Selenomonas sputigena (DSM 20758, ATCC 35185, CCUG 44933)

Cell morphology

Colony morphology

Multimedia

• @ref:	66793
  multimedia content:	EM_DSM_20758_1.jpg
  multimedia.multimedia content:	EM_DSM_20758_1.jpg
  caption:	electron microscopic image
  intellectual property rights:	© HZI/Manfred Rohde
  manual_annotation:	1

Culture medium

@ref	Name	Growth	Medium link	Composition
9065	CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110)		Medium recipe at MediaDive	Name: CHOPPED MEAT MEDIUM WITH CARBOHYDRATES (DSMZ Medium 110) Composition: Ground beef 500.0 g/l Casitone 30.0 g/l Agar 15.0 g/l K2HPO4 5.0 g/l Yeast extract 5.0 g/l D-Glucose 4.0 g/l Starch 1.0 g/l Maltose 1.0 g/l Cellobiose 1.0 g/l L-Cysteine HCl 0.5 g/l Ethanol 0.19 g/l Vitamin K3 0.05 g/l Hemin 0.005 g/l Sodium resazurin 0.0005 g/l Vitamin K1 NaOH Distilled water
9065	PYG MEDIUM (MODIFIED) (DSMZ Medium 104)		Medium recipe at MediaDive	Name: PYG MEDIUM (modified) (DSMZ Medium 104) Composition: Yeast extract 10.0 g/l Peptone 5.0 g/l Trypticase peptone 5.0 g/l Beef extract 5.0 g/l Glucose 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l K2HPO4 0.04 g/l KH2PO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Hemin 0.005 g/l Ethanol 0.0038 g/l Resazurin 0.001 g/l Tween 80 Vitamin K1 NaOH Distilled water

Culture temp

Oxygen tolerance

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68380	29016 ChEBI	arginine	-	hydrolysis	from API rID32A
68380	16024 ChEBI	D-mannose	-	fermentation	from API rID32A
68380	29985 ChEBI	L-glutamate	-	degradation	from API rID32A
68380	17632 ChEBI	nitrate	-	reduction	from API rID32A
68380	16634 ChEBI	raffinose	-	fermentation	from API rID32A
68380	27897 ChEBI	tryptophan	-	energy source	from API rID32A
68380	16199 ChEBI	urea	-	hydrolysis	from API rID32A

Metabolite production

@ref	Chebi-ID	Metabolite	Production
68380	35581 ChEBI	indole		from API rID32A

Metabolite tests

@ref	Chebi-ID	Metabolite	Indole test
68380	35581 ChEBI	indole	-	from API rID32A

Enzymes

@ref	Value	Activity	Ec
68380	alanine arylamidase	-	3.4.11.2	from API rID32A
68380	alpha-arabinosidase	-	3.2.1.55	from API rID32A
68380	alpha-fucosidase	-	3.2.1.51	from API rID32A
68380	alpha-galactosidase	+	3.2.1.22	from API rID32A
68380	arginine dihydrolase	-	3.5.3.6	from API rID32A
68380	beta-galactosidase	+	3.2.1.23	from API rID32A
68380	beta-Galactosidase 6-phosphate	-		from API rID32A
68380	beta-glucosidase	-	3.2.1.21	from API rID32A
68380	beta-glucuronidase	-	3.2.1.31	from API rID32A
68380	glutamate decarboxylase	-	4.1.1.15	from API rID32A
68380	glutamyl-glutamate arylamidase	-		from API rID32A
68380	glycin arylamidase	-		from API rID32A
68380	histidine arylamidase	-		from API rID32A
68380	L-arginine arylamidase	-		from API rID32A
68380	leucine arylamidase	-	3.4.11.1	from API rID32A
68380	leucyl glycin arylamidase	-	3.4.11.1	from API rID32A
68380	N-acetyl-beta-glucosaminidase	-	3.2.1.52	from API rID32A
68380	phenylalanine arylamidase	-		from API rID32A
68380	proline-arylamidase	-	3.4.11.5	from API rID32A
68380	pyrrolidonyl arylamidase	-	3.4.19.3	from API rID32A
68380	serine arylamidase	-		from API rID32A
68380	tryptophan deaminase	-	4.1.99.1	from API rID32A
68380	tyrosine arylamidase	-		from API rID32A
68380	urease	-	3.5.1.5	from API rID32A

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions	external links
66794	reductive acetyl coenzyme A pathway	100	7 of 7
66794	coenzyme A metabolism	100	4 of 4
66794	cis-vaccenate biosynthesis	100	2 of 2
66794	sulfopterin metabolism	100	4 of 4
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	palmitate biosynthesis	100	22 of 22
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	ppGpp biosynthesis	100	4 of 4
66794	ethanol fermentation	100	2 of 2
66794	folate polyglutamylation	100	1 of 1
66794	biotin biosynthesis	100	4 of 4
66794	suberin monomers biosynthesis	100	2 of 2
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	starch degradation	90	9 of 10
66794	propionate fermentation	90	9 of 10
66794	chorismate metabolism	88.89	8 of 9
66794	lipid A biosynthesis	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	vitamin B12 metabolism	88.24	30 of 34
66794	C4 and CAM-carbon fixation	87.5	7 of 8
66794	gluconeogenesis	87.5	7 of 8
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	ubiquinone biosynthesis	85.71	6 of 7
66794	hydrogen production	80	4 of 5
66794	threonine metabolism	80	8 of 10
66794	glycogen metabolism	80	4 of 5
66794	pyrimidine metabolism	80	36 of 45
66794	cellulose degradation	80	4 of 5
66794	methylglyoxal degradation	80	4 of 5
66794	tetrahydrofolate metabolism	78.57	11 of 14
66794	photosynthesis	78.57	11 of 14
66794	serine metabolism	77.78	7 of 9
66794	d-mannose degradation	77.78	7 of 9
66794	vitamin B1 metabolism	76.92	10 of 13
66794	glycolysis	76.47	13 of 17
66794	CMP-KDO biosynthesis	75	3 of 4
66794	glycogen biosynthesis	75	3 of 4
66794	isoleucine metabolism	75	6 of 8
66794	acetate fermentation	75	3 of 4
66794	flavin biosynthesis	73.33	11 of 15
66794	methionine metabolism	73.08	19 of 26
66794	vitamin B6 metabolism	72.73	8 of 11
66794	heme metabolism	71.43	10 of 14
66794	citric acid cycle	71.43	10 of 14
66794	propanol degradation	71.43	5 of 7
66794	phenylalanine metabolism	69.23	9 of 13
66794	alanine metabolism	68.97	20 of 29
66794	molybdenum cofactor biosynthesis	66.67	6 of 9
66794	cyanate degradation	66.67	2 of 3
66794	L-lactaldehyde degradation	66.67	2 of 3
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	glycolate and glyoxylate degradation	66.67	4 of 6
66794	acetoin degradation	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	NAD metabolism	66.67	12 of 18
66794	purine metabolism	63.83	60 of 94
66794	degradation of sugar alcohols	62.5	10 of 16
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	isoprenoid biosynthesis	61.54	16 of 26
66794	oxidative phosphorylation	61.54	56 of 91
66794	glutamate and glutamine metabolism	60.71	17 of 28
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	glycine betaine biosynthesis	60	3 of 5
66794	4-hydroxyphenylacetate degradation	60	6 of 10
66794	CO2 fixation in Crenarchaeota	55.56	5 of 9
66794	pentose phosphate pathway	54.55	6 of 11
66794	leucine metabolism	53.85	7 of 13
66794	phosphatidylethanolamine bioynthesis	53.85	7 of 13
66794	non-pathway related	52.63	20 of 38
66794	lysine metabolism	52.38	22 of 42
66794	glycine metabolism	50	5 of 10
66794	coenzyme M biosynthesis	50	5 of 10
66794	arginine metabolism	50	12 of 24
66794	dTDPLrhamnose biosynthesis	50	4 of 8
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	phenylmercury acetate degradation	50	1 of 2
66794	1,4-dihydroxy-6-naphthoate biosynthesis	50	3 of 6
66794	tryptophan metabolism	50	19 of 38
66794	mannosylglycerate biosynthesis	50	1 of 2
66794	lactate fermentation	50	2 of 4
66794	adipate degradation	50	1 of 2
66794	cysteine metabolism	50	9 of 18
66794	histidine metabolism	48.28	14 of 29
66794	polyamine pathway	47.83	11 of 23
66794	lipid metabolism	45.16	14 of 31
66794	nitrate assimilation	44.44	4 of 9
66794	tyrosine metabolism	42.86	6 of 14
66794	cardiolipin biosynthesis	42.86	3 of 7
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	Entner Doudoroff pathway	40	4 of 10
66794	arachidonate biosynthesis	40	2 of 5
66794	elloramycin biosynthesis	40	2 of 5
66794	urea cycle	38.46	5 of 13
66794	ketogluconate metabolism	37.5	3 of 8
66794	metabolism of disaccharids	36.36	4 of 11
66794	proline metabolism	36.36	4 of 11
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	pantothenate biosynthesis	33.33	2 of 6
66794	degradation of hexoses	33.33	6 of 18
66794	octane oxidation	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	enterobactin biosynthesis	33.33	1 of 3
66794	myo-inositol biosynthesis	30	3 of 10
66794	glutathione metabolism	28.57	4 of 14
66794	d-xylose degradation	27.27	3 of 11
66794	ascorbate metabolism	27.27	6 of 22
66794	3-phenylpropionate degradation	26.67	4 of 15
66794	cyclohexanol degradation	25	1 of 4
66794	degradation of pentoses	25	7 of 28
66794	butanoate fermentation	25	1 of 4
66794	phenol degradation	25	5 of 20
66794	toluene degradation	25	1 of 4
66794	degradation of sugar acids	24	6 of 25
66794	sulfate reduction	23.08	3 of 13
66794	phenylpropanoid biosynthesis	23.08	3 of 13

API rID32A

Isolation source categories

Isolation

Taxonmaps

69479

Global distribution of 16S sequence CP002637 (>99% sequence identity) for Selenomonas sputigena subclade from Microbeatlas

Aquatic Samples	28
Soil Samples	21
Animal Samples	923
Plant Samples	15
Total Samples	987

Risk assessment

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM20840v1 assembly for Selenomonas sputigena ATCC 35185	complete	GCA_000208405	546271.5	2504557006	546271	99.03
66792	ASM16049v1 assembly for Selenomonas sputigena ATCC 35185	scaffold	GCA_000160495	546271.3	645951802	546271	66.99

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Selenomonas sputigena 16S ribosomal RNA gene, partial sequence	AF287793	1497		546271
20218	Selenomonas sputigena strain ATCC35185 16S ribosomal RNA gene, partial sequence	AF373023	1499		546271

GC content

Predictions

Literature

Topic	Title	Authors	Journal	DOI	Year
	Development of the First Shuttle Vector System and Optimization of Transformation in Selenomonas sputigena.	Nguyen TT, Kim YK, Ko D, Kim J, Yi H, Bang YJ.	J Microbiol Biotechnol	10.4014/jmb.2501.01011	2025
	Veillonella, Firmicutes: Microbes disguised as Gram negatives.	Vesth T, Ozen A, Andersen SC, Kaas RS, Lukjancenko O, Bohlin J, Nookaew I, Wassenaar TM, Ussery DW.	Stand Genomic Sci	10.4056/sigs.2981345	2013
	Filifactor alocis--involvement in periodontal biofilms.	Schlafer S, Riep B, Griffen AL, Petrich A, Hubner J, Berning M, Friedmann A, Gobel UB, Moter A.	BMC Microbiol	10.1186/1471-2180-10-66	2010
	Periodontal Health in Individuals Living with HIV: An Exploratory and Descriptive Molecular Approach of Microbial Interspecific and Intraspecific Diversity in Brazilian Patients.	Ponce PNO, Chaves LB, Perce-da-Silva DS, Carneiro-Alencar AL, Rodolphi CM, Soares IF, Rodrigues-da-Silva RN, Alves-da-Silva AC, Marques FV, Peres RV, Ferreira DC, de Souza RC, Goncalves C, Goncalves LS, Lima-Junior JDC.	Microorganisms	10.3390/microorganisms13040867	2025
Genetics	Deeply branching Bacillota species exhibit atypical Gram-negative staining.	Choi JK, Poudel S, Yee N, Goff JL.	Microbiol Spectr	10.1128/spectrum.00732-24	2024
	Selenomonas sputigena acts as a pathobiont mediating spatial structure and biofilm virulence in early childhood caries.	Cho H, Ren Z, Divaris K, Roach J, Lin BM, Liu C, Azcarate-Peril MA, Simancas-Pallares MA, Shrestha P, Orlenko A, Ginnis J, North KE, Zandona AGF, Ribeiro AA, Wu D, Koo H.	Nat Commun	10.1038/s41467-023-38346-3	2023
	Antibiofilm Activity of LL-37 Peptide and D-Amino Acids Associated with Antibiotics Used in Regenerative Endodontics on an Ex Vivo Multispecies Biofilm Model.	Pereira ACC, Aguiar APS, Araujo LMP, Dantas LO, Mayer MPA, Karygianni L, Thurnheer T, Pinheiro ET.	Life (Basel)	10.3390/life12111686	2022
	Microbiota and gastric cancer: from molecular mechanisms to therapeutic strategies.	Chen Z, Jin D, Hu J, Guan D, Bai Q, Gou Y.	Front Cell Infect Microbiol	10.3389/fcimb.2025.1563061	2025
Metabolism	Flagellin Glycoproteomics of the Periodontitis Associated Pathogen Selenomonas sputigena Reveals Previously Not Described O-glycans and Rhamnose Fragment Rearrangement Occurring on the Glycopeptides.	Rath CB, Schirmeister F, Figl R, Seeberger PH, Schaffer C, Kolarich D.	Mol Cell Proteomics	10.1074/mcp.ra117.000394	2018
	Palaeoproteomic investigation of an ancient human skeleton with abnormal deposition of dental calculus.	Uchida-Fukuhara Y, Shimamura S, Sawafuji R, Nishiuchi T, Yoneda M, Ishida H, Matsumura H, Tsutaya T.	Sci Rep	10.1038/s41598-024-55779-y	2024
	Endodontic-Like Oral Biofilms as Models for Multispecies Interactions in Endodontic Diseases.	Lukic D, Karygianni L, Flury M, Attin T, Thurnheer T.	Microorganisms	10.3390/microorganisms8050674	2020
	Role of the gut microbiome in three major psychiatric disorders.	Borkent J, Ioannou M, Laman JD, Haarman BCM, Sommer IEC, Sommer IEC.	Psychol Med	10.1017/s0033291722000897	2022
	Antibacterial Effect of Sodium Hypochlorite and EDTA in Combination with High-Purity Nisin on an Endodontic-like Biofilm Model.	Pinheiro ET, Karygianni L, Attin T, Thurnheer T.	Antibiotics (Basel)	10.3390/antibiotics10091141	2021
	Antibacterial Effect of High-Purity Nisin Alone and in Combination with D-Amino Acids or Chlorhexidine in an Endodontic-Like Biofilm Model.	Pinheiro ET, Karygianni L, Attin T, Thurnheer T.	Antibiotics (Basel)	10.3390/antibiotics10020149	2021
	Improved High-Throughput Sequencing of the Human Oral Microbiome: From Illumina to PacBio.	Zhang J, Su L, Wang Y, Deng S.	Can J Infect Dis Med Microbiol	10.1155/2020/6678872	2020
Genetics	A Comprehensive Evolutionary Scenario of Cell Division and Associated Processes in the Firmicutes.	Garcia PS, Duchemin W, Flandrois JP, Gribaldo S, Grangeasse C, Brochier-Armanet C.	Mol Biol Evol	10.1093/molbev/msab034	2021
Metabolism	Identification and characterization of three novel lipases belonging to families II and V from Anaerovibrio lipolyticus 5ST.	Prive F, Kaderbhai NN, Girdwood S, Worgan HJ, Pinloche E, Scollan ND, Huws SA, Newbold CJ.	PLoS One	10.1371/journal.pone.0069076	2013
	CMG-biotools, a free workbench for basic comparative microbial genomics.	Vesth T, Lagesen K, Acar O, Ussery D.	PLoS One	10.1371/journal.pone.0060120	2013
	Metagenomic Analysis Reveals A Possible Association Between Respiratory Infection and Periodontitis.	Liu Z, Zhang T, Wu K, Li Z, Chen X, Jiang S, Du L, Lu S, Lin C, Wu J, Wang X.	Genomics Proteomics Bioinformatics	10.1016/j.gpb.2021.07.001	2022
	Saliva microbiome, dietary, and genetic markers are associated with suicidal ideation in university students.	Ahrens AP, Sanchez-Padilla DE, Drew JC, Oli MW, Roesch LFW, Triplett EW.	Sci Rep	10.1038/s41598-022-18020-2	2022
	Immune status, and not HIV infection or exposure, drives the development of the oral microbiota.	Coker MO, Mongodin EF, El-Kamary SS, Akhigbe P, Obuekwe O, Omoigberale A, Langenberg P, Enwonwu C, Hittle L, Blattner WA, Charurat M.	Sci Rep	10.1038/s41598-020-67487-4	2020
	Multi-CAR: a tool of contig scaffolding using multiple references.	Chen KT, Chen CJ, Shen HT, Liu CL, Huang SH, Lu CL.	BMC Bioinformatics	10.1186/s12859-016-1328-7	2016
Transcriptome	Gene expression of bacterial collagenolytic proteases in root caries.	Dame-Teixeira N, Parolo CCF, Maltz M, Rup AG, Devine DA, Do T.	J Oral Microbiol	10.1080/20002297.2018.1424475	2018
Transcriptome	Investigating the Campylobacter jejuni Transcriptional Response to Host Intestinal Extracts Reveals the Involvement of a Widely Conserved Iron Uptake System.	Liu MM, Boinett CJ, Chan ACK, Parkhill J, Murphy MEP, Gaynor EC.	mBio	10.1128/mbio.01347-18	2018
Genetics	CAR: contig assembly of prokaryotic draft genomes using rearrangements.	Lu CL, Chen KT, Huang SY, Chiu HT.	BMC Bioinformatics	10.1186/s12859-014-0381-3	2014
Enzymology	Cultivation of a Synergistetes strain representing a previously uncultivated lineage.	Vartoukian SR, Palmer RM, Wade WG.	Environ Microbiol	10.1111/j.1462-2920.2009.02135.x	2010
Genetics	Genomic Analysis of the Human Gut Microbiome Suggests Novel Enzymes Involved in Quinone Biosynthesis.	Ravcheev DA, Thiele I.	Front Microbiol	10.3389/fmicb.2016.00128	2016
	SIS: a program to generate draft genome sequence scaffolds for prokaryotes.	Dias Z, Dias U, Setubal JC.	BMC Bioinformatics	10.1186/1471-2105-13-96	2012
	Systemic antibiotic therapy in periodontics.	Kapoor A, Malhotra R, Grover V, Grover D.	Dent Res J (Isfahan)	10.4103/1735-3327.104866	2012
	Characterization of Egg Yolk Antibodies for Detection and Quantification of Selenomonas ruminantium by Using an Enzyme-Linked Immunosorbent Assay.	Ricke SC, Schaefer DM.	Appl Environ Microbiol	10.1128/aem.56.9.2795-2800.1990	1990
Enzymology	A rapid method for extraction and purification of DNA from dental plaque.	Parrish KD, Greenberg EP.	Appl Environ Microbiol	10.1128/aem.61.11.4120-4123.1995	1995
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
Metabolism	Metabolic profiling and genetic tool development in the mucosal bacterium Selenomonas sputigena.	Nguyen TT, Kim YK, Nguyen TVT, Kwon J, Bang YJ.	Genes Genomics	10.1007/s13258-025-01668-1	2025
	Draft genome sequence of Selenomonas sputigena strain ATCC 33150 isolated from human mouth.	Wang T, Hawkes CG, Ridlon JM, Miller DP.	Microbiol Resour Announc	10.1128/mra.00827-25	2025
	Salivary Biomarker Panel That Identifies Periodontitis in Persons With Type 2 Diabetes: A Secondary Analysis of a Cross-Sectional Study.	Miller CS, Yan Q, Kirakodu SS, Ebersole JL, Zhang XD.	J Clin Periodontol	10.1111/jcpe.70049	2025
Phylogeny	The site-specific subgingival microbiome across periodontal conditions and its relationship with clinical parameters.	Chen K, Ren X, Du R, Lei L, Cheng R, Hu T.	Clin Oral Investig	10.1007/s00784-025-06625-6	2025
	Microbiological Investigation and Clinical Efficacy of Professional Topical Fluoride Application on Streptococcus mutans and Selemonas sputigena in Orthodontic Patients: A Randomized Controlled Clinical Trial.	Pardo A, Marcoccia S, Montagnini C, Signoriello A, Messina E, Gaibani P, Burlacchini G, Salgarelli C, Signoretto C, Zerman N.	Microorganisms	10.3390/microorganisms13112506	2025
	A study on the microbiome within oropharyngeal cancer tissues.	Sun R, Xing L, Wang W, Cui X, Guo Y, Gao F, Geng B, Cheng H, Liang H.	Discov Oncol	10.1007/s12672-025-02534-y	2025
Phylogeny	Associations of Salivary Microbiota with Diet Quality, Body Mass Index, and Oral Health Status in Turkish Adolescents.	Aslan Gonul B, Delikan E, Cicek B, Yilmaz Cankilic M.	Nutrients	10.3390/nu17213434	2025
Pathogenicity	Selenomonas sputigena Interactions with Gingival Epithelial Cells That Promote Inflammation.	Hawkes CG, Hinson AN, Vashishta A, Read CB, Carlyon JA, Lamont RJ, Uriarte SM, Miller DP.	Infect Immun	10.1128/iai.00319-22	2023
	New putative periodontopathogens and periodontal health-associated species: A systematic review and meta-analysis.	Antezack A, Etchecopar-Etchart D, La Scola B, Monnet-Corti V.	J Periodontal Res	10.1111/jre.13173	2023
	Oral care for intubated patients in the intensive care unit: examination of bacterial count and microbiota.	Kanamori D, Fujii T, Yoshida M, Ito R, Sakai A, Takahashi H, Kuramitsu K, Funasaka K, Ohno E, Hirooka Y, Tochio T.	Crit Care	10.1186/s13054-025-05576-4	2025
	Multiomics Analysis Reveals Significant Disparities in the Oral Microbiota and Metabolites Between Pregnant Women with and without Periodontitis.	Zhao M, Yang C, Zhu L, Guo X, Ma H, Luo Y, Wang Q, Chen J.	Infect Drug Resist	10.2147/idr.s475164	2024
	Profiles of oral microbiota and metabolites in periodontitis and benign prostatic hyperplasia patients: a pilot study.	Zhu C, Li L-Y, Li C, Wu L, Zhang Y-Y, Yao Y, Yang J, Wang S-Y, Xing L-M, Zeng X-T, Fang C.	Microbiol Spectr	10.1128/spectrum.03376-24	2025
	Oral Pathobionts Aggravate Myocardial Infarction Through Mobilization of B2 Cells.	Chen BY, Zhu H, Li YL, Zhang J, Xu S, Zhou LJ, Du LJ, Liu T, Sun XN, Tian GC, Li J, Meng XQ, Ye HL, Bai XB, Lin WZ, Li HX, Li JX, Sun JY, Liu Y, Zhang WC, Zhang L, Fang JY, Xu D, Yu M, Dai Y, Chen Q, Duan SZ.	Circulation	10.1161/circulationaha.125.074837	2025
	DMAHDM@MPC nanoparticles in orthodontic adhesive inhibit cariogenic bacteria and sugar metabolism to prevent enamel demineralization.	Su C, Zhu M, Guo Y, Sun J, Liu M, Ma Y, Xu Y, Bai Y, Che X, Zhang N.	Mater Today Bio	10.1016/j.mtbio.2025.101969	2025
	Influence of orthodontic appliances and nitrate on the oral microbiota.	Reichardt E, Eigenthaler M, Jost-Brinkmann PG, Stellzig-Eisenhauer A, Verna C, Plumeier I, Kahl S, Junca H, Vilchez-Vargas R, Pieper DH.	Appl Microbiol Biotechnol	10.1007/s00253-025-13496-0	2025
	Faeces from malnourished colorectal cancer patients accelerate cancer progression.	Chao X, Lei Z, Hongqin L, Ziwei W, Dechuan L, Weidong D, Lu X, Haitao C, Bo Z, Haixing J, Qinghua Y.	Clin Nutr	10.1016/j.clnu.2022.01.001	2022
	A deep learning feature importance test framework for integrating informative high-dimensional biomarkers to improve disease outcome prediction.	Zou B, Xenakis JG, Xiao M, Ribeiro A, Divaris K, Wu D, Zou F.	Brief Bioinform	10.1093/bib/bbae709	2024
	Association of supragingival plaque management with subgingival microbiota is moderated by adjunctive antibiotics in stage III-IV periodontitis patients during periodontal therapy.	Saberi Kakhki KCL, Harks I, Matern J, Prior K, Eickholz P, Lorenz K, Kim TS, Kocher T, Meyle J, Kaner D, Jockel-Schneider Y, Harmsen D, Ehmke B, Kleine Bardenhorst S, Hagenfeld D.	J Oral Microbiol	10.1080/20002297.2025.2517043	2025
Phylogeny	Comparative analysis of bacterial abundance and diversity in tumour tissue of oral squamous cell carcinoma and non-tumour tissue: insights from a systematic review of 16S ribosomal RNA sequencing.	Mohapatra S, Panda S, Mohanty N, Mishra BP.	BMC Oral Health	10.1186/s12903-025-05941-3	2025
	Longitudinal Microbiome Changes in Supragingival Biofilm Transcriptomes Induced by Orthodontics.	Babikow E, Ghaltakhchyan N, Livingston T, Qu Y, Liu C, Hoxie A, Sulkowski T, Bocklage C, Marsh A, Phillips ST, Mitchell KB, Ribeiro AA, Jackson TH, Roach J, Wu D, Divaris K, Jacox LA.	JDR Clin Trans Res	10.1177/23800844231199393	2024
	Supragingival microbiome variations and the influence of Candida albicans in adolescent orthodontic patients with gingivitis.	Yang H, Ma Y, Gao H, Xie X, Wang H, Li X, Bai Y.	J Oral Microbiol	10.1080/20002297.2024.2366056	2024
Genetics	Assessing peri-implant bacterial community structure: the effect of microbiome sample collection method.	Anitua E, Murias-Freijo A, Tierno R, Tejero R, Alkhraisat MH.	BMC Oral Health	10.1186/s12903-024-04675-y	2024
Phylogeny	Supragingival microbial profiles in caries-free and caries-active adolescents treated with fixed orthodontics.	Miao X, Cao H, Chen J, Gao Y, Li J, Zhang B, Nie M, Yu M.	Curr Res Microb Sci	10.1016/j.crmicr.2025.100455	2025
	Roles of intralesional bacteria in the initiation and progression of oral squamous cell carcinoma.	Luo Z, Lv S, Lou F, Yan L, Xu J, Kang N, Dong Y, Jin X.	Cancer Med	10.1002/cam4.70209	2024
Phylogeny	On the Oral Microbiome of Oral Potentially Malignant and Malignant Disorders: Dysbiosis, Loss of Diversity, and Pathogens Enrichment.	Herreros-Pomares A, Hervas D, Bagan-Debon L, Jantus-Lewintre E, Gimeno-Cardona C, Bagan J.	Int J Mol Sci	10.3390/ijms24043466	2023
	Exploring Epigenetic Mechanisms in Aggressive Periodontitis; Unraveling the Molecular Dynamics of Disease Progression: A Narrative Review.	Grevanny R, Suhartono AW, Amin AHR, Auerkari EI.	Iran J Med Sci	10.30476/ijms.2024.100801.3332	2024
	Pyrosequencing of the subgingival microbiome in peri-implantitis after non-surgical mechanical debridement therapy.	Nie J, Zhang Q, Zheng H, Xu LX, Wang XY, Chen F.	J Periodontal Res	10.1111/jre.12708	2020
	Microbiome variability and role of Candida albicans in site-specific dental plaques in orthodontic adolescent patients with white spot lesions.	Yang H, Gao H, Xie X, Wang H, Li X, Qiao Q, Ma Y, Bai Y.	J Oral Microbiol	10.1080/20002297.2025.2522421	2025
	Extraction Protocol for Parallel Analysis of Proteins and DNA from Ancient Teeth and Dental Calculus.	Chocholova E, Roudnicky P, Potesil D, Fialova D, Krystofova K, Drozdova E, Zdrahal Z.	J Proteome Res	10.1021/acs.jproteome.3c00370	2023
Phylogeny	Association of nine pathobionts with periodontitis in four South American and European countries.	Alvarez G, Arredondo A, Isabal S, Teughels W, Laleman I, Contreras MJ, Isbej L, Huapaya E, Mendoza G, Mor C, Nart J, Blanc V, Leon R.	J Oral Microbiol	10.1080/20002297.2023.2188630	2023
	Polymicrobial detection and salivary metabolomics of children with early childhood caries.	Pan T, Ren Y, Li J, Liao Y, Xing X.	PeerJ	10.7717/peerj.19399	2025
	Effects of removing in-feed antibiotics and zinc oxide on the taxonomy and functionality of the microbiota in post weaning pigs.	Ortiz Sanjuan JM, Arguello H, Cabrera-Rubio R, Crispie F, Cotter PD, Garrido JJ, Ekhlas D, Burgess CM, Manzanilla EG.	Anim Microbiome	10.1186/s42523-024-00306-7	2024
	Efficacy of Toothpaste Containing Polylysine and Funme Peptide on Oral Microbiome and Oral Health.	Liu X, Meng L, Song W, Zhi M, Wang P, Liu B, Du M, Feng Q.	Int Dent J	10.1016/j.identj.2024.11.017	2025
Phylogeny	Alterations in subgingival microbiome and advanced glycation end-products levels in periodontitis with and without type 1 diabetes mellitus: a cross-sectional study.	Chen J, Wang H, Bu S, Cheng X, Hu X, Shen M, Zhuang H.	BMC Oral Health	10.1186/s12903-024-05089-6	2024
	Activation of cellular responses by cyclic dinucleotides and porphyromonas gingivalis lipopolysaccharide: a proteomic study on gingival fibroblasts.	Elmanfi S, Onyedibe KI, Aryal UK, Kononen E, Sintim HO, Gursoy UK.	J Oral Microbiol	10.1080/20002297.2024.2431453	2025
	Toxic cultures: e-cigarettes and the oral microbial exposome.	Beverly ML, Chaudhary PP, Dabdoub SM, Kim S, Chatzakis E, Williamson K, Ganesan SM, Yadav M, Ratley G, D'Souza BN, Myles IA, Kumar PS.	NPJ Biofilms Microbiomes	10.1038/s41522-025-00709-7	2025
	Oral microbiome and ischemic stroke risk among elderly Chinese women.	Wang C, Yang Y, Cai Q, Gao Y, Cai H, Wu J, Zheng W, Long J, Shu XO.	J Oral Microbiol	10.1080/20002297.2023.2266655	2023
	A cross-cohort analysis of dental plaque microbiome in early childhood caries.	Khan MW, Fung DLX, Schroth RJ, Chelikani P, Hu P.	iScience	10.1016/j.isci.2024.110447	2024
Phylogeny	Identifying fecal microbiota signatures of colorectal cancer in a Vietnamese cohort.	Nhung PTT, Le HTT, Nguyen QH, Huyen DT, Quyen DV, Song LH, Van Thuan T, Tran TTT.	Front Microbiol	10.3389/fmicb.2024.1388740	2024
	Efficacy of the additional use of subgingival air-polishing with erythritol powder in the treatment of periodontitis patients: a randomized controlled clinical trial. Part II: effect on sub-gingival microbiome.	Mensi M, Caselli E, D'Accolti M, Soffritti I, Farina R, Scotti E, Guarnelli ME, Fabbri C, Garzetti G, Marchetti S, Sordillo A, Trombelli L.	Clin Oral Investig	10.1007/s00784-022-04811-4	2023
Genetics	The landscape of bacterial presence in tumor and adjacent normal tissue across 9 major cancer types using TCGA exome sequencing.	Rodriguez RM, Hernandez BY, Menor M, Deng Y, Khadka VS.	Comput Struct Biotechnol J	10.1016/j.csbj.2020.03.003	2020
Genetics	Genomic and taxonomic evaluation of 38 Treponema prophage sequences.	Ridgway R, Lu H, Blower TR, Evans NJ, Ainsworth S.	BMC Genomics	10.1186/s12864-024-10461-5	2024
Transcriptome	Whole-Transcriptome Sequencing Reveals Characteristics of Cancer Microbiome in Korean Patients with GI Tract Cancer: Fusobacterium nucleatum as a Therapeutic Target.	Ahn H, Min K, Lee E, Kim H, Kim S, Kim Y, Kim G, Cho B, Jeong C, Kim Y, Park H.	Microorganisms	10.3390/microorganisms10101896	2022
	Clinical and microbiological assessment in a subpopulation of young Argentine patients with severe periodontitis.	Pontarolo C, Bozza FL, Galli FG, Bonta H, Molgatini SL, Caride F, Gliosca LA.	Acta Odontol Latinoam	10.54589/aol.36/1/24	2023
Genetics	Shotgun metagenomic analysis of the oral microbiome in gingivitis: a nested case-control study.	Manzoor M, Leskela J, Pietiainen M, Martinez-Majander N, Kononen E, Niiranen T, Lahti L, Sinisalo J, Putaala J, Pussinen PJ, Paju S.	J Oral Microbiol	10.1080/20002297.2024.2330867	2024
	Detection and comparison of Selenomonas sputigena in subgingival biofilms in chronic and aggressive periodontitis patients.	Nagpal D, Prakash S, Bhat KG, Singh G.	J Indian Soc Periodontol	10.4103/0972-124x.181247	2016
	HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome.	Mann AE, Aumend C, Crull S, O'Connell LM, Osagie E, Akhigbe P, Obuekwe O, Omoigberale A, Rowe M, Blouin T, Soule A, Kelly C, DOMHaIN Study Team, Burne RA, Coker MO, Richards VP.	Microbiome	10.1186/s40168-025-02123-9	2025
	Detailed Characterization of the Lung-Gut Microbiome Axis Reveals the Link between PD-L1 and the Microbiome in Non-Small-Cell Lung Cancer Patients.	Ankudavicius V, Nikitina D, Lukosevicius R, Tilinde D, Salteniene V, Poskiene L, Miliauskas S, Skieceviciene J, Zemaitis M, Kupcinskas J.	Int J Mol Sci	10.3390/ijms25042323	2024
Proteome	Probing the salivary proteome for prognostic biomarkers in response to non-surgical periodontal therapy.	Silbereisen A, Bao K, Wolski W, Nanni P, Kunz L, Afacan B, Emingil G, Bostanci N.	J Clin Periodontol	10.1111/jcpe.13990	2025
	Veillonella parvula acts as a pathobiont promoting the biofilm virulence and cariogenicity of Streptococcus mutans in adult severe caries.	Wei Y, Zhang Y, Zhuang Y, Tang Y, Nie H, Haung Y, Liu T, Yang W, Yan F, Zhu Y.	Microbiol Spectr	10.1128/spectrum.04318-23	2024
Phylogeny	A comparison between full-length 16S rRNA Oxford nanopore sequencing and Illumina V3-V4 16S rRNA sequencing in head and neck cancer tissues.	Yeo K, Connell J, Bouras G, Smith E, Murphy W, Hodge JC, Krishnan S, Wormald PJ, Valentine R, Psaltis AJ, Vreugde S, Fenix KA.	Arch Microbiol	10.1007/s00203-024-03985-7	2024
	Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension.	Ren Y, Liang J, Hu W, Xie J, Zheng Y, Song W, Zhu J, Zhou H, Wu Q, He Y, Yin J.	J Oral Microbiol	10.1080/20002297.2024.2382620	2024
Phylogeny	Prediction of delayed graft function by early salivary microbiota following kidney transplantation.	Xiang X, Peng B, Liu K, Wang T, Ding P, Zhu Y, Cheng K, Ming Y, Ming Y.	Appl Microbiol Biotechnol	10.1007/s00253-024-13236-w	2024
	Nitrate and a nitrate-reducing Rothia aeria strain as potential prebiotic or synbiotic treatments for periodontitis.	Mazurel D, Carda-Dieguez M, Langenburg T, Ziemyte M, Johnston W, Martinez CP, Albalat F, Llena C, Al-Hebshi N, Culshaw S, Mira A, Rosier BT.	NPJ Biofilms Microbiomes	10.1038/s41522-023-00406-3	2023
	Quantification of Selenomonas sputigena in Chronic Periodontitis in Smokers Using 16S rDNA Based PCR Analysis.	Medikeri RS, Lele SV, Jain PM, Mali P, Medikeri MR.	J Clin Diagn Res	10.7860/jcdr/2015/12550.5782	2015
	Periodontal Molecular Diagnostics: State of Knowledge and Future Prospects for Clinical Application.	Dolinska E, Wisniewski P, Pietruska M.	Int J Mol Sci	10.3390/ijms252312624	2024
	Exploring the Potential of Oral Microbiome Biomarkers for Colorectal Cancer Diagnosis and Prognosis: A Systematic Review.	Negrut RL, Cote A, Maghiar AM.	Microorganisms	10.3390/microorganisms11061586	2023
	Activity of five antimicrobial peptides against periodontal as well as non-periodontal pathogenic strains.	Enigk K, Jentsch H, Rodloff AC, Eschrich K, Stingu CS.	J Oral Microbiol	10.1080/20002297.2020.1829405	2020
Phylogeny	Effect of cigarette smoking on subgingival bacteria in healthy subjects and patients with chronic periodontitis.	Karasneh JA, Al Habashneh RA, Marzouka NA, Thornhill MH.	BMC Oral Health	10.1186/s12903-017-0359-4	2017
	Gut Microbiota Reshapes the Tumor Microenvironment and Affects the Efficacy of Colorectal Cancer Immunotherapy.	Wang F, Chen W, Jia Y, He T, Wu S, Xiang J, Chen R, Jiang Q, Yu T, Lan Y, Li W, Ma L, He P, Li S.	Cancer Med	10.1002/cam4.70994	2025
	Microbiome of Saliva and Plaque in Children According to Age and Dental Caries Experience.	Lee E, Park S, Um S, Kim S, Lee J, Jang J, Jeong HO, Shin J, Kang J, Lee S, Jeong T.	Diagnostics (Basel)	10.3390/diagnostics11081324	2021
	Novel Pathogens in Periodontal Microbiology.	Hiranmayi KV, Sirisha K, Ramoji Rao MV, Sudhakar P.	J Pharm Bioallied Sci	10.4103/jpbs.jpbs_288_16	2017
	Newly identified pathogens in periodontitis: evidence from an association and an elimination study.	Veras EL, Castro Dos Santos N, Souza JGS, Figueiredo LC, Retamal-Valdes B, Barao VAR, Shibli J, Bertolini M, Faveri M, Teles F, Duarte P, Feres M.	J Oral Microbiol	10.1080/20002297.2023.2213111	2023
Phylogeny	Oral Dysbiosis in Severe Forms of Periodontitis Is Associated With Gut Dysbiosis and Correlated With Salivary Inflammatory Mediators: A Preliminary Study.	Kawamoto D, Borges R, Ribeiro RA, de Souza RF, Amado PPP, Saraiva L, Horliana ACRT, Faveri M, Mayer MPA.	Front Oral Health	10.3389/froh.2021.722495	2021
	Porphyromonas Gingivalis in the Development of Periodontitis: Impact on Dysbiosis and Inflammation.	Gasmi Benahmed A, Kumar Mujawdiya P, Noor S, Gasmi A.	Arch Razi Inst	10.22092/ari.2021.356596.1875	2022
	Surgical Prehabilitation in Patients with Gastrointestinal Cancers: Impact of Unimodal and Multimodal Programs on Postoperative Outcomes and Prospects for New Therapeutic Strategies-A Systematic Review.	Mareschal J, Hemmer A, Douissard J, Dupertuis YM, Collet TH, Koessler T, Toso C, Ris F, Genton L.	Cancers (Basel)	10.3390/cancers15061881	2023
	Analysis of symptomatic and asymptomatic primary root canal infections in adult Norwegian patients.	Rocas IN, Siqueira JF, Debelian GJ.	J Endod	10.1016/j.joen.2011.05.026	2011
	Antimicrobial Efficacy of Different Decontamination Methods as Tested on Dental Implants with Various Types of Surfaces.	Kubasiewicz-Ross P, Hadzik J, Gedrange T, Dominiak M, Jurczyszyn K, Pitulaj A, Nawrot-Hadzik I, Bortkiewicz O, Fleischer M.	Med Sci Monit	10.12659/msm.920513	2020
	Comparison of the in vivo antimicrobial effectiveness of sodium hypochlorite and chlorhexidine used as root canal irrigants: a molecular microbiology study.	Rocas IN, Siqueira JF.	J Endod	10.1016/j.joen.2010.11.006	2011
	Microbial and molecular differences according to the location of head and neck cancers.	Kim YK, Kwon EJ, Yu Y, Kim J, Woo SY, Choi HS, Kwon M, Jung K, Kim HS, Park HR, Lee D, Kim YH.	Cancer Cell Int	10.1186/s12935-022-02554-6	2022
Genetics	Reproducible and opposing gut microbiome signatures distinguish autoimmune diseases and cancers: a systematic review and meta-analysis.	Islam MZ, Tran M, Xu T, Tierney BT, Patel C, Kostic AD.	Microbiome	10.1186/s40168-022-01373-1	2022
Phylogeny	Levels of Candidate Periodontal Pathogens in Subgingival Biofilm.	Oliveira RR, Fermiano D, Feres M, Figueiredo LC, Teles FR, Soares GM, Faveri M.	J Dent Res	10.1177/0022034516634619	2016
	Oral microbiota populations of adult dogs consuming wet or dry foods.	Oba PM, Sieja KM, Keating SCJ, Hristova T, Somrak AJ, Swanson KS.	J Anim Sci	10.1093/jas/skac200	2022
Phylogeny	Metagenomic analysis of the salivary microbiota in patients with caries, periodontitis and comorbid diseases.	Shi C, Cai L, Xun Z, Zheng S, Shao F, Wang B, Zhu R, He Y.	J Dent Sci	10.1016/j.jds.2020.12.002	2021
Enzymology	Development of a polymerase chain reaction assay for the rapid detection of the oral pathogenic bacterium, Selenomonas noxia.	Cruz P, Mehretu AM, Buttner MP, Trice T, Howard KM.	BMC Oral Health	10.1186/s12903-015-0071-1	2015
	Microorganisms in root canal-treated teeth from a German population.	Rocas IN, Hulsmann M, Siqueira JF.	J Endod	10.1016/j.joen.2008.05.008	2008
Phylogeny	Salivary and fecal microbiota: potential new biomarkers for early screening of colorectal polyps.	Zhang L, Feng Z, Li Y, Lv C, Li C, Hu Y, Fu M, Song L.	Front Microbiol	10.3389/fmicb.2023.1182346	2023
	Microbiological diversity of generalized aggressive periodontitis by 16S rRNA clonal analysis.	Faveri M, Mayer MP, Feres M, de Figueiredo LC, Dewhirst FE, Paster BJ.	Oral Microbiol Immunol	10.1111/j.1399-302x.2007.00397.x	2008
	Distinguishing the dominant species of pathogen in ethmoidal sinusitis by sequencing DNA dataset analysis.	Zhang J, He S, Li Y, Lv M, Wei H, Qu B, Zheng Y, Hu C.	Exp Ther Med	10.3892/etm.2018.6726	2018
	Oral Microbiota Features in Subjects with Down Syndrome and Periodontal Diseases: A Systematic Review.	Contaldo M, Lucchese A, Romano A, Della Vella F, Di Stasio D, Serpico R, Serpico R, Petruzzi M.	Int J Mol Sci	10.3390/ijms22179251	2021
	Patterns of Oral Microbiota in Patients with Apical Periodontitis.	Korona-Glowniak I, Piatek D, Fornal E, Lukowiak A, Gerasymchuk Y, Kedziora A, Bugla-Ploskonska G, Grywalska E, Bachanek T, Malm A.	J Clin Med	10.3390/jcm10122707	2021
	The upper respiratory tract microbiota of healthy adults is affected by Streptococcus pneumoniae carriage, smoking habits, and contact with children.	Paulo AC, Lanca J, Almeida ST, Hilty M, Sa-Leao R.	Microbiome	10.1186/s40168-023-01640-9	2023
Phylogeny	Current understanding of the intratumoral microbiome in various tumors.	Xue C, Chu Q, Zheng Q, Yuan X, Su Y, Bao Z, Lu J, Li L.	Cell Rep Med	10.1016/j.xcrm.2022.100884	2023
	Tumour microbiomes and Fusobacterium genomics in Vietnamese colorectal cancer patients.	Tran HNH, Thu TNH, Nguyen PH, Vo CN, Doan KV, Nguyen Ngoc Minh C, Nguyen NT, Ta VND, Vu KA, Hua TD, Nguyen TNT, Van TT, Pham Duc T, Duong BL, Nguyen PM, Hoang VC, Pham DT, Pham DT, Thwaites GE, Hall LJ, Slade DJ, Baker S, Tran VH, Chung The H.	NPJ Biofilms Microbiomes	10.1038/s41522-022-00351-7	2022
Enzymology	Transitions in oral and gut microbiome of HPV+ oropharyngeal squamous cell carcinoma following definitive chemoradiotherapy (ROMA LA-OPSCC study).	Oliva M, Schneeberger PHH, Rey V, Cho M, Taylor R, Hansen AR, Taylor K, Hosni A, Bayley A, Hope AJ, Bratman SV, Ringash J, Singh S, Weinreb I, Perez-Ordonez B, Chepeha D, Waldron J, Xu W, Guttman D, Siu LL, Coburn B, Spreafico A.	Br J Cancer	10.1038/s41416-020-01253-1	2021
	Associations of the skin, oral and gut microbiome with aging, frailty and infection risk reservoirs in older adults.	Larson PJ, Zhou W, Santiago A, Driscoll S, Fleming E, Voigt AY, Chun OK, Grady JJ, Kuchel GA, Robison JT, Oh J.	Nat Aging	10.1038/s43587-022-00287-9	2022
Phylogeny	Identification of Salivary Microbiota and Its Association With Host Inflammatory Mediators in Periodontitis.	Lundmark A, Hu YOO, Huss M, Johannsen G, Andersson AF, Yucel-Lindberg T.	Front Cell Infect Microbiol	10.3389/fcimb.2019.00216	2019
	The composition of microbial communities in inflammatory periodontal diseases in young adults Tatars.	Kharitonova M, Vankov P, Abdrakhmanov A, Mamaeva E, Yakovleva G, Ilinskaya O.	AIMS Microbiol	10.3934/microbiol.2021005	2021
Genetics	Enrichment of oral-derived bacteria in inflamed colorectal tumors and distinct associations of Fusobacterium in the mesenchymal subtype.	Younginger BS, Mayba O, Reeder J, Nagarkar DR, Modrusan Z, Albert ML, Byrd AL.	Cell Rep Med	10.1016/j.xcrm.2023.100920	2023
	Differences in the subgingival microbiome according to stage of periodontitis: A comparison of two geographic regions.	Lafaurie GI, Neuta Y, Rios R, Pacheco-Montealegre M, Pianeta R, Castillo DM, Herrera D, Reyes J, Diaz L, Castillo Y, Sanz M, Iniesta M.	PLoS One	10.1371/journal.pone.0273523	2022
	Levels of Selenomonas species in generalized aggressive periodontitis.	Goncalves LF, Fermiano D, Feres M, Figueiredo LC, Teles FR, Mayer MP, Faveri M.	J Periodontal Res	10.1111/j.1600-0765.2012.01485.x	2012
	Non-Surgical Treatment of Periodontal Disease in a Pregnant Caucasian Women Population: Adverse Pregnancy Outcomes of a Randomized Clinical Trial.	Caneiro-Queija L, Lopez-Carral J, Martin-Lancharro P, Limeres-Posse J, Diz-Dios P, Blanco-Carrion J.	Int J Environ Res Public Health	10.3390/ijerph16193638	2019
	Removable denture is a risk indicator for peri-implantitis and facilitates expansion of specific periodontopathogens: a cross-sectional study.	Grischke J, Szafranski SP, Muthukumarasamy U, Haeussler S, Stiesch M.	BMC Oral Health	10.1186/s12903-021-01529-9	2021
	Effect of bovine milk fermented with Lactobacillus rhamnosus L8020 on periodontal disease in individuals with intellectual disability: a randomized clinical trial.	Yuki O, Furutani C, Mizota Y, Wakita A, Mimura S, Kihara T, Ohara M, Okada Y, Okada M, Nikawa H.	J Appl Oral Sci	10.1590/1678-7757-2018-0564	2019
Enzymology	Development of 16S rDNA-based PCR assay for detecting centipeda periodontii and selenomonas sputigena.	Sawada S, Kokeguchi S, Takashiba S, Murayama Y.	Lett Appl Microbiol	10.1046/j.1472-765x.2000.00735.x	2000
	The bacterial microbiome and metabolome in caries progression and arrest.	da Costa Rosa T, de Almeida Neves A, Azcarate-Peril MA, Divaris K, Wu D, Cho H, Moss K, Paster BJ, Chen T, B Freitas-Fernandes L, Fidalgo TKS, Tadeu Lopes R, Valente AP, R Arnold R, de Aguiar Ribeiro A.	J Oral Microbiol	10.1080/20002297.2021.1886748	2021
Metabolism	Cobalamin Riboswitches Are Broadly Sensitive to Corrinoid Cofactors to Enable an Efficient Gene Regulatory Strategy.	Kennedy KJ, Widner FJ, Sokolovskaya OM, Innocent LV, Procknow RR, Mok KC, Taga ME.	mBio	10.1128/mbio.01121-22	2022
	The Salivary Mycobiome Contains 2 Ecologically Distinct Mycotypes.	Hong BY, Hoare A, Cardenas A, Dupuy AK, Choquette L, Salner AL, Schauer PK, Hegde U, Peterson DE, Dongari-Bagtzoglou A, Strausbaugh LD, Diaz PI.	J Dent Res	10.1177/0022034520915879	2020
Genetics	Discriminating Microbial Community Structure Between Peri-Implantitis and Periodontitis With Integrated Metagenomic, Metatranscriptomic, and Network Analysis.	Komatsu K, Shiba T, Takeuchi Y, Watanabe T, Koyanagi T, Nemoto T, Shimogishi M, Shibasaki M, Katagiri S, Kasugai S, Iwata T.	Front Cell Infect Microbiol	10.3389/fcimb.2020.596490	2020
Phylogeny	Newly identified pathogens associated with periodontitis: a systematic review.	Perez-Chaparro PJ, Goncalves C, Figueiredo LC, Faveri M, Lobao E, Tamashiro N, Duarte P, Feres M.	J Dent Res	10.1177/0022034514542468	2014
	Gut microbiota and tumor-associated macrophages: potential in tumor diagnosis and treatment.	Zhou D, Li Y.	Gut Microbes	10.1080/19490976.2023.2276314	2023
	Gingival crevice microbiota from Chinese patients with gingivitis or necrotizing ulcerative gingivitis.	Gmur R, Wyss C, Xue Y, Thurnheer T, Guggenheim B.	Eur J Oral Sci	10.1111/j.0909-8836.2004.00103.x	2004
	Association of Oral Microbiome With Risk for Incident Head and Neck Squamous Cell Cancer.	Hayes RB, Ahn J, Fan X, Peters BA, Ma Y, Yang L, Agalliu I, Burk RD, Ganly I, Purdue MP, Freedman ND, Gapstur SM, Pei Z.	JAMA Oncol	10.1001/jamaoncol.2017.4777	2018
Phylogeny	Phylogenetic characterization of Centipeda periodontii, Selenomonas sputigena and Selenomonas species by 16S rRNA gene sequence analysis.	Sawada S, Kokeguchi S, Nishimura F, Takashiba S, Murayama Y.	Microbios		1999
Phylogeny	Subgingival microbiota levels and their associations with periodontal status at the sampled sites in an adult Sudanese population using miswak or toothbrush regularly.	Darout IA, Skaug N, Albandar JM.	Acta Odontol Scand	10.1080/00016350310002784	2003
	Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration.	Yang Z, Liang X, Jiang X, Guo J, Tao Y, Wang S, Cao Y, Gui S.	Molecules	10.3390/molecules23092275	2018
	Correlations between bacterial levels in autologous subgingival plaque and saliva of adult Sudanese.	Darout IA, Albandar JM, Skaug N.	Clin Oral Investig	10.1007/s00784-002-0177-0	2002
	R/G Value-A Numeric Index of Individual Periodontal Health and Oral Microbiome Dynamics.	Najmanova L, Sabova L, Lenartova M, Janatova T, Mysak J, Vetrovsky T, Tesinska B, Balikova Novotna G, Koberska M, Broukal Z, Duskova J, Podzimek S, Janata J.	Front Cell Infect Microbiol	10.3389/fcimb.2021.602643	2021
	Electronic Cigarette Use Promotes a Unique Periodontal Microbiome.	Thomas SC, Xu F, Pushalkar S, Lin Z, Thakor N, Vardhan M, Flaminio Z, Khodadadi-Jamayran A, Vasconcelos R, Akapo A, Queiroz E, Bederoff M, Janal MN, Guo Y, Aguallo D, Gordon T, Corby PM, Kamer AR, Li X, Saxena D.	mBio	10.1128/mbio.00075-22	2022
Enzymology	The Application of Magnetic Bead Selection to Investigate Interactions between the Oral Microbiota and Salivary Immunoglobulins.	Madhwani T, McBain AJ.	PLoS One	10.1371/journal.pone.0158288	2016
	Chemical and biological properties of lipopolysaccharide from Selenomonas sputigena ATCC 33150.	Kumada H, Watanabe K, Nakamu A, Haishima Y, Kondo S, Hisatsune K, Umemoto T.	Oral Microbiol Immunol	10.1111/j.1399-302x.1997.tb00373.x	1997
	Dysbiosis in chronic periodontitis: Key microbial players and interactions with the human host.	Deng ZL, Szafranski SP, Jarek M, Bhuju S, Wagner-Dobler I.	Sci Rep	10.1038/s41598-017-03804-8	2017
	Oral microbiota and host innate immune response in bisphosphonate-related osteonecrosis of the jaw.	Pushalkar S, Li X, Kurago Z, Ramanathapuram LV, Matsumura S, Fleisher KE, Glickman R, Yan W, Li Y, Saxena D.	Int J Oral Sci	10.1038/ijos.2014.46	2014
	Profile of subgingival microbiota in children with mixed dentition.	Kamma JJ, Diamanti-Kipioti A, Nakou M, Mitsis FJ.	Oral Microbiol Immunol	10.1034/j.1399-302x.2000.150206.x	2000
Enzymology	Association of early onset periodontitis microbiota with aspartate aminotransferase activity in gingival crevicular fluid.	Kamma JJ, Nakou M, Persson RG.	J Clin Periodontol	10.1034/j.1600-051x.2001.281203.x	2001
Phylogeny	Partial denture metal framework may harbor potentially pathogenic bacteria.	Mengatto CM, Marchini L, Bernardes LA, Gomes SC, Silva AM, Rizzatti-Barbosa CM, Rizzatti-Barbosa CM.	J Adv Prosthodont	10.4047/jap.2015.7.6.468	2015
	Salivary bacterial fingerprints of established oral disease revealed by the Human Oral Microbe Identification using Next Generation Sequencing (HOMINGS) technique.	Belstrom D, Paster BJ, Fiehn NE, Bardow A, Holmstrup P.	J Oral Microbiol	10.3402/jom.v8.30170	2016
	Profile of subgingival microbiota in children with primary dentition.	Kamma JJ, Diamanti-Kipioti A, Nakou M, Mitsis FJ.	J Periodontal Res	10.1034/j.1600-0765.2000.035001033.x	2000
Phylogeny	Subgingival microflora associated with nifedipine-induced gingival overgrowth.	Nakou M, Kamma JJ, Andronikaki A, Mitsis F.	J Periodontol	10.1902/jop.1998.69.6.664	1998
Metabolism	New players in the same old game: a system level in silico study to predict type III secretion system and effector proteins in bacterial genomes reveals common themes in T3SS mediated pathogenesis.	Sadarangani V, Datta S, Arunachalam M.	BMC Res Notes	10.1186/1756-0500-6-297	2013
	Adverse effects of electronic cigarettes on the disease-naive oral microbiome.	Ganesan SM, Dabdoub SM, Nagaraja HN, Scott ML, Pamulapati S, Berman ML, Shields PG, Wewers ME, Kumar PS.	Sci Adv	10.1126/sciadv.aaz0108	2020
Metabolism	Identification of an apiosyltransferase in the plant pathogen Xanthomonas pisi.	Smith JA, Bar-Peled M.	PLoS One	10.1371/journal.pone.0206187	2018
	Metagenome-genome-wide association studies reveal human genetic impact on the oral microbiome.	Liu X, Tong X, Zhu J, Tian L, Jie Z, Zou Y, Lin X, Liang H, Li W, Ju Y, Qin Y, Zou L, Lu H, Zhu S, Jin X, Xu X, Yang H, Wang J, Zong Y, Liu W, Hou Y, Jia H, Zhang T.	Cell Discov	10.1038/s41421-021-00356-0	2021
	Clinical and microbiological characteristics of smokers with early onset periodontitis.	Kamma JJ, Nakou M, Baehni PC.	J Periodontal Res	10.1111/j.1600-0765.1999.tb02218.x	1999
Enzymology	Fatal septicaemia with Selenomonas sputigena and Acinetobacter calcoaceticus. A case report.	Westh H, Christensen JJ, Blom J, Frederiksen W.	APMIS	10.1111/j.1699-0463.1991.tb05121.x	1991
	Subgingival microflora in smokers with early onset periodontitis.	Kamma JJ, Nakou M.	Anaerobe	10.1006/anae.1997.0095	1997
Genetics	White-spot lesions and gingivitis microbiotas in orthodontic patients.	Tanner AC, Sonis AL, Lif Holgerson P, Starr JR, Nunez Y, Kressirer CA, Paster BJ, Johansson I.	J Dent Res	10.1177/0022034512455031	2012
	Keystone Species in Pregnancy Gingivitis: A Snapshot of Oral Microbiome During Pregnancy and Postpartum Period.	Balan P, Chong YS, Umashankar S, Swarup S, Loke WM, Lopez V, He HG, Seneviratne CJ.	Front Microbiol	10.3389/fmicb.2018.02360	2018
	Adherence of oral microorganisms to guided tissue membranes: an in vitro study.	Wang HL, Yuan K, Burgett F, Shyr Y, Syed S.	J Periodontol	10.1902/jop.1994.65.3.211	1994
	The relationship between gingivitis and the serum antibodies to the microbiota associated with periodontal disease in children with Down's syndrome.	Morinushi T, Lopatin DE, Van Poperin N.	J Periodontol	10.1902/jop.1997.68.7.626	1997
	Xylitol and sorbitol effects on the microbiome of saliva and plaque.	Rafeek R, Carrington CVF, Gomez A, Harkins D, Torralba M, Kuelbs C, Addae J, Moustafa A, Nelson KE.	J Oral Microbiol	10.1080/20002297.2018.1536181	2019
	Bacterial adherence to guided tissue regeneration barrier membranes exposed to the oral environment.	Chen YT, Wang HL, Lopatin DE, O'Neal R, MacNeil RL.	J Periodontol	10.1902/jop.1997.68.2.172	1997
	Sex-specific differences in the salivary microbiome of caries-active children.	Ortiz S, Herrman E, Lyashenko C, Purcell A, Raslan K, Khor B, Snow M, Forsyth A, Choi D, Maier T, Machida CA.	J Oral Microbiol	10.1080/20002297.2019.1653124	2019
Pathogenicity	In vitro activity of meropenem compared with imipenem, metronidazole, ampicillin, and ampicillin/sulbactam against anaerobes.	Schumacher U, Manncke B, Gerbracht K, Werner H.	Arzneimittelforschung		1994
Metabolism	Aspartame as a source of essential phenylalanine for the growth of oral anaerobes.	Wyss C.	FEMS Microbiol Lett	10.1111/j.1574-6968.1993.tb06111.x	1993
	Microbiota of rapidly progressive periodontitis lesions in association with clinical parameters.	Kamma JJ, Nakou M, Manti FA.	J Periodontol	10.1902/jop.1994.65.11.1073	1994
Pathogenicity	Susceptibility of anaerobic microorganisms to hypothiocyanite produced by lactoperoxidase.	Courtois P, Majerus P, Labbe M, Vanden Abbeele A, Yourassowsky E, Pourtois M.	Acta Stomatol Belg		1992
	Associations between microbial species in dental root canal infections.	Sundqvist G.	Oral Microbiol Immunol	10.1111/j.1399-302x.1992.tb00584.x	1992
Pathogenicity	Members of the Oral Microbiota Are Associated with IL-8 Release by Gingival Epithelial Cells in Healthy Individuals.	Schueller K, Riva A, Pfeiffer S, Berry D, Somoza V.	Front Microbiol	10.3389/fmicb.2017.00416	2017
Enzymology	Fatal Selenomonas sputigena septicemia probably originating from lung abscess.	Pinon G, Grollier G, Romet-Lemonne JL, de Rautlin de la Roy Y.	Eur J Clin Microbiol	10.1007/bf02013666	1985
	Microbial community succession on developing lesions on human enamel.	Torlakovic L, Klepac-Ceraj V, Ogaard B, Cotton SL, Paster BJ, Olsen I.	J Oral Microbiol	10.3402/jom.v4i0.16125	2012
Phylogeny	Identification of Selenomonas species by whole-genomic DNA probes, sodium dodecyl sulfate-polyacrylamide gel electrophoresis, biochemical tests and cellular fatty acid analysis.	Maiden MF, Tanner A, Moore WE.	Oral Microbiol Immunol	10.1111/j.1399-302x.1992.tb00012.x	1992
	Preservation of the metaproteome: variability of protein preservation in ancient dental calculus.	Mackie M, Hendy J, Lowe AD, Sperduti A, Holst M, Collins MJ, Speller CF.	Sci Technol Archaeol Res	10.1080/20548923.2017.1361629	2017
Metabolism	The presence of bacteria within tissue provides insights into the pathogenesis of oral lichen planus.	Choi YS, Kim Y, Yoon HJ, Baek KJ, Alam J, Park HK, Choi Y.	Sci Rep	10.1038/srep29186	2016
	Deep metaproteomic analysis of human salivary supernatant.	Jagtap P, McGowan T, Bandhakavi S, Tu ZJ, Seymour S, Griffin TJ, Rudney JD.	Proteomics	10.1002/pmic.201100503	2012
Phylogeny	Comparison of oral microbiota in tumor and non-tumor tissues of patients with oral squamous cell carcinoma.	Pushalkar S, Ji X, Li Y, Estilo C, Yegnanarayana R, Singh B, Li X, Saxena D.	BMC Microbiol	10.1186/1471-2180-12-144	2012
Phylogeny	Accurate genome relative abundance estimation for closely related species in a metagenomic sample.	Sohn MB, An L, Pookhao N, Li Q.	BMC Bioinformatics	10.1186/1471-2105-15-242	2014
Phylogeny	Use of multiple-displacement amplification and checkerboard DNA-DNA hybridization to examine the microbiota of endodontic infections.	Brito LC, Teles FR, Teles RP, Franca EC, Ribeiro-Sobrinho AP, Haffajee AD, Socransky SS.	J Clin Microbiol	10.1128/jcm.02618-06	2007
Pathogenicity	Antibiotic susceptibilities of periodontal bacteria. In vitro susceptibilities to eight antimicrobial agents.	Walker CB, Pappas JD, Tyler KZ, Cohen S, Gordon JM.	J Periodontol	10.1902/jop.1985.56.11s.67	1985
Phylogeny	Bacterial profiles of root caries in elderly patients.	Preza D, Olsen I, Aas JA, Willumsen T, Grinde B, Paster BJ.	J Clin Microbiol	10.1128/jcm.02411-07	2008
Enzymology	Selenomonas sputigena septicemia.	McCarthy LR, Carlson JR.	J Clin Microbiol	10.1128/jcm.14.6.684-685.1981	1981
	Clinical, microbiological and immunological features associated with the treatment of active periodontosis lesions.	Haffajee AD, Socransky SS, Ebersole JL, Smith DJ.	J Clin Periodontol	10.1111/j.1600-051x.1984.tb00913.x	1984
	Ultrasonic dispersion of pure cultures of plaque bacteria and plaque.	Olsen I, Socransky SS.	Scand J Dent Res	10.1111/j.1600-0722.1981.tb01687.x	1981
	An approach to the definition of periodontal disease syndromes by cluster analysis.	Socransky SS, Tanner AC, Goodson JM, Haffajee AD, Walker CB, Ebersole JL, Sornberger GC.	J Clin Periodontol	10.1111/j.1600-051x.1982.tb02107.x	1982
Phylogeny	API ZYM and API An-Ident reactions of fastidious oral gram-negative species.	Tanner AC, Strzempko MN, Belsky CA, McKinley GA.	J Clin Microbiol	10.1128/jcm.22.3.333-335.1985	1985
	Microbiota of gingivitis in man.	Slots J, Moenbo D, Langebaek J, Frandsen A.	Scand J Dent Res	10.1111/j.1600-0722.1978.tb01929.x	1978
	Phylogenetic identification of bacterial MazF toxin protein motifs among probiotic strains and foodborne pathogens and potential implications of engineered probiotic intervention in food.	Yan X, Gurtler JB, Fratamico PM, Hu J, Juneja VK.	Cell Biosci	10.1186/2045-3701-2-39	2012
Phylogeny	Molecular identification of microorganisms from endodontic infections.	Rolph HJ, Lennon A, Riggio MP, Saunders WP, MacKenzie D, Coldero L, Bagg J.	J Clin Microbiol	10.1128/jcm.39.9.3282-3289.2001	2001
Phylogeny	characterization of bacterial community diversity in cystic fibrosis lung infections by use of 16s ribosomal DNA terminal restriction fragment length polymorphism profiling.	Rogers GB, Carroll MP, Serisier DJ, Hockey PM, Jones G, Bruce KD.	J Clin Microbiol	10.1128/jcm.42.11.5176-5183.2004	2004
	Polyclonal B-cell activation induced by extracts of Gram-negative bacteria isolated from periodontally diseased sites.	Bick PH, Carpenter AB, Holdeman LV, Miller GA, Ranney RR, Palcanis KG, Tew JG.	Infect Immun	10.1128/iai.34.1.43-49.1981	1981
Cultivation	Medium for selective isolation of Fusobacterium nucleatum from human periodontal pockets.	Walker CB, Ratliff D, Muller D, Mandell R, Socransky SS.	J Clin Microbiol	10.1128/jcm.10.6.844-849.1979	1979
Metabolism	First insights into the syntrophic acetate-oxidizing bacteria--a genetic study.	Muller B, Sun L, Schnurer A.	Microbiologyopen	10.1002/mbo3.50	2013
Phylogeny	Bacterial diversity in human subgingival plaque.	Paster BJ, Boches SK, Galvin JL, Ericson RE, Lau CN, Levanos VA, Sahasrabudhe A, Dewhirst FE.	J Bacteriol	10.1128/jb.183.12.3770-3783.2001	2001
	A consortium of Aggregatibacter actinomycetemcomitans, Streptococcus parasanguinis, and Filifactor alocis is present in sites prior to bone loss in a longitudinal study of localized aggressive periodontitis.	Fine DH, Markowitz K, Fairlie K, Tischio-Bereski D, Ferrendiz J, Furgang D, Paster BJ, Dewhirst FE.	J Clin Microbiol	10.1128/jcm.00729-13	2013
	Lack of in vitro and in vivo recognition of Francisella tularensis subspecies lipopolysaccharide by Toll-like receptors.	Hajjar AM, Harvey MD, Shaffer SA, Goodlett DR, Sjostedt A, Edebro H, Forsman M, Bystrom M, Pelletier M, Wilson CB, Miller SI, Skerrett SJ, Ernst RK.	Infect Immun	10.1128/iai.00934-06	2006
	Coaggregation of Fusobacterium nucleatum, Selenomonas flueggei, Selenomonas infelix, Selenomonas noxia, and Selenomonas sputigena with strains from 11 genera of oral bacteria.	Kolenbrander PE, Andersen RN, Moore LV.	Infect Immun	10.1128/iai.57.10.3194-3203.1989	1989
	Compact liquid nitrogen storage system yielding high recoveries of gram-negative anaerobes.	Gilmour MN, Turner G, Berman RG, Krenzer AK.	Appl Environ Microbiol	10.1128/aem.35.1.84-88.1978	1978
Phylogeny	Microbial biomarkers of common tongue coatings in patients with gastric cancer.	Xu J, Xiang C, Zhang C, Xu B, Wu J, Wang R, Yang Y, Shi L, Zhang J, Zhan Z	Microb Pathog	10.1016/j.micpath.2018.11.051	2018
	Megasphaera lornae sp. nov., Megasphaera hutchinsoni sp. nov., and Megasphaera vaginalis sp. nov.: novel bacteria isolated from the female genital tract.	Srinivasan S, Beamer MA, Fiedler TL, Austin MN, Sizova MV, Strenk SM, Agnew KJ, Gowda GAN, Raftery D, Epstein SS, Fredricks DN, Hillier SL.	Int J Syst Evol Microbiol	10.1099/ijsem.0.004702	2019