Pathogenicity |
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium. |
Stabler RA, He M, Dawson L, Martin M, Valiente E, Corton C, Lawley TD, Sebaihia M, Quail MA, Rose G, Gerding DN, Gibert M, Popoff MR, Parkhill J, Dougan G, Wren BW |
Genome Biol |
10.1186/gb-2009-10-9-r102 |
2009 |
* |
Pathogenicity |
SleC is essential for germination of Clostridium difficile spores in nutrient-rich medium supplemented with the bile salt taurocholate. |
Burns DA, Heap JT, Minton NP |
J Bacteriol |
10.1128/JB.01209-09 |
2009 |
* |
Pathogenicity |
A mariner-based transposon system for in vivo random mutagenesis of Clostridium difficile. |
Cartman ST, Minton NP |
Appl Environ Microbiol |
10.1128/AEM.02525-09 |
2009 |
* |
Pathogenicity |
Infection of hamsters with the UK Clostridium difficile ribotype 027 outbreak strain R20291. |
Buckley AM, Spencer J, Candlish D, Irvine JJ, Douce GR |
J Med Microbiol |
10.1099/jmm.0.028514-0 |
2011 |
* |
Pathogenicity |
Efficacy of "sporicidal" wipes against Clostridium difficile. |
Siani H, Cooper C, Maillard JY |
Am J Infect Control |
10.1016/j.ajic.2011.01.006 |
2011 |
* |
Metabolism |
The analysis of para-cresol production and tolerance in Clostridium difficile 027 and 012 strains. |
Dawson LF, Donahue EH, Cartman ST, Barton RH, Bundy J, McNerney R, Minton NP, Wren BW |
BMC Microbiol |
10.1186/1471-2180-11-86 |
2011 |
* |
Pathogenicity |
Genetic organisation, mobility and predicted functions of genes on integrated, mobile genetic elements in sequenced strains of Clostridium difficile. |
Brouwer MS, Warburton PJ, Roberts AP, Mullany P, Allan E |
PLoS One |
10.1371/journal.pone.0023014 |
2011 |
* |
Phylogeny |
Behavior and target site selection of conjugative transposon Tn916 in two different strains of toxigenic Clostridium difficile. |
Mullany P, Williams R, Langridge GC, Turner DJ, Whalan R, Clayton C, Lawley T, Hussain H, McCurrie K, Morden N, Allan E, Roberts AP |
Appl Environ Microbiol |
10.1128/AEM.06193-11 |
2012 |
* |
Genetics |
Precise manipulation of the Clostridium difficile chromosome reveals a lack of association between the tcdC genotype and toxin production. |
Cartman ST, Kelly ML, Heeg D, Heap JT, Minton NP |
Appl Environ Microbiol |
10.1128/AEM.00249-12 |
2012 |
* |
Pathogenicity |
Multiple factors modulate biofilm formation by the anaerobic pathogen Clostridium difficile. |
Ethapa T, Leuzzi R, Ng YK, Baban ST, Adamo R, Kuehne SA, Scarselli M, Minton NP, Serruto D, Unnikrishnan M |
J Bacteriol |
10.1128/JB.01980-12 |
2012 |
* |
Genetics |
Expanding the repertoire of gene tools for precise manipulation of the Clostridium difficile genome: allelic exchange using pyrE alleles. |
Ng YK, Ehsaan M, Philip S, Collery MM, Janoir C, Collignon A, Cartman ST, Minton NP |
PLoS One |
10.1371/journal.pone.0056051 |
2013 |
* |
Pathogenicity |
Clostridium-DT(DB): a comprehensive database for potential drug targets of Clostridium difficile. |
Jadhav A, Ezhilarasan V, Prakash Sharma O, Pan A |
Comput Biol Med |
10.1016/j.compbiomed.2013.01.009 |
2013 |
* |
Genetics |
The agr locus regulates virulence and colonization genes in Clostridium difficile 027. |
Martin MJ, Clare S, Goulding D, Faulds-Pain A, Barquist L, Browne HP, Pettit L, Dougan G, Lawley TD, Wren BW |
J Bacteriol |
10.1128/JB.00473-13 |
2013 |
* |
Metabolism |
The Clostridium difficile exosporium cysteine (CdeC)-rich protein is required for exosporium morphogenesis and coat assembly. |
Barra-Carrasco J, Olguin-Araneda V, Plaza-Garrido A, Miranda-Cardenas C, Cofre-Araneda G, Pizarro-Guajardo M, Sarker MR, Paredes-Sabja D |
J Bacteriol |
10.1128/JB.00369-13 |
2013 |
* |
Metabolism |
Clostridium difficile modulates host innate immunity via toxin-independent and dependent mechanism(s). |
Jafari NV, Kuehne SA, Bryant CE, Elawad M, Wren BW, Minton NP, Allan E, Bajaj-Elliott M |
PLoS One |
10.1371/journal.pone.0069846 |
2013 |
* |
Pathogenicity |
Importance of toxin A, toxin B, and CDT in virulence of an epidemic Clostridium difficile strain. |
Kuehne SA, Collery MM, Kelly ML, Cartman ST, Cockayne A, Minton NP |
J Infect Dis |
10.1093/infdis/jit426 |
2013 |
* |
Pathogenicity |
The role of flagella in Clostridium difficile pathogenesis: comparison between a non-epidemic and an epidemic strain. |
Baban ST, Kuehne SA, Barketi-Klai A, Cartman ST, Kelly ML, Hardie KR, Kansau I, Collignon A, Minton NP |
PLoS One |
10.1371/journal.pone.0073026 |
2013 |
* |
Metabolism |
Identification of a novel zinc metalloprotease through a global analysis of Clostridium difficile extracellular proteins. |
Cafardi V, Biagini M, Martinelli M, Leuzzi R, Rubino JT, Cantini F, Norais N, Scarselli M, Serruto D, Unnikrishnan M |
PLoS One |
10.1371/journal.pone.0081306 |
2013 |
* |
Metabolism |
The spore-associated protein BclA1 affects the susceptibility of animals to colonization and infection by Clostridium difficile. |
Phetcharaburanin J, Hong HA, Colenutt C, Bianconi I, Sempere L, Permpoonpattana P, Smith K, Dembek M, Tan S, Brisson MC, Brisson AR, Fairweather NF, Cutting SM |
Mol Microbiol |
10.1111/mmi.12611 |
2014 |
* |
Genetics |
Identification and characterization of glycoproteins on the spore surface of Clostridium difficile. |
Strong PC, Fulton KM, Aubry A, Foote S, Twine SM, Logan SM |
J Bacteriol |
10.1128/JB.01469-14 |
2014 |
* |
Metabolism |
The flagellin FliC of Clostridium difficile is responsible for pleiotropic gene regulation during in vivo infection. |
Barketi-Klai A, Monot M, Hoys S, Lambert-Bordes S, Kuehne SA, Minton N, Collignon A, Dupuy B, Kansau I |
PLoS One |
10.1371/journal.pone.0096876 |
2014 |
* |
Phenotype |
Comparative nutritional and chemical phenome of Clostridium difficile isolates determined using phenotype microarrays. |
Scaria J, Chen JW, Useh N, He H, McDonough SP, Mao C, Sobral B, Chang YF |
Int J Infect Dis |
10.1016/j.ijid.2014.06.018 |
2014 |
* |
Metabolism |
Global transcriptional response of Clostridium difficile carrying the CD38 prophage. |
Sekulovic O, Fortier LC |
Appl Environ Microbiol |
10.1128/AEM.03656-14 |
2015 |
* |
Pathogenicity |
High-throughput analysis of gene essentiality and sporulation in Clostridium difficile. |
Dembek M, Barquist L, Boinett CJ, Cain AK, Mayho M, Lawley TD, Fairweather NF, Fagan RP |
mBio |
10.1128/mBio.02383-14 |
2015 |
* |
Metabolism |
Observations on the Role of TcdE Isoforms in Clostridium difficile Toxin Secretion. |
Govind R, Fitzwater L, Nichols R |
J Bacteriol |
10.1128/JB.00224-15 |
2015 |
* |
Metabolism |
The Clostridium difficile cell wall protein CwpV confers phase-variable phage resistance. |
Sekulovic O, Ospina Bedoya M, Fivian-Hughes AS, Fairweather NF, Fortier LC |
Mol Microbiol |
10.1111/mmi.13121 |
2015 |
* |
Genetics |
Function of the CRISPR-Cas System of the Human Pathogen Clostridium difficile. |
Boudry P, Semenova E, Monot M, Datsenko KA, Lopatina A, Sekulovic O, Ospina-Bedoya M, Fortier LC, Severinov K, Dupuy B, Soutourina O |
mBio |
10.1128/mBio.01112-15 |
2015 |
* |
Metabolism |
Regulation of Type IV Pili Contributes to Surface Behaviors of Historical and Epidemic Strains of Clostridium difficile. |
Purcell EB, McKee RW, Bordeleau E, Burrus V, Tamayo R |
J Bacteriol |
10.1128/JB.00816-15 |
2015 |
* |
Pathogenicity |
The SOS Response Master Regulator LexA Is Associated with Sporulation, Motility and Biofilm Formation in Clostridium difficile. |
Walter BM, Cartman ST, Minton NP, Butala M, Rupnik M |
PLoS One |
10.1371/journal.pone.0144763 |
2015 |
* |
Pathogenicity |
Clostridium difficile-mediated effects on human intestinal epithelia: Modelling host-pathogen interactions in a vertical diffusion chamber. |
Jafari NV, Kuehne SA, Minton NP, Allan E, Bajaj-Elliott M |
Anaerobe |
10.1016/j.anaerobe.2015.12.007 |
2015 |
* |
Pathogenicity |
Impact on toxin production and cell morphology in Clostridium difficile by ridinilazole (SMT19969), a novel treatment for C. difficile infection. |
Basseres E, Endres BT, Khaleduzzaman M, Miraftabi F, Alam MJ, Vickers RJ, Garey KW |
J Antimicrob Chemother |
10.1093/jac/dkv498 |
2016 |
* |
Pathogenicity |
Improving the reproducibility of the NAP1/B1/027 epidemic strain R20291 in the hamster model of infection. |
Kelly ML, Ng YK, Cartman ST, Collery MM, Cockayne A, Minton NP |
Anaerobe |
10.1016/j.anaerobe.2016.02.011 |
2016 |
* |
Phylogeny |
Isolation of recombinant antibodies directed against surface proteins of Clostridium difficile. |
Shirvan AN, Aitken R |
Braz J Microbiol |
10.1016/j.bjm.2016.01.017 |
2016 |
* |
Pathogenicity |
Evaluating the Effects of Surotomycin Treatment on Clostridium difficile Toxin A and B Production, Immune Response, and Morphological Changes. |
Endres BT, Basseres E, Khaleduzzaman M, Alam MJ, Chesnel L, Garey KW |
Antimicrob Agents Chemother |
10.1128/AAC.00211-16 |
2016 |
* |
Transcriptome |
Deciphering Adaptation Strategies of the Epidemic Clostridium difficile 027 Strain during Infection through In Vivo Transcriptional Analysis. |
Kansau I, Barketi-Klai A, Monot M, Hoys S, Dupuy B, Janoir C, Collignon A |
PLoS One |
10.1371/journal.pone.0158204 |
2016 |
* |
Metabolism |
Heat shock increases conjugation efficiency in Clostridium difficile. |
Kirk JA, Fagan RP |
Anaerobe |
10.1016/j.anaerobe.2016.06.009 |
2016 |
* |
Phylogeny |
Nosocomial transmission of Clostridium difficile ribotype 027 in a Chinese hospital, 2012-2014, traced by whole genome sequencing. |
Jia H, Du P, Yang H, Zhang Y, Wang J, Zhang W, Han G, Han N, Yao Z, Wang H, Zhang J, Wang Z, Ding Q, Qiang Y, Barbut F, Gao GF, Cao Y, Cheng Y, Chen C |
BMC Genomics |
10.1186/s12864-016-2708-0 |
2016 |
* |
Metabolism |
Crystal structures of two nitroreductases from hypervirulent Clostridium difficile and functionally related interactions with the antibiotic metronidazole. |
Wang B, Powell SM, Hessami N, Najar FZ, Thomas LM, Karr EA, West AH, Richter-Addo GB |
Nitric Oxide |
10.1016/j.niox.2016.09.003 |
2016 |
* |
Metabolism |
Characterization of the Adherence of Clostridium difficile Spores: The Integrity of the Outermost Layer Affects Adherence Properties of Spores of the Epidemic Strain R20291 to Components of the Intestinal Mucosa. |
Mora-Uribe P, Miranda-Cardenas C, Castro-Cordova P, Gil F, Calderon I, Fuentes JA, Rodas PI, Banawas S, Sarker MR, Paredes-Sabja D |
Front Cell Infect Microbiol |
10.3389/fcimb.2016.00099 |
2016 |
* |
Metabolism |
Crystal structure and DNA binding activity of a PadR family transcription regulator from hypervirulent Clostridium difficile R20291. |
Isom CE, Menon SK, Thomas LM, West AH, Richter-Addo GB, Karr EA |
BMC Microbiol |
10.1186/s12866-016-0850-0 |
2016 |
* |
Stress |
Chemical and Stress Resistances of Clostridium difficile Spores and Vegetative Cells. |
Edwards AN, Karim ST, Pascual RA, Jowhar LM, Anderson SE, McBride SM |
Front Microbiol |
10.3389/fmicb.2016.01698 |
2016 |
* |
Enzymology |
Characterization of the Clostridium difficile volatile metabolome using comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry. |
Rees CA, Shen A, Hill JE |
J Chromatogr B Analyt Technol Biomed Life Sci |
10.1016/j.jchromb.2016.11.009 |
2016 |
* |
Pathogenicity |
Cefoperazone-treated Mouse Model of Clinically-relevant Clostridium difficile Strain R20291. |
Winston JA, Thanissery R, Montgomery SA, Theriot CM |
J Vis Exp |
10.3791/54850 |
2016 |
* |
Pathogenicity |
Evolutionary clade affects resistance of Clostridium difficile spores to Cold Atmospheric Plasma. |
Connor M, Flynn PB, Fairley DJ, Marks N, Manesiotis P, Graham WG, Gilmore BF, McGrath JW |
Sci Rep |
10.1038/srep41814 |
2017 |
* |
Pathogenicity |
Making life difficult for Clostridium difficile: augmenting the pathogen's metabolic model with transcriptomic and codon usage data for better therapeutic target characterization. |
Kashaf SS, Angione C, Lio P |
BMC Syst Biol |
10.1186/s12918-017-0395-3 |
2017 |
* |
Genetics |
The challenge of detecting indels in bacterial genomes from short-read sequencing data. |
Steglich M, Nubel U |
J Biotechnol |
10.1016/j.jbiotec.2017.02.026 |
2017 |
* |
Pathogenicity |
Inhibition of spore germination, growth, and toxin activity of clinically relevant C. difficile strains by gut microbiota derived secondary bile acids. |
Thanissery R, Winston JA, Theriot CM |
Anaerobe |
10.1016/j.anaerobe.2017.03.004 |
2017 |
* |
Pathogenicity |
Survival of Clostridium difficile spores at low water activity. |
Deng K, Talukdar PK, Sarker MR, Paredes-Sabja D, Torres JA |
Food Microbiol |
10.1016/j.fm.2017.03.013 |
2017 |
* |
Pathogenicity |
A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment. |
Endres B, Basseres E, Rashid T, Chang L, Alam MJ, Garey KW |
J Vis Exp |
10.3791/55383 |
2017 |
* |
Metabolism |
High metabolic versatility of different toxigenic and non-toxigenic Clostridioides difficile isolates. |
Riedel T, Wetzel D, Hofmann JD, Plorin SPEO, Dannheim H, Berges M, Zimmermann O, Bunk B, Schober I, Sproer C, Liesegang H, Jahn D, Overmann J, Gross U, Neumann-Schaal M |
Int J Med Microbiol |
10.1016/j.ijmm.2017.05.007 |
2017 |
* |
Pathogenicity |
Characterization of Chicken IgY Specific to Clostridium difficile R20291 Spores and the Effect of Oral Administration in Mouse Models of Initiation and Recurrent Disease. |
Pizarro-Guajardo M, Diaz-Gonzalez F, Alvarez-Lobos M, Paredes-Sabja D |
Front Cell Infect Microbiol |
10.3389/fcimb.2017.00365 |
2017 |
* |
Pathogenicity |
Characterization of the impact of rpoB mutations on the in vitro and in vivo competitive fitness of Clostridium difficile and susceptibility to fidaxomicin. |
Kuehne SA, Dempster AW, Collery MM, Joshi N, Jowett J, Kelly ML, Cave R, Longshaw CM, Minton NP |
J Antimicrob Chemother |
10.1093/jac/dkx486 |
2018 |
* |
Metabolism |
Pleiotropic roles of Clostridium difficile sin locus. |
Girinathan BP, Ou J, Dupuy B, Govind R |
PLoS Pathog |
10.1371/journal.ppat.1006940 |
2018 |
* |
Enzymology |
Identification of Clostridium difficile Immunoreactive Spore Proteins of the Epidemic Strain R20291. |
Pizarro-Guajardo M, Ravanal MC, Paez MD, Callegari E, Paredes-Sabja D |
Proteomics Clin Appl |
10.1002/prca.201700182 |
2018 |
* |
Metabolism |
Characterization of Flagellum and Toxin Phase Variation in Clostridioides difficile Ribotype 012 Isolates. |
Anjuwon-Foster BR, Maldonado-Vazquez N, Tamayo R |
J Bacteriol |
10.1128/JB.00056-18 |
2018 |
* |
Biotechnology |
Convergent Loss of ABC Transporter Genes From Clostridioides difficile Genomes Is Associated With Impaired Tyrosine Uptake and p-Cresol Production. |
Steglich M, Hofmann JD, Helmecke J, Sikorski J, Sproer C, Riedel T, Bunk B, Overmann J, Neumann-Schaal M, Nubel U |
Front Microbiol |
10.3389/fmicb.2018.00901 |
2018 |
* |
Pathogenicity |
The Design, Synthesis, and Characterizations of Spore Germination Inhibitors Effective against an Epidemic Strain of Clostridium difficile. |
Sharma SK, Yip C, Esposito EX, Sharma PV, Simon MP, Abel-Santos E, Firestine SM |
J Med Chem |
10.1021/acs.jmedchem.8b00632 |
2018 |
* |
Metabolism |
Time-resolved transcriptome analysis of Clostridium difficile R20291 response to cysteine. |
Gu H, Shi K, Liao Z, Qi H, Chen S, Wang H, Li S, Ma Y, Wang J |
Microbiol Res |
10.1016/j.micres.2018.07.003 |
2018 |
* |
Metabolism |
Regulatory Targets of the Response Regulator RR_1586 from Clostridioides difficile Identified Using a Bacterial One-Hybrid Screen. |
Hebdon SD, Menon SK, Richter-Addo GB, Karr EA, West AH |
J Bacteriol |
10.1128/JB.00351-18 |
2018 |
* |
Pathogenicity |
Characterization of the virulence of a non-RT027, non-RT078 and binary toxin-positive Clostridium difficile strain associated with severe diarrhea. |
Li C, Harmanus C, Zhu D, Meng X, Wang S, Duan J, Liu S, Fu C, Zhou P, Liu R, Wu A, Kuijper EJ, Smits WK, Fu L, Sun X |
Emerg Microbes Infect |
10.1038/s41426-018-0211-1 |
2018 |
* |
Metabolism |
Cwp22, a novel peptidoglycan cross-linking enzyme, plays pleiotropic roles in Clostridioides difficile. |
Zhu D, Bullock J, He Y, Sun X |
Environ Microbiol |
10.1111/1462-2920.14706 |
2019 |
* |
Pathogenicity |
Interlaboratory reproducibility of a test method following 4-field test methodology to evaluate the susceptibility of Clostridium difficile spores. |
Gemein S, Gebel J, Christiansen B, Martiny H, Vossebein L, Brill FHH, Decius M, Eggers M, Koburger-Janssen T, Meckel M, Werner S, Hunsinger B, Selhorst T, Kampf G, Exner M |
J Hosp Infect |
10.1016/j.jhin.2019.04.011 |
2019 |
* |
Pathogenicity |
Phenotypic characterisation of Clostridium difficile PCR ribotype 251, an emerging multi-locus sequence type clade 2 strain in Australia. |
Hong S, Knight DR, Chang B, Carman RJ, Riley TV |
Anaerobe |
10.1016/j.anaerobe.2019.06.019 |
2019 |
* |
Pathogenicity |
Single cell analysis of nutrient regulation of Clostridioides (Clostridium) difficile motility. |
Courson DS, Pokhrel A, Scott C, Madrill M, Rinehold AJ, Tamayo R, Cheney RE, Purcell EB |
Anaerobe |
10.1016/j.anaerobe.2019.102080 |
2019 |
* |
Metabolism |
Strain-Dependent RstA Regulation of Clostridioides difficile Toxin Production and Sporulation. |
Edwards AN, Krall EG, McBride SM |
J Bacteriol |
10.1128/JB.00586-19 |
2020 |
* |
Metabolism |
The Transcriptional Regulator Lrp Contributes to Toxin Expression, Sporulation, and Swimming Motility in Clostridium difficile. |
Chen KY, Rathod J, Chiu YC, Chen JW, Tsai PJ, Huang IH |
Front Cell Infect Microbiol |
10.3389/fcimb.2019.00356 |
2019 |
* |
Physiology |
The Impact of pH on Clostridioides difficile Sporulation and Physiology. |
Wetzel D, McBride SM |
Appl Environ Microbiol |
10.1128/AEM.02706-19 |
2020 |
* |
Pathogenicity |
Effect of antibiotic to induce Clostridioides difficile-susceptibility and infectious strain in a mouse model of Clostridioides difficile infection and recurrence. |
Castro-Cordova P, Diaz-Yanez F, Munoz-Miralles J, Gil F, Paredes-Sabja D |
Anaerobe |
10.1016/j.anaerobe.2020.102149 |
2020 |
* |
Biotechnology |
In vitro Production and Immunogenicity of a Clostridium Difficile Spore-Specific BclA3 Glycopeptide Conjugate Vaccine. |
Aubry A, Zou W, Vinogradov E, Williams D, Chen W, Harris G, Zhou H, Schur MJ, Gilbert M, Douce GR, Logan SM |
Vaccines (Basel) |
10.3390/vaccines8010073 |
2020 |
* |
Phylogeny |
Origin, genomic diversity and microevolution of the Clostridium difficile B1/NAP1/RT027/ST01 strain in Costa Rica, Chile, Honduras and Mexico. |
Guerrero-Araya E, Meneses C, Castro-Nallar E, Guzman D AM, Alvarez-Lobos M, Quesada-Gomez C, Paredes-Sabja D, Rodriguez C |
Microb Genom |
10.1099/mgen.0.000355 |
2020 |
* |
Pathogenicity |
Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids. |
Winston JA, Rivera AJ, Cai J, Thanissery R, Montgomery SA, Patterson AD, Theriot CM |
Infect Immun |
10.1128/IAI.00045-20 |
2020 |
* |
Metabolism |
Characterization of Clostridioides difficile DSM 101085 with A-B-CDT+ Phenotype from a Late Recurrent Colonization. |
Riedel T, Neumann-Schaal M, Wittmann J, Schober I, Hofmann JD, Lu CW, Dannheim A, Zimmermann O, Lochner M, Gross U, Overmann J |
Genome Biol Evol |
10.1093/gbe/evaa072 |
2020 |
* |
Metabolism |
Evaluation of functionality of type II toxin-antitoxin systems of Clostridioides difficile R20291. |
Alvarez R, Ortega-Fuentes C, Queralto C, Inostroza O, Diaz-Yanez F, Gonzalez R, Calderon IL, Fuentes JA, Paredes-Sabja D, Gil F |
Microbiol Res |
10.1016/j.micres.2020.126539 |
2020 |
* |
Pathogenicity |
The (p)ppGpp Synthetase RSH Mediates Stationary-Phase Onset and Antibiotic Stress Survival in Clostridioides difficile. |
Pokhrel A, Poudel A, Castro KB, Celestine MJ, Oludiran A, Rinehold AJ, Resek AM, Mhanna MA, Purcell EB |
J Bacteriol |
10.1128/JB.00377-20 |
2020 |
* |
Metabolism |
Spo0A Suppresses sin Locus Expression in Clostridioides difficile. |
Dhungel BA, Govind R |
mSphere |
10.1128/mSphere.00963-20 |
2020 |
* |
Metabolism |
Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive. |
Henkel D, Tatge H, Schottelndreier D, Tao L, Dong M, Gerhard R |
Toxins (Basel) |
10.3390/toxins12120736 |
2020 |
* |
Pathogenicity |
The Acid-Dependent and Independent Effects of Lactobacillus acidophilus CL1285, Lacticaseibacillus casei LBC80R, and Lacticaseibacillus rhamnosus CLR2 on Clostridioides difficile R20291. |
Gunaratnam S, Diarra C, Paquette PD, Ship N, Millette M, Lacroix M |
Probiotics Antimicrob Proteins |
10.1007/s12602-020-09729-5 |
2021 |
* |
Metabolism |
Extracellular DNA, cell surface proteins and c-di-GMP promote biofilm formation in Clostridioides difficile. |
Dawson LF, Peltier J, Hall CL, Harrison MA, Derakhshan M, Shaw HA, Fairweather NF, Wren BW |
Sci Rep |
10.1038/s41598-020-78437-5 |
2021 |
* |
Phylogeny |
Molecular characterization of Clostridioides difficile ribotype 027 in a major Chinese hospital. |
Zhang RF, Man YX, Bai YY, Shao CH, Liu CM, Wang CH, Lei YX, Wang Y, Jin Y |
J Microbiol Immunol Infect |
10.1016/j.jmii.2021.01.003 |
2021 |
* |
Pathogenicity |
Cwl0971, a novel peptidoglycan hydrolase, plays pleiotropic roles in Clostridioides difficile R20291. |
Zhu D, Patabendige HMLW, Tomlinson BR, Wang S, Hussain S, Flores D, He Y, Shaw LN, Sun X |
Environ Microbiol |
10.1111/1462-2920.15529 |
2021 |
* |
Phylogeny |
What's a SNP between friends: The lineage of Clostridioides difficile R20291 can effect research outcomes. |
Monteford J, Bilverstone TW, Ingle P, Philip S, Kuehne SA, Minton NP |
Anaerobe |
10.1016/j.anaerobe.2021.102422 |
2021 |
* |
Metabolism |
Ebselen Not Only Inhibits Clostridioides difficile Toxins but Displays Redox-Associated Cellular Killing. |
Marreddy RKR, Olaitan AO, May JN, Dong M, Hurdle JG |
Microbiol Spectr |
10.1128/Spectrum.00448-21 |
2021 |
* |
Pathogenicity |
Biofilm regulation in Clostridioides difficile: Novel systems linked to hypervirulence. |
Taggart MG, Snelling WJ, Naughton PJ, La Ragione RM, Dooley JSG, Ternan NG |
PLoS Pathog |
10.1371/journal.ppat.1009817 |
2021 |
* |
Physiology |
FliW and CsrA Govern Flagellin (FliC) Synthesis and Play Pleiotropic Roles in Virulence and Physiology of Clostridioides difficile R20291. |
Zhu D, Wang S, Sun X |
Front Microbiol |
10.3389/fmicb.2021.735616 |
2021 |
* |
Physiology |
Impact of Phage CDHS-1 on the Transcription, Physiology and Pathogenicity of a Clostridioides difficile Ribotype 027 Strain, R20291. |
Nale JY, Al-Tayawi TS, Heaphy S, Clokie MRJ |
Viruses |
10.3390/v13112262 |
2021 |
* |
Pathogenicity |
Studies on the Importance of the 7alpha-, and 12alpha- hydroxyl groups of N-Aryl-3alpha,7alpha,12alpha-trihydroxy-5beta-cholan-24-amides on their Antigermination Activity Against a Hypervirulent Strain of Clostridioides (Clostridium) difficile. |
Sharma SK, Yip C, Simon MP, Phan J, Abel-Santos E, Firestine SM |
Bioorg Med Chem |
10.1016/j.bmc.2021.116503 |
2021 |
* |
Metabolism |
c-di-GMP Inhibits Early Sporulation in Clostridioides difficile. |
Edwards AN, Willams CL, Pareek N, McBride SM, Tamayo R |
mSphere |
10.1128/msphere.00919-21 |
2021 |
* |
Metabolism |
Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization. |
Pruss KM, Enam F, Battaglioli E, DeFeo M, Diaz OR, Higginbottom SK, Fischer CR, Hryckowian AJ, Van Treuren W, Dodd D, Kashyap P, Sonnenburg JL |
Nat Metab |
10.1038/s42255-021-00506-4 |
2022 |
* |
Pathogenicity |
Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection. |
Peritore-Galve FC, Shupe JA, Cave RJ, Childress KO, Washington MK, Kuehne SA, Lacy DB |
PLoS Pathog |
10.1371/journal.ppat.1010323 |
2022 |
* |
Metabolism |
Flagellum and toxin phase variation impacts intestinal colonization and disease development in a mouse model of Clostridioides difficile infection. |
Trzilova D, Warren MAH, Gadda NC, Williams CL, Tamayo R |
Gut Microbes |
10.1080/19490976.2022.2038854 |
2022 |
* |
Pathogenicity |
Genomic and Phenotypic Characterization of the Nontoxigenic Clostridioides difficile Strain CCUG37785 and Demonstration of Its Therapeutic Potential for the Prevention of C. difficile Infection. |
Wang S, Heuler J, Wickramage I, Sun X |
Microbiol Spectr |
10.1128/spectrum.01788-21 |
2022 |
* |
Metabolism |
Response Regulator CD1688 Is a Negative Modulator of Sporulation in Clostridioides difficile. |
Kempher ML, Morris SC, Shadid TM, Menon SK, Ballard JD, West AH |
J Bacteriol |
10.1128/jb.00130-22 |
2022 |
* |
Pathogenicity |
d-Proline Reductase Underlies Proline-Dependent Growth of Clostridioides difficile. |
Johnstone MA, Self WT |
J Bacteriol |
10.1128/jb.00229-22 |
2022 |
* |
|
Demonstration of conjugative transposon (Tn5397)-mediated horizontal gene transfer between Clostridium difficile and Enterococcus faecalis. |
Jasni AS, Mullany P, Hussain H, Roberts AP |
Antimicrob Agents Chemother |
10.1128/AAC.00496-10 |
2010 |
* |
|
In-depth genetic analysis of Clostridium difficile PCR-ribotype 027 strains reveals high genome fluidity including point mutations and inversions. |
Stabler RA, Valiente E, Dawson LF, He M, Parkhill J, Wren BW |
Gut Microbes |
10.4161/gmic.1.4.11870 |
2010 |
* |
|
Characterisation of Clostridium difficile biofilm formation, a role for Spo0A. |
Dawson LF, Valiente E, Faulds-Pain A, Donahue EH, Wren BW |
PLoS One |
10.1371/journal.pone.0050527 |
2012 |
* |
|
Identification, immunogenicity, and cross-reactivity of type IV pilin and pilin-like proteins from Clostridium difficile. |
Maldarelli GA, De Masi L, von Rosenvinge EC, Carter M, Donnenberg MS |
Pathog Dis |
10.1111/2049-632X.12137 |
2014 |
* |
|
Survival of Clostridium difficile spores at low temperatures. |
Deng K, Plaza-Garrido A, Torres JA, Paredes-Sabja D |
Food Microbiol |
10.1016/j.fm.2014.07.022 |
2014 |
* |
|
Effect of tcdR Mutation on Sporulation in the Epidemic Clostridium difficile Strain R20291. |
Girinathan BP, Monot M, Boyle D, McAllister KN, Sorg JA, Dupuy B, Govind R |
mSphere |
10.1128/mSphere.00383-16 |
2017 |
* |
|
Biofilm Structures in a Mono-Associated Mouse Model of Clostridium difficile Infection. |
Soavelomandroso AP, Gaudin F, Hoys S, Nicolas V, Vedantam G, Janoir C, Bouttier S |
Front Microbiol |
10.3389/fmicb.2017.02086 |
2017 |
* |
|
Comparative genomic analysis of Clostridium difficile ribotype 027 strains including the newly sequenced strain NCKUH-21 isolated from a patient in Taiwan. |
Suzuki H, Tomita M, Tsai PJ, Ko WC, Hung YP, Huang IH, Chen JW |
Gut Pathog |
10.1186/s13099-017-0219-4 |
2017 |
* |
|
A Small Molecule-Screening Pipeline to Evaluate the Therapeutic Potential of 2-Aminoimidazole Molecules Against Clostridium difficile. |
Thanissery R, Zeng D, Doyle RG, Theriot CM |
Front Microbiol |
10.3389/fmicb.2018.01206 |
2018 |
* |
|
The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding. |
Chung SY, Schottelndreier D, Tatge H, Fuhner V, Hust M, Beer LA, Gerhard R |
Front Microbiol |
10.3389/fmicb.2018.02314 |
2018 |
* |
|
Using an Endogenous CRISPR-Cas System for Genome Editing in the Human Pathogen Clostridium difficile. |
Maikova A, Kreis V, Boutserin A, Severinov K, Soutourina O |
Appl Environ Microbiol |
10.1128/AEM.01416-19 |
2019 |
* |
|
Hypervirulent clade 2, ribotype 019/sequence type 67 Clostridioides difficile strain from Japan. |
Saito R, Usui Y, Ayibieke A, Nakajima J, Prah I, Sonobe K, Aiso Y, Ito S, Itsui Y, Hadano Y, Nukui Y, Koike R, Tohda S |
Gut Pathog |
10.1186/s13099-019-0336-3 |
2019 |
* |
|
A High-Fat/High-Protein, Atkins-Type Diet Exacerbates Clostridioides (Clostridium) difficile Infection in Mice, whereas a High-Carbohydrate Diet Protects. |
Mefferd CC, Bhute SS, Phan JR, Villarama JV, Do DM, Alarcia S, Abel-Santos E, Hedlund BP |
mSystems |
10.1128/mSystems.00765-19 |
2020 |
* |
|
Characterization of Exosporium Layer Variability of Clostridioides difficile Spores in the Epidemically Relevant Strain R20291. |
Pizarro-Guajardo M, Calderon-Romero P, Romero-Rodriguez A, Paredes-Sabja D |
Front Microbiol |
10.3389/fmicb.2020.01345 |
2020 |
* |
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Novel Drivers of Virulence in Clostridioides difficile Identified via Context-Specific Metabolic Network Analysis. |
Jenior ML, Leslie JL, Powers DA, Garrett EM, Walker KA, Dickenson ME, Petri WA Jr, Tamayo R, Papin JA |
mSystems |
10.1128/mSystems.00919-21 |
2021 |
* |
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An Aniline-Substituted Bile Salt Analog Protects both Mice and Hamsters from Multiple Clostridioides difficile Strains. |
Phan JR, Do DM, Truong MC, Ngo C, Phan JH, Sharma SK, Schilke A, Mefferd CC, Villarama JV, Lai D, Consul A, Hedlund BP, Firestine SM, Abel-Santos E |
Antimicrob Agents Chemother |
10.1128/AAC.01435-21 |
2021 |
* |