Haloarcula hispanica (DSM 4426, ATCC 33960, NCMB 2187)

Name: Haloarcula hispanica (DSM 4426, ATCC 33960, NCMB 2187)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 5900

Type strain

Strain Designation Y-27, Y.27

Culture col. no. DSM 4426 ATCC 33960 NCMB 2187 Y-27 Y.27 6 more

NCBI tax ID(s) 634497 51589

Special Collections DSMZ JCM

History <- B.J. Tindall <- F. Rodriguez-Valera <- G. Juez, Y.27 IAM 13179 <-- F. Rodriguez-Valera Y27.

Links

Haloarcula hispanica Y-27 is an archaeon that was isolated from solar saltern.

genome sequence 16S sequence Archaea

Name and taxonomic classification

SI-ID 125934

ATCC 33960,DSM 4426,NCMB 2187,JCM 8911,CCM 3601,IAM 13179,NCIMB 2187,VKM B-1755,NBRC 102182,CGMCC 1.2049

@ref 20215

Last LPSN update 2026-02-09 11:19:05

Domain Archaea

Phylum Methanobacteriota

Class Halobacteria

Order Halobacteriales

Family Haloarculaceae

Genus Haloarcula

Species Haloarcula hispanica

Full scientific name Haloarcula hispanica Juez et al. 1986

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	97.1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
1665	HALOBACTERIA MEDIUM (DSMZ Medium 372)		Medium recipe at MediaDive	Name: HALOBACTERIA MEDIUM (DSMZ Medium 372) Composition: NaCl 200.0 g/l MgSO4 x 7 H2O 20.0 g/l Agar 20.0 g/l Yeast extract 5.0 g/l Casamino acids 5.0 g/l Na3-citrate 3.0 g/l KCl 2.0 g/l Na glutamate 1.0 g/l FeCl2 x 4 H2O 0.036 g/l MnCl2 x 4 H2O 0.00036 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
1665	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	aerobe	90.6

Spore formation

@ref	Spore formation	Confidence
125439		96.8

Observation

67770

Observationquinones: MK-8

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2
#Condition	#Saline

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
1665	solar saltern	Alicante	Spain	ESP	Europe
67770	Solar saltern near Alicante		Spain	ESP	Europe

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
1665	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM22390v1 assembly for Haloarcula hispanica ATCC 33960 CGMCC 1.2049	complete	GCA_000223905	634497.12	2511231068	634497	98.89
124043	ASM3954521v1 assembly for Haloarcula hispanica NBRC 102182	contig	GCA_039545215			51589	76.28

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Haloarcula hispanica gene for 16S rRNA, partial sequence, rrnA operon	AB090167	1472	634497
20218	Haloarcula hispanica gene for 16S rRNA, partial sequence, rrnB operon	AB090168	1472	634497
20218	Haloarcula hispanica strain ATCC 33960 16S ribosomal RNA gene, complete sequence	U68541	1469	634497
20218	Haloarcula hispanica strain CGMCC1.2049 16S ribosomal RNA (rrnA) gene, complete sequence	EF645682	1472	51589
20218	Haloarcula hispanica strain CGMCC1.2049 16S ribosomal RNA (rrnB) gene, complete sequence	EF645683	1472	51589
20218	Haloarcula hispanica gene for 16S ribosomal RNA, partial sequence, strain: JCM 8911	AB355985	1472	634497
20218	Haloarcula hispanica gene for 16S rRNA, complete sequence, strain: JCM 8911	AB663352	1472	634497
124043	Haloarcula hispanica gene for 16S ribosomal RNA, partial sequence, strain: JCM8911, note: rrsA.	LC085245	1405	51589
124043	Haloarcula hispanica gene for 16S ribosomal RNA, partial sequence, strain: JCM8911, note: rrsB.	LC085246	1405	51589
124043	Haloarcula hispanica gene for 16S ribosomal RNA, partial sequence, strain: JCM8911, note: rrsC.	LC085247	1405	51589
124043	Haloarcula hispanica ATCC 33960 partial 16S rRNA gene, strain JC583, isolate V-224	LT986728	640	634497
124043	Haloarcula hispanica ATCC 33960 partial 16S rRNA gene, strain JC585, isolate V-226	LT986730	682	634497

GC content

@ref	GC-content (mol%)	Method
1665	62.7
67770	61.8	thermal denaturation, midpoint method (Tm)
67770	62.7	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Haloarcula hispanica ATCC 33960 CGMCC 1.2049
NCBI: GCA_000223905

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	96.80	no
125439	motility	BacteriaNetⓘ	yes	67.40	no
125439	gram_stain	BacteriaNetⓘ	negative	97.10	no
125439	oxygen_tolerance	BacteriaNetⓘ	aerobe	90.60	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Haloarcula hispanica ATCC 33960 CGMCC 1.2049
NCBI: GCA_000223905.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	77.50	no
125438	anaerobic	anaerobicⓘ	no	83.13	no
125438	aerobic	aerobicⓘ	yes	78.59	no
125438	spore-forming	spore-formingⓘ	no	82.13	no
125438	thermophilic	thermophileⓘ	no	80.95	yes
125438	flagellated	motile2+ⓘ	no	83.00	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Tat-fimbriae ("tafi"): An unusual type of haloarchaeal surface structure depending on the twin-arginine translocation pathway.	Galeva AV, Zhao D, Syutkin AS, Topilina MY, Shchyogolev SY, Pavlova EY, Selivanova OM, Kireev II, Surin AK, Burygin GL, Liu J, Xiang H, Pyatibratov MG.	iScience	10.1016/j.isci.2025.111793	2025
	Construction of Expression Shuttle Vectors for the Haloarchaeon Natrinema sp. J7 Based on Its Chromosomal Origins of Replication.	Wang Y, Chen B, Sima L, Cao M, Chen X.	Archaea	10.1155/2017/4237079	2017
Metabolism	Isolation and Molecular Identification of Auxotrophic Mutants to Develop a Genetic Manipulation System for the Haloarchaeon Natrinema sp. J7-2.	Lv J, Wang S, Wang Y, Huang Y, Chen X.	Archaea	10.1155/2015/483194	2015
	Identification, Characterization, and Application of the Replicon Region of the Halophilic Temperate Sphaerolipovirus SNJ1.	Wang Y, Sima L, Lv J, Huang S, Liu Y, Wang J, Krupovic M, Chen X.	J Bacteriol	10.1128/jb.00131-16	2016
Phylogeny	Characterization by polyphasic approach of some indigenous halophilic archaea of Djelfa's rock salt "Hadjr el Meelh", Algeria.	Beddal A, Boutaiba S, Laassami A, Hamaidi F, Enache M.	Iran J Microbiol	10.18502/ijm.v14i4.10240	2022
	Halolysin R4 of Haloferax mediterranei confers its host antagonistic and defensive activities.	Chen S, Sun S, Wang R, Feng H, Xiang H.	Appl Environ Microbiol	10.1128/aem.02889-20	2021
Genetics	Catalytically active prokaryotic Argonautes employ phospholipase D family proteins to strengthen immunity against different genetic invaders.	Cheng F, Wu A, Li Z, Xu J, Cao X, Yu H, Liu Z, Wang R, Han W, Xiang H, Li M.	mLife	10.1002/mlf2.12138	2024
	Unraveling Anaerobic Metabolisms in a Hypersaline Sediment.	Solchaga JI, Busalmen JP, Nercessian D.	Front Microbiol	10.3389/fmicb.2022.811432	2022
	Reprogramming the endogenous type I CRISPR-Cas system for simultaneous gene regulation and editing in Haloarcula hispanica.	Du K, Gong L, Li M, Yu H, Xiang H.	mLife	10.1002/mlf2.12010	2022
	Halocin H4 is activated through cleavage by halolysin HlyR4.	Chen S, Dai Y, Ke J, Luo Y, Wang C, Hao Y, Zhang A, Han J, Xiang H.	Appl Environ Microbiol	10.1128/aem.02284-23	2024
Enzymology	Discovery of bacteriorhodopsins in Haloarchaeal species isolated from Indian solar salterns: deciphering the role of the N-terminal residues in protein folding and functional expression.	Verma DK, Baral I, Kumar A, Prasad SE, Thakur KG.	Microb Biotechnol	10.1111/1751-7915.13359	2019
Metabolism	Malate Synthase and beta-Methylmalyl Coenzyme A Lyase Reactions in the Methylaspartate Cycle in Haloarcula hispanica.	Borjian F, Han J, Hou J, Xiang H, Zarzycki J, Berg IA.	J Bacteriol	10.1128/jb.00657-16	2017
Phylogeny	Diversity of the Tryptophanase Gene and Its Evolutionary Implications in Living Organisms.	Boya BR, Kumar P, Lee JH, Lee J.	Microorganisms	10.3390/microorganisms9102156	2021
Genetics	Complete genome sequence of Haloarcula hispanica, a Model Haloarchaeon for studying genetics, metabolism, and virus-host interaction.	Liu H, Wu Z, Li M, Zhang F, Zheng H, Han J, Liu J, Zhou J, Wang S, Xiang H.	J Bacteriol	10.1128/jb.05953-11	2011
	The Unexplored Diversity of Pleolipoviruses: The Surprising Case of Two Viruses with Identical Major Structural Modules.	Atanasova NS, Heinio CH, Demina TA, Bamford DH, Oksanen HM.	Genes (Basel)	10.3390/genes9030131	2018
	Primed adaptation tolerates extensive structural and size variations of the CRISPR RNA guide in Haloarcula hispanica.	Gong L, Li M, Cheng F, Zhao D, Chen Y, Xiang H.	Nucleic Acids Res	10.1093/nar/gkz244	2019
Genetics	Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes.	Luo H, Zhang CT, Gao F.	Front Microbiol	10.3389/fmicb.2014.00482	2014
Genetics	Association between the dynamics of multiple replication origins and the evolution of multireplicon genome architecture in haloarchaea.	Wu Z, Yang H, Liu J, Wang L, Xiang H.	Genome Biol Evol	10.1093/gbe/evu219	2014
Phylogeny	Archaeal Haloarcula californiae Icosahedral Virus 1 Highlights Conserved Elements in Icosahedral Membrane-Containing DNA Viruses from Extreme Environments.	Demina TA, Pietila MK, Svirskaite J, Ravantti JJ, Atanasova NS, Bamford DH, Oksanen HM.	mBio	10.1128/mbio.00699-16	2016
	Structural basis for assembly of vertical single beta-barrel viruses.	Santos-Perez I, Charro D, Gil-Carton D, Azkargorta M, Elortza F, Bamford DH, Oksanen HM, Abrescia NGA.	Nat Commun	10.1038/s41467-019-08927-2	2019
	Characterizing the DNA Methyltransferases of Haloferax volcanii via Bioinformatics, Gene Deletion, and SMRT Sequencing.	Ouellette M, Gogarten JP, Lajoie J, Makkay AM, Papke RT.	Genes (Basel)	10.3390/genes9030129	2018
	Adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process.	Li M, Wang R, Zhao D, Xiang H.	Nucleic Acids Res	10.1093/nar/gkt1154	2014
Pathogenicity	The toxin-antitoxin RNA guards of CRISPR-Cas evolved high specificity through repeat degeneration.	Cheng F, Wu A, Liu C, Cao X, Wang R, Shu X, Wang L, Zhang Y, Xiang H, Li M.	Nucleic Acids Res	10.1093/nar/gkac712	2022
Stress	HtrAs are essential for the survival of the haloarchaeon Natrinema gari J7-2 in response to heat, high salinity, and toxic substances.	Luo H, Qu X, Deng X, He L, Wu Y, Liu Y, He D, Yin J, Wang B, Gan F, Tang B, Tang X-F.	Appl Environ Microbiol	10.1128/aem.02048-23	2024
	DNA motifs determining the accuracy of repeat duplication during CRISPR adaptation in Haloarcula hispanica.	Wang R, Li M, Gong L, Hu S, Xiang H.	Nucleic Acids Res	10.1093/nar/gkw260	2016
	The spacer size of I-B CRISPR is modulated by the terminal sequence of the protospacer.	Li M, Gong L, Zhao D, Zhou J, Xiang H.	Nucleic Acids Res	10.1093/nar/gkx229	2017
	Phylogeny and Taxonomy of Archaea: A Comparison of the Whole-Genome-Based CVTree Approach with 16S rRNA Sequence Analysis.	Zuo G, Xu Z, Hao B.	Life (Basel)	10.3390/life5010949	2015
Metabolism	Molecular characterization of the phaECHm genes, required for biosynthesis of poly(3-hydroxybutyrate) in the extremely halophilic archaeon Haloarcula marismortui.	Han J, Lu Q, Zhou L, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.00953-07	2007
Metabolism	Divergent degeneration of creA antitoxin genes from minimal CRISPRs and the convergent strategy of tRNA-sequestering CreT toxins.	Cheng F, Wang R, Yu H, Liu C, Yang J, Xiang H, Li M.	Nucleic Acids Res	10.1093/nar/gkab821	2021
	Virion architecture unifies globally distributed pleolipoviruses infecting halophilic archaea.	Pietila MK, Atanasova NS, Manole V, Liljeroos L, Butcher SJ, Oksanen HM, Bamford DH.	J Virol	10.1128/jvi.06915-11	2012
	Assembly of complex viruses exemplified by a halophilic euryarchaeal virus.	De Colibus L, Roine E, Walter TS, Ilca SL, Wang X, Wang N, Roseman AM, Bamford D, Huiskonen JT, Stuart DI.	Nat Commun	10.1038/s41467-019-09451-z	2019
Genetics	Molecular characterization of the minimal replicon and the unidirectional theta replication of pSCM201 in extremely halophilic archaea.	Sun C, Zhou M, Li Y, Xiang H.	J Bacteriol	10.1128/jb.00988-06	2006
Enzymology	Heterologous and Homologous Expression of Proteins from Haloarchaea: Denitrification as Case of Study.	Martinez-Espinosa RM.	Int J Mol Sci	10.3390/ijms21010082	2019
	Closely related archaeal Haloarcula hispanica icosahedral viruses HHIV-2 and SH1 have nonhomologous genes encoding host recognition functions.	Jaakkola ST, Penttinen RK, Vilen ST, Jalasvuori M, Ronnholm G, Bamford JK, Bamford DH, Oksanen HM.	J Virol	10.1128/jvi.06666-11	2012
Metabolism	The methylaspartate cycle in haloarchaea and its possible role in carbon metabolism.	Borjian F, Han J, Hou J, Xiang H, Berg IA.	ISME J	10.1038/ismej.2015.132	2016
Metabolism	Identification of the polyhydroxyalkanoate (PHA)-specific acetoacetyl coenzyme A reductase among multiple FabG paralogs in Haloarcula hispanica and reconstruction of the PHA biosynthetic pathway in Haloferax volcanii.	Han J, Lu Q, Zhou L, Liu H, Xiang H.	Appl Environ Microbiol	10.1128/aem.00938-09	2009
	Differential Gene Expression in Response to Salinity and Temperature in a Haloarcula Strain from Great Salt Lake, Utah.	Almeida-Dalmet S, Litchfield CD, Gillevet P, Baxter BK.	Genes (Basel)	10.3390/genes9010052	2018
Phylogeny	PH1: an archaeovirus of Haloarcula hispanica related to SH1 and HHIV-2.	Porter K, Tang SL, Chen CP, Chiang PW, Hong MJ, Dyall-Smith M.	Archaea	10.1155/2013/456318	2013
	Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.	Corral P, Amoozegar MA, Ventosa A.	Mar Drugs	10.3390/md18010033	2019
Phylogeny	A Real-Time PCR Method to Detect the Population Level of Halovirus SNJ1.	Mei Y, He C, Deng W, Ba D, Yang M, Zhang J, Zhang S, Shen P, Chen X.	PLoS One	10.1371/journal.pone.0155642	2016
Metabolism	Anaerobic Growth of Haloarchaeon Haloferax volcanii by Denitrification Is Controlled by the Transcription Regulator NarO.	Hattori T, Shiba H, Ashiki K, Araki T, Nagashima YK, Yoshimatsu K, Fujiwara T.	J Bacteriol	10.1128/jb.00833-15	2016
	Transformation of members of the genus Haloarcula with shuttle vectors based on Halobacterium halobium and Haloferax volcanii plasmid replicons.	Cline SW, Doolittle WF.	J Bacteriol	10.1128/jb.174.3.1076-1080.1992	1992
Genetics	Related haloarchaeal pleomorphic viruses contain different genome types.	Sencilo A, Paulin L, Kellner S, Helm M, Roine E.	Nucleic Acids Res	10.1093/nar/gks215	2012
Metabolism	Dihydroxyacetone metabolism in Haloferax volcanii.	Ouellette M, Makkay AM, Papke RT.	Front Microbiol	10.3389/fmicb.2013.00376	2013
Enzymology	His1, an archaeal virus of the Fuselloviridae family that infects Haloarcula hispanica.	Bath C, Dyall-Smith ML.	J Virol	10.1128/jvi.72.11.9392-9395.1998	1998
	Lemon-shaped halo archaeal virus His1 with uniform tail but variable capsid structure.	Hong C, Pietila MK, Fu CJ, Schmid MF, Bamford DH, Chiu W.	Proc Natl Acad Sci U S A	10.1073/pnas.1425008112	2015
	Structures of Astaxanthin and Their Consequences for Therapeutic Application.	Brotosudarmo THP, Limantara L, Setiyono E, Heriyanto.	Int J Food Sci	10.1155/2020/2156582	2020
	Archaeal viruses multiply: temporal screening in a solar saltern.	Atanasova NS, Demina TA, Buivydas A, Bamford DH, Oksanen HM.	Viruses	10.3390/v7041902	2015
	Heavily Armed Ancestors: CRISPR Immunity and Applications in Archaea with a Comparative Analysis of CRISPR Types in Sulfolobales.	Zink IA, Wimmer E, Schleper C.	Biomolecules	10.3390/biom10111523	2020
	Constituents of SH1, a novel lipid-containing virus infecting the halophilic euryarchaeon Haloarcula hispanica.	Bamford DH, Ravantti JJ, Ronnholm G, Laurinavicius S, Kukkaro P, Dyall-Smith M, Somerharju P, Kalkkinen N, Bamford JK.	J Virol	10.1128/jvi.79.14.9097-9107.2005	2005
Metabolism	Genetic and biochemical characterization of the poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthase in Haloferax mediterranei.	Lu Q, Han J, Zhou L, Zhou J, Xiang H.	J Bacteriol	10.1128/jb.00134-08	2008
Metabolism	Precise determination, cross-recognition, and functional analysis of the double-strand origins of the rolling-circle replication plasmids in haloarchaea.	Zhou L, Zhou M, Sun C, Han J, Lu Q, Zhou J, Xiang H.	J Bacteriol	10.1128/jb.00596-08	2008
	Identification of polyhydroxyalkanoates in Halococcus and other haloarchaeal species.	Legat A, Gruber C, Zangger K, Wanner G, Stan-Lotter H.	Appl Microbiol Biotechnol	10.1007/s00253-010-2611-6	2010
Metabolism	Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNA(Leu) in the archaeal mode.	Fang ZP, Wang M, Ruan ZR, Tan M, Liu RJ, Zhou M, Zhou XL, Wang ED.	Nucleic Acids Res	10.1093/nar/gku108	2014
Phylogeny	Intragenomic heterogeneity of 16S rRNA genes causes overestimation of prokaryotic diversity.	Sun DL, Jiang X, Wu QL, Zhou NY.	Appl Environ Microbiol	10.1128/aem.01282-13	2013
Transcriptome	Population and genomic analysis of the genus Halorubrum.	Fullmer MS, Soucy SM, Swithers KS, Makkay AM, Wheeler R, Ventosa A, Gogarten JP, Papke RT.	Front Microbiol	10.3389/fmicb.2014.00140	2014
	Properties of Halococcus salifodinae, an Isolate from Permian Rock Salt Deposits, Compared with Halococci from Surface Waters.	Legat A, Denner EB, Dornmayr-Pfaffenhuemer M, Pfeiffer P, Knopf B, Claus H, Gruber C, Konig H, Wanner G, Stan-Lotter H.	Life (Basel)	10.3390/life3010244	2013
Genetics	Gene-Family Extension Measures and Correlations.	Carmi G, Bolshoy A.	Life (Basel)	10.3390/life6030030	2016
Enzymology	Exopolysaccharides from Marine and Marine Extremophilic Bacteria: Structures, Properties, Ecological Roles and Applications.	Casillo A, Lanzetta R, Parrilli M, Corsaro MM.	Mar Drugs	10.3390/md16020069	2018
Metabolism	Halophilic archaea and their potential to generate renewable fuels and chemicals.	Kasirajan L, Maupin-Furlow JA.	Biotechnol Bioeng	10.1002/bit.27639	2021
Metabolism	Sulfolobus Spindle-Shaped Virus 1 Contains Glycosylated Capsid Proteins, a Cellular Chromatin Protein, and Host-Derived Lipids.	Quemin ER, Pietila MK, Oksanen HM, Forterre P, Rijpstra WI, Schouten S, Bamford DH, Prangishvili D, Krupovic M.	J Virol	10.1128/jvi.02270-15	2015
	Aerobic Denitrification and Heterotrophic Sulfur Oxidation in the Genus Halomonas Revealed by Six Novel Species Characterizations and Genome-Based Analysis.	Wang L, Shao Z.	Front Microbiol	10.3389/fmicb.2021.652766	2021
Phylogeny	Diverse antimicrobial interactions of halophilic archaea and bacteria extend over geographical distances and cross the domain barrier.	Atanasova NS, Pietila MK, Oksanen HM.	Microbiologyopen	10.1002/mbo3.115	2013
	Astaxanthin: Past, Present, and Future.	Nishida Y, Berg PC, Shakersain B, Hecht K, Takikawa A, Tao R, Kakuta Y, Uragami C, Hashimoto H, Misawa N, Maoka T.	Mar Drugs	10.3390/md21100514	2023
Phylogeny	Temperature-dependent expression of different guanine-plus-cytosine content 16S rRNA genes in Haloarcula strains of the class Halobacteria.	Sato Y, Kimura H.	Antonie Van Leeuwenhoek	10.1007/s10482-018-1144-3	2019
	Sugar alcohol degradation in Archaea: uptake and degradation of mannitol and sorbitol in Haloarcula hispanica.	Ortjohann M, Schonheit P.	Extremophiles	10.1007/s00792-024-01365-z	2024
	Draft genomes of halophilic Archaea strains isolated from brines of the Carpathian Foreland, Poland.	Lach J, Strapagiel D, Matera-Witkiewicz A, Staczek P.	J Genomics	10.7150/jgen.82493	2023
Genetics	Carotenoid pigment of Halophilic archaeon Haloarcula sp. A15 induces apoptosis of breast cancer cells.	Shahbazi S, Zargar M, Zolfaghari MR, Amoozegar MA.	Cell Biochem Funct	10.1002/cbf.3786	2023
	Life in the brine of Lunenburg, Germany: unveiling microorganisms associated with Zechstein salt deposits.	Runzheimer K, Schwab L, Engel D, Schaudinn C, Laue M, Rebrosova K, Beblo-Vranesevic K, Azizah M, Leuko S.	Front Microbiol	10.3389/fmicb.2025.1625916	2025
	AepG is a glucuronosyltransferase involved in acidic exopolysaccharide synthesis and contributes to environmental adaptation of Haloarcula hispanica.	Pei C, Lu H, Ma J, Eichler J, Guan Z, Gao L, Liu L, Zhou H, Yang J, Jin C.	J Biol Chem	10.1016/j.jbc.2023.102911	2023
Metabolism	Agl22 and Agl23 are involved in the synthesis and utilization of the lipid-linked intermediates in the glycosylation pathways of the halophilic archaeaon Haloarcula hispanica.	Lu H, Pei C, Zhou H, Lu Y, He Y, Li Y, Han J, Xiang H, Eichler J, Jin C.	Mol Microbiol	10.1111/mmi.14577	2020
	Genetic identification of acetyl-CoA synthetases involved in acetate activation in Haloferax mediterranei.	Mitra R, Xu Y, Lin L, Guo J, Xu T, Zhou M, Guo F, Li H, Xiang H, Han J.	Appl Environ Microbiol	10.1128/aem.01843-24	2025
	Bacterioruberin: Biosynthesis, Antioxidant Activity, and Therapeutic Applications in Cancer and Immune Pathologies.	Giani M, Pire C, Martinez-Espinosa RM.	Mar Drugs	10.3390/md22040167	2024
	Rft1 catalyzes lipid-linked oligosaccharide translocation across the ER membrane.	Chen S, Pei CX, Xu S, Li H, Liu YS, Wang Y, Jin C, Dean N, Gao XD.	Nat Commun	10.1038/s41467-024-48999-3	2024
Enzymology	CTP synthase forms cytoophidia in archaea.	Zhou S, Xiang H, Liu JL.	J Genet Genomics	10.1016/j.jgg.2020.03.004	2020
	A new GH13 subfamily represented by the alpha-amylase from the halophilic archaeon Haloarcula hispanica.	Janecek S, Zamocka B.	Extremophiles	10.1007/s00792-019-01147-y	2020
	A conserved transcription factor controls gluconeogenesis via distinct targets in hypersaline-adapted archaea with diverse metabolic capabilities.	Hackley RK, Vreugdenhil-Hayslette A, Darnell CL, Schmid AK.	PLoS Genet	10.1371/journal.pgen.1011115	2024
Metabolism	Production of Polyhydroxyalkanoates in Unsterilized Hyper-Saline Medium by Halophiles Using Waste Silkworm Excrement as Carbon Source.	Cai S, Wu Y, Li Y, Yang S, Liu Z, Ma Y, Lv J, Shao Y, Jia H, Zhao Y, Cai L.	Molecules	10.3390/molecules26237122	2021
	Toxicity Assessment and Bioremediation of Deep Eutectic Solvents by Haloferax mediterranei: A Step toward Sustainable Circular Chemistry.	Martinez G, Guillena G, Martinez-Espinosa RM.	ChemSusChem	10.1002/cssc.202500825	2025
	Growth Phase Dependent Cell Shape of Haloarcula.	Schwarzer S, Rodriguez-Franco M, Oksanen HM, Quax TEF.	Microorganisms	10.3390/microorganisms9020231	2021
Genetics	Harnessing the native type I-B CRISPR-Cas for genome editing in a polyploid archaeon.	Cheng F, Gong L, Zhao D, Yang H, Zhou J, Li M, Xiang H.	J Genet Genomics	10.1016/j.jgg.2017.09.010	2017
Genetics	Production, characterization, and genomic insights of a human lectin-binding exopolysaccharide from Haloarcula japonica strain SST1.	Ghevondyan D, Hakobyan A, Margaryan A, Finore I, Cattaneo A, Chiodo F, Birkeland NK, Poli A, Panosyan H.	Sci Rep	10.1038/s41598-025-18462-4	2025
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Pathogenicity	The infection cycle of the haloarchaeal virus HFTV1 is tightly regulated and strongly inhibits motility of its host.	Schwarzer S, Backer LE, Nijland JG, Hayani Aji I, de Jong A, Moraru C, Steglich C, Quax TEF.	mSystems	10.1128/msystems.00704-25	2025
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Metabolism	d-Ribose Catabolism in Archaea: Discovery of a Novel Oxidative Pathway in Haloarcula Species.	Johnsen U, Sutter JM, Reinhardt A, Pickl A, Wang R, Xiang H, Schonheit P.	J Bacteriol	10.1128/jb.00608-19	2020
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Biotechnology	Comparative genomics of the highly halophilic Haloferacaceae.	Griffiths DB, Tiwari RP, Murphy DV, Scott C.	Sci Rep	10.1038/s41598-024-78438-8	2024
Metabolism	Identification of the S-layer glycoproteins and their covalently linked glycans in the halophilic archaeon Haloarcula hispanica.	Lu H, Lu Y, Ren J, Wang Z, Wang Q, Luo Y, Han J, Xiang H, Du Y, Jin C.	Glycobiology	10.1093/glycob/cwv050	2015
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Genetics	Scarless gene disruption enabled by a dual-plasmid knockout platform in a clinical infant-derived Bifidobacterium breve strain.	Gao Z, Feng L.	Front Microbiol	10.3389/fmicb.2025.1653505	2025
Metabolism	Halorubrum pleomorphic virus-6 Membrane Fusion Is Triggered by an S-Layer Component of Its Haloarchaeal Host.	Bignon EA, Chou KR, Roine E, Tischler ND.	Viruses	10.3390/v14020254	2022
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Metabolism	Temperature and pH dependence of DNA ejection from archaeal lemon-shaped virus His1.	Hanhijarvi KJ, Ziedaite G, Haeggstrom E, Bamford DH.	Eur Biophys J	10.1007/s00249-016-1112-7	2016
Genetics	Hi-TARGET: a fast, efficient and versatile CRISPR type I-B genome editing tool for the thermophilic acetogen Thermoanaerobacter kivui.	Sitara A, Hocq R, Lu AJ, Pflugl S.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02647-0	2025
Transcriptome	Comprehensive Transcriptomic Analysis of Heterotrophic Nitrifying Bacterium Klebsiella sp. TN-10 in Response to Nitrogen Stress.	Li D, Huang M, Dong S, Jin Y, Zhou R, Wu C.	Microorganisms	10.3390/microorganisms10020353	2022
Phylogeny	Expression and Function of Different Guanine-Plus-Cytosine Content 16S rRNA Genes in Haloarcula hispanica at Different Temperatures.	Sato Y, Fujiwara T, Kimura H.	Front Microbiol	10.3389/fmicb.2017.00482	2017
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Genetics	Repurposing the atypical type I-G CRISPR system for bacterial genome engineering.	Shangguan Q, White MF.	Microbiology (Reading)	10.1099/mic.0.001373	2023
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Proteome	New insight in the structural features of haloadaptation in alpha-amylases from halophilic Archaea following homology modeling strategy: folded and stable conformation maintained through low hydrophobicity and highly negative charged surface.	Zorgani MA, Patron K, Desvaux M.	J Comput Aided Mol Des	10.1007/s10822-014-9754-y	2014
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Metabolism	Modified coat protein forms the flexible spindle-shaped virion of haloarchaeal virus His1.	Pietila MK, Atanasova NS, Oksanen HM, Bamford DH.	Environ Microbiol	10.1111/1462-2920.12030	2013
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Genetics	Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficile.	Maikova A, Kreis V, Boutserin A, Severinov K, Soutourina O.	Appl Environ Microbiol	10.1128/aem.01416-19	2019
	DnaQ exonuclease-like domain of Cas2 promotes spacer integration in a type I-E CRISPR-Cas system.	Drabavicius G, Drabavicius G, Sinkunas T, Silanskas A, Gasiunas G, Venclovas C, Siksnys V.	EMBO Rep	10.15252/embr.201745543	2018
	Foreign DNA acquisition by the I-F CRISPR-Cas system requires all components of the interference machinery.	Vorontsova D, Datsenko KA, Medvedeva S, Bondy-Denomy J, Savitskaya EE, Pougach K, Logacheva M, Wiedenheft B, Davidson AR, Severinov K, Semenova E.	Nucleic Acids Res	10.1093/nar/gkv1261	2015
Enzymology	Cas4 Nucleases Can Effect Specific Integration of CRISPR Spacers.	Zhang Z, Pan S, Liu T, Li Y, Peng N.	J Bacteriol	10.1128/jb.00747-18	2019
Enzymology	Molecular Cloning and Characterization of a Novel alpha-Amylase from Antarctic Sea Ice Bacterium Pseudoalteromonas sp. M175 and Its Primary Application in Detergent.	Wang X, Kan G, Ren X, Yu G, Shi C, Xie Q, Wen H, Betenbaugh M.	Biomed Res Int	10.1155/2018/3258383	2018
Genetics	Variation, evolution, and correlation analysis of C+G content and genome or chromosome size in different kingdoms and phyla.	Li XQ, Du D.	PLoS One	10.1371/journal.pone.0088339	2014
	Chloride Activated Halophilic alpha-Amylase from Marinobacter sp. EMB8: Production Optimization and Nanoimmobilization for Efficient Starch Hydrolysis.	Kumar S, Kumar S, Khare SK.	Enzyme Res	10.1155/2015/859485	2015
Metabolism	Distribution and diversity of ribosome binding sites in prokaryotic genomes.	Omotajo D, Tate T, Cho H, Choudhary M.	BMC Genomics	10.1186/s12864-015-1808-6	2015
	Conserved DNA motifs in the type II-A CRISPR leader region.	Van Orden MJ, Klein P, Babu K, Najar FZ, Rajan R.	PeerJ	10.7717/peerj.3161	2017
	Progressive Microbial Community Networks with Incremental Organic Loading Rates Underlie Higher Anaerobic Digestion Performance.	Wu L, Shan X, Chen S, Zhang Q, Qi Q, Qin Z, Yin H, Zhou J, He Q, Yang Y.	mSystems	10.1128/msystems.00357-19	2020
Enzymology	Analysis on evolutionary relationship of amylases from archaea, bacteria and eukaryota.	Yan S, Wu G.	World J Microbiol Biotechnol	10.1007/s11274-015-1979-y	2016
Metabolism	Primed CRISPR DNA uptake in Pyrococcus furiosus.	Garrett S, Shiimori M, Watts EA, Clark L, Graveley BR, Terns MP.	Nucleic Acids Res	10.1093/nar/gkaa381	2020
Genetics	Open Issues for Protein Function Assignment in Haloferax volcanii and Other Halophilic Archaea.	Pfeiffer F, Dyall-Smith M.	Genes (Basel)	10.3390/genes12070963	2021
	Prespacer processing and specific integration in a Type I-A CRISPR system.	Rollie C, Graham S, Rouillon C, White MF.	Nucleic Acids Res	10.1093/nar/gkx1232	2018
Metabolism	Fructose degradation in the haloarchaeon Haloferax volcanii involves a bacterial type phosphoenolpyruvate-dependent phosphotransferase system, fructose-1-phosphate kinase, and class II fructose-1,6-bisphosphate aldolase.	Pickl A, Johnsen U, Schonheit P.	J Bacteriol	10.1128/jb.00200-12	2012
Metabolism	Detection and characterization of spacer integration intermediates in type I-E CRISPR-Cas system.	Arslan Z, Hermanns V, Wurm R, Wagner R, Pul U.	Nucleic Acids Res	10.1093/nar/gku510	2014
	Sequences spanning the leader-repeat junction mediate CRISPR adaptation to phage in Streptococcus thermophilus.	Wei Y, Chesne MT, Terns RM, Terns MP.	Nucleic Acids Res	10.1093/nar/gku1407	2015
Metabolism	DNA binding specificities of Escherichia coli Cas1-Cas2 integrase drive its recruitment at the CRISPR locus.	Moch C, Fromant M, Blanquet S, Plateau P.	Nucleic Acids Res	10.1093/nar/gkw1309	2017
Metabolism	Structural and Functional Studies of a Newly Grouped Haloquadratum walsbyi Bacteriorhodopsin Reveal the Acid-resistant Light-driven Proton Pumping Activity.	Hsu MF, Fu HY, Cai CJ, Yi HP, Yang CS, Wang AH.	J Biol Chem	10.1074/jbc.m115.685065	2015
Metabolism	Key Enzymes of the Semiphosphorylative Entner-Doudoroff Pathway in the Haloarchaeon Haloferax volcanii: Characterization of Glucose Dehydrogenase, Gluconate Dehydratase, and 2-Keto-3-Deoxy-6-Phosphogluconate Aldolase.	Sutter JM, Tastensen JB, Johnsen U, Soppa J, Schonheit P.	J Bacteriol	10.1128/jb.00286-16	2016
Metabolism	Amino acid biosynthesis in the halophilic archaeon Haloarcula hispanica.	Hochuli M, Patzelt H, Oesterhelt D, Wuthrich K, Szyperski T.	J Bacteriol	10.1128/jb.181.10.3226-3237.1999	1999
	An Active Type I-E CRISPR-Cas System Identified in Streptomyces avermitilis.	Qiu Y, Wang S, Chen Z, Guo Y, Song Y.	PLoS One	10.1371/journal.pone.0149533	2016
Metabolism	Identification of the haloarchaeal phasin (PhaP) that functions in polyhydroxyalkanoate accumulation and granule formation in Haloferax mediterranei.	Cai S, Cai L, Liu H, Liu X, Han J, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.07114-11	2012
Metabolism	AglS, a novel component of the Haloferax volcanii N-glycosylation pathway, is a dolichol phosphate-mannose mannosyltransferase.	Cohen-Rosenzweig C, Yurist-Doutsch S, Eichler J.	J Bacteriol	10.1128/jb.01716-12	2012
Enzymology	Metaviromics of Namib Desert Salt Pans: A Novel Lineage of Haloarchaeal Salterproviruses and a Rich Source of ssDNA Viruses.	Adriaenssens EM, van Zyl LJ, Cowan DA, Trindade MI.	Viruses	10.3390/v8010014	2016
	Coupling transcriptional activation of CRISPR-Cas system and DNA repair genes by Csa3a in Sulfolobus islandicus.	Liu T, Liu Z, Ye Q, Pan S, Wang X, Li Y, Peng W, Liang Y, She Q, Peng N.	Nucleic Acids Res	10.1093/nar/gkx612	2017
Metabolism	Methanogens with pseudomurein use diaminopimelate aminotransferase in lysine biosynthesis.	Graham DE, Huse HK.	FEBS Lett	10.1016/j.febslet.2008.03.021	2008
Metabolism	Interaction of two strongly divergent archaellins stabilizes the structure of the Halorubrum archaellum.	Pyatibratov MG, Syutkin AS, Quax TEF, Melnik TN, Papke RT, Gogarten JP, Kireev II, Surin AK, Beznosov SN, Galeva AV, Fedorov OV.	Microbiologyopen	10.1002/mbo3.1047	2020
	Priming in the Type I-F CRISPR-Cas system triggers strand-independent spacer acquisition, bi-directionally from the primed protospacer.	Richter C, Dy RL, McKenzie RE, Watson BN, Taylor C, Chang JT, McNeil MB, Staals RH, Fineran PC.	Nucleic Acids Res	10.1093/nar/gku527	2014
Metabolism	Characterization of the archaeal thermophile Sulfolobus turreted icosahedral virus validates an evolutionary link among double-stranded DNA viruses from all domains of life.	Maaty WS, Ortmann AC, Dlakic M, Schulstad K, Hilmer JK, Liepold L, Weidenheft B, Khayat R, Douglas T, Young MJ, Bothner B.	J Virol	10.1128/jvi.00522-06	2006
Metabolism	Haloarchaeal-type beta-ketothiolases involved in Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) synthesis in Haloferax mediterranei.	Hou J, Feng B, Han J, Liu H, Zhao D, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.01370-13	2013
Genetics	Virioplankton community structure in Tunisian solar salterns.	Boujelben I, Yarza P, Almansa C, Villamor J, Maalej S, Anton J, Santos F.	Appl Environ Microbiol	10.1128/aem.01793-12	2012
Genetics	Snapshot of haloarchaeal tailed virus genomes.	Sencilo A, Jacobs-Sera D, Russell DA, Ko CC, Bowman CA, Atanasova NS, Osterlund E, Oksanen HM, Bamford DH, Hatfull GF, Roine E, Hendrix RW.	RNA Biol	10.4161/rna.24045	2013
Metabolism	Multiple propionyl coenzyme A-supplying pathways for production of the bioplastic poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Haloferax mediterranei.	Han J, Hou J, Zhang F, Ai G, Li M, Cai S, Liu H, Wang L, Wang Z, Zhang S, Cai L, Zhao D, Zhou J, Xiang H.	Appl Environ Microbiol	10.1128/aem.03915-12	2013
Metabolism	Importance of uncharged polar residues and proline in the proximal two-thirds (Pro107-Ser128) of the highly conserved region of mouse ileal Na+-dependent bile acid transporter, Slc10a2, in transport activity and cellular expression.	Saeki T, Sato K, Ito S, Ikeda K, Kanamoto R.	BMC Physiol	10.1186/1472-6793-13-4	2013
	Development of additional selectable markers for the halophilic archaeon Haloferax volcanii based on the leuB and trpA genes.	Allers T, Ngo HP, Mevarech M, Lloyd RG.	Appl Environ Microbiol	10.1128/aem.70.2.943-953.2004	2004
Metabolism	Analysis of the transcriptional regulator GlpR, promoter elements, and posttranscriptional processing involved in fructose-induced activation of the phosphoenolpyruvate-dependent sugar phosphotransferase system in Haloferax mediterranei.	Cai L, Cai S, Zhao D, Wu J, Wang L, Liu X, Li M, Hou J, Zhou J, Liu J, Han J, Xiang H.	Appl Environ Microbiol	10.1128/aem.03372-13	2014
	The complete genome sequence of Natrinema sp. J7-2, a haloarchaeon capable of growth on synthetic media without amino acid supplements.	Feng J, Liu B, Zhang Z, Ren Y, Li Y, Gan F, Huang Y, Chen X, Shen P, Wang L, Tang B, Tang XF.	PLoS One	10.1371/journal.pone.0041621	2012
	Generation of comprehensive transposon insertion mutant library for the model archaeon, Haloferax volcanii, and its use for gene discovery.	Kiljunen S, Pajunen MI, Dilks K, Storf S, Pohlschroder M, Savilahti H.	BMC Biol	10.1186/s12915-014-0103-3	2014
	Choosing a suitable method for the identification of replication origins in microbial genomes.	Song C, Zhang S, Huang H.	Front Microbiol	10.3389/fmicb.2015.01049	2015
Phylogeny	Archaeal diversity at the great salt plains of Oklahoma described by cultivation and molecular analyses.	Caton TM, Caton IR, Witte LR, Schneegurt MA.	Microb Ecol	10.1007/s00248-009-9507-y	2009
	Degenerate target sites mediate rapid primed CRISPR adaptation.	Fineran PC, Gerritzen MJ, Suarez-Diez M, Kunne T, Boekhorst J, van Hijum SA, Staals RH, Brouns SJ.	Proc Natl Acad Sci U S A	10.1073/pnas.1400071111	2014
Metabolism	Archaeal cell surface biogenesis.	Pohlschroder M, Pfeiffer F, Schulze S, Abdul Halim MF.	FEMS Microbiol Rev	10.1093/femsre/fuy027	2018
Metabolism	Environmental salinity determines the specificity and need for Tat-dependent secretion of the YwbN protein in Bacillus subtilis.	van der Ploeg R, Mader U, Homuth G, Schaffer M, Denham EL, Monteferrante CG, Miethke M, Marahiel MA, Harwood CR, Winter T, Hecker M, Antelmann H, van Dijl JM.	PLoS One	10.1371/journal.pone.0018140	2011
	TPV1, the first virus isolated from the hyperthermophilic genus Thermococcus.	Gorlas A, Koonin EV, Bienvenu N, Prieur D, Geslin C.	Environ Microbiol	10.1111/j.1462-2920.2011.02662.x	2012
Genetics	Reconstructing viral genomes from the environment using fosmid clones: the case of haloviruses.	Garcia-Heredia I, Martin-Cuadrado AB, Mojica FJ, Santos F, Mira A, Anton J, Rodriguez-Valera F.	PLoS One	10.1371/journal.pone.0033802	2012
	CRISPR interference and priming varies with individual spacer sequences.	Xue C, Seetharam AS, Musharova O, Severinov K, Brouns SJ, Severin AJ, Sashital DG.	Nucleic Acids Res	10.1093/nar/gkv1259	2015
Metabolism	The primordial metabolism: an ancestral interconnection between leucine, arginine, and lysine biosynthesis.	Fondi M, Brilli M, Emiliani G, Paffetti D, Fani R.	BMC Evol Biol	10.1186/1471-2148-7-s2-s3	2007
	Phages in nature.	Clokie MR, Millard AD, Letarov AV, Heaphy S.	Bacteriophage	10.4161/bact.1.1.14942	2011
Metabolism	Box C/D RNA guides for the ribose methylation of archaeal tRNAs. The tRNATrp intron guides the formation of two ribose-methylated nucleosides in the mature tRNATrp.	Clouet d'Orval B, Bortolin ML, Gaspin C, Bachellerie JP.	Nucleic Acids Res	10.1093/nar/29.22.4518	2001
Enzymology	Sequence analysis of an Archaeal virus isolated from a hypersaline lake in Inner Mongolia, China.	Pagaling E, Haigh RD, Grant WD, Cowan DA, Jones BE, Ma Y, Ventosa A, Heaphy S.	BMC Genomics	10.1186/1471-2164-8-410	2007
Enzymology	Genetic and proteomic analyses of a proteasome-activating nucleotidase A mutant of the haloarchaeon Haloferax volcanii.	Kirkland PA, Gil MA, Karadzic IM, Maupin-Furlow JA.	J Bacteriol	10.1128/jb.01196-07	2008
Metabolism	In vivo analysis of an essential archaeal signal recognition particle in its native host.	Rose RW, Pohlschroder M.	J Bacteriol	10.1128/jb.184.12.3260-3267.2002	2002
Metabolism	Metabolism of halophilic archaea.	Falb M, Muller K, Konigsmaier L, Oberwinkler T, Horn P, von Gronau S, Gonzalez O, Pfeiffer F, Bornberg-Bauer E, Oesterhelt D.	Extremophiles	10.1007/s00792-008-0138-x	2008
Genetics	Whole-genome comparison between the type strain of Halobacterium salinarum (DSM 3754^T ) and the laboratory strains R1 and NRC-1.	Pfeiffer F, Losensky G, Marchfelder A, Habermann B, Dyall-Smith M.	Microbiologyopen	10.1002/mbo3.974	2020
	Insertion sequence diversity in archaea.	Filee J, Siguier P, Chandler M.	Microbiol Mol Biol Rev	10.1128/mmbr.00031-06	2007
	Novel Insights Into the Sulfated Glucuronic Acid-Based Anti-SARS-CoV-2 Mechanism of Exopolysaccharides From Halophilic Archaeon Haloarcula hispanica.	Xu Y, Li Y, You X, Pei C, Wang Z, Jiao S, Zhao X, Lin X, Lu Y, Jin C, Gao GF, Li J, Wang Q, Du Y	Front Chem	10.3389/fchem.2022.871509	2022
Genetics	Genome Sequence of Hardyhisp2, a Gammapleolipovirus Infecting Haloarcula hispanica.	Dyall-Smith M, Pfeiffer F, Chiang PW, Tang SL	Microbiol Resour Announc	10.1128/MRA.00226-21	2021
	An Acidic Exopolysaccharide from Haloarcula hispanica ATCC33960 and Two Genes Responsible for Its Synthesis.	Lu Y, Lu H, Wang S, Han J, Xiang H, Jin C	Archaea	10.1155/2017/5842958	2017
Genetics	Complete Genome Sequence of the Extremely Halophilic Archaeon Haloarcula hispanica Strain N601.	Ding JY, Chiang PW, Hong MJ, Dyall-Smith M, Tang SL	Genome Announc	10.1128/genomeA.00178-14	2014
Enzymology	New food for an old mouth: new enzyme for an ancient archaea.	Oztetik E, Cakir A	Enzyme Microb Technol	10.1016/j.enzmictec.2013.12.004	2013
Metabolism	Construction of a novel shuttle vector based on an RCR-plasmid from a haloalkaliphilic archaeon and transformation into other haloarchaea.	Zhou M, Xiang H, Sun C, Tan H	Biotechnol Lett	10.1023/B:BILE.0000035493.21986.20	2004
Phylogeny	Phylogenetic analyses of some extremely halophilic archaea isolated from Dead Sea water, determined on the basis of their 16S rRNA sequences.	Arahal DR, Dewhirst FE, Paster BJ, Volcani BE, Ventosa A	Appl Environ Microbiol	10.1128/aem.62.10.3779-3786.1996	1996
Genetics	Genome-Based Reclassification of Two Haloarcula Species and Characterization of Haloarcula montana sp. nov.	Liu JQ, Zhu LR, Mao YL, Ma X, Hou J.	Biology (Basel)	10.3390/biology14060615	2025
Phylogeny	Haloarcula mannanilytica sp. nov., a galactomannan-degrading haloarchaeon isolated from commercial salt.	Enomoto S, Shimane Y, Ihara K, Kamekura M, Itoh T, Ohkuma M, Takahashi-Ando N, Fukushima Y, Yoshida Y, Usami R, Takai K, Minegishi H	Int J Syst Evol Microbiol	10.1099/ijsem.0.004535	2020

References

#1665	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 4426
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Haloarcula hispanica (DSM 4426, ATCC 33960, NCMB 2187)

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