-derived biopolymers as potential bioplastics, an eco-friendly alternative.	Tennakoon P, Chandika P, Yi M, Jung WK.	iScience	10.1016/j.isci.2023.106404	2023
	Carotenoids synthesis affects the salt tolerance mechanism of Rhodopseudomonas palustris.	Li M, Zhu T, Yang R, Wang Z, Liu M, Yang J.	Front Microbiol	10.3389/fmicb.2023.1292937	2023
	Characterization of newly isolated thermotolerant bacterium Cupriavidus sp. CB15 from composting and its ability to produce polyhydroxyalkanoate from glycerol.	Yootoum A, Jantanasakulwong K, Rachtanapun P, Moukamnerd C, Chaiyaso T, Pumas C, Tanadchangsaeng N, Watanabe M, Fukui T, Insomphun C.	Microb Cell Fact	10.1186/s12934-023-02059-5	2023
Metabolism	Synthesis and production of polyhydroxyalkanoates by halophiles: current potential and future prospects.	Quillaguaman J, Guzman H, Van-Thuoc D, Hatti-Kaul R.	Appl Microbiol Biotechnol	10.1007/s00253-009-2397-6	2010
	Small protein mediates inhibition of ammonium transport in Methanosarcina mazei-an ancient mechanism?	Habenicht T, Weidenbach K, Velazquez-Campoy A, Buey RM, Balsera M, Schmitz RA.	Microbiol Spectr	10.1128/spectrum.02811-23	2023
	Sustainable Polyhydroxyalkanoate Production from Food Waste via Bacillus mycoides ICRI89: Enhanced 3D Printing with Poly (Methyl Methacrylate) Blend.	Rofeal M, Abdelmalek F, Pietrasik J.	Polymers (Basel)	10.3390/polym15204173	2023
	Temperature and pH optima of extremely halophilic archaea: a mini-review.	Bowers KJ, Wiegel J.	Extremophiles	10.1007/s00792-010-0347-y	2011
	Pervasive acquisition of CRISPR memory driven by inter-species mating of archaea can limit gene transfer and influence speciation.	Turgeman-Grott I, Joseph S, Marton S, Eizenshtein K, Naor A, Soucy SM, Stachler AE, Shalev Y, Zarkor M, Reshef L, Altman-Price N, Marchfelder A, Gophna U.	Nat Microbiol	10.1038/s41564-018-0302-8	2019
Metabolism	NO3-/NO2- assimilation in halophilic archaea: physiological analysis, nasA and nasD expressions.	Martinez-Espinosa RM, Lledo B, Marhuenda-Egea FC, Diaz S, Bonete MJ.	Extremophiles	10.1007/s00792-009-0266-y	2009
Metabolism	Spectopotentiometric properties and salt-dependent thermotolerance of a [2Fe-2S] ferredoxin-involved nitrate assimilation in Haloferax mediterranei.	Martinez-Espinosa RM, Richardson DJ, Butt JN, Bonete MJ.	FEMS Microbiol Lett	10.1111/j.1574-6968.2007.00942.x	2007
Metabolism	Glutamine synthetase and GlnR regulate nitrogen metabolism in Paenibacillus polymyxa WLY78.	Zhao X, Song Y, Wang T, Hua C, Hu R, Shang Y, Shi H, Chen S.	Appl Environ Microbiol	10.1128/aem.00139-23	2023
	Genomic and metabolic analyses reveal antagonistic lanthipeptides in archaea.	Liang H, Song ZM, Zhong Z, Zhang D, Yang W, Zhou L, Older EA, Li J, Wang H, Zeng Z, Li YX.	Microbiome	10.1186/s40168-023-01521-1	2023
	Evaluation of ultrasound velocity measurements for estimating protease activities using casein as substrate	Born K, Manns A, Dzeyk K, Lutz-Wahl S, Gau D, Fischer L.	Biotechnol Lett		2010
	Genome enrichment of rare and unknown species from complicated microbiomes by nanopore selective sequencing.	Sun Y, Cheng Z, Li X, Yang Q, Zhao B, Wu Z, Xia Y.	Genome Res	10.1101/gr.277266.122	2023
Metabolism	Production of Polyhydroxyalkanoates (PHAs) by Vibrio alginolyticus Strains Isolated from Salt Fields.	Li HF, Wang MR, Tian LY, Li ZJ.	Molecules	10.3390/molecules26206283	2021
Pathogenicity	The Viral Susceptibility of the Haloferax Species.	Aguirre Sourrouille Z, Schwarzer S, Lequime S, Oksanen HM, Quax TEF.	Viruses	10.3390/v14061344	2022
Metabolism	Anaerobiosis inhibits gas vesicle formation in halophilic Archaea.	Hechler T, Pfeifer F.	Mol Microbiol	10.1111/j.1365-2958.2008.06517.x	2009
	Bioengineering of air-filled protein nanoparticles by genetic and chemical functionalization.	Karan R, Renn D, Nozue S, Zhao L, Habuchi S, Allers T, Rueping M.	J Nanobiotechnology	10.1186/s12951-023-01866-7	2023
	Production and Characterization of alpha-Amylase from an Extremely Halophilic Archaeon, Haloferax sp. HA10.	Bajpai B, Chaudhary M, Saxena J.	Food Technol Biotechnol	10.17113/ftb.53.01.15.3824	2015
	A fermentation process for the production of poly(3-hydroxybutyrate) using waste cooking oil or waste fish oil as inexpensive carbon substrate.	Loan TT, Trang DTQ, Huy PQ, Ninh PX, Van Thuoc D.	Biotechnol Rep (Amst)	10.1016/j.btre.2022.e00700	2022
Enzymology	Analysis of acidic surface of Haloferax mediterranei glucose dehydrogenase by site-directed mutagenesis.	Esclapez J, Pire C, Bautista V, Martinez-Espinosa RM, Ferrer J, Bonete MJ.	FEBS Lett	10.1016/j.febslet.2007.01.054	2007
	Influence of the Carbon and Nitrogen Sources on Diabolican Production by the Marine Vibrio diabolicus Strain CNCM I-1629.	Delbarre-Ladrat C, Sinquin C, Marchand L, Bonnetot S, Zykwinska A, Verrez-Bagnis V, Colliec-Jouault S.	Polymers (Basel)	10.3390/polym14101994	2022
	Evaluation of polyhydroxyalkanoate (PHA) synthesis by Pichia sp. TSLS24 yeast isolated in Vietnam.	Thu NTT, Hoang LH, Cuong PK, Viet-Linh N, Nga TTH, Kim DD, Leong YK, Nhi-Cong LT.	Sci Rep	10.1038/s41598-023-28220-z	2023
	The CRISPR-Cas System and Clinical Applications of CRISPR-Based Gene Editing in Hematology with a Focus on Inherited Germline Predisposition to Hematologic Malignancies.	Kansal R.	Genes (Basel)	10.3390/genes15070863	2024
	Regulation of gvp genes encoding gas vesicle proteins in halophilic Archaea.	Scheuch S, Marschaus L, Sartorius-Neef S, Pfeifer F.	Arch Microbiol	10.1007/s00203-008-0362-x	2008
Metabolism	The effect of ammonium on assimilatory nitrate reduction in the haloarchaeon Haloferax mediterranei.	Martinez-Espinosa RM, Lledo B, Marhuenda-Egea FC, Bonete MJ.	Extremophiles	10.1007/s00792-007-0095-9	2007
	Evaluation of ultrasound velocity measurements for estimating protease activities using casein as substrate.	Born K, Manns A, Dzeyk K, Lutz-Wahl S, Gau D, Fischer L.	Biotechnol Lett	10.1007/s10529-009-0135-x	2010
Enzymology	An octameric prokaryotic glutamine synthetase from the haloarchaeon Haloferax mediterranei.	Martinez-Espinosa RM, Esclapez J, Bautista V, Bonete MJ.	FEMS Microbiol Lett	10.1111/j.1574-6968.2006.00434.x	2006
	Advances in biomanufacturing and recent biological applications of the fundamental bacterial carotenoids: a comprehensive review.	Al-Monofy KB, Farghali MH, Al-Madboly LA, Kamer AMA, Abdelaziz AA.	Microb Cell Fact	10.1186/s12934-025-02847-1	2025
	Hypersaline organic wastewater treatment: Biotechnological advances and engineering challenges.	Zhang YQ, Han JL, Cheng HY, Wang HC, Liu TJ, Liang B, Wang AJ.	Environ Sci Ecotechnol	10.1016/j.ese.2025.100542	2025
Metabolism	Glucose inhibits the formation of gas vesicles in Haloferax volcanii transformants.	Hechler T, Frech M, Pfeifer F.	Environ Microbiol	10.1111/j.1462-2920.2007.01426.x	2008
Metabolism	A new D-2-hydroxyacid dehydrogenase with dual coenzyme-specificity from Haloferax mediterranei, sequence analysis and heterologous overexpression.	Domenech J, Ferrer J.	Biochim Biophys Acta	10.1016/j.bbagen.2006.08.024	2006
	Insights into the Lysine Acetylome of the Haloarchaeon Haloferax volcanii during Oxidative Stress by Quantitative SILAC-Based Proteomics.	Couto-Rodriguez RL, Koh J, Chen S, Maupin-Furlow JA.	Antioxidants (Basel)	10.3390/antiox12061203	2023
Metabolism	Respiratory nitrate and nitrite pathway in the denitrifier haloarchaeon Haloferax mediterranei.	Martinez-Espinosa RM, Richardson DJ, Butt JN, Bonete MJ.	Biochem Soc Trans	10.1042/bst0340115	2006
Metabolism	Production of polyhydroxyalkanoates from inexpensive extruded rice bran and starch by Haloferax mediterranei.	Huang TY, Duan KJ, Huang SY, Chen CW.	J Ind Microbiol Biotechnol	10.1007/s10295-006-0098-z	2006
	Complete atomic structure of a native archaeal cell surface.	von Kugelgen A, Alva V, Bharat TAM.	Cell Rep	10.1016/j.celrep.2021.110052	2021
Phylogeny	Assessment of 16S rRNA Gene-Based Phylogenetic Diversity of Archaeal Communities in Halite-Crystal Salts Processed from Natural Saharan Saline Systems of Southern Tunisia.	Najjari A, Stathopoulou P, Elmnasri K, Hasnaoui F, Zidi I, Sghaier H, Ouzari HI, Cherif A, Tsiamis G.	Biology (Basel)	10.3390/biology10050397	2021
Enzymology	Gene cloning, heterologous overexpression and optimized refolding of the NAD-glutamate dehydrogenase from Haloferax mediterranei.	Diaz S, Perez-Pomares F, Pire C, Ferrer J, Bonete MJ.	Extremophiles	10.1007/s00792-005-0478-8	2006
Metabolism	Preparation and characterization of poly(hydroxyalkanoate) from the fermentation of Haloferax mediterranei.	Don TM, Chen CW, Chan TH.	J Biomater Sci Polym Ed	10.1163/156856206778937208	2006
Metabolism	Potential of various archae- and eubacterial strains as industrial polyhydroxyalkanoate producers from whey.	Koller M, Hesse P, Bona R, Kutschera C, Atlic A, Braunegg G.	Macromol Biosci	10.1002/mabi.200600211	2007
	PHA Production from Cheese Whey and "Scotta": Comparison between a Consortium and a Pure Culture of Leuconostoc mesenteroides.	Bosco F, Cirrincione S, Carletto R, Marmo L, Chiesa F, Mazzoli R, Pessione E.	Microorganisms	10.3390/microorganisms9122426	2021
Metabolism	Assessment of formal and low structured kinetic modeling of polyhydroxyalkanoate synthesis from complex substrates.	Koller M, Horvat P, Hesse P, Bona R, Kutschera C, Atlic A, Braunegg G.	Bioprocess Biosyst Eng	10.1007/s00449-006-0084-x	2006
	The gut microbiome in social anxiety disorder: evidence of altered composition and function.	Butler MI, Bastiaanssen TFS, Long-Smith C, Morkl S, Berding K, Ritz NL, Strain C, Patangia D, Patel S, Stanton C, O'Mahony SM, Cryan JF, Clarke G, Dinan TG.	Transl Psychiatry	10.1038/s41398-023-02325-5	2023
Metabolism	Identification and transcriptional analysis of nitrate assimilation genes in the halophilic archaeon Haloferax mediterranei.	Lledo B, Marhuenda-Egea FC, Martinez-Espinosa RM, Bonete MJ.	Gene	10.1016/j.gene.2005.07.011	2005
	Discovery of a novel transcriptional regulator of sugar catabolism in archaea.	Johnsen U, Ortjohann M, Reinhardt A, Turner JM, Stratton C, Weber KR, Sanchez KM, Maupin-Furlow J, Davies C, Schonheit P.	Mol Microbiol	10.1111/mmi.15114	2023
Pathogenicity	The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration.	Cheng F, Wu A, Liu C, Cao X, Wang R, Shu X, Wang L, Zhang Y, Xiang H, Li M.	Nucleic Acids Res	10.1093/nar/gkac712	2022
Metabolism	GvpD-induced breakdown of the transcriptional activator GvpE of halophilic archaea requires a functional p-loop and an arginine-rich region of GvpD.	Scheuch S, Pfeifer F.	Microbiology (Reading)	10.1099/mic.0.2006/004499-0	2007
	Responses of haloarchaea to simulated microgravity.	Dornmayr-Pfaffenhuemer M, Legat A, Schwimbersky K, Fendrihan S, Stan-Lotter H.	Astrobiology	10.1089/ast.2010.0536	2011
Enzymology	A Second Gamma-Glutamylpolyamine Synthetase, GlnA2, Is Involved in Polyamine Catabolism in Streptomyces coelicolor.	Krysenko S, Okoniewski N, Nentwich M, Matthews A, Bauerle M, Zinser A, Busche T, Kulik A, Gursch S, Kemeny A, Bera A, Wohlleben W.	Int J Mol Sci	10.3390/ijms23073752	2022
	Uncovering novel polyhydroxyalkanoate biosynthesis genes and unique pathway in yeast hanseniaspora valbyensis for sustainable bioplastic production.	Abd-El-Haleem DAM, Elkatory MR, Abu-Elreesh GM.	Sci Rep	10.1038/s41598-024-77382-x	2024
Metabolism	Sucrose Metabolism in Haloarchaea: Reassessment Using Genomics, Proteomics, and Metagenomics.	Williams TJ, Allen MA, Liao Y, Raftery MJ, Cavicchioli R.	Appl Environ Microbiol	10.1128/aem.02935-18	2019
Genetics	Genomic analysis of heavy metal-resistant Halobacterium salinarum isolated from Sfax solar saltern sediments.	Baati H, Siala M, Azri C, Ammar E, Dunlap C, Trigui M.	Extremophiles	10.1007/s00792-022-01273-0	2022
	Optimization of bacterioruberin production from Halorubrum ruber and assessment of its antioxidant potential.	Hwang CY, Cho ES, Kim S, Kim K, Seo MJ.	Microb Cell Fact	10.1186/s12934-023-02274-0	2024
Enzymology	Crystallization and preliminary X-ray analysis of D-2-hydroxyacid dehydrogenase from Haloferax mediterranei.	Domenech J, Baker PJ, Sedelnikova SE, Rodgers HF, Rice DW, Ferrer J.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s174430910900863x	2009
Metabolism	Exploitation of inexpensive substrates for production of a novel SCL-LCL-PHA co-polymer by Pseudomonas aeruginosa MTCC 7925.	Singh AK, Mallick N.	J Ind Microbiol Biotechnol	10.1007/s10295-008-0503-x	2009
Metabolism	Bacterial biopolymer (polyhydroxyalkanoate) production from low-cost sustainable sources.	Aljuraifani AA, Berekaa MM, Ghazwani AA.	Microbiologyopen	10.1002/mbo3.755	2019
Metabolism	Respiratory nitrate reductase from haloarchaeon Haloferax mediterranei: biochemical and genetic analysis.	Lledo B, Martinez-Espinosa RM, Marhuenda-Egea FC, Bonete MJ.	Biochim Biophys Acta	10.1016/j.bbagen.2004.05.007	2004
	Recent Advances in the Study of Gas Vesicle Proteins and Application of Gas Vesicles in Biomedical Research.	Pfeifer F.	Life (Basel)	10.3390/life12091455	2022
	CRISPR-based point-of-care diagnostics incorporating Cas9, Cas12, and Cas13 enzymes advanced for SARS-CoV-2 detection.	Verma MK, Roychowdhury S, Sahu BD, Mishra A, Sethi KK.	J Biochem Mol Toxicol	10.1002/jbt.23113	2022
	Valorization of Waste from Argan Seeds for Polyhydroxybutyrate Production Using Bacterial Strains Isolated from Argan Soils.	Aragosa A, Specchia V, Frigione M.	Polymers (Basel)	10.3390/polym15081972	2023
	Genome-wide transcriptional response to silver stress in extremely halophilic archaeon Haloferax alexandrinus DSM 27206^T.	Buda DM, Szekeres E, Tudoran LB, Esclapez J, Banciu HL.	BMC Microbiol	10.1186/s12866-023-03133-z	2023
	An Eco-Friendly Conversion of Aquaculture Suspended Solid Wastes Into High-Quality Fish Food by Improving Poly-beta-Hydroxybutyrate Production.	Qiao G, Li X, Li J, Zhang M, Shen Y, Zhao Z, Zhang Y, Qi Z, Chen P, Sun Y, Cang P, Liu P, Wangkahart E, Wang Z.	Front Physiol	10.3389/fphys.2022.797625	2022
	Cloning and Molecular Characterization of an Alpha-Glucosidase (MalH) from the Halophilic Archaeon Haloquadratum walsbyi.	Cuebas-Irizarry MF, Irizarry-Caro RA, Lopez-Morales C, Badillo-Rivera KM, Rodriguez-Minguela CM, Montalvo-Rodriguez R.	Life (Basel)	10.3390/life7040046	2017
Phylogeny	Combination of Hypotonic Lysis and Application of Detergent for Isolation of Polyhydroxyalkanoates from Extremophiles.	Novackova I, Kourilova X, Mrazova K, Sedlacek P, Kalina M, Krzyzanek V, Koller M, Obruca S.	Polymers (Basel)	10.3390/polym14091761	2022
Genetics	Future Approaches for Treating Chronic Myeloid Leukemia: CRISPR Therapy.	Vuelta E, Garcia-Tunon I, Hernandez-Carabias P, Mendez L, Sanchez-Martin M.	Biology (Basel)	10.3390/biology10020118	2021
Metabolism	NMR studies of a ferredoxin from Haloferax mediterranei and its physiological role in nitrate assimilatory pathway.	Martinez-Espinosa RM, Marhuenda-Egea FC, Donaire A, Bonete MJ.	Biochim Biophys Acta	10.1016/s0304-4165(03)00157-0	2003
	Phylogenetic survey of the subtilase family and a data-mining-based search for new subtilisins from Bacillaceae.	Falkenberg F, Bott M, Bongaerts J, Siegert P.	Front Microbiol	10.3389/fmicb.2022.1017978	2022
	The First Insight into Polyhydroxyalkanoates Accumulation in Multi-Extremophilic Rubrobacter xylanophilus and Rubrobacter spartanus.	Kourilova X, Schwarzerova J, Pernicova I, Sedlar K, Mrazova K, Krzyzanek V, Nebesarova J, Obruca S.	Microorganisms	10.3390/microorganisms9050909	2021
Enzymology	Alpha-amylase activity from the halophilic archaeon Haloferax mediterranei.	Perez-Pomares F, Bautista V, Ferrer J, Pire C, Marhuenda-Egea FC, Bonete MJ.	Extremophiles	10.1007/s00792-003-0327-6	2003
	Differences in regulation mechanisms of glutamine synthetases from methanogenic archaea unveiled by structural investigations.	Muller MC, Lemaire ON, Kurth JM, Welte CU, Wagner T.	Commun Biol	10.1038/s42003-023-05726-w	2024
	Regulation of the expression of gas vesicle genes in Haloferax mediterranei: interaction of the two regulatory proteins GvpD and GvpE.	Zimmermann P, Pfeifer F.	Mol Microbiol	10.1046/j.1365-2958.2003.03593.x	2003
	Acetate Metabolism in Archaea: Characterization of an Acetate Transporter and of Enzymes Involved in Acetate Activation and Gluconeogenesis in Haloferax volcanii.	Kuprat T, Johnsen U, Ortjohann M, Schonheit P.	Front Microbiol	10.3389/fmicb.2020.604926	2020
	The Hypersaline Archaeal Histones HpyA and HstA Are DNA Binding Proteins That Defy Categorization According to Commonly Used Functional Criteria.	Sakrikar S, Hackley RK, Martinez-Pastor M, Darnell CL, Vreugdenhil A, Schmid AK.	mBio	10.1128/mbio.03449-22	2023
Metabolism	Haloarchaeal-type beta-ketothiolases involved in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in Haloferax mediterranei.	Hou J, Feng B, Han J, Liu H, Zhao D, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.01370-13	2013
Metabolism	Microbial gas vesicles as nanotechnology tools: exploiting intracellular organelles for translational utility in biotechnology, medicine and the environment.	Hill AM, Salmond GPC.	Microbiology (Reading)	10.1099/mic.0.000912	2020
Metabolism	In vivo analyses of constitutive and regulated promoters in halophilic archaea.	Gregor D, Pfeifer F.	Microbiology (Reading)	10.1099/mic.0.27541-0	2005
	Comparison of four phaC genes from Haloferax mediterranei and their function in different PHBV copolymer biosyntheses in Haloarcula hispanica.	Han J, Li M, Hou J, Wu L, Zhou J, Xiang H.	Saline Syst	10.1186/1746-1448-6-9	2010
Genetics	Developing Bioprospecting Strategies for Bioplastics Through the Large-Scale Mining of Microbial Genomes.	Vuong P, Lim DJ, Murphy DV, Wise MJ, Whiteley AS, Kaur P.	Front Microbiol	10.3389/fmicb.2021.697309	2021
Metabolism	Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.	Cai L, Cai S, Zhao D, Wu J, Wang L, Liu X, Li M, Hou J, Zhou J, Liu J, Han J, Xiang H.	Appl Environ Microbiol	10.1128/aem.03372-13	2014
Metabolism	In vivo and in vitro studies of RNA degrading activities in Archaea.	Evguenieva-Hackenberg E, Wagner S, Klug G.	Methods Enzymol	10.1016/s0076-6879(08)02219-2	2008
Metabolism	Rational engineering of Kluyveromyces marxianus to create a chassis for the production of aromatic products.	Rajkumar AS, Morrissey JP.	Microb Cell Fact	10.1186/s12934-020-01461-7	2020
Metabolism	Characterization of CRISPR RNA biogenesis and Cas6 cleavage-mediated inhibition of a provirus in the haloarchaeon Haloferax mediterranei.	Li M, Liu H, Han J, Liu J, Wang R, Zhao D, Zhou J, Xiang H.	J Bacteriol	10.1128/jb.01688-12	2013
	Metabolic Potential of Microbial Communities in the Hypersaline Sediments of the Bonneville Salt Flats.	McGonigle JM, Bernau JA, Bowen BB, Brazelton WJ.	mSystems	10.1128/msystems.00846-22	2022
Enzymology	DMSO Reductase Family: Phylogenetics and Applications of Extremophiles.	Miralles-Robledillo JM, Torregrosa-Crespo J, Martinez-Espinosa RM, Pire C.	Int J Mol Sci	10.3390/ijms20133349	2019
Metabolism	Assimilatory nitrate reductase from the haloarchaeon Haloferax mediterranei: purification and characterisation.	Martinez-Espinosa RM, Marhuenda-Egea FC, Bonete MJ.	FEMS Microbiol Lett	10.1016/s0378-1097(01)00431-1	2001
Enzymology	Crystallization and preliminary X-ray analysis of glucose dehydrogenase from Haloferax mediterranei.	Ferrer J, Fisher M, Burke J, Sedelnikova SE, Baker PJ, Gilmour DJ, Bonete MJ, Pire C, Esclapez J, Rice DW.	Acta Crystallogr D Biol Crystallogr	10.1107/s0907444901015189	2001
Genetics	Extremophilic Bacterium Halomonas desertis G11 as a Cell Factory for Poly-3-Hydroxybutyrate-co-3-Hydroxyvalerate Copolymer's Production.	Hammami K, Souissi Y, Souii A, Ouertani A, El-Hidri D, Jabberi M, Chouchane H, Mosbah A, Masmoudi AS, Cherif A, Neifar M.	Front Bioeng Biotechnol	10.3389/fbioe.2022.878843	2022
Enzymology	Valorization of agro-wastes for the biosynthesis and characterization of polyhydroxybutyrate by Bacillus sp. isolated from rice bran dumping yard.	Krishnan S, Chinnadurai GS, Ravishankar K, Raghavachari D, Perumal P.	3 Biotech	10.1007/s13205-021-02722-x	2021
Metabolism	Sea-Ice Bacteria Halomonas sp. Strain 363 and Paracoccus sp. Strain 392 Produce Multiple Types of Poly-3-Hydroxyalkaonoic Acid (PHA) Storage Polymers at Low Temperature.	Eronen-Rasimus E, Hultman J, Hai T, Pessi IS, Collins E, Wright S, Laine P, Viitamaki S, Lyra C, Thomas DN, Golyshin PN, Luhtanen AM, Kuosa H, Kaartokallio H.	Appl Environ Microbiol	10.1128/aem.00929-21	2021
Enzymology	Heterologous overexpression of glucose dehydrogenase from the halophilic archaeon Haloferax mediterranei, an enzyme of the medium chain dehydrogenase/reductase family.	Pire C, Esclapez J, Ferrer J, Bonete MJ.	FEMS Microbiol Lett	10.1111/j.1574-6968.2001.tb10719.x	2001
	Upcycling Biodegradable PVA/Starch Film to a Bacterial Biopigment and Biopolymer.	Pantelic B, Ponjavic M, Jankovic V, Aleksic I, Stevanovic S, Murray J, Fournet MB, Nikodinovic-Runic J.	Polymers (Basel)	10.3390/polym13213692	2021
	Functional Insights of Salinity Stress-Related Pathways in Metagenome-Resolved Methanothrix Genomes.	Gagliano MC, Sampara P, Plugge CM, Temmink H, Sudmalis D, Ziels RM.	Appl Environ Microbiol	10.1128/aem.02449-21	2022
	Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy.	Ahmadi SE, Soleymani M, Shahriyary F, Amirzargar MR, Ofoghi M, Fattahi MD, Safa M.	Cancer Gene Ther	10.1038/s41417-023-00597-z	2023
Biotechnology	Marine cosmetics and the blue bioeconomy: From sourcing to success stories.	Rotter A, Varamogianni-Mamatsi D, Zvonar Pobirk A, Gosenca Matjaz M, Cueto M, Diaz-Marrero AR, Jonsdottir R, Sveinsdottir K, Catala TS, Romano G, Aslanbay Guler B, Atak E, Berden Zrimec M, Bosch D, Deniz I, Gaudencio SP, Grigalionyte-Bembic E, Klun K, Zidar L, Coll Rius A, Baebler S, Lukic Bilela L, Rinkevich B, Mandalakis M.	iScience	10.1016/j.isci.2024.111339	2024
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Metabolism	Key Enzymes of the Semiphosphorylative Entner-Doudoroff Pathway in the Haloarchaeon Haloferax volcanii: Characterization of Glucose Dehydrogenase, Gluconate Dehydratase, and 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase.	Sutter JM, Tastensen JB, Johnsen U, Soppa J, Schonheit P.	J Bacteriol	10.1128/jb.00286-16	2016
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Enzymology	Alternative Translation Initiation of a Haloarchaeal Serine Protease Transcript Containing Two In-Frame Start Codons.	Tang W, Wu Y, Li M, Wang J, Mei S, Tang B, Tang XF.	J Bacteriol	10.1128/jb.00202-16	2016
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Metabolism	Complete biosynthetic pathway of the C50 carotenoid bacterioruberin from lycopene in the extremely halophilic archaeon Haloarcula japonica.	Yang Y, Yatsunami R, Ando A, Miyoko N, Fukui T, Takaichi S, Nakamura S.	J Bacteriol	10.1128/jb.02523-14	2015
Enzymology	Distribution and phylogenies of enzymes of the Embden-Meyerhof-Parnas pathway from archaea and hyperthermophilic bacteria support a gluconeogenic origin of metabolism.	Ronimus RS, Morgan HW.	Archaea	10.1155/2003/162593	2003
Metabolism	Anaerobic Growth of Haloarchaeon Haloferax volcanii by Denitrification Is Controlled by the Transcription Regulator NarO.	Hattori T, Shiba H, Ashiki K, Araki T, Nagashima YK, Yoshimatsu K, Fujiwara T.	J Bacteriol	10.1128/jb.00833-15	2016
Genetics	Genomic Insights Into the Archaea Inhabiting an Australian Radioactive Legacy Site.	Vazquez-Campos X, Kinsela AS, Bligh MW, Payne TE, Wilkins MR, Waite TD.	Front Microbiol	10.3389/fmicb.2021.732575	2021
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Genetics	Association between the dynamics of multiple replication origins and the evolution of multireplicon genome architecture in haloarchaea.	Wu Z, Yang H, Liu J, Wang L, Xiang H.	Genome Biol Evol	10.1093/gbe/evu219	2014
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Metabolism	Comparative Analysis of Archaeal Lipid-linked Oligosaccharides That Serve as Oligosaccharide Donors for Asn Glycosylation.	Taguchi Y, Fujinami D, Kohda D.	J Biol Chem	10.1074/jbc.m115.713156	2016
Metabolism	Shifts in coastal sediment oxygenation cause pronounced changes in microbial community composition and associated metabolism.	Broman E, Sjostedt J, Pinhassi J, Dopson M.	Microbiome	10.1186/s40168-017-0311-5	2017
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Metabolism	Microbial ecology of an Antarctic hypersaline lake: genomic assessment of ecophysiology among dominant haloarchaea.	Williams TJ, Allen MA, DeMaere MZ, Kyrpides NC, Tringe SG, Woyke T, Cavicchioli R.	ISME J	10.1038/ismej.2014.18	2014
Genetics	Comprehending the evolution of gene editing platforms for crop trait improvement.	Dhakate P, Sehgal D, Vaishnavi S, Chandra A, Singh A, Raina SN, Rajpal VR.	Front Genet	10.3389/fgene.2022.876987	2022
Metabolism	Isolation and biochemical characterization of a glucose dehydrogenase from a hay infusion metagenome.	Basner A, Antranikian G.	PLoS One	10.1371/journal.pone.0085844	2014
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Metabolism	Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase.	Pickl A, Johnsen U, Schonheit P.	J Bacteriol	10.1128/jb.00200-12	2012
Enzymology	Role of conserved glycine in zinc-dependent medium chain dehydrogenase/reductase superfamily.	Tiwari MK, Singh RK, Singh R, Jeya M, Zhao H, Lee JK.	J Biol Chem	10.1074/jbc.m111.335752	2012
Metabolism	Chitin accelerates activation of a novel haloarchaeal serine protease that deproteinizes chitin-containing biomass.	Zhang Y, Wang M, Du X, Tang W, Zhang L, Li M, Wang J, Tang B, Tang XF.	Appl Environ Microbiol	10.1128/aem.01196-14	2014
Metabolism	Comparative genomics study of polyhydroxyalkanoates (PHA) and ectoine relevant genes from Halomonas sp. TD01 revealed extensive horizontal gene transfer events and co-evolutionary relationships.	Cai L, Tan D, Aibaidula G, Dong XR, Chen JC, Tian WD, Chen GQ.	Microb Cell Fact	10.1186/1475-2859-10-88	2011
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Metabolism	Quinol-cytochrome c oxidoreductase and cytochrome c4 mediate electron transfer during selenate respiration in Thauera selenatis.	Lowe EC, Bydder S, Hartshorne RS, Tape HL, Dridge EJ, Debieux CM, Paszkiewicz K, Singleton I, Lewis RJ, Santini JM, Richardson DJ, Butler CS.	J Biol Chem	10.1074/jbc.m110.115873	2010
Metabolism	A conserved chloramphenicol binding site at the entrance to the ribosomal peptide exit tunnel.	Long KS, Porse BT.	Nucleic Acids Res	10.1093/nar/gkg945	2003
Metabolism	Molecular analysis of the role of two aromatic aminotransferases and a broad-specificity aspartate aminotransferase in the aromatic amino acid metabolism of Pyrococcus furiosus.	Ward DE, de Vos WM, van der Oost J.	Archaea	10.1155/2002/959031	2002
Genetics	Living with two extremes: conclusions from the genome sequence of Natronomonas pharaonis.	Falb M, Pfeiffer F, Palm P, Rodewald K, Hickmann V, Tittor J, Oesterhelt D.	Genome Res	10.1101/gr.3952905	2005
Metabolism	A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.	Haft DH, Selengut J, Mongodin EF, Nelson KE.	PLoS Comput Biol	10.1371/journal.pcbi.0010060	2005
Metabolism	Posttranslational protein modification in Archaea.	Eichler J, Adams MW, Adams MW.	Microbiol Mol Biol Rev	10.1128/mmbr.69.3.393-425.2005	2005
	Protein attributes contribute to halo-stability, bioinformatics approach.	Ebrahimie E, Ebrahimi M, Sarvestani NR, Ebrahimi M.	Saline Syst	10.1186/1746-1448-7-1	2011
Metabolism	Conformational changes induced in the Saccharomyces cerevisiae GTPase-associated rRNA by ribosomal stalk components and a translocation inhibitor.	Briones C, Ballesta JP.	Nucleic Acids Res	10.1093/nar/28.22.4497	2000
Enzymology	Novel xylose dehydrogenase in the halophilic archaeon Haloarcula marismortui.	Johnsen U, Schonheit P.	J Bacteriol	10.1128/jb.186.18.6198-6207.2004	2004
Metabolism	Metabolism of halophilic archaea.	Falb M, Muller K, Konigsmaier L, Oberwinkler T, Horn P, von Gronau S, Gonzalez O, Pfeiffer F, Bornberg-Bauer E, Oesterhelt D.	Extremophiles	10.1007/s00792-008-0138-x	2008
	Low-pass sequencing for microbial comparative genomics.	Goo YA, Roach J, Glusman G, Baliga NS, Deutsch K, Pan M, Kennedy S, DasSarma S, Ng WV, Hood L.	BMC Genomics	10.1186/1471-2164-5-3	2004
Metabolism	Amino acid biosynthesis in the halophilic archaeon Haloarcula hispanica.	Hochuli M, Patzelt H, Oesterhelt D, Wuthrich K, Szyperski T.	J Bacteriol	10.1128/jb.181.10.3226-3237.1999	1999
	Molecular Sensing with Host Systems for Hyperpolarized ¹²⁹Xe.	Jayapaul J, Schroder L.	Molecules	10.3390/molecules25204627	2020
Biotechnology	Haloarchaea have a high genomic diversity for the biosynthesis of carotenoids of biotechnological interest.	Serrano S, Mendo S, Caetano T	Res Microbiol	10.1016/j.resmic.2021.103919	2021
Stress	Influence of nutritive factors on C50 carotenoids production by Haloferax mediterranei ATCC 33500 with two-stage cultivation.	Fang CJ, Ku KL, Lee MH, Su NW	Bioresour Technol	10.1016/j.biortech.2010.03.044	2010
Phylogeny	Nucleotide sequence of the 235 rRNA from Haloferax mediterranei and phylogenetic analysis of halophilic archaea based on LSU rRNA.	Briones C, Amils R	Syst Appl Microbiol	10.1016/s0723-2020(00)80053-3	2000
Genetics	The structure of the exopolysaccharide produced by the halophilic Archaeon Haloferax mediterranei strain R4 (ATCC 33500).	Parolis H, Parolis LA, Boan IF, Rodriguez-Valera F, Widmalm G, Manca MC, Jansson PE, Sutherland IW	Carbohydr Res	10.1016/s0008-6215(96)90134-2	1996
	Recovery of bacterioruberin and proteins using aqueous solutions of surface-active compounds.	Vaz BMC, Kholany M, Pinto DCGA, Macario IPE, Veloso T, Caetano T, Pereira JL, Coutinho JAP, Ventura SPM	RSC Adv	10.1039/d2ra02581g	2022
Biotechnology	Exploitation of wasted bread as substrate for polyhydroxyalkanoates production through the use of Haloferax mediterranei and seawater.	Montemurro M, Salvatori G, Alfano S, Martinelli A, Verni M, Pontonio E, Villano M, Rizzello CG	Front Microbiol	10.3389/fmicb.2022.1000962	2022
	Assessment of Haloferax mediterranei Genome in Search of Copper-Molecular Machinery With Potential Applications for Bioremediation.	Llorca MG, Martinez-Espinosa RM	Front Microbiol	10.3389/fmicb.2022.895296	2022
Enzymology	Haloferax chudinovii sp. nov., a halophilic archaeon from Permian potassium salt deposits.	Saralov AI, Baslerov RV, Kuznetsov BB.	Extremophiles	10.1007/s00792-013-0534-8	2013
	Phenotypic and genomic characterization of Bathyarchaeum tardum gen. nov., sp. nov., a cultivated representative of the archaeal class Bathyarchaeia.	Khomyakova MA, Merkel AY, Mamiy DD, Klyukina AA, Slobodkin AI.	Front Microbiol	10.3389/fmicb.2023.1214631	2023
Phylogeny	Haloplanus natans gen. nov., sp. nov., an extremely halophilic, gas-vacuolate archaeon isolated from Dead Sea-Red Sea water mixtures in experimental outdoor ponds.	Bardavid RE, Mana L, Oren A.	Int J Syst Evol Microbiol	10.1099/ijs.0.64648-0	2007
Genetics	Genome sequence and description of Haloferax massiliense sp. nov., a new halophilic archaeon isolated from the human gut.	Khelaifia S, Caputo A, Andrieu C, Cadoret F, Armstrong N, Michelle C, Lagier JC, Djossou F, Fournier PE, Raoult D.	Extremophiles	10.1007/s00792-018-1011-1	2018
Genetics	Non-contiguous finished genome sequence and description of Halopiger goleamassiliensis sp. nov.	Ikram HI, Catherine R, Caroline M, Didier R, Hocine H, Christelle D.	Stand Genomic Sci	10.4056/sigs.4618288	2014

References

#496	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 1411
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Haloferax mediterranei (DSM 1411, ATCC 33500, CCM 3361)

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