Treponema maltophilum (DSM 27366, ATCC 51939, CIP 105146)

Name: Treponema maltophilum (DSM 27366, ATCC 51939, CIP 105146)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 23288

Type strain

Strain Designation BR

Culture col. no. DSM 27366 ATCC 51939 CIP 105146 OMZ 679 BR

NCBI tax ID(s) 1125699 51160

Special Collections DSMZ CIP

History DSMZ <- CIP <- C. Wyss; OMZ 679 CIP <- 1997, C. Wyss, Zürich Univ., Switzerland: strain OMZ 679 CIP <- 1997, C. Wyss, Zürich Univ., Switzerland: strain OMZ 679

Links

Treponema maltophilum BR is an anaerobe bacterium that was isolated from human periodontal lesions.

anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 43254

ATCC 51939,CIP 105146,DSM 27366

@ref 20215

Last LPSN update 2026-05-29 08:30:25

Domain Bacteria

Phylum Spirochaetota

Class Spirochaetia

Order Spirochaetales

Family Treponemataceae

Genus Treponema

Species Treponema maltophilum

Full scientific name Treponema maltophilum Wyss et al. 1996

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	98.299

Colony morphology

19045

Incubation period2-3 days

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
19045	OMIZ-PAT (DSMZ Medium 1494)	Medium recipe at MediaDive	Name: . OMIZ-PAT Medium (modified) (DSMZ Medium 1494) Composition: (NH4)6Mo7O24 x 4 H2O 12.4 g/l Yeast extract 3.0 g/l Fe SO4 x 7 H2O 2.78015 g/l D-Glucose 2.0 g/l D-Mannose 2.0 g/l D-Arabinose 2.0 g/l L-Fucose 2.0 g/l D-Trehalose 2.0 g/l D-Sucrose 2.0 g/l L-Rhamnose 2.0 g/l NH4Cl 1.6 g/l Glutathione 1.5366 g/l Ascorbic acid 1.0 g/l NaHCO3 1.0 g/l Ethanol 1.0 g/l KCl 0.968 g/l D-Maltose 0.8 g/l D-glucuronic acid 0.8 g/l D-Mannitol 0.8 g/l D-galacturonic acid 0.8 g/l D-Fructose 0.8 g/l L-Glutamine 0.68 g/l L-Histidine 0.62 g/l NaVO3 0.61 g/l D 0.56 g/l Pyruvic acid 0.55 g/l L-Serine 0.525 g/l Fumaric acid 0.5 g/l HCl 0.3646 g/l L-Cysteine HCl 0.35 g/l L-Glutamic acid 0.3 g/l Formic acid 0.3 g/l ZnSO4 x 7 H2O 0.287 g/l MgSO4 x 7 H2O 0.25 g/l DL-carnitine 0.2 g/l N-Acetylglucosamine 0.2 g/l Citric acid 0.2 g/l L-Lysine HCl 0.182 g/l L-Arginine 0.175 g/l L-Ornithine HCl 0.17 g/l L-Phenylalanine 0.165 g/l CaCl2 x H2O 0.15 g/l L-Methionine 0.15 g/l L-Asparagine 0.15 g/l NaH2PO4 x H2O 0.14 g/l L-Leucine 0.131 g/l L-Isoleucine 0.131 g/l NiSO4 x 6 H2O 0.131 g/l L-Threonine 0.12 g/l L-Aspartic acid 0.118 g/l SnCl2 x 2 H2O 0.118 g/l L-Valine 0.117 g/l L-Proline 0.115 g/l L-Tryptophan 0.102 g/l Nicotinic acid 0.1 g/l Folinic acid 0.1 g/l L-Tyrosine 0.09 g/l NaOH 0.079994 g/l Glycine 0.075 g/l Nicotinamide 0.05 g/l Folic acid 0.05 g/l D-(+)-biotin 0.05 g/l Vitamine B12 0.05 g/l Choline chloride 0.05 g/l Myo-inositol 0.05 g/l L-Alanine 0.045 g/l Hemin 0.026076 g/l N-acetylmuramic acid 0.025 g/l Na2SeO3 0.0173 g/l MnSO4 x H2O 0.0169 g/l Riboflavine 0.01 g/l 2-Mercaptoethanesulfonic acid 0.01 g/l Phenol red 0.01 g/l Putrescine 2 HCl 0.005 g/l Pyridoxal hydrochloride 0.005 g/l Pyridoxal phosphate 0.005 g/l Calcium D-(+)-pantothenate 0.005 g/l Thiamine HCl 0.005 g/l Thiamin pyrophosphate 0.005 g/l Thymidine 0.0024 g/l N-(2-acetamido)-2-aminoethanesulfonic acid 0.0018 g/l Hypoxanthine 0.0014 g/l Uracil 0.0011 g/l Flavin adenine dinucleotide 0.001 g/l ß-nicotinamide adenine dinucleotide 0.001 g/l Coenzym A 0.001 g/l CuSO4 0.000789 g/l Cholesterol Asialofetuin 2-Mercaptoethanol Isovaleric acid Valeric acid 2-Methylbutyric acid Isobutyric acid DL-alpha-lipoic acid Rabbit serum Distilled water
37205	MEDIUM 155 - for Treponema maltophilum		Distilled water make up to (67.000 ml);Sodium chloride (2.500 g);Maltose(2.000 g);Horse serum (333.000 ml);Agar (0.150 g);Yeast extract (5.000 g);Potato dextrose broth (5.000 g);N-Acetyl glucosamine (0.200 g);Sodium thyoglycolate (0.500 g);L-Cysteine (1.0
120773	CIP Medium 155	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
19045	positive	growth	37
37205	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
19045	anaerobe
125438	anaerobe	90.934
125439	obligate aerobe	92.191

Spore formation

@ref	Spore formation	Confidence
125439		99.841

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	ethanol fermentation	100	2 of 2
66794	adipate degradation	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	lipoate biosynthesis	100	5 of 5
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	L-lactaldehyde degradation	100	3 of 3
66794	ribulose monophosphate pathway	100	2 of 2
66794	teichoic acid biosynthesis	100	1 of 1
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	dolichol and dolichyl phosphate biosynthesis	100	2 of 2
66794	lactate fermentation	100	4 of 4
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	suberin monomers biosynthesis	100	2 of 2
66794	ceramide biosynthesis	100	1 of 1
66794	folate polyglutamylation	100	1 of 1
66794	threonine metabolism	90	9 of 10
66794	starch degradation	90	9 of 10
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	glycolysis	88.24	15 of 17
66794	degradation of sugar alcohols	81.25	13 of 16
66794	peptidoglycan biosynthesis	80	12 of 15
66794	cellulose degradation	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	phenylalanine metabolism	76.92	10 of 13
66794	glycogen biosynthesis	75	3 of 4
66794	ppGpp biosynthesis	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	gluconeogenesis	75	6 of 8
66794	cardiolipin biosynthesis	71.43	5 of 7
66794	propanol degradation	71.43	5 of 7
66794	methane metabolism	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	degradation of hexoses	66.67	12 of 18
66794	serine metabolism	66.67	6 of 9
66794	octane oxidation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	CO2 fixation in Crenarchaeota	66.67	6 of 9
66794	d-mannose degradation	66.67	6 of 9
66794	purine metabolism	65.96	62 of 94
66794	degradation of pentoses	64.29	18 of 28
66794	isoleucine metabolism	62.5	5 of 8
66794	pyrimidine metabolism	62.22	28 of 45
66794	leucine metabolism	61.54	8 of 13
66794	glutamate and glutamine metabolism	60.71	17 of 28
66794	Entner Doudoroff pathway	60	6 of 10
66794	myo-inositol biosynthesis	60	6 of 10
66794	propionate fermentation	60	6 of 10
66794	glycine betaine biosynthesis	60	3 of 5
66794	methylglyoxal degradation	60	3 of 5
66794	methionine metabolism	57.69	15 of 26
66794	oxidative phosphorylation	57.14	52 of 91
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	non-pathway related	55.26	21 of 38
66794	vitamin B6 metabolism	54.55	6 of 11
66794	proline metabolism	54.55	6 of 11
66794	pentose phosphate pathway	54.55	6 of 11
66794	vitamin B1 metabolism	53.85	7 of 13
66794	alanine metabolism	51.72	15 of 29
66794	citric acid cycle	50	7 of 14
66794	toluene degradation	50	2 of 4
66794	acetate fermentation	50	2 of 4
66794	kanosamine biosynthesis II	50	1 of 2
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	50	4 of 8
66794	CMP-KDO biosynthesis	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	glycolate and glyoxylate degradation	50	3 of 6
66794	isoprenoid biosynthesis	50	13 of 26
66794	cysteine metabolism	50	9 of 18
66794	ketogluconate metabolism	50	4 of 8
66794	coenzyme A metabolism	50	2 of 4
66794	butanoate fermentation	50	2 of 4
66794	histidine metabolism	48.28	14 of 29
66794	tryptophan metabolism	44.74	17 of 38
66794	ubiquinone biosynthesis	42.86	3 of 7
66794	lipid metabolism	41.94	13 of 31
66794	lysine metabolism	40.48	17 of 42
66794	metabolism of amino sugars and derivatives	40	2 of 5
66794	arachidonate biosynthesis	40	2 of 5
66794	glycine metabolism	40	4 of 10
66794	bacilysin biosynthesis	40	2 of 5
66794	dTDPLrhamnose biosynthesis	37.5	3 of 8
66794	metabolism of disaccharids	36.36	4 of 11
66794	tyrosine metabolism	35.71	5 of 14
66794	tetrahydrofolate metabolism	35.71	5 of 14
66794	IAA biosynthesis	33.33	1 of 3
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	degradation of aromatic, nitrogen containing compounds	33.33	4 of 12
66794	sphingosine metabolism	33.33	2 of 6
66794	molybdenum cofactor biosynthesis	33.33	3 of 9
66794	cyanate degradation	33.33	1 of 3
66794	arginine metabolism	33.33	8 of 24
66794	1,4-dihydroxy-6-naphthoate biosynthesis	33.33	2 of 6
66794	nitrate assimilation	33.33	3 of 9
66794	lipid A biosynthesis	33.33	3 of 9
66794	degradation of sugar acids	32	8 of 25
66794	ascorbate metabolism	31.82	7 of 22
66794	urea cycle	30.77	4 of 13
66794	coenzyme M biosynthesis	30	3 of 10
66794	benzoyl-CoA degradation	28.57	2 of 7
66794	flavin biosynthesis	26.67	4 of 15
66794	androgen and estrogen metabolism	25	4 of 16
66794	carnitine metabolism	25	2 of 8
66794	cyclohexanol degradation	25	1 of 4
66794	phenylpropanoid biosynthesis	23.08	3 of 13
66794	sulfate reduction	23.08	3 of 13
66794	4-hydroxymandelate degradation	22.22	2 of 9
66794	glutathione metabolism	21.43	3 of 14

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body-Site	#Oral cavity and airways	#Mouth
#Host Body-Site	#Other	#Wound

Isolation

@ref	Sample type	Host species	Country	Country ISO 3 Code	Continent	Isolation date
19045	human periodontal lesions	Homo sapiens	Switzerland	CHE	Europe
120773	Subgingival plaque		Switzerland	CHE	Europe	1992

Taxonmaps

69479

Global distribution of 16S sequence X87140 (>99% sequence identity) for Treponema maltophilum subclade from Microbeatlas

Aquatic Samples	60
Soil Samples	32
Animal Samples	2778
Plant Samples	19
Total Samples	2889

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
19045	2	Risk group (German classification) According to TRBA 466
120773	2	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Trep_malt_ATCC_51939_V1 assembly for Treponema maltophilum ATCC 51939	scaffold	GCA_000413055	1125699.8	2541046974	1125699	77.9
66792	Treponema maltophilum ATCC 51939	contig		1125699.3		1125699	39

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
19045	Treponema maltophilum 16S rRNA gene (patient BR)	X87140	1497		51160

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Trep_malt_ATCC_51939_V1 assembly for Treponema maltophilum ATCC 51939
NCBI: GCA_000413055

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	92.19	no
125439	motility	BacteriaNetⓘ	no	81.97	no
125439	gram_stain	BacteriaNetⓘ	negative	98.30	no
125439	spore_formation	BacteriaNetⓘ	no	99.84	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Treponema maltophilum ATCC 51939 ATCC 51939
NCBI: GCA_000413055.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	87.79	no
125438	anaerobic	anaerobicⓘ	yes	90.93	yes
125438	aerobic	aerobicⓘ	no	97.11	yes
125438	spore-forming	spore-formingⓘ	no	78.26	no
125438	thermophilic	thermophileⓘ	no	87.70	no
125438	flagellated	motile2+ⓘ	yes	57.77	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Phylogeny	Diversity of Treponema denticola and Other Oral Treponeme Lineages in Subjects with Periodontitis and Gingivitis.	Zeng H, Chan Y, Gao W, Leung WK, Watt RM.	Microbiol Spectr	10.1128/spectrum.00701-21	2021
Phylogeny	Identification of seven Treponema species in health- and disease-associated dental plaque by nested PCR.	Willis SG, Smith KS, Dunn VL, Gapter LA, Riviere KH, Riviere GR.	J Clin Microbiol	10.1128/jcm.37.3.867-869.1999	1999
Metabolism	Phyloproteomic and functional analyses do not support a split in the genus Borrelia (phylum Spirochaetes).	Estrada-Pena A, Cabezas-Cruz A.	BMC Evol Biol	10.1186/s12862-019-1379-2	2019
	Upregulation of intercellular adhesion molecule 1 and proinflammatory cytokines by the major surface proteins of Treponema maltophilum and Treponema lecithinolyticum, the phylogenetic group IV oral spirochetes associated with periodontitis and endodontic infections.	Lee SH, Kim KK, Choi BK.	Infect Immun	10.1128/iai.73.1.268-276.2005	2005
	Analysis of the complement sensitivity of oral treponemes and the potential influence of FH binding, FH cleavage and dentilisin activity on the pathogenesis of periodontal disease.	Miller DP, McDowell JV, Bell JK, Goetting-Minesky MP, Fenno JC, Marconi RT.	Mol Oral Microbiol	10.1111/omi.12054	2014
Metabolism	A flagellar gene cluster from the oral spirochaete Treponema maltophilum.	Heuner K, Grosse K, Schade R, Gobel UB	Microbiology (Reading)	10.1099/00221287-146-2-497	2000
Enzymology	Cloning and characterization of a gene (mspA) encoding the major sheath protein of Treponema maltophilum ATCC 51939(T).	Heuner K, Choi BK, Schade R, Moter A, Otto A, Gobel UB	J Bacteriol	10.1128/JB.181.3.1025-1029.1999	1999

References

#19045	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 27366
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#37205	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120773	Collection of Institut Pasteur ; Curators of the CIP; CIP 105146
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Treponema maltophilum (DSM 27366, ATCC 51939, CIP 105146)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Pathway annotation

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000413055

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

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