Corynebacterium resistens (DSM 45100, CCUG 50093, JCM 12819)

Cell morphology

Multimedia

• @ref:	12342
  multimedia content:	DSM_45100.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_45100.jpg
  caption:	Medium 693 37°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
12342	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)		Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
12342	TRYPTICASE SOY BROTH AGAR+BLOOD (DSMZ Medium 535a)		Medium recipe at MediaDive	Name: TRYPTICASE SOY BROTH AGAR+BLOOD (DSMZ Medium 535a) Composition: None 50.0 g/l Trypticase soy broth 30.0 g/l Agar 15.0 g/l Distilled water

Culture temp

Oxygen tolerance

Spore formation

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	acetate fermentation	100	4 of 4
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	palmitate biosynthesis	100	22 of 22
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	butanoate fermentation	100	4 of 4
66794	coenzyme A metabolism	100	4 of 4
66794	formaldehyde oxidation	100	3 of 3
66794	ppGpp biosynthesis	100	4 of 4
66794	suberin monomers biosynthesis	100	2 of 2
66794	adipate degradation	100	2 of 2
66794	acetoin degradation	100	3 of 3
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	ceramide biosynthesis	100	1 of 1
66794	folate polyglutamylation	100	1 of 1
66794	phenylalanine metabolism	92.31	12 of 13
66794	threonine metabolism	90	9 of 10
66794	starch degradation	90	9 of 10
66794	valine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	isoleucine metabolism	87.5	7 of 8
66794	propanol degradation	85.71	6 of 7
66794	citric acid cycle	85.71	12 of 14
66794	glutamate and glutamine metabolism	82.14	23 of 28
66794	pentose phosphate pathway	81.82	9 of 11
66794	vitamin K metabolism	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	phenylacetate degradation (aerobic)	80	4 of 5
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	heme metabolism	78.57	11 of 14
66794	CO2 fixation in Crenarchaeota	77.78	7 of 9
66794	serine metabolism	77.78	7 of 9
66794	vitamin B1 metabolism	76.92	10 of 13
66794	alanine metabolism	75.86	22 of 29
66794	purine metabolism	75.53	71 of 94
66794	biotin biosynthesis	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	flavin biosynthesis	73.33	11 of 15
66794	metabolism of disaccharids	72.73	8 of 11
66794	proline metabolism	72.73	8 of 11
66794	NAD metabolism	72.22	13 of 18
66794	glycolysis	70.59	12 of 17
66794	propionate fermentation	70	7 of 10
66794	leucine metabolism	69.23	9 of 13
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	histidine metabolism	65.52	19 of 29
66794	isoprenoid biosynthesis	65.38	17 of 26
66794	tetrahydrofolate metabolism	64.29	9 of 14
66794	ketogluconate metabolism	62.5	5 of 8
66794	dTDPLrhamnose biosynthesis	62.5	5 of 8
66794	gluconeogenesis	62.5	5 of 8
66794	C4 and CAM-carbon fixation	62.5	5 of 8
66794	pyrimidine metabolism	62.22	28 of 45
66794	methylglyoxal degradation	60	3 of 5
66794	lipid metabolism	58.06	18 of 31
66794	non-pathway related	57.89	22 of 38
66794	methionine metabolism	57.69	15 of 26
66794	d-mannose degradation	55.56	5 of 9
66794	cysteine metabolism	55.56	10 of 18
66794	tryptophan metabolism	55.26	21 of 38
66794	oxidative phosphorylation	54.95	50 of 91
66794	arginine metabolism	54.17	13 of 24
66794	sulfate reduction	53.85	7 of 13
66794	lysine metabolism	52.38	22 of 42
66794	ethanol fermentation	50	1 of 2
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	glycine metabolism	50	5 of 10
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	glutathione metabolism	50	7 of 14
66794	phenylmercury acetate degradation	50	1 of 2
66794	urea cycle	46.15	6 of 13
66794	daunorubicin biosynthesis	44.44	4 of 9
66794	lipid A biosynthesis	44.44	4 of 9
66794	molybdenum cofactor biosynthesis	44.44	4 of 9
66794	reductive acetyl coenzyme A pathway	42.86	3 of 7
66794	tyrosine metabolism	42.86	6 of 14
66794	ubiquinone biosynthesis	42.86	3 of 7
66794	cardiolipin biosynthesis	42.86	3 of 7
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	carotenoid biosynthesis	40.91	9 of 22
66794	cellulose degradation	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	glycogen metabolism	40	2 of 5
66794	glycine betaine biosynthesis	40	2 of 5
66794	metabolism of amino sugars and derivatives	40	2 of 5
66794	lipoate biosynthesis	40	2 of 5
66794	androgen and estrogen metabolism	37.5	6 of 16
66794	vitamin B6 metabolism	36.36	4 of 11
66794	degradation of hexoses	33.33	6 of 18
66794	nitrate assimilation	33.33	3 of 9
66794	cyanate degradation	33.33	1 of 3
66794	methane metabolism	33.33	1 of 3
66794	sphingosine metabolism	33.33	2 of 6
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	pantothenate biosynthesis	33.33	2 of 6
66794	octane oxidation	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	Entner Doudoroff pathway	30	3 of 10
66794	coenzyme M biosynthesis	30	3 of 10
66794	bile acid biosynthesis, neutral pathway	29.41	5 of 17
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	ascorbate metabolism	27.27	6 of 22
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	degradation of sugar alcohols	25	4 of 16
66794	carnitine metabolism	25	2 of 8
66794	lactate fermentation	25	1 of 4
66794	CMP-KDO biosynthesis	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	degradation of pentoses	25	7 of 28
66794	4-hydroxymandelate degradation	22.22	2 of 9
66794	polyamine pathway	21.74	5 of 23

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence AB128981 (>99% sequence identity) for Corynebacterium resistens from Microbeatlas

Aquatic Samples	29
Soil Samples	32
Animal Samples	935
Plant Samples
Total Samples	996

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM17753v2 assembly for Corynebacterium resistens DSM 45100	complete	GCA_000177535	662755.4	650716029	662755	98.31

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
12342	Corynebacterium resistens gene for 16S rRNA, partial sequence, strain: GTC2026(TYPE STRAIN)	AB128981	1418		662755

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Draft Genome Sequence of a Mycobacterium Strain Isolated from a Clinical Wound Sample.	Ransom EM, Sawhney SS, Dantas G, Burnham CD, Fishbein SRS.	Microbiol Resour Announc	10.1128/mra.00170-22	2022
Genetics	Species- and strain-level diversity of Corynebacteria isolated from human facial skin.	Jensen MG, Svraka L, Baez E, Lund M, Poehlein A, Bruggemann H.	BMC Microbiol	10.1186/s12866-023-03129-9	2023
	Complete Genome Sequence of the Type Strain Corynebacterium mustelae DSM 45274, Isolated from Various Tissues of a Male Ferret with Lethal Sepsis.	Ruckert C, Eimer J, Winkler A, Tauch A.	Genome Announc	10.1128/genomea.01012-15	2015
Genetics	Comparative Analysis of the IclR-Family of Bacterial Transcription Factors and Their DNA-Binding Motifs: Structure, Positioning, Co-Evolution, Regulon Content.	Suvorova IA, Gelfand MS.	Front Microbiol	10.3389/fmicb.2021.675815	2021
Pathogenicity	Dissemination of antibiotic resistance genes from antibiotic producers to pathogens.	Jiang X, Ellabaan MMH, Charusanti P, Munck C, Blin K, Tong Y, Weber T, Sommer MOA, Lee SY.	Nat Commun	10.1038/ncomms15784	2017
	Characterization and antimicrobial susceptibility of one antibiotic-sensitive and one multidrug-resistant Corynebacterium kroppenstedtii strain isolated from patients with granulomatous mastitis.	Fernandez-Natal I, Rodriguez-Lazaro D, Marrodan-Ciordia T, Saez-Nieto JA, Valdezate S, Rodriguez-Pollan H, Tauch A, Soriano F.	New Microbes New Infect	10.1016/j.nmni.2016.09.006	2016
	Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium.	Dover LG, Thompson AR, Sutcliffe IC, Sangal V.	Front Microbiol	10.3389/fmicb.2021.802532	2021
Genetics	Unravelling the antibiotic and heavy metal resistome of a chronically polluted soil.	Salam LB.	3 Biotech	10.1007/s13205-020-02219-z	2020
Enzymology	Rhodococcus sp. strain CR-53 LipR, the first member of a new bacterial lipase family (family X) displaying an unusual Y-type oxyanion hole, similar to the Candida antarctica lipase clan.	Bassegoda A, Pastor FI, Diaz P.	Appl Environ Microbiol	10.1128/aem.06332-11	2012
Enzymology	Quantification of Propionibacterium acidipropionici P169 bacteria in environmental samples by use of strain-specific primers derived by suppressive subtractive hybridization.	Peng M, Smith AH, Rehberger TG.	Appl Environ Microbiol	10.1128/aem.02586-10	2011
Genetics	Protein domain architectures provide a fast, efficient and scalable alternative to sequence-based methods for comparative functional genomics.	Koehorst JJ, Saccenti E, Schaap PJ, Martins Dos Santos VAP, Suarez-Diez M.	F1000Res	10.12688/f1000research.9416.3	2016
Metabolism	Two-component signal transduction in Corynebacterium glutamicum and other corynebacteria: on the way towards stimuli and targets.	Bott M, Brocker M.	Appl Microbiol Biotechnol	10.1007/s00253-012-4060-x	2012
	Microbial Diversity and Resistome in Milk of Cows with Subclinical Mastitis in a Coastal District of Odisha, India.	Sahoo S, Behera MR, Mishra B, Kar S, Sahoo P, Sahoo N, Biswal S.	Indian J Microbiol	10.1007/s12088-024-01198-6	2024
	The Brief Case: A case of bloodstream infection with Corynebacterium kroppenstedtii in an infant.	Giffen SR, Alby K.	J Clin Microbiol	10.1128/jcm.00820-23	2024
	mNGS-based dynamic pathogen monitoring for accurate diagnosis and treatment of severe pneumonia caused by fungal infections.	Li Z, Wu C, Tang LA, Liang Y, A R, Huang D, Ning C, Wang W, Tan W.	Biosaf Health	10.1016/j.bsheal.2023.04.004	2023
	Emerging Insights into Corynebacterium Kroppenstedtii Complex Associated Breast Abscesses: A Retrospective Study.	Sasi S, Hamed MMM, Abdel Hadi HEA, Goravey W, Ibrahim E, Abid FB, Doiphode S, Wilson G, Kashaf ASA, Al-Maslamani M, Al-Khal A.	Infect Drug Resist	10.2147/idr.s501554	2025
	Tropical leg lymphedema caused by podoconiosis is associated with increased colonisation by anaerobic bacteria.	Neidhofer C, Nkwetta DL, Fuen BR, Yenban NF, Mbiatong N, Nchanji GT, Korir P, Wetzig N, Sieber M, Thiele R, Parcina M, Klarmann-Schulz U, Hoerauf A, Wanji S, Ritter M.	Sci Rep	10.1038/s41598-023-40765-7	2023
Phylogeny	Contribution of the Mobilome to the Configuration of the Resistome of Corynebacterium striatum.	Urrutia C, Leyton-Carcaman B, Abanto Marin M.	Int J Mol Sci	10.3390/ijms251910499	2024
	Multi-omics analysis reveals the interplay between pulmonary microbiome and host in immunocompromised patients with sepsis-induced acute lung injury.	Lu F, Huang T, Chen R, Yin H.	Microbiol Spectr	10.1128/spectrum.01424-24	2024
Metabolism	Identification and characterization of the channel-forming protein in the cell wall of Corynebacterium amycolatum.	Soltan Mohammadi N, Mafakheri S, Abdali N, Barcena-Uribarri I, Tauch A, Benz R.	Biochim Biophys Acta	10.1016/j.bbamem.2013.06.024	2013
Metabolism	novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.	Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T.	Antimicrob Agents Chemother	10.1128/aac.01105-12	2013
Enzymology	AAC(3)-XI, a new aminoglycoside 3-N-acetyltransferase from Corynebacterium striatum.	Galimand M, Fishovitz J, Lambert T, Barbe V, Zajicek J, Mobashery S, Courvalin P.	Antimicrob Agents Chemother	10.1128/aac.01203-15	2015
	Analysis of the pathogenic potential of nosocomial Pseudomonas putida strains.	Fernandez M, Porcel M, de la Torre J, Molina-Henares MA, Daddaoua A, Llamas MA, Roca A, Carriel V, Garzon I, Ramos JL, Alaminos M, Duque E.	Front Microbiol	10.3389/fmicb.2015.00871	2015
Metabolism	Urocanate as a potential signaling molecule for bacterial recognition of eukaryotic hosts.	Zhang XX, Ritchie SR, Rainey PB.	Cell Mol Life Sci	10.1007/s00018-013-1527-6	2014
Enzymology	Antibiotic resistance determinants in a Pseudomonas putida strain isolated from a hospital.	Molina L, Udaondo Z, Duque E, Fernandez M, Molina-Santiago C, Roca A, Porcel M, de la Torre J, Segura A, Plesiat P, Jeannot K, Ramos JL.	PLoS One	10.1371/journal.pone.0081604	2014
	Pediatric fecal microbiota harbor diverse and novel antibiotic resistance genes.	Moore AM, Patel S, Forsberg KJ, Wang B, Bentley G, Razia Y, Qin X, Tarr PI, Dantas G.	PLoS One	10.1371/journal.pone.0078822	2013
Enzymology	Genotypic differences between strains of the opportunistic pathogen Corynebacterium bovis isolated from humans, cows, and rodents.	Cheleuitte-Nieves C, Gulvik CA, McQuiston JR, Humrighouse BW, Bell ME, Villarma A, Fischetti VA, Westblade LF, Lipman NS.	PLoS One	10.1371/journal.pone.0209231	2018
	Identification of new genes contributing to the extreme radioresistance of Deinococcus radiodurans using a Tn5-based transposon mutant library.	Dulermo R, Onodera T, Coste G, Passot F, Dutertre M, Porteron M, Confalonieri F, Sommer S, Pasternak C.	PLoS One	10.1371/journal.pone.0124358	2015
Genetics	Comparative genomics reveals distinct host-interacting traits of three major human-associated propionibacteria.	Mak TN, Schmid M, Brzuszkiewicz E, Zeng G, Meyer R, Sfanos KS, Brinkmann V, Meyer TF, Bruggemann H.	BMC Genomics	10.1186/1471-2164-14-640	2013
	The pan-genome of the animal pathogen Corynebacterium pseudotuberculosis reveals differences in genome plasticity between the biovar ovis and equi strains.	Soares SC, Silva A, Trost E, Blom J, Ramos R, Carneiro A, Ali A, Santos AR, Pinto AC, Diniz C, Barbosa EG, Dorella FA, Aburjaile F, Rocha FS, Nascimento KK, Guimaraes LC, Almeida S, Hassan SS, Bakhtiar SM, Pereira UP, Abreu VA, Schneider MP, Miyoshi A, Tauch A, Azevedo V.	PLoS One	10.1371/journal.pone.0053818	2013
Genetics	Genome-Based Taxonomic Classification of the Phylum Actinobacteria.	Nouioui I, Carro L, Garcia-Lopez M, Meier-Kolthoff JP, Woyke T, Kyrpides NC, Pukall R, Klenk HP, Goodfellow M, Goker M.	Front Microbiol	10.3389/fmicb.2018.02007	2018
Genetics	Complete Genome Sequence of the Type Strain Corynebacterium epidermidicanis DSM 45586, Isolated from the Skin of a Dog Suffering from Pruritus.	Ruckert C, Eimer J, Winkler A, Tauch A	Genome Announc	10.1128/genomeA.00959-15	2015
Genetics	Draft Genome Sequences of Corynebacterium kroppenstedtii CNM633/14 and CNM632/14, Multidrug-Resistant and Antibiotic-Sensitive Isolates from Nodules of Granulomatous Mastitis Patients.	Fernandez-Natal MI, Soriano F, Ariza-Miguel J, Marrodan-Ciordia T, Acedo A, Hernandez M, Tauch A, Rodriguez-Lazaro D	Genome Announc	10.1128/genomeA.00525-15	2015
Genetics	Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.	Schroder J, Maus I, Meyer K, Wordemann S, Blom J, Jaenicke S, Schneider J, Trost E, Tauch A	BMC Genomics	10.1186/1471-2164-13-141	2012
Metabolism	Binding of the IclR-type regulator HutR in the histidine utilization (hut) gene cluster of the human pathogen Corynebacterium resistens DSM 45100.	Schroder J, Maus I, Ostermann AL, Kogler AC, Tauch A	FEMS Microbiol Lett	10.1111/j.1574-6968.2012.02564.x	2012
Genetics	Genome sequence and description of Corynebacterium ihumii sp. nov.	Padmanabhan R, Dubourg G, Lagier JC, Couderc C, Michelle C, Raoult D, Fournier PE.	Stand Genomic Sci	10.4056/sigs.5149006	2014
Phylogeny	Corynebacterium zhongnanshanii sp. nov. isolated from trachea of Marmota himalayana, Corynebacterium lujinxingii sp. nov. and Corynebacterium wankanglinii sp. nov. from human faeces.	Zhang G, Yang J, Lai XH, Jin D, Lu S, Ren Z, Qin T, Pu J, Ge Y, Cheng Y, Yang C, Lv X, Jiao Y, Huang Y, Xu J	Int J Syst Evol Microbiol	10.1099/ijsem.0.005069	2021
Phylogeny	Corynebacterium resistens sp. nov., a new multidrug-resistant coryneform bacterium isolated from human infections.	Otsuka Y, Kawamura Y, Koyama T, Iihara H, Ohkusu K, Ezaki T	J Clin Microbiol	10.1128/JCM.43.8.3713-3717.2005	2005