Leptospira interrogans (DSM 21525, icterohaemorrhagiae RGA, Leptospira interrogans serogroup Icterohaemorrhagiae, serovar Icterohaemorrhagiae, strain RGA)

Name: Leptospira interrogans (DSM 21525, icterohaemorrhagiae RGA, Leptospira interrogans serogroup Icterohaemorrhagiae, serovar Icterohaemorrhagiae, strain RGA)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 168824

Type strain

Strain Designation icterohaemorrhagiae RGA, Leptospira interrogans serogroup Icterohaemorrhagiae, serovar Icterohaemorrhagiae, strain RGA, RGA, LEP1220

Culture col. no. DSM 21525 icterohaemorrhagiae RGA Leptospira interrogans serogroup Icterohaemorrhagiae, serovar Icterohaemorrhagiae, strain RGA ATCC 43642 RGA 2 more

NCBI tax ID(s) 173

Special Collections DSMZ

History CIP <- 2002, D. Postic, Inst. Pasteur, Paris, <- -CDC, Atlanta, USA: strain RGA

Links

Leptospira interrogans icterohaemorrhagiae RGA is a bacterium of the family Leptospiraceae.

genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 38105

ATCC 23581,ATCC 43642,KCTC 2880,CCUG 5117,CRBIP6.1220,DSM 21525

@ref 20215

Last LPSN update 2026-05-29 08:46:28

Domain Bacteria

Phylum Spirochaetota

Class Spirochaetia

Order Leptospirales

Family Leptospiraceae

Genus Leptospira

Species Leptospira interrogans

Full scientific name Leptospira interrogans (Stimson 1907) Wenyon 1926 (Approved Lists 1980)

Synonyms (1)

"Spirochaeta interrogans"

BacDive ID	Other strains from **Leptospira interrogans** (99)	Type strain
172971	L. interrogans LEP1135, Swart, CRBIP6.1135
172972	L. interrogans LEP1136, Benjamin, CRBIP6.1136
172973	L. interrogans LEP1137, Bindjei, CRBIP6.1137
172974	L. interrogans LEP1138, Jones, CRBIP6.1138
172975	L. interrogans LEP1139, CRBIP6.1139
172976	L. interrogans LEP1140, Moores, CRBIP6.1140
172977	L. interrogans LEP1141, Vleermuis 90 C, CRBIP6.1141
172978	L. interrogans LEP1148, Naam, CRBIP6.1148
172979	L. interrogans LEP1150, Simon, CRBIP6.1150, CDC LT 11-67
172980	L. interrogans LEP 1152, Lai, CRBIP6.1152
172981	L. interrogans LEP 1153, M 20, CRBIP6.1153
172982	L. interrogans LEP 1169, Ballico, CRBIP6.1169
172983	L. interrogans LEP1170, Akiyami A, CRBIP6.1170
172984	L. interrogans LEP1171, Hond Utrecht IV, CRBIP6.1171
172985	L. interrogans LEP1174, Hebdomadis, CRBIP6.1174
172986	L. interrogans LEP 1179, Pomona, CRBIP6.1179
172987	L. interrogans LEP1180, Salinem, CRBIP6.1180
172988	L. interrogans LEP1183, Geyaweera, CRBIP6.1183
172989	L. interrogans LEP1184, Bangkinang I, CRBIP6.1184
172990	L. interrogans LEP1185, Rachmat, CRBIP6.1185
172991	L. interrogans LEP1186, Fudge, CRBIP6.1186
172992	L. interrogans LEP 1187, Jalna, CRBIP6.1187
172993	L. interrogans LEP1188, 3705, CRBIP6.1188
172994	L. interrogans LEP1189, Mus 24, CRBIP6.1189
172995	L. interrogans LEP1191, Hardjoprajitno, CRBIP6.1191
172996	L. interrogans LEP1193, LM 294, CRBIP6.1193
172997	L. interrogans LEP1194, Jez Bratislava, CRBIP6.1194
172998	L. interrogans LEP1197, Birkin, CRBIP6.1197
172999	L. interrogans LEP1198, Smith, CRBIP6.1198
173000	L. interrogans LEP 1200, Pomona 64, CRBIP6.1200
173001	L. interrogans LEP 1201, Lai, CRBIP6.1201
173002	L. interrogans LEP1203, Hond Utrecht IV, CRBIP6.1203
173003	L. interrogans LEP1204, Ictero 1, CRBIP6.1204
173004	L. interrogans LEP1205, Korea, CRBIP6.1205
173005	L. interrogans LEP1207, Jez Bratislava, CRBIP6.1207
173006	L. interrogans LEP1210, Bindjei, CRBIP6.1210
173007	L. interrogans LEP 1211, Ballico, CRBIP6.1211
173008	L. interrogans LEP1213, Naam, CRBIP6.1213
173009	L. interrogans LEP1214, LM 294, CRBIP6.1214
173010	L. interrogans LEP1218, Marsh, CRBIP6.1218
173011	L. interrogans LEP1219, Richardson, CRBIP6.1219
173012	L. interrogans LEP 1224, M20, CRBIP6.1224
173013	L. interrogans LEP1227, Fudge, CRBIP6.1227
173014	L. interrogans LEP1228, 3705, CRBIP6.1228
173015	L. interrogans LEP1231, Andaman, CRBIP6.1231
173016	L. interrogans LEP1232, Sumner, CRBIP6.1232
173017	L. interrogans LEP1233, Bangkok D 92, CRBIP6.1233
173018	L. interrogans LEP1234, Mus 24, CRBIP6.1234
173019	L. interrogans LEP1235, Salinem, CRBIP6.1235
173020	L. interrogans LEP1238, LT 62-68, CRBIP6.1238
173021	L. interrogans LEP1239, 1, CRBIP6.1239
173022	L. interrogans LEP1240, Ictero No 1, CRBIP6.1240
173023	L. interrogans LEP1244, CRBIP6.1244
173024	L. interrogans LEP1245, MY 1039, CRBIP6.1245
173025	L. interrogans LEP1260, Sentot, CRBIP6.1260
173026	L. interrogans LEP 1263, 7957, CRBIP6.1263
173027	L. interrogans LEP1267, Paidjan, CRBIP6.1267
173028	L. interrogans LEP1270, Salinem, CRBIP6.1270
173029	L. interrogans LEP1272, C 3, CRBIP6.1272
173030	L. interrogans LEP1278, R 740, CRBIP6.1278
173031	L. interrogans LEP1292, 136/2/2, CRBIP6.1292
173032	L. interrogans LEP1295, LT 62-68, CRBIP6.1295
173033	L. interrogans LEP 1302, Robinson, CRBIP6.1302
173034	L. interrogans LEP1304, Djasiman, CRBIP6.1304
173035	L. interrogans LEP1315, Lora, CRBIP6.1315
173036	L. interrogans LEP1317, RZ11, CRBIP6.1317
173037	L. interrogans LEP1318, 267-1348, CRBIP6.1318
173038	L. interrogans LEP1319, 267-1348, CRBIP6.1319
173039	L. interrogans LEP1326, Gurung, CRBIP6.1326
173040	L. interrogans LEP1327, München C 90, CRBIP6.1327
173041	L. interrogans LEP 1334, Szwajizak, CRBIP6.1334
173042	L. interrogans LEP1337, 267-1348, CRBIP6.1337
173043	L. interrogans LEP1351, Smith, CRBIP6.1351
173044	L. interrogans LEP 1355, A 81, CRBIP6.1355
173045	L. interrogans LEP1356, 380, CRBIP6.1356
173046	L. interrogans LEP 1359, Chiffon, CRBIP6.1359
173047	L. interrogans LEP1361, 164, CRBIP6.1361
173048	L. interrogans LEP1372, Wijnberg, CRBIP6.1372
173049	L. interrogans LEP 1375, Kremastos, CRBIP6.1375
173050	L. interrogans LEP 1397, Szwajizak, CRBIP6.1397
173051	L. interrogans LEP1398, Biggs, CRBIP6.1398
173052	L. interrogans LEP 1401, H2, CRBIP6.1401
173053	L. interrogans LEP1409, Wijinberg, CRBIP6.1409
173054	L. interrogans LEP 1414, Zanoni, CRBIP6.1414
173055	L. interrogans LEP1415, Abraham, CRBIP6.1415
173056	L. interrogans LEP 1417, Robinson, CRBIP6.1417
173057	L. interrogans LEP 1420, Szwajizak, CRBIP6.1420
173058	L. interrogans LEP1425, Biggs, CRBIP6.1425
173059	L. interrogans LEP1426, LT 398, CRBIP6.1426
173060	L. interrogans LEP 1427, Valbuzzi, CRBIP6.1427
173061	L. interrogans LEP1429, LT 64-67, CRBIP6.1429
173062	L. interrogans LEP1432, LT 65-68, CRBIP6.1432
173063	L. interrogans LEP1442, R 740, CRBIP6.1442
173064	L. interrogans LEP1459, LT 1026, CRBIP6.1459
173065	L. interrogans LEP1471, yamamoto, CRBIP6.1471
173066	L. interrogans LEP1475, Gurung, CRBIP6.1475
173067	L. interrogans LEP1481, Andaman, CRBIP6.1481
173068	L. interrogans LEP 1485, HK6, CRBIP6.1485
173069	L. interrogans LEP1487, LT 63-68, CRBIP6.1487

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	99.395
125438	negative	93.829

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link
120197	CIP Medium 189		Medium recipe at CIP

Culture temp

@ref	Growth	Type	Temperature (°C)
120197	positive	growth	29

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
125439	facultative anaerobe	94.62

Spore formation

@ref	Spore formation	Confidence
125439		98.862

Metabolite utilization

@ref	Chebi-ID	Metabolite	Utilization activity	Kind of utilization tested
68371	27613 ChEBI	amygdalin	-	builds acid from	from API 50CH acid
68371	18305 ChEBI	arbutin	-	builds acid from	from API 50CH acid
68371	17057 ChEBI	cellobiose	-	builds acid from	from API 50CH acid
68371	17108 ChEBI	D-arabinose	-	builds acid from	from API 50CH acid
68371	18333 ChEBI	D-arabitol	-	builds acid from	from API 50CH acid
68371	15824 ChEBI	D-fructose	-	builds acid from	from API 50CH acid
68371	28847 ChEBI	D-fucose	-	builds acid from	from API 50CH acid
68371	12936 ChEBI	D-galactose	-	builds acid from	from API 50CH acid
68371	17634 ChEBI	D-glucose	-	builds acid from	from API 50CH acid
68371	62318 ChEBI	D-lyxose	-	builds acid from	from API 50CH acid
68371	16899 ChEBI	D-mannitol	-	builds acid from	from API 50CH acid
68371	16024 ChEBI	D-mannose	-	builds acid from	from API 50CH acid
68371	16988 ChEBI	D-ribose	-	builds acid from	from API 50CH acid
68371	17924 ChEBI	D-sorbitol	-	builds acid from	from API 50CH acid
68371	16443 ChEBI	D-tagatose	-	builds acid from	from API 50CH acid
68371	65327 ChEBI	D-xylose	-	builds acid from	from API 50CH acid
68371	17113 ChEBI	erythritol	-	builds acid from	from API 50CH acid
68371	4853 ChEBI	esculin	-	builds acid from	from API 50CH acid
68371	16813 ChEBI	galactitol	-	builds acid from	from API 50CH acid
68371	28066 ChEBI	gentiobiose	-	builds acid from	from API 50CH acid
68371	24265 ChEBI	gluconate	-	builds acid from	from API 50CH acid
68371	17754 ChEBI	glycerol	-	builds acid from	from API 50CH acid
68371	28087 ChEBI	glycogen	-	builds acid from	from API 50CH acid
68371	15443 ChEBI	inulin	-	builds acid from	from API 50CH acid
68371	30849 ChEBI	L-arabinose	-	builds acid from	from API 50CH acid
68371	18403 ChEBI	L-arabitol	-	builds acid from	from API 50CH acid
68371	18287 ChEBI	L-fucose	-	builds acid from	from API 50CH acid
68371	62345 ChEBI	L-rhamnose	-	builds acid from	from API 50CH acid
68371	17266 ChEBI	L-sorbose	-	builds acid from	from API 50CH acid
68371	65328 ChEBI	L-xylose	-	builds acid from	from API 50CH acid
68371	17716 ChEBI	lactose	-	builds acid from	from API 50CH acid
68371	17306 ChEBI	maltose	-	builds acid from	from API 50CH acid
68371	6731 ChEBI	melezitose	-	builds acid from	from API 50CH acid
68371	28053 ChEBI	melibiose	-	builds acid from	from API 50CH acid
68371	320061 ChEBI	methyl alpha-D-glucopyranoside	-	builds acid from	from API 50CH acid
68371	43943 ChEBI	methyl alpha-D-mannoside	-	builds acid from	from API 50CH acid
68371	74863 ChEBI	methyl beta-D-xylopyranoside	-	builds acid from	from API 50CH acid
68371	17268 ChEBI	myo-inositol	-	builds acid from	from API 50CH acid
68371	59640 ChEBI	N-acetylglucosamine	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 2-ketogluconate	-	builds acid from	from API 50CH acid
68371	0 ChEBI	Potassium 5-ketogluconate	-	builds acid from	from API 50CH acid
68371	16634 ChEBI	raffinose	-	builds acid from	from API 50CH acid
68371	15963 ChEBI	ribitol	-	builds acid from	from API 50CH acid
68371	17814 ChEBI	salicin	-	builds acid from	from API 50CH acid
68371	28017 ChEBI	starch	-	builds acid from	from API 50CH acid
68371	17992 ChEBI	sucrose	-	builds acid from	from API 50CH acid
68371	27082 ChEBI	trehalose	-	builds acid from	from API 50CH acid
68371	32528 ChEBI	turanose	-	builds acid from	from API 50CH acid
68371	17151 ChEBI	xylitol	-	builds acid from	from API 50CH acid

API 50CHac

@ref	ControlQ	GLY	ERY	DARA	LARA	RIB	DXYL	LXYL	ADO	MDX	GAL	GLU	FRU	MNE	SBE	RHA	DUL	INO	MAN	SOR	MDM	MDG	NAG	AMY	ARB	ESC	SAL	CEL	MAL	LAC	MEL	SAC	TRE	INU	MLZ	RAF	AMD	GLYG	XLT	GEN	TUR	LYX	TAG	DFUC	LFUC	DARL	LARL	GNT	2KG	5KG
120197	not determinedn.d.	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-

Isolation, sampling and environmental information

Taxonmaps

69479

Global distribution of 16S sequence Z12817 (>99% sequence identity) for Leptospira from Microbeatlas

Aquatic Samples	210
Soil Samples	127
Animal Samples	210
Plant Samples	25
Total Samples	572

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
20215	2	Risk group
120197	2	Risk group (French classification)

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	IMG-taxon 2681812812 annotated assembly for Leptospira interrogans ATCC 43642	scaffold	GCA_900156205	173.142	2681812812	173	53.38
66792	CA_glsol113 assembly for Leptospira interrogans serovar Icterohaemorrhagiae str. RGA	contig	GCA_000343165	1291351.3	2551306603	1291351	39.46

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20215	L.interrogans 16S ribosomal RNA	Z12817	1396		173

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: IMG-taxon 2681812812 annotated assembly for Leptospira interrogans ATCC 43642
BV-BRC: 173.142

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	no	98.86	no
125439	motility	BacteriaNetⓘ	no	66.45	no
125439	gram_stain	BacteriaNetⓘ	negative	99.40	no
125439	oxygen_tolerance	BacteriaNetⓘ	facultative anaerobe	94.62	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Leptospira interrogans ATCC 43642
NCBI: GCA_900156205.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	93.83	no
125438	anaerobic	anaerobicⓘ	no	82.94	no
125438	aerobic	aerobicⓘ	yes	64.52	no
125438	spore-forming	spore-formingⓘ	no	80.98	no
125438	thermophilic	thermophileⓘ	no	85.26	yes
125438	flagellated	motile2+ⓘ	yes	52.13	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	Ketone body oxidation and susceptibility to ethyl acetoacetate in a novel hemolytic multidrug-resistant strain Leptospira interrogans KeTo originated from sewage water.	Sonam A, Hameed A, Rekha PD, Stothard P, Tellis RC, Arun AB.	Sci Rep	10.1038/s41598-024-76546-z	2024
Genetics	Complete Genome Sequencing of Leptospira interrogans Isolates from Malaysia Reveals Massive Genome Rearrangement but High Conservation of Virulence-Associated Genes.	Ramli SR, Bunk B, Sproer C, Geffers R, Jarek M, Bhuju S, Goris M, Mustakim S, Pessler F.	Pathogens	10.3390/pathogens10091198	2021
	Diagnostic efficacy of lsa63 antigen for human leptospirosis.	Alizadeh SA, Eshraghi SS, Pourmand MR, Naserpour T, Abdollahpour G, Rahimiforoshani A, Najafipour R.	Iran Red Crescent Med J	10.5812/ircmj.14753	2014
	New approach for serological testing for leptospirosis by using detection of leptospira agglutination by flow cytometry light scatter analysis.	Yitzhaki S, Barnea A, Keysary A, Zahavy E.	J Clin Microbiol	10.1128/jcm.42.4.1680-1685.2004	2004
Pathogenicity	Broth microdilution susceptibility testing for Leptospira spp.	Murray CK, Hospenthal DR.	Antimicrob Agents Chemother	10.1128/aac.48.5.1548-1552.2004	2004
	The changing epidemiology of leptospirosis in Israel.	Kariv R, Klempfner R, Barnea A, Sidi Y, Schwartz E.	Emerg Infect Dis	10.3201/eid0706.010611	2001
	Polymerase chain reaction primers and probes derived from flagellin gene sequences for specific detection of the agents of Lyme disease and North American relapsing fever.	Picken RN.	J Clin Microbiol	10.1128/jcm.30.1.99-114.1992	1992
Phylogeny	Characterization of Leptospiraceae by 16S DNA restriction fragment length polymorphisms.	Hookey JV	J Gen Microbiol	10.1099/00221287-139-8-1681	1993
Phylogeny	ATCC 43642 replaces ATCC 23581 as the type strain of Leptospira interrogans (Stimson 1907) Wenyon 1926. Opinion 91. Judicial Commission of the International Committee on Systematics of Prokaryotes.	Tindall BJ	Int J Syst Evol Microbiol	10.1099/ijs.0.069179-0	2014
Phylogeny	Proposal to list ATCC 43642 as the type strain of Leptospira interrogans in the Approved Lists of Bacterial Names. Request for an opinion.	Landon S, Tang J	Int J Syst Evol Microbiol	10.1099/ijs.0.63106-0	2004
Stress	Effect of heat or formalin treatment of leptospires on antibody response detected by immunoblotting.	Pope V, Johnson RC	J Clin Microbiol	10.1128/jcm.29.7.1548-1550.1991	1991
Phylogeny	A comparative investigation and identification of Leptospira interrogans serogroup icterohaemorrhagiae strains by monoclonal antibody and DNA fingerprint analyses.	Hookey JV, Palmer MF	Zentralbl Bakteriol	10.1016/s0934-8840(11)80065-4	1991
Phylogeny	The detection of genetic variation in Leptospira interrogans serogroup ICTEROHAEMORRHAGIAE by ribosomal RNA gene restriction fragment patterns.	Hookey JV	FEMS Microbiol Lett	10.1016/0378-1097(90)90326-l	1990
Enzymology	Restriction endonuclease DNA analysis of Leptospira interrogans serovars icterohaemorrhagiae and hebdomadis.	Marshall RB, Winter PJ, Yanagawa R	J Clin Microbiol	10.1128/jcm.20.4.808-810.1984	1984
Phylogeny	Characterization of monoclonal antibodies against etiological agents of Weil's disease.	Kobayashi Y, Tamai T, Oyama T, Hasegawa H, Sada E, Kusaba T, Hamaji M	Microbiol Immunol	10.1111/j.1348-0421.1984.tb00687.x	1984

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#68371	Automatically annotated from API 50CH acid .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#120197	Collection of Institut Pasteur ; Curators of the CIP; CRBIP6.1220
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Leptospira interrogans (DSM 21525, icterohaemorrhagiae RGA, Leptospira interrogans serogroup Icterohaemorrhagiae, serovar Icterohaemorrhagiae, strain RGA)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Culture medium

Culture temp

Physiology and metabolism

Oxygen tolerance

Spore formation

Metabolite utilization

API 50CHac

Isolation, sampling and environmental information

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_900156205

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

BacDive

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