Clostridium kluyveri (DSM 555, ATCC 12489, ATCC 8527)

Name: Clostridium kluyveri (DSM 555, ATCC 12489, ATCC 8527)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 2606

Type strain

Strain Designation K1

Culture col. no. DSM 555 ATCC 12489 ATCC 8527 NCIMB 10680 K1

NCBI tax ID(s) 431943 1534

Special Collections DSMZ

History <- S. Schoberth, Universität Göttingen, Germany; K1 <- G. Gottschalk <- H. A. Barker, University of California, Berkeley, USA

Links

Clostridium kluyveri K1 is an anaerobe bacterium that was isolated from mud.

anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 34982

ATCC 8527,ATCC 12489,NCIB 10680,DSM 555,NCIMB 10680,IFO 12016,LMD 46.95,LMD 72.61,NCCB 46095,NCCB 72061,NBRC 12016,BCRC 14472,CCRC 14472

@ref 20215

Last LPSN update 2026-02-09 11:18:19

Domain Bacteria

Phylum Bacillota

Class Clostridia

Order Eubacteriales

Family Clostridiaceae

Genus Clostridium

Species Clostridium kluyveri

Full scientific name Clostridium kluyveri Barker and Taha 1942 (Approved Lists 1980)

BacDive ID	Other strains from **Clostridium kluyveri** (5)	Type strain
2607	C. kluyveri 1, DSM 556
2608	C. kluyveri 2, DSM 557
2609	C. kluyveri 22, DSM 562
2610	C. kluyveri 27, DSM 563
2611	C. kluyveri 49, DSM 564

Morphology

Colony morphology

276

Incubation period1-2 days

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
276	CLOSTRIDIUM KLUYVERI MEDIUM (DSMZ Medium 52)		Medium recipe at MediaDive	Name: CLOSTRIDIUM KLUYVERI MEDIUM (DSMZ Medium 52) Composition: K-acetate 10.0 g/l Yeast extract 1.0 g/l Na2CO3 1.0 g/l K2HPO4 0.31 g/l L-Cysteine HCl x H2O 0.25 g/l NH4Cl 0.25 g/l Na2S x 9 H2O 0.25 g/l KH2PO4 0.23 g/l MgSO4 x 7 H2O 0.2 g/l HCl 0.0025 g/l FeCl2 x 4 H2O 0.0015 g/l Sodium resazurin 0.0005 g/l NaOH 0.0005 g/l Pyridoxine hydrochloride 0.0003 g/l Thiamine-HCl x 2 H2O 0.0002 g/l Nicotinic acid 0.0002 g/l CoCl2 x 6 H2O 0.00019 g/l Calcium pantothenate 0.0001 g/l MnCl2 x 4 H2O 0.0001 g/l Vitamin B12 0.0001 g/l p-Aminobenzoic acid 8e-05 g/l ZnCl2 7e-05 g/l Na2MoO4 x 2 H2O 3.6e-05 g/l NiCl2 x 6 H2O 2.4e-05 g/l D-(+)-biotin 2e-05 g/l H3BO3 6e-06 g/l Na2WO4 x 2 H2O 4e-06 g/l Na2SeO3 x 5 H2O 3e-06 g/l CuCl2 x 2 H2O 2e-06 g/l Ethanol absolute Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
276	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
276	anaerobe
125439	facultative anaerobe	96.4

Compound production

@ref	Compound
276	acetaldehyde dehydrogenase
276	ß hydroxybutyryl-CoA dehydrogenase
276	diaphorase
276	phosphotransacetylase
276	vinylacetyl isomerase
276	flavin nucleotides, radioactive
276	enoate reductase

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	C4 and CAM-carbon fixation	100	8 of 8
66794	palmitate biosynthesis	100	22 of 22
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	ppGpp biosynthesis	100	4 of 4
66794	CMP-KDO biosynthesis	100	4 of 4
66794	cardiolipin biosynthesis	100	7 of 7
66794	methylglyoxal degradation	100	5 of 5
66794	aminopropanol phosphate biosynthesis	100	2 of 2
66794	adipate degradation	100	2 of 2
66794	lipoate biosynthesis	100	5 of 5
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	folate polyglutamylation	100	1 of 1
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	threonine metabolism	100	10 of 10
66794	vitamin B1 metabolism	92.31	12 of 13
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	gluconeogenesis	87.5	7 of 8
66794	isoleucine metabolism	87.5	7 of 8
66794	alanine metabolism	86.21	25 of 29
66794	propanol degradation	85.71	6 of 7
66794	reductive acetyl coenzyme A pathway	85.71	6 of 7
66794	vitamin B12 metabolism	85.29	29 of 34
66794	glutamate and glutamine metabolism	82.14	23 of 28
66794	starch degradation	80	8 of 10
66794	cellulose degradation	80	4 of 5
66794	flavin biosynthesis	80	12 of 15
66794	peptidoglycan biosynthesis	80	12 of 15
66794	glycogen metabolism	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	heme metabolism	78.57	11 of 14
66794	valine metabolism	77.78	7 of 9
66794	NAD metabolism	77.78	14 of 18
66794	d-mannose degradation	77.78	7 of 9
66794	pyrimidine metabolism	77.78	35 of 45
66794	phenylalanine metabolism	76.92	10 of 13
66794	acetate fermentation	75	3 of 4
66794	biotin biosynthesis	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	butanoate fermentation	75	3 of 4
66794	purine metabolism	73.4	69 of 94
66794	citric acid cycle	71.43	10 of 14
66794	serine metabolism	66.67	6 of 9
66794	methane metabolism	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	enterobactin biosynthesis	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	tryptophan metabolism	65.79	25 of 38
66794	histidine metabolism	65.52	19 of 29
66794	methionine metabolism	65.38	17 of 26
66794	glycolysis	64.71	11 of 17
66794	lipid metabolism	64.52	20 of 31
66794	glutathione metabolism	64.29	9 of 14
66794	proline metabolism	63.64	7 of 11
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	ketogluconate metabolism	62.5	5 of 8
66794	arginine metabolism	62.5	15 of 24
66794	leucine metabolism	61.54	8 of 13
66794	oxidative phosphorylation	61.54	56 of 91
66794	urea cycle	61.54	8 of 13
66794	phenylacetate degradation (aerobic)	60	3 of 5
66794	factor 420 biosynthesis	60	3 of 5
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	hydrogen production	60	3 of 5
66794	non-pathway related	57.89	22 of 38
66794	tetrahydrofolate metabolism	57.14	8 of 14
66794	degradation of sugar alcohols	56.25	9 of 16
66794	cysteine metabolism	55.56	10 of 18
66794	lysine metabolism	54.76	23 of 42
66794	pentose phosphate pathway	54.55	6 of 11
66794	sulfate reduction	53.85	7 of 13
66794	phosphatidylethanolamine bioynthesis	53.85	7 of 13
66794	selenocysteine biosynthesis	50	3 of 6
66794	pantothenate biosynthesis	50	3 of 6
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	phenylmercury acetate degradation	50	1 of 2
66794	glycine metabolism	50	5 of 10
66794	Entner Doudoroff pathway	50	5 of 10
66794	isoprenoid biosynthesis	50	13 of 26
66794	quinate degradation	50	1 of 2
66794	sulfopterin metabolism	50	2 of 4
66794	toluene degradation	50	2 of 4
66794	kanosamine biosynthesis II	50	1 of 2
66794	4-hydroxyphenylacetate degradation	50	5 of 10
66794	ethanol fermentation	50	1 of 2
66794	nitrate assimilation	44.44	4 of 9
66794	ubiquinone biosynthesis	42.86	3 of 7
66794	tyrosine metabolism	42.86	6 of 14
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	arachidonate biosynthesis	40	2 of 5
66794	propionate fermentation	40	4 of 10
66794	bacilysin biosynthesis	40	2 of 5
66794	phenylpropanoid biosynthesis	38.46	5 of 13
66794	carnitine metabolism	37.5	3 of 8
66794	molybdenum cofactor biosynthesis	33.33	3 of 9
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	lipid A biosynthesis	33.33	3 of 9
66794	sphingosine metabolism	33.33	2 of 6
66794	IAA biosynthesis	33.33	1 of 3
66794	allantoin degradation	33.33	3 of 9
66794	ascorbate metabolism	31.82	7 of 22
66794	polyamine pathway	30.43	7 of 23
66794	coenzyme M biosynthesis	30	3 of 10
66794	myo-inositol biosynthesis	30	3 of 10
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	aclacinomycin biosynthesis	28.57	2 of 7
66794	degradation of hexoses	27.78	5 of 18
66794	metabolism of disaccharids	27.27	3 of 11
66794	vitamin B6 metabolism	27.27	3 of 11
66794	dTDPLrhamnose biosynthesis	25	2 of 8
66794	cyclohexanol degradation	25	1 of 4
66794	lactate fermentation	25	1 of 4
66794	vitamin E metabolism	25	1 of 4
66794	4-hydroxymandelate degradation	22.22	2 of 9
66794	degradation of pentoses	21.43	6 of 28

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Terrestrial	#Mud (Sludge)

Isolation

276

Sample typemud

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
276	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM1026v1 assembly for Clostridium kluyveri NBRC 12016	complete	GCA_000010265	583346.6	643348529	583346	98.53
66792	ASM1650v1 assembly for Clostridium kluyveri DSM 555	complete	GCA_000016505	431943.8	640753020	431943	98.48

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Clostridium kluyveri strain DSM 555 16S ribosomal RNA gene, partial sequence	DQ911271	320		431943
20218	Clostridium kluyveri 16S ribosomal RNA	M59092	1460		1534

GC content

276

GC-content (mol%)29.8

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Clostridium kluyveri DSM 555
PATRIC: 431943.8

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	88.20	no
125439	motility	BacteriaNetⓘ	yes	82.60	no
125439	gram_stain	BacteriaNetⓘ	positive	64.10	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	96.40	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Clostridium kluyveri DSM 555 DSM 555
NCBI: GCA_000016505.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	56.65	no
125438	anaerobic	anaerobicⓘ	yes	87.09	no
125438	aerobic	aerobicⓘ	no	95.01	yes
125438	spore-forming	spore-formingⓘ	yes	77.59	no
125438	thermophilic	thermophileⓘ	no	85.69	yes
125438	flagellated	motile2+ⓘ	yes	75.07	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Metabolism	Protocol to obtain genetically engineered Acetobacterium woodii and Eubacterium callanderi strains.	Baur KS, Ruhle B, Reith T, Krieg A, Bengelsdorf FR.	STAR Protoc	10.1016/j.xpro.2025.104011	2025
	Immobilization and Monitoring of Clostridium carboxidivorans and Clostridium kluyveri in Synthetic Biofilms.	Herzog J, Jakel AC, Simmel FC, Weuster-Botz D.	Microorganisms	10.3390/microorganisms13020387	2025
	Caproate production from Enset fiber in one-pot two-step fermentation using anaerobic fungi (Neocallimastix cameroonii strain G341) and Clostridium kluyveri DSM 555.	Seid N, Ochsenreither K, Neumann A.	Microb Cell Fact	10.1186/s12934-023-02224-w	2023
	Variability in n-caprylate and n-caproate producing microbiomes in reactors with in-line product extraction.	Spirito CM, Lucas TN, Patz S, Jeon BS, Werner JJ, Trondsen LH, Guzman JJ, Huson DH, Angenent LT.	mSystems	10.1128/msystems.00416-24	2024
	Butanol as a major product during ethanol and acetate chain elongation.	Robles A, Sundar SV, Mohana Rangan S, Delgado AG.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1181983	2023
	Physiological and stoichiometric characterization of ethanol-based chain elongation in the absence of short-chain carboxylic acids.	Allaart MT, Fox BB, Nettersheim IHMS, Pabst M, Sousa DZ, Kleerebezem R.	Sci Rep	10.1038/s41598-023-43682-x	2023
	Synthetic co-culture of autotrophic Clostridium carboxidivorans and chain elongating Clostridium kluyveri monitored by flow cytometry.	Baumler M, Schneider M, Ehrenreich A, Liebl W, Weuster-Botz D.	Microb Biotechnol	10.1111/1751-7915.13941	2022
	Effect of Multiple Rounds of Enrichment on Metabolite Accumulation and Microbiota Composition of Pit Mud for Baijiu Fermentation.	Li D, Ye G, Zong X, Zou W.	Foods	10.3390/foods12081594	2023
	Acetogenic production of 3-Hydroxybutyrate using a native 3-Hydroxybutyryl-CoA Dehydrogenase.	Lo J, Humphreys JR, Magnusson L, Wachter B, Urban C, Hebdon SD, Xiong W, Chou KJ, Ching Maness P.	Front Microbiol	10.3389/fmicb.2022.948369	2022
	Enrichment Versus Bioaugmentation-Microbiological Production of Caproate from Mixed Carbon Sources by Mixed Bacterial Culture and Clostridium kluyveri.	Zagrodnik R, Duber A, Lezyk M, Oleskowicz-Popiel P.	Environ Sci Technol	10.1021/acs.est.9b07651	2020
	The occurrence and ecology of microbial chain elongation of carboxylates in soils.	Joshi S, Robles A, Aguiar S, Delgado AG.	ISME J	10.1038/s41396-021-00893-2	2021
	Continuous Production of Ethanol, 1-Butanol and 1-Hexanol from CO with a Synthetic Co-Culture of Clostridia Applying a Cascade of Stirred-Tank Bioreactors.	Baumler M, Burgmaier V, Herrmann F, Mentges J, Schneider M, Ehrenreich A, Liebl W, Weuster-Botz D.	Microorganisms	10.3390/microorganisms11041003	2023
	Metabolic shift induced by synthetic co-cultivation promotes high yield of chain elongated acids from syngas.	Diender M, Parera Olm I, Gelderloos M, Koehorst JJ, Schaap PJ, Stams AJM, Sousa DZ.	Sci Rep	10.1038/s41598-019-54445-y	2019
	The Restriction-Modification Systems of Clostridium carboxidivorans P7.	Kottenhahn P, Philipps G, Bunk B, Sproer C, Jennewein S.	Microorganisms	10.3390/microorganisms11122962	2023
Metabolism	Functional analysis of multiple nifB genes of Paenibacillus strains in synthesis of Mo-, Fe- and V-nitrogenases.	Li Q, Zhang H, Zhang L, Chen S.	Microb Cell Fact	10.1186/s12934-021-01629-9	2021
	A metagenome-level analysis of a microbial community fermenting ultra-filtered milk permeate.	Walters KA, Mohan G, Myers KS, Ingle AT, Donohue TJ, Noguera DR.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1173656	2023
	Heterologous Production of Isopropanol Using Metabolically Engineered Acetobacterium woodii Strains.	Hofele F, Schoch T, Oberlies C, Durre P.	Bioengineering (Basel)	10.3390/bioengineering10121381	2023
	Looking for the mechanism of arsenate respiration of Fusibacter sp. strain 3D3, independent of ArrAB.	Acosta-Grinok M, Vazquez S, Guiliani N, Marin S, Demergasso C.	Front Microbiol	10.3389/fmicb.2022.1029886	2022
	Production of medium-chain fatty acids and higher alcohols by a synthetic co-culture grown on carbon monoxide or syngas.	Diender M, Stams AJ, Sousa DZ.	Biotechnol Biofuels	10.1186/s13068-016-0495-0	2016
Metabolism	Analysis of the key enzymes of butyric and acetic acid fermentation in biogas reactors.	Gabris C, Bengelsdorf FR, Durre P.	Microb Biotechnol	10.1111/1751-7915.12299	2015
	Three Novel Clostridia Isolates Produce n-Caproate and iso-Butyrate from Lactate: Comparative Genomics of Chain-Elongating Bacteria.	Liu B, Popp D, Muller N, Strauber H, Harms H, Kleinsteuber S.	Microorganisms	10.3390/microorganisms8121970	2020
Enzymology	Cryptic polyketide synthase genes in non-pathogenic Clostridium SPP.	Behnken S, Hertweck C.	PLoS One	10.1371/journal.pone.0029609	2012
Metabolism	Microbial Upgrading of Acetate into Value-Added Products-Examining Microbial Diversity, Bioenergetic Constraints and Metabolic Engineering Approaches.	Kutscha R, Pflugl S.	Int J Mol Sci	10.3390/ijms21228777	2020
Enzymology	Comparative Proteomic Analysis of Desulfotomaculum reducens MI-1: Insights into the Metabolic Versatility of a Gram-Positive Sulfate- and Metal-Reducing Bacterium.	Otwell AE, Callister SJ, Zink EM, Smith RD, Richardson RE.	Front Microbiol	10.3389/fmicb.2016.00191	2016
Genetics	Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids.	Yoshida T, Claverie JM, Ogata H.	Virol J	10.1186/1743-422x-8-427	2011
Genetics	Uneven distribution of cobamide biosynthesis and dependence in bacteria predicted by comparative genomics.	Shelton AN, Seth EC, Mok KC, Han AW, Jackson SN, Haft DR, Taga ME.	ISME J	10.1038/s41396-018-0304-9	2019
	Classifying the metal dependence of uncharacterized nitrogenases.	McGlynn SE, Boyd ES, Peters JW, Orphan VJ.	Front Microbiol	10.3389/fmicb.2012.00419	2012
Metabolism	NADP+ reduction with reduced ferredoxin and NADP+ reduction with NADH are coupled via an electron-bifurcating enzyme complex in Clostridium kluyveri.	Wang S, Huang H, Moll J, Thauer RK.	J Bacteriol	10.1128/jb.00612-10	2010
Genetics	Applying the ResFinder and VirulenceFinder web-services for easy identification of acquired antibiotic resistance and E. coli virulence genes in bacteriophage and prophage nucleotide sequences.	Kleinheinz KA, Joensen KG, Larsen MV.	Bacteriophage	10.4161/bact.27943	2014
	Teth137, a Conserved Factor of Unknown Function from Thermoanaerobacter ethanolicus JW200, Represses the Transcription of the adhE Gene In Vitro.	Jing Q, Wang J, Wu G.	Indian J Microbiol	10.1007/s12088-012-0339-y	2013
	Unique Evolution of Symbiobacterium thermophilum Suggested from Gene Content and Orthologous Protein Sequence Comparisons.	Oshima K, Ueda K, Beppu T, Nishida H.	Int J Evol Biol	10.4061/2011/376831	2010
	Metabolic engineering of Clostridium ljungdahlii for the production of hexanol and butanol from CO₂ and H₂.	Lauer I, Philipps G, Jennewein S.	Microb Cell Fact	10.1186/s12934-022-01802-8	2022
	Challenges of ligand identification for riboswitch candidates.	Meyer MM, Hammond MC, Salinas Y, Roth A, Sudarsan N, Breaker RR.	RNA Biol	10.4161/rna.8.1.13865	2011
Enzymology	Occurrence of L-iduronic acid and putative D-glucuronyl C5-epimerases in prokaryotes.	Raedts J, Kengen SW, van der Oost J.	Glycoconj J	10.1007/s10719-011-9324-7	2011
Genetics	Characterization of the central metabolic pathways in Thermoanaerobacter sp. strain X514 via isotopomer-assisted metabolite analysis.	Feng X, Mouttaki H, Lin L, Huang R, Wu B, Hemme CL, He Z, Zhang B, Hicks LM, Xu J, Zhou J, Tang YJ.	Appl Environ Microbiol	10.1128/aem.00715-09	2009
Metabolism	Natural products from anaerobes.	Li JS, Barber CC, Zhang W.	J Ind Microbiol Biotechnol	10.1007/s10295-018-2086-5	2019
Metabolism	Coupled ferredoxin and crotonyl coenzyme A (CoA) reduction with NADH catalyzed by the butyryl-CoA dehydrogenase/Etf complex from Clostridium kluyveri.	Li F, Hinderberger J, Seedorf H, Zhang J, Buckel W, Thauer RK.	J Bacteriol	10.1128/jb.01417-07	2008
Metabolism	Genome mining for ribosomally synthesized and post-translationally modified peptides (RiPPs) in anaerobic bacteria.	Letzel AC, Pidot SJ, Hertweck C.	BMC Genomics	10.1186/1471-2164-15-983	2014
Genetics	Genome sequence of Desulfitobacterium hafniense DCB-2, a Gram-positive anaerobe capable of dehalogenation and metal reduction.	Kim SH, Harzman C, Davis JK, Hutcheson R, Broderick JB, Marsh TL, Tiedje JM.	BMC Microbiol	10.1186/1471-2180-12-21	2012
Phylogeny	Comparative metagenomics of biogas-producing microbial communities from production-scale biogas plants operating under wet or dry fermentation conditions.	Stolze Y, Zakrzewski M, Maus I, Eikmeyer F, Jaenicke S, Rottmann N, Siebner C, Puhler A, Schluter A.	Biotechnol Biofuels	10.1186/s13068-014-0193-8	2015
	Conserved amino acid sequence features in the alpha subunits of MoFe, VFe, and FeFe nitrogenases.	Glazer AN, Kechris KJ.	PLoS One	10.1371/journal.pone.0006136	2009
	Gene conservation among endospore-forming bacteria reveals additional sporulation genes in Bacillus subtilis.	Traag BA, Pugliese A, Eisen JA, Losick R.	J Bacteriol	10.1128/jb.01778-12	2013
Metabolism	Clostridium sticklandii, a specialist in amino acid degradation:revisiting its metabolism through its genome sequence.	Fonknechten N, Chaussonnerie S, Tricot S, Lajus A, Andreesen JR, Perchat N, Pelletier E, Gouyvenoux M, Barbe V, Salanoubat M, Le Paslier D, Weissenbach J, Cohen GN, Kreimeyer A.	BMC Genomics	10.1186/1471-2164-11-555	2010
Genetics	Unsupervised statistical discovery of spaced motifs in prokaryotic genomes.	Tong H, Schliekelman P, Mrazek J.	BMC Genomics	10.1186/s12864-016-3400-0	2017
Transcriptome	The purine-utilizing bacterium Clostridium acidurici 9a: a genome-guided metabolic reconsideration.	Hartwich K, Poehlein A, Daniel R.	PLoS One	10.1371/journal.pone.0051662	2012
Metabolism	Two new families of the FtsZ-tubulin protein superfamily implicated in membrane remodeling in diverse bacteria and archaea.	Makarova KS, Koonin EV.	Biol Direct	10.1186/1745-6150-5-33	2010
Genetics	Natural products genomics.	Siezen RJ, Khayatt BI.	Microb Biotechnol	10.1111/j.1751-7915.2008.00044.x	2008
	Prophage-stimulated toxin production in Clostridium difficile NAP1/027 lysogens.	Sekulovic O, Meessen-Pinard M, Fortier LC.	J Bacteriol	10.1128/jb.00787-10	2011
Pathogenicity	Transcriptional attenuation controls macrolide inducible efflux and resistance in Streptococcus pneumoniae and in other Gram-positive bacteria containing mef/mel(msr(D)) elements.	Chancey ST, Bai X, Kumar N, Drabek EF, Daugherty SC, Colon T, Ott S, Sengamalay N, Sadzewicz L, Tallon LJ, Fraser CM, Tettelin H, Stephens DS.	PLoS One	10.1371/journal.pone.0116254	2015
Genetics	Tracing lifestyle adaptation in prokaryotic genomes.	Altermann E.	Front Microbiol	10.3389/fmicb.2012.00048	2012
Metabolism	Distribution of glucan-branching enzymes among prokaryotes.	Suzuki E, Suzuki R.	Cell Mol Life Sci	10.1007/s00018-016-2243-9	2016
	Crystal structures of beta-carboxysome shell protein CcmP: ligand binding correlates with the closed or open central pore.	Larsson AM, Hasse D, Valegard K, Andersson I.	J Exp Bot	10.1093/jxb/erx070	2017
Genetics	Information theoretic perspective on genome clustering.	Veluchamy A, Mehta P, Srividhya KV, Vikram H, Govind MK, Gupta R, Aziz Bin Dukhyil A, Abdullah Alharbi R, Abdullah Aloyuni S, Hassan MM, Krishnaswamy S.	Saudi J Biol Sci	10.1016/j.sjbs.2020.12.039	2021
Metabolism	Molecular analysis of the anaerobic succinate degradation pathway in Clostridium kluyveri.	Sohling B, Gottschalk G.	J Bacteriol	10.1128/jb.178.3.871-880.1996	1996
Phylogeny	Phylogenetic distribution and membrane topology of the LytR-CpsA-Psr protein family.	Hubscher J, Luthy L, Berger-Bachi B, Stutzmann Meier P.	BMC Genomics	10.1186/1471-2164-9-617	2008
Pathogenicity	Tolerance of Listeria monocytogenes to Quaternary Ammonium Sanitizers Is Mediated by a Novel Efflux Pump Encoded by emrE.	Kovacevic J, Ziegler J, Walecka-Zacharska E, Reimer A, Kitts DD, Gilmour MW.	Appl Environ Microbiol	10.1128/aem.03741-15	2016
Metabolism	Identification of surprisingly diverse type IV pili, across a broad range of gram-positive bacteria.	Imam S, Chen Z, Roos DS, Pohlschroder M.	PLoS One	10.1371/journal.pone.0028919	2011
Metabolism	Deciphering Clostridium tyrobutyricum Metabolism Based on the Whole-Genome Sequence and Proteome Analyses.	Lee J, Jang YS, Han MJ, Kim JY, Lee SY.	mBio	10.1128/mbio.00743-16	2016
	The tryptophan pathway genes of the Sargasso Sea metagenome: new operon structures and the prevalence of non-operon organization.	Kagan J, Sharon I, Beja O, Kuhn JC.	Genome Biol	10.1186/gb-2008-9-1-r20	2008
Biotechnology	Unpublished but public microbial genomes with biotechnological relevance.	Siezen RJ, Wilson G.	Microb Biotechnol	10.1111/j.1751-7915.2008.00034.x	2008
	Horizontal gene transfer of zinc and non-zinc forms of bacterial ribosomal protein S4.	Chen K, Roberts E, Luthey-Schulten Z.	BMC Evol Biol	10.1186/1471-2148-9-179	2009
Genetics	Phylogenetic distribution and evolutionary history of bacterial DEAD-Box proteins.	Lopez-Ramirez V, Alcaraz LD, Moreno-Hagelsieb G, Olmedo-Alvarez G.	J Mol Evol	10.1007/s00239-011-9441-8	2011
Metabolism	Directed networks reveal genomic barriers and DNA repair bypasses to lateral gene transfer among prokaryotes.	Popa O, Hazkani-Covo E, Landan G, Martin W, Dagan T.	Genome Res	10.1101/gr.115592.110	2011
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Transcriptome	In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.	Marsh AJ, O'Sullivan O, Ross RP, Cotter PD, Hill C.	BMC Genomics	10.1186/1471-2164-11-679	2010
Enzymology	Coenzyme A-acylating aldehyde dehydrogenase from Clostridium beijerinckii NRRL B592.	Yan RT, Chen JS.	Appl Environ Microbiol	10.1128/aem.56.9.2591-2599.1990	1990
	Molecular characterization of an aldehyde/alcohol dehydrogenase gene from Clostridium acetobutylicum ATCC 824.	Nair RV, Bennett GN, Papoutsakis ET.	J Bacteriol	10.1128/jb.176.3.871-885.1994	1994
Genetics	Stemming epigenetics in marine stramenopiles.	Maumus F, Rabinowicz P, Bowler C, Rivarola M.	Curr Genomics	10.2174/138920211796429727	2011
	In silico analysis of methyltransferase domains involved in biosynthesis of secondary metabolites.	Ansari MZ, Sharma J, Gokhale RS, Mohanty D.	BMC Bioinformatics	10.1186/1471-2105-9-454	2008
	Evolution of the oligopeptide transporter family.	Gomolplitinant KM, Saier MH.	J Membr Biol	10.1007/s00232-011-9347-9	2011
	Species-specific ribosomal RNA-FISH identifies interspecies cellular-material exchange, active-cell population dynamics and cellular localization of translation machinery in clostridial cultures and co-cultures.	Hill JD, Hill JD, Papoutsakis ET.	mSystems	10.1128/msystems.00572-24	2024
	The potential of caproate (hexanoate) production using Clostridium kluyveri syntrophic cocultures with Clostridium acetobutylicum or Clostridium saccharolyticum.	Otten JK, Zou Y, Papoutsakis ET.	Front Bioeng Biotechnol	10.3389/fbioe.2022.965614	2022
	Upgrading syngas fermentation effluent using Clostridium kluyveri in a continuous fermentation.	Gildemyn S, Molitor B, Usack JG, Nguyen M, Rabaey K, Angenent LT.	Biotechnol Biofuels	10.1186/s13068-017-0764-6	2017
Genetics	Mining of Microbial Genomes for the Novel Sources of Nitrilases.	Sharma N, Thakur N, Raj T, Savitri, Bhalla TC.	Biomed Res Int	10.1155/2017/7039245	2017
Metabolism	Dehydrogenases involved in the conversion of succinate to 4-hydroxybutanoate by Clostridium kluyveri.	Wolff RA, Urben GW, O'Herrin SM, Kenealy WR.	Appl Environ Microbiol	10.1128/aem.59.6.1876-1882.1993	1993
Metabolism	Ammonia assimilation pathways in nitrogen-fixing Clostridium kluyverii and Clostridium butyricum.	Kanamori K, Weiss RL, Roberts JD.	J Bacteriol	10.1128/jb.171.4.2148-2154.1989	1989
Enzymology	Distribution of coenzyme B12-dependent diol dehydratase and glycerol dehydratase in selected genera of Enterobacteriaceae and Propionibacteriaceae.	Toraya T, Kuno S, Fukui S.	J Bacteriol	10.1128/jb.141.3.1439-1442.1980	1980
Transcriptome	A novel mechanistic insight into CO₂ effects on chain elongation in Clostridium kluyveri based on transcriptomic and ¹³C-targeted metabolomic analyses.	Huo W, Ye R, Hu T, Shao Y, Zheng Z, Zhang R, Lu W, Shen Q.	Water Res	10.1016/j.watres.2025.125007	2025
	Impact of acetogenic partner and pH on syngas fermentation in Clostridium kluyveri co-cultures.	Peek S, Parera Olm I, Diender M, Sousa DZ.	Bioresour Technol	10.1016/j.biortech.2025.133488	2025
	Enhanced electron transfer mediated by surface functional groups of targetedly modified sludge-based biochar for sustainable microbial chain elongation.	Meng F, Wang L, Xu J, Li X, Hao J.	Bioresour Technol	10.1016/j.biortech.2025.133600	2025
	Fe₃O₄-Enhanced Continuous Production of Medium-chain Fatty Acids from Sludge: Metagenomic Perspective on Microbial Synergy.	Chen Z, Zhu S, Gao S, Wu H, Tian S, Wen X.	Bioresour Technol	10.1016/j.biortech.2025.133673	2025
	Development of Photobacterium sp. LN01 as a Versatile Halophilic Platform for Tunable Biosynthesis of Polyhydroxyalkanoates.	Wang MR, Tao S, Lin N, Song X, Li ZJ.	ACS Synth Biol	10.1021/acssynbio.5c00562	2025
	Microbial-electrochemical driven simultaneous biogas upgrading and high-value medium-chain carboxylic acid production.	Wang YR, Chen C, Wu ST, Wang ZH, Zhao L, Tong J, Wu KK, Xing DF, Wang AJ, Ren NQ.	Bioresour Technol	10.1016/j.biortech.2025.133526	2026
	Constructing simplified microbial consortia that couple lactic acid and ethanol utilization to highly produce caproic acid from liquor-making wastewater.	Xiang J, Zhou Z, Liu Z, Ren C, Xu Y.	Water Res	10.1016/j.watres.2025.123973	2025
	Molecular Chain Elongation Mechanism for n-Caproate Biosynthesis by Megasphaera Hexanoica.	Jeon BS, Kim EJ, Seo H, Kim H, Shin S, Schlaiss C, Angenent LT, Kim KJ, Sang BI.	Adv Sci (Weinh)	10.1002/advs.202506069	2025
Enzymology	Metabolic Engineering of Clostridium tyrobutyricum for High-Yield n-Butanol Production by Increasing Intracellular Reducing Equivalent with NADPH-Dependent 3-Hydroxybutyryl-CoA Dehydrogenase.	Feng J, Wang Q, Guo X, Hu J, Wang G, Lu L, Qin Z, Fu H, Wang J, Yang ST.	ACS Synth Biol	10.1021/acssynbio.5c00218	2025
	Effect of Saccharomyces cerevisiae inoculation on the co-fermentation of Clostridium kluyveri and Clostridium tyrobutyricum: A strategy for controlling acidity and enhancing aroma in strong-flavor Baijiu.	Qiu F, Li W, Zhang Y, Li H, Chen X, Niu J, Li X, Sun B.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2025.111172	2025
Enzymology	Ultrahigh-throughput screening assay for PET-degrading enzymes.	Lorente-Arevalo A, Gimeno-Perez M, Ortega C, Finnigan J, Charnock S, Hidalgo A.	Methods Enzymol	10.1016/bs.mie.2025.01.021	2025
	Comprehensive comparative study on n-caproate production by Clostridium kluyveri: batch vs. continuous operation modes.	Fernandez-Blanco C, Pereira A, Veiga MC, Kennes C, Ganigue R.	Bioresour Technol	10.1016/j.biortech.2024.131138	2024
	Efficient caproic acid production from lignocellulosic biomass by bio-augmented mixed microorganisms.	Liu T, Li J, Hao X, Meng J.	Bioresour Technol	10.1016/j.biortech.2024.130565	2024
	Carbon dioxide as key player in chain elongation and growth of Clostridium kluyveri: Insights from batch and bioreactor studies.	Fernandez-Blanco C, Veiga MC, Kennes C.	Bioresour Technol	10.1016/j.biortech.2023.130192	2024
	Improved sequential production of hydrogen and caproate by addition of biochar prepared from cornstalk residues.	Du J, Xu PP, Ren HY, Cao GL, Xie GJ, Ren NQ, Liu BF.	Bioresour Technol	10.1016/j.biortech.2023.129702	2023
Genetics	Enhanced ethanol-driven carboxylate chain elongation by Pt@C in simulated sequencing batch reactors: Process and mechanism.	Huo W, Ye R, Shao Y, Bao M, Stegmann R, Lu W.	Bioresour Technol	10.1016/j.biortech.2023.129310	2023
Genetics	CO₂ uptake in ethanol-driven chain elongation system: Microbial metabolic mechanisms.	Huo W, Ye R, Hu T, Lu W.	Water Res	10.1016/j.watres.2023.120810	2023
	Clostridium kluyveri enhances caproate production by synergistically cooperating with acetogens in mixed microbial community of electro-fermentation system.	Zhang C, Liu H, Wu P, Li J, Zhang J.	Bioresour Technol	10.1016/j.biortech.2022.128436	2023
	Engineering the Biosynthesis of Daidzein and Genistein with the Red Oleaginous Yeast Rhodotorula toruloides.	Huang Y, Gao Q, Dong Y, Wang Y, Wang X, Yang X.	ACS Omega	10.1021/acsomega.5c05204	2025
	Mineral-Bound Trace Metals as Cofactors for Anaerobic Biological Nitrogen Fixation.	Sheng Y, Baars O, Guo D, Whitham J, Srivastava S, Dong H.	Environ Sci Technol	10.1021/acs.est.3c01371	2023
	A Living Semiartificial Photoelectrocatalytic Biohybrid for Solar CO₂ Fixation and Fermentation to Fatty Acids.	Burns C, Rishan M, Stevens L, Ashcroft E, Fuller L, Gibson EA, Kalathil S.	ACS Appl Mater Interfaces	10.1021/acsami.5c15023	2025
	Electro-Enhanced Gas Fermentation for Bioproduction of Volatile Fatty Acids and Alcohols.	Hiebl C, Fuchs W.	Microorganisms	10.3390/microorganisms13020249	2025
	Salt stress altered anaerobic microbial community and carbon metabolism characteristics: The trade-off between methanogenesis and chain elongation.	Guo H, Ji M, Du T, Xu W, Liu J, Bai R, Teng Z, Li T.	J Environ Manage	10.1016/j.jenvman.2023.118111	2023
	Monitoring co-cultures of Clostridium carboxidivorans and Clostridium kluyveri by fluorescence in situ hybridization with specific 23S rRNA oligonucleotide probes.	Schneider M, Baumler M, Lee NM, Weuster-Botz D, Ehrenreich A, Liebl W.	Syst Appl Microbiol	10.1016/j.syapm.2021.126271	2021
	Strategy of electron acceptors for ethanol-driven chain elongation from kitchen waste.	Huo W, Fu X, Bao M, Ye R, Shao Y, Liu Y, Bi J, Shi X, Lu W.	Sci Total Environ	10.1016/j.scitotenv.2022.157492	2022
	Efficient production of n-caproate from syngas by a co-culture of Clostridium aceticum and Clostridium kluyveri.	Fernandez-Blanco C, Veiga MC, Kennes C.	J Environ Manage	10.1016/j.jenvman.2021.113992	2022
	Guidelines in Designing a Universal Primer Mixture to Probe and Quantify Antibiotic-Resistant Genes Using the Polymerase Chain Reaction (PCR).	Hui A.	Cureus	10.7759/cureus.69479	2024
	Biochar and activated carbon enhance ethanol conversion and selectivity to caproic acid by Clostridium kluyveri.	Ghysels S, Buffel S, Rabaey K, Ronsse F, Ganigue R.	Bioresour Technol	10.1016/j.biortech.2020.124236	2021
	Metabolic engineering Saccharomyces cerevisiae for de novo biosynthesis of hydroxycinnamoyl glycerols.	Zou H, Xiao C, Zhao S.	Synth Syst Biotechnol	10.1016/j.synbio.2025.07.005	2025
	Fecal or bacterial transplantation in mice transfer environment-induced brain plasticity and associated behavioral changes.	Marrocco F, Khan R, Reccagni A, Lin X, Delli Carpini M, Iebba V, D'Alessandro G, Limatola C.	Front Physiol	10.3389/fphys.2025.1572854	2025
Genetics	Synthetic Microbial Cocultivation for Targeted Production of Odd-Chain Carboxylates and Alcohols from Carbon Monoxide.	Parera Olm I, Benito-Vaquerizo S, Dubaere C, Martins Dos Santos VAP, Suarez-Diez M, Sousa DZ.	Environ Sci Technol	10.1021/acs.est.4c14794	2025
	Effect of pH, yeast extract and inorganic carbon on chain elongation for hexanoic acid production.	San-Valero P, Abubackar HN, Veiga MC, Kennes C.	Bioresour Technol	10.1016/j.biortech.2019.122659	2020
Metabolism	Carbon chain elongation microorganism stimulates caproate production from ethanol and acetate under applied voltage regulation.	Li J, Luo X, Liu H, Zhang X, Tan H, Xiong X.	Front Microbiol	10.3389/fmicb.2025.1597990	2025
Phylogeny	Evolving the core microbial community in pit mud based on bioturbation of fortified Daqu.	Chen S, Huang J, Qin H, He G, Zhou R, Yang Y, Qiu C, Zhang S.	Can J Microbiol	10.1139/cjm-2020-0290	2021
	Influence of electron acceptors on hexanoic acid production by Clostridium kluyveri.	San-Valero P, Fernandez-Naveira A, Veiga MC, Kennes C.	J Environ Manage	10.1016/j.jenvman.2019.04.093	2019
	Enhancing Gas Fermentation Efficiency via Bioaugmentation with Megasphaera sueciensis and Clostridium carboxidivorans.	Hiebl C, Pinner D, Konegger H, Steger F, Mohamed D, Fuchs W.	Bioengineering (Basel)	10.3390/bioengineering12050470	2025
Metabolism	Immobilization of Clostridium kluyveri on wheat straw to alleviate ammonia inhibition during chain elongation for n-caproate production.	Zhang C, Yang L, Tsapekos P, Zhang Y, Angelidaki I.	Environ Int	10.1016/j.envint.2019.03.032	2019
	Inkjet-printed colorimetric indicators from the peels of red pitaya and Kyoho grape for the detection of food spoilage gases.	Gong T, Luo X.	Curr Res Food Sci	10.1016/j.crfs.2025.101064	2025
Enzymology	Single amino acid exchanges affect the substrate preference of an acetaldehyde dehydrogenase.	Hege D, Gemmecker Y, Schall I, Oppong-Nti P, Schmitt G, Heider J.	Appl Microbiol Biotechnol	10.1007/s00253-025-13468-4	2025
Genetics	Implementation of a Clostridium luticellarii genome-scale model for upgrading syngas fermentations.	Scott WT, Rockx S, Marien Q, Regueira A, Candry P, Ganigue R, Koehorst JJ, Schaap PJ.	Comput Struct Biotechnol J	10.1016/j.csbj.2025.01.013	2025
Metabolism	Performance and microbial characterization of two-stage caproate fermentation from fruit and vegetable waste via anaerobic microbial consortia.	Yu J, Huang Z, Wu P, Zhao M, Miao H, Liu C, Ruan W.	Bioresour Technol	10.1016/j.biortech.2019.03.124	2019
Phylogeny	Design, Optimization and Verification of 16S rRNA Oligonucleotide Probes of Fluorescence in-situ Hybridization for Targeting Clostridium spp. and Clostridium kluyveri.	Hu L, Huang J, Li H, Jin Y, Wu C, Zhou R.	J Microbiol Biotechnol	10.4014/jmb.1805.04057	2018
	Genome-scale metabolic reconstruction and analysis for Clostridium kluyveri.	Zou W, Ye G, Zhang J, Zhao C, Zhao X, Zhang K.	Genome	10.1139/gen-2017-0177	2018
	Microbial Recycling of Bioplastics via Mixed-Culture Fermentation of Hydrolyzed Polyhydroxyalkanoates into Carboxylates.	Jin Y, de Leeuw KD, Strik DPBTB.	Materials (Basel)	10.3390/ma16072693	2023
Metabolism	Biosynthesis and characterization of poly(d-lactate-co-glycolate-co-4-hydroxybutyrate).	Choi SY, Chae TU, Shin J, Im JA, Lee SY.	Biotechnol Bioeng	10.1002/bit.27354	2020
Enzymology	Accelerating Antimalarial Drug Discovery with a New High-Throughput Screen for Fast-Killing Compounds.	Sakura T, Ishii R, Yoshida E, Kita K, Kato T, Inaoka DK.	ACS Infect Dis	10.1021/acsinfecdis.4c00328	2024
	Bacterial diversity associated with volatile compound accumulation in pit mud of Chinese strong-flavor baijiu pit.	Shoubao Y, Yonglei J, Qi Z, Shunchang P, Cuie S.	AMB Express	10.1186/s13568-023-01508-z	2023
Genetics	Complete Genome Sequence of Clostridium kluyveri JZZ Applied in Chinese Strong-Flavor Liquor Production.	Wang Y, Li B, Dong H, Huang X, Chen R, Chen X, Yang L, Peng B, Xie G, Cheng W, Hao B, Li C, Xia J, Zhang B.	Curr Microbiol	10.1007/s00284-018-1539-4	2018
	Urban sports fields support higher levels of soil butyrate and butyrate-producing bacteria than urban nature parks.	Brame JE, Liddicoat C, Abbott CA, Cando-Dumancela C, Fickling NW, Robinson JM, Breed MF.	Ecol Evol	10.1002/ece3.70057	2024
	Caproic Acid-Producing Bacteria in Chinese Baijiu Brewing.	Yuan S, Jin Z, Ali A, Wang C, Liu J.	Front Microbiol	10.3389/fmicb.2022.883142	2022
Metabolism	Medium-Chain Fatty Acids (MCFA) Production Through Anaerobic Fermentation Using Clostridium kluyveri: Effect of Ethanol and Acetate.	Reddy MV, Mohan SV, Chang YC.	Appl Biochem Biotechnol	10.1007/s12010-017-2674-2	2018
	Fruity flavors from waste: A novel process to upgrade crude glycerol to ethyl valerate.	Ganigue R, Naert P, Candry P, de Smedt J, Stevens CV, Rabaey K.	Bioresour Technol	10.1016/j.biortech.2019.121574	2019
	Anaerobic HgII reduction is driven by cellular HgII-thiol interactions.	Lavoie NC, Poulain AJ.	Access Microbiol	10.1099/acmi.0.000932.v3	2025
Genetics	Unveiling the mechanisms of medium-chain fatty acid production from waste activated sludge alkaline fermentation liquor through physiological, thermodynamic and metagenomic investigations.	Wu SL, Sun J, Chen X, Wei W, Song L, Dai X, Ni BJ.	Water Res	10.1016/j.watres.2019.115218	2020
	Biological caproate production by Clostridium kluyveri from ethanol and acetate as carbon sources.	Yin Y, Zhang Y, Karakashev DB, Wang J, Angelidaki I.	Bioresour Technol	10.1016/j.biortech.2017.05.184	2017
	Upgrading dilute ethanol to odd-chain carboxylic acids by a synthetic co-culture of Anaerotignum neopropionicum and Clostridium kluyveri.	Parera Olm I, Sousa DZ.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02336-w	2023
	A Review on the Interaction of Acetic Acid Bacteria and Microbes in Food Fermentation: A Microbial Ecology Perspective.	Han D, Yang Y, Guo Z, Dai S, Jiang M, Zhu Y, Wang Y, Yu Z, Wang K, Rong C, Yu Y.	Foods	10.3390/foods13162534	2024
Metabolism	Adaptability of a Caproate-Producing Bacterium Contributes to Its Dominance in an Anaerobic Fermentation System.	Wang H, Gu Y, Zhou W, Zhao D, Qiao Z, Zheng J, Gao J, Chen X, Ren C, Xu Y.	Appl Environ Microbiol	10.1128/aem.01203-21	2021
	CO₂ supply is a powerful tool to control homoacetogenesis, chain elongation and solventogenesis in ethanol and carboxylate fed reactor microbiomes.	de Leeuw KD, van Willigen MJW, Vrauwdeunt T, Strik DPPTB.	Front Bioeng Biotechnol	10.3389/fbioe.2024.1329288	2024
Metabolism	Predicting and experimental evaluating bio-electrochemical synthesis - A case study with Clostridium kluyveri.	Koch C, Kuchenbuch A, Kracke F, Bernhardt PV, Kromer J, Harnisch F.	Bioelectrochemistry	10.1016/j.bioelechem.2017.07.009	2017
	Effect of pH and medium composition on chain elongation with Megasphaera hexanoica producing C₄-C₈ fatty acids.	Fernandez-Blanco C, Veiga MC, Kennes C.	Front Microbiol	10.3389/fmicb.2023.1281103	2023
	Cyclic dipeptides from endophytic bacterium Bacillus velezensis as potential flavor precursors.	Li T, Fang Y, Chai Z, Ji L, Jiang Z, Meng D, He B, Hu X, Xi H, Jia X, Li D.	Front Microbiol	10.3389/fmicb.2025.1565502	2025
Enzymology	Metabolic engineering of Escherichia coli for high-level production of benzyl acetate from glucose.	Ke Q, Liu C, Zhuang Y, Xue Y, Cui Z, Zhang C, Yin H, Liu T.	Microb Cell Fact	10.1186/s12934-024-02513-y	2024
	Synergistic activity of RSL3 and Pyrimethamine to inhibit the proliferation of Plasmodium falciparum.	Nikolova V, Linnemannstons K, Zahoruiko A, Ganter M, Luder CG, Dobbelstein M.	Antimicrob Agents Chemother	10.1128/aac.00471-25	2025
	Illuminating the Characteristics and Assembly of Prokaryotic Communities across a pH Gradient in Pit Muds for the Production of Chinese Strong-Flavor Baijiu.	Deng M, Hu X, Zhang Y, Zhang X, Ni H, Fu D, Chi L.	Foods	10.3390/foods13081196	2024
Metabolism	Deletion of Re-citrate synthase allows for analysis of contributions of tricarboxylic acid cycle directionality to the growth of Heliomicrobium modesticaldum.	Layton AM, McCauley C, Redding KE.	Appl Environ Microbiol	10.1128/aem.01772-24	2025
	Shaping microbial consortia in coupling glycerol fermentation and carboxylate chain elongation for Co-production of 1,3-propanediol and caproate: Pathways and mechanisms.	Leng L, Nobu MK, Narihiro T, Yang P, Amy Tan GY, Lee PH.	Water Res	10.1016/j.watres.2018.10.063	2019
Metabolism	Rex in Clostridium kluyveri is a global redox-sensing transcriptional regulator.	Hu L, Huang H, Yuan H, Tao F, Xie H, Wang S.	J Biotechnol	10.1016/j.jbiotec.2016.06.024	2016
	Evaluation of Yeast Alcohol Acetyltransferases for Ethyl Acetate Production in Clostridium ljungdahlii.	Boto ST, Gerges K, Bardl B, Rosenbaum MA.	Eng Life Sci	10.1002/elsc.202400076	2025
	Use of microbial indicators combined with environmental factors coupled with metrology tools for discrimination and classification of Luzhou-flavoured pit muds.	Zhang QY, Yuan YJ, Liao ZM, Zhang WX.	J Appl Microbiol	10.1111/jam.13544	2017
	Dynamic immobilization of bacterial cells on biofilm in a polyester nonwoven chemostat.	Zhang CL, Wang C, Dong YS, Sun YQ, Xiu ZL.	Bioresour Bioprocess	10.1186/s40643-024-00732-0	2024
	Enhanced chlorogenic acid production from glucose via systematic metabolic engineering of Saccharomyces cerevisiae.	Tu S, Wang J, Yang P, He Y, Gong Z, Zhong W.	Synth Syst Biotechnol	10.1016/j.synbio.2025.03.004	2025
	Multidimensional Optimization of Saccharomyces cerevisiae for Carotenoid Overproduction.	Fan J, Zhang Y, Li W, Li Z, Zhang D, Mo Q, Cao M, Yuan J.	Biodes Res	10.34133/bdr.0026	2024
	Performance and Emission Characteristics of a Small Gas Turbine Engine Using Hexanol as a Biomass-Derived Fuel.	Suchocki T.	Materials (Basel)	10.3390/ma17236011	2024
Genetics	Engineering Halomonas bluephagenesis TD01 for non-sterile production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate).	Chen X, Yin J, Ye J, Zhang H, Che X, Ma Y, Li M, Wu LP, Chen GQ.	Bioresour Technol	10.1016/j.biortech.2017.07.149	2017
	Evaluating the feasibility of medium-chain oleochemical synthesis using microbial chain elongation.	Agena E, Gois IM, Bowers CM, Mahadevan R, Scarborough MJ, Lawson CE.	J Ind Microbiol Biotechnol	10.1093/jimb/kuae027	2024
	Product Inhibition and pH Affect Stoichiometry and Kinetics of Chain Elongating Microbial Communities in Sequencing Batch Bioreactors.	Allaart MT, Stouten GR, Sousa DZ, Kleerebezem R.	Front Bioeng Biotechnol	10.3389/fbioe.2021.693030	2021
	Stratification of human gut microbiomes by succinotype is associated with inflammatory bowel disease status.	Anthamatten L, von Bieberstein PR, Menzi C, Zund JN, Lacroix C, de Wouters T, Leventhal GE.	Microbiome	10.1186/s40168-024-01897-8	2024
	Research progress on microbial adsorption of radioactive nuclides in deep geological environments.	Wang T, Zhang Q, Qiao Y, Jiang Y, Xiao F, Duan J, Zhao X.	Front Microbiol	10.3389/fmicb.2024.1430498	2024
Metabolism	Identification and quantification of the caproic acid-producing bacterium Clostridium kluyveri in the fermentation of pit mud used for Chinese strong-aroma type liquor production.	Hu XL, Du H, Xu Y.	Int J Food Microbiol	10.1016/j.ijfoodmicro.2015.07.032	2015
Metabolism	Optimum alcohol concentration for chain elongation in mixed-culture fermentation of cellulosic substrate.	Lonkar S, Fu Z, Holtzapple M.	Biotechnol Bioeng	10.1002/bit.26024	2016
Metabolism	Production of medium-chain volatile fatty acids by mixed ruminal microorganisms is enhanced by ethanol in co-culture with Clostridium kluyveri.	Weimer PJ, Nerdahl M, Brandl DJ.	Bioresour Technol	10.1016/j.biortech.2014.10.054	2015
	Influence of pH and temperature on the performance and microbial community during the production of medium-chain carboxylic acids using winery effluents as substrate.	Villegas-Rodriguez SB, Arreola-Vargas J, Buitron G.	Environ Sci Pollut Res Int	10.1007/s11356-024-33103-5	2025
Enzymology	A Coupled Ketoreductase-Diaphorase Assay for the Detection of Polyethylene Terephthalate-Hydrolyzing Activity.	Gimeno-Perez M, Finnigan JD, Echeverria C, Charnock SJ, Hidalgo A, Mate DM.	ChemSusChem	10.1002/cssc.202102750	2022
	Revealing the Characteristics of Glucose- and Lactate-Based Chain Elongation for Caproate Production by Caproicibacterium lactatifermentans through Transcriptomic, Bioenergetic, and Regulatory Analyses.	Wang H, Zhou W, Gao J, Ren C, Xu Y.	mSystems	10.1128/msystems.00534-22	2022
	The relationship between microbial diversity and the physicochemical characteristics of pit mud of Strong-flavor Baijiu	Zhu K, Xiao Q, Yuan S, Liu J, Shang H, Guo M, Zhao J.	Sci Rep		2025
	Quality Control Strategies for Pit Mud Based on the Synergistic Effects of Flavor, Microorganisms and Physicochemical Factors.	Sun L, Zhang X, Li X, Cao Z, Hui M, Pan C.	Foods	10.3390/foods14193326	2025
Enzymology	Isolated Diaphorase From Bovine Erythrocyte Cannot Reduce Oxidized Cytoglobin (Metcygb).	Novientri G, Sadikin M, Jusman SW.	Rep Biochem Mol Biol	10.52547/rbmb.11.2.289	2022
Enzymology	Enhancing the Substrate Specificity of Clostridium Succinyl-CoA Reductase for Synthetic Biology and Biocatalysis.	Pfister P, Diehl C, Hammarlund E, Carrillo M, Erb TJ.	Biochemistry	10.1021/acs.biochem.3c00102	2023
Enzymology	Kinetic mechanisms of electron bifurcation with electron transfer flavoprotein, NADH, butyryl-CoA dehydrogenase, and ferredoxin reveal a semiquinone cycle.	Sucharitakul J, Mangkalee M, Intasian P, Pornsuwan S, Ermler U, Buckel W, Chaiyen P.	J Biol Chem	10.1016/j.jbc.2025.110727	2025
	Thermodynamic and physiological study of caproate and 1,3-propanediol co-production through glycerol fermentation and fatty acids chain elongation.	Leng L, Yang P, Mao Y, Wu Z, Zhang T, Lee PH.	Water Res	10.1016/j.watres.2017.02.023	2017
	Clostridioides difficile utilizes siderophores as an iron source and FhuDBGC contributes to ferrichrome uptake.	Hastie JL, Carmichael HL, Werner BM, Dunbar KE, Carlson PE.	J Bacteriol	10.1128/jb.00324-23	2023
Metabolism	Impacts of ruminal microorganisms on the production of fuels: how can we intercede from the outside?	Weimer PJ, Kohn RA.	Appl Microbiol Biotechnol	10.1007/s00253-016-7358-2	2016
	Product Diversity Linked to Substrate Usage in Chain Elongation by Mixed-Culture Fermentation.	Coma M, Vilchez-Vargas R, Roume H, Jauregui R, Pieper DH, Rabaey K.	Environ Sci Technol	10.1021/acs.est.5b06021	2016
Enzymology	Spectroelectrochemical Enzyme Sensor System for Acetaldehyde Detection in Wine.	Ibanez D, Gonzalez-Garcia MB, Hernandez-Santos D, Fanjul-Bolado P.	Biosensors (Basel)	10.3390/bios12111032	2022
Metabolism	Acyl-CoA reductase PGN_0723 utilizes succinyl-CoA to generate succinate semialdehyde in a butyrate-producing pathway of Porphyromonas gingivalis.	Yoshida Y, Sato M, Kezuka Y, Hasegawa Y, Nagano K, Takebe J, Yoshimura F.	Arch Biochem Biophys	10.1016/j.abb.2016.03.014	2016
	Metabolic engineering of Saccharomyces cerevisiae for chelerythrine biosynthesis.	Zhu J, Zhang K, He Y, Zhang Q, Ran Y, Tan Z, Cui L, Feng Y.	Microb Cell Fact	10.1186/s12934-024-02448-4	2024
	Butyriproducens baijiuensis BJN0003: a potential new member of the family Oscillospiraceae isolated from Chinese Baijiu.	Wu M, Xu Y, Dai M, Li W, Zhang C, Li X, Sun B.	3 Biotech	10.1007/s13205-023-03624-w	2023
Metabolism	My Lifelong Passion for Biochemistry and Anaerobic Microorganisms.	Thauer RK.	Annu Rev Microbiol	10.1146/annurev-micro-091014-104344	2015
	Simultaneous Formate and Syngas Conversion Boosts Growth and Product Formation by Clostridium ragsdalei.	Schwarz I, Angelina A, Hambrock P, Weuster-Botz D.	Molecules	10.3390/molecules29112661	2024
Biotechnology	Methanol biotransformation toward high-level production of fatty acid derivatives by engineering the industrial yeast Pichia pastoris.	Cai P, Wu X, Deng J, Gao L, Shen Y, Yao L, Zhou YJ.	Proc Natl Acad Sci U S A	10.1073/pnas.2201711119	2022
	NovoLign: metaproteomics by sequence alignment.	Kleikamp HBC, van der Zwaan R, van Valderen R, van Ede JM, Pronk M, Schaasberg P, Allaart MT, van Loosdrecht MCM, Pabst M.	ISME Commun	10.1093/ismeco/ycae121	2024
	Modeling a co-culture of Clostridium autoethanogenum and Clostridium kluyveri to increase syngas conversion to medium-chain fatty-acids.	Benito-Vaquerizo S, Diender M, Parera Olm I, Martins Dos Santos VAP, Schaap PJ, Sousa DZ, Suarez-Diez M.	Comput Struct Biotechnol J	10.1016/j.csbj.2020.10.003	2020
	Minimal aromatic aldehyde reduction (MARE) yeast platform for engineering vanillin production.	Mo Q, Yuan J.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02454-5	2024
	Regulation on C2-C8 carboxylic acid biosynthesis from anaerobic CO₂ fermentation.	Wu W, Li Z, Liu G, Zhou L, Wang W.	Eng Life Sci	10.1002/elsc.202200069	2024
	Simple and Practical Multigram Synthesis of d-Xylonate Using a Recombinant Xylose Dehydrogenase.	Sanchez-Moreno I, Benito-Arenas R, Montero-Calle P, Hermida C, Garcia-Junceda E, Fernandez-Mayoralas A.	ACS Omega	10.1021/acsomega.9b01090	2019
	Microbial consortia for the conversion of biomass into fuels and chemicals.	Troiano DT, Studer MH.	Nat Commun	10.1038/s41467-025-61957-x	2025
	Cross-reactive CD8⁺ T cell responses to tumor-associated antigens (TAAs) and homologous microbiota-derived antigens (MoAs).	Cavalluzzo B, Viuff MC, Tvingsholm SA, Ragone C, Manolio C, Mauriello A, Buonaguro FM, Tornesello ML, Izzo F, Morabito A, Hadrup SR, Tagliamonte M, Buonaguro L.	J Exp Clin Cancer Res	10.1186/s13046-024-03004-z	2024
	Metabolic Engineering of Pichia pastoris for the Production of Triacetic Acid Lactone.	Feng L, Xu J, Ye C, Gao J, Huang L, Xu Z, Lian J.	J Fungi (Basel)	10.3390/jof9040494	2023
	The Influence of Hydrodynamic Conditions in a Laboratory-Scale Bioreactor on Pseudomonas aeruginosa Metabolite Production.	Konopacki M, Jablonska J, Dubrowska K, Augustyniak A, Grygorcewicz B, Glizniewicz M, Wroblewski E, Kordas M, Dolegowska B, Rakoczy R.	Microorganisms	10.3390/microorganisms11010088	2022
	Medium-chain carboxylates production from plant waste: kinetic study and effect of an enriched microbiome.	Undiandeye J, Gallegos D, Bonatelli ML, Kleinsteuber S, Bin-Hudari MS, Abdulkadir N, Stinner W, Strauber H.	Biotechnol Biofuels Bioprod	10.1186/s13068-024-02528-y	2024
Genetics	Genomic Analysis of Leptolyngbya boryana CZ1 Reveals Efficient Carbon Fixation Modules.	Bai X, Wang H, Cheng W, Wang J, Ma M, Hu H, Song Z, Ma H, Fan Y, Du C, Xu J.	Plants (Basel)	10.3390/plants12183251	2023
	Mixotrophic chain elongation with syngas and lactate as electron donors.	Baleeiro FCF, Raab J, Kleinsteuber S, Neumann A, Strauber H.	Microb Biotechnol	10.1111/1751-7915.14163	2023
	Optimizing hexanoic acid biosynthesis in Saccharomyces cerevisiae for the de novo production of olivetolic acid.	Schafer KJ, Aras M, Boles E, Kayser O.	Biotechnol Biofuels Bioprod	10.1186/s13068-024-02586-2	2024
Enzymology	Isolation, characterization, and quantification of Clostridium kluyveri from the bovine rumen.	Weimer PJ, Stevenson DM.	Appl Microbiol Biotechnol	10.1007/s00253-011-3751-z	2012
	Reconstruction and analyses of genome-scale halomonas metabolic network yield a highly efficient PHA production.	Zhang L, Sun X, Ye J, Yuan Q, Zhang X, Sun F, An Y, Chen Y, Qian Y, Yang D, Wang Q, Gao M, Chen T, Ma H, Chen G, Xie Z.	Metab Eng Commun	10.1016/j.mec.2024.e00251	2024
	Occurrence of genes encoding spore germination in Clostridium species that cause meat spoilage.	Burgess SA, Palevich FP, Gardner A, Mills J, Brightwell G, Palevich N.	Microb Genom	10.1099/mgen.0.000767	2022
	Production of (R)-citramalate by engineered Saccharomyces cerevisiae.	Mitsui R, Kondo A, Shirai T.	Metab Eng Commun	10.1016/j.mec.2024.e00247	2024
	Enrichment and characterisation of ethanol chain elongating communities from natural and engineered environments.	Candry P, Huang S, Carvajal-Arroyo JM, Rabaey K, Ganigue R.	Sci Rep	10.1038/s41598-020-60052-z	2020
	Extracellular mixed histones are neurotoxic and modulate select neuroimmune responses of glial cells.	Da Silva DE, Richards CM, McRae SA, Riar I, Yang SS, Zurfluh NE, Gibon J, Klegeris A.	PLoS One	10.1371/journal.pone.0298748	2024
	Bioinformatics and metabolic flux analysis highlight a new mechanism involved in lactate oxidation in Clostridium tyrobutyricum.	Munier E, Licandro H, Beuvier E, Cachon R.	Int Microbiol	10.1007/s10123-022-00316-y	2023
	Lactate-mediated mixotrophic co-cultivation of Clostridium drakei and recombinant Acetobacterium woodii for autotrophic production of volatile fatty acids.	Mook A, Herzog J, Walther P, Durre P, Bengelsdorf FR.	Microb Cell Fact	10.1186/s12934-024-02481-3	2024
	Lactate based caproate production with Clostridium drakei and process control of Acetobacterium woodii via lactate dependent in situ electrolysis.	Herzog J, Mook A, Utesch T, Bengelsdorf FR, Zeng AP.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1212044	2023
	Research trends on the gut microbiota in endocrine metabolism: a thematic and bibliometric analysis.	Dogan D, Celik T.	Front Cell Infect Microbiol	10.3389/fcimb.2024.1371727	2024
	In silico analysis of the alpha-amylase family GH57: eventual subfamilies reflecting enzyme specificities.	Martinovicova M, Janecek S.	3 Biotech	10.1007/s13205-018-1325-9	2018
Metabolism	Fatty acids production from hydrogen and carbon dioxide by mixed culture in the membrane biofilm reactor.	Zhang F, Ding J, Zhang Y, Chen M, Ding ZW, van Loosdrecht MC, Zeng RJ.	Water Res	10.1016/j.watres.2013.07.033	2013
Enzymology	A distinct class of ferredoxin:NADP⁺ oxidoreductase enzymes driving thermophilic ethanol production.	Huang S, Saad Imran SM, Lanahan AA, Hammer SK, Lubner CE, Lynd LR, Olson DG.	J Biol Chem	10.1016/j.jbc.2025.110263	2025
	Medium-Chain Fatty Acids and Breast Cancer Risk by Receptor and Pathological Subtypes.	Roopashree PG, Shetty SS, Shetty VV, Nalilu SK.	Nutrients	10.3390/nu14245351	2022
	Alternative sources of molybdenum for Methanococcus maripaludis and their implication for the evolution of molybdoenzymes.	Payne D, Keller LM, Larson J, Bothner B, Colman DR, Boyd ES.	Commun Biol	10.1038/s42003-024-07049-w	2024
Genetics	Biosynthesis mechanisms of medium-chain carboxylic acids and alcohols in anaerobic microalgae fermentation regulated by pH conditions.	Shi X, Wei W, Wu L, Huang Y, Ni B-J.	Appl Environ Microbiol	10.1128/aem.01250-23	2024
Transcriptome	The Colorectal Cancer Gut Environment Regulates Activity of the Microbiome and Promotes the Multidrug Resistant Phenotype of ESKAPE and Other Pathogens.	Lamaudiere MTF, Arasaradnam R, Weedall GD, Morozov IY.	mSphere	10.1128/msphere.00626-22	2023
	Regulation of the phagocytic activity of astrocytes by neuroimmune mediators endogenous to the central nervous system.	Yang SS, Simtchouk S, Gibon J, Klegeris A.	PLoS One	10.1371/journal.pone.0289169	2023
	Biomass-specific rates as key performance indicators: A nitrogen balancing method for biofilm-based electrochemical conversion.	Winkelhorst M, Cabau-Peinado O, Straathof AJJ, Jourdin L.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1096086	2023
	Ecology of food waste chain-elongating microbiome.	Crognale S, Massimi A, Sbicego M, Braguglia CM, Gallipoli A, Gazzola G, Gianico A, Tonanzi B, Di Pippo F, Rossetti S.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1157243	2023
	Biosynthesis of butyrate from methanol and carbon monoxide by recombinant Acetobacterium woodii.	Chowdhury NP, Litty D, Muller V.	Int Microbiol	10.1007/s10123-022-00234-z	2022
Metabolism	A novel high-throughput method for kinetic characterisation of anaerobic bioproduction strains, applied to Clostridium kluyveri.	Candry P, Van Daele T, Denis K, Amerlinck Y, Andersen SJ, Ganigue R, Arends JBA, Nopens I, Rabaey K.	Sci Rep	10.1038/s41598-018-27594-9	2018
	N-methyl-bacillithiol, a Novel Thiol from Anaerobic Bacteria.	Newton GL, Rawat M.	mBio	10.1128/mbio.02634-18	2019
Metabolism	Structure of a trimeric bacterial microcompartment shell protein, EtuB, associated with ethanol utilization in Clostridium kluyveri.	Heldt D, Frank S, Seyedarabi A, Ladikis D, Parsons JB, Warren MJ, Pickersgill RW.	Biochem J	10.1042/bj20090780	2009
	Low-Cost Clamp-On Photometers (ClampOD) and Tube Photometers (TubeOD) for Online Cell Density Determination.	Deutzmann JS, Callander G, Gu W, Muller AL, McCully AL, Ahn JK, Kracke F, Spormann AM.	Front Microbiol	10.3389/fmicb.2021.790576	2021
	New Insights into the Physiology of the Propionate Producers Anaerotignum propionicum and Anaerotignum neopropionicum (Formerly Clostridium propionicum and Clostridium neopropionicum).	Baur T, Durre P.	Microorganisms	10.3390/microorganisms11030685	2023
Metabolism	Production and characterization of poly(3-hydroxypropionate-co-4-hydroxybutyrate) with fully controllable structures by recombinant Escherichia coli containing an engineered pathway.	Meng DC, Shi ZY, Wu LP, Zhou Q, Wu Q, Chen JC, Chen GQ.	Metab Eng	10.1016/j.ymben.2012.04.003	2012
Metabolism	Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) from unrelated carbon sources by metabolically engineered Escherichia coli.	Li ZJ, Shi ZY, Jian J, Guo YY, Wu Q, Chen GQ.	Metab Eng	10.1016/j.ymben.2010.03.003	2010
	Microbial biogeography of pit mud from an artificial brewing ecosystem on a large time scale: all roads lead to Rome.	Mei J-L, Chai L-J, Zhong X-Z, Lu Z-M, Zhang X-J, Wang S-T, Shen C-H, Shi J-S, Xu Z-H.	mSystems	10.1128/msystems.00564-23	2023
Phylogeny	Isolation and characterization of novel acetogenic Moorella strains for employment as potential thermophilic biocatalysts.	Boer T, Engelhardt L, Luschen A, Eysell L, Yoshida H, Schneider D, Angenent LT, Basen M, Daniel R, Poehlein A.	FEMS Microbiol Ecol	10.1093/femsec/fiae109	2024
Metabolism	Characterization of a dihydrolipoyl dehydrogenase having diaphorase activity of Clostridium kluyveri.	Chakraborty S, Sakka M, Kimura T, Sakka K.	Biosci Biotechnol Biochem	10.1271/bbb.70724	2008
Metabolism	Butyryl/Caproyl-CoA:Acetate CoA-transferase: cloning, expression and characterization of the key enzyme involved in medium-chain fatty acid biosynthesis.	Yang Q, Guo S, Lu Q, Tao Y, Zheng D, Zhou Q, Liu J.	Biosci Rep	10.1042/bsr20211135	2021
Metabolism	Metabolic Interactions of a Chain Elongation Microbiome.	Han W, He P, Shao L, Lu F.	Appl Environ Microbiol	10.1128/aem.01614-18	2018
	Improvement of caproic acid production in a Clostridium kluyveri H068 and Methanogen 166 co-culture fermentation system.	Yan S, Dong D.	AMB Express	10.1186/s13568-018-0705-1	2018
	Cloning and expression of a Clostridium kluyveri gene responsible for diaphorase activity.	Chakraborty S, Sakka M, Kimura T, Sakka K.	Biosci Biotechnol Biochem	10.1271/bbb.70606	2008
	Electricity-assisted production of caproic acid from grass.	Khor WC, Andersen S, Vervaeren H, Rabaey K.	Biotechnol Biofuels	10.1186/s13068-017-0863-4	2017
Metabolism	Caproate formation in mixed-culture fermentative hydrogen production.	Ding HB, Tan GY, Wang JY.	Bioresour Technol	10.1016/j.biortech.2010.07.056	2010
	Metabolic modeling of bacterial co-culture systems predicts enhanced carbon monoxide-to-butyrate conversion compared to monoculture systems.	Li X, Henson MA.	Biochem Eng J	10.1016/j.bej.2019.107338	2019
Genetics	The Space-Exposed Kombucha Microbial Community Member Komagataeibacter oboediens Showed Only Minor Changes in Its Genome After Reactivation on Earth.	Santana de Carvalho D, Trovatti Uetanabaro AP, Kato RB, Aburjaile FF, Jaiswal AK, Profeta R, De Oliveira Carvalho RD, Tiwar S, Cybelle Pinto Gomide A, Almeida Costa E, Kukharenko O, Orlovska I, Podolich O, Reva O, Ramos PIP, De Carvalho Azevedo VA, Brenig B, Andrade BS, de Vera JP, Kozyrovska NO, Barh D, Goes-Neto A.	Front Microbiol	10.3389/fmicb.2022.782175	2022
Transcriptome	Metabolite-Based Mutualistic Interaction between Two Novel Clostridial Species from Pit Mud Enhances Butyrate and Caproate Production.	Sun H, Chai LJ, Fang GY, Lu ZM, Zhang XJ, Wang ST, Shen CH, Shi JS, Xu ZH.	Appl Environ Microbiol	10.1128/aem.00484-22	2022
Enzymology	Syngas Fermentation for the Production of Bio-Based Polymers: A Review.	Dhakal N, Acharya B.	Polymers (Basel)	10.3390/polym13223917	2021
Metabolism	Cell factories converting lactate and acetate to butyrate: Clostridium butyricum and microbial communities from dark fermentation bioreactors.	Detman A, Mielecki D, Chojnacka A, Salamon A, Blaszczyk MK, Sikora A.	Microb Cell Fact	10.1186/s12934-019-1085-1	2019
	Characterizing the interaction relationship of the microbial communities between Zaopei and pit mud disturbing by Daqu.	Chen S, Huang J, Qin H, Zhou R, Yang Y, Qiu C, Zhang S.	Food Sci Biotechnol	10.1007/s10068-021-00975-z	2021
	Increased CO₂ fixation enables high carbon-yield production of 3-hydroxypropionic acid in yeast.	Qin N, Li L, Wan X, Ji X, Chen Y, Li C, Liu P, Zhang Y, Yang W, Jiang J, Xia J, Shi S, Tan T, Nielsen J, Chen Y, Liu Z.	Nat Commun	10.1038/s41467-024-45557-9	2024
	Open Culture Ethanol-Based Chain Elongation to Form Medium Chain Branched Carboxylates and Alcohols.	de Leeuw KD, Ahrens T, Buisman CJN, Strik DPBTB.	Front Bioeng Biotechnol	10.3389/fbioe.2021.697439	2021
Metabolism	An Efficient New Process for the Selective Production of Odd-Chain Carboxylic Acids by Simple Carbon Elongation Using Megasphaera hexanoica.	Kim H, Jeon BS, Sang BI.	Sci Rep	10.1038/s41598-019-48591-6	2019
	Formate-induced CO tolerance and methanogenesis inhibition in fermentation of syngas and plant biomass for carboxylate production.	Baleeiro FCF, Varchmin L, Kleinsteuber S, Strauber H, Neumann A.	Biotechnol Biofuels Bioprod	10.1186/s13068-023-02271-w	2023
Pathogenicity	Colonic Medium-Chain Fatty Acids Act as a Source of Energy and for Colon Maintenance but Are Not Utilized to Acylate Ghrelin.	Gregor A, Auernigg-Haselmaier S, Trajanoski S, Konig J, Duszka K.	Nutrients	10.3390/nu13113807	2021
Metabolism	Expressing a cytosolic pyruvate dehydrogenase complex to increase free fatty acid production in Saccharomyces cerevisiae.	Zhang Y, Su M, Qin N, Nielsen J, Liu Z.	Microb Cell Fact	10.1186/s12934-020-01493-z	2020
	Refining and illuminating acetogenic Eubacterium strains for reclassification and metabolic engineering.	Flaiz M, Poehlein A, Wilhelm W, Mook A, Daniel R, Durre P, Bengelsdorf FR.	Microb Cell Fact	10.1186/s12934-024-02301-8	2024
	Why do lactic acid bacteria thrive in chain elongation microbiomes?	Ulcar B, Regueira A, Podojstersek M, Boon N, Ganigue R.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1291007	2023
	MCPdb: The bacterial microcompartment database.	Ochoa JM, Bair K, Holton T, Bobik TA, Yeates TO.	PLoS One	10.1371/journal.pone.0248269	2021
	Molecular architecture and electron transfer pathway of the Stn family transhydrogenase.	Kumar A, Kremp F, Roth J, Freibert SA, Muller V, Schuller JM.	Nat Commun	10.1038/s41467-023-41212-x	2023
Metabolism	A modular pathway engineering strategy for the high-level production of beta-ionone in Yarrowia lipolytica.	Lu Y, Yang Q, Lin Z, Yang X.	Microb Cell Fact	10.1186/s12934-020-01309-0	2020
	One-step production of C6-C8 carboxylates by mixed culture solely grown on CO.	He P, Han W, Shao L, Lu F.	Biotechnol Biofuels	10.1186/s13068-017-1005-8	2018
	Enzyme-Activated, Chemiluminescent Siderophore-Dioxetane Probes Enable the Selective and Highly Sensitive Detection of Bacterial Pathogens.	Peukert C, Popat Gholap S, Green O, Pinkert L, van den Heuvel J, van Ham M, Shabat D, Bronstrup M.	Angew Chem Int Ed Engl	10.1002/anie.202201423	2022
Metabolism	Stereo-specificity for pro-(R) hydrogen of NAD(P)H during enzyme-catalyzed hydride transfer to CL-20.	Bhushan B, Halasz A, Hawari J.	Biochem Biophys Res Commun	10.1016/j.bbrc.2005.09.166	2005
	Exploring alternative pathways for the in vitro establishment of the HOPAC cycle for synthetic CO₂ fixation.	McLean R, Schwander T, Diehl C, Cortina NS, Paczia N, Zarzycki J, Erb TJ.	Sci Adv	10.1126/sciadv.adh4299	2023
	Hydrologic Alteration and Enhanced Microbial Reductive Dissolution of Fe(III) (hydr)oxides Under Flow Conditions in Fe(III)-Rich Rocks: Contribution to Cave-Forming Processes.	Calapa KA, Mulford MK, Rieman TD, Senko JM, Auler AS, Parker CW, Barton HA.	Front Microbiol	10.3389/fmicb.2021.696534	2021
	A Narrow pH Range Supports Butanol, Hexanol, and Octanol Production from Syngas in a Continuous Co-culture of Clostridium ljungdahlii and Clostridium kluyveri with In-Line Product Extraction.	Richter H, Molitor B, Diender M, Sousa DZ, Angenent LT.	Front Microbiol	10.3389/fmicb.2016.01773	2016
	Molecular characterization of the missing electron pathways for butanol synthesis in Clostridium acetobutylicum.	Foulquier C, Riviere A, Heulot M, Dos Reis S, Perdu C, Girbal L, Pinault M, Dusseaux S, Yoo M, Soucaille P, Meynial-Salles I.	Nat Commun	10.1038/s41467-022-32269-1	2022
	Enhanced Ethanol Production From Carbon Monoxide by Enriched Clostridium Bacteria.	He Y, Lens PNL, Veiga MC, Kennes C.	Front Microbiol	10.3389/fmicb.2021.754713	2021
	Tuning Fatty Acid Profile and Yield in Pichia pastoris.	Kobalter S, Voit A, Bekerle-Bogner M, Rudalija H, Haas A, Wriessnegger T, Pichler H.	Bioengineering (Basel)	10.3390/bioengineering10121412	2023
Genetics	Genome-Scale Metabolic Network Reconstruction and In Silico Analysis of Hexanoic acid Producing Megasphaera elsdenii.	Lee NR, Lee CH, Lee DY, Park JB.	Microorganisms	10.3390/microorganisms8040539	2020
Genetics	Comparison of metagenomes from fermentation of various agroindustrial residues suggests a common model of community organization.	Myers KS, Ingle AT, Walters KA, Fortney NW, Scarborough MJ, Donohue TJ, Noguera DR.	Front Bioeng Biotechnol	10.3389/fbioe.2023.1197175	2023
Metabolism	Metabolic properties of Eubacterium pyruvativorans, a ruminal 'hyper-ammonia-producing' anaerobe with metabolic properties analogous to those of Clostridium kluyveri.	Wallace RJ, Chaudhary LC, Miyagawa E, McKain N, Walker ND.	Microbiology (Reading)	10.1099/mic.0.27190-0	2004
Transcriptome	Antifungal mechanism of Bacillus amyloliquefaciens strain GKT04 against Fusarium wilt revealed using genomic and transcriptomic analyses.	Tian D, Song X, Li C, Zhou W, Qin L, Wei L, Di W, Huang S, Li B, Huang Q, Long S, He Z, Wei S.	Microbiologyopen	10.1002/mbo3.1192	2021
	Production of biofuels from C₁ -gases with Clostridium and related bacteria-Recent advances.	Fernandez-Blanco C, Robles-Iglesias R, Naveira-Pazos C, Veiga MC, Kennes C.	Microb Biotechnol	10.1111/1751-7915.14220	2023
	Application of a Portable Multi-Analyte Biosensor for Organic Acid Determination in Silage.	Pilas J, Yazici Y, Selmer T, Keusgen M, Schoning MJ.	Sensors (Basel)	10.3390/s18051470	2018
	Low Fermentation pH Is a Trigger to Alcohol Production, but a Killer to Chain Elongation.	Ganigue R, Sanchez-Paredes P, Baneras L, Colprim J.	Front Microbiol	10.3389/fmicb.2016.00702	2016
	Extended conformations of bifurcating electron transfer flavoprotein constitute up to half the population, possibly mediating conformational change.	Khan SA, Hicks A, Leite WC, Byrnes J, Gorai B, Mroginski MA, O'Neill H, Miller AF.	Chem Sci	10.1039/d4sc04544k	2024
Metabolism	The Serine Biosynthesis of Paenibacillus polymyxa WLY78 Is Regulated by the T-Box Riboswitch.	Zhang H, Li Q, Li Y, Chen S.	Int J Mol Sci	10.3390/ijms22063033	2021
Enzymology	(S)-3-Hydroxybutyryl-CoA Dehydrogenase From the Autotrophic 3-Hydroxypropionate/4-Hydroxybutyrate Cycle in Nitrosopumilus maritimus.	Liu L, Schubert DM, Konneke M, Berg IA.	Front Microbiol	10.3389/fmicb.2021.712030	2021
Enzymology	Molecular Basis of the Electron Bifurcation Mechanism in the [FeFe]-Hydrogenase Complex HydABC.	Katsyv A, Kumar A, Saura P, Poverlein MC, Freibert SA, T Stripp S, Jain S, Gamiz-Hernandez AP, Kaila VRI, Muller V, Schuller JM.	J Am Chem Soc	10.1021/jacs.2c11683	2023
Enzymology	Acetate:succinate CoA-transferase in the hydrogenosomes of Trichomonas vaginalis: identification and characterization.	van Grinsven KWA, Rosnowsky S, van Weelden SWH, Putz S, van der Giezen M, Martin W, van Hellemond JJ, Tielens AGM, Henze K.	J Biol Chem	10.1074/jbc.m702528200	2008
Metabolism	[Construction of recombinant Escherichia coli strains producing poly (4-hydroxybutyric acid) homopolyester from glucose].	Song SS, Ma H, Gao ZX, Jia ZH, Zhang X.	Wei Sheng Wu Xue Bao		2005
Genetics	Genomic Insights into the Ecological Role and Evolution of a Novel Thermoplasmata Order, "Candidatus Sysuiplasmatales".	Yuan Y, Liu J, Yang TT, Gao SM, Liao B, Huang LN.	Appl Environ Microbiol	10.1128/aem.01065-21	2021
Metabolism	Detection of pyroptosis by measuring released lactate dehydrogenase activity.	Rayamajhi M, Zhang Y, Miao EA.	Methods Mol Biol	10.1007/978-1-62703-523-1_7	2013
Genetics	Novel endolithic bacteria of phylum Chloroflexota reveal a myriad of potential survival strategies in the Antarctic desert.	Williams TJ, Allen MA, Ray AE, Benaud N, Chelliah DS, Albanese D, Donati C, Selbmann L, Coleine C, Ferrari BC.	Appl Environ Microbiol	10.1128/aem.02264-23	2024
Metabolism	De novo design of signal sequences to localize cargo to the 1,2-propanediol utilization microcompartment.	Jakobson CM, Slininger Lee MF, Tullman-Ercek D.	Protein Sci	10.1002/pro.3144	2017
	Establishing Butyribacterium methylotrophicum as a Platform Organism for the Production of Biocommodities from Liquid C₁ Metabolites.	Humphreys JR, Hebdon SD, Rohrer H, Magnusson L, Urban C, Chen YP, Lo J.	Appl Environ Microbiol	10.1128/aem.02393-21	2022
	Model-driven approach for the production of butyrate from CO₂/H₂ by a novel co-culture of C. autoethanogenum and C. beijerinckii.	Benito-Vaquerizo S, Nouse N, Schaap PJ, Hugenholtz J, Brul S, Lopez-Contreras AM, Martins Dos Santos VAP, Suarez-Diez M.	Front Microbiol	10.3389/fmicb.2022.1064013	2022
Metabolism	Key sub-community dynamics of medium-chain carboxylate production.	Lambrecht J, Cichocki N, Schattenberg F, Kleinsteuber S, Harms H, Muller S, Strauber H.	Microb Cell Fact	10.1186/s12934-019-1143-8	2019
Metabolism	Genome-scale metabolic modelling enables deciphering ethanol metabolism via the acrylate pathway in the propionate-producer Anaerotignum neopropionicum.	Benito-Vaquerizo S, Parera Olm I, de Vroet T, Schaap PJ, Sousa DZ, Martins Dos Santos VAP, Suarez-Diez M.	Microb Cell Fact	10.1186/s12934-022-01841-1	2022
Metabolism	Diaphorase Coupling Protocols for Red-Shifting Dehydrogenase Assays.	Davis MI, Shen M, Simeonov A, Hall MD.	Assay Drug Dev Technol	10.1089/adt.2016.706	2016
Metabolism	Increasing lipid yield in Yarrowia lipolytica through phosphoketolase and phosphotransacetylase expression in a phosphofructokinase deletion strain.	Kamineni A, Consiglio AL, MacEwen K, Chen S, Chifamba G, Shaw AJ, Tsakraklides V.	Biotechnol Biofuels	10.1186/s13068-021-01962-6	2021
	Omics Metadata Management Software (OMMS).	Perez-Arriaga MO, Wilson S, Williams KP, Schoeniger J, Waymire RL, Powell AJ.	Bioinformation	10.6026/97320630011165	2015
Metabolism	Hyperproduction of poly(4-hydroxybutyrate) from glucose by recombinant Escherichia coli.	Zhou XY, Yuan XX, Shi ZY, Meng DC, Jiang WJ, Wu LP, Chen JC, Chen GQ.	Microb Cell Fact	10.1186/1475-2859-11-54	2012
Genetics	Direct Conversion of Food Waste Extract into Caproate: Metagenomics Assessment of Chain Elongation Process.	Crognale S, Braguglia CM, Gallipoli A, Gianico A, Rossetti S, Montecchio D.	Microorganisms	10.3390/microorganisms9020327	2021
Metabolism	A Pan-Genome Guided Metabolic Network Reconstruction of Five Propionibacterium Species Reveals Extensive Metabolic Diversity.	McCubbin T, Gonzalez-Garcia RA, Palfreyman RW, Stowers C, Nielsen LK, Marcellin E.	Genes (Basel)	10.3390/genes11101115	2020
	Effect of Endogenous and Exogenous Butyric Acid on Butanol Production From CO by Enriched Clostridia.	He Y, Lens PNL, Veiga MC, Kennes C.	Front Bioeng Biotechnol	10.3389/fbioe.2022.828316	2022
	Biological Parts for Plant Biodesign to Enhance Land-Based Carbon Dioxide Removal.	Yang X, Liu D, Lu H, Weston DJ, Chen JG, Muchero W, Martin S, Liu Y, Hassan MM, Yuan G, Kalluri UC, Tschaplinski TJ, Mitchell JC, Wullschleger SD, Tuskan GA.	Biodes Res	10.34133/2021/9798714	2021
	Exo-Metabolites of Phaseolus vulgaris-Nodulating Rhizobial Strains.	Montes-Grajales D, Esturau-Escofet N, Esquivel B, Martinez-Romero E.	Metabolites	10.3390/metabo9060105	2019
Enzymology	Mining the Factors Driving the Evolution of the Pit Mud Microbiome under the Impact of Long-Term Production of Strong-Flavor Baijiu.	Chai LJ, Qian W, Zhong XZ, Zhang XJ, Lu ZM, Zhang SY, Wang ST, Shen CH, Shi JS, Xu ZH.	Appl Environ Microbiol	10.1128/aem.00885-21	2021
Phylogeny	Illuminating Anaerobic Microbial Community and Cooccurrence Patterns across a Quality Gradient in Chinese Liquor Fermentation Pit Muds.	Hu X, Du H, Ren C, Xu Y.	Appl Environ Microbiol	10.1128/aem.03409-15	2016
	A novel anti-dipteran Bacillus thuringiensis strain: Unusual Cry toxin genes in a highly dynamic plasmid environment.	Fayad N, Kambris Z, El Chamy L, Mahillon J, Kallassy Awad M.	Appl Environ Microbiol	10.1128/aem.02294-20	2021
Enzymology	Recombinant expression, characterization and application of a dihydrolipoamide dehydrogenase with diaphorase activity from Bacillus sphaericus.	Kianmehr A, Mahdizadeh R, Oladnabi M, Ansari J.	3 Biotech	10.1007/s13205-017-0763-0	2017
Metabolism	Propionate Production from Carbon Monoxide by Synthetic Cocultures of Acetobacterium wieringae and Propionigenic Bacteria.	Moreira JPC, Diender M, Arantes AL, Boeren S, Stams AJM, Alves MM, Alves JI, Sousa DZ.	Appl Environ Microbiol	10.1128/aem.02839-20	2021
	Compact analytical flow system for the simultaneous determination of L-lactic and L-malic in red wines.	Gimenez-Gomez P, Gutierrez-Capitan M, Capdevila F, Puig-Pujol A, Jimenez-Jorquera C, Fernandez-Sanchez C.	Sci Rep	10.1038/s41598-020-76502-7	2020
	Enrichment of Anaerobic Syngas-Converting Communities and Isolation of a Novel Carboxydotrophic Acetobacterium wieringae Strain JM.	Arantes AL, Moreira JPC, Diender M, Parshina SN, Stams AJM, Alves MM, Alves JI, Sousa DZ.	Front Microbiol	10.3389/fmicb.2020.00058	2020
	A novel glycosidase plate-based assay for the quantification of galactosylation and sialylation on human IgG.	Rebello OD, Gardner RA, Urbanowicz PA, Bolam DN, Crouch LI, Falck D, Spencer DIR.	Glycoconj J	10.1007/s10719-020-09953-9	2020
Metabolism	Lipoyl dehydrogenase catalyzes reduction of nitrated DNA and protein adducts using dihydrolipoic acid or ubiquinol as the cofactor.	Chen HJ, Chen YM, Chang CM.	Chem Biol Interact	10.1016/s0009-2797(02)00019-4	2002
	Genetic Evidence Reveals the Indispensable Role of the rseC Gene for Autotrophy and the Importance of a Functional Electron Balance for Nitrate Reduction in Clostridium ljungdahlii.	Klask CM, Jager B, Casini I, Angenent LT, Molitor B.	Front Microbiol	10.3389/fmicb.2022.887578	2022
Metabolism	Diaphorase catalyzed biotransformation of RDX via N-denitration mechanism.	Bhushan B, Halasz A, Spain JC, Hawari J.	Biochem Biophys Res Commun	10.1016/s0006-291x(02)00874-4	2002
	Reproducible, high-yielding, biological caproate production from food waste using a single-phase anaerobic reactor system.	Nzeteu CO, Trego AC, Abram F, O'Flaherty V.	Biotechnol Biofuels	10.1186/s13068-018-1101-4	2018
	NADH-Mediated Gene Expression in Streptococcus pneumoniae and Role of Rex as a Transcriptional Repressor of the Rex-Regulon.	Afzal M, Shafeeq S, Kuipers OP.	Front Microbiol	10.3389/fmicb.2018.01300	2018
Metabolism	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals.	Liu Q, Yu T, Li X, Chen Y, Campbell K, Nielsen J, Chen Y.	Nat Commun	10.1038/s41467-019-12961-5	2019
	Enzymatic assay of dehydrogenase substrate based on the detection of superoxide anion	Sarker AK, Ukeda H, Kawana D, Sawamura M.	Food Res Int	10.1016/s0963-9969(00)00183-6	2001
	Hydrogen as a Co-electron Donor for Chain Elongation With Complex Communities.	Baleeiro FCF, Kleinsteuber S, Strauber H.	Front Bioeng Biotechnol	10.3389/fbioe.2021.650631	2021
	Distribution, Evolution, Catalytic Mechanism, and Physiological Functions of the Flavin-Based Electron-Bifurcating NADH-Dependent Reduced Ferredoxin: NADP⁺ Oxidoreductase.	Liang J, Huang H, Wang S.	Front Microbiol	10.3389/fmicb.2019.00373	2019
Metabolism	Identification of Activators of Human Fumarate Hydratase by Quantitative High-Throughput Screening.	Zhu H, Lee OW, Shah P, Jadhav A, Xu X, Patnaik S, Shen M, Hall MD.	SLAS Discov	10.1177/2472555219873559	2020
	The Isolate Caproiciproducens sp. 7D4C2 Produces n-Caproate at Mildly Acidic Conditions From Hexoses: Genome and rBOX Comparison With Related Strains and Chain-Elongating Bacteria.	Esquivel-Elizondo S, Bagci C, Temovska M, Jeon BS, Bessarab I, Williams RBH, Huson DH, Angenent LT.	Front Microbiol	10.3389/fmicb.2020.594524	2020
	Identification of Multiple Soluble Fe(III) Reductases in Gram-Positive Thermophilic Bacterium Thermoanaerobacter indiensis BSB-33.	Pal S.	Int J Genomics	10.1155/2014/850607	2014
	Short-chain fatty acids promote the effect of environmental signals on the gut microbiome and metabolome in mice.	Marrocco F, Delli Carpini M, Garofalo S, Giampaoli O, De Felice E, Di Castro MA, Maggi L, Scavizzi F, Raspa M, Marini F, Tomassini A, Nicolosi R, Cason C, Trettel F, Miccheli A, Iebba V, D'Alessandro G, Limatola C.	Commun Biol	10.1038/s42003-022-03468-9	2022
Metabolism	Two pathways for glutamate biosynthesis in the syntrophic bacterium Syntrophus aciditrophicus.	Kim M, Le HM, Xie X, Feng X, Tang YJ, Mouttaki H, McInerney MJ, Buckel W.	Appl Environ Microbiol	10.1128/aem.02323-15	2015
Metabolism	Proteome adaptations of the organohalide-respiring Desulfitobacterium hafniense strain DCB-2 to various energy metabolisms.	Willemin MS, Hamelin R, Armand F, Holliger C, Maillard J.	Front Microbiol	10.3389/fmicb.2023.1058127	2023
Metabolism	Improvement of n-caproic acid production with Ruminococcaceae bacterium CPB6: selection of electron acceptors and carbon sources and optimization of the culture medium.	Wang H, Li X, Wang Y, Tao Y, Lu S, Zhu X, Li D.	Microb Cell Fact	10.1186/s12934-018-0946-3	2018
Enzymology	The effect of 3-nitrooxypropanol, a potent methane inhibitor, on ruminal microbial gene expression profiles in dairy cows.	Pitta DW, Indugu N, Melgar A, Hristov A, Challa K, Vecchiarelli B, Hennessy M, Narayan K, Duval S, Kindermann M, Walker N.	Microbiome	10.1186/s40168-022-01341-9	2022
Metabolism	Fermentation of 4-aminobutyrate by Clostridium aminobutyricum: cloning of two genes involved in the formation and dehydration of 4-hydroxybutyryl-CoA.	Gerhardt A, Cinkaya I, Linder D, Huisman G, Buckel W.	Arch Microbiol	10.1007/s002030000195	2000
Metabolism	Poly(3-hydroxybutyrate-co-4-hydroxybutyrate) formation from gamma-aminobutyrate and glutamate.	Valentin HE, Reiser S, Gruys KJ.	Biotechnol Bioeng	10.1002/(sici)1097-0290(20000205)67:3<291::aid-bit5>3.0.co;2-j	2000
	Parameters influencing the development of highly conductive and efficient biofilm during microbial electrosynthesis: the importance of applied potential and inorganic carbon source.	Izadi P, Fontmorin JM, Godain A, Yu EH, Head IM.	NPJ Biofilms Microbiomes	10.1038/s41522-020-00151-x	2020
	Autotrophic and mixotrophic metabolism of an anammox bacterium revealed by in vivo ¹³C and ²H metabolic network mapping.	Lawson CE, Nuijten GHL, de Graaf RM, Jacobson TB, Pabst M, Stevenson DM, Jetten MSM, Noguera DR, McMahon KD, Amador-Noguez D, Lucker S.	ISME J	10.1038/s41396-020-00805-w	2021
Metabolism	Production of caproic acid by cocultures of ruminal cellulolytic bacteria and Clostridium kluyveri grown on cellulose and ethanol.	Kenealy WR, Cao Y, Weimer PJ.	Appl Microbiol Biotechnol	10.1007/s002530050590	1995
	Water Networks and Correlated Motions in Mutant Isocitrate Dehydrogenase 1 (IDH1) Are Critical for Allosteric Inhibitor Binding and Activity.	Chambers JM, Miller W, Quichocho G, Upadhye V, Matteo DA, Bobkov AA, Sohl CD, Schiffer JM.	Biochemistry	10.1021/acs.biochem.9b01023	2020
	Electrolytic extraction drives volatile fatty acid chain elongation through lactic acid and replaces chemical pH control in thin stillage fermentation.	Andersen SJ, Candry P, Basadre T, Khor WC, Roume H, Hernandez-Sanabria E, Coma M, Rabaey K.	Biotechnol Biofuels	10.1186/s13068-015-0396-7	2015
Metabolism	Production of poly(3-hydroxybutyrate-co-4-hydroxybutyrate) in recombinant Escherichia coli grown on glucose.	Valentin HE, Dennis D.	J Biotechnol	10.1016/s0168-1656(97)00127-2	1997
Enzymology	Purification and characterization of the oxygen-sensitive 4-hydroxybutanoate dehydrogenase from Clostridium kluyveri.	Wolff RA, Kenealy WR.	Protein Expr Purif	10.1006/prep.1995.1026	1995
Metabolism	Distinct N and C Cross-Feeding Networks in a Synthetic Mouse Gut Consortium.	Perez Escriva P, Fuhrer T, Sauer U.	mSystems	10.1128/msystems.01484-21	2022
	Antihyperglycemic effects of Pandanus amaryllifolius Roxb. leaf extract.	Chiabchalard A, Nooron N.	Pharmacogn Mag	10.4103/0973-1296.149724	2015
	Branched Medium Chain Fatty Acids: Iso-Caproate Formation from Iso-Butyrate Broadens the Product Spectrum for Microbial Chain Elongation.	de Leeuw KD, Buisman CJN, Strik DPBTB.	Environ Sci Technol	10.1021/acs.est.8b07256	2019
Metabolism	Modeling Growth Kinetics, Interspecies Cell Fusion, and Metabolism of a Clostridium acetobutylicum/Clostridium ljungdahlii Syntrophic Coculture.	Foster C, Charubin K, Papoutsakis ET, Maranas CD.	mSystems	10.1128/msystems.01325-20	2021
	Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors.	Rohde JM, Brimacombe KR, Liu L, Pacold ME, Yasgar A, Cheff DM, Lee TD, Rai G, Baljinnyam B, Li Z, Simeonov A, Hall MD, Shen M, Sabatini DM, Boxer MB.	Bioorg Med Chem	10.1016/j.bmc.2018.02.016	2018
	Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography.	Palma-Chavez JA, Kim W, Serafino M, Jo JA, Charoenphol P, Applegate BE.	Biomed Opt Express	10.1364/boe.399322	2020
Phylogeny	Re-citrate synthase from Clostridium kluyveri is phylogenetically related to homocitrate synthase and isopropylmalate synthase rather than to Si-citrate synthase.	Li F, Hagemeier CH, Seedorf H, Gottschalk G, Thauer RK.	J Bacteriol	10.1128/jb.00198-07	2007
	Design of Flow Systems for Improved Networking and Reduced Noise in Biomolecular Signal Processing in Biocomputing and Biosensing Applications.	Verma A, Fratto BE, Privman V, Katz E.	Sensors (Basel)	10.3390/s16071042	2016
Metabolism	Production of OH-radical-type oxidant by lucigenin.	Heiser I, Muhr A, Elstner EF.	Z Naturforsch C J Biosci	10.1515/znc-1998-1-204	1998
	Engineered Thermoanaerobacterium aotearoense with nfnAB knockout for improved hydrogen production from lignocellulose hydrolysates.	Li Y, Hu J, Qu C, Chen L, Guo X, Fu H, Wang J.	Biotechnol Biofuels	10.1186/s13068-019-1559-8	2019
Genetics	The genome of Clostridium kluyveri, a strict anaerobe with unique metabolic features.	Seedorf H, Fricke WF, Veith B, Bruggemann H, Liesegang H, Strittmatter A, Miethke M, Buckel W, Hinderberger J, Li F, Hagemeier C, Thauer RK, Gottschalk G.	Proc Natl Acad Sci U S A	10.1073/pnas.0711093105	2008
Metabolism	The Rnf Complex Is an Energy-Coupled Transhydrogenase Essential To Reversibly Link Cellular NADH and Ferredoxin Pools in the Acetogen Acetobacterium woodii.	Westphal L, Wiechmann A, Baker J, Minton NP, Muller V.	J Bacteriol	10.1128/jb.00357-18	2018
Enzymology	Purification and characterization of a coenzyme-A-dependent succinate-semialdehyde dehydrogenase from Clostridium kluyveri.	Sohling B, Gottschalk G.	Eur J Biochem	10.1111/j.1432-1033.1993.tb17641.x	1993
	A structured evaluation of genome-scale constraint-based modeling tools for microbial consortia.	Scott WT, Benito-Vaquerizo S, Zimmermann J, Bajic D, Heinken A, Suarez-Diez M, Schaap PJ.	PLoS Comput Biol	10.1371/journal.pcbi.1011363	2023
Metabolism	Succinate-ethanol fermentation in Clostridium kluyveri: purification and characterisation of 4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA delta 3-delta 2-isomerase.	Scherf U, Sohling B, Gottschalk G, Linder D, Buckel W.	Arch Microbiol	10.1007/bf00248699	1994
	Synthetic biology of microbes synthesizing polyhydroxyalkanoates (PHA).	Chen GQ, Jiang XR, Guo Y.	Synth Syst Biotechnol	10.1016/j.synbio.2016.09.006	2016
Metabolism	Identification and characterization of a re-citrate synthase in Dehalococcoides strain CBDB1.	Marco-Urrea E, Paul S, Khodaverdi V, Seifert J, von Bergen M, Kretzschmar U, Adrian L.	J Bacteriol	10.1128/jb.05120-11	2011
Metabolism	Identification and characterization of a bacterial core methionine synthase.	Deobald D, Hanna R, Shahryari S, Layer G, Adrian L.	Sci Rep	10.1038/s41598-020-58873-z	2020
	Comparative analysis of gene content evolution in phytoplasmas and mycoplasmas.	Chen LL, Chung WC, Lin CP, Kuo CH.	PLoS One	10.1371/journal.pone.0034407	2012
Genetics	Modelling microbial communities: Harnessing consortia for biotechnological applications.	Ibrahim M, Raajaraam L, Raman K.	Comput Struct Biotechnol J	10.1016/j.csbj.2021.06.048	2021
Metabolism	Biosynthesis of poly(4-hydroxybutyric acid) by recombinant strains of Escherichia coli.	Hein S, Sohling B, Gottschalk G, Steinbuchel A.	FEMS Microbiol Lett	10.1111/j.1574-6968.1997.tb12604.x	1997
Metabolism	Biosynthetic preparation of [riboflavin-2-14C]flavin adenine dinucleotide using Clostridium kluyveri.	Baldwin JE, Dreisbach JH, Veca A.	Prep Biochem	10.1080/00327489008050188	1990
Genetics	Genome Editing of the Anaerobic Thermophile Thermoanaerobacter ethanolicus Using Thermostable Cas9.	Le Y, Fu Y, Sun J.	Appl Environ Microbiol	10.1128/aem.01773-20	2020
	Metabolic Diversity and Aero-Tolerance in Anammox Bacteria from Geochemically Distinct Aquifers.	Mosley OE, Gios E, Weaver L, Close M, Daughney C, van der Raaij R, Martindale H, Handley KM.	mSystems	10.1128/msystems.01255-21	2022
	The complete genome sequence of Eubacterium limosum SA11, a metabolically versatile rumen acetogen.	Kelly WJ, Henderson G, Pacheco DM, Li D, Reilly K, Naylor GE, Janssen PH, Attwood GT, Altermann E, Leahy SC.	Stand Genomic Sci	10.1186/s40793-016-0147-9	2016
	Toward a Hybrid Biosensor System for Analysis of Organic and Volatile Fatty Acids in Fermentation Processes.	Rohlen DL, Pilas J, Dahmen M, Keusgen M, Selmer T, Schoning MJ.	Front Chem	10.3389/fchem.2018.00284	2018
Metabolism	Metabolic engineering of Escherichia coli for the synthesis of polyhydroxyalkanoates using acetate as a main carbon source.	Chen J, Li W, Zhang ZZ, Tan TW, Li ZJ.	Microb Cell Fact	10.1186/s12934-018-0949-0	2018
Enzymology	Alcohol dehydrogenases AdhE and AdhB with broad substrate ranges are important enzymes for organic acid reduction in Thermoanaerobacter sp. strain X514.	Hitschler L, Nissen LS, Kuntz M, Basen M.	Biotechnol Biofuels	10.1186/s13068-021-02038-1	2021
Genetics	Unraveling 1,4-Butanediol Metabolism in Pseudomonas putida KT2440.	Li WJ, Narancic T, Kenny ST, Niehoff PJ, O'Connor K, Blank LM, Wierckx N.	Front Microbiol	10.3389/fmicb.2020.00382	2020
	Diagnosing and Predicting Mixed-Culture Fermentations with Unicellular and Guild-Based Metabolic Models.	Scarborough MJ, Hamilton JJ, Erb EA, Donohue TJ, Noguera DR.	mSystems	10.1128/msystems.00755-20	2020
	The active microbial community more accurately reflects the anaerobic digestion process: 16S rRNA (gene) sequencing as a predictive tool.	De Vrieze J, Pinto AJ, Sloan WT, Ijaz UZ.	Microbiome	10.1186/s40168-018-0449-9	2018
Metabolism	Identification and characterization of re-citrate synthase in Syntrophus aciditrophicus.	Kim M, Le H, McInerney MJ, Buckel W.	J Bacteriol	10.1128/jb.02185-12	2013
Metabolism	Caffeate respiration in the acetogenic bacterium Acetobacterium woodii: a coenzyme A loop saves energy for caffeate activation.	Hess V, Gonzalez JM, Parthasarathy A, Parthasarathy A, Buckel W, Muller V.	Appl Environ Microbiol	10.1128/aem.03604-12	2013
	Characterization of the spore surface and exosporium proteins of Clostridium sporogenes; implications for Clostridium botulinum group I strains.	Janganan TK, Mullin N, Tzokov SB, Stringer S, Fagan RP, Hobbs JK, Moir A, Bullough PA.	Food Microbiol	10.1016/j.fm.2016.06.003	2016
	The di-peptide Trp-His activates AMP-activated protein kinase and enhances glucose uptake independently of insulin in L6 myotubes.	Soga M, Ohashi A, Taniguchi M, Matsui T, Tsuda T.	FEBS Open Bio	10.1016/j.fob.2014.10.008	2014
	Development of an Effective Chain Elongation Process From Acidified Food Waste and Ethanol Into n-Caproate.	Roghair M, Liu Y, Strik DPBTB, Weusthuis RA, Bruins ME, Buisman CJN.	Front Bioeng Biotechnol	10.3389/fbioe.2018.00050	2018
	Production of high-concentration n-caproic acid from lactate through fermentation using a newly isolated Ruminococcaceae bacterium CPB6.	Zhu X, Zhou Y, Wang Y, Wu T, Li X, Li D, Tao Y.	Biotechnol Biofuels	10.1186/s13068-017-0788-y	2017
Metabolism	Rapid kinetics reveal surprising flavin chemistry in bifurcating electron transfer flavoprotein from Acidaminococcus fermentans.	Sucharitakul J, Buckel W, Chaiyen P.	J Biol Chem	10.1074/jbc.ra120.016017	2021
Metabolism	A cytosolic chaperone complex controls folding and degradation of type III CD38.	Wu Y, Zhang J, Fang L, Lee HC, Zhao YJ.	J Biol Chem	10.1074/jbc.ra118.005844	2019
Pathogenicity	A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway.	Ghergurovich JM, Garcia-Canaveras JC, Wang J, Schmidt E, Zhang Z, TeSlaa T, Patel H, Chen L, Britt EC, Piqueras-Nebot M, Gomez-Cabrera MC, Lahoz A, Fan J, Beier UH, Kim H, Rabinowitz JD.	Nat Chem Biol	10.1038/s41589-020-0533-x	2020
Metabolism	Heterologous phosphoketolase expression redirects flux towards acetate, perturbs sugar phosphate pools and increases respiratory demand in Saccharomyces cerevisiae.	Bergman A, Hellgren J, Moritz T, Siewers V, Nielsen J, Chen Y.	Microb Cell Fact	10.1186/s12934-019-1072-6	2019
	Development and application of a high-throughput screening assay for identification of small molecule inhibitors of the P. falciparum reticulocyte binding-like homologue 5 protein.	Sleebs BE, Jarman KE, Frolich S, Wong W, Healer J, Dai W, Lucet IS, Wilson DW, Cowman AF.	Int J Parasitol Drugs Drug Resist	10.1016/j.ijpddr.2020.10.008	2020
Transcriptome	Sigma Factor Regulated Cellular Response in a Non-solvent Producing Clostridium beijerinckii Degenerated Strain: A Comparative Transcriptome Analysis.	Zhang Y, Jiao S, Lv J, Du R, Yan X, Wan C, Zhang R, Han B.	Front Microbiol	10.3389/fmicb.2017.00023	2017
	Encapsulation of methylene blue in polyacrylamide nanoparticle platforms protects its photodynamic effectiveness.	Tang W, Xu H, Park EJ, Philbert MA, Kopelman R.	Biochem Biophys Res Commun	10.1016/j.bbrc.2008.02.066	2008
Metabolism	Metagenomic insights into the RDX-degrading potential of the ovine rumen microbiome.	Li RW, Giarrizzo JG, Wu S, Li W, Duringer JM, Craig AM.	PLoS One	10.1371/journal.pone.0110505	2014
	Flavin-Based Electron Bifurcation, Ferredoxin, Flavodoxin, and Anaerobic Respiration With Protons (Ech) or NAD⁺ (Rnf) as Electron Acceptors: A Historical Review.	Buckel W, Thauer RK.	Front Microbiol	10.3389/fmicb.2018.00401	2018
Metabolism	Physiological limits to life in anoxic subseafloor sediment.	Orsi WD, Schink B, Buckel W, Martin WF.	FEMS Microbiol Rev	10.1093/femsre/fuaa004	2020
Biotechnology	Evolution-aided engineering of plant specialized metabolism.	Irfan M, Chavez B, Rizzo P, D'Auria JC, Moghe GD.	aBIOTECH	10.1007/s42994-021-00052-3	2021
Genetics	Comparative Genomic Analysis Reveals Novel Microcompartment-Associated Metabolic Pathways in the Human Gut Microbiome.	Ravcheev DA, Moussu L, Smajic S, Thiele I.	Front Genet	10.3389/fgene.2019.00636	2019
Phylogeny	Assignment of fatty acid-beta-oxidizing syntrophic bacteria to Syntrophomonadaceae fam. nov. on the basis of 16S rRNA sequence analyses.	Zhao H, Yang D, Woese CR, Bryant MP.	Int J Syst Bacteriol	10.1099/00207713-43-2-278	1993
	Diversity and Functional Analysis of the FeMo-Cofactor Maturase NifB.	Arragain S, Jimenez-Vicente E, Scandurra AA, Buren S, Rubio LM, Echavarri-Erasun C.	Front Plant Sci	10.3389/fpls.2017.01947	2017
Metabolism	Investigation of carbon metabolism in "Dehalococcoides ethenogenes" strain 195 by use of isotopomer and transcriptomic analyses.	Tang YJ, Yi S, Zhuang WQ, Zinder SH, Keasling JD, Alvarez-Cohen L.	J Bacteriol	10.1128/jb.00085-09	2009
Enzymology	Purification and some properties of an acryloyl-CoA reductase of Clostridium kluyveri.	Sedlmeier H, Simon H.	Biol Chem Hoppe Seyler	10.1515/bchm3.1985.366.2.953	1985
	Continuous n-valerate formation from propionate and methanol in an anaerobic chain elongation open-culture bioreactor.	de Smit SM, de Leeuw KD, Buisman CJN, Strik DPBTB.	Biotechnol Biofuels	10.1186/s13068-019-1468-x	2019
Metabolism	6-Hydroxypseudooxynicotine Dehydrogenase Delivers Electrons to Electron Transfer Flavoprotein during Nicotine Degradation by Agrobacterium tumefaciens S33.	Wang R, Yi J, Shang J, Yu W, Li Z, Huang H, Xie H, Wang S.	Appl Environ Microbiol	10.1128/aem.00454-19	2019
Genetics	Defining Genomic and Predicted Metabolic Features of the Acetobacterium Genus.	Ross DE, Marshall CW, Gulliver D, May HD, Norman RS.	mSystems	10.1128/msystems.00277-20	2020
Metabolism	Syntrophomonas wolfei Uses an NADH-Dependent, Ferredoxin-Independent [FeFe]-Hydrogenase To Reoxidize NADH.	Losey NA, Mus F, Peters JW, Le HM, McInerney MJ.	Appl Environ Microbiol	10.1128/aem.01335-17	2017
Metabolism	Energy Conservation Model Based on Genomic and Experimental Analyses of a Carbon Monoxide-Utilizing, Butyrate-Forming Acetogen, Eubacterium limosum KIST612.	Jeong J, Bertsch J, Hess V, Choi S, Choi IG, Chang IS, Muller V.	Appl Environ Microbiol	10.1128/aem.00675-15	2015
Enzymology	Simultaneous single-step purification of thiolase and NADP-dependent 3-hydroxybutyryl-CoA dehydrogenase from Clostridium kluyveri.	Sliwkowski MX, Hartmanis MG.	Anal Biochem	10.1016/0003-2697(84)90052-6	1984
	A Clostridium Group IV Species Dominates and Suppresses a Mixed Culture Fermentation by Tolerance to Medium Chain Fatty Acids Products.	Andersen SJ, De Groof V, Khor WC, Roume H, Props R, Coma M, Rabaey K.	Front Bioeng Biotechnol	10.3389/fbioe.2017.00008	2017
Metabolism	Incorporation and distribution of selenium into thiolase from Clostridium kluyveri.	Sliwkowski MX, Stadtman TC.	J Biol Chem	10.1016/s0021-9258(18)89484-4	1985
Metabolism	13C NMR studies of butyric fermentation in Clostridium kluyveri.	Smith GM, Kim BW, Franke AA, Roberts JD.	J Biol Chem	10.1016/s0021-9258(17)38751-3	1985
Metabolism	Comparative proteome analysis of propionate degradation by Syntrophobacter fumaroxidans in pure culture and in coculture with methanogens.	Sedano-Nunez VT, Boeren S, Stams AJM, Plugge CM.	Environ Microbiol	10.1111/1462-2920.14119	2018
Metabolism	Homoacetogenesis in Deep-Sea Chloroflexi, as Inferred by Single-Cell Genomics, Provides a Link to Reductive Dehalogenation in Terrestrial Dehalococcoidetes.	Sewell HL, Kaster AK, Spormann AM.	mBio	10.1128/mbio.02022-17	2017
Genetics	Hitherto unknown [Fe-Fe]-hydrogenase gene diversity in anaerobes and anoxic enrichments from a moderately acidic fen.	Schmidt O, Drake HL, Horn MA.	Appl Environ Microbiol	10.1128/aem.02895-09	2010
Phylogeny	Comparative genomic and functional analysis reveal conservation of plant growth promoting traits in Paenibacillus polymyxa and its closely related species.	Xie J, Shi H, Du Z, Wang T, Liu X, Chen S.	Sci Rep	10.1038/srep21329	2016
	Controlling Ethanol Use in Chain Elongation by CO₂ Loading Rate.	Roghair M, Hoogstad T, Strik DPBTB, Plugge CM, Timmers PHA, Weusthuis RA, Bruins ME, Buisman CJN.	Environ Sci Technol	10.1021/acs.est.7b04904	2018
Pathogenicity	Discovery of New Compounds Active against Plasmodium falciparum by High Throughput Screening of Microbial Natural Products.	Perez-Moreno G, Cantizani J, Sanchez-Carrasco P, Ruiz-Perez LM, Martin J, El Aouad N, Perez-Victoria I, Tormo JR, Gonzalez-Menendez V, Gonzalez I, de Pedro N, Reyes F, Genilloud O, Vicente F, Gonzalez-Pacanowska D.	PLoS One	10.1371/journal.pone.0145812	2016
	Advances in bio-based production of dicarboxylic acids longer than C4.	Yu JL, Qian ZG, Zhong JJ.	Eng Life Sci	10.1002/elsc.201800023	2018
Metabolism	Mesaconase/Fumarase FumD in Escherichia coli O157:H7 and Promiscuity of Escherichia coli Class I Fumarases FumA and FumB.	Kronen M, Berg IA.	PLoS One	10.1371/journal.pone.0145098	2015
Metabolism	Inhibitor potency varies widely among tumor-relevant human isocitrate dehydrogenase 1 mutants.	Avellaneda Matteo D, Wells GA, Luna LA, Grunseth AJ, Zagnitko O, Scott DA, Hoang A, Luthra A, Swairjo MA, Schiffer JM, Sohl CD.	Biochem J	10.1042/bcj20180424	2018
Metabolism	A eubacterial riboswitch class that senses the coenzyme tetrahydrofolate.	Ames TD, Rodionov DA, Weinberg Z, Breaker RR.	Chem Biol	10.1016/j.chembiol.2010.05.020	2010
Enzymology	On nitroaryl reductase activities in several Clostridia.	Angermaier L, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1983.364.2.1653	1983
Enzymology	Recombinant expression and characterisation of the oxygen-sensitive 2-enoate reductase from Clostridium sporogenes.	Mordaka PM, Hall SJ, Minton N, Stephens G.	Microbiology (Reading)	10.1099/mic.0.000568	2018
	Functional expression and evaluation of heterologous phosphoketolases in Saccharomyces cerevisiae.	Bergman A, Siewers V, Nielsen J, Chen Y.	AMB Express	10.1186/s13568-016-0290-0	2016
Metabolism	Medium Chain Carboxylic Acids from Complex Organic Feedstocks by Mixed Culture Fermentation.	De Groof V, Coma M, Arnot T, Leak DJ, Lanham AB.	Molecules	10.3390/molecules24030398	2019
Metabolism	Genome-Guided Analysis and Whole Transcriptome Profiling of the Mesophilic Syntrophic Acetate Oxidising Bacterium Syntrophaceticus schinkii.	Manzoor S, Bongcam-Rudloff E, Schnurer A, Muller B.	PLoS One	10.1371/journal.pone.0166520	2016
Metabolism	Acetyl coenzyme A and coenzyme a contents of growing clostridium kluyveri as determined by isotope assays.	Rossle M, Kreusch J, Decker K.	Arch Microbiol	10.1007/bf00425942	1981
Metabolism	The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production.	Schut GJ, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.01582-08	2009
Enzymology	Defining Electron Bifurcation in the Electron-Transferring Flavoprotein Family.	Garcia Costas AM, Poudel S, Miller AF, Schut GJ, Ledbetter RN, Fixen KR, Seefeldt LC, Adams MWW, Harwood CS, Boyd ES, Peters JW.	J Bacteriol	10.1128/jb.00440-17	2017
Metabolism	Effects of streptonigrin derivatives and sakyomicin A on the respiration of isolated rat liver mitochondria.	Inouye Y, Okada H, Uno J, Arai T, Nakamura S.	J Antibiot (Tokyo)	10.7164/antibiotics.39.550	1986
Enzymology	Degradation of NAD(H) by endogenous enzymes of yeasts and Clostridia.	Schuetz HJ, Simon H.	Z Naturforsch C J Biosci	10.1515/znc-1986-1-226	1986
	Role of the naphthoquinone moiety in the biological activities of sakyomicin A.	Take Y, Sawada M, Kunai H, Inouye Y, Nakamura S.	J Antibiot (Tokyo)	10.7164/antibiotics.39.557	1986
Metabolism	Gut microbiota-produced succinate promotes C. difficile infection after antibiotic treatment or motility disturbance.	Ferreyra JA, Wu KJ, Hryckowian AJ, Bouley DM, Weimer BC, Sonnenburg JL.	Cell Host Microbe	10.1016/j.chom.2014.11.003	2014
	Mechanism of inhibition of reverse transcriptase by quinone antibiotics. II. Dependence on putative quinone pocket on the enzyme molecule.	Hafuri Y, Takemori E, Oogose K, Inouye Y, Nakamura S, Kitahara Y, Nakahara S, Kubo A.	J Antibiot (Tokyo)	10.7164/antibiotics.41.1471	1988
Metabolism	Dynamics of cathode-associated microbial communities and metabolite profiles in a glycerol-fed bioelectrochemical system.	Dennis PG, Harnisch F, Yeoh YK, Tyson GW, Rabaey K.	Appl Environ Microbiol	10.1128/aem.00569-13	2013
Phylogeny	Prokaryotic communities in pit mud from different-aged cellars used for the production of Chinese strong-flavored liquor.	Tao Y, Li J, Rui J, Xu Z, Zhou Y, Hu X, Wang X, Liu M, Li D, Li X.	Appl Environ Microbiol	10.1128/aem.04070-13	2014
Pathogenicity	Comparative study on biological activities of heterocyclic quinones and streptonigrin.	Take Y, Oogose K, Kubo T, Inouye Y, Nakamura S, Kitahara Y, Kubo A.	J Antibiot (Tokyo)	10.7164/antibiotics.40.679	1987
Genetics	Genome and catabolic subproteomes of the marine, nutritionally versatile, sulfate-reducing bacterium Desulfococcus multivorans DSM 2059.	Dorries M, Wohlbrand L, Kube M, Reinhardt R, Rabus R.	BMC Genomics	10.1186/s12864-016-3236-7	2016
Metabolism	Stereospecific reductions of 2-en-1-ols catalyzed by Clostridium kluyveri.	Angermaier L, Bader J, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1981.362.1.33	1981
Metabolism	On the reduction of aliphatic and aromatic nitro compounds by Clostridia, the role of ferredoxin and its stabilization.	Angermaier L, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1983.364.2.961	1983
	Bioenergetic constraints for conversion of syngas to biofuels in acetogenic bacteria.	Bertsch J, Muller V.	Biotechnol Biofuels	10.1186/s13068-015-0393-x	2015
Metabolism	Broad substrate specificity of phosphotransbutyrylase from Listeria monocytogenes: A potential participant in an alternative pathway for provision of acyl CoA precursors for fatty acid biosynthesis.	Sirobhushanam S, Galva C, Sen S, Wilkinson BJ, Gatto C.	Biochim Biophys Acta	10.1016/j.bbalip.2016.06.003	2016
Metabolism	Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS.	Hiscox TJ, Harrison PF, Chakravorty A, Choo JM, Ohtani K, Shimizu T, Cheung JK, Rood JI.	PLoS One	10.1371/journal.pone.0073525	2013
Metabolism	Homolactic Acid Fermentation by the Genetically Engineered Thermophilic Homoacetogen Moorella thermoacetica ATCC 39073.	Iwasaki Y, Kita A, Yoshida K, Tajima T, Yano S, Shou T, Saito M, Kato J, Murakami K, Nakashimada Y.	Appl Environ Microbiol	10.1128/aem.00247-17	2017
Biotechnology	The use of the carbon/nitrogen ratio and specific organic loading rate as tools for improving biohydrogen production in fixed-bed reactors.	Anzola-Rojas MDP, Goncalves da Fonseca S, Canedo da Silva C, Maia de Oliveira V, Zaiat M.	Biotechnol Rep (Amst)	10.1016/j.btre.2014.10.010	2015
	Nano-photosensitizers Engineered to Generate a Tunable Mix of Reactive Oxygen Species, for Optimizing Photodynamic Therapy, Using a Microfluidic Device.	Yoon HK, Lou X, Chen YC, Koo Lee YE, Yoon E, Kopelman R.	Chem Mater	10.1021/cm403505s	2014
	A taxonomy of bacterial microcompartment loci constructed by a novel scoring method.	Axen SD, Erbilgin O, Kerfeld CA.	PLoS Comput Biol	10.1371/journal.pcbi.1003898	2014
Enzymology	An electron-bifurcating caffeyl-CoA reductase.	Bertsch J, Parthasarathy A, Parthasarathy A, Buckel W, Muller V.	J Biol Chem	10.1074/jbc.m112.444919	2013
	Simple enzymatic detection method for urinary sulfated 7 alpha-hydroxy bile acids in normal subjects and in patients with acute hepatitis.	Yamaguchi Y, Seki T, Watanabe S, Hayashi C, Miyai K.	J Chromatogr	10.1016/s0378-4347(00)80925-1	1983
Metabolism	ATP drives direct photosynthetic production of 1-butanol in cyanobacteria.	Lan EI, Liao JC.	Proc Natl Acad Sci U S A	10.1073/pnas.1200074109	2012
Metabolism	Production of butyrate from lysine and the Amadori product fructoselysine by a human gut commensal.	Bui TP, Ritari J, Boeren S, de Waard P, Plugge CM, de Vos WM.	Nat Commun	10.1038/ncomms10062	2015
Metabolism	Unravelling the Reduction Pathway as an Alternative Metabolic Route to Hydroxycinnamate Decarboxylation in Lactobacillus plantarum.	Santamaria L, Reveron I, Lopez de Felipe F, de Las Rivas B, Munoz R.	Appl Environ Microbiol	10.1128/aem.01123-18	2018
Metabolism	Protein Analysis of Sapienic Acid-Treated Porphyromonas gingivalis Suggests Differential Regulation of Multiple Metabolic Pathways.	Fischer CL, Dawson DV, Blanchette DR, Drake DR, Wertz PW, Brogden KA.	J Bacteriol	10.1128/jb.00665-15	2016
Metabolism	Genomic sequence and characterization of the virulent bacteriophage phiCTP1 from Clostridium tyrobutyricum and heterologous expression of its endolysin.	Mayer MJ, Payne J, Gasson MJ, Narbad A.	Appl Environ Microbiol	10.1128/aem.00989-10	2010
Enzymology	Alpha-isopropylmalate synthase as a marker for the leucine biosynthetic pathway in several clostridia and in Bacteroides fragilis.	Wiegel J.	Arch Microbiol	10.1007/bf00414605	1981
Metabolism	Coupling between d-3-phosphoglycerate dehydrogenase and d-2-hydroxyglutarate dehydrogenase drives bacterial l-serine synthesis.	Zhang W, Zhang M, Gao C, Zhang Y, Ge Y, Guo S, Guo X, Zhou Z, Liu Q, Zhang Y, Ma C, Tao F, Xu P.	Proc Natl Acad Sci U S A	10.1073/pnas.1619034114	2017
Metabolism	On the occurrence of enoate reductase and 2-oxo-carboxylate reductase in clostridia and some observations on the amino acid fermentation by Peptostreptococcus anaerobius.	Giesel H, Simon H.	Arch Microbiol	10.1007/bf00419482	1983
Metabolism	[On the specifity and stereospecificity of the conversion of different 2,3-unsaturated acids by Clostridium kluyveri (author's transl)].	Hashimoto H, Gunther H, Simon H.	Hoppe Seylers Z Physiol Chem		1975
Enzymology	On the mechanism and some properties of vinylacetyl-CoA delta-isomerase of Clostridium kluyveri.	Schleicher E, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1976.357.1.535	1976
Metabolism	Deletion of nfnAB in Thermoanaerobacterium saccharolyticum and Its Effect on Metabolism.	Lo J, Zheng T, Olson DG, Ruppertsberger N, Tripathi SA, Tian L, Guss AM, Lynd LR.	J Bacteriol	10.1128/jb.00347-15	2015
Enzymology	[The occurrence of a reductase of delta2-carboxylic acids in Clostridium kluyveri with a stereospecificity different from that of butyryl-CoA dehydrogenase (author's transl)].	Hashimoto H, Rambeck B, Gunther H, Mannschreck A, Simon H.	Hoppe Seylers Z Physiol Chem		1975
Metabolism	Substrate-induced radical formation in 4-hydroxybutyryl coenzyme A dehydratase from Clostridium aminobutyricum.	Zhang J, Friedrich P, Pierik AJ, Martins BM, Buckel W.	Appl Environ Microbiol	10.1128/aem.03099-14	2015
Enzymology	A bacterial electron-bifurcating hydrogenase.	Schuchmann K, Muller V.	J Biol Chem	10.1074/jbc.m112.395038	2012
Metabolism	Cyclohexanecarboxyl-coenzyme A (CoA) and cyclohex-1-ene-1-carboxyl-CoA dehydrogenases, two enzymes involved in the fermentation of benzoate and crotonate in Syntrophus aciditrophicus.	Kung JW, Seifert J, von Bergen M, Boll M.	J Bacteriol	10.1128/jb.00322-13	2013
	A global analysis of gene expression in Fibrobacter succinogenes S85 grown on cellulose and soluble sugars at different growth rates.	Neumann AP, Weimer PJ, Suen G.	Biotechnol Biofuels	10.1186/s13068-018-1290-x	2018
Metabolism	DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene.	Smart RC, Zannoni VG.	Mol Pharmacol	10.1016/s0026-895x(25)15064-5	1984
	Quantitative proteomic analysis of the influence of lignin on biofuel production by Clostridium acetobutylicum ATCC 824.	Raut MP, Couto N, Pham TK, Evans C, Noirel J, Wright PC.	Biotechnol Biofuels	10.1186/s13068-016-0523-0	2016
Metabolism	Sulfide oxidation by a noncanonical pathway in red blood cells generates thiosulfate and polysulfides.	Vitvitsky V, Yadav PK, Kurthen A, Banerjee R.	J Biol Chem	10.1074/jbc.m115.639831	2015
Enzymology	Development of a semiquantitative degenerate real-time pcr-based assay for estimation of numbers of butyryl-coenzyme A (CoA) CoA transferase genes in complex bacterial samples.	Louis P, Flint HJ.	Appl Environ Microbiol	10.1128/aem.02561-06	2007
Metabolism	A caffeyl-coenzyme A synthetase initiates caffeate activation prior to caffeate reduction in the acetogenic bacterium Acetobacterium woodii.	Hess V, Vitt S, Muller V.	J Bacteriol	10.1128/jb.01126-10	2011
Metabolism	Identification of cysteine and arginine residues essential for the phosphotransacetylase from Methanosarcina thermophila.	Rasche ME, Smith KS, Ferry JG.	J Bacteriol	10.1128/jb.179.24.7712-7717.1997	1997
	Waste Conversion into n-Caprylate and n-Caproate: Resource Recovery from Wine Lees Using Anaerobic Reactor Microbiomes and In-line Extraction.	Kucek LA, Xu J, Nguyen M, Angenent LT.	Front Microbiol	10.3389/fmicb.2016.01892	2016
Metabolism	A Quantitative System-Scale Characterization of the Metabolism of Clostridium acetobutylicum.	Yoo M, Bestel-Corre G, Croux C, Riviere A, Meynial-Salles I, Soucaille P.	mBio	10.1128/mbio.01808-15	2015
Stress	Accurate label-free reaction kinetics determination using initial rate heat measurements.	Ebrahimi KH, Hagedoorn PL, Jacobs D, Hagen WR.	Sci Rep	10.1038/srep16380	2015
Metabolism	Genetic analysis of Comamonas acidovorans polyhydroxyalkanoate synthase and factors affecting the incorporation of 4-hydroxybutyrate monomer.	Sudesh K, Fukui T, Doi Y.	Appl Environ Microbiol	10.1128/aem.64.9.3437-3443.1998	1998
Enzymology	Limits to Dihydrogen Incorporation into Electron Sinks Alternative to Methanogenesis in Ruminal Fermentation.	Ungerfeld EM.	Front Microbiol	10.3389/fmicb.2015.01272	2015
Metabolism	Improved productivity of poly (4-hydroxybutyrate) (P4HB) in recombinant Escherichia coli using glycerol as the growth substrate with fed-batch culture.	Le Meur S, Zinn M, Egli T, Thony-Meyer L, Ren Q.	Microb Cell Fact	10.1186/s12934-014-0131-2	2014
Enzymology	On the kinetics and mechanism of enoate reductase.	Buhler M, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1982.363.1.609	1982
Metabolism	Poly(4-hydroxybutyrate) (P4HB) production in recombinant Escherichia coli: P4HB synthesis is uncoupled with cell growth.	Le Meur S, Zinn M, Egli T, Thony-Meyer L, Ren Q.	Microb Cell Fact	10.1186/1475-2859-12-123	2013
	Cytosolic interaction of type III human CD38 with CIB1 modulates cellular cyclic ADP-ribose levels.	Liu J, Zhao YJ, Li WH, Hou YN, Li T, Zhao ZY, Fang C, Li SL, Lee HC.	Proc Natl Acad Sci U S A	10.1073/pnas.1703718114	2017
Metabolism	Two functionally distinct NADP⁺-dependent ferredoxin oxidoreductases maintain the primary redox balance of Pyrococcus furiosus.	Nguyen DMN, Schut GJ, Zadvornyy OA, Tokmina-Lukaszewska M, Poudel S, Lipscomb GL, Adams LA, Dinsmore JT, Nixon WJ, Boyd ES, Bothner B, Peters JW, Adams MWW.	J Biol Chem	10.1074/jbc.m117.794172	2017
Metabolism	The reduction of allyl alcohols by Clostridium species is catalyzed by the combined action of alcohol dehydrogenase and enoate reductase.	Bader J, Kim MA, Simon H.	Hoppe Seylers Z Physiol Chem	10.1515/bchm2.1981.362.1.809	1981
Metabolism	FAD is covalently attached to peptidyl-tRNA during cell-free synthesis of 6-hydroxy-D-nicotine oxidase.	Hamm HH, Decker K.	Eur J Biochem	10.1111/j.1432-1033.1978.tb12766.x	1978
Metabolism	Effects of overexpression of STB5 in Saccharomyces cerevisiae on fatty acid biosynthesis, physiology and transcriptome.	Bergman A, Vitay D, Hellgren J, Chen Y, Nielsen J, Siewers V.	FEMS Yeast Res	10.1093/femsyr/foz027	2019
Metabolism	Assignment of function to a domain of unknown function: DUF1537 is a new kinase family in catabolic pathways for acid sugars.	Zhang X, Carter MS, Vetting MW, San Francisco B, Zhao S, Al-Obaidi NF, Solbiati JO, Thiaville JJ, de Crecy-Lagard V, Jacobson MP, Almo SC, Gerlt JA.	Proc Natl Acad Sci U S A	10.1073/pnas.1605546113	2016
Metabolism	Insights into Flavin-based Electron Bifurcation via the NADH-dependent Reduced Ferredoxin:NADP Oxidoreductase Structure.	Demmer JK, Huang H, Wang S, Demmer U, Thauer RK, Ermler U.	J Biol Chem	10.1074/jbc.m115.656520	2015
Transcriptome	A Single-cell genome for Thiovulum sp.	Marshall IP, Blainey PC, Spormann AM, Quake SR.	Appl Environ Microbiol	10.1128/aem.02314-12	2012
Enzymology	Purification and some properties of a hitherto-unknown enzyme reducing the carbon-carbon double bond of alpha, beta-unsaturated carboxylate anions.	Tischer W, Bader J, Simon H.	Eur J Biochem	10.1111/j.1432-1033.1979.tb13090.x	1979
Genetics	What does the talking?: quorum sensing signalling genes discovered in a bacteriophage genome.	Hargreaves KR, Kropinski AM, Clokie MR.	PLoS One	10.1371/journal.pone.0085131	2014
	UDP-glucose dehydrogenase (UGDH) activity is suppressed by peroxide and promoted by PDGF in fibroblast-like synoviocytes: Evidence of a redox control mechanism.	Chandrasekaran R, Mathieu C, Sheth R, Cheng AP, Fong D, McCormack R, El-Gabalawy H, Alishetty S, Paige M, Hoemann CD.	PLoS One	10.1371/journal.pone.0274420	2022
Metabolism	Tubulin homolog TubZ in a phage-encoded partition system.	Oliva MA, Martin-Galiano AJ, Sakaguchi Y, Andreu JM.	Proc Natl Acad Sci U S A	10.1073/pnas.1121546109	2012
Metabolism	Clostridium ljungdahlii represents a microbial production platform based on syngas.	Kopke M, Held C, Hujer S, Liesegang H, Wiezer A, Wollherr A, Ehrenreich A, Liebl W, Gottschalk G, Durre P.	Proc Natl Acad Sci U S A	10.1073/pnas.1004716107	2010
Metabolism	Novel family of carbohydrate-binding modules revealed by the genome sequence of Spirochaeta thermophila DSM 6192.	Angelov A, Loderer C, Pompei S, Liebl W.	Appl Environ Microbiol	10.1128/aem.00523-11	2011
	Diversity and Function of Microbial Community in Chinese Strong-Flavor Baijiu Ecosystem: A Review.	Zou W, Zhao C, Luo H.	Front Microbiol	10.3389/fmicb.2018.00671	2018
Metabolism	Evidence for a hydrogenosomal-type anaerobic ATP generation pathway in Acanthamoeba castellanii.	Leger MM, Gawryluk RM, Gray MW, Roger AJ.	PLoS One	10.1371/journal.pone.0069532	2013
Metabolism	Extraordinary phylogenetic diversity and metabolic versatility in aquifer sediment.	Castelle CJ, Hug LA, Wrighton KC, Thomas BC, Williams KH, Wu D, Tringe SG, Singer SW, Eisen JA, Banfield JF.	Nat Commun	10.1038/ncomms3120	2013
Metabolism	Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease.	DePaoli-Roach AA, Contreras CJ, Segvich DM, Heiss C, Ishihara M, Azadi P, Roach PJ.	J Biol Chem	10.1074/jbc.m114.607796	2015
	Benzo[a]yrenedione/benzo[a]pyrenediol oxidation-reduction couples and the generation of reactive reduced molecular oxygen.	Lorentzen RJ, Ts'o PO.	Biochemistry	10.1021/bi00626a035	1977
Metabolism	Protein thiocarboxylate-dependent methionine biosynthesis in Wolinella succinogenes.	Krishnamoorthy K, Begley TP.	J Am Chem Soc	10.1021/ja107424t	2011
	Methylene blue covalently loaded polyacrylamide nanoparticles for enhanced tumor-targeted photodynamic therapy.	Qin M, Hah HJ, Kim G, Nie G, Lee YE, Kopelman R.	Photochem Photobiol Sci	10.1039/c1pp05022b	2011
Metabolism	Physiological adaptation of Desulfitobacterium hafniense strain TCE1 to tetrachloroethene respiration.	Prat L, Maillard J, Grimaud R, Holliger C.	Appl Environ Microbiol	10.1128/aem.02471-10	2011
Metabolism	Energy conservation via electron-transferring flavoprotein in anaerobic bacteria.	Herrmann G, Jayamani E, Mai G, Buckel W.	J Bacteriol	10.1128/jb.01422-07	2008
Metabolism	Mutant and Wild-Type Isocitrate Dehydrogenase 1 Share Enhancing Mechanisms Involving Distinct Tyrosine Kinase Cascades in Cancer.	Chen D, Xia S, Wang M, Lin R, Li Y, Mao H, Aguiar M, Famulare CA, Shih AH, Brennan CW, Gao X, Gao X, Pan Y, Liu S, Fan J, Jin L, Song L, Zhou A, Mukherjee J, Pieper RO, Mishra A, Peng J, Arellano M, Blum WG, Lonial S, Boggon TJ, Levine RL, Chen J.	Cancer Discov	10.1158/2159-8290.cd-18-1040	2019
Metabolism	Diverse Energy-Conserving Pathways in Clostridium difficile: Growth in the Absence of Amino Acid Stickland Acceptors and the Role of the Wood-Ljungdahl Pathway.	Gencic S, Grahame DA.	J Bacteriol	10.1128/jb.00233-20	2020
Metabolism	Genomic island TnSmu2 of Streptococcus mutans harbors a nonribosomal peptide synthetase-polyketide synthase gene cluster responsible for the biosynthesis of pigments involved in oxygen and H2O2 tolerance.	Wu C, Cichewicz R, Li Y, Liu J, Roe B, Ferretti J, Merritt J, Qi F.	Appl Environ Microbiol	10.1128/aem.03079-09	2010
Metabolism	Carbon flow of heliobacteria is related more to clostridia than to the green sulfur bacteria.	Tang KH, Feng X, Zhuang WQ, Alvarez-Cohen L, Blankenship RE, Tang YJ.	J Biol Chem	10.1074/jbc.m110.163303	2010
	Characterization of streptococcal platelet-activating factor acetylhydrolase variants that are involved in innate immune evasion.	Liu G, Liu M, Xie G, Lei B.	Infect Immun	10.1128/iai.00398-13	2013
Metabolism	Localization of proteins to the 1,2-propanediol utilization microcompartment by non-native signal sequences is mediated by a common hydrophobic motif.	Jakobson CM, Kim EY, Slininger MF, Chien A, Tullman-Ercek D.	J Biol Chem	10.1074/jbc.m115.651919	2015
Enzymology	Biochemistry, evolution and physiological function of the Rnf complex, a novel ion-motive electron transport complex in prokaryotes.	Biegel E, Schmidt S, Gonzalez JM, Muller V.	Cell Mol Life Sci	10.1007/s00018-010-0555-8	2011
Genetics	Complete Genomes of Bacillus coagulans S-lac and Bacillus subtilis TO-A JPC, Two Phylogenetically Distinct Probiotics.	Khatri I, Sharma S, Ramya TN, Subramanian S.	PLoS One	10.1371/journal.pone.0156745	2016
	Regulation of virulence by the RevR response regulator in Clostridium perfringens.	Hiscox TJ, Chakravorty A, Choo JM, Ohtani K, Shimizu T, Cheung JK, Rood JI.	Infect Immun	10.1128/iai.00060-11	2011
Metabolism	Coupling of ferredoxin and heterodisulfide reduction via electron bifurcation in hydrogenotrophic methanogenic archaea.	Kaster AK, Moll J, Parey K, Thauer RK.	Proc Natl Acad Sci U S A	10.1073/pnas.1016761108	2011
Metabolism	A reversible electron-bifurcating ferredoxin- and NAD-dependent [FeFe]-hydrogenase (HydABC) in Moorella thermoacetica.	Wang S, Huang H, Kahnt J, Thauer RK.	J Bacteriol	10.1128/jb.02158-12	2013
	Enzymic synthesis and cofactor activity of 3'-pyrophosphocoenzyme A.	Mukai JI, Sy J, Lipmann F.	Proc Natl Acad Sci U S A	10.1073/pnas.80.10.2899	1983
Metabolism	Electron bifurcation involved in the energy metabolism of the acetogenic bacterium Moorella thermoacetica growing on glucose or H2 plus CO2.	Huang H, Wang S, Moll J, Thauer RK.	J Bacteriol	10.1128/jb.00385-12	2012
Enzymology	Isolation of a selenium-containing thiolase from Clostridium kluyveri: identification of the selenium moiety as selenomethionine.	Hartmanis MG, Stadtman TC.	Proc Natl Acad Sci U S A	10.1073/pnas.79.16.4912	1982
Enzymology	The roles of univalent cations during catalysis by phosphate acetyltransferase derived from Clostridium kluyveri.	Kyrtopoulos SA, Satchell DP.	Biochem J	10.1042/bj1291163	1972
Metabolism	Systems-level metabolic flux profiling elucidates a complete, bifurcated tricarboxylic acid cycle in Clostridium acetobutylicum.	Amador-Noguez D, Feng XJ, Fan J, Roquet N, Rabitz H, Rabinowitz JD.	J Bacteriol	10.1128/jb.00490-10	2010
Metabolism	A dicarboxylate/4-hydroxybutyrate autotrophic carbon assimilation cycle in the hyperthermophilic Archaeum Ignicoccus hospitalis.	Huber H, Gallenberger M, Jahn U, Eylert E, Berg IA, Kockelkorn D, Eisenreich W, Fuchs G.	Proc Natl Acad Sci U S A	10.1073/pnas.0801043105	2008
Metabolism	Structural insight into the Clostridium difficile ethanolamine utilisation microcompartment.	Pitts AC, Tuck LR, Faulds-Pain A, Lewis RJ, Marles-Wright J.	PLoS One	10.1371/journal.pone.0048360	2012
Metabolism	Studies on the mechanism of electron bifurcation catalyzed by electron transferring flavoprotein (Etf) and butyryl-CoA dehydrogenase (Bcd) of Acidaminococcus fermentans.	Chowdhury NP, Mowafy AM, Demmer JK, Upadhyay V, Koelzer S, Jayamani E, Kahnt J, Hornung M, Demmer U, Ermler U, Buckel W.	J Biol Chem	10.1074/jbc.m113.521013	2014
Metabolism	Thermoanaerobacter thermohydrosulfuricus WC1 shows protein complement stability during fermentation of key lignocellulose-derived substrates.	Verbeke TJ, Spicer V, Krokhin OV, Zhang X, Schellenberg JJ, Fristensky B, Wilkins JA, Levin DB, Sparling R.	Appl Environ Microbiol	10.1128/aem.03555-13	2014
Enzymology	Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.	Bock AK, Glasemacher J, Schmidt R, Schonheit P.	J Bacteriol	10.1128/jb.181.6.1861-1867.1999	1999
Metabolism	Pyruvate formate lyase acts as a formate supplier for metabolic processes during anaerobiosis in Staphylococcus aureus.	Leibig M, Liebeke M, Mader D, Lalk M, Peschel A, Gotz F.	J Bacteriol	10.1128/jb.01161-10	2011
Metabolism	Identification of the aryl hydrocarbon receptor target gene TiPARP as a mediator of suppression of hepatic gluconeogenesis by 2,3,7,8-tetrachlorodibenzo-p-dioxin and of nicotinamide as a corrective agent for this effect.	Diani-Moore S, Ram P, Li X, Mondal P, Youn DY, Sauve AA, Rifkind AB.	J Biol Chem	10.1074/jbc.m110.131573	2010
	Combined inactivation of the Clostridium cellulolyticum lactate and malate dehydrogenase genes substantially increases ethanol yield from cellulose and switchgrass fermentations.	Li Y, Tschaplinski TJ, Engle NL, Hamilton CY, Rodriguez M, Liao JC, Schadt CW, Guss AM, Yang Y, Graham DE.	Biotechnol Biofuels	10.1186/1754-6834-5-2	2012
Metabolism	First insights into the syntrophic acetate-oxidizing bacteria--a genetic study.	Muller B, Sun L, Schnurer A.	Microbiologyopen	10.1002/mbo3.50	2013
	Hydrogen evolution by a chloroplast-ferredoxin-hydrogenase system.	Benemann JR, Berenson JA, Kaplan NO, Kamen MD.	Proc Natl Acad Sci U S A	10.1073/pnas.70.8.2317	1973
Metabolism	Effects of hydrogen sulfide-releasing L-DOPA derivatives on glial activation: potential for treating Parkinson disease.	Lee M, Tazzari V, Giustarini D, Rossi R, Sparatore A, Del Soldato P, McGeer E, McGeer PL.	J Biol Chem	10.1074/jbc.m110.115261	2010
Genetics	Bacterial lifestyle in a deep-sea hydrothermal vent chimney revealed by the genome sequence of the thermophilic bacterium Deferribacter desulfuricans SSM1.	Takaki Y, Shimamura S, Nakagawa S, Fukuhara Y, Horikawa H, Ankai A, Harada T, Hosoyama A, Oguchi A, Fukui S, Fujita N, Takami H, Takai K.	DNA Res	10.1093/dnares/dsq005	2010
Biotechnology	High-throughput genome sequencing of two Listeria monocytogenes clinical isolates during a large foodborne outbreak.	Gilmour MW, Graham M, Van Domselaar G, Tyler S, Kent H, Trout-Yakel KM, Larios O, Allen V, Lee B, Nadon C.	BMC Genomics	10.1186/1471-2164-11-120	2010
	CRISPR-Cas Systems in Bacteroides fragilis, an Important Pathobiont in the Human Gut Microbiome.	Tajkarimi M, Wexler HM.	Front Microbiol	10.3389/fmicb.2017.02234	2017
Genetics	The complete genome sequence and analysis of Corynebacterium diphtheriae NCTC13129.	Cerdeno-Tarraga AM, Efstratiou A, Dover LG, Holden MT, Pallen M, Bentley SD, Besra GS, Churcher C, James KD, De Zoysa A, Chillingworth T, Cronin A, Dowd L, Feltwell T, Hamlin N, Holroyd S, Jagels K, Moule S, Quail MA, Rabbinowitsch E, Rutherford KM, Thomson NR, Unwin L, Whitehead S, Barrell BG, Parkhill J.	Nucleic Acids Res	10.1093/nar/gkg874	2003
Pathogenicity	Transcriptomic analysis of Clostridium thermocellum Populus hydrolysate-tolerant mutant strain shows increased cellular efficiency in response to Populus hydrolysate compared to the wild type strain.	Linville JL, Rodriguez M, Brown SD, Mielenz JR, Cox CD.	BMC Microbiol	10.1186/s12866-014-0215-5	2014
Enzymology	Origin and Evolution of Flavin-Based Electron Bifurcating Enzymes.	Poudel S, Dunham EC, Lindsay MR, Amenabar MJ, Fones EM, Colman DR, Boyd ES.	Front Microbiol	10.3389/fmicb.2018.01762	2018
Metabolism	Malonic semialdehyde reductase, succinic semialdehyde reductase, and succinyl-coenzyme A reductase from Metallosphaera sedula: enzymes of the autotrophic 3-hydroxypropionate/4-hydroxybutyrate cycle in Sulfolobales.	Kockelkorn D, Fuchs G.	J Bacteriol	10.1128/jb.00794-09	2009
Enzymology	Identification of missing genes and enzymes for autotrophic carbon fixation in crenarchaeota.	Ramos-Vera WH, Weiss M, Strittmatter E, Kockelkorn D, Fuchs G.	J Bacteriol	10.1128/jb.01156-10	2011
Enzymology	The Genome of Nitrospina gracilis Illuminates the Metabolism and Evolution of the Major Marine Nitrite Oxidizer.	Lucker S, Nowka B, Rattei T, Spieck E, Daims H.	Front Microbiol	10.3389/fmicb.2013.00027	2013
Metabolism	Acetate assimilation pathway of Methanosarcina barkeri.	Weimer PJ, Zeikus JG.	J Bacteriol	10.1128/jb.137.1.332-339.1979	1979
Metabolism	The genetic basis of energy conservation in the sulfate-reducing bacterium Desulfovibrio alaskensis G20.	Price MN, Ray J, Wetmore KM, Kuehl JV, Bauer S, Deutschbauer AM, Arkin AP.	Front Microbiol	10.3389/fmicb.2014.00577	2014
Metabolism	Cyclohexane carboxylate and benzoate formation from crotonate in Syntrophus aciditrophicus.	Mouttaki H, Nanny MA, McInerney MJ.	Appl Environ Microbiol	10.1128/aem.02227-06	2007
Metabolism	Initial reaction(s) in biotransformation of CL-20 is catalyzed by salicylate 1-monooxygenase from Pseudomonas sp. strain ATCC 29352.	Bhushan B, Halasz A, Spain JC, Hawari J.	Appl Environ Microbiol	10.1128/aem.70.7.4040-4047.2004	2004
Metabolism	Biotransformation of 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) by denitrifying Pseudomonas sp. strain FA1.	Bhushan B, Paquet L, Spain JC, Hawari J.	Appl Environ Microbiol	10.1128/aem.69.9.5216-5221.2003	2003
Enzymology	Determinants of catalytic power and ligand binding in glutamate racemase.	Spies MA, Reese JG, Dodd D, Pankow KL, Blanke SR, Baudry J.	J Am Chem Soc	10.1021/ja809660g	2009
	Genomic evidence for the evolution of Streptococcus equi: host restriction, increased virulence, and genetic exchange with human pathogens.	Holden MT, Heather Z, Paillot R, Steward KF, Webb K, Ainslie F, Jourdan T, Bason NC, Holroyd NE, Mungall K, Quail MA, Sanders M, Simmonds M, Willey D, Brooks K, Aanensen DM, Spratt BG, Jolley KA, Maiden MC, Kehoe M, Chanter N, Bentley SD, Robinson C, Maskell DJ, Parkhill J, Waller AS.	PLoS Pathog	10.1371/journal.ppat.1000346	2009
Metabolism	Acidic fibroblast growth factor (FGF) potentiates glial-mediated neurotoxicity by activating FGFR2 IIIb protein.	Lee M, Kang Y, Suk K, Schwab C, Yu S, McGeer PL.	J Biol Chem	10.1074/jbc.m111.270470	2011
Metabolism	Structural insight into the heme-based redox sensing by DosS from Mycobacterium tuberculosis.	Cho HY, Cho HJ, Kim YM, Oh JI, Kang BS.	J Biol Chem	10.1074/jbc.m808905200	2009
Metabolism	Metabolic engineering of a novel propionate-independent pathway for the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in recombinant Salmonella enterica serovar typhimurium.	Aldor IS, Kim SW, Prather KL, Keasling JD.	Appl Environ Microbiol	10.1128/aem.68.8.3848-3854.2002	2002
Metabolism	Pathway confirmation and flux analysis of central metabolic pathways in Desulfovibrio vulgaris hildenborough using gas chromatography-mass spectrometry and Fourier transform-ion cyclotron resonance mass spectrometry.	Tang Y, Pingitore F, Mukhopadhyay A, Phan R, Hazen TC, Keasling JD.	J Bacteriol	10.1128/jb.00948-06	2007
Metabolism	Malonyl-coenzyme A reductase from Chloroflexus aurantiacus, a key enzyme of the 3-hydroxypropionate cycle for autotrophic CO(2) fixation.	Hugler M, Menendez C, Schagger H, Fuchs G.	J Bacteriol	10.1128/jb.184.9.2404-2410.2002	2002
Metabolism	Metabolic pathways for cytotoxic end product formation from glutamate- and aspartate-containing peptides by Porphyromonas gingivalis.	Takahashi N, Sato T, Yamada T.	J Bacteriol	10.1128/jb.182.17.4704-4710.2000	2000
Phylogeny	Revised phylogeny and novel horizontally acquired virulence determinants of the model soft rot phytopathogen Pectobacterium wasabiae SCC3193.	Nykyri J, Niemi O, Koskinen P, Nokso-Koivisto J, Pasanen M, Broberg M, Plyusnin I, Toronen P, Holm L, Pirhonen M, Palva ET.	PLoS Pathog	10.1371/journal.ppat.1003013	2012
Enzymology	The CD38-independent ADP-ribosyl cyclase from mouse brain synaptosomes: a comparative study of neonate and adult brain.	Ceni C, Pochon N, Villaz M, Muller-Steffner H, Schuber F, Baratier J, De Waard M, Ronjat M, Moutin MJ.	Biochem J	10.1042/bj20051321	2006
	Gas Fermentation-A Flexible Platform for Commercial Scale Production of Low-Carbon-Fuels and Chemicals from Waste and Renewable Feedstocks.	Liew F, Martin ME, Tappel RC, Heijstra BD, Mihalcea C, Kopke M.	Front Microbiol	10.3389/fmicb.2016.00694	2016
	Ammonia production by ruminal microorganisms and enumeration, isolation, and characterization of bacteria capable of growth on peptides and amino acids from the sheep rumen.	Eschenlauer SC, McKain N, Walker ND, McEwan NR, Newbold CJ, Wallace RJ.	Appl Environ Microbiol	10.1128/aem.68.10.4925-4931.2002	2002
Enzymology	Elucidation of enzymes in fermentation pathways used by Clostridium thermosuccinogenes growing on inulin.	Sridhar J, Eiteman MA, Wiegel JW.	Appl Environ Microbiol	10.1128/aem.66.1.246-251.2000	2000
Metabolism	Genome sequence of Desulfobacterium autotrophicum HRM2, a marine sulfate reducer oxidizing organic carbon completely to carbon dioxide.	Strittmatter AW, Liesegang H, Rabus R, Decker I, Amann J, Andres S, Henne A, Fricke WF, Martinez-Arias R, Bartels D, Goesmann A, Krause L, Puhler A, Klenk HP, Richter M, Schuler M, Glockner FO, Meyerdierks A, Gottschalk G, Amann R.	Environ Microbiol	10.1111/j.1462-2920.2008.01825.x	2009
Pathogenicity	Reduction of human monocytic cell neurotoxicity and cytokine secretion by ligands of the cannabinoid-type CB2 receptor.	Klegeris A, Bissonnette CJ, McGeer PL.	Br J Pharmacol	10.1038/sj.bjp.0705304	2003
Metabolism	The 17-gene ethanolamine (eut) operon of Salmonella typhimurium encodes five homologues of carboxysome shell proteins.	Kofoid E, Rappleye C, Stojiljkovic I, Roth J.	J Bacteriol	10.1128/jb.181.17.5317-5329.1999	1999
Enzymology	Purification and characterization of ferredoxin-nicotinamide adenine dinucleotide phosphate reductase from a nitrogen-fixing bacterium.	Yoch DC.	J Bacteriol	10.1128/jb.116.1.384-391.1973	1973
	The Nutrition of Clostridium kluyveri.	Bornstein BT, Barker HA.	J Bacteriol	10.1128/jb.55.2.223-230.1948	1948
Metabolism	FAILURE OF ARSENATE TO UNCOUPLE THE PHOSPHOTRANSACETYLASE SYSTEM IN CLOSTRIDIUM ACIDIURICI.	SAGERS RD, BENZIMAN M, KLEIN SM.	J Bacteriol	10.1128/jb.86.5.978-984.1963	1963
Genetics	Complete genome sequence and analysis of the multiresistant nosocomial pathogen Corynebacterium jeikeium K411, a lipid-requiring bacterium of the human skin flora.	Tauch A, Kaiser O, Hain T, Goesmann A, Weisshaar B, Albersmeier A, Bekel T, Bischoff N, Brune I, Chakraborty T, Kalinowski J, Meyer F, Rupp O, Schneiker S, Viehoever P, Puhler A.	J Bacteriol	10.1128/jb.187.13.4671-4682.2005	2005
Metabolism	The bifunctional Entamoeba histolytica alcohol dehydrogenase 2 (EhADH2) protein is necessary for amebic growth and survival and requires an intact C-terminal domain for both alcohol dahydrogenase and acetaldehyde dehydrogenase activity.	Espinosa A, Yan L, Zhang Z, Foster L, Clark D, Li E, Stanley SL.	J Biol Chem	10.1074/jbc.m101349200	2001
Metabolism	A novel streptococcal integrative conjugative element involved in iron acquisition.	Heather Z, Holden MT, Steward KF, Parkhill J, Song L, Challis GL, Robinson C, Davis-Poynter N, Waller AS.	Mol Microbiol	10.1111/j.1365-2958.2008.06481.x	2008
Phylogeny	The ald gene, encoding a coenzyme A-acylating aldehyde dehydrogenase, distinguishes Clostridium beijerinckii and two other solvent-producing clostridia from Clostridium acetobutylicum.	Toth J, Ismaiel AA, Chen JS.	Appl Environ Microbiol	10.1128/aem.65.11.4973-4980.1999	1999
Metabolism	Degradation of aromatics and chloroaromatics by Pseudomonas sp. strain B13: purification and characterization of 3-oxoadipate:succinyl-coenzyme A (CoA) transferase and 3-oxoadipyl-CoA thiolase.	Kaschabek SR, Kuhn B, Muller D, Schmidt E, Reineke W.	J Bacteriol	10.1128/jb.184.1.207-215.2002	2002
Metabolism	Insights into the autotrophic CO2 fixation pathway of the archaeon Ignicoccus hospitalis: comprehensive analysis of the central carbon metabolism.	Jahn U, Huber H, Eisenreich W, Hugler M, Fuchs G.	J Bacteriol	10.1128/jb.00047-07	2007
Enzymology	Study of some enzyme systems by means of the differential microrespirometer.	ENTNER N, KIRK PL.	J Gen Physiol	10.1085/jgp.34.4.431	1951
Metabolism	The reduction of vinylacetate by Clostridium kluyveri and its dependence on catalytic amounts of high-energy acetate.	PEEL JL, BARKER HA.	Biochem J	10.1042/bj0620323	1956
Metabolism	The Synthesis of Butyric and Caproic Acids from Ethanol and Acetic Acid by Clostridium Kluyveri.	Barker HA, Kamen MD, Bornstein BT.	Proc Natl Acad Sci U S A	10.1073/pnas.31.12.373	1945
	Ethanol:propionate ratio drives product selectivity in odd-chain elongation with Clostridium kluyveri and mixed communities.	Candry P, Ulcar B, Petrognani C, Rabaey K, Ganigue R	Bioresour Technol	10.1016/j.biortech.2020.123651	2020
Metabolism	Utilization of (E)-2-butenoate (crotonate) by Clostridium kluyveri and some other Clostridium species.	Bader J, Gunther H, Schleicher E, Simon H, Pohl S, Mannheim W	Arch Microbiol	10.1007/BF00403214	1980
Metabolism	Properties of two Clostridia strains acting as catalysts for the preparative stereospecific hydrogenation of 2-enoic acids and 2-alken-1-ols with hydrogen gas.	Bader J, Gunther H, Rambeck B, Simon H	Hoppe Seylers Z Physiol Chem	10.1515/bchm.1978.359.1.19	1978
Enzymology	Medium-Chain Fatty Acid Synthesis by "Candidatus Weimeria bifida" gen. nov., sp. nov., and "Candidatus Pseudoramibacter fermentans" sp. nov.	Scarborough MJ, Myers KS, Donohue TJ, Noguera DR.	Appl Environ Microbiol	10.1128/aem.02242-19	2020
Phylogeny	Clostridium luticellarii sp. nov., isolated from a mud cellar used for producing strong aromatic liquors.	Wang Q, Wang CD, Li CH, Li JG, Chen Q, Li YZ	Int J Syst Evol Microbiol	10.1099/ijsem.0.000641	2015

References

#276	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 555
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Clostridium kluyveri (DSM 555, ATCC 12489, ATCC 8527)

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