Catenulispora acidiphila (DSM 44928, NRRL B-24433, ID 139908)

Cell morphology

Pigmentation

Multimedia

• @ref:	12201
  multimedia content:	DSM_44928.jpg
  multimedia.multimedia content:	https://www.dsmz.de/microorganisms/photos/DSM_44928.jpg
  caption:	Medium 65 pH5.5 28°C
  intellectual property rights:	© Leibniz-Institut DSMZ
  manual_annotation:	1

• @ref:	66793
  multimedia content:	EM_DSM_44928_1.jpg
  multimedia.multimedia content:	EM_DSM_44928_1.jpg
  caption:	electron microscopic image
  intellectual property rights:	© HZI/Manfred Rohde
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
12201	GYM STREPTOMYCES MEDIUM (DSMZ Medium 65)		Medium recipe at MediaDive	Name: GYM STREPTOMYCES MEDIUM (DSMZ Medium 65) Composition: Agar 18.0 g/l Malt extract 10.0 g/l Yeast extract 4.0 g/l Glucose 4.0 g/l CaCO3 2.0 g/l Distilled water
12201	ISP2 MEDIUM (DSMZ Medium 987)		Medium recipe at MediaDive	Name: ISP 2 MEDIUM (DSMZ Medium 987) Composition: Agar 20.0 g/l Malt extract 10.0 g/l Dextrose 4.0 g/l Yeast extract 4.0 g/l Distilled water
33295	MEDIUM 688 for Catenulispora acidiphila
116002	CIP Medium 688		Medium recipe at CIP
12201	ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84)		Medium recipe at MediaDive	Name: ROLLED OATS MINERAL MEDIUM (DSMZ Medium 84) Composition: Agar 20.0 g/l Rolled oats 20.0 g/l ZnSO4 x 7 H2O 0.001 g/l MnCl2 x 4 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Distilled water

Culture temp

Culture pH

Oxygen tolerance

Spore formation

Halophily

Observation

Tolerance

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
31588	22599 ChEBI	arabinose	+	carbon source
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
27877		casein	+	hydrolysis
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
27877	62968 ChEBI	cellulose	-	assimilation
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	+	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	+	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	+	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
31588	28757 ChEBI	fructose	+	carbon source
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
27877	5291 ChEBI	gelatin	+	hydrolysis
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
31588	17234 ChEBI	glucose	+	carbon source
31588	17754 ChEBI	glycerol	+	carbon source
68371	17754 ChEBI	glycerol	+	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	+	builds acid from	from API 50CH acid
31588	29864 ChEBI	mannitol	+	carbon source
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
27877	17268 ChEBI	myo-inositol	-	assimilation
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
27877	17632 ChEBI	nitrate	-	reduction
116002	17632 ChEBI	nitrate	-	reduction
116002	16301 ChEBI	nitrite	-	reduction
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	+	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
27877	26546 ChEBI	rhamnose	-	assimilation
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
27877	28017 ChEBI	starch	+	hydrolysis
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
27877	17992 ChEBI	sucrose	-	assimilation
68371	17992 ChEBI	sucrose	+	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid
31588	18222 ChEBI	xylose	+	carbon source

Antibiotic resistance

Metabolite production

@ref	Chebi-ID	Metabolite	Production
31588	16136 ChEBI	hydrogen sulfide
116002	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	beta-glucosidase	-	3.2.1.21	from API zym
31588	catalase	+	1.11.1.6
116002	catalase	+	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	naphthol-AS-BI-phosphohydrolase	+		from API zym
116002	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
116002	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	aspartate and asparagine metabolism	100	9 of 9
66794	starch degradation	100	10 of 10
66794	phenylacetate degradation (aerobic)	100	5 of 5
66794	biotin biosynthesis	100	4 of 4
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	octane oxidation	100	3 of 3
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	propanol degradation	100	7 of 7
66794	molybdenum cofactor biosynthesis	100	9 of 9
66794	formaldehyde oxidation	100	3 of 3
66794	coenzyme A metabolism	100	4 of 4
66794	adipate degradation	100	2 of 2
66794	kanosamine biosynthesis II	100	2 of 2
66794	1,4-dihydroxy-6-naphthoate biosynthesis	100	6 of 6
66794	threonine metabolism	100	10 of 10
66794	acetate fermentation	100	4 of 4
66794	3-chlorocatechol degradation	100	5 of 5
66794	palmitate biosynthesis	100	22 of 22
66794	ppGpp biosynthesis	100	4 of 4
66794	cardiolipin biosynthesis	100	7 of 7
66794	methylglyoxal degradation	100	5 of 5
66794	butanoate fermentation	100	4 of 4
66794	valine metabolism	100	9 of 9
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	myo-inositol biosynthesis	100	10 of 10
66794	gallate degradation	100	5 of 5
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	isoleucine metabolism	100	8 of 8
66794	folate polyglutamylation	100	1 of 1
66794	taurine degradation	100	1 of 1
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	suberin monomers biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	aerobactin biosynthesis	100	1 of 1
66794	cellulose degradation	100	5 of 5
66794	lactate fermentation	100	4 of 4
66794	phenylalanine metabolism	92.31	12 of 13
66794	urea cycle	92.31	12 of 13
66794	proline metabolism	90.91	10 of 11
66794	pentose phosphate pathway	90.91	10 of 11
66794	serine metabolism	88.89	8 of 9
66794	CO2 fixation in Crenarchaeota	88.89	8 of 9
66794	d-mannose degradation	88.89	8 of 9
66794	chorismate metabolism	88.89	8 of 9
66794	NAD metabolism	88.89	16 of 18
66794	vitamin B12 metabolism	88.24	30 of 34
66794	glycolysis	88.24	15 of 17
66794	dTDPLrhamnose biosynthesis	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	flavin biosynthesis	86.67	13 of 15
66794	photosynthesis	85.71	12 of 14
66794	tetrahydrofolate metabolism	85.71	12 of 14
66794	heme metabolism	85.71	12 of 14
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	leucine metabolism	84.62	11 of 13
66794	alanine metabolism	82.76	24 of 29
66794	Entner Doudoroff pathway	80	8 of 10
66794	degradation of sugar acids	80	20 of 25
66794	ethylmalonyl-CoA pathway	80	4 of 5
66794	4-hydroxyphenylacetate degradation	80	8 of 10
66794	propionate fermentation	80	8 of 10
66794	glycine betaine biosynthesis	80	4 of 5
66794	factor 420 biosynthesis	80	4 of 5
66794	metabolism of amino sugars and derivatives	80	4 of 5
66794	glycogen metabolism	80	4 of 5
66794	peptidoglycan biosynthesis	80	12 of 15
66794	purine metabolism	79.79	75 of 94
66794	arginine metabolism	79.17	19 of 24
66794	glutathione metabolism	78.57	11 of 14
66794	citric acid cycle	78.57	11 of 14
66794	glutamate and glutamine metabolism	78.57	22 of 28
66794	allantoin degradation	77.78	7 of 9
66794	degradation of hexoses	77.78	14 of 18
66794	4-hydroxymandelate degradation	77.78	7 of 9
66794	methionine metabolism	76.92	20 of 26
66794	vitamin B1 metabolism	76.92	10 of 13
66794	non-pathway related	76.32	29 of 38
66794	tryptophan metabolism	76.32	29 of 38
66794	cyclohexanol degradation	75	3 of 4
66794	sulfopterin metabolism	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	phenol degradation	75	15 of 20
66794	glycogen biosynthesis	75	3 of 4
66794	pyrimidine metabolism	73.33	33 of 45
66794	cholesterol biosynthesis	72.73	8 of 11
66794	oxidative phosphorylation	72.53	66 of 91
66794	histidine metabolism	72.41	21 of 29
66794	cysteine metabolism	72.22	13 of 18
66794	degradation of pentoses	71.43	20 of 28
66794	lipid metabolism	70.97	22 of 31
66794	isoprenoid biosynthesis	69.23	18 of 26
66794	acetyl CoA biosynthesis	66.67	2 of 3
66794	cyanate degradation	66.67	2 of 3
66794	selenocysteine biosynthesis	66.67	4 of 6
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	acetoin degradation	66.67	2 of 3
66794	lysine metabolism	66.67	28 of 42
66794	IAA biosynthesis	66.67	2 of 3
66794	enterobactin biosynthesis	66.67	2 of 3
66794	tyrosine metabolism	64.29	9 of 14
66794	metabolism of disaccharids	63.64	7 of 11
66794	d-xylose degradation	63.64	7 of 11
66794	degradation of sugar alcohols	62.5	10 of 16
66794	ketogluconate metabolism	62.5	5 of 8
66794	sulfate reduction	61.54	8 of 13
66794	lipoate biosynthesis	60	3 of 5
66794	arachidonate biosynthesis	60	3 of 5
66794	bacilysin biosynthesis	60	3 of 5
66794	vitamin K metabolism	60	3 of 5
66794	bile acid biosynthesis, neutral pathway	58.82	10 of 17
66794	degradation of aromatic, nitrogen containing compounds	58.33	7 of 12
66794	aclacinomycin biosynthesis	57.14	4 of 7
66794	androgen and estrogen metabolism	56.25	9 of 16
66794	nitrate assimilation	55.56	5 of 9
66794	3-phenylpropionate degradation	53.33	8 of 15
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	toluene degradation	50	2 of 4
66794	sphingosine metabolism	50	3 of 6
66794	ribulose monophosphate pathway	50	1 of 2
66794	coenzyme M biosynthesis	50	5 of 10
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	ethanol fermentation	50	1 of 2
66794	vitamin E metabolism	50	2 of 4
66794	phenylmercury acetate degradation	50	1 of 2
66794	resorcinol degradation	50	1 of 2
66794	phenylpropanoid biosynthesis	46.15	6 of 13
66794	vitamin B6 metabolism	45.45	5 of 11
66794	carotenoid biosynthesis	45.45	10 of 22
66794	ascorbate metabolism	45.45	10 of 22
66794	lipid A biosynthesis	44.44	4 of 9
66794	benzoyl-CoA degradation	42.86	3 of 7
66794	glycine metabolism	40	4 of 10
66794	polyamine pathway	39.13	9 of 23
66794	arachidonic acid metabolism	38.89	7 of 18
66794	carnitine metabolism	37.5	3 of 8
66794	sulfoquinovose degradation	33.33	1 of 3
66794	(5R)-carbapenem carboxylate biosynthesis	33.33	1 of 3
66794	chlorophyll metabolism	33.33	6 of 18
66794	phosphatidylethanolamine bioynthesis	30.77	4 of 13
66794	dolichyl-diphosphooligosaccharide biosynthesis	27.27	3 of 11
66794	alginate biosynthesis	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12
66794	CMP-KDO biosynthesis	25	1 of 4
66794	daunorubicin biosynthesis	22.22	2 of 9

API zym

API 50CHac

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence AJ865857 (>99% sequence identity) for Catenulispora from Microbeatlas

Aquatic Samples	870
Soil Samples	16042
Animal Samples	1233
Plant Samples	2953
Total Samples	21098

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM2402v1 assembly for Catenulispora acidiphila DSM 44928	complete	GCA_000024025	479433.5	644736339	479433	98.88

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
12201	Catenulispora acidiphila partial 16S rRNA gene, type strain ID139908T	AJ865857	1441		479433

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Degradation of lignocellulose by different bacterial and fungal co-cultures.	Detain J, Besaury L.	Curr Res Microb Sci	10.1016/j.crmicr.2024.100271	2024
	Diterpene Biosynthesis in Catenulispora acidiphila: On the Mechanism of Catenul-14-en-6-ol Synthase.	Li G, Guo YW, Dickschat JS.	Angew Chem Int Ed Engl	10.1002/anie.202014180	2021
	Genome Mining and Gene Expression Reveal Maytansine Biosynthetic Genes from Endophytic Communities Living inside Gymnosporia heterophylla (Eckl. and Zeyh.) Loes. and the Relationship with the Plant Biosynthetic Gene, Friedelin Synthase.	Pitakbut T, Spiteller M, Kayser O.	Plants (Basel)	10.3390/plants11030321	2022
Genetics	A panoramic view of the genomic landscape of the genus Streptomyces.	Nikolaidis M, Hesketh A, Frangou N, Mossialos D, Van de Peer Y, Oliver SG, Amoutzias GD.	Microb Genom	10.1099/mgen.0.001028	2023
Enzymology	Structural characterization of a hypothetical protein: a potential agent involved in trimethylamine metabolism in Catenulispora acidiphila.	Filippova EV, Luan CH, Dunne SF, Kiryukhina O, Minasov G, Shuvalova L, Anderson WF.	J Struct Funct Genomics	10.1007/s10969-014-9176-z	2014
Genetics	Correlational networking guides the discovery of unclustered lanthipeptide protease-encoding genes.	Xue D, Older EA, Zhong Z, Shang Z, Chen N, Dittenhauser N, Hou L, Cai P, Walla MD, Dong SH, Tang X, Tang X, Chen H, Nagarkatti P, Nagarkatti M, Li YX, Li J.	Nat Commun	10.1038/s41467-022-29325-1	2022
Metabolism	Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.	Vuksanovic N, Zhu X, Serrano DA, Siitonen V, Metsa-Ketela M, Melancon CE, Silvaggi NR.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x20009814	2020
Metabolism	Characterization of LnmO as a pathway-specific Crp/Fnr-type positive regulator for leinamycin biosynthesis in Streptomyces atroolivaceus and its application for titer improvement.	Huang Y, Yang D, Pan G, Tang GL, Shen B.	Appl Microbiol Biotechnol	10.1007/s00253-016-7864-2	2016
Metabolism	Discovery of Lysine Hydroxylases in the Clavaminic Acid Synthase-Like Superfamily for Efficient Hydroxylysine Bioproduction.	Hara R, Yamagata K, Miyake R, Kawabata H, Uehara H, Kino K.	Appl Environ Microbiol	10.1128/aem.00693-17	2017
Metabolism	Genes associated with 2-methylisoborneol biosynthesis in cyanobacteria: isolation, characterization, and expression in response to light.	Wang Z, Xu Y, Shao J, Wang J, Li R.	PLoS One	10.1371/journal.pone.0018665	2011
Transcriptome	Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space.	Helbert W, Poulet L, Drouillard S, Mathieu S, Loiodice M, Couturier M, Lombard V, Terrapon N, Turchetto J, Vincentelli R, Henrissat B.	Proc Natl Acad Sci U S A	10.1073/pnas.1815791116	2019
	Genomic Insights into the Distribution and Phylogeny of Glycopeptide Resistance Determinants within the Actinobacteria Phylum.	Andreo-Vidal A, Binda E, Fedorenko V, Marinelli F, Yushchuk O.	Antibiotics (Basel)	10.3390/antibiotics10121533	2021
Metabolism	Identification of Critical Amino Acids Conferring Lethality in VopK, a Type III Effector Protein of Vibrio cholerae: Lessons from Yeast Model System.	Bankapalli LK, Mishra RC, Singh B, Raychaudhuri S.	PLoS One	10.1371/journal.pone.0141038	2015
Genetics	Comparative Genomics Analysis of Streptomyces Species Reveals Their Adaptation to the Marine Environment and Their Diversity at the Genomic Level.	Tian X, Zhang Z, Yang T, Chen M, Li J, Chen F, Yang J, Li W, Zhang B, Zhang Z, Wu J, Zhang C, Long L, Xiao J.	Front Microbiol	10.3389/fmicb.2016.00998	2016
Genetics	Actinomycetes as Producers of Biologically Active Terpenoids: Current Trends and Patents.	Tarasova EV, Luchnikova NA, Grishko VV, Ivshina IB.	Pharmaceuticals (Basel)	10.3390/ph16060872	2023
	Analysis of EAWAG-BBD pathway prediction system for the identification of malathion degrading microbes.	Sivakumar S, Anitha P, Ramesh B, Suresh G.	Bioinformation	10.6026/97320630013073	2017
Metabolism	Functional Analysis of a Novel beta-(1,3)-Glucanase from Corallococcus sp. Strain EGB Containing a Fascin-Like Module.	Zhou J, Li Z, Wu J, Li L, Li D, Ye X, Luo X, Huang Y, Cui Z, Cao H.	Appl Environ Microbiol	10.1128/aem.01016-17	2017
Metabolism	Defining sequence space and reaction products within the cyanuric acid hydrolase (AtzD)/barbiturase protein family.	Seffernick JL, Erickson JS, Cameron SM, Cho S, Dodge AG, Richman JE, Sadowsky MJ, Wackett LP.	J Bacteriol	10.1128/jb.00791-12	2012
Metabolism	Flavin-dependent N-hydroxylating enzymes: distribution and application.	Mugge C, Heine T, Baraibar AG, van Berkel WJH, Paul CE, Tischler D.	Appl Microbiol Biotechnol	10.1007/s00253-020-10705-w	2020
Enzymology	The crystal structure of the core domain of a cellulose induced protein (Cip1) from Hypocrea jecorina, at 1.5 Å resolution.	Jacobson F, Karkehabadi S, Hansson H, Goedegebuur F, Wallace L, Mitchinson C, Piens K, Stals I, Sandgren M.	PLoS One	10.1371/journal.pone.0070562	2013
Metabolism	Polysaccharide Degradation Capability of Actinomycetales Soil Isolates from a Semiarid Grassland of the Colorado Plateau.	Yeager CM, Gallegos-Graves V, Dunbar J, Hesse CN, Daligault H, Kuske CR.	Appl Environ Microbiol	10.1128/aem.03020-16	2017
Genetics	Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.	Rudolf JD, Yan X, Shen B.	J Ind Microbiol Biotechnol	10.1007/s10295-015-1671-0	2016
Metabolism	Biosynthesis of 2'-Chloropentostatin and 2'-Amino-2'-Deoxyadenosine Highlights a Single Gene Cluster Responsible for Two Independent Pathways in Actinomadura sp. Strain ATCC 39365.	Gao Y, Xu G, Wu P, Liu J, Cai YS, Deng Z, Chen W.	Appl Environ Microbiol	10.1128/aem.00078-17	2017
Phylogeny	Genome sequence of Kitasatospora setae NBRC 14216T: an evolutionary snapshot of the family Streptomycetaceae.	Ichikawa N, Oguchi A, Ikeda H, Ishikawa J, Kitani S, Watanabe Y, Nakamura S, Katano Y, Kishi E, Sasagawa M, Ankai A, Fukui S, Hashimoto Y, Kamata S, Otoguro M, Tanikawa S, Nihira T, Horinouchi S, Ohnishi Y, Hayakawa M, Kuzuyama T, Arisawa A, Nomoto F, Miura H, Takahashi Y, Fujita N.	DNA Res	10.1093/dnares/dsq026	2010
Metabolism	Cloning, Expression and Characterization of a Thermostable Esterase HydS14 from Actinomadura sp. Strain S14 in Pichia pastoris.	Sriyapai P, Kawai F, Siripoke S, Chansiri K, Sriyapai T.	Int J Mol Sci	10.3390/ijms160613579	2015
	Identification of the biosynthetic gene cluster for the pacidamycin group of peptidyl nucleoside antibiotics.	Zhang W, Ostash B, Walsh CT.	Proc Natl Acad Sci U S A	10.1073/pnas.1011557107	2010
	Cyanuric acid hydrolase: evolutionary innovation by structural concatenation.	Peat TS, Balotra S, Wilding M, French NG, Briggs LJ, Panjikar S, Cowieson N, Newman J, Scott C.	Mol Microbiol	10.1111/mmi.12249	2013
	Evolution of endonuclease IV protein family: an in silico analysis.	Kanchan S, Sharma P, Chowdhury S.	3 Biotech	10.1007/s13205-019-1696-6	2019
Enzymology	Rhodococcus sp. strain CR-53 LipR, the first member of a new bacterial lipase family (family X) displaying an unusual Y-type oxyanion hole, similar to the Candida antarctica lipase clan.	Bassegoda A, Pastor FI, Diaz P.	Appl Environ Microbiol	10.1128/aem.06332-11	2012
Transcriptome	In silico analysis highlights the frequency and diversity of type 1 lantibiotic gene clusters in genome sequenced bacteria.	Marsh AJ, O'Sullivan O, Ross RP, Cotter PD, Hill C.	BMC Genomics	10.1186/1471-2164-11-679	2010
Metabolism	Identification and characterization of the biosynthetic gene cluster of polyoxypeptin A, a potent apoptosis inducer.	Du Y, Wang Y, Huang T, Tao M, Deng Z, Lin S.	BMC Microbiol	10.1186/1471-2180-14-30	2014
	An Integrative Bioinformatic Analysis for Keratinase Detection in Marine-Derived Streptomyces.	Valencia R, Gonzalez V, Undabarrena A, Zamora-Leiva L, Ugalde JA, Camara B.	Mar Drugs	10.3390/md19060286	2021
	The secondary metabolites of rare actinomycetes: chemistry and bioactivity.	Ding T, Yang LJ, Zhang WD, Shen YH.	RSC Adv	10.1039/c9ra03579f	2019
	Heterologous expression of the thiopeptide antibiotic GE2270 from Planobispora rosea ATCC 53733 in Streptomyces coelicolor requires deletion of ribosomal genes from the expression construct.	Flinspach K, Kapitzke C, Tocchetti A, Sosio M, Apel AK.	PLoS One	10.1371/journal.pone.0090499	2014
Genetics	Comparative genomic analysis of Brevibacterium strains: insights into key genetic determinants involved in adaptation to the cheese habitat.	Pham NP, Layec S, Dugat-Bony E, Vidal M, Irlinger F, Monnet C.	BMC Genomics	10.1186/s12864-017-4322-1	2017
Metabolism	C-S bond cleavage by a polyketide synthase domain.	Ma M, Lohman JR, Liu T, Shen B.	Proc Natl Acad Sci U S A	10.1073/pnas.1508437112	2015
	Veillonella, Firmicutes: Microbes disguised as Gram negatives.	Vesth T, Ozen A, Andersen SC, Kaas RS, Lukjancenko O, Bohlin J, Nookaew I, Wassenaar TM, Ussery DW.	Stand Genomic Sci	10.4056/sigs.2981345	2013
Metabolism	Expansion of the aminoglycoside-resistance 16S rRNA (m(1)A1408) methyltransferase family: expression and functional characterization of four hypothetical enzymes of diverse bacterial origin.	Witek MA, Conn GL.	Biochim Biophys Acta	10.1016/j.bbapap.2014.06.012	2014
	Natural-Product-Based Solutions for Tropical Infectious Diseases.	Adegboye O, Field MA, Kupz A, Pai S, Sharma D, Smout MJ, Wangchuk P, Wong Y, Loiseau C.	Clin Microbiol Rev	10.1128/cmr.00348-20	2021
Enzymology	Expression of an extremely acidic beta-1,4-glucanase from thermoacidophilic Alicyclobacillus sp. A4 in Pichia pastoris is improved by truncating the gene sequence.	Bai Y, Wang J, Zhang Z, Shi P, Luo H, Huang H, Luo C, Yao B.	Microb Cell Fact	10.1186/1475-2859-9-33	2010
Metabolism	The actinomycin biosynthetic gene cluster of Streptomyces chrysomallus: a genetic hall of mirrors for synthesis of a molecule with mirror symmetry.	Keller U, Lang M, Crnovcic I, Pfennig F, Schauwecker F.	J Bacteriol	10.1128/jb.01526-09	2010
Metabolism	Genomics of aerobic cellulose utilization systems in actinobacteria.	Anderson I, Abt B, Lykidis A, Klenk HP, Kyrpides N, Ivanova N.	PLoS One	10.1371/journal.pone.0039331	2012
Metabolism	CRISPR immunity relies on the consecutive binding and degradation of negatively supercoiled invader DNA by Cascade and Cas3.	Westra ER, van Erp PB, Kunne T, Wong SP, Staals RH, Seegers CL, Bollen S, Jore MM, Semenova E, Severinov K, de Vos WM, Dame RT, de Vries R, Brouns SJ, van der Oost J.	Mol Cell	10.1016/j.molcel.2012.03.018	2012
Enzymology	Cyanohydrin phosphonate natural product from Streptomyces regensis.	Cioni JP, Doroghazi JR, Ju KS, Yu X, Evans BS, Lee J, Metcalf WW.	J Nat Prod	10.1021/np400722m	2014
Metabolism	Boronated tartrolon antibiotic produced by symbiotic cellulose-degrading bacteria in shipworm gills.	Elshahawi SI, Trindade-Silva AE, Hanora A, Han AW, Flores MS, Vizzoni V, Schrago CG, Soares CA, Concepcion GP, Distel DL, Schmidt EW, Haygood MG.	Proc Natl Acad Sci U S A	10.1073/pnas.1213892110	2013
	metaBEETL: high-throughput analysis of heterogeneous microbial populations from shotgun DNA sequences.	Ander C, Schulz-Trieglaff OB, Stoye J, Cox AJ.	BMC Bioinformatics	10.1186/1471-2105-14-s5-s2	2013
	Structure Characteristics, Biochemical Properties, and Pharmaceutical Applications of Alginate Lyases.	Gao SK, Yin R, Wang XC, Jiang HN, Liu XX, Lv W, Ma Y, Zhou YX.	Mar Drugs	10.3390/md19110628	2021
Metabolism	Biosynthesis of the allylmalonyl-CoA extender unit for the FK506 polyketide synthase proceeds through a dedicated polyketide synthase and facilitates the mutasynthesis of analogues.	Mo S, Kim DH, Lee JH, Park JW, Basnet DB, Ban YH, Yoo YJ, Chen SW, Park SR, Choi EA, Kim E, Jin YY, Lee SK, Park JY, Liu Y, Lee MO, Lee KS, Kim SJ, Kim D, Park BC, Lee SG, Kwon HJ, Suh JW, Moore BS, Lim SK, Yoon YJ.	J Am Chem Soc	10.1021/ja108399b	2011
Metabolism	Streptomycetes: Surrogate hosts for the genetic manipulation of biosynthetic gene clusters and production of natural products.	Nepal KK, Wang G.	Biotechnol Adv	10.1016/j.biotechadv.2018.10.003	2019
Metabolism	In vitro reconstitution of an Escherichia coli RNA-guided immune system reveals unidirectional, ATP-dependent degradation of DNA target.	Mulepati S, Bailey S.	J Biol Chem	10.1074/jbc.m113.472233	2013
	Prokaryotic caspase homologs: phylogenetic patterns and functional characteristics reveal considerable diversity.	Asplund-Samuelsson J, Bergman B, Larsson J.	PLoS One	10.1371/journal.pone.0049888	2012
Metabolism	Pleiotropic control of secondary metabolism and morphological development by KsbC, a butyrolactone autoregulator receptor homologue in Kitasatospora setae.	Aroonsri A, Kitani S, Hashimoto J, Kosone I, Izumikawa M, Komatsu M, Fujita N, Takahashi Y, Shin-ya K, Ikeda H, Nihira T.	Appl Environ Microbiol	10.1128/aem.02355-12	2012
Metabolism	Structure of an MmyB-like regulator from C. aurantiacus, member of a new transcription factor family linked to antibiotic metabolism in actinomycetes.	Xu Q, van Wezel GP, Chiu HJ, Jaroszewski L, Klock HE, Knuth MW, Miller MD, Lesley SA, Godzik A, Elsliger MA, Deacon AM, Wilson IA.	PLoS One	10.1371/journal.pone.0041359	2012
Metabolism	Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica.	Kersten RD, Lane AL, Nett M, Richter TK, Duggan BM, Dorrestein PC, Moore BS.	Chembiochem	10.1002/cbic.201300147	2013
Genetics	Active site and laminarin binding in glycoside hydrolase family 55.	Bianchetti CM, Takasuka TE, Deutsch S, Udell HS, Yik EJ, Bergeman LF, Fox BG.	J Biol Chem	10.1074/jbc.m114.623579	2015
Genetics	Developmental biology of Streptomyces from the perspective of 100 actinobacterial genome sequences.	Chandra G, Chater KF.	FEMS Microbiol Rev	10.1111/1574-6976.12047	2014
Enzymology	PKMiner: a database for exploring type II polyketide synthases.	Kim J, Yi GS.	BMC Microbiol	10.1186/1471-2180-12-169	2012
Metabolism	Lessons learned from the transformation of natural product discovery to a genome-driven endeavor.	Deane CD, Mitchell DA.	J Ind Microbiol Biotechnol	10.1007/s10295-013-1361-8	2014
Enzymology	Genome-based analysis of non-ribosomal peptide synthetase and type-I polyketide synthase gene clusters in all type strains of the genus Herbidospora.	Komaki H, Ichikawa N, Oguchi A, Hamada M, Tamura T, Fujita N.	BMC Res Notes	10.1186/s13104-015-1526-9	2015
Phylogeny	Phylogenetic framework and molecular signatures for the main clades of the phylum Actinobacteria.	Gao B, Gupta RS.	Microbiol Mol Biol Rev	10.1128/mmbr.05011-11	2012
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
Metabolism	New aminocoumarins from the rare actinomycete Catenulispora acidiphila DSM 44928: identification, structure elucidation, and heterologous production.	Zettler J, Xia H, Burkard N, Kulik A, Grond S, Heide L, Apel AK	Chembiochem	10.1002/cbic.201300712	2014
Metabolism	Identification and characterization of 2-oxoglutarate-dependent dioxygenases catalyzing selective cis-hydroxylation of proline and pipecolinic acid from actinomycetes.	Hara R, Uchiumi N, Kino K	J Biotechnol	10.1016/j.jbiotec.2013.12.003	2013
Metabolism	Biosynthesis of the class III lantipeptide catenulipeptin.	Wang H, van der Donk WA	ACS Chem Biol	10.1021/cb3002446	2012
Genetics	Complete genome sequence of Catenulispora acidiphila type strain (ID 139908).	Copeland A, Lapidus A, Glavina Del Rio T, Nolan M, Lucas S, Chen F, Tice H, Cheng JF, Bruce D, Goodwin L, Pitluck S, Mikhailova N, Pati A, Ivanova N, Mavromatis K, Chen A, Palaniappan K, Chain P, Land M, Hauser L, Chang YJ, Jeffries CD, Chertkov O, Brettin T, Detter JC, Han C, Ali Z, Tindall BJ, Goker M, Bristow J, Eisen JA, Markowitz V, Hugenholtz P, Kyrpides NC, Klenk HP	Stand Genomic Sci	10.4056/sigs.17259	2009
Phylogeny	Catenulispora acidiphila gen. nov., sp. nov., a novel, mycelium-forming actinomycete, and proposal of Catenulisporaceae fam. nov.	Busti E, Cavaletti L, Monciardini P, Schumann P, Rohde M, Sosio M, Donadio S	Int J Syst Evol Microbiol	10.1099/ijs.0.63858-0	2006
Phylogeny	Genomic-based classification of Catenulispora pinisilvae sp. nov., novel actinobacteria isolated from a pine forest soil in Poland and emended description of Catenulispora rubra.	Swiecimska M, Golinska P, Wypij M, Goodfellow M	Syst Appl Microbiol	10.1016/j.syapm.2020.126164	2020