Brachyspira pilosicoli (ATCC 51139, P43/6/78)

Name: Brachyspira pilosicoli (ATCC 51139, P43/6/78)
Creator: BacDive
License: http://creativecommons.org/licenses/by/4.0/

BacDive ID 167613

Type strain

Strain Designation P43/6/78

Culture col. no. ATCC 51139 P43/6/78

NCBI tax ID(s) 1042417 52584

Links

Brachyspira pilosicoli P43/6/78 is a human pathogen of the family Brachyspiraceae.

human pathogen genome sequence 16S sequence Bacteria

Name and taxonomic classification

SI-ID 42824

ATCC 51139

@ref 20215

Last LPSN update 2026-02-09 11:40:37

Domain Bacteria

Phylum Spirochaetota

Class Spirochaetia

Order Brachyspirales

Family Brachyspiraceae

Genus Brachyspira

Species Brachyspira pilosicoli

Full scientific name Brachyspira pilosicoli (Trott et al. 1996) Ochiai et al. 1998

Synonyms (1)

Serpulina pilosicoli

BacDive ID	Other strains from **Brachyspira pilosicoli** (1)	Type strain
159519	B. pilosicoli 1926, 2492/17, DSM 110984

Morphology

Cell morphology

@ref	Gram stain	Confidence
125439	negative	99.2

Culture and growth conditions

Physiology and metabolism

Spore formation

@ref	Spore formation	Confidence
125439		93.7

Isolation, sampling and environmental information

Taxonmaps

69479

Global distribution of 16S sequence U14927 (>99% sequence identity) for Brachyspira pilosicoli subclade from Microbeatlas

Aquatic Samples	167
Soil Samples	43
Animal Samples	8828
Plant Samples	59
Total Samples	9097

Interaction and safety

Risk assessment

@ref	Pathogenicity human	Pathogenicity animal	Biosafety level	Biosafety level comment
20215			2	Risk group

Sequence information

Genome sequences

@ref	Description	Assembly level	INSDC accession	BV-BRC accession	IMG accession	NCBI tax ID	Score
66792	ASM32566v1 assembly for Brachyspira pilosicoli P43/6/78	complete	GCA_000325665	1042417.4	2521172718	1042417	95.65

16S sequences

@ref	Description	Accession	Length	Database	NCBI tax ID
20215	Brachyspira pilosicoli strain P43/6/78 16S ribosomal RNA (rrn) gene, partial sequence	U14927	1431		1042417
124043	Brachyspira pilosicoli 16S ribosomal RNA gene, partial sequence.	AY155458	1462		1042417

Genome-based predictions

Predictions

Predictions from Deep Learning for Genome Sequence Data. R package version 0.3.1 based on: Brachyspira pilosicoli P43/6/78
NCBI: GCA_000325665

@ref	Trait	Model	Prediction	Confidence in %	In training data
125439	oxygen_tolerance	BacteriaNetⓘ	obligate aerobe	87.90	no
125439	gram_stain	BacteriaNetⓘ	negative	99.20	no
125439	motility	BacteriaNetⓘ	no	55.60	no
125439	spore_formation	BacteriaNetⓘ	no	93.70	no

Predictions from bacterial phenotypic traits through improved machine learning using high-quality, curated datasets based on: Brachyspira pilosicoli P43/6/78 P43/6/78
NCBI: GCA_000325665.1

@ref	Trait	Model	Prediction	Confidence in %	In training data
125438	gram-positive	gram-positiveⓘ	no	89.72	no
125438	anaerobic	anaerobicⓘ	yes	79.00	no
125438	aerobic	aerobicⓘ	no	89.31	no
125438	spore-forming	spore-formingⓘ	no	87.43	no
125438	thermophilic	thermophileⓘ	no	84.26	no
125438	flagellated	motile2+ⓘ	no	50.50	no

Literature

Topic	Title	Authors	Journal	DOI	Year
	BPP43_05035 is a Brachyspira pilosicoli cell surface adhesin that weakens the integrity of the epithelial barrier during infection.	Rajan A, Gallego P, Dolan B, Patel P, Dwibedi C, Luis AS, Trillo-Muyo S, Arike L, van der Post S, Simren M, Pelaseyed T.	Gut Microbes	10.1080/19490976.2024.2409247	2024
	Brachyspira hyodysenteriae and B. pilosicoli Proteins Recognized by Sera of Challenged Pigs.	Casas V, Rodriguez-Asiain A, Pinto-Llorente R, Vadillo S, Carrascal M, Abian J.	Front Microbiol	10.3389/fmicb.2017.00723	2017
	Development of a multiplex quantitative PCR assay for simultaneous detection of Treponema phagedenis, Treponema pedis, Treponema medium, and 'Treponema vincentii' and evaluation on bovine digital dermatitis biopsies.	Frosth S, Eriksson HK, Rosander A.	Vet Res Commun	10.1007/s11259-023-10147-5	2023
	Antimicrobial susceptibility of western Canadian Brachyspira isolates: Development and standardization of an agar dilution susceptibility test method.	Kulathunga DGRS, Harding JCS, Rubin JE.	PLoS One	10.1371/journal.pone.0286594	2023
Phylogeny	Development of a real-time PCR for identification of brachyspira species in human colonic biopsies.	Westerman LJ, Stel HV, Schipper ME, Bakker LJ, Neefjes-Borst EA, van den Brande JH, Boel EC, Seldenrijk KA, Siersema PD, Bonten MJ, Kusters JG.	PLoS One	10.1371/journal.pone.0052281	2012
Enzymology	Brachyspira pilosicoli bloodstream infections: case report and review of the literature.	Bait-Merabet L, Thille A, Legrand P, Brun-Buisson C, Cattoir V.	Ann Clin Microbiol Antimicrob	10.1186/1476-0711-7-19	2008
Metabolism	Penicillin-binding proteins in the pathogenic intestinal spirochete Brachyspira pilosicoli.	Dassanayake RP, Sarath G, Duhamel GE.	Antimicrob Agents Chemother	10.1128/aac.49.4.1561-1563.2005	2005
Pathogenicity	Antimicrobial Susceptibility Patterns of Brachyspira Species Isolated from Swine Herds in the United States.	Mirajkar NS, Davies PR, Gebhart CJ.	J Clin Microbiol	10.1128/jcm.00834-16	2016
	Actinobaculum suis detection using polymerase chain reaction.	Amigo CR, Sena de Gobbi DD, Gomes VT, Perina Ddo P, Nogueira de Lima Filsner PH, Costa BL, Spindola MG, Ferreira TS, Brandao PE, Moreno AM.	ScientificWorldJournal	10.1100/2012/572732	2012
	The Exposed Proteomes of Brachyspira hyodysenteriae and B. pilosicoli.	Casas V, Vadillo S, San Juan C, Carrascal M, Abian J.	Front Microbiol	10.3389/fmicb.2016.01103	2016
Phylogeny	Identification of Brachyspira hyodysenteriae and other pathogenic Brachyspira species in chickens from laying flocks with diarrhea or reduced production or both.	Feberwee A, Hampson DJ, Phillips ND, La T, van der Heijden HM, Wellenberg GJ, Dwars RM, Landman WJ.	J Clin Microbiol	10.1128/jcm.01829-07	2008
Phylogeny	Diagnostic examination of human intestinal spirochetosis by fluorescent in situ hybridization for Brachyspira aalborgi, Brachyspira pilosicoli, and other species of the genus Brachyspira (Serpulina).	Jensen TK, Boye M, Ahrens P, Korsager B, Teglbjaerg PS, Lindboe CF, Moller K.	J Clin Microbiol	10.1128/jcm.39.11.4111-4118.2001	2001
	Cloning and DNA sequence analysis of an immunogenic glucose-galactose MglB lipoprotein homologue from Brachyspira pilosicoli, the agent of colonic spirochetosis.	Zhang P, Cheng X, Duhamel GE.	Infect Immun	10.1128/iai.68.8.4559-4565.2000	2000
Enzymology	Ileocolitis associated with Anaerobiospirillum in cats.	De Cock HE, Marks SL, Stacy BA, Zabka TS, Burkitt J, Lu G, Steffen DJ, Duhamel GE.	J Clin Microbiol	10.1128/jcm.42.6.2752-2758.2004	2004
Genetics	Complete Genome Sequence of the Porcine Strain Brachyspira pilosicoli P43/6/78(T.).	Lin C, den Bakker HC, Suzuki H, Lefebure T, Ponnala L, Sun Q, Stanhope MJ, Wiedmann M, Duhamel GE	Genome Announc	10.1128/genomeA.00215-12	2013
	Genetic variation in Brachyspira: chromosomal rearrangements and sequence drift distinguish B. pilosicoli from B. hyodysenteriae.	Zuerner RL, Stanton TB, Minion FC, Li C, Charon NW, Trott DJ, Hampson DJ	Anaerobe	10.1016/j.anaerobe.2004.05.002	2004
Metabolism	Neither hippurate-negative Brachyspira pilosicoli nor Brachyspira pilosicoli type strain caused diarrhoea in early-weaned pigs by experimental infection.	Fossil M, Ahlsten K, Pohjanvirta T, Anttila M, Kokkonen T, Jensen TK, Boye M, Sukura A, Pelkola K, Pelkonen S	Acta Vet Scand	10.1186/1751-0147-46-257	2005
Enzymology	Molecular and ultrastructural characterization of porcine hippurate-negative Brachyspira pilosicoli.	Fossi M, Pohjanvirta T, Sukura A, Heinikainen S, Lindecrona R, Pelkonen S	J Clin Microbiol	10.1128/JCM.42.7.3153-3158.2004	2004
Phylogeny	Detection of same sized 4.3 Kb extrachromosomal DNA elements in weakly beta-haemolytic human intestinal spirochaetes and Serpulina pilosicoli of swine origin.	Calderaro A, Cattani P, Dettori G, Ragni P, Grillo R, Guegan R, Fadda G, Chezzi C	New Microbiol		2000
Pathogenicity	Motility-regulated mucin association of Serpulina pilosicoli, the agent of colonic spirochetosis of humans and animals.	Witters NA, Duhamel GE	Adv Exp Med Biol	10.1007/978-1-4615-4143-1_20	1999
Pathogenicity	Bacteriophages induced from weakly beta-haemolytic human intestinal spirochaetes by mitomycin C.	Calderaro A, Dettori G, Collini L, Ragni P, Grillo R, Cattani P, Fadda G, Chezzi C	J Basic Microbiol	10.1002/(SICI)1521-4028(199811)38:5/6<323::AID-JOBM323>3.0.CO;2-6	1998
Pathogenicity	Search for bacteriophages spontaneously occurring in cultures of haemolytic intestinal spirochaetes of human and animal origin.	Calderaro A, Dettori G, Grillo R, Plaisant P, Amalfitano G, Chezzi C	J Basic Microbiol	10.1002/(SICI)1521-4028(199811)38:5/6<313::AID-JOBM313>3.0.CO;2-A	1998
Enzymology	In vitro activity of four antimicrobial agents against North American isolates of porcine Serpulina pilosicoli.	Duhamel GE, Kinyon JM, Mathiesen MR, Murphy DP, Walter D	J Vet Diagn Invest	10.1177/104063879801000407	1998
Enzymology	Identification of a gene sequence encoding a putative pyruvate oxidoreductase in Serpulina pilosicoli.	Rayment SJ, Lee BJ, Hampson DJ, Livesley MA	FEMS Microbiol Lett	10.1111/j.1574-6968.1998.tb13192.x	1998
Pathogenicity	Phenotypic characteristics of Serpulina pilosicoli the agent of intestinal spirochaetosis.	Trott DJ, Stanton TB, Jensen NS, Hampson DJ	FEMS Microbiol Lett	10.1111/j.1574-6968.1996.tb08432.x	1996
Phylogeny	Recognition of two new species of intestinal spirochetes: Serpulina intermedia sp. nov. and Serpulina murdochii sp. nov.	Stanton TB, Fournie-Amazouz E, Postic D, Trott DJ, Grimont PA, Baranton G, Hampson DJ, Saint Girons I	Int J Syst Bacteriol	10.1099/00207713-47-4-1007	1997
Phylogeny	Serpulina pilosicoli sp. nov., the agent of porcine intestinal spirochetosis.	Trott DJ, Stanton TB, Jensen NS, Duhamel GE, Johnson JL, Hampson DJ	Int J Syst Bacteriol	10.1099/00207713-46-1-206	1996

References

#20215	Parte, A.C., Sardà Carbasse, J., Meier-Kolthoff, J.P., Reimer, L.C. and Göker, M.: List of Prokaryotic names with Standing in Nomenclature (LPSN) moves to the DSMZ. IJSEM ( DOI 10.1099/ijsem.0.004332 )
#66792	Julia Koblitz, Joaquim Sardà, Lorenz Christian Reimer, Boyke Bunk, Jörg Overmann: Automatically annotated for the DiASPora project (Digital Approaches for the Synthesis of Poorly Accessible Biodiversity Information) .
#69479	João F Matias Rodrigues, Janko Tackmann,Gregor Rot, Thomas SB Schmidt, Lukas Malfertheiner, Mihai Danaila,Marija Dmitrijeva, Daniela Gaio, Nicolas Näpflin and Christian von Mering. University of Zurich.: MicrobeAtlas 1.0 beta .
#124043	Isabel Schober, Julia Koblitz: Data extracted from sequence databases, automatically matched based on designation and taxonomy .
#125438	Julia Koblitz, Lorenz Christian Reimer, Rüdiger Pukall, Jörg Overmann: Predicting bacterial phenotypic traits through improved machine learning using high-quality, curated datasets. 2024 ( DOI 10.1101/2024.08.12.607695 )
#125439	Philipp Münch, René Mreches, Martin Binder, Hüseyin Anil Gündüz, Xiao-Yin To, Alice McHardy: deepG: Deep Learning for Genome Sequence Data. R package version 0.3.1 .
#126262	A. Lissin, I. Schober, J. F. Witte, H. Lüken, A. Podstawka, J. Koblitz, B. Bunk, P. Dawyndt, P. Vandamme, P. de Vos, J. Overmann, L. C. Reimer: StrainInfo—the central database for linked microbial strain identifiers. ( DOI 10.1093/database/baaf059 )

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Brachyspira pilosicoli (ATCC 51139, P43/6/78)

Name and taxonomic classification

Morphology

Cell morphology

Culture and growth conditions

Physiology and metabolism

Spore formation

Isolation, sampling and environmental information

Taxonmaps

Interaction and safety

Risk assessment

Sequence information

Genome sequences

Genome browser: GCA_000325665

16S sequences

Genome-based predictions

Predictions

Literature

Literature

References

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