Burkholderia dolosa (DSM 16088, CCUG 47727, LMG 18943)

Name: Burkholderia dolosa (DSM 16088, CCUG 47727, LMG 18943)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 1947

Type strain

Strain Designation AU0645, R-5670

Culture col. no. DSM 16088 CCUG 47727 LMG 18943 AU0645 R-5670 1 more

NCBI tax ID(s) 152500

Special Collections DSMZ CCUG Literature strains CIP

Links

Burkholderia dolosa AU0645 is an aerobe, mesophilic, Gram-negative prokaryote that was isolated from sputum of cystic fibrosis patient.

Gram-negative motile rod-shaped aerobe mesophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 13005

LMG 18943,CCUG 47727,DSM 16088,CIP 108406

@ref 20215

Last LPSN update 2025-12-16 09:47:13

Domain Pseudomonadati

Phylum Pseudomonadota

Class Betaproteobacteria

Order Burkholderiales

Family Burkholderiaceae

Genus Burkholderia

Species Burkholderia dolosa

Full scientific name Burkholderia dolosa Vermis et al. 2004

BacDive ID	Other strains from **Burkholderia dolosa** (3)	Type strain
1948	B. dolosa HI2112, DSM 26122, ATCC BAA-246, CCUG 45122, ...
1949	B. dolosa PC534, R-3207, DSM 26123, CCUG 45123, LMG ...
1950	B. dolosa PC688, R-3073, DSM 26124, CCUG 45124, LMG ...

Morphology

Cell morphology

@ref	Gram stain	Cell length	Cell shape
30053	negative	2 µm	rod-shaped
118960	negative		rod-shaped
125438	negative

Colony morphology

@ref	Type of hemolysis	Incubation period
6284	gamma	1-2 days

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
6284	CASO AGAR (MERCK 105458) (DSMZ Medium 220)	Medium recipe at MediaDive	Name: CASO AGAR (Merck 105458) (DSMZ Medium 220) Composition: Agar 15.0 g/l Casein peptone 15.0 g/l NaCl 5.0 g/l Soy peptone 5.0 g/l Distilled water
36729	MEDIUM 72- for trypto casein soja agar		Distilled water make up to (1000.000 ml);Trypto casein soy agar (40.000 g)
118960	CIP Medium 339	Medium recipe at CIP
118960	CIP Medium 72	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
6284	positive	growth	28	mesophilic
36729	positive	growth	30	mesophilic
57842	positive	growth	37	mesophilic
118960	positive	growth	30-41
118960	negative	growth	5
118960	negative	growth	10

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
30053	aerobe
57842	aerobe
118960	obligate aerobe
125439	obligate aerobe

Halophily

@ref	Salt	Growth	Tested relation	Concentration
118960	NaCl	positive	growth	0-4 %
118960	NaCl		growth	6 %
118960	NaCl		growth	8 %
118960	NaCl		growth	10 %

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68369	17128 ChEBI	adipate	+	assimilation	from API 20NE
30053	22599 ChEBI	arabinose	+	carbon source
68369	29016 ChEBI	arginine	-	hydrolysis	from API 20NE
68369	17634 ChEBI	D-glucose	+	assimilation	from API 20NE
68369	17634 ChEBI	D-glucose	-	fermentation	from API 20NE
68369	16899 ChEBI	D-mannitol	+	assimilation	from API 20NE
68369	16024 ChEBI	D-mannose	+	assimilation	from API 20NE
68369	27689 ChEBI	decanoate	+	assimilation	from API 20NE
118960	4853 ChEBI	esculin	-	hydrolysis
68369	4853 ChEBI	esculin	-	hydrolysis	from API 20NE
68369	5291 ChEBI	gelatin	-	hydrolysis	from API 20NE
68369	24265 ChEBI	gluconate	+	assimilation	from API 20NE
68369	30849 ChEBI	L-arabinose	+	assimilation	from API 20NE
68369	25115 ChEBI	malate	+	assimilation	from API 20NE
68369	17306 ChEBI	maltose	-	assimilation	from API 20NE
68369	59640 ChEBI	N-acetylglucosamine	+	assimilation	from API 20NE
118960	17632 ChEBI	nitrate	+	reduction
118960	17632 ChEBI	nitrate	-	respiration
68369	17632 ChEBI	nitrate	+	reduction	from API 20NE
118960	16301 ChEBI	nitrite	-	reduction
68369	27897 ChEBI	tryptophan	-	energy source	from API 20NE
68369	16199 ChEBI	urea	-	hydrolysis	from API 20NE

Antibiotic resistance

@ref	Metabolite	Is antibiotic	Is sensitive	Is resistant
118960	0129 (2,4-Diamino-6,7-di-iso-propylpteridine phosphate)

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68369	35581 ChEBI	indole		from API 20NE
118960	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68369	35581 ChEBI	indole	-	from API 20NE

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
118960	alcohol dehydrogenase	-	1.1.1.1
68382	alkaline phosphatase	+	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
118960	amylase	-
68369	arginine dihydrolase	-	3.5.3.6	from API 20NE
68382	beta-galactosidase	-	3.2.1.23	from API zym
118960	beta-galactosidase	+	3.2.1.23
68382	beta-glucosidase	-	3.2.1.21	from API zym
68369	beta-glucosidase	-	3.2.1.21	from API 20NE
68382	beta-glucuronidase	-	3.2.1.31	from API zym
118960	caseinase	-	3.4.21.50
6284	catalase	+	1.11.1.6
118960	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68369	cytochrome oxidase	+	1.9.3.1	from API 20NE
6284	cytochrome-c oxidase	+	1.9.3.1
118960	DNase	-
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
118960	gelatinase	-
68369	gelatinase	-		from API 20NE
118960	lecithinase	-
68382	leucine arylamidase	+	3.4.11.1	from API zym
118960	lipase	-
68382	lipase (C 14)	+		from API zym
118960	lysine decarboxylase	-	4.1.1.18
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
118960	ornithine decarboxylase	-	4.1.1.17
118960	oxidase	+
118960	protease	+
68382	trypsin	-	3.4.21.4	from API zym
118960	tryptophan deaminase	-
118960	tween esterase	+
118960	urease	-	3.5.1.5
68369	urease	-	3.5.1.5	from API 20NE
68382	valine arylamidase	-		from API zym

Fatty acid profile

Metadata FA analysis

@ref

57842

Fatty acid	Percentage	ECL
C16:0	27.2	16
C17:0 CYCLO	24.1	16.888
C19:0 CYCLO ω8c	12.1	18.9
C18:1 ω7c /12t/9t	6.1	17.824
C16:1 ω7c	6	15.819
C14:0 3OH/C16:1 ISO I	5.7	15.485
C16:0 3OH	4.9	17.52
C14:0	4.1	14
C16:0 2OH	3	17.233
C18:1 2OH	1.2	19.088
C16:1 2OH	0.9	17.047
C14:0 2OH	0.8	15.205
C16:1 ω5c	0.6	15.908
Unidentified	0.6	18.139
C13:1 at 12-13	0.5	12.931
C15:0	0.4	15
unknown 18.445	0.4	18.445
C18:0	0.4	18
Unidentified	0.3	16.091
Unidentified	0.3	17.748
C12:0 ALDE ?	0.2	10.915
C17:0	0.2	17

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
118960	-	+	+	+	+	+	-	-	-	-	+	+	-	-	-	-	-	+	-	-

API 20NE

@ref	Reduction of nitratesNO3	TRP	GLU_ Ferm	ADH (Arg)	URE	ESC	GEL	PNPG	GLU_ Assim	ARA	MNE	MAN	NAG	MAL	GNT	CAP	ADI	MLT	CIT	PAC	OX
6284	+	-	-	-	-	-	-	+	+	+	+	+	+	-	+	+	+	+	+	+	+
6284	+	-	-	-	-	-	-	+	+	+	+	+	+	-	+	+	+	+	+	+	not determinedn.d.

API biotype100

@ref	ControlQ	D-glucose as carbon sourceGLU	D-fructose as carbon sourceFRU	D-galactose as carbon sourceGAL	D-trehalose as carbon sourceTRE	D-mannose as carbon sourceMNE	L-sorbose as carbon sourceSBE	D-melibiose as carbon sourceMEL	sucrose as carbon sourceSAC	D-raffinose as carbon sourceRAF	maltotriose as carbon sourceMTE	maltose as carbon sourceMAL	lactose as carbon sourceLAC	lactulose as carbon sourceLTE	1-O-methyl-beta-galactopyranoside as carbon sourceMbGa	1-O-methyl-alpha-galactopyranoside as carbon sourceMaGa	D-cellobiose as carbon sourceCEL	gentiobiose as carbon sourceGEN	1-O-methyl-beta-D-glucopyranoside as carbon sourceMbGu	esculin as carbon sourceESC	D-ribose as carbon sourceRIB	L-arabinose as carbon sourceARA	D-xylose as carbon sourceXYL	palatinose as carbon sourcePLE	L-rhamnose as carbon sourceRHA	L-fucose as carbon sourceFUC	D-melezitose as carbon sourceMLZ	D-arabitol as carbon sourceDARL	L-arabitol as carbon sourceLARL	xylitol as carbon sourceXLT	dulcitol as carbon sourceDUL	D-tagatose as carbon sourceTAG	glycerol as carbon sourceGLY	myo-inositol as carbon sourceINO	D-mannitol as carbon sourceMAN	maltitol as carbon sourceMTL	D-turanose as carbon sourceTUR	D-sorbitol as carbon sourceSOR	adonitol as carbon sourceADO	hydroxyquinoline-beta-glucuronide as carbon sourceHBG	D-lyxose as carbon sourceLYX	i-erythritol as carbon sourceERY	1-O-methyl-alpha-D-glucoside as carbon sourceMDG	3-O-methyl-D-glucose as carbon source3MDG	D-saccharate as carbon sourceSAT	mucate as carbon sourceMUC	L-tartrate as carbon sourceLTAT	D-tartrate as carbon sourceDTAT	meso-tartrate as carbon sourceMTAT	D-malate as carbon sourceDMLT	L-malate as carbon sourceLMLT	cis-aconitate as carbon sourceCATE	trans-aconitate as carbon sourceTATE	tricarballylate as carbon sourceTTE	citrate as carbon sourceCIT	D-glucuronate as carbon sourceGRT	D-galacturonate as carbon sourceGAT	2-ketogluconate as carbon source2KG	5-ketogluconate as carbon source5KG	tryptophan as carbon sourceTRY	N-acetyl-D-glucosamine as carbon sourceNAG	D-gluconate as carbon sourceGNT	phenylacetate as carbon sourcePAC	protocatechuate as carbon sourcePAT	4-hydroxybenzoate as carbon sourcepOBE	quinate as carbon sourceQAT	gentisate as carbon sourceGTE	3-hydroxybenzoate as carbon sourcemOBE	benzoate as carbon sourceBAT	3-phenylpropionate as carbon sourcePPAT	m-coumarate as carbon sourceCMT	trigonelline as carbon sourceTGE	betaine as carbon sourceBET	putrescine as carbon sourcePCE	4-aminobutyrate as carbon sourceABT	histamine as carbon sourceHIN	DL-lactate as carbon sourceLAT	caprate as carbon sourceCAP	caprylate as carbon sourceCYT	L-histidine as carbon sourceHIS	succinate as carbon sourceSUC	fumarate as carbon sourceFUM	glutarate as carbon sourceGRE	DL-glycerate as carbon sourceGYT	5-aminovalerate as carbon sourceAVT	ethanolamine as carbon sourceETN	tryptamine as carbon sourceTTN	D-glucosamine as carbon sourceGLN	itaconate as carbon sourceITA	3-hydroxybutyrate as carbon source3OBU	L-aspartate as carbon sourceAPT	L-glutamate as carbon sourceGTT	L-proline as carbon sourcePRO	D-alanine as carbon sourceDALA	L-alanine as carbon sourceLALA	L-serine as carbon sourceSER	malonate as carbon sourceMNT	propionate as carbon sourcePROP	L-tyrosine as carbon sourceTYR	2-ketoglutarate as carbon source2KT
118960	not determinedn.d.	+	+	+	+	+	-	-	-	-	-	-	-	-	+	-	-	-	-	-	+	+	+	-	-	+	-	+	+	-	+	+	+	+	+	-	-	+	+	-	+	-	-	-	+	+	-	-	+	+	+	+	+	-	+	+	+	+	-	-	+	+	+	+	+	+	-	-	-	-	-	-	+	+	+	-	-	+	+	-	+	+	+	-	-	+	-	+	-	+	+	+	+	+	+	+	+	+	+	+

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Infection	#Disease	#Cystic fibrosis
#Infection	#Patient	-
#Host Body Product	#Fluids	#Sputum

Isolation

@ref	Sample type	Country	Country ISO 3 Code	Continent
6284	sputum of cystic fibrosis patient	USA	USA	North America
57842	Human sputum,cystic fibrosis	USA	USA	North America
118960	Human, Sputum, cystic fibrosis	United States of America	USA	North America

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
6284	2	Risk group (German classification) According to TRBA 466
118960	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	BV-BRC accession	NCBI tax ID	Score
66792	Burkholderia dolosa strain FDAARGOS_1463	complete	152500.66	152500	99.19
66792	Burkholderia dolosa strain FDAARGOS_1463	complete	152500.52	152500	99.19
66792	Burkholderia dolosa strain FDAARGOS_1463	complete	152500.41	152500	99.19
124043	ASM1993078v1 assembly for Burkholderia dolosa FDAARGOS_1463	complete	152500.30	152500	99.02
66792	ASM90249913v1 assembly for Burkholderia dolosa LMG 18943	contig	152500.12	152500	46.37

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Burkholderia dolosa strain LMG 18943 16S ribosomal RNA gene, partial sequence	HQ849079	1124		152500
20218	Burkholderia dolosa strain LMG 18943 16S ribosomal RNA gene, partial sequence	JX986970	1485		152500

GC content

30053

GC-content (mol%)67.3

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Burkholderia dolosa strain FDAARGOS_1463
PATRIC: 152500.30

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	86.70	no
125439	motility	BacteriaNetⓘ	yes	69.10	no
125439	gram_stain	BacteriaNetⓘ	negative	78.30	no
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	99.50	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Burkholderia dolosa strain FDAARGOS_1463 strain Not applicable
PATRIC: 152500.30

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	97.50	yes
125438	anaerobic	anaerobicⓘ	no	97.53	yes
125438	spore-forming	spore-formingⓘ	no	87.48	no
125438	aerobic	aerobicⓘ	yes	89.57	no
125438	thermophilic	thermophileⓘ	no	96.50	no
125438	flagellated	motile2+ⓘ	yes	79.53	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Genomic insights into an extensively drug-resistant and hypervirulent Burkholderia dolosa N149 isolate of a novel sequence type (ST2237) from a Vietnamese patient hospitalised for stroke.	Nguyen QH, Nguyen CL, Nguyen TS, Do BN, Tran TTT, Le TTH, Bui TT, Le HS, Quyen DV, Hayer J, Banuls AL, Bui TS.	J Glob Antimicrob Resist	10.1016/j.jgar.2024.02.009	2024
	De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen.	Poret AJ, Schaefers M, Merakou C, Mansour KE, Ahern CD, Lagoudas GK, Haynes A, Cross AR, Goldberg JB, Kishony R, Uluer AZ, McAdam AJ, Blainey PC, Vargas SO, Lieberman TD, Priebe GP.	Nat Commun	10.1038/s41467-025-61168-4	2025
	Whole-Genome Deep Sequencing of the Healthy Adult Nasal Microbiome.	Cannon M, Ferrer G, Tesch M, Schipma M.	Microorganisms	10.3390/microorganisms12071407	2024
Proteome	What Are We Missing by Using Hydrophilic Enrichment? Improving Bacterial Glycoproteome Coverage Using Total Proteome and FAIMS Analyses.	Ahmad Izaham AR, Ang CS, Nie S, Bird LE, Williamson NA, Scott NE.	J Proteome Res	10.1021/acs.jproteome.0c00565	2021
	Recipient Cell Factors Influence Interbacterial Competition Mediated by Two Distinct Burkholderia dolosa Contact-Dependent Growth Inhibition Systems.	Elery ZK, Oates AE, Myers-Morales T, Garcia EC.	J Bacteriol	10.1128/jb.00541-21	2022
	A flagella-dependent Burkholderia jumbo phage controls rice seedling rot and steers Burkholderia glumae toward reduced virulence in rice seedlings.	Supina BSI, McCutcheon JG, Peskett SR, Stothard P, Dennis JJ.	mBio	10.1128/mbio.02814-24	2025
	Genomic diversity of non-typhoidal Salmonella found in patients suffering from gastroenteritis in Norfolk, UK.	Rudder SJ, Djeghout B, Elumogo N, Janecko N, Langridge GC.	Microb Genom	10.1099/mgen.0.001468	2025
	Survival after lung transplantation of cystic fibrosis patients infected with Burkholderia dolosa (genomovar VI).	Wang R, Welsh SK, Budev M, Goldberg H, Noone PG, Gray A, Zaas D, Boyer D.	Clin Transplant	10.1111/ctr.13236	2018
	Role of bacteriophage therapy for resistant infections in transplant recipients.	Nicholls P, Aslam S.	Curr Opin Organ Transplant	10.1097/mot.0000000000001029	2022
	A Phase IIa, Single-Blind, Placebo-Controlled, Parallel-Group Study to Assess Safety, Tolerability, and Pharmacokinetics/Pharmacodynamics of Brensocatib in Adults with Cystic Fibrosis.	Konstan MW, Tolle JJ, DiMango E, Flume PA, Usansky H, Teper A, Ramirez CN, Flarakos J, Basso J, Li S, Vergara M.	Clin Pharmacokinet	10.1007/s40262-025-01550-z	2025
	Relaxed specificity of BcpB transporters mediates interactions between Burkholderia cepacia complex contact-dependent growth inhibition systems.	Elery ZK, Myers-Morales T, Phillips ED, Garcia EC.	mSphere	10.1128/msphere.00303-23	2023
	Elexacaftor-tezacaftor-ivacaftor in patients with cystic fibrosis ineligible for clinical trials: a 24-week observational study.	Fila L, Grandcourtova A, Bilkova A, Drevinek P.	Front Pharmacol	10.3389/fphar.2023.1178009	2023
	Are Burkholderia Emerging Pathogens in patients with underlying morbidity: A case series.	Kumari S, Banu M, Ramanatha K, Barani R, Sridharan KS.	Heliyon	10.1016/j.heliyon.2024.e33283	2024
Genetics	Genomic editing in Burkholderia multivorans by CRISPR/Cas9.	Ferreira MR, Queiroga V, Moreira LM.	Appl Environ Microbiol	10.1128/aem.02250-23	2024
Genetics	Genomic evidence of Escherichia coli gut population diversity translocation in leukemia patients.	Marin J, Walewski V, Braun T, Dziri S, Magnan M, Denamur E, Carbonnelle E, Bridier-Nahmias A.	mSphere	10.1128/msphere.00530-24	2024
	Toward the Characterization of the Human Core Ocular Surface Microbiome.	Morandi SC, Uldry AC, Eldridge N, Kreuzer M, Herzog EL, Zinkernagel M, Zysset-Burri DC.	Invest Ophthalmol Vis Sci	10.1167/iovs.66.9.40	2025
	Phage Therapy Administration Route, Regimen, and Need for Supplementary Antibiotics in Patients with Chronic Suppurative Lung Disease.	Williams J, Severin J, Temperton B, Mitchelmore PJ.	Phage (New Rochelle)	10.1089/phage.2022.0036	2023
Genetics	Rapid sequencing of MRSA direct from clinical plates in a routine microbiology laboratory.	Blane B, Raven KE, Leek D, Brown N, Parkhill J, Peacock SJ.	J Antimicrob Chemother	10.1093/jac/dkz170	2019
	Phage Milagro: a platform for engineering a broad host range virulent phage for Burkholderia.	Yao G, Le T, Korn AM, Peterson HN, Liu M, Gonzalez CF, Gill JJ.	J Virol	10.1128/jvi.00850-23	2023
Phylogeny	Accurate identification of members of the Burkholderia cepacia complex in cystic fibrosis sputum.	Martinucci M, Roscetto E, Iula VD, Votsi A, Catania MR, De Gregorio E.	Lett Appl Microbiol	10.1111/lam.12537	2016
Enzymology	Burkholderia dolosa phenotypic variation during the decline in lung function of a cystic fibrosis patient during 5.5 years of chronic colonization.	Moreira AS, Coutinho CP, Azevedo P, Lito L, Melo-Cristino J, Sa-Correia I.	J Med Microbiol	10.1099/jmm.0.069849-0	2014
	Detecting Genetic Variation of Colonizing Streptococcus agalactiae Genomes in Humans: A Precision Protocol.	Zhou Y, Zhao XC, Wang LQ, Chen CW, Hsu MH, Liao WT, Deng X, Yan Q, Zhao GP, Chen CL, Zhang L, Chiu CH.	Front Bioinform	10.3389/fbinf.2022.813599	2022
Metabolism	Chemistry and biology of the potent endotoxin from a Burkholderia dolosa clinical isolate from a cystic fibrosis patient.	Lorenzo FD, Sturiale L, Palmigiano A, Lembo-Fazio L, Paciello I, Coutinho CP, Sa-Correia I, Bernardini M, Lanzetta R, Garozzo D, Silipo A, Molinaro A.	Chembiochem	10.1002/cbic.201300062	2013
	Draft Genome Sequence of Burkholderia dolosa PC543 Isolated from Cystic Fibrosis Airways.	Workentine ML, Surette MG, Bernier SP.	Genome Announc	10.1128/genomea.00043-14	2014
	Inhaled amiloride and tobramycin solutions fail to eradicate Burkholderia dolosa in patients with cystic fibrosis.	Uluer AZ, Waltz DA, Kalish LA, Adams S, Gerard C, Ericson DA.	J Cyst Fibros	10.1016/j.jcf.2012.06.006	2013
	Burkholderia cenocepacia-mediated inhibition of Staphylococcus aureus growth and biofilm formation.	Brandt TJ, Skaggs H, Hundley T, Yoder-Himes DR.	J Bacteriol	10.1128/jb.00116-23	2025
	Septic Transfusion Reactions Involving Burkholderia cepacia Complex: A Review.	Salamanca-Pachon M, Guayacan-Fuquene NI, Garcia-Otalora MA.	Microorganisms	10.3390/microorganisms12010040	2023
Genetics	An integrated strain-level analytic pipeline utilizing longitudinal metagenomic data.	Zhou B, Wang C, Putzel G, Hu J, Liu M, Wu F, Chen Y, Pironti A, Li H.	Microbiol Spectr	10.1128/spectrum.01431-24	2024
Enzymology	The Bacterial Genomic Context of Highly Trimethoprim-Resistant DfrB Dihydrofolate Reductases Highlights an Emerging Threat to Public Health.	Lemay-St-Denis C, Diwan SS, Pelletier JN.	Antibiotics (Basel)	10.3390/antibiotics10040433	2021
	Screening of Hydrophilic Polymers Reveals Broad Activity in Protecting Phages during Cryopreservation.	Marton HL, Bhatt A, Sagona AP, Kilbride P, Gibson MI.	Biomacromolecules	10.1021/acs.biomac.3c01042	2024
Cultivation	Evaluation of Three Culture Media for Isolation of Burkholderia cepacia Complex from Respiratory Samples of Patients with Cystic Fibrosis.	Marrs ECL, Perry A, Perry JD.	Microorganisms	10.3390/microorganisms9122604	2021
	Chance and necessity in the evolution of a bacterial pathogen.	Lenski RE.	Nat Genet	10.1038/ng.1011	2011
Pathogenicity	PHERI-Phage Host ExploRation Pipeline.	Balaz A, Kajsik M, Budis J, Szemes T, Turna J.	Microorganisms	10.3390/microorganisms11061398	2023
Pathogenicity	Activity of Tobramycin against Cystic Fibrosis Isolates of Burkholderia cepacia Complex Grown as Biofilms.	Kennedy S, Beaudoin T, Yau YC, Caraher E, Zlosnik JE, Speert DP, LiPuma JJ, Tullis E, Waters V.	Antimicrob Agents Chemother	10.1128/aac.02068-15	2016
	Within-host evolution of bacterial pathogens during persistent infection of humans.	Grote A, Earl AM.	Curr Opin Microbiol	10.1016/j.mib.2022.102197	2022
Pathogenicity	In Vitro Activity of a Novel Glycopolymer against Biofilms of Burkholderia cepacia Complex Cystic Fibrosis Clinical Isolates.	Narayanaswamy VP, Duncan AP, LiPuma JJ, Wiesmann WP, Baker SM, Townsend SM.	Antimicrob Agents Chemother	10.1128/aac.00498-19	2019
	Three Distinct Contact-Dependent Growth Inhibition Systems Mediate Interbacterial Competition by the Cystic Fibrosis Pathogen Burkholderia dolosa.	Perault AI, Cotter PA.	J Bacteriol	10.1128/jb.00428-18	2018
Phylogeny	SNPPar: identifying convergent evolution and other homoplasies from microbial whole-genome alignments.	Edwards DJ, Duchene S, Pope B, Holt KE.	Microb Genom	10.1099/mgen.0.000694	2021
	Early clinical experience of bacteriophage therapy in 3 lung transplant recipients.	Aslam S, Courtwright AM, Koval C, Lehman SM, Morales S, Furr CL, Rosas F, Brownstein MJ, Fackler JR, Sisson BM, Biswas B, Henry M, Luu T, Bivens BN, Hamilton T, Duplessis C, Logan C, Law N, Yung G, Turowski J, Anesi J, Strathdee SA, Schooley RT.	Am J Transplant	10.1111/ajt.15503	2019
	N-acyl-homoserine lactone produced by Rahnella inusitata isolated from the gut of Galleria mellonella influences Salmonella phenotypes.	de Freitas LL, Carneiro DG, Oliveira GS, Vanetti MCD.	Braz J Microbiol	10.1007/s42770-022-00681-w	2022
Enzymology	Functional characterization and biological significance of Yersinia pestis lipopolysaccharide biosynthesis genes.	Dentovskaya SV, Anisimov AP, Kondakova AN, Lindner B, Bystrova OV, Svetoch TE, Shaikhutdinova RZ, Ivanov SA, Bakhteeva IV, Titareva GM, Knirel AY.	Biochemistry (Mosc)	10.1134/s0006297911070121	2011
	Antibiotherapy in Children with Cystic Fibrosis-An Extensive Review.	Ciuca IM, Dediu M, Popin D, Pop LL, Tamas LA, Pilut CN, Almajan Guta B, Popa ZL.	Children (Basel)	10.3390/children9081258	2022
Pathogenicity	A single-cell imaging screen reveals multiple effects of secreted small molecules on bacteria.	Salje J.	Microbiologyopen	10.1002/mbo3.176	2014
	Clinical characteristics, diagnosis, outcomes and lung microbiome analysis of invasive pulmonary aspergillosis in the community-acquired pneumonia patients.	Ao Z, Xu H, Li M, Liu H, Deng M, Liu Y.	BMJ Open Respir Res	10.1136/bmjresp-2022-001358	2023
Metabolism	Cloning and overexpression of the xylose isomerase gene from Burkholderia sacchari and production of polyhydroxybutyrate from xylose.	Lopes MS, Gomez JG, Silva LF.	Can J Microbiol	10.1139/w09-055	2009
	Sequence heterogeneity of the PenA carbapenemase in clinical isolates of Burkholderia multivorans.	Becka SA, Zeiser ET, Marshall SH, Gatta JA, Nguyen K, Singh I, Greco C, Sutton GG, Fouts DE, LiPuma JJ, Papp-Wallace KM.	Diagn Microbiol Infect Dis	10.1016/j.diagmicrobio.2018.06.005	2018
Genetics	Geography, niches, and transportation influence bovine respiratory microbiome and health.	Chai J, Liu X, Usdrowski H, Deng F, Li Y, Zhao J.	Front Cell Infect Microbiol	10.3389/fcimb.2022.961644	2022
Pathogenicity	Contact-dependent growth inhibition (CDI) systems deploy a large family of polymorphic ionophoric toxins for inter-bacterial competition.	Halvorsen TM, Schroeder KA, Jones AM, Hammarlof D, Low DA, Koskiniemi S, Hayes CS.	PLoS Genet	10.1371/journal.pgen.1011494	2024
Pathogenicity	The Mla Pathway Plays an Essential Role in the Intrinsic Resistance of Burkholderia cepacia Complex Species to Antimicrobials and Host Innate Components.	Bernier SP, Son S, Surette MG.	J Bacteriol	10.1128/jb.00156-18	2018
Enzymology	Purification and visualization of lipopolysaccharide from Gram-negative bacteria by hot aqueous-phenol extraction.	Davis MR, Goldberg JB.	J Vis Exp	10.3791/3916	2012
	Immune Recognition of the Epidemic Cystic Fibrosis Pathogen Burkholderia dolosa.	Roux D, Weatherholt M, Clark B, Gadjeva M, Renaud D, Scott D, Skurnik D, Priebe GP, Pier G, Gerard C, Yoder-Himes DR.	Infect Immun	10.1128/iai.00765-16	2017
	Invasion and biofilm formation of Burkholderia dolosa is comparable with Burkholderia cenocepacia and Burkholderia multivorans.	Caraher E, Duff C, Mullen T, Mc Keon S, Murphy P, Callaghan M, McClean S.	J Cyst Fibros	10.1016/j.jcf.2006.05.007	2007
Pathogenicity	Lower Airway Dysbiosis Augments Lung Inflammatory Injury in Mild-to-Moderate Chronic Obstructive Pulmonary Disease.	Sulaiman I, Wu BG, Chung M, Isaacs B, Tsay JJ, Holub M, Barnett CR, Kwok B, Kugler MC, Natalini JG, Singh S, Li Y, Schluger R, Carpenito J, Collazo D, Perez L, Kyeremateng Y, Chang M, Campbell CD, Hansbro PM, Oppenheimer BW, Berger KI, Goldring RM, Koralov SB, Weiden MD, Xiao R, D'Armiento J, Clemente JC, Ghedin E, Segal LN.	Am J Respir Crit Care Med	10.1164/rccm.202210-1865oc	2023
Pathogenicity	Pseudomonas aeruginosa-Derived Rhamnolipids and Other Detergents Modulate Colony Morphotype and Motility in the Burkholderia cepacia Complex.	Bernier SP, Hum C, Li X, O'Toole GA, Magarvey NA, Surette MG.	J Bacteriol	10.1128/jb.00171-17	2017
	Identification of Key Factors for Anoxic Survival of B. cenocepacia H111.	Paszti S, Vitale A, Liu Y, Braunwalder R, Kalawong R, Biner O, Pessi G, Eberl L.	Int J Mol Sci	10.3390/ijms23094560	2022
Metabolism	Burkholderia cepacia Complex Species Differ in the Frequency of Variation of the Lipopolysaccharide O-Antigen Expression During Cystic Fibrosis Chronic Respiratory Infection.	Hassan AA, Coutinho CP, Sa-Correia I.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00273	2019
	Impact of Burkholderia dolosa on lung function and survival in cystic fibrosis.	Kalish LA, Waltz DA, Dovey M, Potter-Bynoe G, McAdam AJ, Lipuma JJ, Gerard C, Goldmann D.	Am J Respir Crit Care Med	10.1164/rccm.200503-344oc	2006
	Evidence of transmission of Burkholderia cepacia, Burkholderia multivorans and Burkholderia dolosa among persons with cystic fibrosis.	Biddick R, Spilker T, Martin A, LiPuma JJ.	FEMS Microbiol Lett	10.1016/s0378-1097(03)00724-9	2003
Pathogenicity	The effect of recombinant human lactoferrin on growth and the antibiotic susceptibility of the cystic fibrosis pathogen Burkholderia cepacia complex when cultured planktonically or as biofilms.	Caraher EM, Gumulapurapu K, Taggart CC, Murphy P, McClean S, Callaghan M.	J Antimicrob Chemother	10.1093/jac/dkm222	2007
	Eradication therapy for Burkholderia cepacia complex in people with cystic fibrosis.	Regan KH, Bhatt J.	Cochrane Database Syst Rev	10.1002/14651858.cd009876.pub4	2019
	Lung transplant referral practice patterns: a survey of cystic fibrosis physicians and general pulmonologists.	Bartley BL, Schwartz CE, Stark RB, Georgiopoulos AM, Friedman D, Richards CJ, Dorkin HL, Kinane TB, Neuringer IP, Yonker LM.	BMC Pulm Med	10.1186/s12890-020-1067-4	2020
	Bacterial evolution during human infection: Adapt and live or adapt and die.	Culyba MJ, Van Tyne D.	PLoS Pathog	10.1371/journal.ppat.1009872	2021
	Interbacterial signaling via Burkholderia contact-dependent growth inhibition system proteins.	Garcia EC, Perault AI, Marlatt SA, Cotter PA.	Proc Natl Acad Sci U S A	10.1073/pnas.1606323113	2016
Pathogenicity	The within-host evolution of antimicrobial resistance in Mycobacterium tuberculosis.	Castro RAD, Borrell S, Gagneux S.	FEMS Microbiol Rev	10.1093/femsre/fuaa071	2021
	Effect of beta-Lactamase inhibitors on in vitro activity of beta-Lactam antibiotics against Burkholderia cepacia complex species.	Everaert A, Coenye T.	Antimicrob Resist Infect Control	10.1186/s13756-016-0142-3	2016
	Generation of Genetic Tools for Gauging Multiple-Gene Expression at the Single-Cell Level.	Mellini M, Lucidi M, Imperi F, Visca P, Leoni L, Rampioni G.	Appl Environ Microbiol	10.1128/aem.02956-20	2021
	A putative lateral flagella of the cystic fibrosis pathogen Burkholderia dolosa regulates swimming motility and host cytokine production.	Roux D, Schaefers M, Clark BS, Weatherholt M, Renaud D, Scott D, LiPuma JJ, Priebe G, Gerard C, Yoder-Himes DR.	PLoS One	10.1371/journal.pone.0189810	2018
	Microbiota in organ transplantation: An immunological and therapeutic conundrum?	Dery KJ, Kadono K, Hirao H, Gorski A, Kupiec-Weglinski JW.	Cell Immunol	10.1016/j.cellimm.2020.104080	2020
Enzymology	Impact of clonally-related Burkholderia contaminans strains in two patients attending an Italian cystic fibrosis centre: a case report.	Savi D, Quattrucci S, Trancassini M, Dalmastri C, De Biase RV, Maggisano M, Palange P, Bevivino A.	BMC Pulm Med	10.1186/s12890-019-0923-6	2019
	Infection leaves a genetic and functional mark on the gut population of a commensal bacterium.	Tawk C, Lim B, Bencivenga-Barry NA, Lees HJ, Ramos RJF, Cross J, Goodman AL.	Cell Host Microbe	10.1016/j.chom.2023.04.005	2023
Enzymology	Matrix-assisted laser desorption/ionization time-of-flight MS for the accurate identification of Burkholderia cepacia complex and Burkholderia gladioli in the clinical microbiology laboratory.	Wong KSK, Dhaliwal S, Bilawka J, Srigley JA, Champagne S, Romney MG, Tilley P, Sadarangani M, Zlosnik JEA, Chilvers MA.	J Med Microbiol	10.1099/jmm.0.001223	2020
	Comparison of Mast Burkholderia Cepacia, Ashdown + Gentamicin, and Burkholderia Pseudomallei Selective Agar for the Selective Growth of Burkholderia Spp.	Edler C, Derschum H, Kohler M, Neubauer H, Frickmann H, Hagen RM.	Eur J Microbiol Immunol (Bp)	10.1556/1886.2016.00037	2017
	Genetic variation of a bacterial pathogen within individuals with cystic fibrosis provides a record of selective pressures.	Lieberman TD, Flett KB, Yelin I, Martin TR, McAdam AJ, Priebe GP, Kishony R.	Nat Genet	10.1038/ng.2848	2014
	Practical Guidance for Clinical Microbiology Laboratories: Updated guidance for processing respiratory tract samples from people with cystic fibrosis.	Saiman L, Waters V, LiPuma JJ, Hoffman LR, Alby K, Zhang SX, Yau YC, Downey DG, Sermet-Gaudelus I, Bouchara J-P, Kidd TJ, Bell SC, Brown AW.	Clin Microbiol Rev	10.1128/cmr.00215-21	2024
	Genomic diversity of Helicobacter pylori populations from different regions of the human stomach.	Wilkinson DJ, Dickins B, Robinson K, Winter JA.	Gut Microbes	10.1080/19490976.2022.2152306	2022
	ConStrains identifies microbial strains in metagenomic datasets.	Luo C, Knight R, Siljander H, Knip M, Xavier RJ, Gevers D.	Nat Biotechnol	10.1038/nbt.3319	2015
Pathogenicity	Targeting pan-resistant bacteria with antibodies to a broadly conserved surface polysaccharide expressed during infection.	Skurnik D, Davis MR, Benedetti D, Moravec KL, Cywes-Bentley C, Roux D, Traficante DC, Walsh RL, Maira-Litran T, Cassidy SK, Hermos CR, Martin TR, Thakkallapalli EL, Vargas SO, McAdam AJ, Lieberman TD, Kishony R, Lipuma JJ, Pier GB, Goldberg JB, Priebe GP.	J Infect Dis	10.1093/infdis/jis254	2012
	Parallel bacterial evolution within multiple patients identifies candidate pathogenicity genes.	Lieberman TD, Michel JB, Aingaran M, Potter-Bynoe G, Roux D, Davis MR, Skurnik D, Leiby N, LiPuma JJ, Goldberg JB, McAdam AJ, Priebe GP, Kishony R.	Nat Genet	10.1038/ng.997	2011
Genetics	Whole-genome sequencing to investigate a non-clonal melioidosis cluster on a remote Australian island.	Sarovich DS, Chapple SNJ, Price EP, Mayo M, Holden MTG, Peacock SJ, Currie BJ.	Microb Genom	10.1099/mgen.0.000117	2017
	Antibiotic treatment for Burkholderia cepacia complex in people with cystic fibrosis experiencing a pulmonary exacerbation.	Lord R, Jones AM, Horsley A.	Cochrane Database Syst Rev	10.1002/14651858.cd009529.pub4	2020
Pathogenicity	Antibacterial activity of a lectin-like Burkholderia cenocepacia protein.	Ghequire MG, De Canck E, Wattiau P, Van Winge I, Loris R, Coenye T, De Mot R.	Microbiologyopen	10.1002/mbo3.95	2013
	Host and pathogen response to bacteriophage engineered against Mycobacterium abscessus lung infection.	Nick JA, Dedrick RM, Gray AL, Vladar EK, Smith BE, Freeman KG, Malcolm KC, Epperson LE, Hasan NA, Hendrix J, Callahan K, Walton K, Vestal B, Wheeler E, Rysavy NM, Poch K, Caceres S, Lovell VK, Hisert KB, de Moura VC, Chatterjee D, De P, Weakly N, Martiniano SL, Lynch DA, Daley CL, Strong M, Jia F, Hatfull GF, Davidson RM.	Cell	10.1016/j.cell.2022.04.024	2022
Genetics	A Combination of Metagenomic and Cultivation Approaches Reveals Hypermutator Phenotypes within Vibrio cholerae-Infected Patients.	Levade I, Khan AI, Chowdhury F, Calderwood SB, Ryan ET, Harris JB, LaRocque RC, Bhuiyan TR, Qadri F, Weil AA, Shapiro BJ.	mSystems	10.1128/msystems.00889-21	2021
	Immune response to recombinant Burkholderia pseudomallei FliC.	Koosakulnirand S, Phokrai P, Jenjaroen K, Roberts RA, Utaisincharoen P, Dunachie SJ, Brett PJ, Burtnick MN, Chantratita N.	PLoS One	10.1371/journal.pone.0198906	2018
Phylogeny	Kill and cure: genomic phylogeny and bioactivity of Burkholderia gladioli bacteria capable of pathogenic and beneficial lifestyles.	Jones C, Webster G, Mullins AJ, Jenner M, Bull MJ, Dashti Y, Spilker T, Parkhill J, Connor TR, LiPuma JJ, Challis GL, Mahenthiralingam E.	Microb Genom	10.1099/mgen.0.000515	2021
Metabolism	O-Antigen-Dependent Colicin Insensitivity of Uropathogenic Escherichia coli.	Sharp C, Boinett C, Cain A, Housden NG, Kumar S, Turner K, Parkhill J, Kleanthous C.	J Bacteriol	10.1128/jb.00545-18	2019
Genetics	A Phylogeny-Informed Proteomics Approach for Species Identification within the Burkholderia cepacia Complex.	Wang H, Cisse OH, Bolig T, Drake SK, Chen Y, Strich JR, Youn JH, Okoro U, Rosenberg AZ, Sun J, LiPuma JJ, Suffredini AF, Dekker JP.	J Clin Microbiol	10.1128/jcm.01741-20	2020
	Identification of Burkholderia pseudomallei Genes Induced During Infection of Macrophages by Differential Fluorescence Induction.	Jitprasutwit S, Jitprasutwit N, Hemsley CM, Onlamoon N, Withatanung P, Muangsombut V, Vattanaviboon P, Stevens JM, Ong C, Stevens MP, Titball RW, Korbsrisate S.	Front Microbiol	10.3389/fmicb.2020.00072	2020
Genetics	Genomic characterization of JG068, a novel virulent podovirus active against Burkholderia cenocepacia.	Lynch KH, Abdu AH, Schobert M, Dennis JJ, Dennis JJ.	BMC Genomics	10.1186/1471-2164-14-574	2013
	An Oxygen-Sensing Two-Component System in the Burkholderia cepacia Complex Regulates Biofilm, Intracellular Invasion, and Pathogenicity.	Schaefers MM, Liao TL, Boisvert NM, Roux D, Yoder-Himes D, Priebe GP.	PLoS Pathog	10.1371/journal.ppat.1006116	2017
Genetics	Complete genome sequencing of Pandoraea pnomenusa RB38 and Molecular Characterization of Its N-acyl homoserine lactone synthase gene ppnI.	Lim YL, Ee R, How KY, Lee SK, Yong D, Tee KK, Yin WF, Chan KG.	PeerJ	10.7717/peerj.1225	2015
Pathogenicity	Phenotypic and Genotypic Adaptations in Pseudomonas aeruginosa Biofilms following Long-Term Exposure to an Alginate Oligomer Therapy.	Oakley JL, Weiser R, Powell LC, Forton J, Mahenthiralingam E, Rye PD, Hill KE, Thomas DW, Pritchard MF.	mSphere	10.1128/msphere.01216-20	2021
Phylogeny	Matrix-assisted laser desorption ionization-time of flight mass spectrometry for identification of nonfermenting gram-negative bacilli isolated from cystic fibrosis patients.	Degand N, Carbonnelle E, Dauphin B, Beretti JL, Le Bourgeois M, Sermet-Gaudelus I, Segonds C, Berche P, Nassif X, Ferroni A.	J Clin Microbiol	10.1128/jcm.00569-08	2008
Pathogenicity	Long-Term Intrahost Evolution of Methicillin Resistant Staphylococcus aureus Among Cystic Fibrosis Patients With Respiratory Carriage.	Azarian T, Ridgway JP, Yin Z, David MZ.	Front Genet	10.3389/fgene.2019.00546	2019
Genetics	Genome Analysis of a Novel Broad Host Range Proteobacteria Phage Isolated from a Bioreactor Treating Industrial Wastewater.	de Leeuw M, Baron M, Brenner A, Kushmaro A.	Genes (Basel)	10.3390/genes8010040	2017
	Burkholderia cepacia Complex Contact-Dependent Growth Inhibition Systems Mediate Interbacterial Competition.	Myers-Morales T, Oates AE, Byrd MS, Garcia EC.	J Bacteriol	10.1128/jb.00012-19	2019
Pathogenicity	Biocide susceptibility of the Burkholderia cepacia complex.	Rose H, Baldwin A, Dowson CG, Mahenthiralingam E.	J Antimicrob Chemother	10.1093/jac/dkn540	2009
	Gene expression profiling of Burkholderia cenocepacia at the time of cepacia syndrome: loss of motility as a marker of poor prognosis?	Kalferstova L, Kolar M, Fila L, Vavrova J, Drevinek P.	J Clin Microbiol	10.1128/jcm.03605-14	2015
Genetics	Whole-Genome Sequencing of Three Clonal Clinical Isolates of B. cenocepacia from a Patient with Cystic Fibrosis.	Miller RR, Hird TJ, Tang P, Zlosnik JE.	PLoS One	10.1371/journal.pone.0143472	2015
Genetics	Plasmid Dynamics in KPC-Positive Klebsiella pneumoniae during Long-Term Patient Colonization.	Conlan S, Park M, Deming C, Thomas PJ, Young AC, Coleman H, Sison C, NISC Comparative Sequencing Program, Weingarten RA, Lau AF, Dekker JP, Palmore TN, Frank KM, Segre JA.	mBio	10.1128/mbio.00742-16	2016
Genetics	Evolution of Acinetobacter baumannii In Vivo: International Clone II, More Resistance to Ceftazidime, Mutation in ptk.	Hua X, Zhou Z, Yang Q, Shi Q, Xu Q, Wang J, Shi K, Zhao F, Sun L, Ruan Z, Jiang Y, Yu Y.	Front Microbiol	10.3389/fmicb.2017.01256	2017
	Microevolution of Neisseria lactamica during nasopharyngeal colonisation induced by controlled human infection.	Pandey A, Cleary DW, Laver JR, Gorringe A, Deasy AM, Dale AP, Morris PD, Didelot X, Maiden MCJ, Read RC.	Nat Commun	10.1038/s41467-018-07235-5	2018
Metabolism	Safety, pharmacokinetics, and pharmacodynamics of ivacaftor in patients aged 2-5 years with cystic fibrosis and a CFTR gating mutation (KIWI): an open-label, single-arm study.	Davies JC, Cunningham S, Harris WT, Lapey A, Regelmann WE, Sawicki GS, Southern KW, Robertson S, Green Y, Cooke J, Rosenfeld M, KIWI Study Group.	Lancet Respir Med	10.1016/s2213-2600(15)00545-7	2016
Genetics	Interspecies Dissemination of a Mobilizable Plasmid Harboring blaIMP-19 and the Possibility of Horizontal Gene Transfer in a Single Patient.	Yamamoto M, Matsumura Y, Gomi R, Matsuda T, Tanaka M, Nagao M, Takakura S, Uemoto S, Ichiyama S.	Antimicrob Agents Chemother	10.1128/aac.00933-16	2016
	Species-specific and inhibitor-dependent conformations of LpxC: implications for antibiotic design.	Lee CJ, Liang X, Chen X, Zeng D, Joo SH, Chung HS, Barb AW, Swanson SM, Nicholas RA, Li Y, Toone EJ, Raetz CR, Zhou P.	Chem Biol	10.1016/j.chembiol.2010.11.011	2011
	Practical Approaches for Detecting Selection in Microbial Genomes.	Hedge J, Wilson DJ.	PLoS Comput Biol	10.1371/journal.pcbi.1004739	2016
Metabolism	A new means to identify type 3 secreted effectors: functionally interchangeable class IB chaperones recognize a conserved sequence.	Costa SC, Schmitz AM, Jahufar FF, Boyd JD, Cho MY, Glicksman MA, Lesser CF.	mBio	10.1128/mbio.00243-11	2012
Genetics	Escherichia coli Genomic Diversity within Extraintestinal Acute Infections Argues for Adaptive Evolution at Play.	Bridier-Nahmias A, Launay A, Bleibtreu A, Magnan M, Walewski V, Chatel J, Dion S, Robbe-Saule V, Clermont O, Norel F, Denamur E, Tenaillon O.	mSphere	10.1128/msphere.01176-20	2021
Metabolism	Molecular processes underlying synergistic linuron mineralization in a triple-species bacterial consortium biofilm revealed by differential transcriptomics.	Albers P, Weytjens B, De Mot R, Marchal K, Springael D.	Microbiologyopen	10.1002/mbo3.559	2018
Phylogeny	Parallel Evolution in Streptococcus pneumoniae Biofilms.	Churton NW, Misra RV, Howlin RP, Allan RN, Jefferies J, Faust SN, Gharbia SE, Edwards RJ, Clarke SC, Webb JS.	Genome Biol Evol	10.1093/gbe/evw072	2016
	Phenotypic delay in the evolution of bacterial antibiotic resistance: Mechanistic models and their implications.	Carballo-Pacheco M, Nicholson MD, Lilja EE, Allen RJ, Waclaw B.	PLoS Comput Biol	10.1371/journal.pcbi.1007930	2020
Genetics	Genome dynamics of multidrug-resistant Acinetobacter baumannii during infection and treatment.	Wright MS, Iovleva A, Jacobs MR, Bonomo RA, Adams MD.	Genome Med	10.1186/s13073-016-0279-y	2016
	Understanding the Pathogenicity of Burkholderia contaminans, an Emerging Pathogen in Cystic Fibrosis.	Nunvar J, Kalferstova L, Bloodworth RA, Kolar M, Degrossi J, Lubovich S, Cardona ST, Drevinek P.	PLoS One	10.1371/journal.pone.0160975	2016
	Vectors as Epidemiological Sentinels: Patterns of Within-Tick Borrelia burgdorferi Diversity.	Walter KS, Carpi G, Evans BR, Caccone A, Diuk-Wasser MA.	PLoS Pathog	10.1371/journal.ppat.1005759	2016
	Within-host bacterial diversity hinders accurate reconstruction of transmission networks from genomic distance data.	Worby CJ, Lipsitch M, Hanage WP.	PLoS Comput Biol	10.1371/journal.pcbi.1003549	2014
	Molecular longitudinal tracking of Mycobacterium abscessus spp. during chronic infection of the human lung.	Kreutzfeldt KM, McAdam PR, Claxton P, Holmes A, Seagar AL, Laurenson IF, Fitzgerald JR.	PLoS One	10.1371/journal.pone.0063237	2013
	High-throughput automated microfluidic sample preparation for accurate microbial genomics.	Kim S, De Jonghe J, Kulesa AB, Feldman D, Vatanen T, Bhattacharyya RP, Berdy B, Gomez J, Nolan J, Epstein S, Blainey PC.	Nat Commun	10.1038/ncomms13919	2017
	Burkholderia cepacia Complex Regulation of Virulence Gene Expression: A Review.	Sousa SA, Feliciano JR, Pita T, Guerreiro SI, Leitao JH.	Genes (Basel)	10.3390/genes8010043	2017
Metabolism	Lipidation of Class IV CdiA Effector Proteins Promotes Target Cell Recognition during Contact-Dependent Growth Inhibition.	Halvorsen TM, Garza-Sanchez F, Ruhe ZC, Bartelli NL, Chan NA, Nguyen JY, Low DA, Hayes CS.	mBio	10.1128/mbio.02530-21	2021
Pathogenicity	Investigating the Role of the Host Multidrug Resistance Associated Protein Transporter Family in Burkholderia cepacia Complex Pathogenicity Using a Caenorhabditis elegans Infection Model.	Tedesco P, Visone M, Parrilli E, Tutino ML, Perrin E, Maida I, Fani R, Ballestriero F, Santos R, Pinilla C, Di Schiavi E, Tegos G, de Pascale D.	PLoS One	10.1371/journal.pone.0142883	2015
Enzymology	A Single Amino Acid Replacement in the Sensor Kinase LiaS Contributes to a Carrier Phenotype in Group A Streptococcus.	Flores AR, Jewell BE, Yelamanchili D, Olsen RJ, Musser JM.	Infect Immun	10.1128/iai.00656-15	2015
Pathogenicity	Extensive horizontal gene transfer during Staphylococcus aureus co-colonization in vivo.	McCarthy AJ, Loeffler A, Witney AA, Gould KA, Lloyd DH, Lindsay JA.	Genome Biol Evol	10.1093/gbe/evu214	2014
Metabolism	Asymptomatic carriage of group A streptococcus is associated with elimination of capsule production.	Flores AR, Jewell BE, Olsen RJ, Shelburne SA, Fittipaldi N, Beres SB, Musser JM.	Infect Immun	10.1128/iai.01788-14	2014
	Elfamycins: inhibitors of elongation factor-Tu.	Prezioso SM, Brown NE, Goldberg JB.	Mol Microbiol	10.1111/mmi.13750	2017
	Within-host evolution of Staphylococcus aureus during asymptomatic carriage.	Golubchik T, Batty EM, Miller RR, Farr H, Young BC, Larner-Svensson H, Fung R, Godwin H, Knox K, Votintseva A, Everitt RG, Street T, Cule M, Ip CL, Didelot X, Peto TE, Harding RM, Wilson DJ, Crook DW, Bowden R.	PLoS One	10.1371/journal.pone.0061319	2013
	Infections in patients with cystic fibrosis: diagnostic microbiology update.	Gilligan PH.	Clin Lab Med	10.1016/j.cll.2014.02.001	2014
	Cyanide Toxicity to Burkholderia cenocepacia Is Modulated by Polymicrobial Communities and Environmental Factors.	Bernier SP, Workentine ML, Li X, Magarvey NA, O'Toole GA, Surette MG.	Front Microbiol	10.3389/fmicb.2016.00725	2016
	Dinoflagellate tandem array gene transcripts are highly conserved and not polycistronic.	Beauchemin M, Roy S, Roy S, Daoust P, Dagenais-Bellefeuille S, Bertomeu T, Letourneau L, Lang BF, Morse D.	Proc Natl Acad Sci U S A	10.1073/pnas.1206683109	2012
Genetics	Mechanistic model of Rothia mucilaginosa adaptation toward persistence in the CF lung, based on a genome reconstructed from metagenomic data.	Lim YW, Schmieder R, Haynes M, Furlan M, Matthews TD, Whiteson K, Poole SJ, Hayes CS, Low DA, Maughan H, Edwards R, Conrad D, Rohwer F.	PLoS One	10.1371/journal.pone.0064285	2013
Pathogenicity	Long-Term Evolution of Burkholderia multivorans during a Chronic Cystic Fibrosis Infection Reveals Shifting Forces of Selection.	Silva IN, Santos PM, Santos MR, Zlosnik JE, Speert DP, Buskirk SW, Bruger EL, Waters CM, Cooper VS, Moreira LM.	mSystems	10.1128/msystems.00029-16	2016
Genetics	Genome dynamics during experimental evolution.	Barrick JE, Lenski RE.	Nat Rev Genet	10.1038/nrg3564	2013
Genetics	Recombination is a key driver of genomic and phenotypic diversity in a Pseudomonas aeruginosa population during cystic fibrosis infection.	Darch SE, McNally A, Harrison F, Corander J, Barr HL, Paszkiewicz K, Holden S, Fogarty A, Crusz SA, Diggle SP.	Sci Rep	10.1038/srep07649	2015
Metabolism	A possible link between infection with burkholderia bacteria and systemic lupus erythematosus based on epitope mimicry.	Zhang W, Reichlin M.	Clin Dev Immunol	10.1155/2008/683489	2008
Metabolism	Burkholderia BcpA mediates biofilm formation independently of interbacterial contact-dependent growth inhibition.	Garcia EC, Anderson MS, Hagar JA, Cotter PA.	Mol Microbiol	10.1111/mmi.12339	2013
Phylogeny	Within-host evolution of Burkholderia pseudomallei over a twelve-year chronic carriage infection.	Price EP, Sarovich DS, Mayo M, Tuanyok A, Drees KP, Kaestli M, Beckstrom-Sternberg SM, Babic-Sternberg JS, Kidd TJ, Bell SC, Keim P, Pearson T, Currie BJ.	mBio	10.1128/mbio.00388-13	2013
Pathogenicity	The within-host population dynamics of Mycobacterium tuberculosis vary with treatment efficacy.	Trauner A, Liu Q, Via LE, Liu X, Ruan X, Liang L, Shi H, Chen Y, Wang Z, Liang R, Zhang W, Wei W, Gao J, Sun G, Brites D, England K, Zhang G, Gagneux S, Barry CE, Gao Q.	Genome Biol	10.1186/s13059-017-1196-0	2017
	Entry of Burkholderia organisms into respiratory epithelium: CFTR, microfilament and microtubule dependence.	Taylor JB, Hogue LA, LiPuma JJ, Walter MJ, Brody SL, Cannon CL.	J Cyst Fibros	10.1016/j.jcf.2009.10.002	2010
Phylogeny	A database of phylogenetically atypical genes in archaeal and bacterial genomes, identified using the DarkHorse algorithm.	Podell S, Gaasterland T, Allen EE.	BMC Bioinformatics	10.1186/1471-2105-9-419	2008
Metabolism	The unexpected discovery of a novel low-oxygen-activated locus for the anoxic persistence of Burkholderia cenocepacia.	Sass AM, Schmerk C, Agnoli K, Norville PJ, Eberl L, Valvano MA, Mahenthiralingam E.	ISME J	10.1038/ismej.2013.36	2013
Metabolism	Role of bacteriocins in mediating interactions of bacterial isolates taken from cystic fibrosis patients.	Bakkal S, Robinson SM, Ordonez CL, Waltz DA, Riley MA.	Microbiology (Reading)	10.1099/mic.0.036848-0	2010
Metabolism	Common duckweed (Lemna minor) is a versatile high-throughput infection model for the Burkholderia cepacia complex and other pathogenic bacteria.	Thomson EL, Dennis JJ, Dennis JJ.	PLoS One	10.1371/journal.pone.0080102	2013
Pathogenicity	Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of Caenorhabditis elegans.	Huber B, Feldmann F, Kothe M, Vandamme P, Wopperer J, Riedel K, Eberl L.	Infect Immun	10.1128/iai.72.12.7220-7230.2004	2004
Pathogenicity	Balancing Positive and Negative Selection: In Vivo Evolution of Candida lusitaniae MRR1.	Demers EG, Stajich JE, Ashare A, Occhipinti P, Hogan DA.	mBio	10.1128/mbio.03328-20	2021
Metabolism	Natural variation in the promoter of the gene encoding the Mga regulator alters host-pathogen interactions in group a Streptococcus carrier strains.	Flores AR, Olsen RJ, Wunsche A, Kumaraswami M, Shelburne SA, Carroll RK, Musser JM.	Infect Immun	10.1128/iai.00405-13	2013
Phylogeny	Phylogenetic reconstruction of the Legionella pneumophila Philadelphia-1 laboratory strains through comparative genomics.	Rao C, Benhabib H, Ensminger AW.	PLoS One	10.1371/journal.pone.0064129	2013
Metabolism	Response of Burkholderia cenocepacia H111 to micro-oxia.	Pessi G, Braunwalder R, Grunau A, Omasits U, Ahrens CH, Eberl L.	PLoS One	10.1371/journal.pone.0072939	2013
Metabolism	A type IV secretion system contributes to intracellular survival and replication of Burkholderia cenocepacia.	Sajjan SU, Carmody LA, Gonzalez CF, LiPuma JJ.	Infect Immun	10.1128/iai.00451-08	2008
Enzymology	Isolation and characterization of a novel haloacid permease from Burkholderia cepacia MBA4.	Yu M, Faan YW, Chung WY, Tsang JS.	Appl Environ Microbiol	10.1128/aem.00576-07	2007
Pathogenicity	The antimicrobial efficacy of sustained release silver-carbene complex-loaded L-tyrosine polyphosphate nanoparticles: characterization, in vitro and in vivo studies.	Hindi KM, Ditto AJ, Panzner MJ, Medvetz DA, Han DS, Hovis CE, Hilliard JK, Taylor JB, Yun YH, Cannon CL, Youngs WJ.	Biomaterials	10.1016/j.biomaterials.2009.03.044	2009
Phylogeny	Development of a species-specific fur gene-based method for identification of the Burkholderia cepacia complex.	Lynch KH, Dennis JJ, Dennis JJ.	J Clin Microbiol	10.1128/jcm.01460-07	2008
	Tangled bank of experimentally evolved Burkholderia biofilms reflects selection during chronic infections.	Traverse CC, Mayo-Smith LM, Poltak SR, Cooper VS.	Proc Natl Acad Sci U S A	10.1073/pnas.1207025110	2013
Metabolism	Elucidation of the regulon and cis-acting regulatory element of HrpB, the AraC-type regulator of a plant pathogen-like type III secretion system in Burkholderia pseudomallei.	Lipscomb L, Schell MA.	J Bacteriol	10.1128/jb.01379-10	2011
Metabolism	Identification of novel type III secretion chaperone-substrate complexes of Chlamydia trachomatis.	Pais SV, Milho C, Milho C, Almeida F, Mota LJ.	PLoS One	10.1371/journal.pone.0056292	2013
Phenotype	Characterization of nontypable Haemophilus influenzae isolates recovered from adult patients with underlying chronic lung disease reveals genotypic and phenotypic traits associated with persistent infection.	Garmendia J, Viadas C, Calatayud L, Mell JC, Marti-Lliteras P, Euba B, Llobet E, Gil C, Bengoechea JA, Redfield RJ, Linares J.	PLoS One	10.1371/journal.pone.0097020	2014
Pathogenicity	Glyphosate resistance as a novel select-agent-compliant, non-antibiotic-selectable marker in chromosomal mutagenesis of the essential genes asd and dapB of Burkholderia pseudomallei.	Norris MH, Kang Y, Lu D, Wilcox BA, Hoang TT.	Appl Environ Microbiol	10.1128/aem.00820-09	2009
Phylogeny	characterization of bacterial community diversity in cystic fibrosis lung infections by use of 16s ribosomal DNA terminal restriction fragment length polymorphism profiling.	Rogers GB, Carroll MP, Serisier DJ, Hockey PM, Jones G, Bruce KD.	J Clin Microbiol	10.1128/jcm.42.11.5176-5183.2004	2004
	The Burkholderia bcpAIOB genes define unique classes of two-partner secretion and contact dependent growth inhibition systems.	Anderson MS, Garcia EC, Cotter PA.	PLoS Genet	10.1371/journal.pgen.1002877	2012
Phylogeny	Genomic analysis and relatedness of P2-like phages of the Burkholderia cepacia complex.	Lynch KH, Stothard P, Dennis JJ, Dennis JJ.	BMC Genomics	10.1186/1471-2164-11-599	2010
Genetics	A Primer on Infectious Disease Bacterial Genomics.	Lynch T, Petkau A, Knox N, Graham M, Van Domselaar G.	Clin Microbiol Rev	10.1128/cmr.00001-16	2016
	Use of suppression-subtractive hybridization to identify genes in the Burkholderia cepacia complex that are unique to Burkholderia cenocepacia.	Bernier SP, Sokol PA.	J Bacteriol	10.1128/jb.187.15.5278-5291.2005	2005
Phylogeny	Proposal to accommodate Burkholderia cepacia genomovar VI as Burkholderia dolosa sp. nov.	Vermis K, Coenye T, LiPuma JJ, Mahenthiralingam E, Nelis HJ, Vandamme P	Int J Syst Evol Microbiol	10.1099/ijs.0.02888-0	2004

References

#6284	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 16088
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#30053	Barberan A, Caceres Velazquez H, Jones S, Fierer N.: Hiding in Plain Sight: Mining Bacterial Species Records for Phenotypic Trait Information. mSphere 2: 2017 ( DOI 10.1128/mSphere.00237-17 , PubMed 28776041 ) - originally annotated from #26414 (see below)
#36729	; Curators of the CIP;
#57842	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 47727
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68369	Automatically annotated from API 20NE .
#68382	Automatically annotated from API zym .
#118960	Collection of Institut Pasteur ; Curators of the CIP; CIP 108406
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Burkholderia dolosa (DSM 16088, CCUG 47727, LMG 18943)

Name and taxonomic classification