Pyrococcus furiosus (DSM 3638, ATCC 43587, JCM 8422)

Name: Pyrococcus furiosus (DSM 3638, ATCC 43587, JCM 8422)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 16854

Type strain

Strain Designation Vc 1

Culture col. no. DSM 3638 ATCC 43587 JCM 8422 Vc 1 CGMCC 1.2516

NCBI tax ID(s) 186497 2261

Special Collections DSMZ JCM

History <- K.O. Stetter and G. Fiala, Vc 1 DSM 3638 <-- K. O. Stetter and G. Fiala Vc 1.

Links

Pyrococcus furiosus Vc 1 is an anaerobe, hyperthermophilic prokaryote that was isolated from geothermally heated marine sediment.

anaerobe hyperthermophilic genome sequence 16S sequence

Name and taxonomic classification

SI-ID 45148

ATCC 43587,DSM 3638,JCM 8422,CGMCC 1.2516

@ref 20215

Last LPSN update 2026-02-09 11:22:04

Domain Archaea

Phylum Methanobacteriota

Class Thermococci

Order Thermococcales

Family Thermococcaceae

Genus Pyrococcus

Species Pyrococcus furiosus

Full scientific name Pyrococcus furiosus Fiala and Stetter 1986

BacDive ID	Other strains from **Pyrococcus furiosus** (1)	Type strain
16855	P. furiosus P3, DSM 12594

Morphology

Culture and growth conditions

Culture medium

@ref	Name	Growth	Medium link	Composition
1428	PYROCOCCUS MEDIUM (DSMZ Medium 377)		Medium recipe at MediaDive	Name: PYROCOCCUS MEDIUM (DSMZ Medium 377) Composition: Sulfur 30.0 g/l Peptone 5.0 g/l MgCl2 x 6 H2O 2.75 g/l Yeast extract 1.0 g/l KH2PO4 0.5 g/l Na2S x 9 H2O 0.5 g/l KCl 0.33 g/l NaBr 0.05 g/l MgSO4 x 7 H2O 0.03 g/l Nitrilotriacetic acid 0.015 g/l NaCl 0.01 g/l (NH4)2SO4 0.01 g/l SrCl2 x 6 H2O 0.007 g/l Citric acid 0.005 g/l MnSO4 x H2O 0.005 g/l CoSO4 x 7 H2O 0.0018 g/l ZnSO4 x 7 H2O 0.0018 g/l CaCl2 x 2 H2O 0.001 g/l FeSO4 x 7 H2O 0.001 g/l Sodium resazurin 0.0005 g/l NiCl2 x 6 H2O 0.0003 g/l AlK(SO4)2 x 12 H2O 0.0002 g/l CuSO4 x 5 H2O 0.0001 g/l Na2MoO4 x 2 H2O 0.0001 g/l H3BO3 0.0001 g/l KI 5e-05 g/l Na2WO4 x 2 H2O 4e-06 g/l Na2SeO3 x 5 H2O 3e-06 g/l Distilled water

Culture temp

@ref	Growth	Type	Temperature (°C)	Range
1428	positive	growth	97	hyperthermophilic
67770	positive	growth	95	hyperthermophilic

Physiology and metabolism

Oxygen tolerance

@ref	Oxygen tolerance	Confidence
1428	anaerobe
125439	anaerobe	99.8

Compound production

1428

CompoundDNA polymerase Pfu

Pathway annotation

Computationally determined by

@ref	pathway	enzyme coverage	annotated reactions
66794	UDP-GlcNAc biosynthesis	100	3 of 3
66794	glycolate and glyoxylate degradation	100	6 of 6
66794	mannosylglycerate biosynthesis	100	2 of 2
66794	coenzyme A metabolism	100	4 of 4
66794	L-lactaldehyde degradation	100	3 of 3
66794	ribulose monophosphate pathway	100	2 of 2
66794	vitamin B1 metabolism	92.31	12 of 13
66794	chorismate metabolism	88.89	8 of 9
66794	valine metabolism	88.89	8 of 9
66794	aspartate and asparagine metabolism	88.89	8 of 9
66794	photosynthesis	85.71	12 of 14
66794	glycolysis	82.35	14 of 17
66794	hydrogen production	80	4 of 5
66794	molybdenum cofactor biosynthesis	77.78	7 of 9
66794	NAD metabolism	77.78	14 of 18
66794	palmitate biosynthesis	77.27	17 of 22
66794	acetate fermentation	75	3 of 4
66794	biotin biosynthesis	75	3 of 4
66794	6-hydroxymethyl-dihydropterin diphosphate biosynthesis	75	6 of 8
66794	glycogen biosynthesis	75	3 of 4
66794	CMP-KDO biosynthesis	75	3 of 4
66794	C4 and CAM-carbon fixation	75	6 of 8
66794	isoleucine metabolism	75	6 of 8
66794	gluconeogenesis	75	6 of 8
66794	flavin biosynthesis	73.33	11 of 15
66794	pentose phosphate pathway	72.73	8 of 11
66794	myo-inositol biosynthesis	70	7 of 10
66794	starch degradation	70	7 of 10
66794	threonine metabolism	70	7 of 10
66794	urea cycle	69.23	9 of 13
66794	pantothenate biosynthesis	66.67	4 of 6
66794	acetoin degradation	66.67	2 of 3
66794	pyrimidine metabolism	66.67	30 of 45
66794	formaldehyde oxidation	66.67	2 of 3
66794	d-mannose degradation	66.67	6 of 9
66794	serine metabolism	66.67	6 of 9
66794	alanine metabolism	65.52	19 of 29
66794	glutamate and glutamine metabolism	64.29	18 of 28
66794	methionine metabolism	61.54	16 of 26
66794	phenylalanine metabolism	61.54	8 of 13
66794	propionate fermentation	60	6 of 10
66794	lipoate biosynthesis	60	3 of 5
66794	methylglyoxal degradation	60	3 of 5
66794	Entner Doudoroff pathway	60	6 of 10
66794	purine metabolism	59.57	56 of 94
66794	tyrosine metabolism	57.14	8 of 14
66794	propanol degradation	57.14	4 of 7
66794	reductive acetyl coenzyme A pathway	57.14	4 of 7
66794	polyamine pathway	56.52	13 of 23
66794	cysteine metabolism	55.56	10 of 18
66794	arginine metabolism	54.17	13 of 24
66794	leucine metabolism	53.85	7 of 13
66794	tryptophan metabolism	52.63	20 of 38
66794	suberin monomers biosynthesis	50	1 of 2
66794	dolichol and dolichyl phosphate biosynthesis	50	1 of 2
66794	ethanol fermentation	50	1 of 2
66794	CDP-diacylglycerol biosynthesis	50	1 of 2
66794	citric acid cycle	50	7 of 14
66794	sulfopterin metabolism	50	2 of 4
66794	glycine metabolism	50	5 of 10
66794	cis-vaccenate biosynthesis	50	1 of 2
66794	selenocysteine biosynthesis	50	3 of 6
66794	degradation of aromatic, nitrogen containing compounds	50	6 of 12
66794	ketogluconate metabolism	50	4 of 8
66794	aminopropanol phosphate biosynthesis	50	1 of 2
66794	oxidative phosphorylation	48.35	44 of 91
66794	histidine metabolism	48.28	14 of 29
66794	lysine metabolism	47.62	20 of 42
66794	sulfate reduction	46.15	6 of 13
66794	lipid metabolism	45.16	14 of 31
66794	CO2 fixation in Crenarchaeota	44.44	4 of 9
66794	tetrahydrofolate metabolism	42.86	6 of 14
66794	factor 420 biosynthesis	40	2 of 5
66794	cellulose degradation	40	2 of 5
66794	metabolism of amino sugars and derivatives	40	2 of 5
66794	glycogen metabolism	40	2 of 5
66794	degradation of hexoses	38.89	7 of 18
66794	dolichyl-diphosphooligosaccharide biosynthesis	36.36	4 of 11
66794	metabolism of disaccharids	36.36	4 of 11
66794	glutathione metabolism	35.71	5 of 14
66794	isoprenoid biosynthesis	34.62	9 of 26
66794	non-pathway related	34.21	13 of 38
66794	cyanate degradation	33.33	1 of 3
66794	lipid A biosynthesis	33.33	3 of 9
66794	acetyl CoA biosynthesis	33.33	1 of 3
66794	octane oxidation	33.33	1 of 3
66794	nitrate assimilation	33.33	3 of 9
66794	IAA biosynthesis	33.33	1 of 3
66794	vitamin B12 metabolism	32.35	11 of 34
66794	degradation of pentoses	32.14	9 of 28
66794	ubiquinone biosynthesis	28.57	2 of 7
66794	mevalonate metabolism	28.57	2 of 7
66794	d-xylose degradation	27.27	3 of 11
66794	ascorbate metabolism	27.27	6 of 22
66794	vitamin B6 metabolism	27.27	3 of 11
66794	peptidoglycan biosynthesis	26.67	4 of 15
66794	alginate biosynthesis	25	1 of 4
66794	phenol degradation	25	5 of 20
66794	lactate fermentation	25	1 of 4
66794	cyclohexanol degradation	25	1 of 4
66794	toluene degradation	25	1 of 4
66794	butanoate fermentation	25	1 of 4
66794	methanogenesis from CO2	25	3 of 12
66794	dTDPLrhamnose biosynthesis	25	2 of 8
66794	catecholamine biosynthesis	25	1 of 4
66794	phosphatidylethanolamine bioynthesis	23.08	3 of 13

Isolation, sampling and environmental information

Isolation source categories

Cat1	Cat2	Cat3
#Environmental	#Aquatic	#Marine
#Environmental	#Aquatic	#Sediment

Isolation

@ref	Sample type	Geographic location	Country	Country ISO 3 Code	Continent
1428	geothermally heated marine sediment	Vulcano island	Italy	ITA	Europe
67770	Hot sediment at the beach of Porto di Levante	Vulcano Island	Italy	ITA	Europe

Interaction and safety

Risk assessment

@ref	Biosafety level	Biosafety level comment
1428	1	Risk group (German classification) According to TRBA 466

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM730v1 assembly for Pyrococcus furiosus DSM 3638	complete	GCA_000007305	186497.12	638154515	186497	98.29
66792	ASM824508v1 assembly for Pyrococcus furiosus DSM 3638	complete	GCA_008245085	186497.32	8001923808	186497	97.62

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20218	Pyrococcus furiosus gene for 16S rRNA, partial sequence, strain: JCM 8422	AB603518	1321		2261
20218	Pyrococcus furiosus 16S ribosomal RNA gene, partial sequence; 16S-23S intergenic ribosomal RNA spacer, complete sequence; tRNA-Ala gene, complete sequence; and 23S ribosomal RNA gene, partial sequence	L36458	471		2261

GC content

@ref	GC-content (mol%)	Method
1428	38.0
67770	38.3	thermal denaturation, midpoint method (Tm)
67770	37.1	high performance liquid chromatography (HPLC)

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Pyrococcus furiosus DSM 3638
NCBI: GCA_008245085

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	spore_formation	BacteriaNetⓘ	yes	77.00	no
125439	motility	BacteriaNetⓘ	yes	67.20	no
125439	gram_stain	BacteriaNetⓘ	variable	86.50	no
125439	oxygen_tolerance	BacteriaNetⓘ	anaerobe	99.80	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Pyrococcus furiosus DSM 3638 DSM 3638
NCBI: GCA_008245085.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	67.94	no
125438	anaerobic	anaerobicⓘ	yes	87.82	no
125438	aerobic	aerobicⓘ	no	88.42	yes
125438	spore-forming	spore-formingⓘ	no	88.01	no
125438	thermophilic	thermophileⓘ	yes	80.87	yes
125438	flagellated	motile2+ⓘ	no	83.08	no

Literature

Topic	Title	Authors	Journal	DOI	Year
Genetics	Engineering the hyperthermophilic archaeon Pyrococcus furiosus for 1-propanol production.	O'Quinn HC, Vailionis JL, Tanwee TNN, Holandez-Lopez KS, Bing RG, Poole FL, Zhang Y, Kelly RM, Adams MWW.	Appl Environ Microbiol	10.1128/aem.00471-25	2025
Genetics	A novel acidic laminarinase derived from Jermuk hot spring metagenome.	Paloyan A, Soghomonyan T, Karapetyan M, Grigoryan H, Kruger A, Cuskin F, Marles-Wright J, Burkhardt C, Antranikian G.	Appl Microbiol Biotechnol	10.1007/s00253-025-13557-4	2025
	The transcriptional regulator EarA and intergenic terminator sequences modulate archaellation in Pyrococcus furiosus.	Stockl R, Nissl L, Reichelt R, Rachel R, Grohmann D, Grunberger F.	Front Microbiol	10.3389/fmicb.2023.1241399	2023
Genetics	Optimizing Strategies for Bio-Based Ethanol Production Using Genome-Scale Metabolic Modeling of the Hyperthermophilic Archaeon, Pyrococcus furiosus.	Vailionis JL, Zhao W, Zhang K, Rodionov DA, Lipscomb GL, Tanwee TNN, O'Quinn HC, Bing RG, Kelly RM, Adams MWW, Zhang Y.	Appl Environ Microbiol	10.1128/aem.00563-23	2023
	Computational analysis of genes with lethal knockout phenotype and prediction of essential genes in archaea.	Makarova KS, Zhang C, Wolf YI, Karamycheva S, Whitaker RJ, Koonin EV.	mBio	10.1128/mbio.03092-23	2024
Transcriptome	Uncovering the temporal dynamics and regulatory networks of thermal stress response in a hyperthermophile using transcriptomics and proteomics.	Grunberger F, Schmid G, El Ahmad Z, Fenk M, Vogl K, Reichelt R, Hausner W, Urlaub H, Lenz C, Grohmann D.	mBio	10.1128/mbio.02174-23	2023
Enzymology	Manipulating Fermentation Pathways in the Hyperthermophilic Archaeon Pyrococcus furiosus for Ethanol Production up to 95°C Driven by Carbon Monoxide Oxidation.	Lipscomb GL, Crowley AT, Nguyen DMN, Keller MW, O'Quinn HC, Tanwee TNN, Vailionis JL, Zhang K, Zhang Y, Kelly RM, Adams MWW.	Appl Environ Microbiol	10.1128/aem.00012-23	2023
	Repurposing Type I-A CRISPR-Cas3 for a robust diagnosis of human papillomavirus (HPV).	Hu T, Ji Q, Ke X, Zhou H, Zhang S, Ma S, Yu C, Ju W, Lu M, Lin Y, Ou Y, Zhou Y, Xiao Y, Xu C, Hu C.	Commun Biol	10.1038/s42003-024-06537-3	2024
	Structural and functional analyses of Burkholderia pseudomallei BPSL1038 reveal a Cas-2/VapD nuclease sub-family.	Shaibullah S, Shuhaimi N, Ker DS, Mohd-Sharif N, Ho KL, Teh AH, Waterman J, Tang TH, Wong RR, Nathan S, Mohamed R, Ng MJ, Fung SY, Jonet MA, Firdaus-Raih M, Ng CL.	Commun Biol	10.1038/s42003-023-05265-4	2023
Enzymology	Molecular Characterization of the Iron-Containing Alcohol Dehydrogenase from the Extremely Thermophilic Bacterium Pseudothermotoga hypogea.	Hao L, Ayinla Z, Ma K.	Microorganisms	10.3390/microorganisms12020311	2024
Genetics	Unraveling nitrogen metabolism, cold and stress adaptation in polar Bosea sp. PAMC26642 through comparative genome analysis.	Khanal A, Han SR, Lee JH, Oh TJ.	Front Microbiol	10.3389/fmicb.2024.1505699	2024
	Metabolic engineering of Caldicellulosiruptor bescii for hydrogen production.	Cha M, Kim JK, Lee WH, Song H, Lee TG, Kim SK, Kim SJ.	Appl Microbiol Biotechnol	10.1007/s00253-023-12974-7	2024
	High hydrostatic pressure promotes gene transcription via a cystathionine-beta-synthase domain-containing protein in the hyperthermophilic archaeon Pyrococcus yayanosii.	Li C, Li S, Song Q, Da LT, Xu J.	Nucleic Acids Res	10.1093/nar/gkae1289	2025
	A Proposal of the Ur-RNAome.	Palacios-Perez M, Jose MV.	Genes (Basel)	10.3390/genes14122158	2023
	Insights into the Distribution and Functional Properties of l-Asparaginase in the Archaeal Domain and Characterization of Picrophilus torridus Asparaginase Belonging to the Novel Family Asp2like1.	Sharma A, Kaushik V, Goel M.	ACS Omega	10.1021/acsomega.2c01127	2022
	Database-Driven Identification of Structurally Similar Protein-Protein Interfaces.	Graef J, Ehrt C, Reim T, Rarey M.	J Chem Inf Model	10.1021/acs.jcim.3c01462	2024
Genetics	Compensatory relationship between low-complexity regions and gene paralogy in the evolution of prokaryotes.	Persi E, Wolf YI, Karamycheva S, Makarova KS, Koonin EV.	Proc Natl Acad Sci U S A	10.1073/pnas.2300154120	2023
	Early-Branching Cyanobacteria Grow Faster and Upregulate Superoxide Dismutase Activity Under a Simulated Early Earth Anoxic Atmosphere.	Tamanna SS, Boden JS, Kaiser KM, Wannicke N, Horing J, Sanchez-Baracaldo P, Deponte M, Frankenberg-Dinkel N, Gehringer MM.	Geobiology	10.1111/gbi.70005	2024
	Environment and taxonomy shape the genomic signature of prokaryotic extremophiles.	Arias PM, Butler J, Randhawa GS, Soltysiak MPM, Hill KA, Kari L.	Sci Rep	10.1038/s41598-023-42518-y	2023
Enzymology	High hydrostatic pressure enhanced the growth of deep-sea Thermococcus aciditolerans by promoting the reduction of elemental sulfur.	Jiao ZX, Li XG, Zhang WJ, Zhang GY, Bai SJ, Fu L, Wu LF.	Front Microbiol	10.3389/fmicb.2025.1643593	2025
Genetics	Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools.	Hu C, Ni D, Nam KH, Majumdar S, McLean J, Stahlberg H, Terns MP, Ke A.	Mol Cell	10.1016/j.molcel.2022.06.007	2022
Genetics	On distinguishing between canonical tRNA genes and tRNA gene fragments in prokaryotes.	van der Gulik PTS, Egas M, Kraaijeveld K, Dombrowski N, Groot AT, Spang A, Hoff WD, Gallie J.	RNA Biol	10.1080/15476286.2023.2172370	2023
Metabolism	Site-Differentiated Iron-Sulfur Cluster Ligation Affects Flavin-Based Electron Bifurcation Activity.	Wise CE, Ledinina AE, Lubner CE.	Metabolites	10.3390/metabo12090823	2022
Metabolism	A novel bifunctional aldehyde/alcohol dehydrogenase catalyzing reduction of acetyl-CoA to ethanol at temperatures up to 95 °C.	Wang Q, Sha C, Wang H, Ma K, Wiegle J, Abomohra AE, Shao W.	Sci Rep	10.1038/s41598-020-80159-7	2021
Biotechnology	A novel engineered strain of Methylorubrum extorquens for methylotrophic production of glycolic acid.	Dietz K, Sagstetter C, Speck M, Roth A, Klamt S, Fabarius JT.	Microb Cell Fact	10.1186/s12934-024-02583-y	2024
Genetics	Unraveling the Metabolic Potential of Asgardarchaeota in a Sediment from the Mediterranean Hydrocarbon-Contaminated Water Basin Mar Piccolo (Taranto, Italy).	Firrincieli A, Negroni A, Zanaroli G, Cappelletti M.	Microorganisms	10.3390/microorganisms9040859	2021
	Fine-scale metabolic discontinuity in a stratified prokaryote microbiome of a Red Sea deep halocline.	Michoud G, Ngugi DK, Barozzi A, Merlino G, Calleja ML, Delgado-Huertas A, Moran XAG, Moran XAG, Daffonchio D.	ISME J	10.1038/s41396-021-00931-z	2021
	Cmr3 regulates the suppression on cyclic oligoadenylate synthesis by tag complementarity in a Type III-B CRISPR-Cas system.	Guo T, Zheng F, Zeng Z, Yang Y, Li Q, She Q, Han W.	RNA Biol	10.1080/15476286.2019.1642725	2019
Genetics	Genome-guided isolation of the hyperthermophilic aerobe Fervidibacter sacchari reveals conserved polysaccharide metabolism in the Armatimonadota.	Nou NO, Covington JK, Lai D, Mayali X, Seymour CO, Johnston J, Jiao JY, Buessecker S, Mosier D, Muok AR, Torosian N, Cook AM, Briegel A, Woyke T, Eloe-Fadrosh E, Shapiro N, Bryan SG, Sleezer S, Dimapilis J, Gonzalez C, Gonzalez L, Noriega M, Hess M, Carlson RP, Liu L, Li MM, Lian ZH, Zhu S, Liu F, Sun X, Gao B, Mewalal R, Harmon-Smith M, Blaby IK, Cheng JF, Weber PK, Grigorean G, Li WJ, Dekas AE, Pett-Ridge J, Dodsworth JA, Palmer M, Hedlund BP.	Nat Commun	10.1038/s41467-024-53784-3	2024
	Characterization of the ATPase FlaI of the motor complex of the Pyrococcus furiosus archaellum and its interactions between the ATP-binding protein FlaH.	Chaudhury P, van der Does C, Albers SV.	PeerJ	10.7717/peerj.4984	2018
Metabolism	The TK0271 Protein Activates Transcription of Aromatic Amino Acid Biosynthesis Genes in the Hyperthermophilic Archaeon Thermococcus kodakarensis.	Yamamoto Y, Kanai T, Kaneseki T, Atomi H.	mBio	10.1128/mbio.01213-19	2019
	Comprehensive analysis of repetitive extragenic palindrome sequences identified in bacteria and archaea using a new web-based tool, RepRanger.	Murashko ON, Morgan-Lang C, Yu C-HA, Lin H-N, Chao Kaberdina A, Kung S-Y, Kaberdin VR, Lin-Chao S.	mSphere	10.1128/msphere.00124-25	2025
Enzymology	Comparative Genomics Reveal the Animal-Associated Features of the Acanthopleuribacteraceae Bacteria, and Description of Sulfidibacter corallicola gen. nov., sp., nov.	Wang G, Li Y, Liu J, Chen B, Su H, Liang J, Huang W, Yu K.	Front Microbiol	10.3389/fmicb.2022.778535	2022
Enzymology	Fusion of DNA-binding domain of Pyrococcus furiosus ligase with TaqStoffel DNA polymerase as a useful tool in PCR with difficult targets.	Spibida M, Krawczyk B, Zalewska-Piatek B, Piatek R, Wysocka M, Olszewski M.	Appl Microbiol Biotechnol	10.1007/s00253-017-8560-6	2018
Genetics	A consensus protocol for the recovery of mercury methylation genes from metagenomes.	Capo E, Peterson BD, Kim M, Jones DS, Acinas SG, Amyot M, Bertilsson S, Bjorn E, Buck M, Cosio C, Elias DA, Gilmour C, Goni-Urriza M, Gu B, Lin H, Liu YR, McMahon K, Moreau JW, Pinhassi J, Podar M, Puente-Sanchez F, Sanchez P, Storck V, Tada Y, Vigneron A, Walsh DA, Vandewalle-Capo M, Bravo AG, Gionfriddo CM.	Mol Ecol Resour	10.1111/1755-0998.13687	2023
Metabolism	Proteolytic Maturation of the Outer Membrane c-Type Cytochrome OmcZ by a Subtilisin-Like Serine Protease Is Essential for Optimal Current Production by Geobacter sulfurreducens.	Kai A, Tokuishi T, Fujikawa T, Kawano Y, Ueki T, Nagamine M, Sakakibara Y, Suiko M, Inoue K.	Appl Environ Microbiol	10.1128/aem.02617-20	2021
Metabolism	A High-Throughput Mass-Spectrometry-Based Assay for Identifying the Biochemical Functions of Putative Glycosidases.	Peng T, Nagy G, Trinidad JC, Jackson JM, Pohl NLB.	Chembiochem	10.1002/cbic.201700292	2017
	Heterologous Production of an Energy-Conserving Carbon Monoxide Dehydrogenase Complex in the Hyperthermophile Pyrococcus furiosus.	Schut GJ, Lipscomb GL, Nguyen DM, Kelly RM, Adams MW.	Front Microbiol	10.3389/fmicb.2016.00029	2016
	Random mutagenesis of the hyperthermophilic archaeon Pyrococcus furiosus using in vitro mariner transposition and natural transformation.	Guschinskaya N, Brunel R, Tourte M, Lipscomb GL, Adams MWW, Oger P, Charpentier X.	Sci Rep	10.1038/srep36711	2016
Genetics	Perfect Match Genomic Landscape strategy: Refinement and customization of reference genomes.	Palacios-Flores K, Garcia-Sotelo J, Castillo A, Uribe C, Morales L, Boege M, Davila G, Flores M, Palacios R.	Proc Natl Acad Sci U S A	10.1073/pnas.2025192118	2021
Metabolism	Ethanol production by the hyperthermophilic archaeon Pyrococcus furiosus by expression of bacterial bifunctional alcohol dehydrogenases.	Keller MW, Lipscomb GL, Nguyen DM, Crowley AT, Schut GJ, Scott I, Kelly RM, Adams MWW.	Microb Biotechnol	10.1111/1751-7915.12486	2017
Phylogeny	Experimental and computational analysis of the secretome of the hyperthermophilic archaeon Pyrococcus furiosus.	Schmid G, Mathiesen G, Arntzen MO, Eijsink VG, Thomm M.	Extremophiles	10.1007/s00792-013-0574-0	2013
	The RNA- and DNA-targeting CRISPR-Cas immune systems of Pyrococcus furiosus.	Terns RM, Terns MP.	Biochem Soc Trans	10.1042/bst20130056	2013
	Phobos LIFE (Living Interplanetary Flight Experiment).	Betts BH, Warmflash D, Fraze RE, Friedman L, Vorobyova E, Lilburn TG, Smith A, Rettberg P, Jonsson KI, Ciftcioglu N, Fox GE, Svitek T, Kirschvinck JL, Moeller R, Wassmann M, Berger T.	Astrobiology	10.1089/ast.2018.1904	2019
	Synergistic production of 20(S)-protopanaxadiol from protopanaxadiol-type ginsenosides by beta-glycosidases from Dictyoglomus turgidum and Caldicellulosiruptor bescii.	Choi JH, Seo MJ, Shin KC, Lee KW, Oh DK.	AMB Express	10.1186/s13568-017-0524-9	2017
Enzymology	Thermostable Bacterial Collagenolytic Proteases: A Review.	Zhang K, Han Y.	J Microbiol Biotechnol	10.4014/jmb.2404.04051	2024
	A Genetic System for Methanocaldococcus jannaschii: An Evolutionary Deeply Rooted Hyperthermophilic Methanarchaeon.	Susanti D, Frazier MC, Mukhopadhyay B.	Front Microbiol	10.3389/fmicb.2019.01256	2019
Metabolism	PCNA is involved in the EndoQ-mediated DNA repair process in Thermococcales.	Shiraishi M, Ishino S, Yoshida K, Yamagami T, Cann I, Ishino Y.	Sci Rep	10.1038/srep25532	2016
Metabolism	An archaeal RNA binding protein, FAU-1, is a novel ribonuclease related to rRNA stability in Pyrococcus and Thermococcus.	Ikeda Y, Okada Y, Sato A, Kanai T, Tomita M, Atomi H, Kanai A.	Sci Rep	10.1038/s41598-017-13062-3	2017
Enzymology	Proteomics of Pyrococcus furiosus (Pfu): Identification of Extracted Proteins by Three Independent Methods.	Wong CC, Cociorva D, Miller CA, Schmidt A, Monell C, Aebersold R, Yates JR.	J Proteome Res	10.1021/pr300840j	2013
Metabolism	Engineering a hyperthermophilic archaeon for temperature-dependent product formation.	Basen M, Sun J, Adams MW, Adams MW.	mBio	10.1128/mbio.00053-12	2012
Metabolism	N-Linked Glycans Are Assembled on Highly Reduced Dolichol Phosphate Carriers in the Hyperthermophilic Archaea Pyrococcus furiosus.	Chang MM, Imperiali B, Eichler J, Guan Z.	PLoS One	10.1371/journal.pone.0130482	2015
Metabolism	Structural basis for dolichylphosphate mannose biosynthesis.	Gandini R, Reichenbach T, Tan TC, Divne C.	Nat Commun	10.1038/s41467-017-00187-2	2017
Metabolism	TK1211 Encodes an Amino Acid Racemase towards Leucine and Methionine in the Hyperthermophilic Archaeon Thermococcus kodakarensis.	Zheng RC, Lu XF, Tomita H, Hachisuka SI, Zheng YG, Atomi H.	J Bacteriol	10.1128/jb.00617-20	2021
	Transcription start site associated RNAs (TSSaRNAs) are ubiquitous in all domains of life.	Zaramela LS, Vencio RZ, ten-Caten F, Baliga NS, Koide T.	PLoS One	10.1371/journal.pone.0107680	2014
Metabolism	Genetic engineering of Pyrococcus furiosus to use chitin as a carbon source.	Kreuzer M, Schmutzler K, Waege I, Thomm M, Hausner W.	BMC Biotechnol	10.1186/1472-6750-13-9	2013
Metabolism	Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter.	Steiner J, Sazanov L.	Elife	10.7554/elife.59407	2020
	Two Archaeal RecJ Nucleases from Methanocaldococcus jannaschii Show Reverse Hydrolysis Polarity: Implication to Their Unique Function in Archaea.	Yi GS, Song Y, Wang WW, Chen JN, Deng W, Cao W, Wang FP, Xiao X, Liu XP.	Genes (Basel)	10.3390/genes8090211	2017
Genetics	Comparative genomics reveals conserved positioning of essential genomic clusters in highly rearranged Thermococcales chromosomes.	Cossu M, Da Cunha V, Toffano-Nioche C, Forterre P, Oberto J.	Biochimie	10.1016/j.biochi.2015.07.008	2015
	Natural competence in the hyperthermophilic archaeon Pyrococcus furiosus facilitates genetic manipulation: construction of markerless deletions of genes encoding the two cytoplasmic hydrogenases.	Lipscomb GL, Stirrett K, Schut GJ, Yang F, Jenney FE, Scott RA, Adams MW, Adams MW, Westpheling J.	Appl Environ Microbiol	10.1128/aem.02624-10	2011
Enzymology	Coupled TLC and MALDI-TOF/MS analyses of the lipid extract of the hyperthermophilic archaeon Pyrococcus furiosus.	Lobasso S, Lopalco P, Angelini R, Vitale R, Huber H, Muller V, Corcelli A.	Archaea	10.1155/2012/957852	2012
Metabolism	Recombinant production and biochemical characterization of a hyperthermostable alpha-glucan/maltodextrin phosphorylase from Pyrococcus furiosus.	Mizanur RM, Griffin AK, Pohl NL.	Archaea	10.1155/2008/549759	2008
	Gene order phylogeny and the evolution of methanogens.	Luo H, Sun Z, Arndt W, Shi J, Friedman R, Tang J.	PLoS One	10.1371/journal.pone.0006069	2009
Metabolism	Cellular Viscosity in Prokaryotes and Thermal Stability of Low Molecular Weight Biomolecules.	Cuecas A, Cruces J, Galisteo-Lopez JF, Peng X, Gonzalez JM.	Biophys J	10.1016/j.bpj.2016.07.024	2016
Metabolism	Homologous expression of a subcomplex of Pyrococcus furiosus hydrogenase that interacts with pyruvate ferredoxin oxidoreductase.	Hopkins RC, Sun J, Jenney FE, Chandrayan SK, McTernan PM, Adams MW, Adams MW.	PLoS One	10.1371/journal.pone.0026569	2011
	funRNA: a fungi-centered genomics platform for genes encoding key components of RNAi.	Choi J, Kim KT, Jeon J, Wu J, Song H, Asiegbu FO, Lee YH.	BMC Genomics	10.1186/1471-2164-15-s9-s14	2014
	Structure Principles of CRISPR-Cas Surveillance and Effector Complexes.	Tsui TK, Li H.	Annu Rev Biophys	10.1146/annurev-biophys-060414-033939	2015
Metabolism	Regulation of iron metabolism by Pyrococcus furiosus.	Zhu Y, Kumar S, Menon AL, Scott RA, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.02280-12	2013
	Expression, Purification, and Characterisation of Dehydroquinate Synthase from Pyrococcus furiosus.	Negron L, Patchett ML, Parker EJ.	Enzyme Res	10.4061/2011/134893	2011
	Recombinogenic properties of Pyrococcus furiosus strain COM1 enable rapid selection of targeted mutants.	Farkas J, Stirrett K, Lipscomb GL, Nixon W, Scott RA, Adams MW, Adams MW, Westpheling J.	Appl Environ Microbiol	10.1128/aem.00936-12	2012
	Single gene insertion drives bioalcohol production by a thermophilic archaeon.	Basen M, Schut GJ, Nguyen DM, Lipscomb GL, Benn RA, Prybol CJ, Vaccaro BJ, Poole FL, Kelly RM, Adams MW, Adams MW.	Proc Natl Acad Sci U S A	10.1073/pnas.1413789111	2014
Enzymology	Intact functional fourteen-subunit respiratory membrane-bound [NiFe]-hydrogenase complex of the hyperthermophilic archaeon Pyrococcus furiosus.	McTernan PM, Chandrayan SK, Wu CH, Vaccaro BJ, Lancaster WA, Yang Q, Fu D, Hura GL, Tainer JA, Adams MW, Adams MW.	J Biol Chem	10.1074/jbc.m114.567255	2014
Metabolism	A thermostable hybrid cluster protein from Pyrococcus furiosus: effects of the loss of a three helix bundle subdomain.	Overeijnder ML, Hagen WR, Hagedoorn PL.	J Biol Inorg Chem	10.1007/s00775-009-0483-y	2009
	The L7Ae protein binds to two kink-turns in the Pyrococcus furiosus RNase P RNA.	Lai SM, Lai LB, Foster MP, Gopalan V.	Nucleic Acids Res	10.1093/nar/gku994	2014
Genetics	Novel archaeal thermostable cellulases from an oil reservoir metagenome.	Lewin A, Zhou J, Pham VTT, Haugen T, Zeiny ME, Aarstad O, Liebl W, Wentzel A, Liles MR.	AMB Express	10.1186/s13568-017-0485-z	2017
Enzymology	Engineering hydrogen gas production from formate in a hyperthermophile by heterologous production of an 18-subunit membrane-bound complex.	Lipscomb GL, Schut GJ, Thorgersen MP, Nixon WJ, Kelly RM, Adams MW, Adams MW.	J Biol Chem	10.1074/jbc.m113.530725	2014
Enzymology	Structural Insight into Ubiquitin-Like Protein Recognition and Oligomeric States of JAMM/MPN⁺ Proteases.	Cao S, Engilberge S, Girard E, Gabel F, Franzetti B, Maupin-Furlow JA.	Structure	10.1016/j.str.2017.04.002	2017
	Defining components of the chromosomal origin of replication of the hyperthermophilic archaeon Pyrococcus furiosus needed for construction of a stable replicating shuttle vector.	Farkas J, Chung D, DeBarry M, Adams MW, Adams MW, Westpheling J.	Appl Environ Microbiol	10.1128/aem.05057-11	2011
	Phylogeny and Taxonomy of Archaea: A Comparison of the Whole-Genome-Based CVTree Approach with 16S rRNA Sequence Analysis.	Zuo G, Xu Z, Hao B.	Life (Basel)	10.3390/life5010949	2015
Phylogeny	A virus of hyperthermophilic archaea with a unique architecture among DNA viruses.	Rensen EI, Mochizuki T, Quemin E, Schouten S, Krupovic M, Prangishvili D.	Proc Natl Acad Sci U S A	10.1073/pnas.1518929113	2016
Enzymology	Enzymatic reactions towards aldehydes: An overview.	Schober L, Dobiasova H, Jurkas V, Parmeggiani F, Rudroff F, Winkler M.	Flavour Fragr J	10.1002/ffj.3739	2023
Enzymology	A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.	Forouhar F, Saadat N, Hussain M, Seetharaman J, Lee I, Janjua H, Xiao R, Shastry R, Acton TB, Montelione GT, Tong L.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309111031447	2011
Genetics	Inteins as indicators of gene flow in the halobacteria.	Soucy SM, Fullmer MS, Papke RT, Gogarten JP.	Front Microbiol	10.3389/fmicb.2014.00299	2014
Enzymology	Development of novel sugar isomerases by optimization of active sites in phosphosugar isomerases for monosaccharides.	Yeom SJ, Kim YS, Oh DK.	Appl Environ Microbiol	10.1128/aem.02539-12	2013
Metabolism	Metabolic Adaptation to Sulfur of Hyperthermophilic Palaeococcus pacificus DY20341^T from Deep-Sea Hydrothermal Sediments.	Zeng X, Zhang X, Shao Z.	Int J Mol Sci	10.3390/ijms21010368	2020
	A Reexamination of Thioredoxin Reductase from Thermoplasma acidophilum, a Thermoacidophilic Euryarchaeon, Identifies It as an NADH-Dependent Enzyme.	Susanti D, Loganathan U, Compton A, Mukhopadhyay B.	ACS Omega	10.1021/acsomega.7b00640	2017
Metabolism	Reinvestigation of the steady-state kinetics and physiological function of the soluble NiFe-hydrogenase I of Pyrococcus furiosus.	van Haaster DJ, Silva PJ, Hagedoorn PL, Jongejan JA, Hagen WR.	J Bacteriol	10.1128/jb.01562-07	2008
Metabolism	Endonuclease V: an unusual enzyme for repair of DNA deamination.	Cao W.	Cell Mol Life Sci	10.1007/s00018-012-1222-z	2013
Metabolism	A Phosphofructokinase Homolog from Pyrobaculum calidifontis Displays Kinase Activity towards Pyrimidine Nucleosides and Ribose 1-Phosphate.	Aziz I, Bibi T, Rashid N, Aono R, Atomi H, Akhtar M.	J Bacteriol	10.1128/jb.00284-18	2018
Metabolism	Molybdenum incorporation in tungsten aldehyde oxidoreductase enzymes from Pyrococcus furiosus.	Sevcenco AM, Bevers LE, Pinkse MW, Krijger GC, Wolterbeek HT, Verhaert PD, Hagen WR, Hagedoorn PL.	J Bacteriol	10.1128/jb.00270-10	2010
Metabolism	Mercury methylation by the methanogen Methanospirillum hungatei.	Yu RQ, Reinfelder JR, Hines ME, Barkay T.	Appl Environ Microbiol	10.1128/aem.01556-13	2013
Metabolism	The Prodigal Compound: Return of Ribosyl 1,5-Bisphosphate as an Important Player in Metabolism.	Hove-Jensen B, Brodersen DE, Manav MC.	Microbiol Mol Biol Rev	10.1128/mmbr.00040-18	2019
Pathogenicity	Antimicrobial activity of the iron-sulfur nitroso compound Roussin's black salt [Fe4S3(NO)7] on the hyperthermophilic archaeon Pyrococcus furiosus.	Hamilton-Brehm SD, Schut GJ, Adams MW, Adams MW.	Appl Environ Microbiol	10.1128/aem.02562-08	2009
Genetics	Novel Ethanol- and 5-Hydroxymethyl Furfural-Stimulated beta-Glucosidase Retrieved From a Brazilian Secondary Atlantic Forest Soil Metagenome.	Alves LF, Meleiro LP, Silva RN, Westmann CA, Guazzaroni ME.	Front Microbiol	10.3389/fmicb.2018.02556	2018
Genetics	Genomic arrangement of bacterial operons is constrained by biological pathways encoded in the genome.	Yin Y, Zhang H, Olman V, Xu Y.	Proc Natl Acad Sci U S A	10.1073/pnas.0911237107	2010
Genetics	Expanded Phylogenetic Diversity and Metabolic Flexibility of Mercury-Methylating Microorganisms.	McDaniel EA, Peterson BD, Stevens SLR, Tran PQ, Anantharaman K, McMahon KD.	mSystems	10.1128/msystems.00299-20	2020
	Predicting candidate genomic sequences that correspond to synthetic functional RNA motifs.	Laserson U, Gan HH, Schlick T.	Nucleic Acids Res	10.1093/nar/gki911	2005
Metabolism	AglB, catalyzing the oligosaccharyl transferase step of the archaeal N-glycosylation process, is essential in the thermoacidophilic crenarchaeon Sulfolobus acidocaldarius.	Meyer BH, Albers SV.	Microbiologyopen	10.1002/mbo3.185	2014
Metabolism	Staphylococcus aureus and Pseudomonas aeruginosa express and secrete human surfactant proteins.	Brauer L, Schicht M, Worlitzsch D, Bensel T, Sawers RG, Paulsen F.	PLoS One	10.1371/journal.pone.0053705	2013
Genetics	Genome sequencing of a genetically tractable Pyrococcus furiosus strain reveals a highly dynamic genome.	Bridger SL, Lancaster WA, Poole FL, Schut GJ, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.00439-12	2012
	Argonaute protein as a linker to command center of physiological processes.	Wei K, Wu L, Chen Y, Lin Y, Wang Y, Liu X, Xie D.	Chin J Cancer Res	10.3978/j.issn.1000-9604.2013.08.13	2013
	Structure of Pfu Pop5, an archaeal RNase P protein.	Wilson RC, Bohlen CJ, Foster MP, Bell CE.	Proc Natl Acad Sci U S A	10.1073/pnas.0508004103	2006
Phylogeny	A proposal to rename the hyperthermophile Pyrococcus woesei as Pyrococcus furiosus subsp. woesei.	Kanoksilapatham W, Gonzalez JM, Maeder DL, DiRuggiero J, Robb FT.	Archaea	10.1155/2004/513563	2004
	tRNAscan-SE 2.0: improved detection and functional classification of transfer RNA genes.	Chan PP, Lin BY, Mak AJ, Lowe TM.	Nucleic Acids Res	10.1093/nar/gkab688	2021
	Functional Screening of Hydrolytic Activities Reveals an Extremely Thermostable Cellulase from a Deep-Sea Archaeon.	Leis B, Heinze S, Angelov A, Pham VT, Thurmer A, Jebbar M, Golyshin PN, Streit WR, Daniel R, Liebl W.	Front Bioeng Biotechnol	10.3389/fbioe.2015.00095	2015
Metabolism	Role of the beta1 subunit in the function and stability of the 20S proteasome in the hyperthermophilic archaeon Pyrococcus furiosus.	Madding LS, Michel JK, Shockley KR, Conners SB, Epting KL, Johnson MR, Kelly RM.	J Bacteriol	10.1128/jb.01382-06	2007
Metabolism	Development and Validation of Broad-Range Qualitative and Clade-Specific Quantitative Molecular Probes for Assessing Mercury Methylation in the Environment.	Christensen GA, Wymore AM, King AJ, Podar M, Hurt RA, Santillan EU, Soren A, Brandt CC, Brown SD, Palumbo AV, Wall JD, Gilmour CC, Elias DA.	Appl Environ Microbiol	10.1128/aem.01271-16	2016
	Modular architecture of metabolic pathways revealed by conserved sequences of reactions.	Muto A, Kotera M, Tokimatsu T, Nakagawa Z, Goto S, Kanehisa M.	J Chem Inf Model	10.1021/ci3005379	2013
	Isolation and Characterization of the First Xylanolytic Hyperthermophilic Euryarchaeon Thermococcus sp. Strain 2319x1 and Its Unusual Multidomain Glycosidase.	Gavrilov SN, Stracke C, Jensen K, Menzel P, Kallnik V, Slesarev A, Sokolova T, Zayulina K, Brasen C, Bonch-Osmolovskaya EA, Peng X, Kublanov IV, Siebers B.	Front Microbiol	10.3389/fmicb.2016.00552	2016
Enzymology	Crystallization and preliminary X-ray characterization of a ferritin from the hyperthermophilic archaeon and anaerobe Pyrococcus furiosus.	Matias PM, Tatur J, Carrondo MA, Hagen WR.	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/s1744309105011516	2005
Enzymology	Reconstructed ancestral Myo-inositol-3-phosphate synthases indicate that ancestors of the Thermococcales and Thermotoga species were more thermophilic than their descendants.	Butzin NC, Lapierre P, Green AG, Swithers KS, Gogarten JP, Noll KM.	PLoS One	10.1371/journal.pone.0084300	2013
Enzymology	A steady-state and pre-steady-state kinetics study of the tungstoenzyme formaldehyde ferredoxin oxidoreductase from Pyrococcus furiosus.	Bol E, Broers NJ, Hagen WR.	J Biol Inorg Chem	10.1007/s00775-007-0301-3	2008
	Stationary phase and nutrient levels trigger transcription of a genomic locus containing a novel peptide (TM1316) in the hyperthermophilic bacterium Thermotoga maritima.	Frock AD, Montero CI, Blumer-Schuette SE, Kelly RM.	Appl Environ Microbiol	10.1128/aem.01627-13	2013
Metabolism	Linking genome content to biofuel production yields: a meta-analysis of major catabolic pathways among select H2 and ethanol-producing bacteria.	Carere CR, Rydzak T, Verbeke TJ, Cicek N, Levin DB, Sparling R.	BMC Microbiol	10.1186/1471-2180-12-295	2012
Metabolism	Biochemical evidence for the presence of two alpha-glucoside ABC-transport systems in the hyperthermophilic archaeon Pyrococcus furiosus.	Koning SM, Konings WN, Driessen AJ.	Archaea	10.1155/2002/529610	2002
	Crystal structure of the probable haloacid dehalogenase PH0459 from Pyrococcus horikoshii OT3.	Arai R, Kukimoto-Niino M, Kuroishi C, Bessho Y, Shirouzu M, Yokoyama S.	Protein Sci	10.1110/ps.051922406	2006
Metabolism	WOR5, a novel tungsten-containing aldehyde oxidoreductase from Pyrococcus furiosus with a broad substrate Specificity.	Bevers LE, Bol E, Hagedoorn PL, Hagen WR.	J Bacteriol	10.1128/jb.187.20.7056-7061.2005	2005
Enzymology	Three-dimensional structure of A1A0 ATP synthase from the hyperthermophilic archaeon Pyrococcus furiosus by electron microscopy.	Vonck J, Pisa KY, Morgner N, Brutschy B, Muller V.	J Biol Chem	10.1074/jbc.m808498200	2009
Metabolism	A Structurally Novel Lipoyl Synthase in the Hyperthermophilic Archaeon Thermococcus kodakarensis.	Jin JQ, Hachisuka SI, Sato T, Fujiwara T, Atomi H.	Appl Environ Microbiol	10.1128/aem.01359-20	2020
Genetics	Functional Annotations of Paralogs: A Blessing and a Curse.	Zallot R, Harrison KJ, Kolaczkowski B, de Crecy-Lagard V.	Life (Basel)	10.3390/life6030039	2016
	Diversity of CRISPR-Cas immune systems and molecular machines.	Barrangou R.	Genome Biol	10.1186/s13059-015-0816-9	2015
Enzymology	A novel branching enzyme of the GH-57 family in the hyperthermophilic archaeon Thermococcus kodakaraensis KOD1.	Murakami T, Kanai T, Takata H, Kuriki T, Imanaka T.	J Bacteriol	10.1128/jb.00390-06	2006
Metabolism	Transcriptional and biochemical analysis of starch metabolism in the hyperthermophilic archaeon Pyrococcus furiosus.	Lee HS, Shockley KR, Schut GJ, Conners SB, Montero CI, Johnson MR, Chou CJ, Bridger SL, Wigner N, Brehm SD, Jenney FE, Comfort DA, Kelly RM, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.188.6.2115-2125.2006	2006
Genetics	Extensive genome rearrangements and multiple horizontal gene transfers in a population of pyrococcus isolates from Vulcano Island, Italy.	White JR, Escobar-Paramo P, Mongodin EF, Nelson KE, DiRuggiero J.	Appl Environ Microbiol	10.1128/aem.01024-08	2008
Metabolism	Insights into the maturation of hyperthermophilic pyrolysin and the roles of its N-terminal propeptide and long C-terminal extension.	Dai Z, Fu H, Zhang Y, Zeng J, Tang B, Tang XF.	Appl Environ Microbiol	10.1128/aem.00548-12	2012
Genetics	Ori-Finder 2, an integrated tool to predict replication origins in the archaeal genomes.	Luo H, Zhang CT, Gao F.	Front Microbiol	10.3389/fmicb.2014.00482	2014
Enzymology	hypD as a marker for [NiFe]-hydrogenases in microbial communities of surface waters.	Beimgraben C, Gutekunst K, Opitz F, Appel J.	Appl Environ Microbiol	10.1128/aem.00690-14	2014
Enzymology	Hydrogen Production and Enzyme Activities in the Hyperthermophile Thermococcus paralvinellae Grown on Maltose, Tryptone, and Agricultural Waste.	Hensley SA, Moreira E, Holden JF.	Front Microbiol	10.3389/fmicb.2016.00167	2016
Pathogenicity	Pseudomonas stutzeri as an alternative host for membrane proteins.	Sommer M, Xie H, Michel H.	Microb Cell Fact	10.1186/s12934-017-0771-0	2017
Metabolism	Molecular analysis of the role of two aromatic aminotransferases and a broad-specificity aspartate aminotransferase in the aromatic amino acid metabolism of Pyrococcus furiosus.	Ward DE, de Vos WM, van der Oost J.	Archaea	10.1155/2002/959031	2002
Metabolism	Enzymatic analysis of an amylolytic enzyme from the hyperthermophilic archaeon Pyrococcus furiosus reveals its novel catalytic properties as both an alpha-amylase and a cyclodextrin-hydrolyzing enzyme.	Yang SJ, Lee HS, Park CS, Kim YR, Moon TW, Park KH.	Appl Environ Microbiol	10.1128/aem.70.10.5988-5995.2004	2004
Metabolism	Phylogenomic reconstruction of archaeal fatty acid metabolism.	Dibrova DV, Galperin MY, Mulkidjanian AY.	Environ Microbiol	10.1111/1462-2920.12359	2014
	Flagella of Pyrococcus furiosus: multifunctional organelles, made for swimming, adhesion to various surfaces, and cell-cell contacts.	Nather DJ, Rachel R, Wanner G, Wirth R.	J Bacteriol	10.1128/jb.00527-06	2006
Enzymology	Characterization of a fourth tungsten-containing enzyme from the hyperthermophilic archaeon Pyrococcus furiosus.	Roy R, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.184.24.6952-6956.2002	2002
Genetics	Sequence evidence in the archaeal genomes that tRNAs emerged through the combination of ancestral genes as 5' and 3' tRNA halves.	Fujishima K, Sugahara J, Tomita M, Kanai A.	PLoS One	10.1371/journal.pone.0001622	2008
	Thermostable tag (TST) protein expression system: engineering thermotolerant recombinant proteins and vaccines.	Luke JM, Carnes AE, Sun P, Hodgson CP, Waugh DS, Williams JA.	J Biotechnol	10.1016/j.jbiotec.2010.12.011	2011
Enzymology	Biochemical adaptations of two sugar kinases from the hyperthermophilic archaeon Pyrococcus furiosus.	Verhees CH, Koot DG, Ettema TJ, Dijkema C, de Vos WM, van der Oost J.	Biochem J	10.1042/bj20011597	2002
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Metabolism	N-terminal fusion of a hyperthermophilic chitin-binding domain to xylose isomerase from Thermotoga neapolitana enhances kinetics and thermostability of both free and immobilized enzymes.	Harris JM, Epting KL, Kelly RM.	Biotechnol Prog	10.1002/btpr.416	2010
Metabolism	Analysis of the enzymatic properties of a broad family of alanine aminotransferases.	McAllister CH, Facette M, Holt A, Good AG.	PLoS One	10.1371/journal.pone.0055032	2013
Enzymology	A c subunit with four transmembrane helices and one ion (Na+)-binding site in an archaeal ATP synthase: implications for c ring function and structure.	Mayer F, Leone V, Langer JD, Faraldo-Gomez JD, Muller V.	J Biol Chem	10.1074/jbc.m112.411223	2012
Metabolism	Rubrerythrin from the hyperthermophilic archaeon Pyrococcus furiosus is a rubredoxin-dependent, iron-containing peroxidase.	Weinberg MV, Jenney FE, Cui X, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.186.23.7888-7895.2004	2004
Enzymology	Specific bacterial, archaeal, and eukaryotic communities in tidal-flat sediments along a vertical profile of several meters.	Wilms R, Sass H, Kopke B, Koster J, Cypionka H, Engelen B.	Appl Environ Microbiol	10.1128/aem.72.4.2756-2764.2006	2006
Metabolism	Novel multiprotein complexes identified in the hyperthermophilic archaeon Pyrococcus furiosus by non-denaturing fractionation of the native proteome.	Menon AL, Poole FL, Cvetkovic A, Trauger SA, Kalisiak E, Scott JW, Shanmukh S, Praissman J, Jenney FE, Wikoff WR, Apon JV, Siuzdak G, Adams MW, Adams MW.	Mol Cell Proteomics	10.1074/mcp.m800246-mcp200	2009
Enzymology	Cloning and recombinant expression of a cellulase from the cellulolytic strain Streptomyces sp. G12 isolated from compost.	Amore A, Pepe O, Ventorino V, Birolo L, Giangrande C, Faraco V.	Microb Cell Fact	10.1186/1475-2859-11-164	2012
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Enzymology	A hyperactive NAD(P)H:Rubredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus.	Ma K, Adams MW.	J Bacteriol	10.1128/jb.181.17.5530-5533.1999	1999
Metabolism	Genetic tool development underpins recent advances in thermophilic whole-cell biocatalysts.	Taylor MP, van Zyl L, Tuffin IM, Leak DJ, Cowan DA.	Microb Biotechnol	10.1111/j.1751-7915.2010.00246.x	2011
Genetics	Identification and genomic analysis of transcription factors in archaeal genomes exemplifies their functional architecture and evolutionary origin.	Perez-Rueda E, Janga SC.	Mol Biol Evol	10.1093/molbev/msq033	2010
Metabolism	Characterization of a novel zinc-containing, lysine-specific aminopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus.	Story SV, Shah C, Jenney FE, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.187.6.2077-2083.2005	2005
Metabolism	Mining for novel cyclomaltodextrin glucanotransferases unravels the carbohydrate metabolism pathway via cyclodextrins in Thermoanaerobacterales.	Centeno-Leija S, Espinosa-Barrera L, Velazquez-Cruz B, Cardenas-Conejo Y, Virgen-Ortiz R, Valencia-Cruz G, Saenz RA, Marin-Tovar Y, Gomez-Manzo S, Hernandez-Ochoa B, Rocha-Ramirez LM, Zatarain-Palacios R, Osuna-Castro JA, Lopez-Munguia A, Serrano-Posada H.	Sci Rep	10.1038/s41598-021-04569-x	2022
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	Purification and Characterization of a Proteasome from the Hyperthermophilic Archaeon Pyrococcus furiosus.	Bauer MW, Bauer SH, Kelly RM.	Appl Environ Microbiol	10.1128/aem.63.3.1160-1164.1997	1997
Metabolism	Heat shock response by the hyperthermophilic archaeon Pyrococcus furiosus.	Shockley KR, Ward DE, Chhabra SR, Conners SB, Montero CI, Kelly RM.	Appl Environ Microbiol	10.1128/aem.69.4.2365-2371.2003	2003
Metabolism	Heterologous expression and maturation of an NADP-dependent [NiFe]-hydrogenase: a key enzyme in biofuel production.	Sun J, Hopkins RC, Jenney FE, McTernan PM, Adams MW, Adams MW.	PLoS One	10.1371/journal.pone.0010526	2010
Enzymology	Acetyl coenzyme A synthetase (ADP forming) from the hyperthermophilic Archaeon pyrococcus furiosus: identification, cloning, separate expression of the encoding genes, acdAI and acdBI, in Escherichia coli, and in vitro reconstitution of the active heterotetrameric enzyme from its recombinant subunits.	Musfeldt M, Selig M, Schonheit P.	J Bacteriol	10.1128/jb.181.18.5885-5888.1999	1999
Metabolism	Cellobiose uptake in the hyperthermophilic archaeon Pyrococcus furiosus is mediated by an inducible, high-affinity ABC transporter.	Koning SM, Elferink MG, Konings WN, Driessen AJ.	J Bacteriol	10.1128/jb.183.17.4979-4984.2001	2001
Metabolism	Insights into the metabolism of elemental sulfur by the hyperthermophilic archaeon Pyrococcus furiosus: characterization of a coenzyme A- dependent NAD(P)H sulfur oxidoreductase.	Schut GJ, Bridger SL, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.00031-07	2007
	Divergence of the hyperthermophilic archaea Pyrococcus furiosus and P. horikoshii inferred from complete genomic sequences.	Maeder DL, Weiss RB, Dunn DM, Cherry JL, Gonzalez JM, DiRuggiero J, Robb FT.	Genetics	10.1093/genetics/152.4.1299	1999
	Molecular characterization of the genes encoding the tungsten-containing aldehyde ferredoxin oxidoreductase from Pyrococcus furiosus and formaldehyde ferredoxin oxidoreductase from Thermococcus litoralis.	Kletzin A, Mukund S, Kelley-Crouse TL, Chan MK, Rees DC, Adams MW.	J Bacteriol	10.1128/jb.177.16.4817-4819.1995	1995
	Extreme resistance to thermally induced DNA backbone breaks in the hyperthermophilic archaeon Pyrococcus furiosus.	Peak MJ, Robb FT, Peak JG.	J Bacteriol	10.1128/jb.177.21.6316-6318.1995	1995
Metabolism	NotI passporting to identify species composition of complex microbial systems.	Zabarovska V, Kutsenko AS, Petrenko L, Kilosanidze G, Ljungqvist O, Norin E, Midtvedt T, Winberg G, Mollby R, Kashuba VI, Kashuba VI, Ernberg I, Zabarovsky ER.	Nucleic Acids Res	10.1093/nar/gng005	2003
Metabolism	Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions.	Tan DX, Zheng X, Kong J, Manchester LC, Hardeland R, Kim SJ, Xu X, Reiter RJ.	Int J Mol Sci	10.3390/ijms150915858	2014
Enzymology	Novel type of glucose-6-phosphate isomerase in the hyperthermophilic archaeon Pyrococcus furiosus.	Hansen T, Oehlmann M, Schonheit P.	J Bacteriol	10.1128/jb.183.11.3428-3435.2001	2001
	Development of the Multiple Gene Knockout System with One-Step PCR in Thermoacidophilic Crenarchaeon Sulfolobus acidocaldarius.	Suzuki S, Kurosawa N.	Archaea	10.1155/2017/7459310	2017
Enzymology	Discovery of a widely distributed toxin biosynthetic gene cluster.	Lee SW, Mitchell DA, Markley AL, Hensler ME, Gonzalez D, Wohlrab A, Dorrestein PC, Nizet V, Dixon JE.	Proc Natl Acad Sci U S A	10.1073/pnas.0801338105	2008
Transcriptome	Network analyses structure genetic diversity in independent genetic worlds.	Halary S, Leigh JW, Cheaib B, Lopez P, Bapteste E.	Proc Natl Acad Sci U S A	10.1073/pnas.0908978107	2010
	Carboxylic ester hydrolases from hyperthermophiles.	Levisson M, van der Oost J, Kengen SW.	Extremophiles	10.1007/s00792-009-0260-4	2009
Metabolism	Transfer RNA modification enzymes from Pyrococcus furiosus: detection of the enzymatic activities in vitro.	Constantinesco F, Motorin Y, Grosjean H.	Nucleic Acids Res	10.1093/nar/27.5.1308	1999
Metabolism	The bifunctional pyruvate decarboxylase/pyruvate ferredoxin oxidoreductase from Thermococcus guaymasensis.	Eram MS, Oduaran E, Ma K.	Archaea	10.1155/2014/349379	2014
Enzymology	Ribonucleotide reductase in the archaeon Pyrococcus furiosus: a critical enzyme in the evolution of DNA genomes?	Riera J, Robb FT, Weiss R, Fontecave M.	Proc Natl Acad Sci U S A	10.1073/pnas.94.2.475	1997
Metabolism	Sequence, expression in Escherichia coli, and analysis of the gene encoding a novel intracellular protease (PfpI) from the hyperthermophilic archaeon Pyrococcus furiosus.	Halio SB, Blumentals II, Short SA, Merrill BM, Kelly RM.	J Bacteriol	10.1128/jb.178.9.2605-2612.1996	1996
Enzymology	Phosphoenolpyruvate synthetase from the hyperthermophilic archaeon Pyrococcus furiosus.	Hutchins AM, Holden JF, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.183.2.709-715.2001	2001
	A simple energy-conserving system: proton reduction coupled to proton translocation.	Sapra R, Bagramyan K, Adams MW, Adams MW.	Proc Natl Acad Sci U S A	10.1073/pnas.1331436100	2003
	Characterization of UDP amino sugars as major phosphocompounds in the hyperthermophilic archaeon Pyrococcus furiosus.	Ramakrishnan V, Teng Q, Adams MW.	J Bacteriol	10.1128/jb.179.5.1505-1512.1997	1997
Metabolism	Distribution analysis of hydrogenases in surface waters of marine and freshwater environments.	Barz M, Beimgraben C, Staller T, Germer F, Opitz F, Marquardt C, Schwarz C, Gutekunst K, Vanselow KH, Schmitz R, LaRoche J, Schulz R, Appel J.	PLoS One	10.1371/journal.pone.0013846	2010
	Evolutionary history of the TBP-domain superfamily.	Brindefalk B, Dessailly BH, Yeats C, Orengo C, Werner F, Poole AM.	Nucleic Acids Res	10.1093/nar/gkt045	2013
Phylogeny	The dispersed archaeal eukaryome and the complex archaeal ancestor of eukaryotes.	Koonin EV, Yutin N.	Cold Spring Harb Perspect Biol	10.1101/cshperspect.a016188	2014
Enzymology	Distribution and phylogenies of enzymes of the Embden-Meyerhof-Parnas pathway from archaea and hyperthermophilic bacteria support a gluconeogenic origin of metabolism.	Ronimus RS, Morgan HW.	Archaea	10.1155/2003/162593	2003
Metabolism	SurR: a transcriptional activator and repressor controlling hydrogen and elemental sulphur metabolism in Pyrococcus furiosus.	Lipscomb GL, Keese AM, Cowart DM, Schut GJ, Thomm M, Adams MW, Adams MW, Scott RA.	Mol Microbiol	10.1111/j.1365-2958.2008.06525.x	2009
	Accumulation of Mannosylglycerate and Di-myo-Inositol-Phosphate by Pyrococcus furiosus in Response to Salinity and Temperature.	Martins LO, Santos H.	Appl Environ Microbiol	10.1128/aem.61.9.3299-3303.1995	1995
Enzymology	The tRNA(guanine-26,N2-N2) methyltransferase (Trm1) from the hyperthermophilic archaeon Pyrococcus furiosus: cloning, sequencing of the gene and its expression in Escherichia coli.	Constantinesco F, Benachenhou N, Motorin Y, Grosjean H.	Nucleic Acids Res	10.1093/nar/26.16.3753	1998
Metabolism	Relationship between glycosyl hydrolase inventory and growth physiology of the hyperthermophile Pyrococcus furiosus on carbohydrate-based media.	Driskill LE, Kusy K, Bauer MW, Kelly RM.	Appl Environ Microbiol	10.1128/aem.65.3.893-897.1999	1999
Metabolism	Metabolic and evolutionary relationships among Pyrococcus Species: genetic exchange within a hydrothermal vent environment.	Hamilton-Brehm SD, Schut GJ, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.187.21.7492-7499.2005	2005
	Overexpression and characterization of a prolyl endopeptidase from the hyperthermophilic archaeon Pyrococcus furiosus.	Harwood VJ, Denson JD, Robinson-Bidle KA, Schreier HJ.	J Bacteriol	10.1128/jb.179.11.3613-3618.1997	1997
Enzymology	Purification and characterization of a membrane-bound hydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.	Sapra R, Verhagen MF, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.182.12.3423-3428.2000	2000
Metabolism	Transcriptional downregulation of rice rpL32 gene under abiotic stress is associated with removal of transcription factors within the promoter region.	Mukhopadhyay P, Reddy MK, Singla-Pareek SL, Sopory SK.	PLoS One	10.1371/journal.pone.0028058	2011
Enzymology	The beta-glucanase ZgLamA from Zobellia galactanivorans evolved a bent active site adapted for efficient degradation of algal laminarin.	Labourel A, Jam M, Jeudy A, Hehemann JH, Czjzek M, Michel G.	J Biol Chem	10.1074/jbc.m113.538843	2014
	Novel archaeal adhesion pilins with a conserved N terminus.	Esquivel RN, Xu R, Pohlschroder M.	J Bacteriol	10.1128/jb.00572-13	2013
Enzymology	Characterization of an aminoacylase from the hyperthermophilic archaeon Pyrococcus furiosus.	Story SV, Grunden AM, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.183.14.4259-4268.2001	2001
	Exploiting genomic patterns to discover new supramolecular protein assemblies.	Beeby M, Bobik TA, Yeates TO.	Protein Sci	10.1002/pro.1	2009
Metabolism	Enhanced butanol production obtained by reinforcing the direct butanol-forming route in Clostridium acetobutylicum.	Jang YS, Lee JY, Lee J, Park JH, Im JA, Eom MH, Lee J, Lee SH, Song H, Cho JH, Seung do Y, Lee SY.	mBio	10.1128/mbio.00314-12	2012
Enzymology	Purification and characterization of a cobalt-activated carboxypeptidase from the hyperthermophilic archaeon Pyrococcus furiosus.	Cheng TC, Ramakrishnan V, Chan SI.	Protein Sci	10.1110/ps.8.11.2474	1999
	Oxygen and hydrogen peroxide in the early evolution of life on earth: in silico comparative analysis of biochemical pathways.	Slesak I, Slesak H, Kruk J.	Astrobiology	10.1089/ast.2011.0704	2012
Enzymology	Cloning, sequencing, and expression of the gene encoding extracellular alpha-amylase from Pyrococcus furiosus and biochemical characterization of the recombinant enzyme.	Dong G, Vieille C, Savchenko A, Zeikus JG.	Appl Environ Microbiol	10.1128/aem.63.9.3569-3576.1997	1997
Metabolism	Key role for sulfur in peptide metabolism and in regulation of three hydrogenases in the hyperthermophilic archaeon Pyrococcus furiosus.	Adams MW, Adams MW, Holden JF, Menon AL, Schut GJ, Grunden AM, Hou C, Hutchins AM, Jenney FE, Kim C, Ma K, Pan G, Roy R, Sapra R, Story SV, Verhagen MF.	J Bacteriol	10.1128/jb.183.2.716-724.2001	2001
Enzymology	Purification and characterization of the alanine aminotransferase from the hyperthermophilic Archaeon pyrococcus furiosus and its role in alanine production.	Ward DE, Kengen SW, van Der Oost J, de Vos WM.	J Bacteriol	10.1128/jb.182.9.2559-2566.2000	2000
	Cold shock of a hyperthermophilic archaeon: Pyrococcus furiosus exhibits multiple responses to a suboptimal growth temperature with a key role for membrane-bound glycoproteins.	Weinberg MV, Schut GJ, Brehm S, Datta S, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.187.1.336-348.2005	2005
Enzymology	Expression and in vitro assembly of recombinant glutamate dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.	Diruggiero J, Robb FT.	Appl Environ Microbiol	10.1128/aem.61.1.159-164.1995	1995
Enzymology	Characterization of the celB gene coding for beta-glucosidase from the hyperthermophilic archaeon Pyrococcus furiosus and its expression and site-directed mutation in Escherichia coli.	Voorhorst WG, Eggen RI, Luesink EJ, de Vos WM.	J Bacteriol	10.1128/jb.177.24.7105-7111.1995	1995
Enzymology	Sulfolobus tokodaii ST0053 produces a novel thermostable, NAD-dependent medium-chain alcohol dehydrogenase.	Yanai H, Doi K, Ohshima T.	Appl Environ Microbiol	10.1128/aem.01392-08	2009
Phylogeny	Whole-genome based Archaea phylogeny and taxonomy: A composition vector approach.	Sun J, Xu Z, Hao B.	Chin Sci Bull	10.1007/s11434-010-3008-8	2010
	Cultivation Techniques for Hyperthermophilic Archaebacteria: Continuous Culture of Pyrococcus furiosus at Temperatures near 100 degrees C.	Brown SH, Kelly RM.	Appl Environ Microbiol	10.1128/aem.55.8.2086-2088.1989	1989
Metabolism	The ars detoxification system is advantageous but not required for As(V) respiration by the genetically tractable Shewanella species strain ANA-3.	Saltikov CW, Cifuentes A, Venkateswaran K, Newman DK.	Appl Environ Microbiol	10.1128/aem.69.5.2800-2809.2003	2003
Metabolism	Characterization of 2-ketoisovalerate ferredoxin oxidoreductase, a new and reversible coenzyme A-dependent enzyme involved in peptide fermentation by hyperthermophilic archaea.	Heider J, Mai X, Adams MW.	J Bacteriol	10.1128/jb.178.3.780-787.1996	1996
Metabolism	Whole-genome DNA microarray analysis of a hyperthermophile and an archaeon: Pyrococcus furiosus grown on carbohydrates or peptides.	Schut GJ, Brehm SD, Datta S, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.185.13.3935-3947.2003	2003
Metabolism	Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.	Ma K, Weiss R, Adams MW, Adams MW.	J Bacteriol	10.1128/jb.182.7.1864-1871.2000	2000
Metabolism	Voltammetric studies of the reactions of iron-sulphur clusters ([3Fe-4S] or [M3Fe-4S]) formed in Pyrococcus furiosus ferredoxin.	Fawcett SE, Davis D, Breton JL, Thomson AJ, Armstrong FA.	Biochem J	10.1042/bj3350357	1998
Enzymology	Pyruvate ferredoxin oxidoreductase from the hyperthermophilic archaeon, Pyrococcus furiosus, functions as a CoA-dependent pyruvate decarboxylase.	Ma K, Hutchins A, Sung SJ, Adams MW, Adams MW.	Proc Natl Acad Sci U S A	10.1073/pnas.94.18.9608	1997
Metabolism	Hydrogenase of the hyperthermophile Pyrococcus furiosus is an elemental sulfur reductase or sulfhydrogenase: evidence for a sulfur-reducing hydrogenase ancestor.	Ma K, Schicho RN, Kelly RM, Adams MW.	Proc Natl Acad Sci U S A	10.1073/pnas.90.11.5341	1993
	Identification of membrane proteins in the hyperthermophilic archaeon pyrococcus furiosus using proteomics and prediction programs.	Holden JF, Poole Ii FL, Tollaksen SL, Giometti CS, Lim H, Yates Iii JR, Adams MW, Adams MW.	Comp Funct Genomics	10.1002/cfg.110	2001
Metabolism	Reductive precipitation of gold by dissimilatory Fe(III)-reducing bacteria and archaea.	Kashefi K, Tor JM, Nevin KP, Lovley DR.	Appl Environ Microbiol	10.1128/aem.67.7.3275-3279.2001	2001
Enzymology	An unusual oxygen-sensitive, iron- and zinc-containing alcohol dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus.	Ma K, Adams MW.	J Bacteriol	10.1128/jb.181.4.1163-1170.1999	1999
Metabolism	Sulfide dehydrogenase from the hyperthermophilic archaeon Pyrococcus furiosus: a new multifunctional enzyme involved in the reduction of elemental sulfur.	Ma K, Adams MW.	J Bacteriol	10.1128/jb.176.21.6509-6517.1994	1994
	Organic solutes in hyperthermophilic archaea.	Martins LO, Huber R, Huber H, Stetter KO, Da Costa MS, Santos H.	Appl Environ Microbiol	10.1128/aem.63.3.896-902.1997	1997
	Differentiation of regions with atypical oligonucleotide composition in bacterial genomes.	Reva ON, Tummler B.	BMC Bioinformatics	10.1186/1471-2105-6-251	2005
	Bioprocessing data for the production of marine enzymes.	Sarkar S, Pramanik A, Mitra A, Mukherjee J.	Mar Drugs	10.3390/md8041323	2010
	Purification and Characterization of Two Functional Forms of Intracellular Protease PfpI from the Hyperthermophilic Archaeon Pyrococcus furiosus.	Halio SB, Bauer MW, Mukund S, Adams M, Kelly RM.	Appl Environ Microbiol	10.1128/aem.63.1.289-295.1997	1997
Genetics	Hyperbolic rules of the cooperative organization of eukaryotic and prokaryotic genomes.	Petoukhov SV.	Biosystems	10.1016/j.biosystems.2020.104273	2020
Metabolism	The carbamate kinase-like carbamoyl phosphate synthetase of the hyperthermophilic archaeon Pyrococcus furiosus, a missing link in the evolution of carbamoyl phosphate biosynthesis.	Durbecq V, Legrain C, Roovers M, Pierard A, Glansdorff N.	Proc Natl Acad Sci U S A	10.1073/pnas.94.24.12803	1997
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	Displacements of prohead protease genes in the late operons of double-stranded-DNA bacteriophages.	Liu J, Mushegian A.	J Bacteriol	10.1128/jb.186.13.4369-4375.2004	2004
	Growth Physiology of the Hyperthermophilic Archaeon Thermococcus litoralis: Development of a Sulfur-Free Defined Medium, Characterization of an Exopolysaccharide, and Evidence of Biofilm Formation.	Rinker KD, Kelly RM.	Appl Environ Microbiol	10.1128/aem.62.12.4478-4485.1996	1996
Transcriptome	Environment specific substitution tables for thermophilic proteins.	Mizuguchi K, Sele M, Cubellis MV.	BMC Bioinformatics	10.1186/1471-2105-8-s1-s15	2007
Enzymology	Characterization of native and recombinant forms of an unusual cobalt-dependent proline dipeptidase (prolidase) from the hyperthermophilic archaeon Pyrococcus furiosus.	Ghosh M, Grunden AM, Dunn DM, Weiss R, Adams MW.	J Bacteriol	10.1128/jb.180.18.4781-4789.1998	1998
Enzymology	Highly stable L-lysine 6-dehydrogenase from the thermophile Geobacillus stearothermophilus isolated from a Japanese hot spring: characterization, gene cloning and sequencing, and expression.	Heydari M, Ohshima T, Nunoura-Kominato N, Sakuraba H.	Appl Environ Microbiol	10.1128/aem.70.2.937-942.2004	2004
Metabolism	Purification and characterization of two reversible and ADP-dependent acetyl coenzyme A synthetases from the hyperthermophilic archaeon Pyrococcus furiosus.	Mai X, Adams MW.	J Bacteriol	10.1128/jb.178.20.5897-5903.1996	1996
Metabolism	CRISPR-based adaptive immune systems.	Terns MP, Terns RM.	Curr Opin Microbiol	10.1016/j.mib.2011.03.005	2011
Metabolism	Bioenergetics of sulfur reduction in the hyperthermophilic archaeon Pyrococcus furiosus.	Schicho RN, Ma K, Adams MW, Kelly RM.	J Bacteriol	10.1128/jb.175.6.1823-1830.1993	1993
	Alanine aminotransferase variants conferring diverse NUE phenotypes in Arabidopsis thaliana.	McAllister CH, Good AG.	PLoS One	10.1371/journal.pone.0121830	2015
	Regulation of Proteolytic Activity in the Hyperthermophile Pyrococcus furiosus.	Snowden LJ, Blumentals II, Kelly RM.	Appl Environ Microbiol	10.1128/aem.58.4.1134-1141.1992	1992
	Characterization of Amylolytic Enzymes, Having Both alpha-1,4 and alpha-1,6 Hydrolytic Activity, from the Thermophilic Archaea Pyrococcus furiosus and Thermococcus litoralis.	Brown SH, Kelly RM.	Appl Environ Microbiol	10.1128/aem.59.8.2614-2621.1993	1993
	The SopEPhi phage integrates into the ssrA gene of Salmonella enterica serovar Typhimurium A36 and is closely related to the Fels-2 prophage.	Pelludat C, Mirold S, Hardt WD.	J Bacteriol	10.1128/jb.185.17.5182-5191.2003	2003
	Transcriptional regulatory network discovery via multiple method integration: application to e. coli K12.	Sun J, Tuncay K, Haidar AA, Ensman L, Stanley F, Trelinski M, Ortoleva P.	Algorithms Mol Biol	10.1186/1748-7188-2-2	2007
Transcriptome	Complete genome sequence of the chemolithoautotrophic marine magnetotactic coccus strain MC-1.	Schubbe S, Williams TJ, Xie G, Kiss HE, Brettin TS, Martinez D, Ross CA, Schuler D, Cox BL, Nealson KH, Bazylinski DA.	Appl Environ Microbiol	10.1128/aem.02874-08	2009
Enzymology	Purification and molecular characterization of the tungsten-containing formaldehyde ferredoxin oxidoreductase from the hyperthermophilic archaeon Pyrococcus furiosus: the third of a putative five-member tungstoenzyme family.	Roy R, Mukund S, Schut GJ, Dunn DM, Weiss R, Adams MW.	J Bacteriol	10.1128/jb.181.4.1171-1180.1999	1999
Metabolism	An uncharacterized member of the ribokinase family in Thermococcus kodakarensis exhibits myo-inositol kinase activity.	Sato T, Fujihashi M, Miyamoto Y, Kuwata K, Kusaka E, Fujita H, Miki K, Atomi H.	J Biol Chem	10.1074/jbc.m113.457259	2013
Enzymology	Purification and characterization of a thermostable thiol protease from a newly isolated hyperthermophilic Pyrococcus sp.	Morikawa M, Izawa Y, Rashid N, Hoaki T, Imanaka T.	Appl Environ Microbiol	10.1128/aem.60.12.4559-4566.1994	1994
Genetics	Identification of replication origins in archaeal genomes based on the Z-curve method.	Zhang R, Zhang CT.	Archaea	10.1155/2005/509646	2005
Enzymology	Molecular and phylogenetic characterization of pyruvate and 2-ketoisovalerate ferredoxin oxidoreductases from Pyrococcus furiosus and pyruvate ferredoxin oxidoreductase from Thermotoga maritima.	Kletzin A, Adams MW.	J Bacteriol	10.1128/jb.178.1.248-257.1996	1996
Enzymology	Purification and characterization of an alpha-glucosidase from a hyperthermophilic archaebacterium, Pyrococcus furiosus, exhibiting a temperature optimum of 105 to 115 degrees C.	Costantino HR, Brown SH, Kelly RM.	J Bacteriol	10.1128/jb.172.7.3654-3660.1990	1990
Metabolism	A genomic timescale of prokaryote evolution: insights into the origin of methanogenesis, phototrophy, and the colonization of land.	Battistuzzi FU, Feijao A, Hedges SB.	BMC Evol Biol	10.1186/1471-2148-4-44	2004
Metabolism	Modified pathway to synthesize ribulose 1,5-bisphosphate in methanogenic archaea.	Finn MW, Tabita FR.	J Bacteriol	10.1128/jb.186.19.6360-6366.2004	2004
	Characterization of Amylolytic Enzyme Activities Associated with the Hyperthermophilic Archaebacterium Pyrococcus furiosus.	Brown SH, Costantino HR, Kelly RM.	Appl Environ Microbiol	10.1128/aem.56.7.1985-1991.1990	1990
Phylogeny	PAV1, the first virus-like particle isolated from a hyperthermophilic euryarchaeote, "Pyrococcus abyssi".	Geslin C, Le Romancer M, Erauso G, Gaillard M, Perrot G, Prieur D.	J Bacteriol	10.1128/jb.185.13.3888-3894.2003	2003
	Keratin Degradation by Fervidobacterium pennavorans, a Novel Thermophilic Anaerobic Species of the Order Thermotogales.	Friedrich AB, Antranikian G.	Appl Environ Microbiol	10.1128/aem.62.8.2875-2882.1996	1996
	Role of Polysulfides in Reduction of Elemental Sulfur by the Hyperthermophilic Archaebacterium Pyrococcus furiosus.	Blumentals II, Itoh M, Olson GJ, Kelly RM.	Appl Environ Microbiol	10.1128/aem.56.5.1255-1262.1990	1990
Enzymology	Purification, characterization, and application of a novel dye-linked L-proline dehydrogenase from a hyperthermophilic archaeon, Thermococcus profundus.	Sakuraba H, Takamatsu Y, Satomura T, Kawakami R, Ohshima T.	Appl Environ Microbiol	10.1128/aem.67.4.1470-1475.2001	2001
Biotechnology	Discovery and Biotechnological Exploitation of Glycoside-Phosphorylases.	Li A, Benkoulouche M, Ladeveze S, Durand J, Cioci G, Laville E, Potocki-Veronese G.	Int J Mol Sci	10.3390/ijms23063043	2022
	Global prevalence and distribution of genes and microorganisms involved in mercury methylation.	Podar M, Gilmour CC, Brandt CC, Soren A, Brown SD, Crable BR, Palumbo AV, Somenahally AC, Elias DA.	Sci Adv	10.1126/sciadv.1500675	2015
	Minimal Amino Acid Requirements of the Hyperthermophilic Archaeon Pyrococcus abyssi, Isolated from Deep-Sea Hydrothermal Vents.	Watrin L, Martin-Jezequel V, Prieur D.	Appl Environ Microbiol	10.1128/aem.61.3.1138-1140.1995	1995
Enzymology	Modelling the evolution of the archeal tryptophan synthase.	Merkl R.	BMC Evol Biol	10.1186/1471-2148-7-59	2007
	Alignment-free phylogeny of whole genomes using underlying subwords.	Comin M, Verzotto D.	Algorithms Mol Biol	10.1186/1748-7188-7-34	2012
Genetics	The GC skew index: a measure of genomic compositional asymmetry and the degree of replicational selection.	Arakawa K, Tomita M.	Evol Bioinform Online		2007
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Enzymology	Characterization of sodium dodecyl sulfate-resistant proteolytic activity in the hyperthermophilic archaebacterium Pyrococcus furiosus.	Blumentals II, Robinson AS, Kelly RM.	Appl Environ Microbiol	10.1128/aem.56.7.1992-1998.1990	1990
Stress	A novel and remarkably thermostable ferredoxin from the hyperthermophilic archaebacterium Pyrococcus furiosus.	Aono S, Bryant FO, Adams MW.	J Bacteriol	10.1128/jb.171.6.3433-3439.1989	1989
	Reliability and applications of statistical methods based on oligonucleotide frequencies in bacterial and archaeal genomes.	Bohlin J, Skjerve E, Ussery DW.	BMC Genomics	10.1186/1471-2164-9-104	2008
Metabolism	Diversity and transcription of proteases involved in the maturation of hydrogenases in Nostoc punctiforme ATCC 29133 and Nostoc sp. strain PCC 7120.	Devine E, Holmqvist M, Stensjo K, Lindblad P.	BMC Microbiol	10.1186/1471-2180-9-53	2009
Transcriptome	Expression patterns reveal niche diversification in a marine microbial assemblage.	Gifford SM, Sharma S, Booth M, Moran MA.	ISME J	10.1038/ismej.2012.96	2013
Metabolism	A primordial RNA modification enzyme: the case of tRNA (m1A) methyltransferase.	Roovers M, Wouters J, Bujnicki JM, Tricot C, Stalon V, Grosjean H, Droogmans L.	Nucleic Acids Res	10.1093/nar/gkh191	2004
Genetics	Prediction of functional modules based on comparative genome analysis and Gene Ontology application.	Wu H, Su Z, Mao F, Olman V, Xu Y.	Nucleic Acids Res	10.1093/nar/gki573	2005
Enzymology	Reverse gyrase, a hallmark of the hyperthermophilic archaebacteria.	Bouthier de la Tour C, Portemer C, Nadal M, Stetter KO, Forterre P, Duguet M.	J Bacteriol	10.1128/jb.172.12.6803-6808.1990	1990
Enzymology	Identification of individual prokaryotic cells by using enzyme-labeled, rRNA-targeted oligonucleotide probes.	Amann RI, Zarda B, Stahl DA, Schleifer KH.	Appl Environ Microbiol	10.1128/aem.58.9.3007-3011.1992	1992
	The CRISPR-associated gene cas2 of Legionella pneumophila is required for intracellular infection of amoebae.	Gunderson FF, Cianciotto NP.	mBio	10.1128/mbio.00074-13	2013
Metabolism	Maltose metabolism in the hyperthermophilic archaeon Thermococcus litoralis: purification and characterization of key enzymes.	Xavier KB, Peist R, Kossmann M, Boos W, Santos H.	J Bacteriol	10.1128/jb.181.11.3358-3367.1999	1999
Metabolism	Recognition of the 5' leader of pre-tRNA substrates by the active site of ribonuclease P.	Zahler NH, Christian EL, Harris ME.	RNA	10.1261/rna.5220703	2003
Metabolism	A novel pathway for the biosynthesis of heme in Archaea: genome-based bioinformatic predictions and experimental evidence.	Storbeck S, Rolfes S, Raux-Deery E, Warren MJ, Jahn D, Layer G.	Archaea	10.1155/2010/175050	2010
Genetics	Phylogenetic and gene-centric metagenomics of the canine intestinal microbiome reveals similarities with humans and mice.	Swanson KS, Dowd SE, Suchodolski JS, Middelbos IS, Vester BM, Barry KA, Nelson KE, Torralba M, Henrissat B, Coutinho PM, Cann IK, White BA, Fahey GC.	ISME J	10.1038/ismej.2010.162	2011
Genetics	Information theoretic perspective on genome clustering.	Veluchamy A, Mehta P, Srividhya KV, Vikram H, Govind MK, Gupta R, Aziz Bin Dukhyil A, Abdullah Alharbi R, Abdullah Aloyuni S, Hassan MM, Krishnaswamy S.	Saudi J Biol Sci	10.1016/j.sjbs.2020.12.039	2021
	New insight into RNase P RNA structure from comparative analysis of the archaeal RNA.	Harris JK, Haas ES, Williams D, Frank DN, Brown JW.	RNA	10.1017/s1355838201001777	2001
	Structure determination of two new amino acid-containing derivatives of adenosine from tRNA of thermophilic bacteria and archaea.	Reddy DM, Crain PF, Edmonds CG, Gupta R, Hashizume T, Stetter KO, Widdel F, McCloskey JA.	Nucleic Acids Res	10.1093/nar/20.21.5607	1992
Enzymology	ADP-dependent phosphofructokinases in mesophilic and thermophilic methanogenic archaea.	Verhees CH, Tuininga JE, Kengen SW, Stams AJ, van der Oost J, de Vos WM.	J Bacteriol	10.1128/jb.183.24.7145-7153.2001	2001
	Annotation of Protein Domains Reveals Remarkable Conservation in the Functional Make up of Proteomes Across Superkingdoms.	Nasir A, Naeem A, Khan MJ, Nicora HD, Caetano-Anolles G.	Genes (Basel)	10.3390/genes2040869	2011
	Estimating the fraction of non-coding RNAs in mammalian transcriptomes.	Xin Y, Quarta G, Gan HH, Schlick T.	Bioinform Biol Insights	10.4137/bbi.s443	2008
Metabolism	Phylogenomic analysis of proteins that are distinctive of Archaea and its main subgroups and the origin of methanogenesis.	Gao B, Gupta RS.	BMC Genomics	10.1186/1471-2164-8-86	2007
Metabolism	Engineering of cyclodextrin glucanotransferases and the impact for biotechnological applications.	Leemhuis H, Kelly RM, Dijkhuizen L.	Appl Microbiol Biotechnol	10.1007/s00253-009-2221-3	2010
Enzymology	Diversity of the DNA replication system in the Archaea domain.	Sarmiento F, Long F, Cann I, Whitman WB.	Archaea	10.1155/2014/675946	2014
Genetics	Coverage of whole proteome by structural genomics observed through protein homology modeling database.	Yura K, Yamaguchi A, Go M.	J Struct Funct Genomics	10.1007/s10969-006-9010-3	2006
Enzymology	A single nucleotide exchange in the wzy gene is responsible for the semirough O6 lipopolysaccharide phenotype and serum sensitivity of Escherichia coli strain Nissle 1917.	Grozdanov L, Zahringer U, Blum-Oehler G, Brade L, Henne A, Knirel YA, Schombel U, Schulze J, Sonnenborn U, Gottschalk G, Hacker J, Rietschel ET, Dobrindt U.	J Bacteriol	10.1128/jb.184.21.5912-5925.2002	2002
	Distribution, structure and diversity of "bacterial" genes encoding two-component proteins in the Euryarchaeota.	Ashby MK.	Archaea	10.1155/2006/562404	2006
Genetics	Comparative genomics of Archaea: how much have we learned in six years, and what's next?	Makarova KS, Koonin EV.	Genome Biol	10.1186/gb-2003-4-8-115	2003
	A study in entire chromosomes of violations of the intra-strand parity of complementary nucleotides (Chargaff's second parity rule).	Powdel BR, Satapathy SS, Kumar A, Jha PK, Buragohain AK, Borah M, Ray SK.	DNA Res	10.1093/dnares/dsp021	2009
Enzymology	Characterization of a fourth type of 2-keto acid-oxidizing enzyme from a hyperthermophilic archaeon: 2-ketoglutarate ferredoxin oxidoreductase from Thermococcus litoralis.	Mai X, Adams MW.	J Bacteriol	10.1128/jb.178.20.5890-5896.1996	1996
Phylogeny	Comparative genomic analyses of the bacterial phosphotransferase system.	Barabote RD, Saier MH.	Microbiol Mol Biol Rev	10.1128/mmbr.69.4.608-634.2005	2005
	Natural-product sugar biosynthesis and enzymatic glycodiversification.	Thibodeaux CJ, Melancon CE, Liu HW.	Angew Chem Int Ed Engl	10.1002/anie.200801204	2008
	Structural Evidence for DUF512 as a Radical S-Adenosylmethionine Cobalamin-Binding Domain.	Wang B, Solinski AE, Radle MI, Peduzzi OM, Knox HL, Cui J, Maurya RK, Yennawar NH, Booker SJ.	ACS Bio Med Chem Au	10.1021/acsbiomedchemau.4c00067	2024
	Characterization of beta-glucosidase activity of a Lactiplantibacillus plantarum 6-phospho-beta-glucosidase.	Godse R, Fernandes JM, Kulkarni R.	Appl Microbiol Biotechnol	10.1007/s00253-025-13472-8	2025
Metabolism	Pathways of Iron and Sulfur Acquisition, Cofactor Assembly, Destination, and Storage in Diverse Archaeal Methanogens and Alkanotrophs.	Johnson C, England A, Munro-Ehrlich M, Colman DR, DuBois JL, Boyd ES.	J Bacteriol	10.1128/jb.00117-21	2021
Enzymology	Characterization of a Metal-Resistant Bacillus Strain With a High Molybdate Affinity ModA From Contaminated Sediments at the Oak Ridge Reservation.	Ge X, Thorgersen MP, Poole FL, Deutschbauer AM, Chandonia JM, Novichkov PS, Gushgari-Doyle S, Lui LM, Nielsen T, Chakraborty R, Adams PD, Arkin AP, Hazen TC, Adams MWW.	Front Microbiol	10.3389/fmicb.2020.587127	2020
	Quantifying the stabilizing effects of protein-ligand interactions in the gas phase.	Allison TM, Reading E, Liko I, Baldwin AJ, Laganowsky A, Robinson CV.	Nat Commun	10.1038/ncomms9551	2015
Metabolism	Use of a Tn5-based transposon system to create a cost-effective Zymomonas mobilis for ethanol production from lignocelluloses.	Zhang X, Wang T, Zhou W, Jia X, Wang H.	Microb Cell Fact	10.1186/1475-2859-12-41	2013
	Noncellulosomal cohesin- and dockerin-like modules in the three domains of life.	Peer A, Smith SP, Bayer EA, Lamed R, Borovok I.	FEMS Microbiol Lett	10.1111/j.1574-6968.2008.01420.x	2009
Transcriptome	Parallel evolution of transcriptome architecture during genome reorganization.	Yoon SH, Reiss DJ, Bare JC, Tenenbaum D, Pan M, Slagel J, Moritz RL, Lim S, Hackett M, Menon AL, Adams MW, Barnebey A, Yannone SM, Leigh JA, Baliga NS	Genome Res	10.1101/gr.122218.111	2011
	Next Generation DNA-Seq and Differential RNA-Seq Allow Re-annotation of the Pyrococcus furiosus DSM 3638 Genome and Provide Insights Into Archaeal Antisense Transcription.	Grunberger F, Reichelt R, Bunk B, Sproer C, Overmann J, Rachel R, Grohmann D, Hausner W	Front Microbiol	10.3389/fmicb.2019.01603	2019
	Dissecting the Repertoire of DNA-Binding Transcription Factors of the Archaeon Pyrococcus furiosus DSM 3638.	Denis A, Martinez-Nunez MA, Tenorio-Salgado S, Perez-Rueda E	Life (Basel)	10.3390/life8040040	2018
Metabolism	Expression and Characterization of a Novel Glycerophosphodiester Phosphodiesterase from Pyrococcus furiosus DSM 3638 That Possesses Lysophospholipase D Activity.	Wang F, Lai L, Liu Y, Yang B, Wang Y	Int J Mol Sci	10.3390/ijms17060831	2016
Phenotype	A mutant ('lab strain') of the hyperthermophilic archaeon Pyrococcus furiosus, lacking flagella, has unusual growth physiology.	Lewis DL, Notey JS, Chandrayan SK, Loder AJ, Lipscomb GL, Adams MW, Kelly RM	Extremophiles	10.1007/s00792-014-0712-3	2014
	An In Silico Approach for Characterization of an Aminoglycoside Antibiotic-Resistant Methyltransferase Protein from Pyrococcus furiosus (DSM 3638).	Oany AR, Jyoti TP, Ahmad SA	Bioinform Biol Insights	10.4137/BBI.S14620	2014
Metabolism	Crystal structure and nucleic acid-binding activity of the CRISPR-associated protein Csx1 of Pyrococcus furiosus.	Kim YK, Kim YG, Oh BH	Proteins	10.1002/prot.24183	2012
Enzymology	Mutation studies in the active site of beta-glycosidase from Pyrococcus furiosus DSM 3638.	Park S, Alli I, Park K, Oh B, Lee B	Protein Pept Lett	PPL-EPUB-20120712-3	2013
Enzymology	Comparative analysis of the catalytic components in the archaeal dye-linked L-proline dehydrogenase complexes.	Kawakami R, Noguchi C, Higashi M, Sakuraba H, Ohshima T	Appl Microbiol Biotechnol	10.1007/s00253-012-4201-2	2012
Genetics	Re-annotation of two hyperthermophilic archaea Pyrococcus abyssi GE5 and Pyrococcus furiosus DSM 3638.	Gao J, Wang J	Curr Microbiol	10.1007/s00284-011-0035-x	2011
Enzymology	Expression and characterization of an extremely thermostable beta-glycosidase (mannosidase) from the hyperthermophilic archaeon Pyrococcus furiosus DSM3638.	Park SH, Park KH, Oh BC, Alli I, Lee BH	N Biotechnol	10.1016/j.nbt.2011.05.002	2011
Enzymology	Phosphomannose isomerase/GDP-mannose pyrophosphorylase from Pyrococcus furiosus: a thermostable biocatalyst for the synthesis of guanidinediphosphate-activated and mannose-containing sugar nucleotides.	Mizanur RM, Pohl NL	Org Biomol Chem	10.1039/b822794b	2009
Phylogeny	The crystal structure of a virus-like particle from the hyperthermophilic archaeon Pyrococcus furiosus provides insight into the evolution of viruses.	Akita F, Chong KT, Tanaka H, Yamashita E, Miyazaki N, Nakaishi Y, Suzuki M, Namba K, Ono Y, Tsukihara T, Nakagawa A	J Mol Biol	10.1016/j.jmb.2007.02.075	2007
Metabolism	Mechanistic aspects and redox properties of hyperthermophilic L-proline dehydrogenase from Pyrococcus furiosus related to dimethylglycine dehydrogenase/oxidase.	Monaghan PJ, Leys D, Scrutton NS	FEBS J	10.1111/j.1742-4658.2007.05750.x	2007
Enzymology	Characterization of a thermostable cyclodextrin glucanotransferase from Pyrococcus furiosus DSM3638.	Lee MH, Yang SJ, Kim JW, Lee HS, Kim JW, Park KH	Extremophiles	10.1007/s00792-007-0061-6	2007
Enzymology	Crystallization and preliminary X-ray diffraction analysis of a flavoenzyme amine dehydrogenase/oxidase from Pyrococcus furiosus DSM 3638.	Monaghan PJ, Leys D, Scrutton NS	Acta Crystallogr Sect F Struct Biol Cryst Commun	10.1107/S1744309105020737	2005
Enzymology	Unusually broad substrate tolerance of a heat-stable archaeal sugar nucleotidyltransferase for the synthesis of sugar nucleotides.	Mizanur RM, Zea CJ, Pohl NL	J Am Chem Soc	10.1021/ja046070d	2004
Enzymology	Cloning and sequencing of a gene from the archaeon Pyrococcus furiosus with high homology to a gene encoding phosphoenolpyruvate synthetase from Escherichia coli.	Jones CE, Fleming TM, Piper PW, Littlechild JA, Cowan DA	Gene	10.1016/0378-1119(95)00128-s	1995
Phylogeny	Growth requirements of hyperthermophilic sulfur-dependent heterotrophic archaea isolated from a shallow submarine geothermal system with reference to their essential amino acids.	Hoaki T, Nishijima M, Kato M, Adachi K, Mizobuchi S, Hanzawa N, Maruyama T	Appl Environ Microbiol	10.1128/aem.60.8.2898-2904.1994	1994

References

#1428	Leibniz Institut DSMZ-Deutsche Sammlung von Mikroorganismen und Zellkulturen GmbH ; Curators of the DSMZ; DSM 3638
#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#20218	Verslyppe, B., De Smet, W., De Baets, B., De Vos, P., Dawyndt P.: StrainInfo introduces electronic passports for microorganisms.. Syst Appl Microbiol. 37: 42 - 50 2014 ( DOI 10.1016/j.syapm.2013.11.002 , PubMed 24321274 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#66794	Antje Chang, Lisa Jeske, Sandra Ulbrich, Julia Hofmann, Julia Koblitz, Ida Schomburg, Meina Neumann-Schaal, Dieter Jahn, Dietmar Schomburg: BRENDA, the ELIXIR core data resource in 2021: new developments and updates. Nucleic Acids Res. 49: D498 - D508 2020 ( DOI 10.1093/nar/gkaa1025 , PubMed 33211880 )
#67770	Japan Collection of Microorganism (JCM) ; Curators of the JCM;
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Pyrococcus furiosus (DSM 3638, ATCC 43587, JCM 8422)

Name and taxonomic classification

Morphology

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