Corynebacterium lipophiloflavum (DSM 44291, CCUG 37336, DMMZ 1944)

Name: Corynebacterium lipophiloflavum (DSM 44291, CCUG 37336, DMMZ 1944)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 3174

Type strain

Culture col. no. DSM 44291 CCUG 37336 DMMZ 1944 LMG 19051 CIP 105127 3 more

NCBI tax ID(s) 525263 161889

Special Collections DSMZ CCUG JCM CIP Wink compendium

History <- G. Funke, DMMZ <- W.R. Heizmann CCUG 37336 <-- G. Funke DMMZ 1944 <-- W. R. Heizmann. CIP <- 1997, G. Funke, Zürich Univ., Zürich, Switzerland: strain DMMZ 1944 <- W.R. Heizmann

Links

Corynebacterium lipophiloflavum DSM 44291 is an aerobe, mesophilic, Gram-positive prokaryote that was isolated from vaginal swab.

Gram-positive rod-shaped aerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 14084

LMG 19051,CCUG 37336,DSM 44291,ATCC 700352,CIP 105127,CCM 4677,JCM 10383

@ref 20215

Last LPSN update 2025-12-16 09:47:29

Domain Bacillati

Phylum Actinomycetota

Class Actinomycetes

Order Mycobacteriales

Family Corynebacteriaceae

Genus Corynebacterium

Species Corynebacterium lipophiloflavum

Full scientific name Corynebacterium lipophiloflavum Funke et al. 1997

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Confidence
120622	positive	rod-shaped
125438			91.5
125438	positive		92.527
125439	positive		95.1

Colony morphology

@ref	Colony color	Incubation period	Medium used
19647		10-14 days	ISP 2
19647		10-14 days	ISP 3
19647	Beige	10-14 days	ISP 4
19647		10-14 days	ISP 5
19647		10-14 days	ISP 6
19647		10-14 days	ISP 7
120622

Multicellular morphology

@ref	Forms multicellular complex	Medium name
19647		ISP 2
19647		ISP 3
19647		ISP 4
19647		ISP 5
19647		ISP 6
19647		ISP 7

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
11648	COLUMBIA BLOOD MEDIUM (DSMZ Medium 693)	Medium recipe at MediaDive	Name: COLUMBIA BLOOD MEDIUM (DSMZ Medium 693) Composition: Defibrinated sheep blood 50.0 g/l Columbia agar base
11648	TRYPTICASE SOY BROTH AGAR+BLOOD (DSMZ Medium 535a)	Medium recipe at MediaDive	Name: TRYPTICASE SOY BROTH AGAR+BLOOD (DSMZ Medium 535a) Composition: None 50.0 g/l Trypticase soy broth 30.0 g/l Agar 15.0 g/l Distilled water
19647	ISP 2		Name: ISP 2 / Yeast Malt Agar (5265); 5265 Composition Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l Agar 15.0 g/l Preparation: Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.0 Usage: Maintenance and Taxonomy Organisms: All Actinomycetes
19647	ISP 3		Name: ISP 3; 5315 Composition Dog oat flakes 20.0 g/l Trace element solution (5314) 2.5 ml/l Agar 18.0 g/l Preparation: Oat flakes are cooked for 20 minutes, trace element solution and agar are added (in the case of non rolled oat flakes the suspension has to bee filtrated). Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.8 Usage: Maintenance and taxonomy (e.g. SEM As liquid medium for metabolite production) Organisms: All Actinomycetes Trace element solution 5314 Name: Trace element solution 5314; 5314 Composition CaCl2 x H2O 3.0 g/l Fe-III-citrate 1.0 g/l MnSO4 0.2 g/l ZnCl2 0.1 g/l CuSO4 x 5 H2O 0.025 g/l Sodium tetra borate 0.2 g/l CoCl2 x 6 H2O 0.004 g/l Sodium molybdate 0.01 g/l Preparation: Use double destillated water. Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Trace element solution for different media Organisms:
19647	ISP 4		Name: ISP 4; DSM 547 Solution I: Difco soluble starch, 10.0 g. Make a paste of the starch with a small amount of cold distilled water and bring to a volume of 500 ml. Solution II: CaCO3 2.0 g K2HPO4 (anhydrous) 1.0 g MgSO4 x 7 H2O 1.0 g NaCl 1.0 g (NH4)2SO4 2.0 g Distilled water 500.0 ml Trace salt solution (see below) 1.0 ml The pH should be between 7.0 and 7.4. Do not adjust if it is within this range. Mix solutions I and II together. Add 20.0 g agar. Liquify agar by steaming at 100°C for 10 to 20 min. Trace element solution: FeSO4 x 7 H2O 0.1 g MnCl2 x 4 H2O 0.1 g ZnSO4 x 7 H2O 0.1 g Distilled water 100.0 ml
19647	ISP 5		Name: ISP 5 (5323) Composition L-Asparagine 1.0 g/l Glycerol 10.0 g/l K2HPO4 1.0 g/l Salt solution (see preparation) 1.0 ml/l Agar 20.0 g/l Preparation: Salt solution 1.0 g FeSO4 x 7 H2O 1.0 g MnCl2 x 4 H2O 1.0 g ZNSO4 x 7 H2O in 100 ml water Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.2 Usage: Maintenance and taxonomy Organisms: All Actinomycetes
19647	ISP 6		Name: ISP 6 (5318) Composition Peptone 15.0 g/l Proteose peptose 5.0 g/l Ferric ammonium citrate 0.5 g/l Sodium glycerophosphate 1.0 g/l Sodium thiosulfate 0.08 g/l Yeast extract 1.0 g/l Agar 15.0 g/l Sterilisation: 20 minutes at 121°C pH before sterilisation: Usage: Production of melanoid pigments Organisms: All Actinomycetes
19647	ISP 7		Name: ISP 7 (5322) Composition Glycerol 15.0 g/l L-Tyrosine 0.5 g/l L-Asparagine 1.0 g/l K2HPO4 0.5 g/l NaCl 0.5 g/l FeSO4 x 7 H2O 0.01 g/l Trace element solution 5343 1.0 ml/l Agar 20.0 Sterilisation: 20 minutes at 121°C pH before sterilisation: 7.3 Usage: Production of melanoid pigments Organisms: All Actinomycetes
37203	MEDIUM 6 - Columbia agar with 10 % horse blood		Distilled water make up to (1000.000 ml);Columbia agar (39.000 g);Horseblood (100.000 ml)
120622	CIP Medium 6	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
11648	positive	growth	37	mesophilic
19647	positive	optimum	37	mesophilic
37203	positive	growth	37	mesophilic
53613	positive	growth	30-37	mesophilic
67770	positive	growth	37	mesophilic
120622	positive	growth	25-41
120622	negative	growth	10
120622	negative	growth	15
120622	negative	growth	45

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
53613	aerobe
120622	facultative anaerobe

Halophily

@ref	Salt	Tested relation	Concentration
120622	NaCl	growth	0 %
120622	NaCl	growth	2 %
120622	NaCl	growth	4 %
120622	NaCl	growth	6 %
120622	NaCl	growth	8 %
120622	NaCl	growth	10 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68379	17634 ChEBI	D-glucose	-	fermentation	from API Coryne
68371	17634 ChEBI	D-glucose	-	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68379	16899 ChEBI	D-mannitol	-	fermentation	from API Coryne
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68379	16988 ChEBI	D-ribose	-	fermentation	from API Coryne
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68379	65327 ChEBI	D-xylose	-	fermentation	from API Coryne
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68379	4853 ChEBI	esculin	-	hydrolysis	from API Coryne
120622	4853 ChEBI	esculin	-	hydrolysis
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68379	5291 ChEBI	gelatin	-	hydrolysis	from API Coryne
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68379	28087 ChEBI	glycogen	-	fermentation	from API Coryne
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
120622	606565 ChEBI	hippurate	-	hydrolysis
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68379	17716 ChEBI	lactose	-	fermentation	from API Coryne
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68379	17306 ChEBI	maltose	-	fermentation	from API Coryne
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
68379	17632 ChEBI	nitrate	-	reduction	from API Coryne
120622	17632 ChEBI	nitrate	-	reduction
120622	17632 ChEBI	nitrate	+	respiration
120622	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371		Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68379	17992 ChEBI	sucrose	-	fermentation	from API Coryne
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68379	16199 ChEBI	urea	+	hydrolysis	from API Coryne
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
120622	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Voges-proskauer-test	Methylred-test
120622	15688 ChEBI	acetoin	-
120622	17234 ChEBI	glucose		+

Enzymes

@ref	Value	Activity	Ec
120622	alcohol dehydrogenase	-	1.1.1.1
68379	alkaline phosphatase	-	3.1.3.1	from API Coryne
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68379	alpha-glucosidase	-	3.2.1.20	from API Coryne
68382	alpha-mannosidase	-	3.2.1.24	from API zym
120622	amylase	-
68382	beta-galactosidase	-	3.2.1.23	from API zym
120622	beta-galactosidase	-	3.2.1.23
68379	beta-galactosidase	-	3.2.1.23	from API Coryne
68382	beta-glucosidase	-	3.2.1.21	from API zym
68379	beta-glucosidase	-	3.2.1.21	from API Coryne
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68379	beta-glucuronidase	-	3.2.1.31	from API Coryne
120622	caseinase	-	3.4.21.50
120622	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
120622	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
120622	gamma-glutamyltransferase	-	2.3.2.2
120622	gelatinase	-
68379	gelatinase	-		from API Coryne
120622	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
120622	lipase	-
68382	lipase (C 14)	-		from API zym
120622	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API zym
68379	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API Coryne
120622	ornithine decarboxylase	-	4.1.1.17
120622	oxidase	-
120622	phenylalanine ammonia-lyase	-	4.3.1.24
68379	pyrazinamidase	-	3.5.1.B15	from API Coryne
68379	pyrrolidonyl arylamidase	-	3.4.19.3	from API Coryne
68382	trypsin	-	3.4.21.4	from API zym
120622	tryptophan deaminase	-
120622	tween esterase	-
120622	urease	+	3.5.1.5
68379	urease	+	3.5.1.5	from API Coryne
68382	valine arylamidase	-		from API zym

API coryne

@ref	Reduction of nitrateNIT	PYZ	PYRA	PAL	beta GUR	beta GAL	alpha GLU	beta NAG	ESC	URE	GEL	Control fermentationControl	GLU	RIB	XYL	MAN	MAL	LAC	SAC	GLYG	CAT
19647	-	-	-	-	-	-	-	-	-	+	-	not determinedn.d.	-	-	-	-	-	-	-	-	not determinedn.d.

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
19647	not determinedn.d.	-	+	+	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-
120622	-	+	+	+	-	+	-	-	-	-	+	+	-	-	-	+	-	-	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
120622	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
120622	not determinedn.d.	+	-	+	-	-	-	+	-	+	-	+	+	+	-	-	-	-	+	+	+	-	+	-	-	-	-	-	-	+	-	+	-	-	+	-	-	-	-	-	+	-	+	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	-	-	+	+	-	-	-	-	-	-	-	-	-	-	-	-	+	+	+	-	-	+	-	-	-	-	-	-	-	+	-	-	-	-	+	-	-	-	+	-	-	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Patient	#Swab
#Host Body-Site	#Urogenital tract	#Vagina

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
11648	vaginal swab	Stuttgart	Germany	DEU	Europe
53613	Human vagina,bacterial vaginosis	Zürich	Switzerland	CHE	Europe
67770	Patient with bacterial vaginosis		Germany	DEU	Europe
120622	Human, Vaginosis	Stuttgart	Germany	DEU	Europe

Taxonmaps

69479

Global distribution of 16S sequence Y09045 (>99% sequence identity) for Corynebacterium lipophiloflavum from Microbeatlas

Aquatic Samples	103
Soil Samples	48
Animal Samples	2550
Plant Samples	24
Total Samples	2725

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Biosafety level	Biosafety level comment
11648	yes, in single cases	1	Risk group (German classification) According to TRBA 466
19647		2	Risk group (German classification) According to TRBA 466
120622		2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
67770	ASM15963v1 assembly for Corynebacterium lipophiloflavum DSM 44291	scaffold	GCA_000159635	525263.3	643886002	525263	42.69

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Corynebacterium lipophiloflavum 16S rRNA gene, strain DMMZ 1944; CCUG 37336; DSM 44291	Y09045	1474		161889

GC content

@ref	GC-content (mol%)	Method
67770	65	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Corynebacterium lipophiloflavum DSM 44291
NCBI: GCA_000159635

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	66.70	no
125439	motility	BacteriaNetⓘ	no	80.60	no
125439	gram_stain	BacteriaNetⓘ	positive	95.10	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	89.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Corynebacterium lipophiloflavum DSM 44291
PATRIC: 525263.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	92.53	no
125438	anaerobic	anaerobicⓘ	no	94.46	yes
125438	spore-forming	spore-formingⓘ	no	79.88	no
125438	aerobic	aerobicⓘ	yes	55.50	no
125438	thermophilic	thermophileⓘ	no	93.00	yes
125438	flagellated	motile2+ⓘ	no	91.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Nisin-like biosynthetic gene clusters are widely distributed across microbiomes.	Hourigan D, Field D, Murray E, Sugrue I, O'Connor PM, Hill C, Ross RP.	mBio	10.1128/mbio.01545-25	2025
	Culturomics of the pig tonsil microbiome identifies new species and an untapped source of novel antimicrobials.	de Oliveira IMF, Fredriksen S, Gutierrez MF, Harmsen HJM, Boekhorst J, van Baarlen P, Wells JM.	Microbiome	10.1186/s40168-025-02064-3	2025
	Identification and Characterization of Corynaridin, a Novel Linaridin from Corynebacterium lactis.	Pashou E, Reich SJ, Reiter A, Weixler D, Eikmanns BJ, Oldiges M, Riedel CU, Goldbeck O.	Microbiol Spectr	10.1128/spectrum.01756-22	2023
Genetics	Targeted Large-Scale Genome Mining and Candidate Prioritization for Natural Product Discovery.	Malit JJL, Leung HYC, Qian PY.	Mar Drugs	10.3390/md20060398	2022
Genetics	Mining and Biosynthesis of Bioactive Lanthipeptides From Microorganisms.	Li C, Alam K, Zhao Y, Hao J, Yang Q, Zhang Y, Li R, Li A.	Front Bioeng Biotechnol	10.3389/fbioe.2021.692466	2021
	After a century of nisin research - where are we now?	Field D, Fernandez de Ullivarri M, Ross RP, Hill C.	FEMS Microbiol Rev	10.1093/femsre/fuad023	2023
	Phylogenomic Reappraisal of Fatty Acid Biosynthesis, Mycolic Acid Biosynthesis and Clinical Relevance Among Members of the Genus Corynebacterium.	Dover LG, Thompson AR, Sutcliffe IC, Sangal V.	Front Microbiol	10.3389/fmicb.2021.802532	2021
	Recent Advances in Discovery, Bioengineering, and Bioactivity-Evaluation of Ribosomally Synthesized and Post-translationally Modified Peptides.	Zhong G, Wang ZJ, Yan F, Zhang Y, Huo L.	ACS Bio Med Chem Au	10.1021/acsbiomedchemau.2c00062	2023
Transcriptome	In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.	Marsh AJ, O'Sullivan O, Ross RP, Cotter PD, Hill C.	BMC Genomics	10.1186/1471-2164-11-679	2010
Phylogeny	A primary assessment of the endophytic bacterial community in a xerophilous moss (Grimmia montana) using molecular method and cultivated isolates.	Liu XL, Liu SL, Liu M, Kong BH, Liu L, Li YH.	Braz J Microbiol	10.1590/s1517-83822014000100022	2014
Metabolism	Two-component signal transduction in Corynebacterium glutamicum and other corynebacteria: on the way towards stimuli and targets.	Bott M, Brocker M.	Appl Microbiol Biotechnol	10.1007/s00253-012-4060-x	2012
	Coordinated conformational changes in P450 decarboxylases enable hydrocarbons production from renewable feedstocks.	Generoso WC, Alvarenga AHS, Simoes IT, Miyamoto RY, Melo RR, Guilherme EPX, Mandelli F, Santos CA, Prata R, Santos CRD, Colombari FM, Morais MAB, Pimentel Fernandes R, Persinoti GF, Murakami MT, Zanphorlin LM.	Nat Commun	10.1038/s41467-025-56256-4	2025
	Bacteria, yeasts, and fungi associated with larval food of Brazilian native stingless bees.	Santos ACC, Borges LDF, Rocha NDC, de Carvalho Azevedo VA, Bonetti AM, Dos Santos AR, da Rocha Fernandes G, Dantas RCC, Ueira-Vieira C.	Sci Rep	10.1038/s41598-023-32298-w	2023
Pathogenicity	Dysbiotic Lesional Microbiome With Filaggrin Missense Variants Associate With Atopic Dermatitis in India.	Nath S, Kumari N, Bandyopadhyay D, Sinha N, Majumder PP, Mitra R, Mukherjee S.	Front Cell Infect Microbiol	10.3389/fcimb.2020.570423	2020
	Characterizing Peri-Implant and Sub-Gingival Microbiota through Culturomics. First Isolation of Some Species in the Oral Cavity. A Pilot Study.	Martellacci L, Quaranta G, Fancello G, D'Addona A, Sanguinetti M, Patini R, Masucci L.	Pathogens	10.3390/pathogens9050365	2020
Phylogeny	Role of Williamsia and Segniliparus in human infections with the approach taxonomy, cultivation, and identification methods.	Fatahi-Bafghi M.	Ann Clin Microbiol Antimicrob	10.1186/s12941-021-00416-z	2021
	Harnessing diversity and antagonism within the pig skin microbiota to identify novel mediators of colonization resistance to methicillin-resistant Staphylococcus aureus.	Wei M, Flowers L, Knight SAB, Zheng Q, Murga-Garrido S, Uberoi A, Pan JT, Walsh J, Schroeder E, Chu EW, Campbell A, Shin D, Bradley CW, Duran-Struuck R, Grice EA.	mSphere	10.1128/msphere.00177-23	2023
Transcriptome	Spatial transcriptomes and microbiota reveal immune mechanism that respond to pathogen infection in the posterior intestine of Sebastes schlegelii.	Cao M, Xue T, Huo H, Zhang X, Wang NN, Yan X, Li C.	Open Biol	10.1098/rsob.220302	2023
	The bacterial and archaeal communities of flies, manure, lagoons, and troughs at a working dairy	Crippen T, Kim D, Poole T, Swiger S, Anderson R.	Front Microbiol		2023
Metabolism	Systematic characterization of position one variants within the lantibiotic nisin.	Lagedroste M, Reiners J, Smits SHJ, Schmitt L.	Sci Rep	10.1038/s41598-018-37532-4	2019
Metabolism	Toxic but tasty - temporal dynamics and network architecture of heme-responsive two-component signaling in Corynebacterium glutamicum.	Keppel M, Piepenbreier H, Gatgens C, Fritz G, Frunzke J.	Mol Microbiol	10.1111/mmi.14226	2019
	Evaluation of 16S rRNA gene PCR sensitivity and specificity for diagnosis of prosthetic joint infection: a prospective multicenter cross-sectional study.	Bemer P, Plouzeau C, Tande D, Leger J, Giraudeau B, Valentin AS, Jolivet-Gougeon A, Vincent P, Corvec S, Gibaud S, Juvin ME, Hery-Arnaud G, Lemarie C, Kempf M, Bret L, Quentin R, Coffre C, de Pinieux G, Bernard L, Burucoa C, Centre de Reference des Infections Osteo-articulaires du Grand Ouest (CRIOGO) Study Team.	J Clin Microbiol	10.1128/jcm.01459-14	2014
Enzymology	Microbial burden and diversity of commercial airline cabin air during short and long durations of travel.	Osman S, La Duc MT, Dekas A, Newcombe D, Venkateswaran K.	ISME J	10.1038/ismej.2008.11	2008
Pathogenicity	Complete genome sequence, lifestyle, and multi-drug resistance of the human pathogen Corynebacterium resistens DSM 45100 isolated from blood samples of a leukemia patient.	Schroder J, Maus I, Meyer K, Wordemann S, Blom J, Jaenicke S, Schneider J, Trost E, Tauch A.	BMC Genomics	10.1186/1471-2164-13-141	2012
Enzymology	Discovery, Production and Modification of Five Novel Lantibiotics Using the Promiscuous Nisin Modification Machinery.	van Heel AJ, Kloosterman TG, Montalban-Lopez M, Deng J, Plat A, Baudu B, Hendriks D, Moll GN, Kuipers OP	ACS Synth Biol	10.1021/acssynbio.6b00033	2016
Genetics	Pradimicin U, a promising antimicrobial agent isolated from a newly found Nonomuraea composti sp. nov.	Duangupama T, Pittayakhajonwut P, Intaraudom C, Suriyachadkun C, Tadtong S, Kuncharoen N, He YW, Tanasupawat S, Thawai C.	Sci Rep	10.1038/s41598-024-60744-w	2024
Genetics	Corynebacterium senegalense sp. nov. and Arthrobacter senegalensis sp. nov., two new Actinobacteria isolated from skin swab from the palm of hand.	Ndiaye C, Fall NS, Kuete E, Lo CI, Raoult D, Sokhna C, Lagier JC.	New Microbes New Infect	10.1016/j.nmni.2019.100583	2019
Genetics	Genome sequence and description of Corynebacterium ihumii sp. nov.	Padmanabhan R, Dubourg G, Lagier JC, Couderc C, Michelle C, Raoult D, Fournier PE.	Stand Genomic Sci	10.4056/sigs.5149006	2014
Phylogeny	Isolation of Corynebacterium tuscaniae sp. nov. from blood cultures of a patient with endocarditis.	Riegel P, Creti R, Mattei R, Nieri A, von Hunolstein C.	J Clin Microbiol	10.1128/jcm.44.2.307-312.2006	2006
Phylogeny	Corynebacterium timonense sp. nov. and Corynebacterium massiliense sp. nov., isolated from human blood and human articular hip fluid.	Merhej V, Falsen E, Raoult D, Roux V.	Int J Syst Evol Microbiol	10.1099/ijs.0.005827-0	2009
Phylogeny	Corynebacterium lizhenjunii sp. nov., isolated from the respiratory tract of Marmota himalayana, and Corynebacterium qintianiae sp. nov., isolated from the lung tissue of Pseudois nayaur.	Zhou J, Xu M, Guo W, Yang J, Pu J, Lai XH, Jin D, Lu S, Zhang S, Huang Y, Zhu W, Huang Y, Zheng H, Xu J	Int J Syst Evol Microbiol	10.1099/ijsem.0.004803	2021
Phylogeny	Corynebacterium gottingense sp. nov., isolated from a clinical patient.	Atasayar E, Zimmermann O, Sproer C, Schumann P, Gross U	Int J Syst Evol Microbiol	10.1099/ijsem.0.002322	2017
Phylogeny	Corynebacterium lipophiloflavum sp. nov. isolated from a patient with bacterial vaginosis.	Funke G, Hutson RA, Hilleringmann M, Heizmann WR, Collins MD	FEMS Microbiol Lett	10.1016/s0378-1097(97)00118-3	1997

References

#11648	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 44291
#19647	Wink, J.: Compendium of Actinobacteria. HZI-Helmholtz-Centre for Infection Research, Braunschweig .
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#37203	; Curators of the CIP;
#53613	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 37336
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68379	Automatically annotated from API Coryne .
#68382	Automatically annotated from API zym .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120622	Collection of Institut Pasteur ; Curators of the CIP; CIP 105127
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Corynebacterium lipophiloflavum (DSM 44291, CCUG 37336, DMMZ 1944)

Name and taxonomic classification

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Oxygen tolerance

Halophily

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API coryne

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