Akkermansia muciniphila (DSM 22959, ATCC BAA-835, CIP 107961)

Name: Akkermansia muciniphila (DSM 22959, ATCC BAA-835, CIP 107961)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 17849

Type strain

Strain Designation Muc, MucT

Culture col. no. DSM 22959 ATCC BAA-835 CIP 107961 CCUG 64013 JCM 33894 3 more

NCBI tax ID(s) 349741 239935

Special Collections DSMZ CCUG JCM CIP

History DSMZ <- CIP <- M. Derrien, Lab. Microbiology, Wageningen Univ., Netherlands; Muc CIP <- 2003, M. Derrien, Wageningen, The Netherlands: strain MucT JCM <-- DSM 22959 <-- CIP 107961 <-- M. Derrien; Lab. Microbiol, Wageningen Univ., Netherlands; Muc. CIP <- 2003, M. Derrien, Wageningen, The Netherlands: strain MucT

Links

Akkermansia muciniphila Muc is an anaerobe, Gram-negative, rod-shaped bacterium that was isolated from human intestinal tract .

Gram-negative rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 134273

LMG 27907,DSM 22959,JCM 33894,ATCC BAA-835,CIP 107961,CCUG 64013

@ref 20215

Last LPSN update 2026-05-29 08:29:06

Domain Bacteria

Phylum Verrucomicrobiota

Class Verrucomicrobiia

Order Verrucomicrobiales

Family Akkermansiaceae

Genus Akkermansia

Species Akkermansia muciniphila

Full scientific name Akkermansia muciniphila Derrien et al. 2004

BacDive ID	Other strains from **Akkermansia muciniphila** (2)	Type strain
131145	A. muciniphila YL44, DSM 26127
163900	A. muciniphila JCM 30893

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
125438	negative			95.206
121158	negative	rod-shaped

Colony morphology

16637

Incubation period3-7 days

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
16637	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)	Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water
16637	SCHAEDLER BROTH (ROTH; 5772) (DSMZ Medium 1669)	Medium recipe at MediaDive	Name: SCHAEDLER BROTH (Roth; 5772) (DSMZ Medium 1669) Composition: Glucose 5.83 g/l Casein peptone 5.66 g/l Yeast extract 5.0 g/l Peptone mixture 5.0 g/l Tris 3.0 g/l NaCl 1.66 g/l Soy peptone 1.0 g/l K2HPO4 0.83 g/l L-Cysteine HCl x H2O 0.4 g/l Hemin 0.01 g/l Resazurin 0.001 g/l Distilled water
40737	MEDIUM 187 - for anaerobic bacteria		Distilled water make up to (1000.000 ml);Glucose (5.000 g);Yeast extract(20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);Hemin solution - M00149(25.000 ml)
121158	CIP Medium 20	Medium recipe at CIP
121158	CIP Medium 486	Medium recipe at CIP
121158	CIP Medium 187	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
16637	positive	growth	37
40737	positive	growth	37
63059	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
16637	anaerobe
63059	anaerobe
125439	facultative anaerobe	93.842

Spore formation

@ref	Spore formation	Confidence
125439		97.177

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
121158	17632 ChEBI	nitrate	-	reduction
121158	16301 ChEBI	nitrite	-	reduction
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A
121158	35581 ChEBI	indole

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	-	3.1.3.2	from API zym
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68380	alkaline phosphatase	-	3.1.3.1	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68382	alpha-galactosidase	-	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68380	alpha-glucosidase	-	3.2.1.20	from API rID32A
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68382	beta-galactosidase	+	3.2.1.23	from API zym
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68382	beta-glucosidase	-	3.2.1.21	from API zym
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68382	beta-glucuronidase	-	3.2.1.31	from API zym
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
121158	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	-		from API zym
68382	esterase lipase (C 8)	-		from API zym
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68382	leucine arylamidase	-	3.4.11.1	from API zym
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
121158	oxidase	-
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68382	trypsin	-	3.4.21.4	from API zym
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
121158	urease	-	3.5.1.5
68380	urease	-	3.5.1.5	from API rID32A
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
121158	-	-	-	-	-	-	-	-	-	-	-	-	-	+	-	-	-	+	-	-

API rID32A

@ref	URE	ADH (Arg)	alpha GAL	beta GAL	beta-Galactosidase 6-phosphatebeta GP	alpha GLU	beta GLU	alpha ARA	beta GUR	beta-N-Acetyl-beta-glucosaminidasebeta NAG	MNE	RAF	GDC	alpha FUC	Reduction of nitrateNIT	IND	PAL	L-arginine arylamidaseArgA	ProA	LGA	Phenylalanine arylamidasePheA	Leucine arylamidaseLeuA	PyrA	Tyrosine arylamidaseTyrA	Alanine arylamidaseAlaA	Glycin arylamidaseGlyA	Histidine arylamidaseHisA	Glutamyl-glutamate arylamidaseGGA	Serine arylamidaseSerA
16637	-	-	+	+	-	-	-	-	-	+	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	-	+/-	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+/-	+	-	-	-	-	-	+	-	-	+	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+/-	-	-	+	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	+	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-
16637	-	-	+	+	-	-	-	-	-	+	-	-	+	-	-	-	-	+	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Host	#Human	-
#Host Body Product	#Gastrointestinal tract	#Feces (Stool)

Isolation

@ref	Sample type	Host species	Sampling date	Country	Country ISO 3 Code	Continent	Isolation date
16637	human intestinal tract (feces)	Homo sapiens		Netherlands	NLD	Europe
63059	Human feces	Homo sapiens	2002-03-01	Netherlands	NLD	Europe
67770	Human feces from a healthy adult volunteer	Homo sapiens		Netherlands	NLD	Europe
121158	Human, Feces	Homo sapiens		Netherlands	NLD	Europe	2002

Taxonmaps

69479

Global distribution of 16S sequence AY271254 (>99% sequence identity) for Akkermansia muciniphila subclade from Microbeatlas

Aquatic Samples	4383
Soil Samples	1656
Animal Samples	128875
Plant Samples	623
Total Samples	135537

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
16637	1	Risk group (German classification) According to TRBA 466
121158	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
124043	ASM1750414v1 assembly for Akkermansia muciniphila ATCC BAA-835	complete	GCA_017504145			349741	99.8
67770	ASM2022v1 assembly for Akkermansia muciniphila ATCC BAA-835	complete	GCA_000020225	349741.6	642555104	349741	99.66
66792	ASM800097v1 assembly for Akkermansia muciniphila DSM 22959	complete	GCA_008000975	239935.2131	8111649474	239935	99.62

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
16637	Akkermansia muciniphila strain Muc 16S ribosomal RNA gene, complete sequence	AY271254	1433		349741
124043	Akkermansia muciniphila strain ATCC BAA-835 16S ribosomal RNA gene, partial sequence.	OP143661	1365		239935

GC content

@ref	GC-content (mol%)	Method
16637	47.6
16637	55.8	sequence analysis
67770	47.6	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: ASM1750414v1 assembly for Akkermansia muciniphila ATCC BAA-835
NCBI: GCA_017504145

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	gram_stain	BacteriaNetⓘ	negative	89.14	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	93.84	no
125439	motility	BacteriaNetⓘ	yes	51.94	no
125439	spore_formation	BacteriaNetⓘ	no	97.18	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Akkermansia muciniphila DSM 22959
NCBI: GCA_008000975.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	95.21	no
125438	anaerobic	anaerobicⓘ	yes	74.85	yes
125438	aerobic	aerobicⓘ	no	84.69	no
125438	spore-forming	spore-formingⓘ	no	88.13	no
125438	thermophilic	thermophileⓘ	no	93.00	yes
125438	flagellated	motile2+ⓘ	no	83.46	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Utilization of Ningxiang pig milk oligosaccharides by Akkermansia muciniphila in vitro fermentation: enhancing neonatal piglet survival.	Zhang L, Wu Z, Kang M, Wang J, Tan B.	Front Microbiol	10.3389/fmicb.2024.1430276	2024
	Strain-Specific Safety Evaluation of Akkermansia muciniphila Akk11: Comprehensive Genotypic, Phenotypic, and Toxicological Assessment.	Wang X, Fan Y, Dong Y, Zhang Y, Tan X, Gai Z, Sun Y, Fang S.	Food Sci Nutr	10.1002/fsn3.71154	2025
	Incorporation of Bifidobacterium animalis subspecies lactis BB-12® and Akkermansia muciniphila in chocolate matrices	Vedor R, Machado D, Barbosa JC, Almeida D, Gomes AM.	Lebensm Wiss Technol		2023
	Akkermansia muciniphila Encapsulated in Calcium-Alginate Hydrogelated Matrix: Viability and Stability over Aerobic Storage and Simulated Gastrointestinal Conditions.	Machado D, Fonseca M, Vedor R, Sousa S, Barbosa JC, Gomes AM.	Gels	10.3390/gels9110869	2023
	Lacticaseibacillus rhamnosus GR-1 prevents autism-like behaviors by reshaping the maternal and offspring microbiome.	Yang R, Xu Y, Xu J, Huang C, Zhu F, Wang T, Kong R, Xiao J, He B, Gu X, Wang HL.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00808-5	2025
	Akkermansia muciniphila: new insights into resistance to gastrointestinal stress, adhesion, and protein interaction with human mucins through optimised in vitro trials and bioinformatics tools.	Vergalito F, Bagnoli D, Maiuro L, Pannella G, Palombo V, Testa B, Coppola F, Di Marco RMA, Tremonte P, Lombardi SJ, Iorizzo M, Coppola R, Succi M.	Front Microbiol	10.3389/fmicb.2024.1462220	2024
	Akkermansia muciniphila ONE effectively ameliorates dextran sulfate sodium (DSS)-induced ulcerative colitis in mice.	Zhang H, Pan Y, Jiang Y, Chen M, Ma X, Yu X, Ren D, Jiang B.	NPJ Sci Food	10.1038/s41538-024-00339-x	2024
Genetics	Investigation of Intestinal Microbiota and Short-Chain Fatty Acids in Colorectal Cancer and Detection of Biomarkers.	Saylam E, Ozden O, Yerlikaya FH, Sivrikaya A, Yormaz S, Arslan U, Topkafa M, Macin S.	Pathogens	10.3390/pathogens14090953	2025
	Probiotic administration aggravates dextran sulfate sodium salt-induced inflammation and intestinal epithelium disruption in weaned pig.	Xie K, Cai W, Li L, Yu B, Luo Y, Huang Z, Mao X, Yu J, Zheng P, Yan H, Li H, He J.	Anim Microbiome	10.1186/s42523-024-00375-8	2025
	Function and therapeutic prospects of next-generation probiotic Akkermansia muciniphila in infectious diseases.	Li L, Li M, Chen Y, Yu Z, Cheng P, Yu Z, Cheng W, Zhang W, Wang Z, Gao X, Sun H, Wang X.	Front Microbiol	10.3389/fmicb.2024.1354447	2024
Pathogenicity	Development and characterization of a chicory extract fermented by Akkermansia muciniphila: An in vitro study on its potential to modulate obesity-related inflammation.	Chervet A, Nehme R, Defois-Fraysse C, Decombat C, Blavignac C, Auxenfans C, Evrard B, Michel S, Filaire E, Berthon JY, Dreux-Zigha A, Delort L, Caldefie-Chezet F.	Curr Res Food Sci	10.1016/j.crfs.2025.100974	2025
Genetics	Genome- and Toxicology-Based Safety Assessment of Probiotic Akkermansia muciniphila ONE Isolated from Humans.	Lv N, Wang C, Zhou H, Ma X, Yu X, Ren D.	Foods	10.3390/foods13131979	2024
	Milk and mucin glycans orchestrate a synthetic infant gut microbiota structure.	Berkhout MD, Ioannou A, Kavanal Jayaprakash Y, Plugge CM, Belzer C.	FEMS Microbiol Ecol	10.1093/femsec/fiaf069	2025
	Vitamin B12 analogues from gut microbes and diet differentially impact commensal propionate producers of the human gut.	Kundra P, Greppi A, Duppenthaler M, Pluss S, Pugin B, Lacroix C, Geirnaert A.	Front Nutr	10.3389/fnut.2024.1360199	2024
	Lack of genotoxicity and subchronic toxicity in safety assessment studies of Akkermansia muciniphila formulation.	Yu E, Eid J, Cheng A, Lynch B, Bauter M.	Toxicol Rep	10.1016/j.toxrep.2024.101790	2024
	Effects of Early Life Exposures to the Aryl Hydrocarbon Receptor Ligand TCDF on Gut Microbiota and Host Metabolic Homeostasis in C57BL/6J Mice.	Tian Y, Rimal B, Bisanz JE, Gui W, Wolfe TM, Koo I, Murray IA, Nettleford SK, Yokoyama S, Dong F, Koshkin S, Prabhu KS, Turnbaugh PJ, Walk ST, Perdew GH, Patterson AD.	Environ Health Perspect	10.1289/ehp13356	2024
	Diet-driven differential response of Akkermansia muciniphila modulates pathogen susceptibility.	Wolter M, Grant ET, Boudaud M, Pudlo NA, Pereira GV, Eaton KA, Martens EC, Desai MS.	Mol Syst Biol	10.1038/s44320-024-00036-7	2024
Metabolism	Impaired Fat Absorption from Intestinal Tract in High-Fat Diet Fed Male Mice Deficient in Proglucagon-Derived Peptides.	Nishida K, Ueno S, Seino Y, Hidaka S, Murao N, Asano Y, Fujisawa H, Shibata M, Takayanagi T, Ohbayashi K, Iwasaki Y, Iizuka K, Okuda S, Tanaka M, Fujii T, Tochio T, Yabe D, Yamada Y, Sugimura Y, Hirooka Y, Hayashi Y, Suzuki A.	Nutrients	10.3390/nu16142270	2024
	Distinct in vitro utilization and degradation of porcine gastric mucin glycans by human intestinal bacteria.	de Ram C, Berkhout MD, O Pandeirada C, Vincken JP, Hooiveld GJEJ, Belzer C, Schols HA.	FEMS Microbiol Ecol	10.1093/femsec/fiaf066	2025
Genetics	Whole-genome sequencing and genomic analysis of four Akkermansia strains newly isolated from human feces.	Lu W, Zha B, Lyu J, LingHu C, Chen J, Deng S, Zhang X, Li L, Wang G.	Front Microbiol	10.3389/fmicb.2024.1500886	2024
	Physiology of gamma-aminobutyric acid production by Akkermansia muciniphila.	Konstanti P, Ligthart K, Fryganas C, Constantinos P, Smidt H, de Vos WM, Belzer C.	Appl Environ Microbiol	10.1128/aem.01121-23	2024
Phylogeny	Exploring the resilience and stability of a defined human gut microbiota consortium: An isothermal microcalorimetric study.	Kattel A, Aro V, Lahtvee PJ, Kazantseva J, Joers A, Nahku R, Belouah I.	Microbiologyopen	10.1002/mbo3.1430	2024
	Probiotics as Antioxidant Strategy for Managing Diabetes Mellitus and Its Complications.	Viana MDM, Santos SS, Cruz ABO, de Jesus MVAC, Lauria PSS, Lins MP, Villarreal CF.	Antioxidants (Basel)	10.3390/antiox14070767	2025
	Possible application of Akkermansia muciniphila in stress management.	Misera A, Marlicz W, Podkowka A, Loniewski I, Skonieczna-Zydecka K.	Microbiome Res Rep	10.20517/mrr.2023.81	2024
	The role of microbiota in nonalcoholic fatty liver disease: mechanism of action and treatment strategy	Shen S, Liu Y, Wang N, Huang Z, Deng G.	Front Microbiol		2025
Enzymology	In situ identifying sennoside A-reducing bacteria guilds in human gut microbiota via enzymatic activity visualization.	Zhai C, Liu X, Liu Z, Ma H, Li H, Gong Y, Li X, Wang Y, Zhang N, Zhang H, Luo G, Wang Y, Gao X.	Gut Microbes	10.1080/19490976.2025.2560598	2025
	Next-generation probiotic candidates targeting intestinal health in weaned piglets: Both live and heat-killed Akkermansia muciniphila prevent pathological changes induced by enterotoxigenic Escherichia coli in the gut.	Lan C, Li H, Shen Y, Liu Y, Wu A, He J, Cai J, Tian G, Mao X, Huang Z, Yu B, Zheng P, Yu J, Luo J, Yan H, Luo Y.	Anim Nutr	10.1016/j.aninu.2024.01.007	2024
Genetics	Characterization and Preliminary Safety Evaluation of Akkermansia muciniphila PROBIO.	Ma X, Tian M, Yu X, Liu M, Li B, Ren D, Wang W.	Foods	10.3390/foods13030442	2024
	Protocol for rapid obtention and fractionation of anaerobic bacterial conditioned media to study calcium signaling in enteroendocrine cells.	Amorim Neto DP, de Castro Fonseca M.	STAR Protoc	10.1016/j.xpro.2022.101486	2022
	A Gnotobiotic Mouse Model with Divergent Equol-Producing Phenotypes: Potential for Determining Microbial-Driven Health Impacts of Soy Isoflavone Daidzein.	Leonard LM, Simpson AMR, Li S, Reddivari L, Cross TL.	Nutrients	10.3390/nu16071079	2024
	Akkermansia muciniphila in inflammatory bowel disease and colorectal cancer.	Gu ZY, Pei WL, Zhang Y, Zhu J, Li L, Zhang Z.	Chin Med J (Engl)	10.1097/cm9.0000000000001829	2021
	Clostridium butyricum and Clostridium tyrobutyricum: angel or devil for necrotizing enterocolitis?	Tao R, Zong G, Pan Y, Li H, Cheng P, Deng R, Chen W, Wang A, Xia S, Tang W, Lu Y, Wei Z.	mSystems	10.1128/msystems.00732-23	2023
	Rational consideration of Akkermansia muciniphila targeting intestinal health: advantages and challenges.	Luo Y, Lan C, Li H, Ouyang Q, Kong F, Wu A, Ren Z, Tian G, Cai J, Yu B, He J, Wright AG.	NPJ Biofilms Microbiomes	10.1038/s41522-022-00338-4	2022
	Safety Evaluation and Probiotic Potency Screening of Akkermansia muciniphila Strains Isolated from Human Feces and Breast Milk.	Hou F, Tang J, Liu Y, Tan Y, Wang Y, Zheng L, Liang D, Lin Y, Wang L, Pan Z, Yang R, Bi Y, Zhi F.	Microbiol Spectr	10.1128/spectrum.03361-22	2023
	Akkermansia muciniphila Alters Gut Microbiota and Immune System to Improve Cardiovascular Diseases in Murine Model.	He X, Bai Y, Zhou H, Wu K.	Front Microbiol	10.3389/fmicb.2022.906920	2022
	Exploring Next Generation Probiotics for Metabolic and Microbiota Dysbiosis Linked to Xenobiotic Exposure: Holistic Approach.	Torres-Sanchez A, Ruiz-Rodriguez A, Ortiz P, Moreno MA, Ampatzoglou A, Gruszecka-Kosowska A, Monteoliva-Sanchez M, Aguilera M.	Int J Mol Sci	10.3390/ijms232112917	2022
	Akkermansia muciniphila inhibited the periodontitis caused by Fusobacterium nucleatum.	Song B, Xian W, Sun Y, Gou L, Guo Q, Zhou X, Ren B, Cheng L.	NPJ Biofilms Microbiomes	10.1038/s41522-023-00417-0	2023
	Recent Advances in the Understanding of Stress Resistance Mechanisms in Probiotics: Relevance for the Design of Functional Food Systems.	Bustos AY, Taranto MP, Gerez CL, Agriopoulou S, Smaoui S, Varzakas T, Enshasy HAE.	Probiotics Antimicrob Proteins	10.1007/s12602-024-10273-9	2025
	Akkermansia muciniphila induces mitochondrial calcium overload and alpha -synuclein aggregation in an enteroendocrine cell line.	Amorim Neto DP, Bosque BP, Pereira de Godoy JV, Rodrigues PV, Meneses DD, Tostes K, Costa Tonoli CC, Faustino de Carvalho H, Gonzalez-Billault C, de Castro Fonseca M.	iScience	10.1016/j.isci.2022.103908	2022
	Phylogenetic diversity of core rumen microbiota as described by cryo-ET.	Wimmer BH, Morais S, Zalk R, Mizrahi I, Medalia O.	Microlife	10.1093/femsml/uqad010	2023
	T-cell activation Rho GTPase-activating protein maintains intestinal homeostasis by regulating intestinal T helper cells differentiation through the gut microbiota.	He R, Chen J, Zhao Z, Shi C, Du Y, Yi M, Feng L, Peng Q, Cui Z, Gao R, Wang H, Huang Y, Liu Z, Wang C.	Front Microbiol	10.3389/fmicb.2022.1030947	2022
	Akkermansia muciniphila Protects Against Psychological Disorder-Induced Gut Microbiota-Mediated Colonic Mucosal Barrier Damage and Aggravation of Colitis.	Chen T, Wang R, Duan Z, Yuan X, Ding Y, Feng Z, Bu F, Liu L, Wang Q, Zhou J, Zhu L, Ni Q, Shi G, Chen Y.	Front Cell Infect Microbiol	10.3389/fcimb.2021.723856	2021
	Maternal diet and gut microbiome composition modulate early-life immune development.	Grant ET, Boudaud M, Muller A, Muller A, Macpherson AJ, Desai MS.	EMBO Mol Med	10.15252/emmm.202217241	2023
Transcriptome	The effect of bile acids on the growth and global gene expression profiles in Akkermansia muciniphila.	Hagi T, Geerlings SY, Nijsse B, Belzer C.	Appl Microbiol Biotechnol	10.1007/s00253-020-10976-3	2020
Phylogeny	Pangenomic analysis identifies correlations between Akkermansia species and subspecies and human health outcomes.	Mueller KD, Panzetta ME, Davey L, McCann JR, Rawls JF, Flores GE, Valdivia RH.	Microbiome Res Rep	10.20517/mrr.2024.09	2024
	[Protective Effects of Akkermansia muciniphila and Amuc_1100 Protein on Rats on High-Fat Diet Combined with Streptozotocin Injection].	Deng SS, Chen J, Liu X, Dong XY, Zhang XL, Wang GQ.	Sichuan Da Xue Xue Bao Yi Xue Ban	10.12182/20220160304	2022
	Sialidases and fucosidases of Akkermansia muciniphila are crucial for growth on mucin and nutrient sharing with mucus-associated gut bacteria.	Shuoker B, Pichler MJ, Jin C, Sakanaka H, Wu H, Gascuena AM, Liu J, Nielsen TS, Holgersson J, Nordberg Karlsson E, Juge N, Meier S, Morth JP, Karlsson NG, Abou Hachem M.	Nat Commun	10.1038/s41467-023-37533-6	2023
Pathogenicity	Altered gut microbiota of obesity subjects promotes colorectal carcinogenesis in mice.	Kang X, Ng SK, Liu C, Lin Y, Zhou Y, Kwong TNY, Ni Y, Lam TYT, Wu WKK, Wei H, Sung JJY, Yu J, Wong SH.	EBioMedicine	10.1016/j.ebiom.2023.104670	2023
	The secreted protein Amuc_1409 from Akkermansia muciniphila improves gut health through intestinal stem cell regulation.	Kang EJ, Kim JH, Kim YE, Lee H, Jung KB, Chang DH, Lee Y, Park S, Lee EY, Lee EJ, Kang HB, Rhyoo MY, Seo S, Park S, Huh Y, Go J, Choi JH, Choi YK, Lee IB, Choi DH, Seo YJ, Noh JR, Kim KS, Hwang JH, Jeong JS, Kwon HJ, Yoo HM, Son MY, Kim YG, Lee DH, Kim TY, Kwon HJ, Kim MH, Kim BC, Kim YH, Kang D, Lee CH.	Nat Commun	10.1038/s41467-024-47275-8	2024
Phylogeny	Comprehensive 16S rRNA and metagenomic data from the gut microbiome of aging and rejuvenation mouse models.	Shin J, Noh JR, Choe D, Lee N, Song Y, Cho S, Kang EJ, Go MJ, Ha SK, Kim JH, Kim YH, Kim KS, Kim BC, Lee CH, Cho BK.	Sci Data	10.1038/s41597-022-01308-3	2022
	Proanthocyanidin-enriched cranberry extract induces resilient bacterial community dynamics in a gnotobiotic mouse model.	Neto CC, Mortzfeld BM, Turbitt JR, Bhattarai SK, Yeliseyev V, DiBenedetto N, Bry L, Bucci V.	Microb Cell	10.15698/mic2021.06.752	2021
Pathogenicity	Active or Autoclaved Akkermansia muciniphila Relieves TNF-alpha-Induced Inflammation in Intestinal Epithelial Cells Through Distinct Pathways.	Luo Y, Lan C, Xie K, Li H, Devillard E, He J, Liu L, Cai J, Tian G, Wu A, Ren Z, Chen D, Yu B, Huang Z, Zheng P, Mao X, Yu J, Luo J, Yan H, Wang Q, Wang H, Tang J.	Front Immunol	10.3389/fimmu.2021.788638	2021
	Downregulation of ACE, AGTR1, and ACE2 genes mediating SARS-CoV-2 pathogenesis by gut microbiota members and their postbiotics on Caco-2 cells.	Ahmadi Badi S, Malek A, Paolini A, Rouhollahi Masoumi M, Seyedi SA, Amanzadeh A, Masotti A, Khatami S, Siadat SD.	Microb Pathog	10.1016/j.micpath.2022.105798	2022
	Specific gFET-Based Aptasensors for Monitoring of Microbiome Quality: Quantification of the Enteric Health-Relevant Bacterium Roseburia Intestinalis.	Zhang Y, Xing H, Li R, Andersson J, Bozdogan A, Strassl R, Draphoen B, Linden M, Henkel M, Knippschild U, Hasler R, Kleber C, Knoll W, Kissmann AK, Rosenau F.	Adv Healthc Mater	10.1002/adhm.202403827	2025
Metabolism	Transcriptomics and metabolomics reveal the adaption of Akkermansia muciniphila to high mucin by regulating energy homeostasis.	Liu X, Zhao F, Liu H, Xie Y, Zhao D, Li C.	Sci Rep	10.1038/s41598-021-88397-z	2021
	Mucosal glycan degradation of the host by the gut microbiota.	Bell A, Juge N.	Glycobiology	10.1093/glycob/cwaa097	2021
Pathogenicity	Abiraterone acetate preferentially enriches for the gut commensal Akkermansia muciniphila in castrate-resistant prostate cancer patients.	Daisley BA, Chanyi RM, Abdur-Rashid K, Al KF, Gibbons S, Chmiel JA, Wilcox H, Reid G, Anderson A, Dewar M, Nair SM, Chin J, Burton JP.	Nat Commun	10.1038/s41467-020-18649-5	2020
Transcriptome	Simplified Intestinal Microbiota to Study Microbe-Diet-Host Interactions in a Mouse Model.	Kovatcheva-Datchary P, Shoaie S, Lee S, Wahlstrom A, Nookaew I, Hallen A, Perkins R, Nielsen J, Backhed F.	Cell Rep	10.1016/j.celrep.2019.02.090	2019
	Versatility of bacterial outer membrane vesicles in regulating intestinal homeostasis.	Wang X, Lin S, Wang L, Cao Z, Zhang M, Zhang Y, Liu R, Liu J.	Sci Adv	10.1126/sciadv.ade5079	2023
	Mucolytic bacteria license pathobionts to acquire host-derived nutrients during dietary nutrient restriction.	Sugihara K, Kitamoto S, Saraithong P, Nagao-Kitamoto H, Hoostal M, McCarthy C, Rosevelt A, Muraleedharan CK, Gillilland MG, Imai J, Omi M, Bishu S, Kao JY, Alteri CJ, Barnich N, Schmidt TM, Nusrat A, Inohara N, Golob JL, Kamada N.	Cell Rep	10.1016/j.celrep.2022.111093	2022
Metabolism	Prevalent Human Gut Bacteria Hydrolyse and Metabolise Important Food-Derived Mycotoxins and Masked Mycotoxins.	Daud N, Currie V, Duncan G, Farquharson F, Yoshinari T, Louis P, Gratz S.	Toxins (Basel)	10.3390/toxins12100654	2020
	Xylanase enhances gut microbiota-derived butyrate to exert immune-protective effects in a histone deacetylase-dependent manner.	Wang T, Zhou N, Ding F, Hao Z, Galindo-Villegas J, Du Z, Su X, Zhang M.	Microbiome	10.1186/s40168-024-01934-6	2024
Metabolism	Identification of a Novel Cobamide Remodeling Enzyme in the Beneficial Human Gut Bacterium Akkermansia muciniphila.	Mok KC, Sokolovskaya OM, Nicolas AM, Hallberg ZF, Deutschbauer A, Carlson HK, Taga ME.	mBio	10.1128/mbio.02507-20	2020
	Propionate-Producing Consortium Restores Antibiotic-Induced Dysbiosis in a Dynamic in vitro Model of the Human Intestinal Microbial Ecosystem.	El Hage R, Hernandez-Sanabria E, Calatayud Arroyo M, Props R, Van de Wiele T.	Front Microbiol	10.3389/fmicb.2019.01206	2019
	Short-chain fatty acid-producing bacterial strains attenuate experimental ulcerative colitis by promoting M2 macrophage polarization via JAK/STAT3/FOXO3 axis inactivation.	Zhao H, Zhou Y, Xu J, Zhang Y, Wang H, Zhao C, Huang H, Yang J, Huang C, Li Y, Wang L, Nie Y.	J Transl Med	10.1186/s12967-024-05122-w	2024
Pathogenicity	Constructing a gnotobiotic mouse model with a synthetic human gut microbiome to study host-microbe cross talk.	Steimle A, De Sciscio A, Neumann M, Grant ET, Pereira GV, Ohno H, Martens EC, Desai MS.	STAR Protoc	10.1016/j.xpro.2021.100607	2021
	The immunotoxicity, but not anti-tumor efficacy, of anti-CD40 and anti-CD137 immunotherapies is dependent on the gut microbiota.	Blake SJ, James J, Ryan FJ, Caparros-Martin J, Eden GL, Tee YC, Salamon JR, Benson SC, Tumes DJ, Sribnaia A, Stevens NE, Finnie JW, Kobayashi H, White DL, Wesselingh SL, O'Gara F, Lynn MA, Lynn DJ.	Cell Rep Med	10.1016/j.xcrm.2021.100464	2021
	Assessment of Gram- and Viability-Staining Methods for Quantifying Bacterial Community Dynamics Using Flow Cytometry.	Duquenoy A, Bellais S, Gasc C, Schwintner C, Dore J, Thomas V.	Front Microbiol	10.3389/fmicb.2020.01469	2020
	How microbial glycosyl hydrolase activity in the gut mucosa initiates microbial cross-feeding.	Berkhout MD, Plugge CM, Belzer C.	Glycobiology	10.1093/glycob/cwab105	2022
Metabolism	Biochemical and structural basis of sialic acid utilization by gut microbes.	Bell A, Severi E, Owen CD, Latousakis D, Juge N.	J Biol Chem	10.1016/j.jbc.2023.102989	2023
Metabolism	Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways.	Pichler MJ, Yamada C, Shuoker B, Alvarez-Silva C, Gotoh A, Leth ML, Schoof E, Katoh T, Sakanaka M, Katayama T, Jin C, Karlsson NG, Arumugam M, Fushinobu S, Abou Hachem M.	Nat Commun	10.1038/s41467-020-17075-x	2020
	Cross-generational bacterial strain transfer to an infant after fecal microbiota transplantation to a pregnant patient: a case report.	Wei S, Jespersen ML, Baunwall SMD, Myers PN, Smith EM, Dahlerup JF, Rasmussen S, Nielsen HB, Licht TR, Bahl MI, Hvas CL.	Microbiome	10.1186/s40168-022-01394-w	2022
	Perturbed Microbiota/Immune Homeostasis in Multiple Sclerosis.	Sterlin D, Larsen M, Fadlallah J, Parizot C, Vignes M, Autaa G, Dorgham K, Juste C, Lepage P, Aboab J, Vicart S, Maillart E, Gout O, Lubetzki C, Deschamps R, Papeix C, Gorochov G.	Neurol Neuroimmunol Neuroinflamm	10.1212/nxi.0000000000000997	2021
Metabolism	SIMMER employs similarity algorithms to accurately identify human gut microbiome species and enzymes capable of known chemical transformations.	Bustion AE, Nayak RR, Agrawal A, Turnbaugh PJ, Pollard KS.	Elife	10.7554/elife.82401	2023
Metabolism	Differential effects of coconut versus soy oil on gut microbiota composition and predicted metabolic function in adult mice.	Patrone V, Minuti A, Lizier M, Miragoli F, Lucchini F, Trevisi E, Rossi F, Callegari ML.	BMC Genomics	10.1186/s12864-018-5202-z	2018
	Development of an in vitro Model of Human Gut Microbiota for Screening the Reciprocal Interactions With Antibiotics, Drugs, and Xenobiotics.	El Houari A, Ecale F, Mercier A, Crapart S, Laparre J, Soulard B, Ramnath M, Berjeaud JM, Rodier MH, Crepin A.	Front Microbiol	10.3389/fmicb.2022.828359	2022
	Commensal Obligate Anaerobic Bacteria and Health: Production, Storage, and Delivery Strategies.	Andrade JC, Almeida D, Domingos M, Seabra CL, Machado D, Freitas AC, Gomes AM.	Front Bioeng Biotechnol	10.3389/fbioe.2020.00550	2020
Metabolism	Rational design of a microbial consortium of mucosal sugar utilizers reduces Clostridiodes difficile colonization.	Pereira FC, Wasmund K, Cobankovic I, Jehmlich N, Herbold CW, Lee KS, Lee KS, Sziranyi B, Vesely C, Decker T, Stocker R, Warth B, von Bergen M, Wagner M, Berry D.	Nat Commun	10.1038/s41467-020-18928-1	2020
Metabolism	Paneth Cell-Derived Lysozyme Defines the Composition of Mucolytic Microbiota and the Inflammatory Tone of the Intestine.	Yu S, Balasubramanian I, Laubitz D, Tong K, Bandyopadhyay S, Lin X, Flores J, Singh R, Liu Y, Macazana C, Zhao Y, Beguet-Crespel F, Patil K, Midura-Kiela MT, Wang D, Yap GS, Ferraris RP, Wei Z, Bonder EM, Haggblom MM, Zhang L, Douard V, Verzi MP, Cadwell K, Kiela PR, Gao N.	Immunity	10.1016/j.immuni.2020.07.010	2020
	Bifidobacteria support optimal infant vaccine responses.	Ryan FJ, Clarke M, Lynn MA, Benson SC, McAlister S, Giles LC, Choo JM, Rossouw C, Ng YY, Semchenko EA, Richard A, Leong LEX, Taylor SL, Blake SJ, Mugabushaka JI, Walker M, Wesselingh SL, Licciardi PV, Seib KL, Tumes DJ, Richmond P, Rogers GB, Marshall HS, Lynn DJ.	Nature	10.1038/s41586-025-08796-4	2025
Enzymology	Sialidases from gut bacteria: a mini-review.	Juge N, Tailford L, Owen CD.	Biochem Soc Trans	10.1042/bst20150226	2016
Enzymology	Degradation of the low-calorie sugar substitute 5-ketofructose by different bacteria.	Schiessl J, Kosciow K, Garschagen LS, Hoffmann JJ, Heymuth J, Franke T, Deppenmeier U.	Appl Microbiol Biotechnol	10.1007/s00253-021-11168-3	2021
	Developing standards for the microbiome field.	Amos GCA, Logan A, Anwar S, Fritzsche M, Mate R, Bleazard T, Rijpkema S.	Microbiome	10.1186/s40168-020-00856-3	2020
	Selection of cross-reactive T cells by commensal and food-derived yeasts drives cytotoxic T_H1 cell responses in Crohn's disease.	Martini GR, Tikhonova E, Rosati E, DeCelie MB, Sievers LK, Tran F, Lessing M, Bergfeld A, Hinz S, Nikolaus S, Kumpers J, Matysiak A, Hofmann P, Saggau C, Schneiders S, Kamps AK, Jacobs G, Lieb W, Maul J, Siegmund B, Seegers B, Hinrichsen H, Oberg HH, Wesch D, Bereswill S, Heimesaat MM, Rupp J, Kniemeyer O, Brakhage AA, Brunke S, Hube B, Aden K, Franke A, Iliev ID, Scheffold A, Schreiber S, Bacher P.	Nat Med	10.1038/s41591-023-02556-5	2023
Phylogeny	Cooking shapes the structure and function of the gut microbiome.	Carmody RN, Bisanz JE, Bowen BP, Maurice CF, Lyalina S, Louie KB, Treen D, Chadaideh KS, Maini Rekdal V, Bess EN, Spanogiannopoulos P, Ang QY, Bauer KC, Balon TW, Pollard KS, Northen TR, Turnbaugh PJ.	Nat Microbiol	10.1038/s41564-019-0569-4	2019
Metabolism	Phylogenetic distribution of three pathways for propionate production within the human gut microbiota.	Reichardt N, Duncan SH, Young P, Belenguer A, McWilliam Leitch C, Scott KP, Flint HJ, Louis P.	ISME J	10.1038/ismej.2014.14	2014
Pathogenicity	The Use of Defined Microbial Communities To Model Host-Microbe Interactions in the Human Gut.	Elzinga J, van der Oost J, de Vos WM, Smidt H.	Microbiol Mol Biol Rev	10.1128/mmbr.00054-18	2019
Metabolism	Methotrexate impacts conserved pathways in diverse human gut bacteria leading to decreased host immune activation.	Nayak RR, Alexander M, Deshpande I, Stapleton-Gray K, Rimal B, Patterson AD, Ubeda C, Scher JU, Turnbaugh PJ.	Cell Host Microbe	10.1016/j.chom.2020.12.008	2021
	Therapeutic potential of Akkermansia muciniphila in non-alcoholic fatty liver disease: a systematic review.	Asghari P, Ahmadi-Khorram M, Hatami A, Talebi S, Afshari A.	BMC Gastroenterol	10.1186/s12876-025-04436-3	2025
	Safety of an extension of use of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283.	EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Camara M, Castenmiller J, De Henauw S, Jos A, Maciuk A, Mangelsdorf I, McNulty B, Naska A, Pentieva K, Siani A, Thies F, Aguilera-Gomez M, Frenzel T, Marcon F, McArdle HJ, Moldeus P, Neuhauser-Berthold M, Poulsen M, Prieto Maradona M, Schlatter JR, van Loveren H, Ackerl R, Hirsch-Ernst KI.	EFSA J	10.2903/j.efsa.2025.9632	2025
Transcriptome	Effects of Akkermansia muciniphila on growth, antioxidant status and jejunal transcriptome in LPS-stressed yellow-feathered broilers.	Zhu R, Jing Y, Tang J, Ou L, Zou Z, Luo C, Qi Q, Feng X.	Poult Sci	10.1016/j.psj.2025.105954	2025
	Advancements in understanding the relationship between Akkermansia muciniphila and the development of ulcerative colitis.	Xu N, Xiao X, Ma Y, Jing J, Jiang S, Luo K, Li Y, Duan M.	Front Pediatr	10.3389/fped.2025.1673156	2025
Metabolism	Investigating the role of Akkermansia muciniphila Akk11 in modulating obesity and intestinal dysbiosis: a comparative study of live and pasteurized treatments.	Feng S, Wang W, Zhang X, Helal SE, Peng N, Zhang Z.	Front Microbiol	10.3389/fmicb.2025.1638771	2025
	Membrane vesicles produced by next-generation probiotics from the gut as innovative tools for human health.	Abraham L, Raise A, Beney L, Lapaquette P, Rieu A.	Gut Microbes	10.1080/19490976.2025.2552344	2025
	Akkermansia muciniphila-derived hypoacylated rough-type lipopolysaccharides alleviate diet-induced obesity via activation of TLR4-IL-23-IL-22 immune axis.	Sun L, Zhang Y, Dong W, Sun J, Wang T, Shao F, Dai H, Han J, Wang W, Wang S, Zhao T, Wang L, Liu C, Liu S, Liu H.	Imeta	10.1002/imt2.70066	2025
	Live Akkermansia muciniphila boosts dendritic cell retinoic acid synthesis to modulate IL-22 activity and mitigate colitis in mice.	Liu H, Huang R, Shen B, Huang C, Zhou Q, Xu J, Chen S, Lin X, Wang J, Zhao X, Guo Y, Ai X, Liu Y, Wang Y, Zhang W, Zhi F.	Microbiome	10.1186/s40168-024-01995-7	2024
	The pathobiont role of Akkermansia muciniphila in colorectal cancer: a systematic review.	Soheilipour M, Noursina A, Nekookhoo M, Malekpour E, Mirzaei SA, Shafieyoun MH, Rouzbahani H, Chitsazi MR, Safari F.	BMC Gastroenterol	10.1186/s12876-025-04293-0	2025
Pathogenicity	The biofunction of Akkermansia muciniphila in intestinal-related diseases.	Jiang P, Ji S, Su D, Zhao Y, Goncalves VBE, Xu G, Zhang M.	Microbiome Res Rep	10.20517/mrr.2024.12	2024
	Akkermansia muciniphila: a microbial guardian against oxidative stress-gut microbiota crosstalk and clinical prospects.	Ye WY, Cai Y.	J Transl Med	10.1186/s12967-025-07149-z	2025
	The role of Akkermansia muciniphila in maintaining health: a bibliometric study.	Gao F, Cheng C, Li R, Chen Z, Tang K, Du G.	Front Med (Lausanne)	10.3389/fmed.2025.1484656	2025
	Akkermansia muciniphila ameliorates chronic stress-induced colorectal tumor growth by releasing outer membrane vesicles.	Jin S, Lu Y, Zuo Y, Xu Q, Hao Y, Zuo H, Cui Z, Zhang X, Wang M, Li H, Wang S, Li Y.	Gut Microbes	10.1080/19490976.2025.2555618	2025
Pathogenicity	Akkermansia muciniphila alleviates cognitive impairment and neuroinflammation induced by blunt chest trauma.	Liu L, Wang L, Wang Y, Zhao H, Gao X, Yin W, Xie J.	Front Immunol	10.3389/fimmu.2025.1657524	2025
	Pasteurized Akkermansia muciniphila Timepie001 ameliorates DSS-induced ulcerative colitis in mice by alleviating intestinal injury and modulating gut microbiota.	Han H, Xiong H, Liu Z, Liu X, Wang H, Kou J, Yi D, Shi Y, Wu H, Qiao J.	Front Microbiol	10.3389/fmicb.2025.1542522	2025
	Enhancing immunotherapy efficacy in NSCLC through the combined use of phenelzine and Akkermansia muciniphila to regulate gut microbial metabolite 5-HIAA.	Sun S, Wang L, Cui K, Ding Y, Wei Y, Zheng Y, Shen Z, Zhu L, Yang Y, Yu P, Song Y, Chao K, Zhang Y, Ge Y, Ji W, Li C, Sethi G, Li L, Zhao J.	J Immunother Cancer	10.1136/jitc-2025-011831	2025
Metabolism	The Positive Effect of Akkermansia muciniphila postbiotics on the Glycolipid Metabolism of Caenorhabditis elegans Induced by High-Glucose Diet.	Wu Z, Li K, Hou A, Wang Y, Li Z.	Nutrients	10.3390/nu17060976	2025
Genetics	Genomic Face-off: An In Silico Comparison of the Probiotic Potential of Lactobacillus spp. and Akkermansia muciniphila.	Fakruddin M, Abu Bakar Karim M, Islam BU, Safa A, Sultana J, Bulbul N, Shishir MA.	Curr Genomics	10.2174/0113892029317403240815044408	2025
Genetics	Deep sequencing-derived Metagenome Assembled Genomes from the gut microbiome of liver transplant patients.	Banerjee G, Papri SR, Huang H, Satapathy SK, Banerjee P.	Sci Data	10.1038/s41597-024-04153-8	2025
	Antibiotic-associated changes in Akkermansia muciniphila alter its effects on host metabolic health.	Han Y, Teng TM, Han J, Kim HS.	Microbiome	10.1186/s40168-024-02023-4	2025
	Heterocyclic Antidepressants with Antimicrobial and Fungicide Activity.	Zolotareva D, Zazybin A, Belyankova Y, Bayazit S, Dauletbakov A, Seilkhanov T, Kemelbekov U, Aydemir M.	Molecules	10.3390/molecules30051102	2025
	Big lessons from the little Akkermansia muciniphila in hepatocellular carcinoma.	Yang Y, Shi X.	Front Immunol	10.3389/fimmu.2025.1524563	2025
	Comprehensive profiling of genomic invertons in defined gut microbial community reveals associations with intestinal colonization and surface adhesion.	Jin X, Cheng AG, Chanin RB, Yu FB, Dimas A, Jasper M, Weakley A, Yan J, Bhatt AS, Pollard KS.	Microbiome	10.1186/s40168-025-02052-7	2025
	Pasteurized Akkermansia muciniphila Ameliorates Preeclampsia in Mice by Enhancing Gut Barrier Integrity, Improving Endothelial Function, and Modulating Gut Metabolic Dysregulation.	Peng L, Yin Q, Wang X, Zhong Y, Wang Y, Cai W, Zhou R, Chen Y, Hu Y, Cheng Z, Jiang W, Yue X, Huang L.	Microorganisms	10.3390/microorganisms12122483	2024
	Akkermansia muciniphila in the small intestine improves liver fibrosis in a murine liver cirrhosis model.	Oguri N, Miyoshi J, Nishinarita Y, Wada H, Nemoto N, Hibi N, Kawamura N, Miyoshi S, Lee STM, Matsuura M, Osaki T, Hisamatsu T.	NPJ Biofilms Microbiomes	10.1038/s41522-024-00564-y	2024
	Akkermansia muciniphila-Derived N-Acetylspermidine Modulates the Localization of Intestinal alpha1,2-Fucosylated Proteins to Maintain Gut Homeostasis.	Yao Y, Pei Z, Dai Y, Chen Y, Chang Z, Wang H, Zhao J, Zhang H, Zhai Q, Lu W, Chen W.	Adv Sci (Weinh)	10.1002/advs.202506576	2025
	Carbohydrate-active enzymes from Akkermansia muciniphila break down mucin O-glycans to completion.	Bakshani CR, Ojuri TO, Pilgaard B, Holck J, McInnes R, Kozak RP, Zakhour M, Cakaj S, Kerouedan M, Newton E, Bolam DN, Crouch LI.	Nat Microbiol	10.1038/s41564-024-01911-7	2025
	Rehydration Beverages Made from Quercus sideroxyla Infusion, Probiotics, and Prebiotics: Antioxidant and Anti-Inflammatory Potential.	Salas-Ramirez CA, Moreno-Jimenez MR, Rocha-Guzman NE, Gallegos-Infante JA, Gonzalez-Laredo RF, Gonzalez Herrera SM, Gonzalez-Mercado ME, Herrera-Rocha KM, Chairez-Ramirez MH.	Foods	10.3390/foods14050837	2025
	Akkermansia muciniphila and its metabolite propionic acid maintains neuronal mitochondrial division and autophagy homeostasis during Alzheimer's disease pathologic process via GPR41 and GPR43.	Wang Z, Wang C, Yuan B, Liu L, Zhang H, Zhu M, Chai H, Peng J, Huang Y, Zhou S, Liu J, Wu L, Wang W.	Microbiome	10.1186/s40168-024-02001-w	2025
	Akkermansia muciniphila Muc^T harnesses dietary polyphenols as xenosiderophores for enhanced iron uptake.	Rodriguez-Daza MC, Boeren S, Tytgat HLP, Desjardins Y, de Vos WM.	Nat Commun	10.1038/s41467-025-64477-w	2025
	Allobaculum mucilyticum-Mediated Gut Barrier Dysfunction Exacerbates the Severity of Hypertriglyceridemic Acute Pancreatitis in Mice.	Yang P, Wu M, Liang W, Sun Y, Pan LL, Sun J.	Antioxidants (Basel)	10.3390/antiox14111284	2025
	Integrated metabolomics and the microbiome reveal the compatibility mechanism of the Suxiao Jiuxin pill in the treatment of stable coronary artery disease.	Le W, Liao J, Zhang Y, Xu J, Zeng Y, Li H, Shen X, Wu G, Zhang W.	Chin Med	10.1186/s13020-025-01198-8	2025
	Characterization and Anti-Inflammatory Effects of Akkermansia muciniphila-Derived Extracellular Vesicles.	Zhao S, Xiang J, Abedin M, Wang J, Zhang Z, Zhang Z, Wu H, Xiao J.	Microorganisms	10.3390/microorganisms13020464	2025
Genetics	O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases.	Labourel A, Parrou JL, Deraison C, Mercier-Bonin M, Lajus S, Potocki-Veronese G.	Essays Biochem	10.1042/ebc20220153	2023
	Akkermansia mono-colonization modulates microglia and astrocytes in a strain specific manner.	Schwerdtfeger LA, Lanser TB, Montini F, Moreira T, LeServe DS, Cox LM, Weiner HL.	J Neuroinflammation	10.1186/s12974-025-03417-3	2025
	Dietary Selenium Deficiency Accelerates the Onset of Aging-Related Gut Microbial Changes in Aged Telomere-Humanized Mice, With Akkermansia muciniphila Being the Most Prominent and Alleviating Selenium Deficiency-Induced Type 2 Diabetes.	Huang YC, Lu HY, Zhang L, Olivier A, Wu TL, Hsu CY, LeGrand C, Zeng H, Curran S, Wang Q, Nannapaneni R, Zhang X, Tico M, Mariotti M, Wu RTY, Combs GF, Cheng WH.	Aging Cell	10.1111/acel.70130	2025
	The Effect of Photobiomodulation and Akkermansia muciniphila on THP-1 Derived Macrophage Polarization Treated with Gliadin Peptide.	Jahani-Sherafat S, Mollaghaei S, Asri N, Rezaei Tavirani M, Baghaei K, Rostami-Nejad M.	J Lasers Med Sci	10.34172/jlms.2024.21	2024
	Akkermansia muciniphila Metabolite Inosine Inhibits Castration Resistance in Prostate Cancer.	Yu Y, Li L, Yang Q, Xue J, Wang B, Xie M, Shangguan W, Zhu Z, Wu P.	Microorganisms	10.3390/microorganisms12081653	2024
	Oral Combined Probiotics Clostridium butyricum and Akkermansia muciniphila Inhibits the Progression of 4T1 Breast Cancer by Activating Bcl-2/Bax Pathway.	Li X, Hua D, Wu D, Hong W, Kang Y, Tang L, Yang Q, Wang X, Li B, Li R, Chen Z, Cui G.	Cancer Med	10.1002/cam4.70987	2025
Phylogeny	Optimizing Akkermansia muciniphila Isolation and Cultivation: Insights into Gut Microbiota Composition and Potential Growth Promoters in a Chinese Cohort.	Meng X, Xv C, Lv J, Zhang S, Ma C, Pang X.	Microorganisms	10.3390/microorganisms12050881	2024
Biotechnology	Omics-based analysis of Akkermansia muciniphila cultivation in food-grade media.	Geerlings SY, van der Ark K, Nijsse B, Boeren S, van Loosdrecht M, Belzer C, de Vos WM.	Microbiome Res Rep	10.20517/mrr.2024.06	2024
	Postbiotics: a perspective on their quantification.	Vinderola G, Benkowski A, Bernardeau M, Chenoll E, Collado MC, Cronin U, Eckhardt E, Green JB, Ipharraguerre IR, Kemperman R, Lacroix C, Minami J, Wilkinson M, Sanders ME, Salminen S.	Front Nutr	10.3389/fnut.2025.1582733	2025
	Gut-derived lactic acid enhances tryptophan to 5-hydroxytryptamine in regulation of anxiety via Akkermansia muciniphila.	Pan M, Qian C, Huo S, Wu Y, Zhao X, Ying Y, Wang B, Yang H, Yeerken A, Wang T, Fu M, Wang L, Wei Y, Zhao Y, Shao C, Wang H, Zhao C.	Gut Microbes	10.1080/19490976.2024.2447834	2025
	Peptidoglycan from Akkermansia muciniphila MucT: chemical structure and immunostimulatory properties of muropeptides.	Garcia-Vello P, Tytgat HLP, Gray J, Elzinga J, Di Lorenzo F, Biboy J, Vollmer D, De Castro C, Vollmer W, de Vos WM, Molinaro A.	Glycobiology	10.1093/glycob/cwac027	2022
	[Akkermansia muciniphila gavage improves gut-brain interaction disorders in gp120 transgenic mice].	Luo J, Batzaya S, Gao X, Chen J, Yu Z, Xiong S, Cao H.	Nan Fang Yi Ke Da Xue Xue Bao	10.12122/j.issn.1673-4254.2025.03.13	2025
	Emerging Roles of the Gut Microbiome in Musculoskeletal Injury and Repair.	Roberts JL, Park CC.	Microorganisms	10.3390/microorganisms13092193	2025
	Function of Akkermansia muciniphila in type 2 diabetes and related diseases.	Li J, Yang G, Zhang Q, Liu Z, Jiang X, Xin Y.	Front Microbiol	10.3389/fmicb.2023.1172400	2023
	Carbon dioxide enhances Akkermansia muciniphila fitness and anti-obesity efficacy in high-fat diet mice.	Wang X, Yang Q, Shi C, Wang Y, Guo D, Wan X, Dong P, Zhang Q, Hu Y, Zhang R, Yang H, Chen W, Liu Z.	ISME J	10.1093/ismejo/wraf034	2025
Pathogenicity	The Role of Akkermansia muciniphila on Improving Gut and Metabolic Health Modulation: A Meta-Analysis of Preclinical Mouse Model Studies.	Khalili L, Park G, Nagpal R, Salazar G.	Microorganisms	10.3390/microorganisms12081627	2024
Pathogenicity	Akkermansia muciniphila - friend or foe in colorectal cancer?	Gubernatorova EO, Gorshkova EA, Bondareva MA, Podosokorskaya OA, Sheynova AD, Yakovleva AS, Bonch-Osmolovskaya EA, Nedospasov SA, Kruglov AA, Drutskaya MS.	Front Immunol	10.3389/fimmu.2023.1303795	2023
Genetics	Akkermansia muciniphila Exerts Strain-Specific Effects on DSS-Induced Ulcerative Colitis in Mice.	Liu Q, Lu W, Tian F, Zhao J, Zhang H, Hong K, Yu L.	Front Cell Infect Microbiol	10.3389/fcimb.2021.698914	2021
	Structural and functional insights into metal coordination and substrate recognition of Akkermansia muciniphila sialidase Amuc_1547.	Li T, Tang X, Zhu Y, Zhao N, Song Y, He L, Mou X, Ge C, Chen Z, Zhang H, Yao X, Hu X, Cheng J, Yao H, Bao R.	Mol Biomed	10.1186/s43556-025-00265-8	2025
Proteome	Nutrient-specific proteomic analysis of the mucin degrading bacterium Akkermansia muciniphila.	Lee JY, Jin HS, Kim KS, Baek JH, Kim BS, Lee DW.	Proteomics	10.1002/pmic.202100125	2022
	Synthetic microbial community improves chicken intestinal homeostasis and provokes anti-Salmonella immunity mediated by segmented filamentous bacteria.	Zhang M, Shi S, Feng Y, Zhang F, Xiao Y, Li X, Pan X, Feng Y, Liu D, Guo Y, Hu Y.	ISME J	10.1093/ismejo/wraf076	2025
Pathogenicity	Akkermansia muciniphila exacerbates acute radiation-induced intestinal injury by depleting mucin and enhancing inflammation.	Wang Y, Wang X, Chen Z, Zheng J, Liu X, Zheng Y, Zheng Z, Xu Z, Zhang Y, Chen K, Zhang Y, Yu L, Ding Y.	ISME J	10.1093/ismejo/wraf084	2025
	Community metabolic modeling of host-microbiota interactions through multi-objective optimization.	Lambert A, Budinich M, Mahe M, Chaffron S, Eveillard D.	iScience	10.1016/j.isci.2024.110092	2024
Pathogenicity	Akkermansia muciniphila-induced trained immune phenotype increases bacterial intracellular survival and attenuates inflammation.	Pena-Cearra A, Palacios A, Pellon A, Castelo J, Pasco ST, Seoane I, Barriales D, Martin JE, Pascual-Itoiz MA, Gonzalez-Lopez M, Martin-Ruiz I, Macias-Camara N, Gutiez N, Araujo-Aris S, Aransay AM, Rodriguez H, Anguita J, Abecia L.	Commun Biol	10.1038/s42003-024-05867-6	2024
	Health Effects and Therapeutic Potential of the Gut Microbe Akkermansia muciniphila.	Aja E, Zeng A, Gray W, Connelley K, Chaganti A, Jacobs JP.	Nutrients	10.3390/nu17030562	2025
	Akkermansia muciniphila supplementation improves glucose tolerance in intestinal Ffar4 knockout mice during the daily light to dark transition.	Wang Z, Cui S, Zhang T, Wang W, Li J, Chen YQ, Zhu Sl.	mSystems	10.1128/msystems.00573-23	2023
	Akkermansia muciniphila induces slow extramedullary hematopoiesis via cooperative IL-1R/TLR signals.	Wang Y, Morishima T, Sezaki M, Sato R, Nakato G, Fukuda S, Kobiyama K, Ishii KJ, Li Y, Takizawa H.	EMBO Rep	10.15252/embr.202357485	2023
Metabolism	Substrate specificity of the galactokinase from the human gut symbiont Akkermansia muciniphila ATCC BAA-835.	Zhang X, Sheng W, Li K, Rong Y, Wu Q, Meng Q, Kong Y, Chen M.	Enzyme Microb Technol	10.1016/j.enzmictec.2020.109568	2020
	Potential Effects of Akkermansia Muciniphila in Aging and Aging-Related Diseases: Current Evidence and Perspectives.	Zeng SY, Liu YF, Liu JH, Zeng ZL, Xie H, Liu JH.	Aging Dis	10.14336/ad.2023.0325	2023
	The evolution and competitive strategies of Akkermansia muciniphila in gut.	Kim JS, Kang SW, Lee JH, Park SH, Lee JS.	Gut Microbes	10.1080/19490976.2021.2025017	2022
	Akkermansia muciniphila alleviates high-fat-diet-related metabolic-associated fatty liver disease by modulating gut microbiota and bile acids.	Wu W, Kaicen W, Bian X, Yang L, Ding S, Li Y, Li S, Zhuge A, Li L.	Microb Biotechnol	10.1111/1751-7915.14293	2023
	Akkermansia muciniphila-derived acetate activates the hepatic AMPK/SIRT1/PGC-1alpha axis to alleviate ferroptosis in metabolic-associated fatty liver disease.	Zhuge A, Li S, Han S, Yuan Y, Shen J, Wu W, Wang K, Xia J, Wang Q, Gu Y, Chen E, Li L.	Acta Pharm Sin B	10.1016/j.apsb.2024.10.010	2025
	The combination of Clostridium butyricum and Akkermansia muciniphila mitigates DSS-induced colitis and attenuates colitis-associated tumorigenesis by modulating gut microbiota and reducing CD8⁺ T cells in mice.	Hua D, Yang Q, Li X, Zhou X, Kang Y, Zhao Y, Wu D, Zhang Z, Li B, Wang X, Qi X, Chen Z, Cui G, Hong W.	mSystems	10.1128/msystems.01567-24	2025
Pathogenicity	Development of the Gut Microbial Immune and Epithelial Cellular System (GutMICS) to Investigate the Immunological Role of Gut Anaerobes.	Kwon SY, Jo SH, Park J, Park JH, Kim YR, Baek JH, Kim MG, Choi BG, Hong NY, Jung HK, Ryu HW, Jeon JS, Kim YG.	Biotechnol Bioeng	10.1002/bit.29031	2025
Metabolism	Citrus Pectin Supplementation Alleviated Hepatic Lipid Accumulation through Gut Microbiota Indole Lactic Acid Promoting Hepatic Bile Acid Synthesis and Excretion.	Pan Z, Jin X, Li Q, Zhou Y, Zeng Y, Wang X, Jin Y, Chen Y, Li D, Ling W.	Int J Biol Sci	10.7150/ijbs.116929	2025
	Akkermansia muciniphila isolated from forest musk deer ameliorates diarrhea in mice via modification of gut microbiota.	Deng Y, Wang Y, Liu Y, Yang X, Zhang H, Xue X, Wan Y.	Animal Model Exp Med	10.1002/ame2.12441	2025
	Akkermansia muciniphila supplementation prevents cognitive impairment in sleep-deprived mice by modulating microglial engulfment of synapses.	Li N, Tan S, Wang Y, Deng J, Wang N, Zhu S, Tian W, Xu J, Wang Q.	Gut Microbes	10.1080/19490976.2023.2252764	2023
Metabolism	Gut Microbiota Dysbiosis and Its Impact on Type 2 Diabetes: From Pathogenesis to Therapeutic Strategies.	Yu Y, Ding Y, Wang S, Jiang L.	Metabolites	10.3390/metabo15060397	2025
Pathogenicity	Akkermansia muciniphila participates in the host protection against helminth-induced cardiac fibrosis via TLR2.	Wang J, Liu X, Sun R, Mao H, Liu M, Jin X.	PLoS Pathog	10.1371/journal.ppat.1011683	2023
Pathogenicity	Akkermansia muciniphila Is Beneficial to a Mouse Model of Parkinson's Disease, via Alleviated Neuroinflammation and Promoted Neurogenesis, with Involvement of SCFAs.	Qiao CM, Huang WY, Zhou Y, Quan W, Niu GY, Li T, Zhang MX, Wu J, Zhao LP, Zhao WJ, Cui C, Shen YQ.	Brain Sci	10.3390/brainsci14030238	2024
	Influence of Symbiotic Fermentation Broth on Regulating Metabolism with Gut Microbiota and Metabolite Profiles Is Estimated Using a Third-Generation Sequencing Platform.	Wu CY, Huang CK, Hong WS, Liu YH, Shih MC, Lin JC.	Metabolites	10.3390/metabo13090999	2023
	The Role of the Gut Microbiome and Microbial Dysbiosis in Common Skin Diseases.	Rygula I, Pikiewicz W, Grabarek BO, Wojcik M, Kaminiow K.	Int J Mol Sci	10.3390/ijms25041984	2024
	Akkermansia muciniphila Ameliorates Alcoholic Liver Disease in Experimental Mice by Regulating Serum Metabolism and Improving Gut Dysbiosis.	Fang C, Cheng J, Jia W, Xu Y.	Metabolites	10.3390/metabo13101057	2023
	Akkermansia muciniphila identified as key strain to alleviate gut barrier injury through Wnt signaling pathway.	Ma X, Li M, Zhang Y, Xu T, Zhou X, Qian M, Yang Z, Han X.	Elife	10.7554/elife.92906	2025
Proteome	Revealing Glycosylation Patterns in In Vitro-Produced Mucus Exposed to Pasteurized Mucus-Associated Intestinal Microbes by MALDI-TOF-MS and PGC-LC-MS/MS.	de Ram C, van der Lugt B, Elzinga J, Geerlings S, Steegenga WT, Belzer C, Schols HA.	J Agric Food Chem	10.1021/acs.jafc.4c01401	2024
	Akkermansia muciniphila suppressing nonalcoholic steatohepatitis associated tumorigenesis through CXCR6⁺ natural killer T cells.	Li T, Lin X, Shen B, Zhang W, Liu Y, Liu H, Wang Y, Zheng L, Zhi F.	Front Immunol	10.3389/fimmu.2022.1047570	2022
	Effect of Extracelluar Vesicles Derived from Akkermansia muciniphila on Intestinal Barrier in Colitis Mice.	Zheng T, Hao H, Liu Q, Li J, Yao Y, Liu Y, Zhang T, Zhang Z, Yi H.	Nutrients	10.3390/nu15224722	2023
	Characterizing the mucin-degrading capacity of the human gut microbiota.	Glover JS, Ticer TD, Engevik MA.	Sci Rep	10.1038/s41598-022-11819-z	2022
Pathogenicity	Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance.	Wang Y, Li C, Li J, Zhang S, Zhang Q, Duan J, Guo J.	Acta Pharm Sin B	10.1016/j.apsb.2024.06.002	2024
	Dietary palmitoleic acid reprograms gut microbiota and improves biological therapy against colitis.	Chen Y, Mai Q, Chen Z, Lin T, Cai Y, Han J, Wang Y, Zhang M, Tan S, Wu Z, Chen L, Zhang Z, Yang Y, Cui T, Ouyang B, Sun Y, Yang L, Xu L, Zhang S, Li J, Shen H, Liu L, Zeng L, Zhang S, Zeng G.	Gut Microbes	10.1080/19490976.2023.2211501	2023
	Potential of Akkermansia muciniphila and its outer membrane proteins as therapeutic targets for neuropsychological diseases.	Zhang F, Wang D.	Front Microbiol	10.3389/fmicb.2023.1191445	2023
	Novel Candidate Microorganisms for Fermentation Technology: From Potential Benefits to Safety Issues.	Agagunduz D, Yilmaz B, Kocak T, Altintas Basar HB, Rocha JM, Ozogul F.	Foods	10.3390/foods11193074	2022
Pathogenicity	The influence of Akkermansia muciniphila on intestinal barrier function.	Mo C, Lou X, Xue J, Shi Z, Zhao Y, Wang F, Chen G.	Gut Pathog	10.1186/s13099-024-00635-7	2024
Genetics	Comparative Genomics and Pan-Genome Driven Prediction of a Reduced Genome of Akkermansia muciniphila.	Bukhari SAR, Irfan M, Ahmad I, Chen L.	Microorganisms	10.3390/microorganisms10071350	2022
	Improvement in Zebrafish with Diabetes and Alzheimer's Disease Treated with Pasteurized Akkermansia muciniphila.	Qu L, Liu F, Fang Y, Wang L, Chen H, Yang Q, Dong H, Jin L, Wu W, Sun D.	Microbiol Spectr	10.1128/spectrum.00849-23	2023
Metabolism	Akkermansia muciniphila Cell-Free Supernatant Improves Glucose and Lipid Metabolisms in Caenorhabditis elegans.	Wu ZQ, Chen XM, Ma HQ, Li K, Wang YL, Li ZJ.	Nutrients	10.3390/nu15071725	2023
Pathogenicity	Akkermansia muciniphila: A promising probiotic against inflammation and metabolic disorders.	Zhao Y, Yang H, Wu P, Yang S, Xue W, Xu B, Zhang S, Tang B, Xu D.	Virulence	10.1080/21505594.2024.2375555	2024
	Identification and Characterization of a Novel Species of Genus Akkermansia with Metabolic Health Effects in a Diet-Induced Obesity Mouse Model.	Kumar R, Kane H, Wang Q, Hibberd A, Jensen HM, Kim HS, Bak SY, Auzanneau I, Bry S, Christensen N, Friedman A, Rasinkangas P, Ouwehand AC, Forssten SD, Hasselwander O.	Cells	10.3390/cells11132084	2022
Metabolism	The Intestinal Effect of Atorvastatin: Akkermansia muciniphila and Barrier Function.	Cheng T, Li C, Shen L, Wang S, Li X, Fu C, Li T, Liu B, Gu Y, Wang W, Feng B.	Front Microbiol	10.3389/fmicb.2021.797062	2021
	The role of Akkermansia muciniphila in inflammatory bowel disease: Current knowledge and perspectives.	Zheng M, Han R, Yuan Y, Xing Y, Zhang W, Sun Z, Liu Y, Li J, Mao T.	Front Immunol	10.3389/fimmu.2022.1089600	2022
	Membrane Protein Amuc_1100 Derived from Akkermansia muciniphila Facilitates Lipolysis and Browning via Activating the AC3/PKA/HSL Pathway.	Zheng X, Huang W, Li Q, Chen Y, Wu L, Dong Y, Huang X, He X, Ou Z, Peng Y.	Microbiol Spectr	10.1128/spectrum.04323-22	2023
Pathogenicity	The lipooligosaccharide of the gut symbiont Akkermansia muciniphila exhibits a remarkable structure and TLR signaling capacity.	Garcia-Vello P, Tytgat HLP, Elzinga J, Van Hul M, Plovier H, Tiemblo-Martin M, Cani PD, Nicolardi S, Fragai M, De Castro C, Di Lorenzo F, Silipo A, Molinaro A, de Vos WM.	Nat Commun	10.1038/s41467-024-52683-x	2024
	Binding of Akkermansia muciniphila to mucin is O-glycan specific.	Elzinga J, Narimatsu Y, de Haan N, Clausen H, de Vos WM, Tytgat HLP.	Nat Commun	10.1038/s41467-024-48770-8	2024
	Analysis of Akkermansia muciniphila in Mulberry Galacto-Oligosaccharide Medium via Comparative Transcriptomics.	Li E, Li S, Liu F, Li Q, Pang D, Wang H, Liao S, Zou Y.	Foods	10.3390/foods12030440	2023
	Akkermansia muciniphila and Lactobacillus plantarum ameliorate systemic lupus erythematosus by possibly regulating immune response and remodeling gut microbiota.	Guo M, Lu M, Chen K, Xu R, Xia Y, Liu X, Liu Z, Liu Q.	mSphere	10.1128/msphere.00070-23	2023
	Quantitative real-time PCR analysis of bacterial biomarkers enable fast and accurate monitoring in inflammatory bowel disease.	Sezgin E, Terlemez G, Bozkurt B, Bengi G, Akpinar H, Buyuktorun I.	PeerJ	10.7717/peerj.14217	2022
	Akkermansia muciniphila exerts immunomodulatory and anti-inflammatory effects on gliadin-stimulated THP-1 derived macrophages.	Molaaghaee-Rouzbahani S, Asri N, Sapone A, Baghaei K, Yadegar A, Amani D, Rostami-Nejad M.	Sci Rep	10.1038/s41598-023-30266-y	2023
	Extracellular vesicles hybrid plasmid-loaded lipid nanovesicles for synergistic cancer immunotherapy.	Tong Q, Li K, Huang F, Dai Y, Zhang T, Muaibati M, Abuduyilimu A, Huang X.	Mater Today Bio	10.1016/j.mtbio.2023.100845	2023
Enzymology	Division of the large and multifunctional glycoside hydrolase family 2: high functional specificity and biochemical assays in the uncharacterized subfamilies.	Lebreton A, Garron ML, Vuillemin M, Pilgaard B, Hornung BVH, Drula E, Lombard V, Helbert W, Henrissat B, Terrapon N.	Biotechnol Biofuels Bioprod	10.1186/s13068-025-02669-8	2025
	Characterization of three novel beta-galactosidases from Akkermansia muciniphila involved in mucin degradation.	Kosciow K, Deppenmeier U.	Int J Biol Macromol	10.1016/j.ijbiomac.2020.01.246	2020
Phylogeny	Outlook on next-generation probiotics from the human gut.	De Filippis F, Esposito A, Ercolini D.	Cell Mol Life Sci	10.1007/s00018-021-04080-6	2022
Phylogeny	An Akkermansia muciniphila subtype alleviates high-fat diet-induced metabolic disorders and inhibits the neurodegenerative process in mice.	Wu F, Guo X, Zhang M, Ou Z, Wu D, Deng L, Lu Z, Zhang J, Deng G, Chen S, Li S, Yi J, Peng Y.	Anaerobe	10.1016/j.anaerobe.2019.102138	2020
	Lactobacillus paragasseri OLL2809 Improves Depression-Like Behavior and Increases Beneficial Gut Microbes in Mice.	Hashikawa-Hobara N, Otsuka A, Okujima C, Hashikawa N.	Front Neurosci	10.3389/fnins.2022.918953	2022
	Biomimetic superabsorbent hydrogel acts as a gut protective dynamic exoskeleton improving metabolic parameters and expanding A. muciniphila.	Silvestri A, Gil-Gomez A, Vitale M, Braga D, Demitri C, Brescia P, Madaghiele M, Spadoni I, Jones B, Fornasa G, Mouries J, Carloni S, Lizier M, Romero-Gomez M, Penna G, Sannino A, Rescigno M.	Cell Rep Med	10.1016/j.xcrm.2023.101235	2023
	Gut Microbiota and B Cell Receptor (BCR) Inhibitors for the Treatment of Chronic Lymphocytic Leukemia: Is Biodiversity Correlated with Clinical Response or Immune-Related Adverse Event Occurrence? A Cross-Sectional Study.	Zuccaro V, Petazzoni G, Mileto I, Corbella M, Asperges E, Sacchi P, Rattotti S, Varettoni M, Defrancesco I, Cambieri P, Baldanti F, Arcaini L, Bruno R.	Microorganisms	10.3390/microorganisms11051305	2023
Pathogenicity	Akkermansia muciniphila Alleviates Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Mice.	Xu Y, Duan J, Wang D, Liu J, Chen X, Qin XY, Yu W.	Metabolites	10.3390/metabo13020194	2023
	Extracellular Vesicles of Probiotics: Shedding Light on the Biological Activity and Future Applications.	Krzyzek P, Marinacci B, Vitale I, Grande R.	Pharmaceutics	10.3390/pharmaceutics15020522	2023
	Interspecies commensal interactions have nonlinear impacts on host immunity.	Rice TA, Bielecka AA, Nguyen MT, Rosen CE, Song D, Sonnert ND, Yang Y, Cao Y, Khetrapal V, Catanzaro JR, Martin AL, Rashed SA, Leopold SR, Hao L, Yu X, van Dijk D, Ring AM, Flavell RA, de Zoete MR, Palm NW.	Cell Host Microbe	10.1016/j.chom.2022.05.004	2022
	Zonated Copper-Driven Breast Cancer Progression Countered by a Copper-Depleting Nanoagent for Immune and Metabolic Reprogramming.	Chen L, Ma S, Wu H, Zheng L, Yi Y, Liu G, Li B, Sun J, Du Y, Wang B, Liu Y, Zhang C, Chang J, Pang Y, Wang W, Wang M, Zhu M.	Adv Sci (Weinh)	10.1002/advs.202412434	2025
	Extracellular vesicles derived from Akkermansia muciniphila promote placentation and mitigate preeclampsia in a mouse model.	Chen Y, Ou Z, Pang M, Tao Z, Zheng X, Huang Z, Wen D, Li Q, Zhou R, Chen P, Situ B, Sheng C, Huang Y, Yue X, Zheng L, Huang L.	J Extracell Vesicles	10.1002/jev2.12328	2023
	Corrigendum: Akkermansia muciniphila as a Model Case for the Development of an Improved Quantitative RPA Microbiome Assay.	Goux HJ, Chavan D, Crum M, Kourentzi K, Willson RC.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00032	2019
	Microbiome and cancer: from mechanistic implications in disease progression and treatment to development of novel antitumoral strategies.	Constantin M, Chifiriuc MC, Mihaescu G, Corcionivoschi N, Burlibasa L, Bleotu C, Tudorache S, Mitache MM, Filip R, Munteanu SG, Gradisteanu Pircalabioru G.	Front Immunol	10.3389/fimmu.2024.1373504	2024
	Data-driven prediction of colonization outcomes for complex microbial communities.	Wu L, Wang XW, Tao Z, Wang T, Zuo W, Zeng Y, Liu YY, Dai L.	Nat Commun	10.1038/s41467-024-46766-y	2024
	Role of bacteria in cancers and their therapeutic potential: Review of current knowledge.	Wawrety W, Kedziora A.	Iran J Basic Med Sci	10.22038/ijbms.2024.77667.16798	2025
Metabolism	Akkermansia muciniphila Enhances Egg Quality and the Lipid Profile of Egg Yolk by Improving Lipid Metabolism.	Wei F, Yang X, Zhang M, Xu C, Hu Y, Liu D.	Front Microbiol	10.3389/fmicb.2022.927245	2022
	Polydopamine/chitosan layer-by-layer coating of Bacillus cereus enhances the robustness of live anti-oxidation materials for the treatment of radiation enteritis	Zhang F, Zeng L, Zuo J, Tan Y, Wang K, Li Z, Su Y, Hu Y, Chen Z, Hong J, Du L, Jin Y, Yuan B.	Mater Today Bio		2025
	Oral administration of Faecalibacterium prausnitzii and Akkermansia muciniphila strains from humans improves atopic dermatitis symptoms in DNCB induced NC/Nga mice.	Lee Y, Byeon HR, Jang SY, Hong MG, Kim D, Lee D, Shin JH, Kim Y, Kang SG, Seo JG.	Sci Rep	10.1038/s41598-022-11048-4	2022
Pathogenicity	GLP-1RAs attenuated obesity and reversed leptin resistance partly via activating the microbiome-derived inosine/A2A pathway.	Dong C, Zhou B, Zhao B, Lin K, Tian Y, Zhang R, Xie D, Wu S, Yang L.	Acta Pharm Sin B	10.1016/j.apsb.2024.12.006	2025
Genetics	A thousand metagenome-assembled genomes of Akkermansia reveal phylogroups and geographical and functional variations in the human gut.	Lv QB, Li S, Zhang Y, Guo R, Wang YC, Peng Y, Zhang XX.	Front Cell Infect Microbiol	10.3389/fcimb.2022.957439	2022
	Akkermansia muciniphila and Faecalibacterium prausnitzii in Immune-Related Diseases.	Effendi RMRA, Anshory M, Kalim H, Dwiyana RF, Suwarsa O, Pardo LM, Nijsten TEC, Thio HB.	Microorganisms	10.3390/microorganisms10122382	2022
	Correlating the Gut Microbiota and Circulating Hormones with Acne Lesion Counts and Skin Biophysical Features.	Sivamani RK, Maloh J, Nong Y.	Microorganisms	10.3390/microorganisms11082049	2023
Pathogenicity	The Use of Microbial Modifying Therapies to Prevent Psoriasis Exacerbation and Associated Cardiovascular Comorbidity.	Reali E, Caliceti C, Lorenzini A, Rizzo P.	Inflammation	10.1007/s10753-023-01915-1	2024
	Turning universal O into rare Bombay type blood.	Anso I, Naegeli A, Cifuente JO, Orrantia A, Andersson E, Zenarruzabeitia O, Moraleda-Montoya A, Garcia-Alija M, Corzana F, Del Orbe RA, Borrego F, Trastoy B, Sjogren J, Guerin ME.	Nat Commun	10.1038/s41467-023-37324-z	2023
Enzymology	Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice.	Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00239	2019
	Safety of pasteurised Akkermansia muciniphila as a novel food pursuant to Regulation (EU) 2015/2283.	EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, Bohn T, Castenmiller J, De Henauw S, Hirsch-Ernst KI, Maciuk A, Mangelsdorf I, McArdle HJ, Naska A, Pelaez C, Pentieva K, Siani A, Thies F, Tsabouri S, Vinceti M, Cubadda F, Frenzel T, Heinonen M, Marchelli R, Neuhauser-Berthold M, Poulsen M, Prieto Maradona M, Schlatter JR, van Loveren H, Ackerl R, Knutsen HK.	EFSA J	10.2903/j.efsa.2021.6780	2021
	Dietary Boswellia serrata Acid Alters the Gut Microbiome and Blood Metabolites in Experimental Models.	Suther C, Daddi L, Bokoliya S, Panier H, Liu Z, Lin Q, Han Y, Chen K, Moore MD, Zhou Y.	Nutrients	10.3390/nu14040814	2022
	Experimental evaluation of ecological principles to understand and modulate the outcome of bacterial strain competition in gut microbiomes.	Segura Munoz RR, Mantz S, Martinez I, Li F, Schmaltz RJ, Pudlo NA, Urs K, Martens EC, Walter J, Ramer-Tait AE.	ISME J	10.1038/s41396-022-01208-9	2022
Metabolism	Pasteurized Akkermansia muciniphila Reduces Fat Accumulation via nhr-49-Mediated Nuclear Hormone Signaling Pathway in Caenorhabditis elegans.	Wu Z, Xiao Y, Zhou F, Chen J, Chen X, Hou A, Wang Y, Li Z.	Molecules	10.3390/molecules27196159	2022
Metabolism	Microbiome and spatially resolved metabolomics analysis reveal the anticancer role of gut Akkermansia muciniphila by crosstalk with intratumoral microbiota and reprogramming tumoral metabolism in mice.	Zhu Z, Cai J, Hou W, Xu K, Wu X, Song Y, Bai C, Mo YY, Zhang Z.	Gut Microbes	10.1080/19490976.2023.2166700	2023
Pathogenicity	Microbial and host factors contribute to bloodstream infection in a pediatric acute lymphocytic leukemia mouse model.	Song Y, Perlman K, Gyarmati P.	Heliyon	10.1016/j.heliyon.2022.e11340	2022
	Stronger gut microbiome modulatory effects by postbiotics than probiotics in a mouse colitis model.	Zhang T, Zhang W, Feng C, Kwok LY, He Q, Sun Z.	NPJ Sci Food	10.1038/s41538-022-00169-9	2022
	Effects of Akkermansia muciniphila and Faecalibacterium prausnitzii on serotonin transporter expression in intestinal epithelial cells.	Yaghoubfar R, Behrouzi A, Fateh A, Nojoumi SA, Vaziri F, Khatami S, Siadat SD.	J Diabetes Metab Disord	10.1007/s40200-020-00539-8	2021
	Probiotics and postbiotics in colorectal cancer: Prevention and complementary therapy.	Kvakova M, Kamlarova A, Stofilova J, Benetinova V, Bertkova I.	World J Gastroenterol	10.3748/wjg.v28.i27.3370	2022
	Akkermansia muciniphila administration exacerbated the development of colitis-associated colorectal cancer in mice.	Wang F, Cai K, Xiao Q, He L, Xie L, Liu Z.	J Cancer	10.7150/jca.63578	2022
	Native and Engineered Probiotics: Promising Agents against Related Systemic and Intestinal Diseases.	Shen H, Zhao Z, Zhao Z, Chen Y, Zhang L.	Int J Mol Sci	10.3390/ijms23020594	2022
	The Concept of Postbiotics.	Vinderola G, Sanders ME, Salminen S.	Foods	10.3390/foods11081077	2022
	Interrelated Effects of Zinc Deficiency and the Microbiome on Group B Streptococcal Vaginal Colonization.	Burcham LR, Burcham ZM, Akbari MS, Metcalf JL, Doran KS.	mSphere	10.1128/msphere.00264-22	2022
	The identification of metabolites from gut microbiota in NAFLD via network pharmacology.	Oh KK, Gupta H, Min BH, Ganesan R, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Jeong MK, Hyun JY, Eom JA, Park HJ, Yoon SJ, Choi MR, Kim DJ, Suk KT.	Sci Rep	10.1038/s41598-023-27885-w	2023
	Effects of active, inactive, and derivatives of Akkermansia muciniphila on the expression of the endocannabinoid system and PPARs genes.	Ghaderi F, Sotoodehnejadnematalahi F, Hajebrahimi Z, Fateh A, Siadat SD.	Sci Rep	10.1038/s41598-022-13840-8	2022
	Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism.	Duan C, Wu J, Wang Z, Tan C, Hou L, Qian W, Han C, Hou X.	Gut Microbes	10.1080/19490976.2023.2233149	2023
	Akkermansia Muciniphila Potentiates the Antitumor Efficacy of FOLFOX in Colon Cancer.	Hou X, Zhang P, Du H, Chu W, Sun R, Qin S, Tian Y, Zhang Z, Xu F.	Front Pharmacol	10.3389/fphar.2021.725583	2021
Metabolism	Structural basis of mammalian mucin processing by the human gut O-glycopeptidase OgpA from Akkermansia muciniphila.	Trastoy B, Naegeli A, Anso I, Sjogren J, Guerin ME.	Nat Commun	10.1038/s41467-020-18696-y	2020
Enzymology	Akkermansia muciniphila as a Model Case for the Development of an Improved Quantitative RPA Microbiome Assay.	Goux HJ, Chavan D, Crum M, Kourentzi K, Willson RC.	Front Cell Infect Microbiol	10.3389/fcimb.2018.00237	2018
	The Interplay of Dietary Fibers and Intestinal Microbiota Affects Type 2 Diabetes by Generating Short-Chain Fatty Acids.	Mazhar M, Zhu Y, Qin L.	Foods	10.3390/foods12051023	2023
Genetics	Comparative genomic and functional analysis of Akkermansia muciniphila and closely related species.	Xing J, Li X, Sun Y, Zhao J, Miao S, Xiong Q, Zhang Y, Zhang G.	Genes Genomics	10.1007/s13258-019-00855-1	2019
	Akkermansia muciniphila Colonization Alleviating High Fructose and Restraint Stress-Induced Jejunal Mucosal Barrier Disruption.	Yu J, Liu T, Gao Z, Liu R, Wang Z, Chen Y, Cao J, Dong Y.	Nutrients	10.3390/nu14153164	2022
	Engineered Akkermansia muciniphila: A promising agent against diseases (Review).	Zou Y, Chen T.	Exp Ther Med	10.3892/etm.2020.9415	2020
	Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types.	Cai X, Cho JY, Chen L, Liu Y, Ji F, Salgado K, Ge S, Yang D, Yu H, Shao J, Futreal PA, Sepesi B, Gibbons D, Chen Y, Wang G, Cheng C, Wu M, Zhang J, Hsiao A, Xia T.	iScience	10.1016/j.isci.2025.112162	2025
	Gut Microbiota-Derived 3-Hydroxybutyrate Blocks GPR43-Mediated IL6 Signaling to Ameliorate Radiation Proctopathy.	Ge Z, Chen C, Chen J, Jiang Z, Chen L, Wei Y, Chen H, He L, Zou Y, Long X, Zhan H, Wang H, Wang H, Lu Y.	Adv Sci (Weinh)	10.1002/advs.202306217	2024
	Social Hierarchy Dictates Intestinal Radiation Injury in a Gut Microbiota-Dependent Manner.	Zeng X, Liu Z, Dong Y, Zhao J, Wang B, Xiao H, Li Y, Chen Z, Liu X, Liu J, Dong J, Fan S, Cui M.	Int J Mol Sci	10.3390/ijms232113189	2022
Pathogenicity	Akkermansia muciniphila strain ATCC BAA-835 does not promote short-term intestinal inflammation in gnotobiotic interleukin-10-deficient mice.	Ring C, Klopfleisch R, Dahlke K, Basic M, Bleich A, Blaut M.	Gut Microbes	10.1080/19490976.2018.1511663	2019
Genetics	Genomic Evidence for Bacterial Determinants Influencing Obesity Development.	Isokpehi RD, Simmons SS, Johnson MO, Payton M.	Int J Environ Res Public Health	10.3390/ijerph14040345	2017
	Crystal structure of monomeric Amuc_1100 from Akkermansia muciniphila.	Mou L, Peng X, Chen Y, Xiao Q, Liao H, Liu M, Guo L, Liu Y, Zhang X, Deng D.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x20004124	2020
Pathogenicity	The biological activity and potential of probiotics-derived extracellular vesicles as postbiotics in modulating microbiota-host communication.	Zhang X, Wang Y, E Q, Naveed M, Wang X, Liu Y, Li M.	J Nanobiotechnology	10.1186/s12951-025-03435-6	2025
Metabolism	Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis.	Rao Y, Kuang Z, Li C, Guo S, Xu Y, Zhao D, Hu Y, Song B, Jiang Z, Ge Z, Liu X, Li C, Chen S, Ye J, Huang Z, Lu Y.	Gut Microbes	10.1080/19490976.2021.1927633	2021
	Study of growth, metabolism, and morphology of Akkermansia muciniphila with an in vitro advanced bionic intestinal reactor.	Li Z, Hu G, Zhu L, Sun Z, Jiang Y, Gao MJ, Zhan X.	BMC Microbiol	10.1186/s12866-021-02111-7	2021
Genetics	Genome sequencing of 39 Akkermansia muciniphila isolates reveals its population structure, genomic and functional diverisity, and global distribution in mammalian gut microbiotas.	Guo X, Li S, Zhang J, Wu F, Li X, Wu D, Zhang M, Ou Z, Jie Z, Yan Q, Li P, Yi J, Peng Y.	BMC Genomics	10.1186/s12864-017-4195-3	2017
	A novel peptide protects against diet-induced obesity by suppressing appetite and modulating the gut microbiota.	Li Z, Zhang B, Wang N, Zuo Z, Wei H, Zhao F.	Gut	10.1136/gutjnl-2022-328035	2023
	A Continuous Battle for Host-Derived Glycans Between a Mucus Specialist and a Glycan Generalist in vitro and in vivo.	Kostopoulos I, Aalvink S, Kovatcheva-Datchary P, Nijsse B, Backhed F, Knol J, de Vos WM, Belzer C.	Front Microbiol	10.3389/fmicb.2021.632454	2021
Genetics	Genome-wide multi-omics analysis reveals the nutrient-dependent metabolic features of mucin-degrading gut bacteria.	Kim KS, Tiffany E, Lee JY, Oh A, Jin HS, Kim JS, Lee JS, Nam MH, Hong SJ, Park S, Koh H, Kim BS, Lee YK, Lee DW.	Gut Microbes	10.1080/19490976.2023.2221811	2023
Enzymology	Structure and function of microbial alpha-l-fucosidases: a mini review.	Wu H, Owen CD, Juge N.	Essays Biochem	10.1042/ebc20220158	2023
	Health and Disease: Akkermansia muciniphila, the Shining Star of the Gut Flora.	Xue C, Li G, Gu X, Su Y, Zheng Q, Yuan X, Bao Z, Lu J, Li L.	Research (Wash D C)	10.34133/research.0107	2023
Pathogenicity	Akkermansia muciniphila and Its Pili-Like Protein Amuc_1100 Modulate Macrophage Polarization in Experimental Periodontitis.	Mulhall H, DiChiara JM, Deragon M, Iyer R, Huck O, Amar S.	Infect Immun	10.1128/iai.00500-20	2020
	Arylsulfamates inhibit colonic Bacteroidota growth through a sulfatase-independent mechanism.	Crawford CJ, Tomlinson CWE, Gunawan C, Chen Z, Byrne DP, Darby C, Conti MLG, Larson T, Luis AS, Elli S, Yates EA, Bolam DN, van der Post S, Williams SJ, Cartmell A.	Proc Natl Acad Sci U S A	10.1073/pnas.2414331122	2025
	Loureirin A is a narrow-spectrum antimicrobial agent against Helicobacter pylori.	Tong Q, Yin C, Hang X, Bai Y, Zhang C, Xu J, Huang Y, Ge Y, Chen T, Zeng L, Jia J, Bi H.	Antimicrob Agents Chemother	10.1128/aac.00314-24	2024
	Identification of Gut Microbiome Metabolites via Network Pharmacology Analysis in Treating Alcoholic Liver Disease.	Oh KK, Choi YR, Gupta H, Ganesan R, Sharma SP, Won SM, Jeong JJ, Lee SB, Cha MG, Kwon GH, Kim DJ, Suk KT.	Curr Issues Mol Biol	10.3390/cimb44070224	2022
Metabolism	Characterization of a phospholipid-regulated beta-galactosidase from Akkermansia muciniphila involved in mucin degradation.	Kosciow K, Deppenmeier U.	Microbiologyopen	10.1002/mbo3.796	2019
	The Protective Effects of Live and Pasteurized Akkermansia muciniphila and Its Extracellular Vesicles against HFD/CCl4-Induced Liver Injury.	Keshavarz Azizi Raftar S, Ashrafian F, Yadegar A, Lari A, Moradi HR, Shahriary A, Azimirad M, Alavifard H, Mohsenifar Z, Davari M, Vaziri F, Moshiri A, Siadat SD, Zali MR.	Microbiol Spectr	10.1128/spectrum.00484-21	2021
	Anti-obesity Effect of Capsaicin in Mice Fed with High-Fat Diet Is Associated with an Increase in Population of the Gut Bacterium Akkermansia muciniphila.	Shen W, Shen M, Zhao X, Zhu H, Yang Y, Lu S, Tan Y, Li G, Li M, Wang J, Hu F, Le S.	Front Microbiol	10.3389/fmicb.2017.00272	2017
Metabolism	A Purified Aspartic Protease from Akkermansia Muciniphila Plays an Important Role in Degrading Muc2.	Meng X, Wang W, Lan T, Yang W, Yu D, Fang X, Wu H.	Int J Mol Sci	10.3390/ijms21010072	2019
	Oral Supplementation of Lead-Intolerant Intestinal Microbes Protects Against Lead (Pb) Toxicity in Mice.	Zhai Q, Qu D, Feng S, Yu Y, Yu L, Tian F, Zhao J, Zhang H, Chen W.	Front Microbiol	10.3389/fmicb.2019.03161	2019
	Beneficial Effects of Newly Isolated Akkermansia muciniphila Strains from the Human Gut on Obesity and Metabolic Dysregulation.	Yang M, Bose S, Lim S, Seo J, Shin J, Lee D, Chung WH, Song EJ, Nam YD, Kim H.	Microorganisms	10.3390/microorganisms8091413	2020
Pathogenicity	Low-Intensity Exercise Modulates Gut Microbiota to Fight Against Radiation-Induced Gut Toxicity in Mouse Models.	Wang B, Jin YX, Dong JL, Xiao HW, Zhang SQ, Li Y, Chen ZY, Yang XD, Fan SJ, Cui M.	Front Cell Dev Biol	10.3389/fcell.2021.706755	2021
Pathogenicity	Revisiting the role of Akkermansia muciniphila as a therapeutic bacterium.	Si J, Kang H, You HJ, Ko G.	Gut Microbes	10.1080/19490976.2022.2078619	2022
	Gastrointestinal Dysmotility Predisposes to Colitis through Regulation of Gut Microbial Composition and Linoleic Acid Metabolism.	Zhang Y, Song F, Yang M, Chen C, Cui J, Xing M, Dai Y, Li M, Cao Y, Lu L, Zhu H, Liu Y, Ma C, Wei Q, Qin H, Li J.	Adv Sci (Weinh)	10.1002/advs.202306297	2024
Metabolism	Intestinal colonization regulates systemic anti-commensal immune sensitivity and hyperreactivity.	Burkhard R, Koegler M, Brown K, Wilson K, Mager LF, Zucoloto AZ, Thomson C, Hebbandi Nanjundappa R, Skalosky I, Ahmadi S, McDonald B, Geuking MB.	Front Immunol	10.3389/fimmu.2023.1030395	2023
Enzymology	Different subtype strains of Akkermansia muciniphila abundantly colonize in southern China.	Guo X, Zhang J, Wu F, Zhang M, Yi M, Peng Y.	J Appl Microbiol	10.1111/jam.13022	2016
	GH20 and GH84 beta-N-acetylglucosaminidases with different linkage specificities underpin mucin O-glycan breakdown capability of Bifidobacterium bifidum.	Takada H, Katoh T, Sakanaka M, Odamaki T, Katayama T.	J Biol Chem	10.1016/j.jbc.2023.104781	2023
	Antagonism Between Gut Ruminococcus gnavus and Akkermansia muciniphila Modulates the Progression of Chronic Hepatitis B.	Chua HH, Chen YH, Wu LL, Yang HC, Lin CR, Chen HL, Wu JF, Chang MH, Chen PJ, Ni YH.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2023.12.003	2024
	Gut microbiome at the crossroad of genetic variants and behavior disorders.	Cheng L, Wu H, Chen Z, Hao H, Zheng X.	Gut Microbes	10.1080/19490976.2023.2201156	2023
	A purified membrane protein from Akkermansia muciniphila or the pasteurised bacterium blunts colitis associated tumourigenesis by modulation of CD8⁺ T cells in mice.	Wang L, Tang L, Feng Y, Zhao S, Han M, Zhang C, Yuan G, Zhu J, Cao S, Wu Q, Li L, Zhang Z.	Gut	10.1136/gutjnl-2019-320105	2020
Genetics	Microbial characterization based on multifractal analysis of metagenomes.	Xie XH, Huang YJ, Han GS, Yu ZG, Ma YL.	Front Cell Infect Microbiol	10.3389/fcimb.2023.1117421	2023
Pathogenicity	Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8⁺ T Cells and Macrophages.	Luo ZW, Xia K, Liu YW, Liu JH, Rao SS, Hu XK, Chen CY, Xu R, Wang ZX, Xie H.	Int J Nanomedicine	10.2147/ijn.s304515	2021
	Spinal fluid IgG antibodies from patients with demyelinating diseases bind multiple sclerosis-associated bacteria.	Eckman E, Laman JD, Fischer KF, Lopansri B, Martins TB, Hill HR, Kriesel JD.	J Mol Med (Berl)	10.1007/s00109-021-02085-z	2021
Metabolism	Rationally designed bacterial consortia to treat chronic immune-mediated colitis and restore intestinal homeostasis.	van der Lelie D, Oka A, Taghavi S, Umeno J, Fan TJ, Merrell KE, Watson SD, Ouellette L, Liu B, Awoniyi M, Lai Y, Chi L, Lu K, Henry CS, Sartor RB.	Nat Commun	10.1038/s41467-021-23460-x	2021
	Role of the gut microbiome in three major psychiatric disorders.	Borkent J, Ioannou M, Laman JD, Haarman BCM, Sommer IEC, Sommer IEC.	Psychol Med	10.1017/s0033291722000897	2022
	Comparative analysis of prebiotic effects of four oligosaccharides using in vitro gut model: digestibility, microbiome, and metabolome changes.	Cheon S, Kim G, Bae JH, Lee DH, Seong H, Kim DH, Han JS, Lim SY, Han NS.	FEMS Microbiol Ecol	10.1093/femsec/fiad002	2023
	Akkermansia muciniphila prevents cold-related atrial fibrillation in rats by modulation of TMAO induced cardiac pyroptosis.	Luo Y, Zhang Y, Han X, Yuan Y, Zhou Y, Gao Y, Yu H, Zhang J, Shi Y, Duan Y, Zhao X, Yan S, Hao H, Dai C, Zhao S, Shi J, Li W, Zhang S, Xu W, Fang N, Gong Y, Li Y.	EBioMedicine	10.1016/j.ebiom.2022.104087	2022
Phylogeny	Genomic diversity and ecology of human-associated Akkermansia species in the gut microbiome revealed by extensive metagenomic assembly.	Karcher N, Nigro E, Puncochar M, Blanco-Miguez A, Ciciani M, Manghi P, Zolfo M, Cumbo F, Manara S, Golzato D, Cereseto A, Arumugam M, Bui TPN, Tytgat HLP, Valles-Colomer M, de Vos WM, Segata N.	Genome Biol	10.1186/s13059-021-02427-7	2021
Metabolism	Extracellular vesicles and pasteurized cells derived from Akkermansia muciniphila protect against high-fat induced obesity in mice.	Ashrafian F, Keshavarz Azizi Raftar S, Lari A, Shahryari A, Abdollahiyan S, Moradi HR, Masoumi M, Davari M, Khatami S, Omrani MD, Vaziri F, Masotti A, Siadat SD.	Microb Cell Fact	10.1186/s12934-021-01709-w	2021
Pathogenicity	Comparative study of effect of Akkermansia muciniphila and its extracellular vesicles on toll-like receptors and tight junction.	Ashrafian F, Behrouzi A, Shahriary A, Ahmadi Badi S, Davari M, Khatami S, Rahimi Jamnani F, Fateh A, Vaziri F, Siadat SD.	Gastroenterol Hepatol Bed Bench		2019
	Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection.	Hu X, Zhao Y, Yang Y, Gong W, Sun X, Yang L, Zhang Q, Jin M.	Front Microbiol	10.3389/fmicb.2020.586476	2020
	Disruption of the Intestinal Mucosal Barrier Induced by High Fructose and Restraint Stress Is Regulated by the Intestinal Microbiota and Microbiota Metabolites.	Yu J, Liu T, Guo Q, Wang Z, Chen Y, Dong Y.	Microbiol Spectr	10.1128/spectrum.04698-22	2023
	Effects of Live and Pasteurized Forms of Akkermansia from the Human Gut on Obesity and Metabolic Dysregulation.	Choi Y, Bose S, Seo J, Shin JH, Lee D, Kim Y, Kang SG, Kim H.	Microorganisms	10.3390/microorganisms9102039	2021
Pathogenicity	Unravelling the antimicrobial action of antidepressants on gut commensal microbes.	Ait Chait Y, Mottawea W, Tompkins TA, Hammami R.	Sci Rep	10.1038/s41598-020-74934-9	2020
	Utilization Efficiency of Human Milk Oligosaccharides by Human-Associated Akkermansia Is Strain Dependent.	Luna E, Parkar SG, Kirmiz N, Hartel S, Hearn E, Hossine M, Kurdian A, Mendoza C, Orr K, Padilla L, Ramirez K, Salcedo P, Serrano E, Choudhury B, Paulchakrabarti M, Parker CT, Huynh S, Cooper K, Flores GE.	Appl Environ Microbiol	10.1128/aem.01487-21	2022
Pathogenicity	Structural Characterization of a Polysaccharide from Gastrodia elata and Its Bioactivity on Gut Microbiota.	Huo J, Lei M, Li F, Hou J, Zhang Z, Long H, Zhong X, Liu Y, Xie C, Wu W.	Molecules	10.3390/molecules26154443	2021
Pathogenicity	Comparative effects of alive and pasteurized Akkermansia muciniphila on normal diet-fed mice.	Ashrafian F, Keshavarz Azizi Raftar S, Shahryari A, Behrouzi A, Yaghoubfar R, Lari A, Moradi HR, Khatami S, Omrani MD, Vaziri F, Masotti A, Siadat SD.	Sci Rep	10.1038/s41598-021-95738-5	2021
Metabolism	Synthetic Microbiomes on the Rise-Application in Deciphering the Role of Microbes in Host Health and Disease.	Bolsega S, Bleich A, Basic M.	Nutrients	10.3390/nu13114173	2021
	Akkermansia muciniphila protects intestinal mucosa from damage caused by S. pullorum by initiating proliferation of intestinal epithelium.	Zhu L, Lu X, Liu L, Voglmeir J, Zhong X, Yu Q.	Vet Res	10.1186/s13567-020-00755-3	2020
	Synthetic microbial consortia for the treatment of Clostridioides difficile infection in mice model.	Liu J, Zhu W, Lessing DJ, Chu W.	Microb Biotechnol	10.1111/1751-7915.14333	2023
	Nucleotide binding as an allosteric regulatory mechanism for Akkermansia muciniphila beta-N-acetylhexosaminidase Am2136.	Li CC, Yi H, Wang YM, Tang XY, Zhu YB, Song YJ, Zhao NL, Huang Q, Mou XY, Luo GH, Liu TG, Yang GL, Zeng YJ, Wang LJ, Tang H, Fan G, Bao R.	Gut Microbes	10.1080/19490976.2022.2143221	2022
Phylogeny	Genome and pan-genome analysis to classify emerging bacteria.	Caputo A, Fournier PE, Raoult D.	Biol Direct	10.1186/s13062-019-0234-0	2019
	Function of Akkermansia muciniphila in Obesity: Interactions With Lipid Metabolism, Immune Response and Gut Systems.	Xu Y, Wang N, Tan HY, Li S, Zhang C, Feng Y.	Front Microbiol	10.3389/fmicb.2020.00219	2020
	Maternal Intake of Probiotics to Program Offspring Health.	Cuinat C, Stinson SE, Ward WE, Comelli EM.	Curr Nutr Rep	10.1007/s13668-022-00429-w	2022
	Akkermansia muciniphila Enhances the Antitumor Effect of Cisplatin in Lewis Lung Cancer Mice.	Chen Z, Qian X, Chen S, Fu X, Ma G, Zhang A.	J Immunol Res	10.1155/2020/2969287	2020
Pathogenicity	Intestinal Epithelial Axin1 Deficiency Protects Against Colitis via Altered Gut Microbiota.	Garrett S, Zhang Y, Xia Y, Sun J.	Engineering (Beijing)	10.1016/j.eng.2023.06.007	2024
	Nanopore Sequencing of Amoebophrya Species Reveals Novel Collection of Bacteria Putatively Associated With Karlodinium veneficum.	Tizabi D, Hill RT, Bachvaroff T.	Genome Biol Evol	10.1093/gbe/evaf022	2025
Metabolism	Akkermansia muciniphila uses human milk oligosaccharides to thrive in the early life conditions in vitro.	Kostopoulos I, Elzinga J, Ottman N, Klievink JT, Blijenberg B, Aalvink S, Boeren S, Mank M, Knol J, de Vos WM, Belzer C.	Sci Rep	10.1038/s41598-020-71113-8	2020
	The anti-inflammatory effects of Akkermansia muciniphila and its derivates in HFD/CCL4-induced murine model of liver injury.	Raftar SKA, Ashrafian F, Abdollahiyan S, Yadegar A, Moradi HR, Masoumi M, Vaziri F, Moshiri A, Siadat SD, Zali MR.	Sci Rep	10.1038/s41598-022-06414-1	2022
	Molecular Insights Into O-Linked Glycan Utilization by Gut Microbes.	Gonzalez-Morelo KJ, Vega-Sagardia M, Garrido D.	Front Microbiol	10.3389/fmicb.2020.591568	2020
	MUP1 mediates urolithin A alleviation of chronic alcohol-related liver disease via gut-microbiota-liver axis.	Zhang H, Li C, Han L, Xiao Y, Bian J, Liu C, Gong L, Liu Z, Wang M.	Gut Microbes	10.1080/19490976.2024.2367342	2024
	Stable colonization of Akkermansia muciniphila educates host intestinal microecology and immunity to battle against inflammatory intestinal diseases.	Wang B, Chen X, Chen Z, Xiao H, Dong J, Li Y, Zeng X, Liu J, Wan G, Fan S, Cui M.	Exp Mol Med	10.1038/s12276-022-00911-z	2023
Genetics	Comparative Genomics Guides Elucidation of Vitamin B₁₂ Biosynthesis in Novel Human-Associated Akkermansia Strains.	Kirmiz N, Galindo K, Cross KL, Luna E, Rhoades N, Podar M, Flores GE.	Appl Environ Microbiol	10.1128/aem.02117-19	2020
	Increased circulating butyrate and ursodeoxycholate during probiotic intervention in humans with type 2 diabetes.	McMurdie PJ, Stoeva MK, Justice N, Nemchek M, Sieber CMK, Tyagi S, Gines J, Skennerton CT, Souza M, Kolterman O, Eid J.	BMC Microbiol	10.1186/s12866-021-02415-8	2022
	Lactobacillus acidophilus potentiates oncolytic virotherapy through modulating gut microbiota homeostasis in hepatocellular carcinoma.	Zhang J, Yang J, Luo J, Wu W, Luo H, Wei W, Lyu H, Wang Y, Yi H, Zhang Y, Fan Z, Lyu H, Kanakaveti VP, Qin B, Yuan P, Yang R, Zhang H, Zuo T, Felsher DW, Lee MH, Li K.	Nat Commun	10.1038/s41467-025-58407-z	2025
Metabolism	Mucin degrader Akkermansia muciniphila accelerates intestinal stem cell-mediated epithelial development.	Kim S, Shin YC, Kim TY, Kim Y, Lee YS, Lee SH, Kim MN, O E, Kim KS, Kweon MN.	Gut Microbes	10.1080/19490976.2021.1892441	2021
Genetics	Whole-genome assembly of Akkermansia muciniphila sequenced directly from human stool.	Caputo A, Dubourg G, Croce O, Gupta S, Robert C, Papazian L, Rolain JM, Raoult D.	Biol Direct	10.1186/s13062-015-0041-1	2015
	Tauroursodeoxycholic acid functions as a critical effector mediating insulin sensitization of metformin in obese mice.	Zhang Y, Cheng Y, Liu J, Zuo J, Yan L, Thring RW, Ba X, Qi D, Wu M, Gao Y, Tong H.	Redox Biol	10.1016/j.redox.2022.102481	2022
Pathogenicity	The Microbiota-Dependent Worsening Effects of Melatonin on Gut Inflammation.	da Silva JL, Barbosa LV, Pinzan CF, Nardini V, Brigo IS, Sebastiao CA, Elias-Oliveira J, Brazao V, Junior JCDP, Carlos D, Cardoso CRB.	Microorganisms	10.3390/microorganisms11020460	2023
Metabolism	Modulation of serotonin signaling/metabolism by Akkermansia muciniphila and its extracellular vesicles through the gut-brain axis in mice.	Yaghoubfar R, Behrouzi A, Ashrafian F, Shahryari A, Moradi HR, Choopani S, Hadifar S, Vaziri F, Nojoumi SA, Fateh A, Khatami S, Siadat SD.	Sci Rep	10.1038/s41598-020-79171-8	2020
	Interaction of mouse splenocytes and macrophages with bacterial strains in vitro: the effect of age in the immune response.	Van Beek AA, Hoogerland JA, Belzer C, De Vos P, De Vos WM, Savelkoul HF, Leenen PJ.	Benef Microbes	10.3920/bm2015.0094	2016
	The Regulation of Nucleic Acid Vaccine Responses by the Microbiome.	Johnson AMF, Hager K, Alameh MG, Van P, Potchen N, Mayer-Blackwell K, Fiore-Gartland A, Minot S, Lin PJC, Tam YK, Weissman D, Kublin JG.	J Immunol	10.4049/jimmunol.2300196	2023
Metabolism	Model-driven design of a minimal medium for Akkermansia muciniphila confirms mucus adaptation.	van der Ark KCH, Aalvink S, Suarez-Diez M, Schaap PJ, de Vos WM, Belzer C.	Microb Biotechnol	10.1111/1751-7915.13033	2018
	A novel monoclonal IgG1 antibody specific for Galactose-alpha-1,3-galactose questions alpha-Gal epitope expression by bacteria.	Kreft L, Schepers A, Hils M, Swiontek K, Flatley A, Janowski R, Mirzaei MK, Dittmar M, Chakrapani N, Desai MS, Eyerich S, Deng L, Niessing D, Fischer K, Feederle R, Blank S, Schmidt-Weber CB, Hilger C, Biedermann T, Ohnmacht C.	Front Immunol	10.3389/fimmu.2022.958952	2022
	A genetic system for Akkermansia muciniphila reveals a role for mucin foraging in gut colonization and host sterol biosynthesis gene expression.	Davey LE, Malkus PN, Villa M, Dolat L, Holmes ZC, Letourneau J, Ansaldo E, David LA, Barton GM, Valdivia RH.	Nat Microbiol	10.1038/s41564-023-01407-w	2023
	HLA-II immunopeptidome profiling and deep learning reveal features of antigenicity to inform antigen discovery.	Strazar M, Park J, Abelin JG, Taylor HB, Pedersen TK, Plichta DR, Brown EM, Eraslan B, Hung YM, Ortiz K, Clauser KR, Carr SA, Xavier RJ, Graham DB.	Immunity	10.1016/j.immuni.2023.05.009	2023
Pathogenicity	Akkermansia muciniphila-Derived Extracellular Vesicles as a Mucosal Delivery Vector for Amelioration of Obesity in Mice.	Ashrafian F, Shahriary A, Behrouzi A, Moradi HR, Keshavarz Azizi Raftar S, Lari A, Hadifar S, Yaghoubfar R, Ahmadi Badi S, Khatami S, Vaziri F, Siadat SD.	Front Microbiol	10.3389/fmicb.2019.02155	2019
	GlcNac produced by the gut microbiome enhances host influenza resistance by modulating NK cells.	Hu X, Sun X, Zhao Y, Iv C, Sun X, Jin M, Zhang Q.	Gut Microbes	10.1080/19490976.2023.2271620	2023
	Polyphenols as Drivers of a Homeostatic Gut Microecology and Immuno-Metabolic Traits of Akkermansia muciniphila: From Mouse to Man.	Rodriguez-Daza MC, de Vos WM.	Int J Mol Sci	10.3390/ijms24010045	2022
	Dynamic metabolic interactions and trophic roles of human gut microbes identified using a minimal microbiome exhibiting ecological properties.	Shetty SA, Kostopoulos I, Geerlings SY, Smidt H, de Vos WM, Belzer C.	ISME J	10.1038/s41396-022-01255-2	2022
Pathogenicity	A mucin-regulated adhesin determines the spatial organization and inflammatory character of a bacterial symbiont in the vertebrate gut.	Smith TJ, Sundarraman D, Melancon E, Desban L, Parthasarathy R, Guillemin K.	Cell Host Microbe	10.1016/j.chom.2023.07.003	2023
	The effects of sodium butyrate and inulin supplementation on angiotensin signaling pathway via promotion of Akkermansia muciniphila abundance in type 2 diabetes; A randomized, double-blind, placebo-controlled trial.	Roshanravan N, Mahdavi R, Alizadeh E, Ghavami A, Rahbar Saadat Y, Mesri Alamdari N, Alipour S, Dastouri MR, Ostadrahimi A.	J Cardiovasc Thorac Res	10.15171/jcvtr.2017.32	2017
Metabolism	Modulation of the gut microbiota by metformin improves metabolic profiles in aged obese mice.	Lee H, Lee Y, Kim J, An J, Lee S, Kong H, Song Y, Lee CK, Kim K.	Gut Microbes	10.1080/19490976.2017.1405209	2018
	Functional environmental screening of a metagenomic library identifies stlA; a unique salt tolerance locus from the human gut microbiome.	Culligan EP, Sleator RD, Marchesi JR, Hill C.	PLoS One	10.1371/journal.pone.0082985	2013
Metabolism	Maternal Exposure to Non-nutritive Sweeteners Impacts Progeny's Metabolism and Microbiome.	Olivier-Van Stichelen S, Rother KI, Hanover JA.	Front Microbiol	10.3389/fmicb.2019.01360	2019
	Diet-derived metabolites and mucus link the gut microbiome to fever after cytotoxic cancer treatment.	Schwabkey ZI, Wiesnoski DH, Chang CC, Tsai WB, Pham D, Ahmed SS, Hayase T, Ortega Turrubiates MR, El-Himri RK, Sanchez CA, Hayase E, Frenk Oquendo AC, Miyama T, Halsey TM, Heckel BE, Brown AN, Jin Y, Raybaud M, Prasad R, Flores I, McDaniel L, Chapa V, Lorenzi PL, Warmoes MO, Tan L, Swennes AG, Fowler S, Conner M, McHugh K, Graf T, Jensen VB, Peterson CB, Do KA, Zhang L, Shi Y, Wang Y, Galloway-Pena JR, Okhuysen PC, Daniel-MacDougall CR, Shono Y, Burgos da Silva M, Peled JU, van den Brink MRM, Ajami N, Wargo JA, Reddy P, Valdivia RH, Davey L, Rondon G, Srour SA, Mehta RS, Alousi AM, Shpall EJ, Champlin RE, Shelburne SA, Molldrem JJ, Jamal MA, Karmouch JL, Jenq RR.	Sci Transl Med	10.1126/scitranslmed.abo3445	2022
	Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.	Sharma A, Sharma G, Im SH.	Gut Microbes	10.1080/19490976.2025.2516702	2025
	Toxicological safety evaluation of pasteurized Akkermansia muciniphila.	Druart C, Plovier H, Van Hul M, Brient A, Phipps KR, de Vos WM, Cani PD.	J Appl Toxicol	10.1002/jat.4044	2021
	Research advances in the therapy of metabolic syndrome.	Lin Z, Sun L.	Front Pharmacol	10.3389/fphar.2024.1364881	2024
	Actively replicating gut bacteria identified by 5-ethynyl-2'-deoxyuridine (EdU) click chemistry and cell sorting.	Beauchemin ET, Hunter C, Maurice CF.	Gut Microbes	10.1080/19490976.2023.2180317	2023
Pathogenicity	Akkermansia muciniphila promotes type H vessel formation and bone fracture healing by reducing gut permeability and inflammation.	Liu JH, Yue T, Luo ZW, Cao J, Yan ZQ, Jin L, Wan TF, Shuai CJ, Wang ZG, Zhou Y, Xu R, Xie H.	Dis Model Mech	10.1242/dmm.043620	2020
Pathogenicity	Wild blueberry proanthocyanidins shape distinct gut microbiota profile and influence glucose homeostasis and intestinal phenotypes in high-fat high-sucrose fed mice.	Rodriguez-Daza MC, Daoust L, Boutkrabt L, Pilon G, Varin T, Dudonne S, Levy E, Marette A, Roy D, Desjardins Y.	Sci Rep	10.1038/s41598-020-58863-1	2020
	The microbiome in inflammatory bowel diseases: from pathogenesis to therapy.	Liu S, Zhao W, Lan P, Mou X.	Protein Cell	10.1007/s13238-020-00745-3	2021
	Recognizing the Benefits of Pre-/Probiotics in Metabolic Syndrome and Type 2 Diabetes Mellitus Considering the Influence of Akkermansia muciniphila as a Key Gut Bacterium.	Corb Aron RA, Abid A, Vesa CM, Nechifor AC, Behl T, Ghitea TC, Munteanu MA, Fratila O, Andronie-Cioara FL, Toma MM, Bungau S.	Microorganisms	10.3390/microorganisms9030618	2021
	Update of the list of QPS-recommended biological agents intentionally added to food or feed as notified to EFSA 12: suitability of taxonomic units notified to EFSA until March 2020.	EFSA Panel on Biological Hazards (BIOHAZ), Koutsoumanis K, Allende A, Alvarez-Ordonez A, Bolton D, Bover-Cid S, Chemaly M, Davies R, De Cesare A, Hilbert F, Lindqvist R, Nauta M, Peixe L, Ru G, Simmons M, Skandamis P, Suffredini E, Cocconcelli PS, Fernandez Escamez PS, Maradona MP, Querol A, Suarez JE, Sundh I, Vlak J, Barizzone F, Hempen M, Herman L.	EFSA J	10.2903/j.efsa.2020.6174	2020
Enzymology	2-oxoglutarate:acceptor oxidoreductase-catalyzed redox cycling effectively targets coccoid forms of Helicobacter pylori.	Hang X, Lan W, Yanqiang H, Huang H, Zhang M, Zeng L, Shi T, Bai Y, Yang Z, Hu S, Wang J, Dong L, Tong Q, Jia J, Bi S, Xia Q, Gao Y, Bi H.	Nat Commun	10.1038/s41467-025-62477-4	2025
	A Computational Framework for Studying Gut-Brain Axis in Autism Spectrum Disorder.	Mohammad FK, Palukuri MV, Shivakumar S, Rengaswamy R, Sahoo S.	Front Physiol	10.3389/fphys.2022.760753	2022
	Beneficial effect of the short-chain fatty acid propionate on vascular calcification through intestinal microbiota remodelling.	Yan J, Pan Y, Shao W, Wang C, Wang R, He Y, Zhang M, Wang Y, Li T, Wang Z, Liu W, Wang Z, Sun X, Dong S.	Microbiome	10.1186/s40168-022-01390-0	2022
	Role of Postbiotics in Diabetes Mellitus: Current Knowledge and Future Perspectives.	Cabello-Olmo M, Arana M, Urtasun R, Encio IJ, Barajas M.	Foods	10.3390/foods10071590	2021
	A new Illumina MiSeq high-throughput sequencing-based method for evaluating the composition of the Bacteroides community in the intestine using the rpsD gene sequence.	Wang C, Feng S, Xiao Y, Pan M, Zhao J, Zhang H, Zhai Q, Chen W.	Microb Biotechnol	10.1111/1751-7915.13651	2021
Enzymology	Precision modification of the human gut microbiota targeting surface-associated proteins.	Marcos-Fernandez R, Ruiz L, Blanco-Miguez A, Margolles A, Sanchez B.	Sci Rep	10.1038/s41598-020-80187-3	2021
	alpha-L-Fucosidases from an Alpaca Faeces Metagenome: Characterisation of Hydrolytic and Transfucosylation Potential.	Krupinskaite A, Stanislauskiene R, Serapinas P, Rutkiene R, Gasparaviciute R, Meskys R, Stankeviciute J.	Int J Mol Sci	10.3390/ijms25020809	2024
	Gut microbiota suppress feeding induced by palatable foods.	Ousey J, Boktor JC, Mazmanian SK.	Curr Biol	10.1016/j.cub.2022.10.066	2023
	A. muciniphila Supplementation in Mice during Pregnancy and Lactation Affects the Maternal Intestinal Microenvironment.	Qi Y, Yu L, Tian F, Zhao J, Zhang H, Chen W, Zhai Q.	Nutrients	10.3390/nu14020390	2022
	Mucin-Degrading Microbes Release Monosaccharides That Chemoattract Clostridioides difficile and Facilitate Colonization of the Human Intestinal Mucus Layer.	Engevik MA, Engevik AC, Engevik KA, Auchtung JM, Chang-Graham AL, Ruan W, Luna RA, Hyser JM, Spinler JK, Versalovic J.	ACS Infect Dis	10.1021/acsinfecdis.0c00634	2021
Metabolism	Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions.	Chelakkot C, Choi Y, Kim DK, Park HT, Ghim J, Kwon Y, Jeon J, Kim MS, Jee YK, Gho YS, Park HS, Kim YK, Ryu SH.	Exp Mol Med	10.1038/emm.2017.282	2018
Metabolism	Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis.	Fang J, Wang H, Zhou Y, Zhang H, Zhou H, Zhang X.	Exp Mol Med	10.1038/s12276-021-00617-8	2021
Genetics	Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila.	Becken B, Davey L, Middleton DR, Mueller KD, Sharma A, Holmes ZC, Dallow E, Remick B, Barton GM, David LA, McCann JR, Armstrong SC, Malkus P, Valdivia RH.	mBio	10.1128/mbio.00478-21	2021
Metabolism	Interleukin-36 cytokines alter the intestinal microbiome and can protect against obesity and metabolic dysfunction.	Giannoudaki E, Hernandez-Santana YE, Mulfaul K, Doyle SL, Hams E, Fallon PG, Mat A, O'Shea D, Kopf M, Hogan AE, Walsh PT.	Nat Commun	10.1038/s41467-019-11944-w	2019
	A Gram-negative-selective antibiotic that spares the gut microbiome.	Munoz KA, Ulrich RJ, Vasan AK, Sinclair M, Wen PC, Holmes JR, Lee HY, Hung CC, Fields CJ, Tajkhorshid E, Lau GW, Hergenrother PJ.	Nature	10.1038/s41586-024-07502-0	2024
	Evolutionary Insights Into Microbiota Transplantation in Inflammatory Bowel Disease.	Wang X, Zhao J, Feng Y, Feng Z, Ye Y, Liu L, Kang G, Cao X.	Front Cell Infect Microbiol	10.3389/fcimb.2022.916543	2022
	Untargeted Metabolomics Sensitively Differentiates Gut Bacterial Species in Single Culture and Co-Culture Systems.	Zhang S, Zhu J.	ACS Omega	10.1021/acsomega.1c07114	2022
	¹³C-Stable isotope resolved metabolomics uncovers dynamic biochemical landscape of gut microbiome-host organ communications in mice.	Xiao X, Zhou Y, Li X, Jin J, Durham J, Ye Z, Wang Y, Hennig B, Deng P.	Microbiome	10.1186/s40168-024-01808-x	2024
Enzymology	Two distinct gut microbial pathways contribute to meta-organismal production of phenylacetylglutamine with links to cardiovascular disease.	Zhu Y, Dwidar M, Nemet I, Buffa JA, Sangwan N, Li XS, Anderson JT, Romano KA, Fu X, Funabashi M, Wang Z, Keranahalli P, Battle S, Tittle AN, Hajjar AM, Gogonea V, Fischbach MA, DiDonato JA, Hazen SL.	Cell Host Microbe	10.1016/j.chom.2022.11.015	2023
	Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?	Geerlings SY, Kostopoulos I, de Vos WM, Belzer C.	Microorganisms	10.3390/microorganisms6030075	2018
Metabolism	Genome-Scale Model and Omics Analysis of Metabolic Capacities of Akkermansia muciniphila Reveal a Preferential Mucin-Degrading Lifestyle.	Ottman N, Davids M, Suarez-Diez M, Boeren S, Schaap PJ, Martins Dos Santos VAP, Smidt H, Belzer C, de Vos WM.	Appl Environ Microbiol	10.1128/aem.01014-17	2017
Metabolism	Deciphering the trophic interaction between Akkermansia muciniphila and the butyrogenic gut commensal Anaerostipes caccae using a metatranscriptomic approach.	Chia LW, Hornung BVH, Aalvink S, Schaap PJ, de Vos WM, Knol J, Belzer C.	Antonie Van Leeuwenhoek	10.1007/s10482-018-1040-x	2018
Enzymology	Polyphenol-Mediated Gut Microbiota Modulation: Toward Prebiotics and Further.	Rodriguez-Daza MC, Pulido-Mateos EC, Lupien-Meilleur J, Guyonnet D, Desjardins Y, Roy D.	Front Nutr	10.3389/fnut.2021.689456	2021
	Gut microbiota as an antioxidant system in centenarians associated with high antioxidant activities of gut-resident Lactobacillus.	Wu L, Xie X, Li Y, Liang T, Zhong H, Yang L, Xi Y, Zhang J, Ding Y, Wu Q.	NPJ Biofilms Microbiomes	10.1038/s41522-022-00366-0	2022
	Bacterial PncA improves diet-induced NAFLD in mice by enabling the transition from nicotinamide to nicotinic acid.	Feng S, Guo L, Wang H, Yang S, Liu H.	Commun Biol	10.1038/s42003-023-04613-8	2023
Pathogenicity	Grape proanthocyanidin-induced intestinal bloom of Akkermansia muciniphila is dependent on its baseline abundance and precedes activation of host genes related to metabolic health.	Zhang L, Carmody RN, Kalariya HM, Duran RM, Moskal K, Poulev A, Kuhn P, Tveter KM, Turnbaugh PJ, Raskin I, Roopchand DE.	J Nutr Biochem	10.1016/j.jnutbio.2018.02.009	2018
	The microenvironment of injured murine gut elicits a local pro-restitutive microbiota.	Alam A, Leoni G, Quiros M, Wu H, Desai C, Nishio H, Jones RM, Nusrat A, Neish AS.	Nat Microbiol	10.1038/nmicrobiol.2015.21	2016
Genetics	Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.	Rosario D, Benfeitas R, Bidkhori G, Zhang C, Uhlen M, Shoaie S, Mardinoglu A.	Front Physiol	10.3389/fphys.2018.00775	2018
	Safety of Novel Microbes for Human Consumption: Practical Examples of Assessment in the European Union.	Brodmann T, Endo A, Gueimonde M, Vinderola G, Kneifel W, de Vos WM, Salminen S, Gomez-Gallego C.	Front Microbiol	10.3389/fmicb.2017.01725	2017
	THE SMALL INTESTINAL MICROBIOME: VIBING WITH INTESTINAL STEM CELLS.	Poplaski V, Sawyer F, Blutt SE.	Microbiota Host	10.1530/mah-23-0012	2023
	Structure similarity and molecular networking analysis for the discovery of polyphenol biotransformation products of gut microbes.	Xu R, Lee J, Zhang S, Chen L, Zhu J.	Anal Chim Acta	10.1016/j.aca.2022.340145	2022
	Increased GVHD-related mortality with broad-spectrum antibiotic use after allogeneic hematopoietic stem cell transplantation in human patients and mice.	Shono Y, Docampo MD, Peled JU, Perobelli SM, Velardi E, Tsai JJ, Slingerland AE, Smith OM, Young LF, Gupta J, Lieberman SR, Jay HV, Ahr KF, Porosnicu Rodriguez KA, Xu K, Calarfiore M, Poeck H, Caballero S, Devlin SM, Rapaport F, Dudakov JA, Hanash AM, Gyurkocza B, Murphy GF, Gomes C, Liu C, Moss EL, Falconer SB, Bhatt AS, Taur Y, Pamer EG, van den Brink MRM, Jenq RR.	Sci Transl Med	10.1126/scitranslmed.aaf2311	2016
Genetics	A Comparative Analysis of Biosynthetic Gene Clusters in Lean and Obese Humans.	Wang S, Li N, Li N, Zou H, Wu M.	Biomed Res Int	10.1155/2019/6361320	2019
Pathogenicity	Triggering Akkermansia with dietary polyphenols: A new weapon to combat the metabolic syndrome?	Anhe FF, Pilon G, Roy D, Desjardins Y, Levy E, Marette A.	Gut Microbes	10.1080/19490976.2016.1142036	2016
	Increasing breast milk betaine modulates Akkermansia abundance in mammalian neonates and improves long-term metabolic health.	Ribo S, Sanchez-Infantes D, Martinez-Guino L, Garcia-Mantrana I, Ramon-Krauel M, Tondo M, Arning E, Nofrarias M, Osorio-Conles O, Fernandez-Perez A, Gonzalez-Torres P, Cebria J, Gavalda-Navarro A, Chenoll E, Isganaitis E, Villarroya F, Vallejo M, Segales J, Jimenez-Chillaron JC, Bottiglieri T, Demerath EW, Fields DA, Collado MC, Lerin C.	Sci Transl Med	10.1126/scitranslmed.abb0322	2021
Metabolism	The genome of Akkermansia muciniphila, a dedicated intestinal mucin degrader, and its use in exploring intestinal metagenomes.	van Passel MW, Kant R, Zoetendal EG, Plugge CM, Derrien M, Malfatti SA, Chain PS, Woyke T, Palva A, de Vos WM, Smidt H.	PLoS One	10.1371/journal.pone.0016876	2011
	Intelectin-1 binds and alters the localization of the mucus barrier-modifying bacterium Akkermansia muciniphila.	Matute JD, Duan J, Flak MB, Griebel P, Tascon-Arcila JA, Doms S, Hanley T, Antanaviciute A, Gundrum J, Mark Welch JL, Sit B, Abtahi S, Fuhler GM, Grootjans J, Tran F, Stengel ST, White JR, Krupka N, Haller D, Clare S, Lawley TD, Kaser A, Simmons A, Glickman JN, Bry L, Rosenstiel P, Borisy G, Waldor MK, Baines JF, Turner JR, Blumberg RS.	J Exp Med	10.1084/jem.20211938	2023
	Host Age Prediction from Fecal Microbiota Composition in Male C57BL/6J Mice.	Low A, Soh M, Miyake S, Seedorf H.	Microbiol Spectr	10.1128/spectrum.00735-22	2022
	The gut microbiome of laboratory mice: considerations and best practices for translational research.	Ericsson AC, Franklin CL.	Mamm Genome	10.1007/s00335-021-09863-7	2021
	Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice.	Xu YL, Ding CL, Qian CL, Qi ZT, Wang W.	Cell Death Dis	10.1038/s41419-019-2186-9	2019
	Culturing of a complex gut microbial community in mucin-hydrogel carriers reveals strain- and gene-associated spatial organization.	Jin X, Yu FB, Yan J, Weakley AM, Dubinkina V, Meng X, Pollard KS.	Nat Commun	10.1038/s41467-023-39121-0	2023
	A Soybean Resistant Protein-Containing Diet Increased the Production of Reg3gamma Through the Regulation of the Gut Microbiota and Enhanced the Intestinal Barrier Function in Mice.	Ogita T, Namai F, Mikami A, Ishiguro T, Umezawa K, Uyeno Y, Shimosato T.	Front Nutr	10.3389/fnut.2021.701466	2021
	Exploring the sequence-function space of microbial fucosidases.	Martinez Gascuena A, Wu H, Wang R, Owen CD, Hernando PJ, Monaco S, Penner M, Xing K, Le Gall G, Gardner R, Ndeh D, Urbanowicz PA, Spencer DIR, Walsh M, Angulo J, Juge N.	Commun Chem	10.1038/s42004-024-01212-4	2024
	Evolution of endonuclease IV protein family: an in silico analysis.	Kanchan S, Sharma P, Chowdhury S.	3 Biotech	10.1007/s13205-019-1696-6	2019
Genetics	Reconstruction of Bacterial and Viral Genomes from Multiple Metagenomes.	Gupta A, Kumar S, Prasoodanan VP, Harish K, Sharma AK, Sharma VK.	Front Microbiol	10.3389/fmicb.2016.00469	2016
Metabolism	Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength.	Liu JH, Chen CY, Liu ZZ, Luo ZW, Rao SS, Jin L, Wan TF, Yue T, Tan YJ, Yin H, Yang F, Huang FY, Guo J, Wang YY, Xia K, Cao J, Wang ZX, Hong CG, Luo MJ, Hu XK, Liu YW, Du W, Luo J, Hu Y, Zhang Y, Huang J, Li HM, Wu B, Liu HM, Chen TH, Qian YX, Li YY, Feng SK, Chen Y, Qi LY, Xu R, Tang SY, Xie H.	Adv Sci (Weinh)	10.1002/advs.202004831	2021
Metabolism	Lactobacillus rhamnosus GG Derived Extracellular Vesicles Modulate Gut Microbiota and Attenuate Inflammatory in DSS-Induced Colitis Mice.	Tong L, Zhang X, Hao H, Liu Q, Zhou Z, Liang X, Liu T, Gong P, Zhang L, Zhai Z, Hao Y, Yi H.	Nutrients	10.3390/nu13103319	2021
Pathogenicity	Polyphenol- and Caffeine-Rich Postfermented Pu-erh Tea Improves Diet-Induced Metabolic Syndrome by Remodeling Intestinal Homeostasis in Mice.	Gao X, Xie Q, Kong P, Liu L, Sun S, Xiong B, Huang B, Yan L, Sheng J, Xiang H.	Infect Immun	10.1128/iai.00601-17	2018
Metabolism	Akkermansia muciniphila mediates negative effects of IFNgamma on glucose metabolism.	Greer RL, Dong X, Moraes AC, Zielke RA, Fernandes GR, Peremyslova E, Vasquez-Perez S, Schoenborn AA, Gomes EP, Pereira AC, Ferreira SR, Yao M, Fuss IJ, Strober W, Sikora AE, Taylor GA, Gulati AS, Morgun A, Shulzhenko N.	Nat Commun	10.1038/ncomms13329	2016
Metabolism	Identification of Allobaculum mucolyticum as a novel human intestinal mucin degrader.	van Muijlwijk GH, van Mierlo G, Jansen PWTC, Vermeulen M, Bleumink-Pluym NMC, Palm NW, van Putten JPM, de Zoete MR.	Gut Microbes	10.1080/19490976.2021.1966278	2021
	Berry Polyphenols and Fibers Modulate Distinct Microbial Metabolic Functions and Gut Microbiota Enterotype-Like Clustering in Obese Mice.	Rodriguez-Daza MC, Roquim M, Dudonne S, Pilon G, Levy E, Marette A, Roy D, Desjardins Y.	Front Microbiol	10.3389/fmicb.2020.02032	2020
	A decrease in functional microbiomes represented as Faecalibacterium affects immune homeostasis in long-term stable liver transplant patients.	Lee SK, Jhun J, Lee SY, Choi S, Choi SS, Park MS, Lee SY, Cho KH, Lee AR, Ahn J, Choi HJ, You YK, Sung PS, Jang JW, Bae SH, Yoon SK, Cho ML, Choi JY.	Gut Microbes	10.1080/19490976.2022.2102885	2022
	Altered microbiota associated with abnormal humoral immune responses to commensal organisms in enthesitis-related arthritis.	Stoll ML, Kumar R, Morrow CD, Lefkowitz EJ, Cui X, Genin A, Cron RQ, Elson CO.	Arthritis Res Ther	10.1186/s13075-014-0486-0	2014
	Commensal epitopes drive differentiation of colonic T_regs.	Kuczma MP, Szurek EA, Cebula A, Chassaing B, Jung YJ, Kang SM, Fox JG, Stecher B, Ignatowicz L.	Sci Adv	10.1126/sciadv.aaz3186	2020
	Deep-learning-enabled antibiotic discovery through molecular de-extinction.	Wan F, Torres MDT, Peng J, de la Fuente-Nunez C.	Nat Biomed Eng	10.1038/s41551-024-01201-x	2024
Enzymology	Kinetics and structural features of dimeric glutamine-dependent bacterial NAD⁺ synthetases suggest evolutionary adaptation to available metabolites.	Santos ARS, Gerhardt ECM, Moure VR, Pedrosa FO, Souza EM, Diamanti R, Hogbom M, Huergo LF.	J Biol Chem	10.1074/jbc.ra118.002241	2018
Metabolism	Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis.	Kang CS, Ban M, Choi EJ, Moon HG, Jeon JS, Kim DK, Park SK, Jeon SG, Roh TY, Myung SJ, Gho YS, Kim JG, Kim YK.	PLoS One	10.1371/journal.pone.0076520	2013
	Genetic and environmental control of host-gut microbiota interactions.	Org E, Org E, Parks BW, Joo JW, Emert B, Schwartzman W, Kang EY, Mehrabian M, Pan C, Knight R, Gunsalus R, Drake TA, Eskin E, Lusis AJ.	Genome Res	10.1101/gr.194118.115	2015
Metabolism	Distribution of glucan-branching enzymes among prokaryotes.	Suzuki E, Suzuki R.	Cell Mol Life Sci	10.1007/s00018-016-2243-9	2016
	Single-strain behavior predicts responses to environmental pH and osmolality in the gut microbiota.	Ng KM, Pannu S, Liu S, Burckhardt JC, Hughes T, Van Treuren W, Nguyen J, Naqvi K, Nguyen B, Clayton CA, Pepin DM, Collins SR, Tropini C.	mBio	10.1128/mbio.00753-23	2023
	Prospects of Probiotic Adjuvant Drugs in Clinical Treatment.	Ren Z, Hong Y, Huo Y, Peng L, Lv H, Chen J, Wu Z, Wan C.	Nutrients	10.3390/nu14224723	2022
	SARS-CoV-2-specific T cells in unexposed adults display broad trafficking potential and cross-react with commensal antigens.	Bartolo L, Afroz S, Pan YG, Xu R, Williams L, Lin CF, Tanes C, Bittinger K, Friedman ES, Gimotty PA, Wu GD, Su LF.	Sci Immunol	10.1126/sciimmunol.abn3127	2022
	Intracellular Fusobacterium nucleatum infection attenuates antitumor immunity in esophageal squamous cell carcinoma.	Li Y, Xing S, Chen F, Li Q, Dou S, Huang Y, An J, Liu W, Zhang G.	Nat Commun	10.1038/s41467-023-40987-3	2023
Enzymology	A reverse metabolic approach to weaning: in silico identification of immune-beneficial infant gut bacteria, mining their metabolism for prebiotic feeds and sourcing these feeds in the natural product space.	Michelini S, Balakrishnan B, Parolo S, Matone A, Mullaney JA, Young W, Gasser O, Wall C, Priami C, Lombardo R, Kussmann M.	Microbiome	10.1186/s40168-018-0545-x	2018
Enzymology	Comparison of bacterial quantities in left and right colon biopsies and faeces.	Lyra A, Forssten S, Rolny P, Wettergren Y, Lahtinen SJ, Salli K, Cedgard L, Odin E, Gustavsson B, Ouwehand AC.	World J Gastroenterol	10.3748/wjg.v18.i32.4404	2012
	Dietary Polyphenols Promote Growth of the Gut Bacterium Akkermansia muciniphila and Attenuate High-Fat Diet-Induced Metabolic Syndrome.	Roopchand DE, Carmody RN, Kuhn P, Moskal K, Rojas-Silva P, Turnbaugh PJ, Raskin I.	Diabetes	10.2337/db14-1916	2015
Metabolism	Strain dropouts reveal interactions that govern the metabolic output of the gut microbiome.	Wang M, Osborn LJ, Jain S, Meng X, Weakley A, Yan J, Massey WJ, Varadharajan V, Horak A, Banerjee R, Allende DS, Chan ER, Hajjar AM, Wang Z, Dimas A, Zhao A, Nagashima K, Cheng AG, Higginbottom S, Hazen SL, Brown JM, Fischbach MA.	Cell	10.1016/j.cell.2023.05.037	2023
Genetics	Strain/species identification in metagenomes using genome-specific markers.	Tu Q, He Z, Zhou J.	Nucleic Acids Res	10.1093/nar/gku138	2014
	Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.	Engevik MA, Morra CN, Roth D, Engevik K, Spinler JK, Devaraj S, Crawford SE, Estes MK, Kalkum M, Versalovic J.	Front Microbiol	10.3389/fmicb.2019.02305	2019
	Mechanistic Insights Into the Cross-Feeding of Ruminococcus gnavus and Ruminococcus bromii on Host and Dietary Carbohydrates.	Crost EH, Le Gall G, Laverde-Gomez JA, Mukhopadhya I, Flint HJ, Juge N.	Front Microbiol	10.3389/fmicb.2018.02558	2018
Metabolism	Intestinal integrity and Akkermansia muciniphila, a mucin-degrading member of the intestinal microbiota present in infants, adults, and the elderly.	Collado MC, Derrien M, Isolauri E, de Vos WM, Salminen S.	Appl Environ Microbiol	10.1128/aem.01477-07	2007
	Commensal Akkermansia muciniphila exacerbates gut inflammation in Salmonella Typhimurium-infected gnotobiotic mice.	Ganesh BP, Klopfleisch R, Loh G, Blaut M.	PLoS One	10.1371/journal.pone.0074963	2013
	The prevalence of species and strains in the human microbiome: a resource for experimental efforts.	Kraal L, Abubucker S, Kota K, Fischbach MA, Mitreva M.	PLoS One	10.1371/journal.pone.0097279	2014
	Mucin glycan foraging in the human gut microbiome.	Tailford LE, Crost EH, Kavanaugh D, Juge N.	Front Genet	10.3389/fgene.2015.00081	2015
	Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus.	Lv W, Graves DT, He L, Shi Y, Deng X, Zhao Y, Dong X, Ren Y, Liu X, Xiao E, Zhang Y.	Theranostics	10.7150/thno.44113	2020
	Veillonella, Firmicutes: Microbes disguised as Gram negatives.	Vesth T, Ozen A, Andersen SC, Kaas RS, Lukjancenko O, Bohlin J, Nookaew I, Wassenaar TM, Ussery DW.	Stand Genomic Sci	10.4056/sigs.2981345	2013
Pathogenicity	Enterococcus faecalis Sex Pheromone cCF10 Enhances Conjugative Plasmid Transfer In Vivo.	Hirt H, Greenwood-Quaintance KE, Karau MJ, Till LM, Kashyap PC, Patel R, Dunny GM.	mBio	10.1128/mbio.00037-18	2018
	Methionine restriction-induced sulfur deficiency impairs antitumour immunity partially through gut microbiota.	Ji M, Xu X, Xu Q, Hsiao YC, Martin C, Ukraintseva S, Popov V, Arbeev KG, Randall TA, Wu X, Garcia-Peterson LM, Liu J, Xu X, Andrea Azcarate-Peril M, Wan Y, Yashin AI, Anantharaman K, Lu K, Li JL, Shats I, Li X.	Nat Metab	10.1038/s42255-023-00854-3	2023
	Host-compound foraging by intestinal microbiota revealed by single-cell stable isotope probing.	Berry D, Stecher B, Schintlmeister A, Reichert J, Brugiroux S, Wild B, Wanek W, Richter A, Rauch I, Decker T, Loy A, Wagner M.	Proc Natl Acad Sci U S A	10.1073/pnas.1219247110	2013
Genetics	Functional metagenomics reveals novel salt tolerance loci from the human gut microbiome.	Culligan EP, Sleator RD, Marchesi JR, Hill C.	ISME J	10.1038/ismej.2012.38	2012
	Dynamic Modulation of the Gut Microbiota and Metabolome by Bacteriophages in a Mouse Model.	Hsu BB, Gibson TE, Yeliseyev V, Liu Q, Lyon L, Bry L, Silver PA, Gerber GK.	Cell Host Microbe	10.1016/j.chom.2019.05.001	2019
	Design, construction, and in vivo augmentation of a complex gut microbiome.	Cheng AG, Ho PY, Aranda-Diaz A, Jain S, Yu FB, Meng X, Wang M, Iakiviak M, Nagashima K, Zhao A, Murugkar P, Patil A, Atabakhsh K, Weakley A, Yan J, Brumbaugh AR, Higginbottom S, Dimas A, Shiver AL, Deutschbauer A, Neff N, Sonnenburg JL, Huang KC, Fischbach MA.	Cell	10.1016/j.cell.2022.08.003	2022
	Peptidoglycan: a post-genomic analysis.	Cayrou C, Henrissat B, Gouret P, Pontarotti P, Drancourt M.	BMC Microbiol	10.1186/1471-2180-12-294	2012
	A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome.	Jaja-Chimedza A, Zhang L, Wolff K, Graf BL, Kuhn P, Moskal K, Carmouche R, Newman S, Salbaum JM, Raskin I.	J Funct Foods	10.1016/j.jff.2018.05.056	2018
Genetics	Analysis of genome content evolution in pvc bacterial super-phylum: assessment of candidate genes associated with cellular organization and lifestyle.	Kamneva OK, Knight SJ, Liberles DA, Ward NL.	Genome Biol Evol	10.1093/gbe/evs113	2012
Metabolism	Comparative analysis of the extracellular proteomes of two Clostridium sordellii strains exhibiting contrasting virulence.	Kachman MT, Hurley MC, Thiele T, Srinivas G, Aronoff DM.	Anaerobe	10.1016/j.anaerobe.2010.03.004	2010
	Metagenomic profiling of known and unknown microbes with microbeGPS.	Lindner MS, Renard BY.	PLoS One	10.1371/journal.pone.0117711	2015
Genetics	Environmental Metagenomic Assemblies Reveal Seven New Highly Divergent Chlamydial Lineages and Hallmarks of a Conserved Intracellular Lifestyle.	Pillonel T, Bertelli C, Greub G.	Front Microbiol	10.3389/fmicb.2018.00079	2018
Phylogeny	Combining 16S rRNA gene variable regions enables high-resolution microbial community profiling.	Fuks G, Elgart M, Amir A, Zeisel A, Turnbaugh PJ, Soen Y, Shental N.	Microbiome	10.1186/s40168-017-0396-x	2018
	The Glutaminase-Dependent Acid Resistance System: Qualitative and Quantitative Assays and Analysis of Its Distribution in Enteric Bacteria.	Pennacchietti E, D'Alonzo C, Freddi L, Occhialini A, De Biase D.	Front Microbiol	10.3389/fmicb.2018.02869	2018
	BacArena: Individual-based metabolic modeling of heterogeneous microbes in complex communities.	Bauer E, Zimmermann J, Baldini F, Thiele I, Kaleta C.	PLoS Comput Biol	10.1371/journal.pcbi.1005544	2017
Genetics	DciA is an ancestral replicative helicase operator essential for bacterial replication initiation.	Brezellec P, Vallet-Gely I, Possoz C, Quevillon-Cheruel S, Ferat JL.	Nat Commun	10.1038/ncomms13271	2016
Pathogenicity	Probiotic and commensal gut microbial therapies in multiple sclerosis and its animal models: a comprehensive review.	Blais LL, Montgomery TL, Amiel E, Deming PB, Krementsov DN.	Gut Microbes	10.1080/19490976.2021.1943289	2021
Metabolism	Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis.	Kwon YH, Wang H, Denou E, Ghia JE, Rossi L, Fontes ME, Bernier SP, Shajib MS, Banskota S, Collins SM, Surette MG, Khan WI.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2019.01.004	2019
	Assessing Bacterial Interactions Using Carbohydrate-Based Microarrays.	Flannery A, Gerlach JQ, Joshi L, Kilcoyne M.	Microarrays (Basel)	10.3390/microarrays4040690	2015
Genetics	Assessment of k-mer spectrum applicability for metagenomic dissimilarity analysis.	Dubinkina VB, Ischenko DS, Ulyantsev VI, Tyakht AV, Alexeev DG.	BMC Bioinformatics	10.1186/s12859-015-0875-7	2016
	A novel extracellular metallopeptidase domain shared by animal host-associated mutualistic and pathogenic microbes.	Nakjang S, Ndeh DA, Wipat A, Bolam DN, Hirt RP.	PLoS One	10.1371/journal.pone.0030287	2012
Pathogenicity	Dietary Fructose Alters the Composition, Localization, and Metabolism of Gut Microbiota in Association With Worsening Colitis.	Montrose DC, Nishiguchi R, Basu S, Staab HA, Zhou XK, Wang H, Meng L, Johncilla M, Cubillos-Ruiz JR, Morales DK, Wells MT, Simpson KW, Zhang S, Dogan B, Jiao C, Fei Z, Oka A, Herzog JW, Sartor RB, Dannenberg AJ.	Cell Mol Gastroenterol Hepatol	10.1016/j.jcmgh.2020.09.008	2021
Metabolism	Reshaping of bacterial molecular hydrogen metabolism contributes to the outgrowth of commensal E. coli during gut inflammation.	Hughes ER, Winter MG, Alves da Silva L, Muramatsu MK, Jimenez AG, Gillis CC, Spiga L, Chanin RB, Santos RL, Zhu W, Winter SE.	Elife	10.7554/elife.58609	2021
	Dissemination of 6S RNA among bacteria.	Wehner S, Damm K, Hartmann RK, Marz M.	RNA Biol	10.4161/rna.29894	2014
Phylogeny	The human gut chip "HuGChip", an explorative phylogenetic microarray for determining gut microbiome diversity at family level.	Tottey W, Denonfoux J, Jaziri F, Parisot N, Missaoui M, Hill D, Borrel G, Peyretaillade E, Alric M, Harris HM, Jeffery IB, Claesson MJ, O'Toole PW, Peyret P, Brugere JF.	PLoS One	10.1371/journal.pone.0062544	2013
	Intestinal microbiota as modulators of the immune system and neuroimmune system: impact on the host health and homeostasis.	Maranduba CM, De Castro SB, de Souza GT, Rossato C, da Guia FC, Valente MA, Rettore JV, Maranduba CP, de Souza CM, do Carmo AM, Macedo GC, Silva Fde S.	J Immunol Res	10.1155/2015/931574	2015
Metabolism	Capturing single cell genomes of active polysaccharide degraders: an unexpected contribution of Verrucomicrobia.	Martinez-Garcia M, Brazel DM, Swan BK, Arnosti C, Chain PS, Reitenga KG, Xie G, Poulton NJ, Lluesma Gomez M, Masland DE, Thompson B, Bellows WK, Ziervogel K, Lo CC, Ahmed S, Gleasner CD, Detter CJ, Stepanauskas R.	PLoS One	10.1371/journal.pone.0035314	2012
	Deciphering interactions between the gut microbiota and the immune system via microbial cultivation and minimal microbiomes.	Clavel T, Gomes-Neto JC, Lagkouvardos I, Ramer-Tait AE.	Immunol Rev	10.1111/imr.12578	2017
Genetics	A comprehensive benchmarking study of protocols and sequencing platforms for 16S rRNA community profiling.	D'Amore R, Ijaz UZ, Schirmer M, Kenny JG, Gregory R, Darby AC, Shakya M, Podar M, Quince C, Hall N.	BMC Genomics	10.1186/s12864-015-2194-9	2016
Enzymology	Complete genome sequence of the extremely acidophilic methanotroph isolate V4, Methylacidiphilum infernorum, a representative of the bacterial phylum Verrucomicrobia.	Hou S, Makarova KS, Saw JH, Senin P, Ly BV, Zhou Z, Ren Y, Wang J, Galperin MY, Omelchenko MV, Wolf YI, Yutin N, Koonin EV, Stott MB, Mountain BW, Crowe MA, Smirnova AV, Dunfield PF, Feng L, Wang L, Alam M.	Biol Direct	10.1186/1745-6150-3-26	2008
Phylogeny	Genome-Resolved Metagenomics Extends the Environmental Distribution of the Verrucomicrobia Phylum to the Deep Terrestrial Subsurface.	Nixon SL, Daly RA, Borton MA, Solden LM, Welch SA, Cole DR, Mouser PJ, Wilkins MJ, Wrighton KC.	mSphere	10.1128/msphere.00613-19	2019
	Noncellulosomal cohesin- and dockerin-like modules in the three domains of life.	Peer A, Smith SP, Bayer EA, Lamed R, Borovok I.	FEMS Microbiol Lett	10.1111/j.1574-6968.2008.01420.x	2009
	Bambus 2: scaffolding metagenomes.	Koren S, Treangen TJ, Pop M.	Bioinformatics	10.1093/bioinformatics/btr520	2011
	Comprehensive prediction of chromosome dimer resolution sites in bacterial genomes.	Kono N, Arakawa K, Tomita M.	BMC Genomics	10.1186/1471-2164-12-19	2011
	Ecophysiology of Freshwater Verrucomicrobia Inferred from Metagenome-Assembled Genomes.	He S, Stevens SLR, Chan LK, Bertilsson S, Glavina Del Rio T, Tringe SG, Malmstrom RR, McMahon KD.	mSphere	10.1128/msphere.00277-17	2017
Genetics	Information theoretic perspective on genome clustering.	Veluchamy A, Mehta P, Srividhya KV, Vikram H, Govind MK, Gupta R, Aziz Bin Dukhyil A, Abdullah Alharbi R, Abdullah Aloyuni S, Hassan MM, Krishnaswamy S.	Saudi J Biol Sci	10.1016/j.sjbs.2020.12.039	2021
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
	Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family.	Silverio AL, Saier MH.	J Membr Biol	10.1007/s00232-011-9364-8	2011
	Next Generation Probiotics for Neutralizing Obesogenic Effects: Taxa Culturing Searching Strategies.	Lopez-Moreno A, Acuna I, Torres-Sanchez A, Ruiz-Moreno A, Cerk K, Rivas A, Suarez A, Monteoliva-Sanchez M, Aguilera M.	Nutrients	10.3390/nu13051617	2021
	Different Intestinal Microbial Profile in Over-Weight and Obese Subjects Consuming a Diet with Low Content of Fiber and Antioxidants.	Fernandez-Navarro T, Salazar N, Gutierrez-Diaz I, de Los Reyes-Gavilan CG, Gueimonde M, Gonzalez S.	Nutrients	10.3390/nu9060551	2017
Metabolism	Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls.	Sundin J, Rangel I, Repsilber D, Brummer RJ.	PLoS One	10.1371/journal.pone.0134836	2015
	Identification of herbal drug extracts that promote growth of Akkermansia muciniphila in high-fat diet fed mice.	Fujisaka S, Watanabe Y, Toume K, Morinaga Y, Nawaz A, Kado T, Nishimura A, Bilal M, Aslam MR, Igarashi Y, Nakagawa Y, Tobe K.	Diabetol Int	10.1007/s13340-024-00713-w	2024
	Metabolite-mediated interactions and direct contact between Fusobacterium varium and Faecalibacterium prausnitzii.	Hosomi K, Maruyama S, Matsuoka T, Furuta M, Tojima Y, Uchiyama K, Morita M, Kawashima H, Kobayashi T, Kunisawa J.	Microbiome	10.1186/s40168-025-02168-w	2025
Metabolism	Akkermansia muciniphila and environmental enrichment reverse cognitive impairment associated with high-fat high-cholesterol consumption in rats.	Higarza SG, Arboleya S, Arias JL, Gueimonde M, Arias N	Gut Microbes	10.1080/19490976.2021.1880240	2021
	Preliminary Evaluation of the Safety and Probiotic Potential of Akkermansia muciniphila DSM 22959 in Comparison with Lactobacillus rhamnosus GG.	Cozzolino A, Vergalito F, Tremonte P, Iorizzo M, Lombardi SJ, Sorrentino E, Luongo D, Coppola R, Di Marco R, Succi M	Microorganisms	10.3390/microorganisms8020189	2020
Metabolism	Viability of microencapsulated Akkermansia muciniphila and Lactobacillus plantarum during freeze-drying, storage and in vitro simulated upper gastrointestinal tract passage.	Marcial-Coba MS, Cieplak T, Cahu TB, Blennow A, Knochel S, Nielsen DS	Food Funct	10.1039/c8fo01331d	2018
	Spray-Drying Encapsulation of the Live Biotherapeutic Candidate Akkermansia muciniphila DSM 22959 to Survive Aerobic Storage.	Barbosa JC, Almeida D, Machado D, Sousa S, Freitas AC, Andrade JC, Gomes AM	Pharmaceuticals (Basel)	10.3390/ph15050628	2022
Pathogenicity	Characterization of antibiotic-resistance traits in Akkermansia muciniphila strains of human origin.	Filardi R, Gargari G, Mora D, Arioli S	Sci Rep	10.1038/s41598-022-23980-6	2022
Phylogeny	Insights into the Antimicrobial Resistance Profile of a Next Generation Probiotic Akkermansia muciniphila DSM 22959.	Machado D, Barbosa JC, Almeida D, Andrade JC, Freitas AC, Gomes AM	Int J Environ Res Public Health	10.3390/ijerph19159152	2022
Metabolism	Genome analysis and 2'-fucosyllactose utilization characteristics of a new Akkermansia muciniphila strain isolated from mice feces.	Gao W, Xiao M, Gu Z, Fu X, Ren X, Yu Y, Liu Z, Zhu C, Kong Q, Mou H	Mol Genet Genomics	10.1007/s00438-022-01937-8	2022
	Akkermansia beyond muciniphila - emergence of new species Akkermansia massiliensis sp. nov.	Kumar R, Hasselwander O, Kane H, Hibberd AA.	Microbiome Res Rep	10.20517/mrr.2024.28	2024
	Reclassification of eight Akkermansia muciniphila strains and description of Akkermansia massiliensis sp. nov. and Candidatus Akkermansia timonensis, isolated from human feces.	Ndongo S, Armstrong N, Raoult D, Fournier PE.	Sci Rep	10.1038/s41598-022-25873-0	2022
	Safety evaluation of Akkermansia massiliensis sp. nov. DSM 33459.	Pitt J, Bauter MR, Kumar R, Hasselwander O, Hibberd AA, Kane H, Wang Q, Auzanneau I, Bry S, David E, Seguinot P, Burns F, Smith AB.	Toxicol Rep	10.1016/j.toxrep.2025.102042	2025
Phylogeny	Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium.	Derrien M, Vaughan EE, Plugge CM, de Vos WM	Int J Syst Evol Microbiol	10.1099/ijs.0.02873-0	2004

References

#16637	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 22959
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
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#63059	Culture Collection University of Gothenburg (CCUG) ; Curators of the CCUG; CCUG 64013
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
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#68380	Automatically annotated from API rID32A .
#68382	Automatically annotated from API zym .
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Akkermansia muciniphila (DSM 22959, ATCC BAA-835, CIP 107961)

Name and taxonomic classification

Morphology

Cell morphology

Colony morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

Metabolite production

Metabolite tests

Enzymes

API zym

API rID32A

Isolation, sampling and environmental information

Isolation source categories

Isolation

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_017504145

16S sequences

GC content

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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