Thermotoga maritima (DSM 3109, JCM 10099, MSB8)

Name: Thermotoga maritima (DSM 3109, JCM 10099, MSB8)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 17060

Type strain

Strain Designation MSB8

Culture col. no. DSM 3109 JCM 10099 MSB8 NBRC 100826 ATCC 43589

NCBI tax ID(s) 243274 2336

Special Collections DSMZ JCM

History <- K. O. Stetter, Univ. Regensburg, Germany; MSB8 <- K. O. Stetter; {1982} DSM 3109 <-- K. O. Stetter MSB8.

Links

Thermotoga maritima MSB8 is an anaerobe bacterium that was isolated from anaerobic marine mud.

anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 41926

ATCC 43589,DSM 3109,JCM 10099,NBRC 100826

@ref 20215

Last LPSN update 2026-02-09 11:22:07

Domain Bacteria

Phylum Thermotogota

Class Thermotogae

Order Thermotogales

Family Thermotogaceae

Genus Thermotoga

Species Thermotoga maritima

Full scientific name Thermotoga maritima Stetter and Huber 1986

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
1306	THERMOTOGA NEAPOLITANA MEDIUM (DSMZ Medium 343)		Medium recipe at MediaDive	Name: THERMOTOGA NEAPOLITANA MEDIUM (DSMZ Medium 343) Composition: NaCl 6.87686 g/l Starch 4.96524 g/l Yeast extract 1.9861 g/l MgSO4 x 7 H2O 1.73784 g/l MgCl2 x 6 H2O 1.36544 g/l CaCl2 x 2 H2O 0.55859 g/l KH2PO4 0.496524 g/l Na2S x 9 H2O 0.496524 g/l L-Cysteine HCl x H2O 0.496524 g/l KCl 0.16137 g/l NaBr 0.0248262 g/l Nitrilotriacetic acid 0.0223436 g/l MnSO4 x H2O 0.00744786 g/l H3BO3 0.00744786 g/l SrCl2 x 6 H2O 0.00372393 g/l ZnSO4 x 7 H2O 0.00268123 g/l CoSO4 x 7 H2O 0.00268123 g/l Citric acid 0.00248262 g/l FeSO4 x 7 H2O 0.00148957 g/l Sodium resazurin 0.000496524 g/l NiCl2 x 6 H2O 0.000446872 g/l AlK(SO4)2 x 12 H2O 0.000297915 g/l CuSO4 x 5 H2O 0.000148957 g/l Na2MoO4 x 2 H2O 0.000148957 g/l Pyridoxine hydrochloride 9.93049e-05 g/l p-Aminobenzoic acid 4.96524e-05 g/l Riboflavin 4.96524e-05 g/l (DL)-alpha-Lipoic acid 4.96524e-05 g/l Thiamine HCl 4.96524e-05 g/l Calcium D-(+)-pantothenate 4.96524e-05 g/l Nicotinic acid 4.96524e-05 g/l Folic acid 1.9861e-05 g/l Biotin 1.9861e-05 g/l KI 1.24131e-05 g/l Na2WO4 x 2 H2O 5.95829e-06 g/l Na2SeO3 x 5 H2O 4.46872e-06 g/l Vitamin B12 9.93049e-07 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)
1306	positive	growth	80
67770	positive	growth	80

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
1306	anaerobe
125438	anaerobe	90.865
125439	anaerobe	98.8

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	CDP-diacylglycerol biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	sulfopterin metabolism	100	4 of 4
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	ppGpp biosynthesis	100	4 of 4
66794	anapleurotic synthesis of oxalacetate	100	1 of 1
66794	folate polyglutamylation	100	1 of 1
66794	palmitate biosynthesis	95.45	21 of 22
66794	pentose phosphate pathway	90.91	10 of 11
66794	starch degradation	90	9 of 10
66794	threonine metabolism	90	9 of 10
66794	chorismate metabolism	88.89	8 of 9
66794	peptidoglycan biosynthesis	86.67	13 of 15
66794	NAD metabolism	83.33	15 of 18
66794	cellulose degradation	80	4 of 5
66794	photosynthesis	78.57	11 of 14
66794	valine metabolism	77.78	7 of 9
66794	d-mannose degradation	77.78	7 of 9
66794	vitamin B1 metabolism	76.92	10 of 13
66794	glycogen biosynthesis	75	3 of 4
66794	isoleucine metabolism	75	6 of 8
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	flavin biosynthesis	73.33	11 of 15
66794	methionine metabolism	73.08	19 of 26
66794	glycolysis	70.59	12 of 17
66794	purine metabolism	70.21	66 of 94
66794	Entner Doudoroff pathway	70	7 of 10
66794	pyrimidine metabolism	68.89	31 of 45
66794	degradation of sugar alcohols	68.75	11 of 16
66794	glutamate and glutamine metabolism	67.86	19 of 28
66794	serine metabolism	66.67	6 of 9
66794	aspartate and asparagine metabolism	66.67	6 of 9
66794	acetoin degradation	66.67	2 of 3
66794	octane oxidation	66.67	2 of 3
66794	enterobactin biosynthesis	66.67	2 of 3
66794	formaldehyde oxidation	66.67	2 of 3
66794	glycolate and glyoxylate degradation	66.67	4 of 6
66794	isoprenoid biosynthesis	65.38	17 of 26
66794	tetrahydrofolate metabolism	64.29	9 of 14
66794	d-xylose degradation	63.64	7 of 11
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	62.5	5 of 8
66794	gluconeogenesis	62.5	5 of 8
66794	ketogluconate metabolism	62.5	5 of 8
66794	phenylalanine metabolism	61.54	8 of 13
66794	degradation of hexoses	61.11	11 of 18
66794	degradation of pentoses	60.71	17 of 28
66794	lipoate biosynthesis	60	3 of 5
66794	metabolism of amino sugars and derivatives	60	3 of 5
66794	glycogen metabolism	60	3 of 5
66794	hydrogen production	60	3 of 5
66794	histidine metabolism	58.62	17 of 29
66794	ubiquinone biosynthesis	57.14	4 of 7
66794	citric acid cycle	57.14	8 of 14
66794	oxidative phosphorylation	57.14	52 of 91
66794	cysteine metabolism	55.56	10 of 18
66794	urea cycle	53.85	7 of 13
66794	tryptophan metabolism	52.63	20 of 38
66794	alanine metabolism	51.72	15 of 29
66794	ethanol fermentation	50	1 of 2
66794	CMP-KDO biosynthesis	50	2 of 4
66794	lactate fermentation	50	2 of 4
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	acetate fermentation	50	2 of 4
66794	suberin monomers biosynthesis	50	1 of 2
66794	pantothenate biosynthesis	50	3 of 6
66794	arginine metabolism	50	12 of 24
66794	glycine metabolism	50	5 of 10
66794	adipate degradation	50	1 of 2
66794	butanoate fermentation	50	2 of 4
66794	ribulose monophosphate pathway	50	1 of 2
66794	lysine metabolism	50	21 of 42
66794	propionate fermentation	50	5 of 10
66794	non-pathway related	47.37	18 of 38
66794	leucine metabolism	46.15	6 of 13
66794	metabolism of disaccharids	45.45	5 of 11
66794	CO2 fixation in Crenarchaeota	44.44	4 of 9
66794	degradation of sugar acids	44	11 of 25
66794	reductive acetyl coenzyme A pathway	42.86	3 of 7
66794	propanol degradation	42.86	3 of 7
66794	cardiolipin biosynthesis	42.86	3 of 7
66794	tyrosine metabolism	42.86	6 of 14
66794	degradation of aromatic, nitrogen containing compounds	41.67	5 of 12
66794	creatinine degradation	40	2 of 5
66794	coenzyme M biosynthesis	40	4 of 10
66794	myo-inositol biosynthesis	40	4 of 10
66794	chlorophyll metabolism	38.89	7 of 18
66794	lipid metabolism	38.71	12 of 31
66794	dTDPLrhamnose biosynthesis	37.5	3 of 8
66794	proline metabolism	36.36	4 of 11
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	nitrate assimilation	33.33	3 of 9
66794	cyanate degradation	33.33	1 of 3
66794	IAA biosynthesis	33.33	1 of 3
66794	lipid A biosynthesis	33.33	3 of 9
66794	selenocysteine biosynthesis	33.33	2 of 6
66794	ascorbate metabolism	31.82	7 of 22
66794	phenylpropanoid biosynthesis	30.77	4 of 13
66794	sulfate reduction	30.77	4 of 13
66794	vitamin B6 metabolism	27.27	3 of 11
66794	polyamine pathway	26.09	6 of 23
66794	vitamin E metabolism	25	1 of 4
66794	biotin biosynthesis	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	phosphatidylethanolamine bioynthesis	23.08	3 of 13
66794	molybdenum cofactor biosynthesis	22.22	2 of 9
66794	glutathione metabolism	21.43	3 of 14

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Aquatic	#Marine
#Environmental	#Terrestrial	#Mud (Sludge)
#Condition	#Anoxic (anaerobic)	-

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
1306	anaerobic marine mud	Vulcano island	Italy	ITA	Europe
67770	Geothermally heated sea sediment	Porto di Levante, Vulcano	Italy	ITA	Europe

Taxonmaps

69479

Global distribution of 16S sequence M21774 (>99% sequence identity) for Thermotoga from Microbeatlas

Aquatic Samples	246
Soil Samples	93
Animal Samples	428
Plant Samples	10
Total Samples	777

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
1306	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	Thermotoga maritima MSB8	complete		243274.18		243274	99.8
66792	ASM39026v1 assembly for Thermotoga maritima MSB8	complete	GCA_000390265	243274.17	2554235387	243274	99.34
66792	ASM97855v1 assembly for Thermotoga maritima MSB8	complete	GCA_000978555	243274.19	2687453609	243274	99.34
66792	ASM23065v3 assembly for Thermotoga maritima MSB8	complete	GCA_000230655	243274.49	2519899531	243274	99.33
66792	ASM854v1 assembly for Thermotoga maritima MSB8	complete	GCA_000008545	243274.5	637000321	243274	98.77

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
1306	T.maritima ribosomal RNA small subunit	M21774	1562		2336

GC content

@ref	GC-content (mol%)	Method
1306	46.0
67770	46	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Thermotoga maritima MSB8
NCBI: GCA_000390265

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	52.90	no
125439	motility	BacteriaNetⓘ	no	52.90	no
125439	gram_stain	BacteriaNetⓘ	variable	76.30	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	98.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Thermotoga maritima MSB8 MSB8
NCBI: GCA_000230655.3

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	65.35	no
125438	anaerobic	anaerobicⓘ	yes	90.87	yes
125438	aerobic	aerobicⓘ	no	92.99	yes
125438	spore-forming	spore-formingⓘ	no	72.00	no
125438	thermophilic	thermophileⓘ	yes	81.93	no
125438	flagellated	motile2+ⓘ	yes	58.95	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Kinetics and products of Thermotoga maritima beta-glucosidase with lactose and cellobiose.	Ten Kate GA, Sanders P, Dijkhuizen L, van Leeuwen SS.	Appl Microbiol Biotechnol	10.1007/s00253-024-13183-6	2024
	Metabolic engineering of Caldicellulosiruptor bescii for hydrogen production.	Cha M, Kim JK, Lee WH, Song H, Lee TG, Kim SK, Kim SJ.	Appl Microbiol Biotechnol	10.1007/s00253-023-12974-7	2024
	Novel transaminases from thermophiles: from discovery to application.	Cardenas-Fernandez M, Sinclair O, Ward JM.	Microb Biotechnol	10.1111/1751-7915.13940	2022
Enzymology	A Cytoplasmic NAD(P)H-Dependent Polysulfide Reductase with Thiosulfate Reductase Activity from the Hyperthermophilic Bacterium Thermotoga maritima.	Liang J, Huang H, Wang Y, Li L, Yi J, Wang S.	Microbiol Spectr	10.1128/spectrum.00436-22	2022
Lipids	Changes in the Distribution of Membrane Lipids during Growth of Thermotoga maritima at Different Temperatures: Indications for the Potential Mechanism of Biosynthesis of Ether-Bound Diabolic Acid (Membrane-Spanning) Lipids.	Sahonero-Canavesi DX, Villanueva L, Bale NJ, Bosviel J, Koenen M, Hopmans EC, Sinninghe Damste JS.	Appl Environ Microbiol	10.1128/aem.01763-21	2022
	Data on a thermostable enzymatic one-pot reaction for the production of a high-value compound from l-arabinose.	Bawn M, Subrizi F, Lye GJ, Sheppard TD, Hailes HC, Ward JM.	Data Brief	10.1016/j.dib.2018.05.140	2018
	Occurrence of Capnophilic Lactic Fermentation in the Hyperthermophilic Anaerobic Bacterium Thermotoga sp. Strain RQ7.	Esercizio N, Lanzilli M, Landi S, Caso L, Xu Z, Nuzzo G, Gallo C, Manzo E, Esposito S, Fontana A, d'Ippolito G.	Int J Mol Sci	10.3390/ijms231912049	2022
	Biological Routes for Biohydrogen Production: A Clean and Carbon-Free Fuel.	Cha M, Park MS, Kim SJ.	Biotechnol J	10.1002/biot.70074	2025
Metabolism	Mechanism of Thermal Adaptation in the Lactate Dehydrogenases.	Peng HL, Egawa T, Chang E, Deng H, Callender R.	J Phys Chem B	10.1021/acs.jpcb.5b09909	2015
	Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima.	Frock AD, Montero CI, Blumer-Schuette SE, Kelly RM.	Appl Environ Microbiol	10.1128/aem.01627-13	2013
Metabolism	Characterization of a thioredoxin-thioredoxin reductase system from the hyperthermophilic bacterium Thermotoga maritima.	Yang X, Ma K.	J Bacteriol	10.1128/jb.01035-09	2010
Metabolism	Cheese whey to biohydrogen and useful organic acids: A non-pathogenic microbial treatment by L. acidophilus.	Pandey A, Srivastava S, Rai P, Duke M.	Sci Rep	10.1038/s41598-019-42752-3	2019
	Genes for the major structural components of Thermotogales species' togas revealed by proteomic and evolutionary analyses of OmpA and OmpB homologs.	Petrus AK, Swithers KS, Ranjit C, Wu S, Brewer HM, Gogarten JP, Pasa-Tolic L, Noll KM.	PLoS One	10.1371/journal.pone.0040236	2012
Enzymology	Hyperthermostable acetyl xylan esterase.	Drzewiecki K, Angelov A, Ballschmiter M, Tiefenbach KJ, Sterner R, Liebl W.	Microb Biotechnol	10.1111/j.1751-7915.2009.00150.x	2010
Metabolism	The iron-hydrogenase of Thermotoga maritima utilizes ferredoxin and NADH synergistically: a new perspective on anaerobic hydrogen production.	Schut GJ, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.01582-08	2009
Metabolism	Xylanase attachment to the cell wall of the hyperthermophilic bacterium Thermotoga maritima.	Liebl W, Winterhalter C, Baumeister W, Armbrecht M, Valdez M.	J Bacteriol	10.1128/jb.01149-07	2008
Genetics	Transcriptional regulation of the carbohydrate utilization network in Thermotoga maritima.	Rodionov DA, Rodionova IA, Li X, Ravcheev DA, Tarasova Y, Portnoy VA, Zengler K, Osterman AL.	Front Microbiol	10.3389/fmicb.2013.00244	2013
Metabolism	Genus-Wide Assessment of Lignocellulose Utilization in the Extremely Thermophilic Genus Caldicellulosiruptor by Genomic, Pangenomic, and Metagenomic Analyses.	Lee LL, Blumer-Schuette SE, Izquierdo JA, Zurawski JV, Loder AJ, Conway JM, Elkins JG, Podar M, Clum A, Jones PC, Piatek MJ, Weighill DA, Jacobson DA, Adams MWW, Kelly RM.	Appl Environ Microbiol	10.1128/aem.02694-17	2018
Enzymology	Tyrosine latching of a regulatory gate affords allosteric control of aromatic amino acid biosynthesis.	Cross PJ, Dobson RC, Patchett ML, Parker EJ.	J Biol Chem	10.1074/jbc.m110.209924	2011
Phylogeny	Universal architecture of bacterial chemoreceptor arrays.	Briegel A, Ortega DR, Tocheva EI, Wuichet K, Li Z, Chen S, Muller A, Iancu CV, Murphy GE, Dobro MJ, Zhulin IB, Jensen GJ.	Proc Natl Acad Sci U S A	10.1073/pnas.0905181106	2009
Metabolism	Molecular and biochemical characterization of the thermoactive family 1 pectate lyase from the hyperthermophilic bacterium Thermotoga maritima.	Kluskens LD, van Alebeek GJ, Voragen AG, de Vos WM, van der Oost J.	Biochem J	10.1042/bj20021595	2003
Metabolism	Part II: defining and quantifying individual and co-cultured intracellular proteomes of two thermophilic microorganisms by GeLC-MS2 and spectral counting.	Andrews G, Lewis D, Notey J, Kelly R, Muddiman D.	Anal Bioanal Chem	10.1007/s00216-010-3929-8	2010
Enzymology	Characterization of a thermostable L-arabinose (D-galactose) isomerase from the hyperthermophilic eubacterium Thermotoga maritima.	Lee DW, Jang HJ, Choe EA, Kim BC, Lee SJ, Kim SB, Hong YH, Pyun YR.	Appl Environ Microbiol	10.1128/aem.70.3.1397-1404.2004	2004
	Characterization of Di-myo-Inositol-1,1(prm1)-Phosphate in the Hyperthermophilic Bacterium Thermotoga maritima.	Ramakrishnan V, Verhagen M, Adams M.	Appl Environ Microbiol	10.1128/aem.63.1.347-350.1997	1997
Enzymology	The hyperthermophilic bacterium Thermotoga maritima has two different classes of family C DNA polymerases: evolutionary implications.	Huang YP, Ito J.	Nucleic Acids Res	10.1093/nar/26.23.5300	1998
	Properties and gene structure of the Thermotoga maritima alpha-amylase AmyA, a putative lipoprotein of a hyperthermophilic bacterium.	Liebl W, Stemplinger I, Ruile P.	J Bacteriol	10.1128/jb.179.3.941-948.1997	1997
	Two Extremely Thermostable Xylanases of the Hyperthermophilic Bacterium Thermotoga maritima MSB8.	Winterhalter C, Liebl W.	Appl Environ Microbiol	10.1128/aem.61.5.1810-1815.1995	1995
Enzymology	Purification and characterization of two extremely thermostable enzymes, phosphate acetyltransferase and acetate kinase, from the hyperthermophilic eubacterium Thermotoga maritima.	Bock AK, Glasemacher J, Schmidt R, Schonheit P.	J Bacteriol	10.1128/jb.181.6.1861-1867.1999	1999
	Thiosulfate reduction, an important physiological feature shared by members of the order thermotogales.	Ravot G, Ollivier B, Magot M, Patel B, Crolet J, Fardeau M, Garcia J.	Appl Environ Microbiol	10.1128/aem.61.5.2053-2055.1995	1995
Enzymology	Reverse gyrase in thermophilic eubacteria.	Bouthier de la Tour C, Portemer C, Huber R, Forterre P, Duguet M.	J Bacteriol	10.1128/jb.173.12.3921-3923.1991	1991
	Transcriptional analysis of biofilm formation processes in the anaerobic, hyperthermophilic bacterium Thermotoga maritima.	Pysz MA, Conners SB, Montero CI, Shockley KR, Johnson MR, Ward DE, Kelly RM.	Appl Environ Microbiol	10.1128/aem.70.10.6098-6112.2004	2004
Enzymology	Purification of Thermotoga maritima enzymes for the degradation of cellulosic materials.	Bronnenmeier K, Kern A, Liebl W, Staudenbauer WL.	Appl Environ Microbiol	10.1128/aem.61.4.1399-1407.1995	1995
Enzymology	Octameric enolase from the hyperthermophilic bacterium Thermotoga maritima: purification, characterization, and image processing.	Schurig H, Rutkat K, Rachel R, Jaenicke R.	Protein Sci	10.1002/pro.5560040209	1995
	The unique chaperone operon of Thermotoga maritima: cloning and initial characterization of a functional Hsp70 and small heat shock protein.	Michelini ET, Flynn GC.	J Bacteriol	10.1128/jb.181.14.4237-4244.1999	1999
Enzymology	The DNA-dependent RNA-polymerase of Thermotoga maritima; characterisation of the enzyme and the DNA-sequence of the genes for the large subunits.	Palm P, Schleper C, Arnold-Ammer I, Holz I, Meier T, Lottspeich F, Zillig W.	Nucleic Acids Res	10.1093/nar/21.21.4904	1993
Metabolism	Reductive precipitation of gold by dissimilatory Fe(III)-reducing bacteria and archaea.	Kashefi K, Tor JM, Nevin KP, Lovley DR.	Appl Environ Microbiol	10.1128/aem.67.7.3275-3279.2001	2001
Enzymology	Reverse gyrase from the hyperthermophilic bacterium Thermotoga maritima: properties and gene structure.	Bouthier de la Tour C, Portemer C, Kaltoum H, Duguet M.	J Bacteriol	10.1128/jb.180.2.274-281.1998	1998
	Phylogenetic depth of S10 and spc operons: cloning and sequencing of a ribosomal protein gene cluster from the extremely thermophilic bacterium Thermotoga maritima.	Sanangelantoni AM, Bocchetta M, Cammarano P, Tiboni O.	J Bacteriol	10.1128/jb.176.24.7703-7710.1994	1994
Phylogeny	Discontinuous occurrence of the hsp70 (dnaK) gene among Archaea and sequence features of HSP70 suggest a novel outlook on phylogenies inferred from this protein.	Gribaldo S, Lumia V, Creti R, Conway de Macario E, Sanangelantoni A, Cammarano P.	J Bacteriol	10.1128/jb.181.2.434-443.1999	1999
Enzymology	Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.	Kletzin A, Adams MW.	J Bacteriol	10.1128/jb.178.1.248-257.1996	1996
	Keratin Degradation by Fervidobacterium pennavorans, a Novel Thermophilic Anaerobic Species of the Order Thermotogales.	Friedrich AB, Antranikian G.	Appl Environ Microbiol	10.1128/aem.62.8.2875-2882.1996	1996
Enzymology	B12-dependent ribonucleotide reductases from deeply rooted eubacteria are structurally related to the aerobic enzyme from Escherichia coli.	Jordan A, Torrents E, Jeanthon C, Eliasson R, Hellman U, Wernstedt C, Barbe J, Gibert I, Reichard P.	Proc Natl Acad Sci U S A	10.1073/pnas.94.25.13487	1997
Pathogenicity	Ribosomes of the extremely thermophilic eubacterium Thermotoga maritima are uniquely insensitive to the miscoding-inducing action of aminoglycoside antibiotics.	Londei P, Altamura S, Huber R, Stetter KO, Cammarano P.	J Bacteriol	10.1128/jb.170.9.4353-4360.1988	1988
	Phosphoglycerate kinase and triosephosphate isomerase from the hyperthermophilic bacterium Thermotoga maritima form a covalent bifunctional enzyme complex.	Schurig H, Beaucamp N, Ostendorp R, Jaenicke R, Adler E, Knowles JR.	EMBO J	10.1002/j.1460-2075.1995.tb07020.x	1995
Enzymology	Reverse gyrase, a hallmark of the hyperthermophilic archaebacteria.	Bouthier de la Tour C, Portemer C, Nadal M, Stetter KO, Forterre P, Duguet M.	J Bacteriol	10.1128/jb.172.12.6803-6808.1990	1990
Metabolism	Posttranscriptional modification of tRNA in thermophilic archaea (Archaebacteria).	Edmonds CG, Crain PF, Gupta R, Hashizume T, Hocart CH, Kowalak JA, Pomerantz SC, Stetter KO, McCloskey JA.	J Bacteriol	10.1128/jb.173.10.3138-3148.1991	1991
	Characterization of UDP amino sugars as major phosphocompounds in the hyperthermophilic archaeon Pyrococcus furiosus.	Ramakrishnan V, Teng Q, Adams MW.	J Bacteriol	10.1128/jb.179.5.1505-1512.1997	1997
	Bacterial syntenies: an exact approach with gene quorum.	Denielou YP, Sagot MF, Boyer F, Viari A.	BMC Bioinformatics	10.1186/1471-2105-12-193	2011
Enzymology	Thermostable cellobiohydrolase from the thermophilic eubacterium Thermotoga sp. strain FjSS3-B.1. Purification and properties.	Ruttersmith LD, Daniel RM.	Biochem J	10.1042/bj2770887	1991
Metabolism	Linking genome content to biofuel production yields: a meta-analysis of major catabolic pathways among select H2 and ethanol-producing bacteria.	Carere CR, Rydzak T, Verbeke TJ, Cicek N, Levin DB, Sparling R.	BMC Microbiol	10.1186/1471-2180-12-295	2012
	The sequence of the single 16S rRNA gene of the thermophilic eubacterium Rhodothermus marinus reveals a distant relationship to the group containing Flexibacter, Bacteroides, and Cytophaga species.	Andresson OS, Fridjonsson OH.	J Bacteriol	10.1128/jb.176.20.6165-6169.1994	1994
Metabolism	The glucuronic acid utilization gene cluster from Bacillus stearothermophilus T-6.	Shulami S, Gat O, Sonenshein AL, Shoham Y.	J Bacteriol	10.1128/jb.181.12.3695-3704.1999	1999
	Compilation of small ribosomal subunit RNA structures.	Neefs JM, Van de Peer Y, De Rijk P, Chapelle S, De Wachter R.	Nucleic Acids Res	10.1093/nar/21.13.3025	1993
	Structure and function of a beta-1,2-galactosidase from Bacteroides xylanisolvens, an intestinal bacterium.	Nakazawa Y, Kageyama M, Matsuzawa T, Liang Z, Kobayashi K, Shimizu H, Maeda K, Masuhiro M, Motouchi S, Kumano S, Tanaka N, Kuramochi K, Nakai H, Taguchi H, Nakajima M.	Commun Biol	10.1038/s42003-025-07494-1	2025
	Genomic analysis of Oceanotoga teriensis strain UFV_LIMV02, a multidrug-resistant thermophilic bacterium isolated from an offshore oil reservoir.	Santos AJDC, Dias RS, da Silva CHM, Vidigal PMP, de Sousa MP, da Silva CC, de Paula SO.	Access Microbiol	10.1099/acmi.0.000801.v3	2024
	L-rhamnose isomerase: a crucial enzyme for rhamnose catabolism and conversion of rare sugars.	Yoshida H, Izumori K, Yoshihara A.	Appl Microbiol Biotechnol	10.1007/s00253-024-13325-w	2024
	Man/Cel5B, a Bifunctional Enzyme Having the Highest Mannanase Activity in the Hyperthermic Environment.	Sadaqat B, Sha C, Rupani PF, Wang H, Zuo W, Shao W.	Front Bioeng Biotechnol	10.3389/fbioe.2021.637649	2021
	Structural and Functional Analyses of the Transcription Repressor DgoR From Escherichia coli Reveal a Divalent Metal-Containing D-Galactonate Binding Pocket.	Lin Z, Sun Y, Liu Y, Tong S, Shang Z, Cai Y, Lin W.	Front Microbiol	10.3389/fmicb.2020.590330	2020
	Characterization of a recombinant thermostable l-rhamnose isomerase from Thermotoga maritima ATCC 43589 and its application in the production of l-lyxose and l-mannose	Park CS, Yeom SJ, Lim YR, Kim YS, Oh DK.	Biotechnol Lett		2010
Enzymology	Site-Directed Mutagenesis of a Hyperthermophilic Endoglucanase Cel12B from Thermotoga maritima Based on Rational Design.	Zhang J, Shi H, Xu L, Zhu X, Li X.	PLoS One	10.1371/journal.pone.0133824	2015
	Synergistic enhancement of cellulase pairs linked by consensus ankyrin repeats: Determination of the roles of spacing, orientation, and enzyme identity.	Cunha ES, Hatem CL, Barrick D.	Proteins	10.1002/prot.25047	2016
Metabolism	An Aromatic Cap Seals the Substrate Binding Site in an ECF-Type S Subunit for Riboflavin.	Karpowich NK, Song J, Wang DN.	J Mol Biol	10.1016/j.jmb.2016.06.003	2016
	Large-Scale Molecular Evolutionary Analysis Uncovers a Variety of Polynucleotide Kinase Clp1 Family Proteins in the Three Domains of Life.	Saito M, Sato A, Nagata S, Tamaki S, Tomita M, Suzuki H, Kanai A.	Genome Biol Evol	10.1093/gbe/evz195	2019
	Insertion of endocellulase catalytic domains into thermostable consensus ankyrin scaffolds: effects on stability and cellulolytic activity.	Cunha ES, Hatem CL, Barrick D.	Appl Environ Microbiol	10.1128/aem.02121-13	2013
Enzymology	The purification, crystallization and preliminary X-ray diffraction analysis of two isoforms of meso-diaminopimelate decarboxylase from Arabidopsis thaliana.	Oliver MR, Crowther JM, Leeman MM, Kessans SA, North RA, Donovan KA, Griffin MD, Suzuki H, Hudson AO, Kasanmascheff M, Dobson RC.	Acta Crystallogr F Struct Biol Commun	10.1107/s2053230x14007699	2014
	In silico method for modelling metabolism and gene product expression at genome scale.	Lerman JA, Hyduke DR, Latif H, Portnoy VA, Lewis NE, Orth JD, Schrimpe-Rutledge AC, Smith RD, Adkins JN, Zengler K, Palsson BO.	Nat Commun	10.1038/ncomms1928	2012
Metabolism	Stabilized homoserine o-succinyltransferases (MetA) or L-methionine partially recovers the growth defect in Escherichia coli lacking ATP-dependent proteases or the DnaK chaperone.	Mordukhova EA, Kim D, Pan JG.	BMC Microbiol	10.1186/1471-2180-13-179	2013
Enzymology	A general method for rapid and nondenaturing purification of RNAs.	Kieft JS, Batey RT.	RNA	10.1261/rna.7040604	2004
Metabolism	D-Amino acid dipeptide production utilizing D-alanine-D-alanine ligases with novel substrate specificity.	Sato M, Kirimura K, Kino K	J Biosci Bioeng	10.1263/jbb.99.623	2005
	Characterisation of a hyperthermophilic transketolase from Thermotoga maritima DSM3109 as a biocatalyst for 7-keto-octuronic acid synthesis.	Cardenas-Fernandez M, Subrizi F, Dobrijevic D, Hailes HC, Ward JM	Org Biomol Chem	10.1039/d1ob01237a	2021
Metabolism	Ligands of thermophilic ABC transporters encoded in a newly sequenced genomic region of Thermotoga maritima MSB8 screened by differential scanning fluorimetry.	Boucher N, Noll KM	Appl Environ Microbiol	10.1128/AEM.05418-11	2011
Enzymology	Structure-based modification of D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589 for depsipeptide synthesis.	Nakagawa T, Satake R, Sato M, Kino K	Biosci Biotechnol Biochem	10.1271/bbb.100832	2011
Enzymology	Characterization of a recombinant thermostable L: -rhamnose isomerase from Thermotoga maritima ATCC 43589 and its application in the production of L-lyxose and L-mannose.	Park CS, Yeom SJ, Lim YR, Kim YS, Oh DK	Biotechnol Lett	10.1007/s10529-010-0385-7	2010
Metabolism	Enhancement of the alcoholytic activity of alpha-amylase AmyA from Thermotoga maritima MSB8 (DSM 3109) by site-directed mutagenesis.	Damian-Almazo JY, Moreno A, Lopez-Munguia A, Soberon X, Gonzalez-Munoz F, Saab-Rincon G	Appl Environ Microbiol	10.1128/AEM.00121-08	2008
Enzymology	Thermostable ATP regeneration system using polyphosphate kinase from Thermosynechococcus elongatus BP-1 for D-amino acid dipeptide synthesis.	Sato M, Masuda Y, Kirimura K, Kino K	J Biosci Bioeng	10.1263/jbb.103.179	2007
Enzymology	Substrate specificity of thermostable D-alanine-D-alanine ligase from Thermotoga maritima ATCC 43589.	Sato M, Kirimura K, Kino K	Biosci Biotechnol Biochem	10.1271/bbb.60307	2006
Enzymology	[Expression and purification of thermostable alpha-glucuronidase from Thermotoga maritima].	Xue YM, Mao ZG, Shao WL	Sheng Wu Gong Cheng Xue Bao		2004
Metabolism	Analysis of a Thermotoga maritima DNA fragment encoding two similar thermostable cellulases, CelA and CelB, and characterization of the recombinant enzymes.	Liebl W, Ruile P, Bronnenmeier K, Riedel K, Lottspeich F, Greif I	Microbiology (Reading)	10.1099/00221287-142-9-2533	1996
	Thermocrinis ruber gen. nov., sp. nov., A pink-filament-forming hyperthermophilic bacterium isolated from yellowstone national park	Huber R, Eder W, Heldwein S, Wanner G, Huber H, Rachel R, Stetter KO.	Appl Environ Microbiol	10.1128/aem.64.10.3576-3583.1998	1998

References

#1306	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 3109
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Thermotoga maritima (DSM 3109, JCM 10099, MSB8)

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