Bifidobacterium bifidum (DSM 20082, JCM 1254, E319f (Variant a))

Name: Bifidobacterium bifidum (DSM 20082, JCM 1254, E319f (Variant a))
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 1691

Type strain

Strain Designation E319f (Variant a), 319f

Culture col. no. DSM 20082 JCM 1254 E319f (Variant a) KCTC 3440 CIP 64.64 3 more

NCBI tax ID(s) 398514 1681

Special Collections DSMZ JCM KCTC CIP CCUG

History <- G. Reuter, E319f (Variant a) DSM 20082 <-- G. Reuter E319f (Variant a). CIP <- 1964, Lab. Ident. Inst. Pasteur, Paris, France <- M. Sebald, Inst. Pasteur, Paris, France <- H. Werner <- G. Reuter: strain 319f

Links

Bifidobacterium bifidum E319f is an anaerobe, Gram-positive, rod-shaped bacterium that was isolated from intestine of adult.

Gram-positive rod-shaped anaerobe genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 7403

LMG 13201,DSM 20082,JCM 1254,LMG 11582,CCUG 45218,CCRC 11844,CIP 64.64,KCTC 3440,BCRC 11844

@ref 20215

Last LPSN update 2026-02-09 11:18:09

Domain Bacteria

Phylum Actinomycetota

Class Actinomycetes

Order Bifidobacteriales

Family Bifidobacteriaceae

Genus Bifidobacterium

Species Bifidobacterium bifidum

Full scientific name Bifidobacterium bifidum (Tissier 1900) Orla-Jensen 1924 (Approved Lists 1980)

Synonyms (2)

"Bacillus bifidus"
"Bacterium bifidum"

BacDive ID	Other strains from **Bifidobacterium bifidum** (23)	Type strain
1693	B. bifidum Ti, Tissier, DSM 20456, ATCC 29521, JCM 1255, ... (type strain)
1690	B. bifidum Hl 3, DSM 20215
1692	B. bifidum 212A, DSM 20239, ATCC 11863, JCM 1209, NCDO ...
137143	B. bifidum S28a, CIP 64.65, ATCC 15696, NCDO 2203, CCUG ...
138906	B. bifidum Am, CIP 63.78, ATCC 11618
144562	B. bifidum CCUG 25687
151330	B. bifidum CCUG 43775
151925	B. bifidum CCUG 45218, CIP 64.64
155871	B. bifidum CCUG 59492
162513	B. bifidum JCM 19472
162514	B. bifidum JCM 19473
162515	B. bifidum JCM 19474
162516	B. bifidum JCM 19475
162518	B. bifidum JCM 19477
162519	B. bifidum JCM 19478
162520	B. bifidum JCM 19479
162522	B. bifidum JCM 19481
162523	B. bifidum JCM 19482
162524	B. bifidum JCM 19483
162525	B. bifidum JCM 19484
165447	B. bifidum JCM 7002
165448	B. bifidum JCM 7003
174364	B. bifidum HUN437, Calf96, DSM 115838

Morphology

Cell morphology

@ref	Gram stain	Cell shape	Motility	Confidence
116807	positive	rod-shaped
125438				96

Culture and growth conditions

Culture medium

@ref	Name	Medium link	Composition
8509	BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58)	Medium recipe at MediaDive	Name: BIFIDOBACTERIUM MEDIUM (DSMZ Medium 58) Composition: Glucose 10.0 g/l Casein peptone 10.0 g/l Bacto Soytone 5.0 g/l Meat extract 5.0 g/l Yeast extract 5.0 g/l L-Cysteine HCl x H2O 0.5 g/l NaHCO3 0.4 g/l NaCl 0.08 g/l MnSO4 x H2O 0.05 g/l KH2PO4 0.04 g/l K2HPO4 0.04 g/l MgSO4 x 7 H2O 0.02 g/l CaCl2 x 2 H2O 0.01 g/l Tween 80 Resazurin Distilled water
36043	MEDIUM 20 - for Anaerobic bacteria		Agar (15.000 g);Glucose (5.000 g);Yeast extract (20.000 g);Tryptone (30.000 g);Cysteine hydrochloride (0.500 g);distilled water (1000.000 ml);Hemin solution -M00149 (25.000 ml)
116807	CIP Medium 72	Medium recipe at CIP
116807	CIP Medium 20	Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
8509	positive	growth	37
36043	positive	growth	37
67770	positive	growth	37

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance
8509	anaerobe
116807	anaerobe

Spore formation

@ref	Spore formation	Confidence
125438		91.266
125439		96.6

Murein

@ref	Murein short key	Type
8509	A21.08	A4ß L-Orn(L-Lys)-D-Ser-D-Asp

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	-	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
116807	17632 ChEBI	nitrate	-	reduction
116807	16301 ChEBI	nitrite	-	reduction
68371		Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

Metabolite production

@ref	Chebi-ID	Metabolite	Production
116807	35581 ChEBI	indole

Enzymes

@ref	Value	Activity	Ec
68382	acid phosphatase	+	3.1.3.2	from API zym
68382	alkaline phosphatase	-	3.1.3.1	from API zym
68382	alpha-chymotrypsin	-	3.4.21.1	from API zym
68382	alpha-fucosidase	-	3.2.1.51	from API zym
68382	alpha-galactosidase	+	3.2.1.22	from API zym
68382	alpha-glucosidase	-	3.2.1.20	from API zym
68382	alpha-mannosidase	-	3.2.1.24	from API zym
68382	beta-galactosidase	+	3.2.1.23	from API zym
68382	beta-glucosidase	-	3.2.1.21	from API zym
68382	beta-glucuronidase	-	3.2.1.31	from API zym
116807	catalase	-	1.11.1.6
68382	cystine arylamidase	-	3.4.11.3	from API zym
68382	esterase (C 4)	+		from API zym
68382	esterase lipase (C 8)	+		from API zym
68382	leucine arylamidase	+	3.4.11.1	from API zym
68382	lipase (C 14)	-		from API zym
68382	N-acetyl-beta-glucosaminidase	+	3.2.1.52	from API zym
68382	naphthol-AS-BI-phosphohydrolase	-		from API zym
116807	oxidase	-
68382	trypsin	-	3.4.21.4	from API zym
116807	urease	-	3.5.1.5
68382	valine arylamidase	-		from API zym

API zym

@ref	Control	Alkaline phosphatase	Esterase (C 4)	2-naphtyl caprylateEsterase Lipase (C 8)	Lipase (C 14)	L-leucyl-2-naphthylamideLeucine arylamidase	L-valyl-2-naphthylamideValine arylamidase	L-cystyl-2-naphthylamideCystine arylamidase	Trypsin	alpha- Chymotrypsin	Acid phosphatase	Naphthol-AS-BI-phosphateNaphthol-AS-BI-phosphohydrolase	alpha- Galactosidase	beta- Galactosidase	beta- Glucuronidase	alpha- Glucosidase	beta- Glucosidase	N-acetyl-beta- glucosaminidase	alpha- Mannosidase	alpha- Fucosidase
116807	-	-	+	+	-	+	-	-	-	-	+	-	+	+	-	-	-	+	-	-

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
116807	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+/-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	+/-

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2
#Host Body-Site	#Gastrointestinal tract

Isolation

@ref	Sample type
8509	intestine of adult
67770	Intestine of adult
116807	Human, Intestine of adult

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
8509	1	Risk group (German classification) According to TRBA 466
116807	1	Risk group (French classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	NCBI tax ID	Score	IMG accession
66792	ASM2434174v1 assembly for Bifidobacterium bifidum JCM 1254	contig	GCA_024341745	398514.7	398514	65.19
67770	ASM131170v1 assembly for Bifidobacterium bifidum JCM 1254	contig	GCA_001311705	398514.4	398514		2675903332

16S sequences

@ref	Description	Accession	Length	NCBI tax ID
20218	Bifidobacterium bifidum gene for 16S rRNA, partial sequence, strain: JCM 1254	AB116282	478	398514
20218	Bifidobacterium bifidum gene for 16S rRNA, partial sequence, strain: JCM 1254	AB507077	687	398514
20218	Bifidobacterium bifidum strain DSM 20082 16S ribosomal RNA gene and 16S-23S ribosomal RNA intergenic spacer, partial sequence	JQ347258	743	1681

GC content

@ref	GC-content (mol%)	Method
8509	61.6
67770	61.1	thermal denaturation, midpoint method (Tm)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Bifidobacterium bifidum JCM 1254
NCBI: GCA_001311705

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	96.60	no
125439	motility	BacteriaNetⓘ	no	52.60	no
125439	gram_stain	BacteriaNetⓘ	positive	85.00	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	80.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Bifidobacterium bifidum JCM 1254
PATRIC: 398514.4

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	yes	86.85	no
125438	anaerobic	anaerobicⓘ	yes	78.07	no
125438	spore-forming	spore-formingⓘ	no	91.27	no
125438	aerobic	aerobicⓘ	no	90.10	no
125438	thermophilic	thermophileⓘ	no	93.97	yes
125438	flagellated	motile2+ⓘ	no	96.00	no

Literature

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	Potential Health Benefits of Ropy Exopolysaccharides Produced by Lactobacillus plantarum.	Yilmaz T, Simsek O.	Molecules	10.3390/molecules25143293	2020
Metabolism	In Vitro Prebiotic and Anti-Colon Cancer Activities of Agar-Derived Sugars from Red Seaweeds.	Yun EJ, Yu S, Kim YA, Liu JJ, Kang NJ, Jin YS, Kim KH.	Mar Drugs	10.3390/md19040213	2021
Genetics	Resource sharing of an infant gut microbiota synthetic community in combinations of human milk oligosaccharides.	Ioannou A, Berkhout MD, Scott WT, Blijenberg B, Boeren S, Mank M, Knol J, Belzer C.	ISME J	10.1093/ismejo/wrae209	2024
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Genetics	Probiotic Lactobacillus and Bifidobacterium strains possess safety characteristics, antiviral activities and host adherence factors revealed by genome mining.	Abdelhamid AG, El-Masry SS, El-Dougdoug NK, El-Dougdoug NK.	EPMA J	10.1007/s13167-019-00184-z	2019
Metabolism	Complementary Mechanisms for Degradation of Inulin-Type Fructans and Arabinoxylan Oligosaccharides among Bifidobacterial Strains Suggest Bacterial Cooperation.	Riviere A, Selak M, Geirnaert A, Van den Abbeele P, De Vuyst L.	Appl Environ Microbiol	10.1128/aem.02893-17	2018
Enzymology	Highly efficient chemoenzymatic synthesis of beta1-3-linked galactosides.	Yu H, Thon V, Lau K, Cai L, Chen Y, Mu S, Li Y, Wang PG, Chen X.	Chem Commun (Camb)	10.1039/c0cc02850a	2010
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Metabolism	Novel putative galactose operon involving lacto-N-biose phosphorylase in Bifidobacterium longum.	Kitaoka M, Tian J, Nishimoto M.	Appl Environ Microbiol	10.1128/aem.71.6.3158-3162.2005	2005
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Metabolism	Structure and evolution of the bifidobacterial carbohydrate metabolism proteins and enzymes.	Fushinobu S, Abou Hachem M.	Biochem Soc Trans	10.1042/bst20200163	2021
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	Impact of different organic acids on heat-moisture treated potato starch for enhancing prebiotic potential.	Yu SJ, Lee KY, Lee HG.	Food Sci Biotechnol	10.1007/s10068-024-01575-3	2024
Biotechnology	Recent advances in the science of human milk oligosaccharides	Urashima T, Ajisaka K, Ujihara T, Nakazaki E.	BBA Adv		2025
	In vitro competition with Bifidobacterium strains impairs potentially pathogenic growth of Clostridium perfringens on 2'-fucosyllactose.	Nakajima A, Arzamasov AA, Sakanaka M, Murakami R, Kozakai T, Yoshida K, Katoh T, Ojima MN, Hirose J, Nagao S, Xiao JZ, Odamaki T, Rodionov DA, Katayama T.	Gut Microbes	10.1080/19490976.2025.2478306	2025
	Molecular Insights Into O-Linked Glycan Utilization by Gut Microbes.	Gonzalez-Morelo KJ, Vega-Sagardia M, Garrido D.	Front Microbiol	10.3389/fmicb.2020.591568	2020
Metabolism	Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with Bifidobacteria-Rich Microbiota Formation.	Sakanaka M, Gotoh A, Yoshida K, Odamaki T, Koguchi H, Xiao JZ, Kitaoka M, Katayama T.	Nutrients	10.3390/nu12010071	2019
	Carotenoid productivity in human intestinal bacteria Eubacterium limosum and Leuconostoc mesenteroides with functional analysis of their carotenoid biosynthesis genes.	Matsumoto W, Takemura M, Nanaura H, Ami Y, Maoka T, Shindo K, Kurihara S, Misawa N.	Eng Microbiol	10.1016/j.engmic.2024.100147	2024
Metabolism	The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors.	Sato M, Liebschner D, Yamada Y, Matsugaki N, Arakawa T, Wills SS, Hattie M, Stubbs KA, Ito T, Senda T, Ashida H, Fushinobu S.	J Biol Chem	10.1074/jbc.m117.777391	2017
	The Interaction Between Viruses and Intestinal Microbiota: A Review.	Lv Z, Xiong D, Shi J, Long M, Chen Z.	Curr Microbiol	10.1007/s00284-021-02623-5	2021
	A Bacterial beta1-3-Galactosyltransferase Enables Multigram-Scale Synthesis of Human Milk Lacto-N-tetraose (LNT) and Its Fucosides.	McArthur JB, Yu H, Chen X.	ACS Catal	10.1021/acscatal.9b03990	2019
Metabolism	An F-type lectin domain directs the activity of Streptosporangium roseum alpha-l-fucosidase.	Bishnoi R, Mahajan S, Ramya TNC.	Glycobiology	10.1093/glycob/cwy079	2018
Genetics	A simple method that enhances minority species detection in the microbiota: 16S metagenome-DRIP (Deeper Resolution using an Inhibitory Primer).	Nakajima A, Yoshida K, Gotoh A, Katoh T, Ojima MN, Sakanaka M, Xiao JZ, Odamaki T, Katayama T.	Microbiome Res Rep	10.20517/mrr.2022.08	2022
	A novel bacterial beta-N-acetyl glucosaminidase from Chitinolyticbacter meiyuanensis possessing transglycosylation and reverse hydrolysis activities.	Zhang A, Mo X, Zhou N, Wang Y, Wei G, Chen J, Chen K, Ouyang P.	Biotechnol Biofuels	10.1186/s13068-020-01754-4	2020
	1,6-alpha-L-Fucosidases from Bifidobacterium longum subsp. infantis ATCC 15697 Involved in the Degradation of Core-fucosylated N -Glycan.	Ashida H, Fujimoto T, Kurihara S, Nakamura M, Komeno M, Huang Y, Katayama T, Kinoshita T, Takegawa K.	J Appl Glycosci (1999)	10.5458/jag.jag.jag-2019_0016	2020
Enzymology	Synthesis of Fucosyl-Oligosaccharides Using alpha-l-Fucosidase from Lactobacillus rhamnosus GG.	Escamilla-Lozano Y, Guzman-Rodriguez F, Alatorre-Santamaria S, Garcia-Garibay M, Gomez-Ruiz L, Rodriguez-Serrano G, Cruz-Guerrero A.	Molecules	10.3390/molecules24132402	2019
	Screening Microbial Interactions During Inulin Utilization Reveals Strong Competition and Proteomic Changes in Lacticaseibacillus paracasei M38.	Vega-Sagardia M, Cabezon EC, Delgado J, Ruiz-Moyano S, Garrido D.	Probiotics Antimicrob Proteins	10.1007/s12602-023-10083-5	2024
Metabolism	Metabolism of four alpha-glycosidic linkage-containing oligosaccharides by Bifidobacterium breve UCC2003.	O'Connell KJ, O'Connell Motherway M, O'Callaghan J, Fitzgerald GF, Ross RP, Ventura M, Stanton C, van Sinderen D.	Appl Environ Microbiol	10.1128/aem.01775-13	2013
	Determining the metabolic fate of human milk oligosaccharides: it may just be more complex than you think?	Jackson PPJ, Wijeyesekera A, Rastall RA.	Gut Microbiome (Camb)	10.1017/gmb.2022.8	2022
Metabolism	Comparative transcriptomics reveals key differences in the response to milk oligosaccharides of infant gut-associated bifidobacteria.	Garrido D, Ruiz-Moyano S, Lemay DG, Sela DA, German JB, Mills DA.	Sci Rep	10.1038/srep13517	2015
	Utilization of Host-Derived Glycans by Intestinal Lactobacillus and Bifidobacterium Species.	Zuniga M, Monedero V, Yebra MJ.	Front Microbiol	10.3389/fmicb.2018.01917	2018
Metabolism	Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis.	Fang J, Wang H, Zhou Y, Zhang H, Zhou H, Zhang X.	Exp Mol Med	10.1038/s12276-021-00617-8	2021
Metabolism	Cross-feeding by Bifidobacterium breve UCC2003 during co-cultivation with Bifidobacterium bifidum PRL2010 in a mucin-based medium.	Egan M, Motherway MO, Kilcoyne M, Kane M, Joshi L, Ventura M, van Sinderen D.	BMC Microbiol	10.1186/s12866-014-0282-7	2014
Proteome	Proteinaceous Molecules Mediating Bifidobacterium-Host Interactions.	Ruiz L, Delgado S, Ruas-Madiedo P, Margolles A, Sanchez B.	Front Microbiol	10.3389/fmicb.2016.01193	2016
Enzymology	Sialidases from gut bacteria: a mini-review.	Juge N, Tailford L, Owen CD.	Biochem Soc Trans	10.1042/bst20150226	2016
	Mucin glycan foraging in the human gut microbiome.	Tailford LE, Crost EH, Kavanaugh D, Juge N.	Front Genet	10.3389/fgene.2015.00081	2015
	Protein-Linked Glycan Degradation in Infants Fed Human Milk.	Dallas DC, Sela D, Underwood MA, German JB, Lebrilla C.	J Glycomics Lipidomics	10.4172/2153-0637.s1-002	2012
Metabolism	Novel alpha-L-Fucosidases from a Soil Metagenome for Production of Fucosylated Human Milk Oligosaccharides.	Lezyk M, Jers C, Kjaerulff L, Gotfredsen CH, Mikkelsen MD, Mikkelsen JD.	PLoS One	10.1371/journal.pone.0147438	2016
Metabolism	Fucosylated Human Milk Oligosaccharide Foraging within the Species Bifidobacterium pseudocatenulatum Is Driven by Glycosyl Hydrolase Content and Specificity.	Shani G, Hoeflinger JL, Heiss BE, Masarweh CF, Larke JA, Jensen NM, Wickramasinghe S, Davis JC, Goonatilleke E, El-Hawiet A, Nguyen L, Klassen JS, Slupsky CM, Lebrilla CB, Mills DA.	Appl Environ Microbiol	10.1128/aem.01707-21	2022
Metabolism	In Vitro Fermentation of caprine milk oligosaccharides by bifidobacteria isolated from breast-fed infants.	Thum C, Roy NC, McNabb WC, Otter DE, Cookson AL.	Gut Microbes	10.1080/19490976.2015.1105425	2015
	Characterization of GH2 and GH42 beta-galactosidases derived from bifidobacterial infant isolates.	Ambrogi V, Bottacini F, O'Sullivan J, O'Connell Motherway M, Linqiu C, Schoemaker B, Schoterman M, van Sinderen D.	AMB Express	10.1186/s13568-019-0735-3	2019
Metabolism	A versatile and scalable strategy for glycoprofiling bifidobacterial consumption of human milk oligosaccharides.	Locascio RG, Ninonuevo MR, Kronewitter SR, Freeman SL, German JB, Lebrilla CB, Mills DA.	Microb Biotechnol	10.1111/j.1751-7915.2008.00072.x	2009
Genetics	Technological advances in bifidobacterial molecular genetics: application to functional genomics and medical treatments.	Fukiya S, Hirayama Y, Sakanaka M, Kano Y, Yokota A.	Biosci Microbiota Food Health	10.12938/bmfh.31.15	2012
Metabolism	Release and utilization of N-acetyl-D-glucosamine from human milk oligosaccharides by Bifidobacterium longum subsp. infantis.	Garrido D, Ruiz-Moyano S, Mills DA.	Anaerobe	10.1016/j.anaerobe.2012.04.012	2012
Biotechnology	Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases.	Li A, Benkoulouche M, Ladeveze S, Durand J, Cioci G, Laville E, Potocki-Veronese G.	Int J Mol Sci	10.3390/ijms23063043	2022
Genetics	VirFinder: a novel k-mer based tool for identifying viral sequences from assembled metagenomic data.	Ren J, Ahlgren NA, Lu YY, Fuhrman JA, Sun F.	Microbiome	10.1186/s40168-017-0283-5	2017
	Hydrolysis of oligosaccharides in the gastrointestinal tract alters their prebiotic effects on probiotic strains.	Lee WM, Song YB, Han KS, Sim WS, Lee BH.	Food Sci Biotechnol	10.1007/s10068-023-01474-z	2024
Genetics	Development of Real-Time PCR Assay to Specifically Detect 22 Bifidobacterium Species and Subspecies Using Comparative Genomics.	Kim HB, Kim E, Yang SM, Lee S, Kim MJ, Kim HY.	Front Microbiol	10.3389/fmicb.2020.02087	2020
	Comparison of Real-Time PCR and Droplet Digital PCR for the Quantitative Detection of Lactiplantibacillus plantarum subsp. plantarum	Choi CH, Kim E, Yang SM, Kim DS, Suh SM, Lee GY, Kim HY.	Foods	10.3390/foods11091331	2022
Metabolism	Safety Evaluations of Bifidobacterium bifidum BGN4 and Bifidobacterium longum BORI.	Kim MJ, Ku S, Kim SY, Lee HH, Jin H, Kang S, Li R, Johnston TV, Park MS, Ji GE.	Int J Mol Sci	10.3390/ijms19051422	2018
Genetics	Differentiation of Lacticaseibacillus zeae Using Pan-Genome Analysis and Real-Time PCR Method Targeting a Unique Gene.	Kim E, Yang SM, Kim HY.	Foods	10.3390/foods10092112	2021
	Assessing probiotic viability in mixed species yogurt using a novel propidium monoazide (PMAxx)-quantitative PCR method.	Marole TA, Sibanda T, Buys EM.	Front Microbiol	10.3389/fmicb.2024.1325268	2024
	Designing primers and evaluation of the efficiency of propidium monoazide - Quantitative polymerase chain reaction for counting the viable cells of Lactobacillus gasseri and Lactobacillus salivarius.	Lai CH, Wu SR, Pang JC, Ramireddy L, Chiang YC, Lin CK, Tsen HY.	J Food Drug Anal	10.1016/j.jfda.2016.10.004	2017
	Evaluation of Microencapsulated Synbiotic Preparations Containing Lactobionic Acid.	Goderska K, Kozlowski P	Appl Biochem Biotechnol	10.1007/s12010-021-03622-9	2021
Metabolism	Influence of fucosidase-producing bifidobacteria on the HBGA antigenicity of oyster digestive tissue and the associated norovirus binding.	Eshaghi Gorji M, Tan MTH, Li D	Int J Food Microbiol	10.1016/j.ijfoodmicro.2021.109058	2021
Pathogenicity	Bifidobacterium bifidum Suppresses Gut Inflammation Caused by Repeated Antibiotic Disturbance Without Recovering Gut Microbiome Diversity in Mice.	Ojima MN, Gotoh A, Takada H, Odamaki T, Xiao JZ, Katoh T, Katayama T	Front Microbiol	10.3389/fmicb.2020.01349	2020
Enzymology	Converting a beta-N-acetylhexosaminidase into two trans-beta-N-acetylhexosaminidases by domain-targeted mutagenesis.	Chen X, Jin L, Jiang X, Guo L, Gu G, Xu L, Lu L, Wang F, Xiao M	Appl Microbiol Biotechnol	10.1007/s00253-019-10253-y	2019
Enzymology	Enzymatic Synthesis of 6'-Sialyllactose, a Dominant Sialylated Human Milk Oligosaccharide, by a Novel exo-alpha-Sialidase from Bacteroides fragilis NCTC9343.	Guo L, Chen X, Xu L, Xiao M, Lu L	Appl Environ Microbiol	10.1128/AEM.00071-18	2018
Metabolism	Application study of 1,2-alpha-l-fucosynthase: introduction of Fucalpha1-2Gal disaccharide structures on N-glycan, ganglioside, and xyloglucan oligosaccharide.	Sugiyama Y, Katoh T, Honda Y, Gotoh A, Ashida H, Kurihara S, Yamamoto K, Katayama T	Biosci Biotechnol Biochem	10.1080/09168451.2016.1254532	2016
Enzymology	Efficient and Regioselective Synthesis of beta-GalNAc/GlcNAc-Lactose by a Bifunctional Transglycosylating beta-N-Acetylhexosaminidase from Bifidobacterium bifidum.	Chen X, Xu L, Jin L, Sun B, Gu G, Lu L, Xiao M	Appl Environ Microbiol	10.1128/AEM.01325-16	2016
Metabolism	alpha-N-Acetylglucosaminidase from Bifidobacterium bifidum specifically hydrolyzes alpha-linked N-acetylglucosamine at nonreducing terminus of O-glycan on gastric mucin.	Shimada Y, Watanabe Y, Wakinaka T, Funeno Y, Kubota M, Chaiwangsri T, Kurihara S, Yamamoto K, Katayama T, Ashida H	Appl Microbiol Biotechnol	10.1007/s00253-014-6201-x	2014
Metabolism	Crystal structures of a glycoside hydrolase family 20 lacto-N-biosidase from Bifidobacterium bifidum.	Ito T, Katayama T, Hattie M, Sakurama H, Wada J, Suzuki R, Ashida H, Wakagi T, Yamamoto K, Stubbs KA, Fushinobu S	J Biol Chem	10.1074/jbc.M112.420109	2013
Enzymology	Hypolipidemic effects of lactic acid bacteria fermented cereal in rats.	Banjoko IO, Adeyanju MM, Ademuyiwa O, Adebawo OO, Olalere RA, Kolawole MO, Adegbola IA, Adesanmi TA, Oladunjoye TO, Ogunnowo AA, Shorinola AA, Daropale O, Babatope EB, Osibogun AO, Ogunfowokan DT, Jentegbe TA, Apelehin TG, Ogunnowo O, Olokodana O, Fetuga FY, Omitola M, Okafor LA, Ebohon CL, Ita JO, Disu KA, Ogherebe O, Eriobu SU, Bakare AA	Lipids Health Dis	10.1186/1476-511X-11-170	2012
Enzymology	Bifidobacterial alpha-galactosidase with unique carbohydrate-binding module specifically acts on blood group B antigen.	Wakinaka T, Kiyohara M, Kurihara S, Hirata A, Chaiwangsri T, Ohnuma T, Fukamizo T, Katayama T, Ashida H, Yamamoto K	Glycobiology	10.1093/glycob/cws142	2012
Enzymology	alpha-N-acetylgalactosaminidase from infant-associated bifidobacteria belonging to novel glycoside hydrolase family 129 is implicated in alternative mucin degradation pathway.	Kiyohara M, Nakatomi T, Kurihara S, Fushinobu S, Suzuki H, Tanaka T, Shoda SI, Kitaoka M, Katayama T, Yamamoto K, Ashida H	J Biol Chem	10.1074/jbc.M111.277384	2011
Metabolism	Physiology of consumption of human milk oligosaccharides by infant gut-associated bifidobacteria.	Asakuma S, Hatakeyama E, Urashima T, Yoshida E, Katayama T, Yamamoto K, Kumagai H, Ashida H, Hirose J, Kitaoka M	J Biol Chem	10.1074/jbc.M111.248138	2011
Metabolism	An exo-alpha-sialidase from bifidobacteria involved in the degradation of sialyloligosaccharides in human milk and intestinal glycoconjugates.	Kiyohara M, Tanigawa K, Chaiwangsri T, Katayama T, Ashida H, Yamamoto K	Glycobiology	10.1093/glycob/cwq175	2010
Enzymology	Two distinct alpha-L-fucosidases from Bifidobacterium bifidum are essential for the utilization of fucosylated milk oligosaccharides and glycoconjugates.	Ashida H, Miyake A, Kiyohara M, Wada J, Yoshida E, Kumagai H, Katayama T, Yamamoto K	Glycobiology	10.1093/glycob/cwp082	2009
Metabolism	Effect of Bifidobacterium bifidum DSM 20082 cytoplasmic fraction on human immune cells.	Mouni F, Aissi E, Hernandez J, Gorocica P, Bouquelet S, Zenteno E, Lascurain R, Garfias Y	Immunol Invest	10.1080/08820130802608303	2009
Metabolism	Bifidobacterium bifidum lacto-N-biosidase, a critical enzyme for the degradation of human milk oligosaccharides with a type 1 structure.	Wada J, Ando T, Kiyohara M, Ashida H, Kitaoka M, Yamaguchi M, Kumagai H, Katayama T, Yamamoto K	Appl Environ Microbiol	10.1128/AEM.00149-08	2008
Metabolism	Characterisation of glutamine fructose-6-phosphate amidotransferase (EC 2.6.1.16) and N-acetylglucosamine metabolism in Bifidobacterium.	Foley S, Stolarczyk E, Mouni F, Brassart C, Vidal O, Aissi E, Bouquelet S, Krzewinski F	Arch Microbiol	10.1007/s00203-007-0307-9	2007
Enzymology	Identification of the putative proton donor residue of lacto-N-biose phosphorylase (EC 2.4.1.211).	Nishimoto M, Kitaoka M	Biosci Biotechnol Biochem	10.1271/bbb.70064	2007
Enzymology	Purification and identification of a growth-stimulating peptide for Bifidobacterium bifidum from natural rubber serum powder.	Etoh S, Asamura K, Obu A, Sonomoto K, Ishizaki A	Biosci Biotechnol Biochem	10.1271/bbb.64.2083	2000
Cultivation	Complementary effects of bifidogenic growth stimulators and ammonium sulfate in natural rubber serum powder on Bifidobacterium bifidum.	Etoh S, Sonomoto K, Ishizaki A	Biosci Biotechnol Biochem	10.1271/bbb.63.627	1999
Metabolism	Beta-1,3-galactosyl-N-acetylhexosamine phosphorylase from Bifidobacterium bifidum DSM 20082: characterization, partial purification and relation to mucin degradation.	Derensy-Dron D, Krzewinski F, Brassart C, Bouquelet S	Biotechnol Appl Biochem		1999
Metabolism	Glucose and galactose transport in Bifidobacterium bifidum DSM 20082.	Krzewinski F, Brassart C, Gavini F, Bouquelet S	Curr Microbiol	10.1007/s002849900234	1997
Metabolism	Characterization of the lactose transport system in the strain Bifidobacterium bifidum DSM 20082.	Krzewinski F, Brassart C, Gavini F, Bouquelet S	Curr Microbiol	10.1007/s002849900054	1996
Metabolism	High-affinity oxygen uptake by Bifidobacterium bifidum.	Cox RP, Marling N	Antonie Van Leeuwenhoek	10.1007/BF00572597	1992
Metabolism	The antioxidant and prebiotic properties of lactobionic acid.	Goderska K	Appl Microbiol Biotechnol	10.1007/s00253-019-09754-7	2019

References

#8509	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 20082
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#36043	; Curators of the CIP;
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#68371	Automatically annotated from API 50CH acid .
#68382	Automatically annotated from API zym .
#116807	Collection of Institut Pasteur ; Curators of the CIP; CIP 64.64
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Bifidobacterium bifidum (DSM 20082, JCM 1254, E319f (Variant a))

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