Hydrogenobacter thermophilus (DSM 6534, IAM 12695, TK-6)

Name: Hydrogenobacter thermophilus (DSM 6534, IAM 12695, TK-6)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 512

Type strain

Strain Designation TK-6

Culture col. no. DSM 6534 IAM 12695 TK-6 JCM 7687 NBRC 102181

NCBI tax ID(s) 608538 940

Special Collections DSMZ JCM Literature strains

History DSMZ <- T. Kodama, TK-6 JCM <-- T. Kodama TK-6.

Links

Hydrogenobacter thermophilus TK-6 is an aerobe, chemolithotroph, Gram-negative bacterium that was isolated from hot springs.

Gram-negative rod-shaped aerobe chemolithotroph genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 323294

DSM 6534,IAM 12695,JCM 7687,NBRC 102181

@ref 20215

Last LPSN update 2026-05-29 08:25:03

Domain Bacteria

Phylum Aquificota

Class Aquificia

Order Aquificales

Family Aquificaceae

Genus Hydrogenobacter

Species Hydrogenobacter thermophilus

Full scientific name Hydrogenobacter thermophilus Kawasumi et al. 1984

Morphology

Cell morphology

@ref	Gram stain	Cell length	Cell width	Cell shape	Motility	Confidence
23128	negative	2.0-3.0 µm	0.3-0.5 µm	rod-shaped
125438	negative					96.711

Multimedia

@ref:	66793
multimedia content:	EM_DSM_6534_1.jpg
multimedia.multimedia content:	EM_DSM_6534_1.jpg
caption:	electron microscopic image
intellectual property rights:	© HZI/Manfred Rohde
manual_annotation:	1

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
2720	MINERAL MEDIUM FOR CHEMOLITHOTROPHIC GROWTH (H-3) (DSMZ Medium 81)		Medium recipe at MediaDive	Name: MINERAL MEDIUM FOR CHEMOLITHOTROPHIC GROWTH (H-3) (DSMZ Medium 81) Composition: Agar 20.1005 g/l Na2HPO4 x 2 H2O 2.91457 g/l KH2PO4 2.31156 g/l NH4Cl 1.00503 g/l MgSO4 x 7 H2O 0.502512 g/l Ferric ammonium citrate 0.0502513 g/l CaCl2 x 2 H2O 0.0100503 g/l NaVO3 x H2O 0.00502512 g/l Calcium pantothenate 0.00251256 g/l Pyridoxine hydrochloride 0.00251256 g/l Nicotinic acid 0.00251256 g/l Thiamine-HCl x 2 H2O 0.00251256 g/l H3BO3 0.00150754 g/l CoCl2 x 6 H2O 0.00100503 g/l Riboflavin 0.000502513 g/l ZnSO4 x 7 H2O 0.000502513 g/l MnCl2 x 4 H2O 0.000150754 g/l Na2MoO4 x 2 H2O 0.000150754 g/l NiCl2 x 6 H2O 0.000100503 g/l CuCl2 x 2 H2O 5.02513e-05 g/l Vitamin B12 5.02513e-05 g/l Folic acid 1.00503e-05 g/l Biotin 5.02513e-06 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
2720	positive	growth	70
23128	negative	growth	37
23128	negative	growth	80
23128	positive	optimum	70-75
67770	positive	growth	70

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
23128	aerobe
125439	anaerobe	95.443

Nutrition type

23128

Typechemolithotroph

Spore formation

@ref	Spore formation	Confidence
23128
125438		91.872

Observation

67770

Observationquinones: Methionaquinone (MTK)-7(VI,VII-H₄)

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
23128	30916 ChEBI	2-oxoglutarate	-	carbon source
23128	30916 ChEBI	2-oxoglutarate	-	energy source
23128	37054 ChEBI	3-hydroxybutyrate	-	carbon source
23128	37054 ChEBI	3-hydroxybutyrate	-	energy source
23128	17879 ChEBI	4-hydroxybenzoate	-	carbon source
23128	17879 ChEBI	4-hydroxybenzoate	-	energy source
23128	30089 ChEBI	acetate	-	carbon source
23128	30089 ChEBI	acetate	-	energy source
23128	17750 ChEBI	betaine	-	carbon source
23128	17750 ChEBI	betaine	-	energy source
23128	16947 ChEBI	citrate	-	carbon source
23128	16947 ChEBI	citrate	-	energy source
23128	16024 ChEBI	D-mannose	-	carbon source
23128	16024 ChEBI	D-mannose	-	energy source
23128	16551 ChEBI	D-trehalose	-	carbon source
23128	16551 ChEBI	D-trehalose	-	energy source
23128	17170 ChEBI	dimethylamine	-	carbon source
23128	17170 ChEBI	dimethylamine	-	energy source
23128	16236 ChEBI	ethanol	-	carbon source
23128	16236 ChEBI	ethanol	-	energy source
23128	15740 ChEBI	formate	-	carbon source
23128	15740 ChEBI	formate	-	energy source
23128	28757 ChEBI	fructose	-	carbon source
23128	28757 ChEBI	fructose	-	energy source
23128	29806 ChEBI	fumarate	-	carbon source
23128	29806 ChEBI	fumarate	-	energy source
23128	28260 ChEBI	galactose	-	carbon source
23128	28260 ChEBI	galactose	-	energy source
23128	24265 ChEBI	gluconate	-	carbon source
23128	24265 ChEBI	gluconate	-	energy source
23128	17234 ChEBI	glucose	-	carbon source
23128	17234 ChEBI	glucose	-	energy source
23128	15428 ChEBI	glycine	-	carbon source
23128	15428 ChEBI	glycine	-	energy source
23128	29805 ChEBI	glycolate	-	carbon source
23128	29805 ChEBI	glycolate	-	energy source
23128	16977 ChEBI	L-alanine	-	carbon source
23128	16977 ChEBI	L-alanine	-	energy source
23128	16467 ChEBI	L-arginine	-	carbon source
23128	16467 ChEBI	L-arginine	-	energy source
23128	29991 ChEBI	L-aspartate	-	carbon source
23128	29991 ChEBI	L-aspartate	-	energy source
23128	29985 ChEBI	L-glutamate	-	carbon source
23128	29985 ChEBI	L-glutamate	-	energy source
23128	15971 ChEBI	L-histidine	-	carbon source
23128	15971 ChEBI	L-histidine	-	energy source
23128	15603 ChEBI	L-leucine	-	carbon source
23128	15603 ChEBI	L-leucine	-	energy source
23128	18019 ChEBI	L-lysine	-	carbon source
23128	18019 ChEBI	L-lysine	-	energy source
23128	17203 ChEBI	L-proline	-	carbon source
23128	17203 ChEBI	L-proline	-	energy source
23128	62345 ChEBI	L-rhamnose	-	carbon source
23128	62345 ChEBI	L-rhamnose	-	energy source
23128	17115 ChEBI	L-serine	-	carbon source
23128	17115 ChEBI	L-serine	-	energy source
23128	16828 ChEBI	L-tryptophan	-	carbon source
23128	16828 ChEBI	L-tryptophan	-	energy source
23128	16414 ChEBI	L-valine	-	carbon source
23128	16414 ChEBI	L-valine	-	energy source
23128	24996 ChEBI	lactate	-	carbon source
23128	24996 ChEBI	lactate	-	energy source
23128	25115 ChEBI	malate	-	carbon source
23128	25115 ChEBI	malate	-	energy source
23128	18300 ChEBI	maleic acid	-	carbon source
23128	18300 ChEBI	maleic acid	-	energy source
23128	17306 ChEBI	maltose	-	carbon source
23128	17306 ChEBI	maltose	-	energy source
23128	29864 ChEBI	mannitol	-	carbon source
23128	29864 ChEBI	mannitol	-	energy source
23128	17790 ChEBI	methanol	-	carbon source
23128	17790 ChEBI	methanol	-	energy source
23128	16830 ChEBI	methylamine	-	carbon source
23128	16830 ChEBI	methylamine	-	energy source
23128	17272 ChEBI	propionate	-	carbon source
23128	17272 ChEBI	propionate	-	energy source
23128	15361 ChEBI	pyruvate	-	carbon source
23128	15361 ChEBI	pyruvate	-	energy source
23128	16634 ChEBI	raffinose	-	carbon source
23128	16634 ChEBI	raffinose	-	energy source
23128	28017 ChEBI	starch	-	carbon source
23128	28017 ChEBI	starch	-	energy source
23128	30031 ChEBI	succinate	-	carbon source
23128	30031 ChEBI	succinate	-	energy source
23128	17992 ChEBI	sucrose	-	carbon source
23128	17992 ChEBI	sucrose	-	energy source
23128	18139 ChEBI	trimethylamine	-	carbon source
23128	18139 ChEBI	trimethylamine	-	energy source
23128	18222 ChEBI	xylose	-	carbon source
23128	18222 ChEBI	xylose	-	energy source
23128		yeast extract	-	carbon source
23128		yeast extract	-	energy source

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	ppGpp biosynthesis	100	4 of 4
66794	cardiolipin biosynthesis	100	7 of 7
66794	coenzyme A metabolism	100	4 of 4
66794	sulfopterin metabolism	100	4 of 4
66794	denitrification	100	2 of 2
66794	hydrogen production	100	5 of 5
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	methylglyoxal degradation	100	5 of 5
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	suberin monomers biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	folate polyglutamylation	100	1 of 1
66794	biotin biosynthesis	100	4 of 4
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	palmitate biosynthesis	95.45	21 of 22
66794	chorismate metabolism	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	pentose phosphate pathway	81.82	9 of 11
66794	peptidoglycan biosynthesis	80	12 of 15
66794	threonine metabolism	80	8 of 10
66794	flavin biosynthesis	80	12 of 15
66794	lipoate biosynthesis	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	tetrahydrofolate metabolism	78.57	11 of 14
66794	molybdenum cofactor biosynthesis	77.78	7 of 9
66794	nitrate assimilation	77.78	7 of 9
66794	lipid A biosynthesis	77.78	7 of 9
66794	phenylalanine metabolism	76.92	10 of 13
66794	isoleucine metabolism	75	6 of 8
66794	acetate fermentation	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	CMP-KDO biosynthesis	75	3 of 4
66794	ubiquinone biosynthesis	71.43	5 of 7
66794	heme metabolism	71.43	10 of 14
66794	vitamin B1 metabolism	69.23	9 of 13
66794	purine metabolism	68.09	64 of 94
66794	serine metabolism	66.67	6 of 9
66794	acetoin degradation	66.67	2 of 3
66794	selenocysteine biosynthesis	66.67	4 of 6
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	octane oxidation	66.67	2 of 3
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	citric acid cycle	64.29	9 of 14
66794	glutamate and glutamine metabolism	64.29	18 of 28
66794	vitamin B6 metabolism	63.64	7 of 11
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	pyrimidine metabolism	62.22	28 of 45
66794	starch degradation	60	6 of 10
66794	glycogen metabolism	60	3 of 5
66794	d-mannose degradation	55.56	5 of 9
66794	proline metabolism	54.55	6 of 11
66794	sulfate reduction	53.85	7 of 13
66794	glycolysis	52.94	9 of 17
66794	alanine metabolism	51.72	15 of 29
66794	ethanol fermentation	50	1 of 2
66794	adipate degradation	50	1 of 2
66794	gluconeogenesis	50	4 of 8
66794	1,4-dihydroxy-6-naphthoate biosynthesis	50	3 of 6
66794	non-pathway related	50	19 of 38
66794	pantothenate biosynthesis	50	3 of 6
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	C4 and CAM-carbon fixation	50	4 of 8
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	glycine metabolism	50	5 of 10
66794	phenylmercury acetate degradation	50	1 of 2
66794	ketogluconate metabolism	50	4 of 8
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	methionine metabolism	50	13 of 26
66794	histidine metabolism	48.28	14 of 29
66794	urea cycle	46.15	6 of 13
66794	oxidative phosphorylation	46.15	42 of 91
66794	leucine metabolism	46.15	6 of 13
66794	isoprenoid biosynthesis	46.15	12 of 26
66794	arginine metabolism	45.83	11 of 24
66794	metabolism of disaccharids	45.45	5 of 11
66794	propanol degradation	42.86	3 of 7
66794	tryptophan metabolism	42.11	16 of 38
66794	lysine metabolism	40.48	17 of 42
66794	glycine betaine biosynthesis	40	2 of 5
66794	coenzyme M biosynthesis	40	4 of 10
66794	propionate fermentation	40	4 of 10
66794	degradation of aromatic, nitrogen containing compounds	33.33	4 of 12
66794	IAA biosynthesis	33.33	1 of 3
66794	CO2 fixation in Crenarchaeota	33.33	3 of 9
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	degradation of hexoses	33.33	6 of 18
66794	cysteine metabolism	33.33	6 of 18
66794	degradation of pentoses	32.14	9 of 28
66794	myo-inositol biosynthesis	30	3 of 10
66794	tyrosine metabolism	28.57	4 of 14
66794	glutathione metabolism	28.57	4 of 14
66794	methanogenesis from CO2	25	3 of 12
66794	carnitine metabolism	25	2 of 8
66794	lactate fermentation	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	butanoate fermentation	25	1 of 4
66794	dTDPLrhamnose biosynthesis	25	2 of 8
66794	ascorbate metabolism	22.73	5 of 22
66794	lipid metabolism	22.58	7 of 31
66794	chlorophyll metabolism	22.22	4 of 18

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Aquatic	#Thermal spring
#Condition	#Thermophilic (>45°C)	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
2720	hot springs	Izu, Kyushu	Japan	JPN	Asia
67770	Soil near hot-spring in Izu Peninsula		Japan	JPN	Asia

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
2720	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1078v1 assembly for Hydrogenobacter thermophilus TK-6	complete	GCA_000010785	608538.3	646311936	608538	95.73
66792	ASM16490v1 assembly for Hydrogenobacter thermophilus TK-6	complete	GCA_000164905	608538.5	650377953	608538	95.7

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
2720	H.thermophilus TK-6 (IAM-12695) 16S ribosomal RNA	Z30214	1513		608538

GC content

@ref	GC-content (mol%)	Method
67770	43.7	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM1078v1 assembly for Hydrogenobacter thermophilus TK-6
BV-BRC: 608538.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	95.44	no
125439	gram_stain	BacteriaNetⓘ	variable	45.87	no
125439	motility	BacteriaNetⓘ	no	78.37	no
125439	spore_formation	BacteriaNetⓘ	no	84.87	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Hydrogenobacter thermophilus TK-6 TK-6
NCBI: GCA_000164905.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	96.71	yes
125438	anaerobic	anaerobicⓘ	no	50.74	no
125438	aerobic	aerobicⓘ	no	78.55	no
125438	spore-forming	spore-formingⓘ	no	91.87	yes
125438	thermophilic	thermophileⓘ	yes	77.36	yes
125438	flagellated	motile2+ⓘ	no	74.01	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Phosphoserine Phosphatase Is Required for Serine and One-Carbon Unit Synthesis in Hydrogenobacter thermophilus.	Kim K, Chiba Y, Kobayashi A, Arai H, Ishii M.	J Bacteriol	10.1128/jb.00409-17	2017
Metabolism	Discovery and analysis of cofactor-dependent phosphoglycerate mutase homologs as novel phosphoserine phosphatases in Hydrogenobacter thermophilus.	Chiba Y, Oshima K, Arai H, Ishii M, Igarashi Y.	J Biol Chem	10.1074/jbc.m111.330621	2012
Metabolism	A novel enzymatic system against oxidative stress in the thermophilic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus.	Sato Y, Kameya M, Fushinobu S, Wakagi T, Arai H, Ishii M, Igarashi Y.	PLoS One	10.1371/journal.pone.0034825	2012
	Changes in quinone profiles of hot spring microbial mats with a thermal gradient	Hiraishi A, Umezawa T, Yamamoto H, Kato K, Maki Y.	Appl Environ Microbiol	10.1128/aem.65.1.198-205.1999	1999
Phylogeny	Nitrogenase Activity in Thermophilic Chemolithoautotrophic Bacteria in the Phylum Aquificae Isolated under Nitrogen-Fixing Conditions from Nakabusa Hot Springs.	Nishihara A, Matsuura K, Tank M, McGlynn SE, Thiel V, Haruta S	Microbes Environ	10.1264/jsme2.ME18041	2018
Metabolism	Structural units important for activity of a novel-type phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6 revealed by crystal structure analysis.	Chiba Y, Horita S, Ohtsuka J, Arai H, Nagata K, Igarashi Y, Tanokura M, Ishii M	J Biol Chem	10.1074/jbc.M112.449561	2013
Enzymology	Crystallization and preliminary X-ray diffraction analysis of a novel type of phosphoserine phosphatase from Hydrogenobacter thermophilus TK-6.	Chiba Y, Horita S, Ohtsuka J, Arai H, Nagata K, Igarashi Y, Tanokura M, Ishii M	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/S1744309112025213	2012
Genetics	Complete genome sequence of Hydrogenobacter thermophilus type strain (TK-6).	Zeytun A, Sikorski J, Nolan M, Lapidus A, Lucas S, Han J, Tice H, Cheng JF, Tapia R, Goodwin L, Pitluck S, Liolios K, Ivanova N, Mavromatis K, Mikhailova N, Ovchinnikova G, Pati A, Chen A, Palaniappan K, Ngatchou-Djao OD, Land M, Hauser L, Jeffries CD, Han C, Detter JC, Ubler S, Rohde M, Tindall BJ, Goker M, Wirth R, Woyke T, Bristow J, Eisen JA, Markowitz V, Hugenholtz P, Klenk HP, Kyrpides NC	Stand Genomic Sci	10.4056/sigs.1463589	2011
Genetics	Complete genome sequence of the thermophilic, obligately chemolithoautotrophic hydrogen-oxidizing bacterium Hydrogenobacter thermophilus TK-6.	Arai H, Kanbe H, Ishii M, Igarashi Y	J Bacteriol	10.1128/JB.00158-10	2010
Enzymology	Purification of three aminotransferases from Hydrogenobacter thermophilus TK-6--novel types of alanine or glycine aminotransferase: enzymes and catalysis.	Kameya M, Arai H, Ishii M, Igarashi Y	FEBS J	10.1111/j.1742-4658.2010.07604.x	2010
Metabolism	Enzymatic and electron paramagnetic resonance studies of anabolic pyruvate synthesis by pyruvate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus.	Ikeda T, Yamamoto M, Arai H, Ohmori D, Ishii M, Igarashi Y	FEBS J	10.1111/j.1742-4658.2009.07506.x	2009
Enzymology	Carboxylation reaction catalyzed by 2-oxoglutarate:ferredoxin oxidoreductases from Hydrogenobacter thermophilus.	Yamamoto M, Ikeda T, Arai H, Ishii M, Igarashi Y	Extremophiles	10.1007/s00792-009-0289-4	2009
Enzymology	Ferredoxin-NADP reductase from the thermophilic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.	Ikeda T, Nakamura M, Arai H, Ishii M, Igarashi Y	FEMS Microbiol Lett	10.1111/j.1574-6968.2009.01667.x	2009
Genetics	A soluble NADH-dependent fumarate reductase in the reductive tricarboxylic acid cycle of Hydrogenobacter thermophilus TK-6.	Miura A, Kameya M, Arai H, Ishii M, Igarashi Y	J Bacteriol	10.1128/JB.00747-08	2008
Enzymology	Sequencing and reverse transcription-polymerase chain reaction (RT-PCR) analysis of four hydrogenase gene clusters from an obligately autotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.	Ueda Y, Yamamoto M, Urasaki T, Arai H, Ishii M, Igarashi Y	J Biosci Bioeng	10.1263/jbb.104.470	2007
Enzymology	A novel ferredoxin-dependent glutamate synthase from the hydrogen-oxidizing chemoautotrophic bacterium Hydrogenobacter thermophilus TK-6.	Kameya M, Ikeda T, Nakamura M, Arai H, Ishii M, Igarashi Y	J Bacteriol	10.1128/JB.01360-06	2007
Enzymology	Purification and properties of glutamine synthetase from Hydrogenobacter thermophilus TK-6.	Kameya M, Arai H, Ishii M, Igarashi Y	J Biosci Bioeng	10.1263/jbb.102.311	2006
Metabolism	A novel oxalosuccinate-forming enzyme involved in the reductive carboxylation of 2-oxoglutarate in Hydrogenobacter thermophilus TK-6.	Aoshima M, Igarashi Y	Mol Microbiol	10.1111/j.1365-2958.2006.05399.x	2006
Metabolism	Role of two 2-oxoglutarate:ferredoxin oxidoreductases in Hydrogenobacter thermophilus under aerobic and anaerobic conditions.	Yamamoto M, Arai H, Ishii M, Igarashi Y	FEMS Microbiol Lett	10.1111/j.1574-6968.2006.00415.x	2006
Metabolism	Gene structure and expression profile of cytochrome bc nitric oxide reductase from Hydrogenobacter thermophilus TK-6.	Suzuki M, Arai H, Ishii M, Igarashi Y	Biosci Biotechnol Biochem	10.1271/bbb.60018	2006
Enzymology	Purification, characterization, and gene cloning of thermophilic cytochrome cd1 nitrite reductase from Hydrogenobacter thermophilus TK-6.	Suzuki M, Hirai T, Arai H, Ishii M, Igarashi Y	J Biosci Bioeng	10.1263/jbb.101.391	2006
Genetics	Anabolic five subunit-type pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.	Ikeda T, Ochiai T, Morita S, Nishiyama A, Yamada E, Arai H, Ishii M, Igarashi Y	Biochem Biophys Res Commun	10.1016/j.bbrc.2005.11.155	2005
Genetics	Two tandemly arranged ferredoxin genes in the Hydrogenobacter thermophilus genome: comparative characterization of the recombinant [4Fe-4S] ferredoxins.	Ikeda T, Yamamoto M, Arai H, Ohmori D, Ishii M, Igarashi Y	Biosci Biotechnol Biochem	10.1271/bbb.69.1172	2005
Metabolism	A novel enzyme, citryl-CoA lyase, catalysing the second step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.	Aoshima M, Ishii M, Igarashi Y	Mol Microbiol	10.1111/j.1365-2958.2004.04010.x	2004
Metabolism	A novel enzyme, citryl-CoA synthetase, catalysing the first step of the citrate cleavage reaction in Hydrogenobacter thermophilus TK-6.	Aoshima M, Ishii M, Igarashi Y	Mol Microbiol	10.1111/j.1365-2958.2004.04009.x	2004
Enzymology	A novel biotin protein required for reductive carboxylation of 2-oxoglutarate by isocitrate dehydrogenase in Hydrogenobacter thermophilus TK-6.	Aoshima M, Ishii M, Igarashi Y	Mol Microbiol	10.1046/j.1365-2958.2003.03863.x	2004
Enzymology	Characterization of two different 2-oxoglutarate:ferredoxin oxidoreductases from Hydrogenobacter thermophilus TK-6.	Yamamoto M, Arai H, Ishii M, Igarashi Y	Biochem Biophys Res Commun	10.1016/j.bbrc.2003.11.078	2003
Enzymology	A novel five-subunit-type 2-oxoglutalate:ferredoxin oxidoreductases from Hydrogenobacter thermophilus TK-6.	Yun NR, Yamamoto M, Arai H, Ishii M, Igarashi Y	Biochem Biophys Res Commun	10.1006/bbrc.2002.6651	2002
Phylogeny	Signature lipids and stable carbon isotope analyses of Octopus Spring hyperthermophilic communities compared with those of Aquificales representatives.	Jahnke LL, Eder W, Huber R, Hope JM, Hinrichs KU, Hayes JM, Des Marais DJ, Cady SL, Summons RE	Appl Environ Microbiol	10.1128/AEM.67.11.5179-5189.2001	2001
Enzymology	Chemical structure of a novel aminophospholipid from Hydrogenobacter thermophilus strain TK-6.	Yoshino J, Sugiyama Y, Sakuda S, Kodama T, Nagasawa H, Ishii M, Igarashi Y	J Bacteriol	10.1128/JB.183.21.6302-6304.2001	2001
Enzymology	The genes for anabolic 2-oxoglutarate: ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.	Yun NR, Arai H, Ishii M, Igarashi Y	Biochem Biophys Res Commun	10.1006/bbrc.2001.4542	2001
Metabolism	Nitrate respiratory metabolism in an obligately autotrophic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus TK-6.	Suzuki M, Cui ZJ, Ishii M, Igarashi Y	Arch Microbiol	10.1007/s002030000230	2001
Enzymology	Purification and characterization of membrane-bound hydrogenase from Hydrogenobacter thermophilus strain TK-6, an obligately autotrophic, thermophilic, hydrogen-oxidizing bacterium.	Ishii M, Takishita S, Iwasaki T, Peerapornpisal Y, Yoshino J, Kodama T, Igarashi Y	Biosci Biotechnol Biochem	10.1271/bbb.64.492	2000
Enzymology	Purification and characterization of pyruvate:ferredoxin oxidoreductase from Hydrogenobacter thermophilus TK-6.	Yoon KS, Ishii M, Kodama T, Igarashi Y	Arch Microbiol	10.1007/s002030050443	1997
Enzymology	Purification and characterization of ferredoxin from Hydrogenobacter thermophilus strain TK-6.	Ishii M, Ueda Y, Yoon KS, Igarashi Y, Kodama T	Biosci Biotechnol Biochem	10.1271/bbb.60.1513	1996
Enzymology	Purification and characterization of 2-oxoglutarate:ferredoxin oxidoreductase from a thermophilic, obligately chemolithoautotrophic bacterium, Hydrogenobacter thermophilus TK-6.	Yoon KS, Ishii M, Igarashi Y, Kodama T	J Bacteriol	10.1128/jb.178.11.3365-3368.1996	1996
Phylogeny	Phylogenetic position of the genus Hydrogenobacter.	Pitulle C, Yang Y, Marchiani M, Moore ER, Siefert JL, Aragno M, Jurtshuk P Jr, Fox GE	Int J Syst Bacteriol	10.1099/00207713-44-4-620	1994
Enzymology	Purification and characterization of ATP:citrate lyase from Hydrogenobacter thermophilus TK-6.	Ishii M, Igarashi Y, Kodama T	J Bacteriol	10.1128/jb.171.4.1788-1792.1989	1989
Phylogeny	Amino acid sequence of cytochrome c-552 from a thermophilic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus.	Sanbongi Y, Ishii M, Igarashi Y, Kodama T	J Bacteriol	10.1128/jb.171.1.65-69.1989	1989
Enzymology	2-Methylthio-1,4-naphthoquinone, a unique sulfur-containing quinone from a thermophilic hydrogen-oxidizing bacterium, Hydrogenobacter thermophilus.	Ishii M, Kawasumi T, Igarashi Y, Kodama T, Minoda Y	J Bacteriol	10.1128/jb.169.6.2380-2384.1987	1987
	Thermocrinis ruber gen. nov., sp. nov., A pink-filament-forming hyperthermophilic bacterium isolated from yellowstone national park	Huber R, Eder W, Heldwein S, Wanner G, Huber H, Rachel R, Stetter KO.	Appl Environ Microbiol	10.1128/aem.64.10.3576-3583.1998	1998

References

#2720	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 6534
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#23128	Toshiyuki Kawasumi, Yasuo Igarashi, Tohru Kodama, Yasuji Minoda: Hydrogenobacter thermophilus gen. nov., sp. nov., an Extremely Thermophilic, Aerobic, Hydrogen-Oxidizing Bacterium. IJSEM 34: 5 - 10 1984 ( DOI 10.1099/00207713-34-1-5 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66793	Mukherjee et al.: GEBA: 1,003 reference genomes of bacterial and archaeal isolates expand coverage of the tree of life. 35: 676 - 683 2017 ( DOI 10.1038/nbt.3886 , PubMed 28604660 )
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Hydrogenobacter thermophilus (DSM 6534, IAM 12695, TK-6)

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