Name: Proteus mirabilis DSM 4479
Creator: BacDive
License: http://creativecommons.org/licenses/by-nc/4.0/

Strain identifier

BacDive ID: 5058

Type strain:

Species: Proteus mirabilis

Culture col. no.: DSM 4479, ATCC 29906, CIP 103181, NCTC 11938, WDCM 00023, CDC PR 14, JCM 1669, CCUG 26767, CECT 4168, KCTC 2566, LMG 3257, NBRC 105697

Strain history: R. Sakazaki 4030 <-- ATCC 29906 <-- CDC PR14.

NCBI tax ID(s): 525369 (strain), 584 (species)

Other strains from Proteus mirabilis

Section

Proteus mirabilis DSM 4479 is a mesophilic human pathogen that has multiple antibiotic resistances.

antibiotic resistance
human pathogen
mesophilic
16S sequence
Bacteria
genome sequence

Information on the name and the taxonomic classification. Name and taxonomic classification

	Last LPSN update	25-08-2022 (DD-MM-YYYY)
	Domain	Bacteria
	Phylum	Pseudomonadota
	Class	Gammaproteobacteria
	Order	Enterobacterales
	Family	Morganellaceae
	Genus	Proteus
	Species	Proteus mirabilis
	Full Scientific Name (PNU)	Proteus mirabilis Hauser 1885 (Approved Lists 1980)

Information on culture and growth conditions Culture and growth conditions

[Ref.: #1692]

Culture medium

COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)

[Ref.: #1692]

Culture medium growth

[Ref.: #1692]

Culture medium link

Medium recipe at MediaDive

[Ref.: #1692]

Culture medium composition

expand / minimize

[Ref.: #1692]

Culture medium

NUTRIENT AGAR (DSMZ Medium 1)

[Ref.: #1692]

Culture medium growth

[Ref.: #1692]

Culture medium link

Medium recipe at MediaDive

[Ref.: #1692]

Culture medium composition

expand / minimize

[Ref.: #37129]

Culture medium

MEDIUM 72- for trypto casein soja agar

[Ref.: #37129]

Culture medium growth

[Ref.: #37129]

Culture medium composition

expand / minimize

[Ref.: #1692]

Culture medium

TRYPTICASE SOY YEAST EXTRACT MEDIUM (DSMZ Medium 92)

[Ref.: #1692]

Culture medium growth

[Ref.: #1692]

Culture medium link

Medium recipe at MediaDive

[Ref.: #1692]

Culture medium composition

expand / minimize

		Temperature
[Ref.: #1692]	growth	37 °C
[Ref.: #37129]	growth	30 °C
[Ref.: #67770]	growth	37 °C

[Ref.: #1692]	Temperature range	mesophilic
[Ref.: #37129]	Temperature range	mesophilic
[Ref.: #67770]	Temperature range	mesophilic

Information on physiology and metabolism Physiology and metabolism

Note that the displayed test results represent raw data and therefore may deviate!

Antibiotic susceptibility testing

Test 1

Test 2

Test 3

Test 4

Reference

[Ref.: #1692]
Mueller-Hinton Agar
37
1
aerob
yes
Inhibition zone diameter in mm
26
resistant0
30
36-38
32
30
26
44
42-44
32
12
20
20-22
22
resistant0
resistant0
resistant0
36-38
40
resistant0
resistant0
8
resistant0
resistant0
22
20-22
6
42
resistant0
36-38
32
10-12
resistant0
resistant0
10
34

[Ref.: #1692]
Mueller-Hinton Agar
37
1
aerob
yes
Inhibition zone diameter in mm
22
resistant0
28-30
38
30
28-30
34-36
42
42-44
32
8
22
22
22-24
resistant0
resistant0
resistant0
38
40
resistant0
26
8
resistant0
resistant0
24
20-22
6
42
6
38-40
32
8
resistant0
resistant0
resistant0
30-32

[Ref.: #1692]
Mueller-Hinton Agar



yes
Inhibition zone diameter in mm
22
resistant0
28-30
38
32
30
28
44
46
32-34
8
20-22
22-24
24
resistant0
resistant0
resistant0
36-38
40
resistant0
26
10
resistant0
resistant0
34
20
resistant0
46
resistant0
40
32
resistant0
resistant0
resistant0
resistant0
34

[Ref.: #1692]
Mueller Hinton
30

aerob
yes
Inhibition zone diameter in mm
20
resistant0
28
38
32
30
26-28
46
48
34
6
24
22
24
resistant0
resistant0
resistant0
40
42
resistant0
28
10
resistant0
6
26
20
6
46
resistant0
34
30-32
6
10
resistant0
resistant0
34

Only first 15 entries are displayed. Click here to see all.

[Ref.: #1692]

Name of produced compound

volatile organic compounds

	Metabolite	Utilization activity	Kind of utilization tested
[Ref.: #68368]	amygdalin ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	arginine ChEBI	-	hydrolysis	* from API 20E
[Ref.: #68368]	citrate ChEBI	+	assimilation	* from API 20E
[Ref.: #68368]	D-glucose ChEBI	+	fermentation	* from API 20E
[Ref.: #68368]	D-mannitol ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	gelatin ChEBI	+	hydrolysis	* from API 20E
[Ref.: #68368]	L-arabinose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	L-rhamnose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	lysine ChEBI	-	degradation	* from API 20E
[Ref.: #68368]	melibiose ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	myo-inositol ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	ornithine ChEBI	+	degradation	* from API 20E
[Ref.: #68368]	sorbitol ChEBI	-	fermentation	* from API 20E
[Ref.: #68368]	urea ChEBI	+	hydrolysis	* from API 20E
	Only first 10 entries are displayed. Click here to see all.

	Metabolite production	Metabolite
[Ref.: #68368]		acetoin ChEBI	* from API 20E
[Ref.: #68368]		hydrogen sulfide ChEBI	* from API 20E

	Physiological tests	Metabolite	Voges-Proskauer-test
[Ref.: #68368]		acetoin ChEBI	-	* from API 20E

	Enzyme	Enzyme activity	EC number
[Ref.: #68368]	arginine dihydrolase	-	3.5.3.6	* from API 20E
[Ref.: #68368]	beta-galactosidase	-	3.2.1.23	* from API 20E
[Ref.: #68368]	cytochrome oxidase	-	1.9.3.1	* from API 20E
[Ref.: #68368]	gelatinase	+		* from API 20E
[Ref.: #68368]	lysine decarboxylase	-	4.1.1.18	* from API 20E
[Ref.: #68368]	ornithine decarboxylase	+	4.1.1.17	* from API 20E
[Ref.: #68368]	tryptophan deaminase	+	4.1.99.1	* from API 20E
[Ref.: #68368]	urease	+	3.5.1.5	* from API 20E

API® 20E:

Note that the displayed test results represent raw data and therefore may deviate!

	API ID	beta-GalactosidaseONPG	Arginine dihydrolaseADH (Arg)	Lysine decarboxylaseLDC (Lys)	Ornithine decarboxylaseODC	Citrate utilizationCIT	H2S productionH2S	Urease/urea hydrolysisURE	Tryptophan deaminaseTDA (Trp)	Indole productionIND	Acetoin production (Voges Proskauer test)VP	Gelatinase/gelatin hydrolysisGEL	Fermentation/oxidation of D-glucoseGLU	Fermentation/oxidation of D-mannitolMAN	Fermentation/oxidation of inositolINO	Fermentation/oxidation of sorbitolSor	Fermentation/oxidation of L-rhamnoseRHA	Fermentation/oxidation of sucroseSAC	Fermentation/oxidation of melibioseMEL	Fermentation/oxidation of amygdalinAMY	Fermentation/oxidation of L-arabinoseARA	Cytochrome oxidaseOX	Nitrite productionNO2	Reduction to N2N2	MotilityMOB	Growth on MacConkey mediumMAC	Oxidative catabolisation of D-glucoseOF-O	Fermentation of D-glucoseOF-F
[Ref.: #1692]	11954	-	-	-	+	+	+	+	+	+/-	-	+	+	-	-	-	-	-	-	-	-	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.
[Ref.: #1692]	12202	-	-	-	+	+	+	+	+	-	-	+	+	-	-	-	-	+/-	-	-	-	-	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.	not determinedn.d.

Information on possible application of the strain and its possible interaction with e.g. potential hosts Safety information

[Ref.: #1692]	Pathogenicity (human)	yes
[Ref.: #1692]	Pathogenicity (animal)	yes
[Ref.: #1692]	Biosafety level	2	Risk group (German classification) According to TRBA 466

Information on genomic background e.g. entries in nucleic sequence databass Sequence information

16S Sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Sequence length (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #20218]	Proteus mirabilis strain ATCC 29906 16S ribosomal RNA gene, partial sequence	AF008582	1497	ENA	584 tax ID	*
[Ref.: #20218]	Proteus mirabilis 16S rRNA gene, strain CIP103181T	AJ301682	1503	ENA	584 tax ID	*
[Ref.: #20218]	Proteus vulgaris 16S rRNA gene, strain CIP103181T	AJ301683	1505	ENA	585 tax ID	*
[Ref.: #20218]	Proteus mirabilis gene for 16S rRNA, partial sequence, strain: JCM 1669	AB626123	1465	ENA	584 tax ID	*
[Ref.: #1692]	Proteus mirabilis strain NCTC 11938 16S ribosomal RNA gene, partial sequence	DQ885256	1503	ENA	584 tax ID
[Ref.: #67770]	Proteus mirabilis gene for 16S ribosomal RNA, partial sequence, strain: JCM 1669	LC060912	1484	ENA	584 tax ID

Genome sequence information:

Only first 5 entries are displayed. Click here to see all.

	Sequence accession description	Seq. accession number	Assembly level (bp)	Sequence database	Associated NCBI tax ID
[Ref.: #66792]	Proteus mirabilis ATCC 29906 ATCC 29906	GCA_000160755	scaffold	GenBank	525369 tax ID	*
[Ref.: #66792]	Proteus mirabilis NCTC11938	GCA_900455245	contig	GenBank	584 tax ID	*
[Ref.: #66792]	Proteus mirabilis ATCC 29906	525369.4	wgs	PATRIC	525369 tax ID	*
[Ref.: #66792]	Proteus mirabilis strain NCTC11938	584.639	wgs	PATRIC	584 tax ID	*
[Ref.: #66792]	Proteus mirabilis ATCC 29906	643886024	draft	JGI IMG/M	525369 tax ID	*
[Ref.: #67770]	Proteus mirabilis ATCC 29906, whole genome shotgun sequencing project	ACLE00000000		GenBank	525369 tax ID

Availability in culture collections External links

[Ref.: #1692]

Culture collection no.

DSM 4479, ATCC 29906, CIP 103181, NCTC 11938, WDCM 00023, CDC PR 14, JCM 1669, CCUG 26767, CECT 4168, KCTC 2566, LMG 3257, NBRC 105697

[Ref.: #20218]

Associated Passport(s) in StrainInfo

153957, 16409, 866304

Literature:

Only first 10 entries are displayed. Click here to see all.

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Imipenem resistance in clinical isolates of Proteus mirabilis associated with alterations in penicillin-binding proteins.	Neuwirth C, Siebor E, Duez JM, Pechinot A, Kazmierczak A	J Antimicrob Chemother	10.1093/jac/36.2.335	1995	*
Genetics	DNA gyrase and topoisomerase IV mutations associated with fluoroquinolone resistance in Proteus mirabilis.	Weigel LM, Anderson GJ, Tenover FC	Antimicrob Agents Chemother	10.1128/AAC.46.8.2582-2587.2002	2002	*
Enzymology	Integration of a transposon Tn1-encoded inhibitor-resistant beta-lactamase gene, bla(TEM-67) from Proteus mirabilis, into the Escherichia coli chromosome.	Naas T, Zerbib M, Girlich D, Nordmann P	Antimicrob Agents Chemother	10.1128/AAC.47.1.19-26.2003	2003	*
Metabolism	Enhanced microbial biomass assay using mutant luciferase resistant to benzalkonium chloride.	Hattori N, Sakakibara T, Kajiyama N, Igarashi T, Maeda M, Murakami S	Anal Biochem	10.1016/s0003-2697(03)00322-1	2003	*
Genetics	Chromosomally encoded blaCMY-2 located on a novel SXT/R391-related integrating conjugative element in a Proteus mirabilis clinical isolate.	Harada S, Ishii Y, Saga T, Tateda K, Yamaguchi K	Antimicrob Agents Chemother	10.1128/AAC.00111-10	2010	*
Enzymology	Expression and characterization of a second L-amino acid deaminase isolated from Proteus mirabilis in Escherichia coli.	Baek JO, Seo JW, Kwon O, Seong SI, Kim IH, Kim CH	J Basic Microbiol	10.1002/jobm.201000086	2011	*
Pathogenicity	Convenient syntheses of cyanuric chloride-derived NHC ligands, their Ag(I) and Au(I) complexes and antimicrobial activity.	Almalioti F, MacDougall J, Hughes S, Hasson MM, Jenkins RL, Ward BD, Tizzard GJ, Coles SJ, Williams DW, Bamford S, Fallis IA, Dervisi A	Dalton Trans	10.1039/c3dt51400e	2013	*
Metabolism	Production of phenylpyruvic acid from L-phenylalanine using an L-amino acid deaminase from Proteus mirabilis: comparison of enzymatic and whole-cell biotransformation approaches.	Hou Y, Hossain GS, Li J, Shin HD, Liu L, Du G	Appl Microbiol Biotechnol	10.1007/s00253-015-6757-0	2015	*
Metabolism	Combination of phenylpyruvic acid (PPA) pathway engineering and molecular engineering of L-amino acid deaminase improves PPA production with an Escherichia coli whole-cell biocatalyst.	Hou Y, Hossain GS, Li J, Shin HD, Du G, Liu L	Appl Microbiol Biotechnol	10.1007/s00253-015-7048-5	2015	*
Enzymology	qnrA6 genetic environment and quinolone resistance conferred on Proteus mirabilis.	Jayol A, Janvier F, Guillard T, Chau F, Merens A, Robert J, Fantin B, Bercot B, Cambau E	J Antimicrob Chemother	10.1093/jac/dkv431	2016	*
Phylogeny	Proteus alimentorum sp. nov., isolated from pork and lobster in Ma'anshan city, China.	Dai H, Wang Y, Fang Y, Huang Z, Kan B, Wang D	Int J Syst Evol Microbiol	10.1099/ijsem.0.002689	2018	*
Pathogenicity	The impact of ethanol extract of propolis on biofilm forming by Proteus Mirabilis strains isolated from chronic wounds infections.	Kwiecinska-Pirog J, Skowron K, Sniegowska A, Przekwas J, Balcerek M, Zaluski D, Gospodarek-Komkowska E	Nat Prod Res	10.1080/14786419.2018.1470513	2018	*
Pathogenicity	Analysis of inflammatory cytokine expression in the urinary tract of BALB/c mice infected with Proteus (P.) mirabilis and enteroaggregative Escherichia (E.) coli (EAEC) strains.	Melendez-Avalos A, Sainz-Espunes T, Castrillon-Rivera LE, Mendoza-Perez F, Palma-Ramos A, Castaneda-Sanchez JI, Drago-Serrano EM	Folia Microbiol (Praha)	10.1007/s12223-019-00714-2	2019	*
	Characterization of a Novel Diarrheagenic Strain of Proteus mirabilis Associated With Food Poisoning in China.	Gong Z, Shi X, Bai F, He X, Zhang H, Li Y, Wan Y, Lin Y, Qiu Y, Chen Q, Hu Q, Cao H	Front Microbiol	10.3389/fmicb.2019.02810	2019	*

References

#1692

Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 4479

#20215

Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )

#20218

Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )

#37129 ; Curators of the CIP;

#66792

Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .

#67770 Japan Collection of Microorganism (JCM) ; Curators of the JCM;

#68368

Automatically annotated from API 20E .

* These data were automatically processed and therefore are not curated

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